CN115429806A - 具有降低的心血管作用的避孕组合物 - Google Patents
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- CN115429806A CN115429806A CN202211257175.1A CN202211257175A CN115429806A CN 115429806 A CN115429806 A CN 115429806A CN 202211257175 A CN202211257175 A CN 202211257175A CN 115429806 A CN115429806 A CN 115429806A
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- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
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| PCT/EP2019/052980 WO2019154899A1 (en) | 2018-02-07 | 2019-02-07 | Contraceptive composition with reduced cardiovascular effects |
| CN201980012248.0A CN111683664A (zh) | 2018-02-07 | 2019-02-07 | 具有降低的心血管作用的避孕组合物 |
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| DK3701944T3 (da) | 2015-06-18 | 2022-03-14 | Estetra Srl | Oro-dispergerbar doseringsenhed indeholdende en estetrolkomponent |
| LT3310346T (lt) | 2015-06-18 | 2021-06-10 | Estetra Sprl | Burnoje disperguojama tabletė, turinti estetrolio |
| LT3310345T (lt) | 2015-06-18 | 2021-06-25 | Estetra Sprl | Burnoje disperguojama tabletė, turinti estetrolio |
| CR20180042A (es) | 2015-06-18 | 2018-05-03 | Mithra Pharmaceuticals S A | Unidad de dosificación orodispersable que contiene un componente estetrol. |
| KR102712911B1 (ko) | 2016-08-05 | 2024-10-04 | 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 | 월경통 및 생리통의 관리방법 |
| CN111989105B (zh) | 2018-04-19 | 2024-07-19 | 埃斯特拉私人有限责任公司 | 化合物以及它们在缓解绝经相关症状中的用途 |
| TWI801561B (zh) | 2018-04-19 | 2023-05-11 | 比利時商依思特拉私人有限責任公司 | 化合物及其用於緩解絕經相關症狀的用途 |
| HU231240B1 (hu) | 2019-09-03 | 2022-04-28 | Richter Gedeon Nyrt. | Ipari eljárás nagytisztaságú ösztetrol hatóanyag előállítására |
| TWI893101B (zh) * | 2020-04-16 | 2025-08-11 | 比利時商埃斯特拉有限責任公司 | 具有降低之副作用之避孕組成物 |
| WO2022248733A1 (en) | 2021-05-28 | 2022-12-01 | Neuralis Sa | Use of estetrol in treatment of respiratory infection diseases |
Citations (1)
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| WO2002094279A1 (en) * | 2001-05-23 | 2002-11-28 | Pantarhei Bioscience B.V. | Drug delivery system comprising a tetrahidroxilated estrogen for use in hormonal contraception |
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| DE4344405C2 (de) | 1993-12-24 | 1995-12-07 | Marika Dr Med Ehrlich | Ovulationshemmendes Mittel und Verfahren zur hormonalen Kontrazeption |
| EP1535618A1 (en) * | 2003-11-26 | 2005-06-01 | Schering Aktiengesellschaft | Pharmaceutical preparation for continuous hormonal treatment over a period of longer than 21-28 days comprising two estrogen and/or progestin compositions |
| CA2762640A1 (en) * | 2009-05-22 | 2010-11-25 | Stefanie Lindemann | Medication for oral administration, comprising at least one estrogen and/or at least one gestagen and at least one probiotic bacterial strain |
| WO2012055840A1 (en) * | 2010-10-28 | 2012-05-03 | Bayer Pharma Aktiengesellschaft | Composition and preparation for treatment of dysmenorrhea and menstrual pain and use of a hormonal agent and a zinc salt for treatment of menstrual disorders |
| JP6447931B2 (ja) * | 2013-12-12 | 2019-01-09 | ドネスタ バイオサイエンス ビー．ブイ．Ｄｏｎｅｓｔａ Ｂｉｏｓｃｉｅｎｃｅ Ｂ．Ｖ． | エステトロール成分を含有する口腔内崩壊固体単位剤形 |
| CA3041016C (en) | 2016-10-28 | 2023-09-05 | Estetra Sprl | Method for the management of dysmenorrhea and menstrual pain |
| KR102712911B1 (ko) * | 2016-08-05 | 2024-10-04 | 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 | 월경통 및 생리통의 관리방법 |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002094279A1 (en) * | 2001-05-23 | 2002-11-28 | Pantarhei Bioscience B.V. | Drug delivery system comprising a tetrahidroxilated estrogen for use in hormonal contraception |
Non-Patent Citations (3)
| Title |
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| CORNELIS KLUFT ET AL.: "Reduced hemostatic effects with drospirenone-based oral contraceptives containing estetrol vs. ethinyl estradiol", 《CONTRACEPTION》, vol. 95, pages 141 * |
| WESTHOFF C L, EISENBERGER A, TANG R, ET AL: "Clotting factor changes during the first cycle of oral contraceptive use", 《 CONTRACEPTION》, vol. 93, 31 January 2016 (2016-01-31) * |
| 邵敬於;杨帆;杨健之;李昆明;: "人类诱发排卵的50年进展", 世界临床药物, no. 12 * |
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| JP2024009834A (ja) | 2024-01-23 |
| CN111683664A (zh) | 2020-09-18 |
| JOP20200169A1 (ar) | 2020-07-07 |
| IL276584B2 (en) | 2024-10-01 |
| CA3178181A1 (en) | 2019-08-15 |
| IL276584B1 (en) | 2024-06-01 |
| EP3749327A1 (en) | 2020-12-16 |
| AU2019219070B2 (en) | 2024-12-19 |
| TW202011967A (zh) | 2020-04-01 |
| SG11202007163WA (en) | 2020-08-28 |
| GEAP202215414A (en) | 2022-04-25 |
| ECSP20054822A (es) | 2020-12-31 |
| AU2019219070A1 (en) | 2020-09-24 |
| IL276584A (en) | 2020-09-30 |
| JP7651645B2 (ja) | 2025-03-26 |
| NZ766027A (en) | 2026-03-27 |
| GEP20227407B (en) | 2022-08-25 |
| PH12020500601A1 (en) | 2021-05-17 |
| WO2019154899A1 (en) | 2019-08-15 |
| KR20200118464A (ko) | 2020-10-15 |
| CA3089804A1 (en) | 2019-08-15 |
| UY38075A (es) | 2019-10-01 |
| MA51733A (fr) | 2020-12-16 |
| CL2020002017A1 (es) | 2020-12-04 |
| EP4140489A1 (en) | 2023-03-01 |
| PY1908892A (es) | 2019-10-15 |
| TWI845496B (zh) | 2024-06-21 |
| JP2021513507A (ja) | 2021-05-27 |
| UA126746C2 (uk) | 2023-01-18 |
| KR102717921B1 (ko) | 2024-10-16 |
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