CN115427456A - 基于喹唑啉的酪氨酸激酶抑制剂在具有nrg1融合的癌症的治疗中的用途 - Google Patents

基于喹唑啉的酪氨酸激酶抑制剂在具有nrg1融合的癌症的治疗中的用途 Download PDF

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CN115427456A
CN115427456A CN202180026290.5A CN202180026290A CN115427456A CN 115427456 A CN115427456 A CN 115427456A CN 202180026290 A CN202180026290 A CN 202180026290A CN 115427456 A CN115427456 A CN 115427456A
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cancer
nrg1
fusion
iacs
patient
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J·海马赫
J·罗比肖
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University of Texas System
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University of Texas System
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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CN202180026290.5A 2020-01-29 2021-01-29 基于喹唑啉的酪氨酸激酶抑制剂在具有nrg1融合的癌症的治疗中的用途 Pending CN115427456A (zh)

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US202062967282P 2020-01-29 2020-01-29
US62/967,282 2020-01-29
PCT/US2021/015704 WO2021155144A1 (en) 2020-01-29 2021-01-29 Use of quinazoline-based tyrosine kinase inhibitors for the treatment of cancers with nrg1 fusions

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CN115427456A true CN115427456A (zh) 2022-12-02

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US (1) US20230121116A1 (https=)
EP (1) EP4097140A4 (https=)
JP (1) JP7734139B2 (https=)
KR (1) KR20220133927A (https=)
CN (1) CN115427456A (https=)
CA (1) CA3166298A1 (https=)
WO (1) WO2021155144A1 (https=)

Families Citing this family (2)

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JP2024523001A (ja) * 2021-06-03 2024-06-25 メルス ナムローゼ フェンノートシャップ 新たなｎｒｇ１融合体、融合接合部及びそれらを検出するための方法
WO2022266426A1 (en) * 2021-06-17 2022-12-22 Black Diamond Therapeutics, Inc. 6-(heterocycloalkyl-oxy)-quinazoline derivatives and uses thereof

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WO2019051155A1 (en) * 2017-09-08 2019-03-14 The Regents Of The University Of Colorado, A Body Corporate COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING HER INDUCED PHARMACORE-RESISTANT CANCERS
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WO2009042618A1 (en) * 2007-09-24 2009-04-02 Tragara Pharmaceuticals, Inc. Therapies for treating cancer using combinations of cox-2 inhibitors and anti-her2(erbb2) antibodies or combinations of cox-2 inhibitors and her2(erbb2) receptor tyrosine kinase inhibitors
WO2016201454A1 (en) * 2015-06-12 2016-12-15 The Translational Genomics Research Institute Targeted therapies for cancer
WO2019051155A1 (en) * 2017-09-08 2019-03-14 The Regents Of The University Of Colorado, A Body Corporate COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING HER INDUCED PHARMACORE-RESISTANT CANCERS
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CA3166298A1 (en) 2021-08-05
JP2023513013A (ja) 2023-03-30
WO2021155144A1 (en) 2021-08-05
KR20220133927A (ko) 2022-10-05
JP7734139B2 (ja) 2025-09-04
EP4097140A1 (en) 2022-12-07
US20230121116A1 (en) 2023-04-20

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