CN115427080A - 靶向蛋白酶降解(ted)平台 - Google Patents

靶向蛋白酶降解(ted)平台 Download PDF

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CN115427080A
CN115427080A CN202180027462.0A CN202180027462A CN115427080A CN 115427080 A CN115427080 A CN 115427080A CN 202180027462 A CN202180027462 A CN 202180027462A CN 115427080 A CN115427080 A CN 115427080A
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ubi
mmol
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reaction
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曹小冬
王晓磊
黄超然
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Jiaxing Youbo Biotechnology Co ltd
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Abstract

一种靶向蛋白酶降解(TED)平台，具体地，涉及一种式I所示的靶标分子‑连接体‑E3连接酶配体的偶联物，RT‑L1‑RE3(式I)，其中，所述RT为靶标分子的一价基团；所述RE3为E3连接酶配体的一价基团；所述L1为连接A和B的连接头；且L1如下式II所示：‑W‑L2‑W2‑(II)。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN202180027462.0A 2020-04-09 2021-04-09 靶向蛋白酶降解(ted)平台 Pending CN115427080A (zh)

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CN2020102763012 2020-04-09
CN202010276301.2A CN113509557A (zh) 2020-04-09 2020-04-09 靶向蛋白酶降解平台(ted)
PCT/IB2021/052954 WO2021205391A1 (zh) 2020-04-09 2021-04-09 靶向蛋白酶降解(ted)平台

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JP2023520940A (ja) 2023-05-22
CN113509557A (zh) 2021-10-19
AU2021253833A1 (en) 2022-12-08
WO2021205391A1 (zh) 2021-10-14
CA3179967A1 (en) 2021-10-14

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