CN115400178A - Anti-allergic traditional Chinese medicine composition and preparation method and application thereof - Google Patents
Anti-allergic traditional Chinese medicine composition and preparation method and application thereof Download PDFInfo
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- CN115400178A CN115400178A CN202211274418.2A CN202211274418A CN115400178A CN 115400178 A CN115400178 A CN 115400178A CN 202211274418 A CN202211274418 A CN 202211274418A CN 115400178 A CN115400178 A CN 115400178A
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Classifications
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and particularly discloses an anti-allergic traditional Chinese medicine composition, and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 40 to 50 parts of belvedere fruit, 30 to 50 parts of codonopsis pilosula, 25 to 40 parts of divaricate saposhnikovia root, 20 to 35 parts of radix rehmanniae recen, 20 to 30 parts of cassia twig, 20 to 30 parts of tuckahoe, 15 to 25 parts of white paeony root, 10 to 20 parts of Chinese date and 8 to 15 parts of liquorice. The traditional Chinese medicine composition provided by the invention has a better relieving effect on allergic dermatitis, the raw materials used are low in toxic and side effects, and no adverse reaction occurs during use.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly discloses an anti-allergic traditional Chinese medicine composition, and a preparation method and application thereof.
Background
Allergic diseases can occur in all age stages from newborns to the elderly, often with a marked genetic predisposition. Among allergic diseases, immediate type anaphylaxis is common, and the main types include skin anaphylaxis, respiratory anaphylaxis, digestive tract anaphylaxis, anaphylactic shock and the like, and the common diseases include the following: allergic dermatitis, allergic asthma, allergic rhinitis, allergic purpura, anaphylactic shock, etc. Allergic reactions are characterized by rapid onset, strong reaction, and rapid regression; generally, the method does not damage tissue cells, does not cause serious damage to tissues, and has obvious genetic tendency and individual difference.
Allergic dermatitis is a common and multiple disease in dermatology, the main disease parts are forehead, eyelid, cheeks, cheek and the like of the face, and sometimes skin diseases also occur on ears and scalp. Allergic dermatitis is further classified into: (1) drug eruption: some drugs cause skin allergic reactions, mainly manifested as erythema, purpura, blisters, cuticle laxity, itching and pain, sometimes accompanied by low fever; (2) contact dermatitis: the skin is contacted with substances such as jewelry, cosmetics and the like, so that erythema, edema, itching and pain are generated on the local part, and the serious skin can be soaked in water and peeled off; (3) eczema: erythema, pimple, blister, erosion, exudation, incrustation, desquamation, pigmentation, severe pruritus and obvious exudation can be seen locally or systemically; (4) urticaria: sudden severe itching or burning sensation of the skin, rapidly appearing local massive and localized swelling wind mass, small to rice grains and large to palms, usually nails to coins, slightly higher than the surrounding skin; (5) food allergy: foods such as milk, flour, corns, eggs, sugar, tomatoes, fruits, partial meat and the like can cause allergy, the food allergy can be various, rash is most common, erythema on the face and around the mouth frequently occurs, body parts are more common, pruritus and desquamation occur, pigmentation can occur, nausea, diarrhea and abdominal pain also occur; (6) environmental factors cause allergies: pollen, mold, dust, tree, tobacco, smoke, perfume, gasoline, paint, insecticide, pet, etc. may cause allergy, etc.
The western medicine mostly adopts antihistamine drugs or corticosteroid hormones, such as chlorpheniramine and loratadine, but the drugs have the side effects of dizziness, somnolence, hypodynamia, central obesity and the like, and are easy to cause repeated attack and can not completely eradicate the allergic dermatitis.
Therefore, it is necessary to provide an antiallergic agent having low toxic and side effects and excellent therapeutic effects.
Disclosure of Invention
In view of the above technical problems, the present invention provides the following technical solutions:
the invention provides an anti-allergic traditional Chinese medicine composition which is prepared from the following raw materials in parts by weight: 40 to 50 parts of belvedere fruit, 30 to 50 parts of codonopsis pilosula, 25 to 40 parts of divaricate saposhnikovia root, 20 to 35 parts of radix rehmanniae recen, 20 to 30 parts of cassia twig, 20 to 30 parts of tuckahoe, 15 to 25 parts of white paeony root, 10 to 20 parts of Chinese date and 8 to 15 parts of liquorice.
Preferably, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 40 to 45 portions of belvedere fruit, 30 to 40 portions of radix codonopsitis, 30 to 40 portions of divaricate saposhnikovia root, 25 to 35 portions of radix rehmanniae recen, 20 to 25 portions of cassia twig, 20 to 25 portions of tuckahoe, 18 to 25 portions of white paeony root, 12 to 15 portions of Chinese date and 8 to 12 portions of liquorice.
Preferably, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 45 parts of fructus kochiae, 38 parts of codonopsis pilosula, 35 parts of divaricate saposhnikovia root, 32 parts of radix rehmanniae recen, 25 parts of cassia twig, 25 parts of poria cocos, 20 parts of white paeony root, 15 parts of Chinese date and 10 parts of liquorice.
In a second aspect of the present invention, a preparation method of the traditional Chinese medicine composition is provided, which comprises the following steps:
weighing belvedere fruit, codonopsis pilosula, divaricate saposhnikovia root, radix rehmanniae, cassia twig, poria cocos, white paeony root, chinese date and liquorice for later use;
mixing the weighed traditional Chinese medicine raw materials, adding water for decoction, and filtering decoction to obtain the traditional Chinese medicine composition.
Preferably, the specific operation process of decocting with water is as follows: adding water which is 6-10 times of the total weight of the mixture of the traditional Chinese medicine raw materials, decocting for 2-3 times, 1.0-2.0 h each time, combining the decoction, and filtering to obtain the traditional Chinese medicine composition.
Preferably, the traditional Chinese medicine composition can be further prepared into a pharmaceutically acceptable traditional Chinese medicine preparation.
Preferably, the traditional Chinese medicine preparation is an oral preparation or an external preparation.
Preferably, the oral preparation is granules, capsules, oral liquid or tablets, and the external preparation is paste, spray, patch, lotion, plastics or gel.
In a third aspect of the invention, an antiallergic traditional Chinese medicine gel is provided, which is prepared according to the following steps:
concentrating the traditional Chinese medicine composition prepared by the method until the relative density is 1.05-1.10, adding auxiliary materials, and uniformly mixing to obtain traditional Chinese medicine gel;
the traditional Chinese medicine gel is prepared from the following raw materials in parts by mass: 20 to 28 percent of concentrate of the traditional Chinese medicine composition, 0.8 to 2.5 percent of matrix, 0.5 to 2.0 percent of film forming agent, 3 to 8 percent of humectant, 0.8 to 2.5 percent of penetration enhancer, 0.01 to 0.12 percent of preservative and the balance of water.
In a fourth aspect of the invention, the invention provides an application of the traditional Chinese medicine composition in preparing a medicine for treating allergic dermatitis.
The traditional Chinese medicine holds that the allergy is mainly caused by the dysfunction of the lung, the spleen and the kidney. The lung governs respiration, and the lung is not cold or hot, so the lung is easily attacked by exogenous wind-cold pathogens to cause discomfort of the skin. The spleen governs transportation and transformation, and malnutrition also damages the spleen and stomach, so that the poor metabolism of transportation and transformation tends to cause wind, cold and dampness, the cold and dampness is the internal retention of yin pathogen, the yang is marked on the exterior or the upper surface, and the wind pathogen attacks the exterior, thus causing skin allergic diseases. Kidneys regulate qi and blood, and regulate water metabolism. If kidney yang is insufficient, qi and qi are not enough, and water evaporation is also imbalance, so as to cause dryness of skin, and at the same time, cold-dampness is likely to be endogenous to transform into damp-heat, so that the body is affected by wind, cold, damp and heat. According to the attribute of skin allergic diseases, the traditional Chinese medicine divides the skin allergic diseases into three syndrome types: 1. exogenous pathogenic wind, cold and heat with type of clamp; 2. cold-dampness accumulation in the interior, wind-induced disharmony; 3. spleen deficiency with damp-heat and wind-heat disturbing upward type.
The traditional Chinese medicine composition provided by the invention takes the belvedere fruit and the codonopsis pilosula as monarch medicines, has the effects of dispelling wind and eliminating dampness, strengthening spleen and replenishing qi, has the cold property of the belvedere fruit, clearing internal heat, drawing firewood from a kettle bottom, radically eliminating damp heat, strengthening spleen and replenishing qi, strengthening body resistance and eliminating evil, and prevents damp evil from invading the body again. The divaricate saposhnikovia root helps the monarch drug to expel wind and remove dampness, and the dried rehmannia root is used for nourishing yin, promoting the production of body fluid, clearing heat and cooling blood; the cassia twig regulates ying and wei, and sweats when ying and wei are normally opened, so as to achieve the effect of eliminating dampness; the tuckahoe helps the codonopsis pilosula to strengthen the spleen and eliminate dampness, and the four medicines are combined to be used as ministerial medicines. White peony root, radix Paeoniae alba nourishes blood and softens liver, astringes yin and combines ying, combines with radix Saposhnikoviae and radix rehmanniae, nourishes blood and dispels wind, wind-evil is killed automatically when blood circulation moves; the Chinese dates assist the white peony root and the cassia twig to regulate ying and wei, and the two medicines are adjuvant medicines. The liquorice is used for leading, the white paeony root is sour and sweet to transform yin so as to relieve the urgency, and the codonopsis pilosula is used for tonifying qi and strengthening spleen. The medicines are used together, so that the traditional Chinese medicine composition has the effects of dispelling wind and eliminating dampness, strengthening spleen and strengthening body resistance, and harmonizing yingfen and weifen, and has a good curative effect on spleen deficiency and damp-heat and wind-heat upward disturbance type allergic skin.
Detailed Description
The present section further details the above-described aspects of the present invention by way of examples. This should not be understood as limiting the scope of the above-described subject matter of the present invention to the following examples. All the technologies realized based on the above contents of the present invention belong to the scope of the present invention.
The sources and the effects of the traditional Chinese medicine raw materials used by the invention are as follows:
the preparation method comprises the following steps of (1) preparing the broom cypress fruit: is dried mature fruit of Kochia scoparia (L.) Schrad. Pungent, bitter and cold. It enters kidney and bladder meridians. Clear heat, promote diuresis, dispel wind and relieve itching. Can be used for treating difficult urination, pruritus vulvae, leukorrhagia, rubella, eczema, and skin pruritus.
Codonopsis pilosula: dried root of Codonopsis pilosula (Franch.) Nannf., codonopsis Pilosula Sp, var. Modesta (Nannf.) L.T.Shen or Codonopsis tandshen Oliv. Sweet and neutral. It enters spleen and lung meridians. To invigorate the spleen, benefit the lung, nourish blood and promote the production of body fluid. Can be used for treating deficiency of spleen-lung qi, anorexia, listlessness, cough, asthma, deficiency of qi and blood, sallow complexion, palpitation, short breath, thirst due to body fluid consumption, and internal heat.
Wind prevention: is dried root of Saposhnikovia divaricata (Turcz.) Schischk. Pungent, sweet and slightly warm. It enters bladder, liver and spleen meridians. Dispel wind and relieve exterior syndrome, resolve dampness and alleviate pain, stop spasm. Can be used for treating common cold, headache, rheumatalgia, rubella, pruritus, and tetanus.
Dried rehmannia root: is fresh or dried root tuber of Rehmannia Rehmannia glutinosa Libosch of Scrophulariaceae family. Sweet and cold in nature. It enters heart, liver and kidney meridians. Clear heat and cool blood, nourish yin and promote the production of body fluid. Can be used for treating heat entering nutrient-blood, epidemic febrile disease, macula, hematemesis, epistaxis, yin injury due to fever, crimson tongue, polydipsia, constipation due to body fluid consumption, fever due to yin deficiency, bone steaming, fatigue, internal heat, and diabetes.
Cassia twig: is dried twig of Cinnamomum cassia Presl of Lauraceae. Pungent, sweet and warm. It enters heart, lung and bladder meridians. Induce sweating and release muscles, warm and dredge meridians, strengthen yang and regulate qi, and smooth pulse and descend qi. Can be used for treating wind-cold type common cold, abdominal psychroalgia, blood cold, amenorrhea, arthralgia, phlegm retention, edema, palpitation, and galloping.
Poria cocos: is dried sclerotium of Wolf (Schw.) Wolf (Poria cocos) belonging to family Polyporaceae). Sweet, bland and mild. It enters heart, lung, spleen and kidney meridians. Induce diuresis and drain dampness, invigorate spleen and calm heart. Can be used for treating edema, oliguria, phlegm and fluid retention, dizziness, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia.
White peony root: is dried root of Paeonia lactiflora pall of Ranunculaceae. Bitter, sour and slightly cold. It enters liver and spleen meridians. Nourish blood and regulate menstruation, astringe yin and check sweating, soften liver and relieve pain, and calm liver yang. Can be used for treating blood deficiency, sallow complexion, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, abdominal pain, limb spasm pain, headache, and giddiness.
Chinese date: is dried mature fruit of Ziziphus jujuba Mill of Rhamnaceae. Sweet and warm. It enters spleen, stomach and heart meridians. Tonify qi, nourish blood and induce tranquilization. Can be used for treating spleen deficiency, anorexia, asthenia, loose stool, and hysteria of women.
Licorice root: is dried root and rhizome of Glycyrrhiza uralensis Fisch, glycyrrhiza inflata Bat, or Glycyrrhiza glabra L. Sweet and neutral. It enters heart, lung, spleen and stomach meridians. Invigorating spleen and replenishing qi, clearing away heat and toxic material, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the drugs. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature.
Example 1
An anti-allergic traditional Chinese medicine composition is prepared from the following raw materials: 40g of fructus kochiae, 30g of codonopsis pilosula, 25g of divaricate saposhnikovia root, 20g of radix rehmanniae recen, 20g of cassia twig, 20g of poria cocos, 15g of white paeony root, 10g of Chinese date and 8g of liquorice.
Example 2
An anti-allergic traditional Chinese medicine composition is prepared from the following raw materials: 50g of fructus kochiae, 50g of codonopsis pilosula, 40g of divaricate saposhnikovia root, 35g of radix rehmanniae recen, 30g of cassia twig, 30g of poria cocos, 25g of white paeony root, 20g of Chinese date and 15g of liquorice.
Example 3
An anti-allergic traditional Chinese medicine composition is prepared from the following raw materials: 40g of fructus kochiae, 30g of codonopsis pilosula, 30g of divaricate saposhnikovia root, 25g of radix rehmanniae recen, 20g of cassia twig, 20g of poria cocos, 18g of white paeony root, 12g of Chinese date and 8g of liquorice.
Example 4
An anti-allergic traditional Chinese medicine composition is prepared from the following raw materials: 45g of fructus kochiae, 40g of codonopsis pilosula, 40g of divaricate saposhnikovia root, 35g of radix rehmanniae recen, 25g of cassia twig, 25g of poria cocos, 25g of white paeony root, 15g of Chinese date and 12g of liquorice.
Example 5
An anti-allergic traditional Chinese medicine composition is prepared from the following raw materials: 45g of fructus kochiae, 38g of codonopsis pilosula, 35g of divaricate saposhnikovia root, 32g of radix rehmanniae recen, 25g of cassia twig, 25g of poria cocos, 20g of white paeony root, 15g of Chinese date and 10g of liquorice.
Example 6
An anti-allergic traditional Chinese medicine composition is prepared from the following raw materials: 48g of fructus kochiae, 35g of codonopsis pilosula, 28g of divaricate saposhnikovia root, 32g of radix rehmanniae recen, 25g of cassia twig, 25g of poria cocos, 18g of white paeony root, 12g of Chinese date and 12g of liquorice.
The traditional Chinese medicine compositions provided by the above embodiments 1 to 6 are all prepared according to the following method:
weighing Kochiae fructus, radix Codonopsis, radix Saposhnikoviae, radix rehmanniae, ramulus Cinnamomi, poria, radix Paeoniae alba, fructus Jujubae, and Glycyrrhrizae radix;
mixing the weighed traditional Chinese medicine raw materials, adding water with the weight 6 times of the total weight of the traditional Chinese medicine raw material mixture, decocting for 2 times, each time for 1.0h, combining the decoctions, and filtering to obtain the traditional Chinese medicine composition.
Example 7
An antiallergic traditional Chinese medicine composition is different from the traditional Chinese medicine composition in the embodiment 6 only in the preparation method, and specifically comprises the following steps:
weighing Kochiae fructus, radix Codonopsis, radix Saposhnikoviae, radix rehmanniae, ramulus Cinnamomi, poria, radix Paeoniae alba, fructus Jujubae, and Glycyrrhrizae radix;
mixing the weighed traditional Chinese medicine raw materials, adding water with the weight 10 times of the total weight of the traditional Chinese medicine raw material mixture, decocting for 3 times, each time for 2.0h, combining the decoctions, and filtering to obtain the traditional Chinese medicine composition.
The Chinese medicinal composition provided in the above example 1 can be further prepared into oral preparations or external preparations, such as granules, capsules, oral liquids or tablets, and ointments, sprays, patches, lotions, plastics or gels, according to pharmaceutically conventional methods. The gel preparation is described below as an example.
Example 8
An antiallergic gel is prepared by the following steps:
weighing 45g of fructus kochiae, 38g of codonopsis pilosula, 35g of divaricate saposhnikovia root, 32g of radix rehmanniae recen, 25g of cassia twig, 25g of poria cocos, 20g of white paeony root, 15g of Chinese date and 10g of liquorice for later use;
mixing the weighed traditional Chinese medicine raw materials, adding water which is 10 times of the total weight of the traditional Chinese medicine raw material mixture, decocting for 3 times, each time for 2.0h, combining the decoctions, filtering, and concentrating the filtrate to a relative density of 1.05 to obtain a traditional Chinese medicine extract;
adding propylene glycol into the Chinese medicinal extract, mixing, adding ethyl hydroxybenzoate ethanol solution, and stirring to obtain mixture A;
mixing sodium carboxymethylcellulose and polyvinyl alcohol, adding glycerol and deionized water, swelling at room temperature for 15h, mixing with mixture A, adding small amount of anhydrous ethanol, stirring, and supplementing deionized water to obtain Chinese medicinal gel;
wherein the mass fraction of each substance in the traditional Chinese medicine gel is as follows: 22% of traditional Chinese medicine extract, 8% of propylene glycol, 0.05% of ethylparaben, 2% of sodium carboxymethyl cellulose, 1.5% of polyvinyl alcohol, 2.5% of absolute ethyl alcohol and the balance of deionized water.
Comparative example 1
An anti-allergic traditional Chinese medicine composition is prepared from the following raw materials: 45g of fructus kochiae, 35g of divaricate saposhnikovia root, 32g of radix rehmanniae recen, 25g of cassia twig, 25g of poria cocos, 20g of radix paeoniae alba, 15g of Chinese date and 10g of liquorice.
Comparative example 2
An anti-allergic traditional Chinese medicine composition is prepared from the following raw materials: 38g of codonopsis pilosula, 35g of divaricate saposhnikovia root, 32g of radix rehmanniae recen, 25g of cassia twig, 25g of poria cocos, 20g of white paeony root, 15g of Chinese date and 10g of liquorice.
Comparative example 3
An anti-allergic traditional Chinese medicine composition is prepared from the following raw materials: 45g of fructus kochiae, 38g of codonopsis pilosula, 35g of divaricate saposhnikovia root, 25g of cassia twig, 25g of poria cocos, 20g of white paeony root, 15g of Chinese date and 10g of liquorice.
Comparative example 4
An anti-allergic traditional Chinese medicine composition is prepared from the following raw materials: 45g of fructus kochiae, 38g of codonopsis pilosula, 35g of divaricate saposhnikovia root, 32g of radix rehmanniae recen, 25g of cassia twig, 25g of poria cocos, 15g of Chinese date and 10g of liquorice.
Since the effect of the herbal composition prepared in examples 1 to 7 and the herbal gel provided in example 8 for anti-allergy are substantially the same, the effect will be described below by taking the herbal composition provided in example 5 as an example.
The following experiments were performed with reference to "pharmacodynamic study of magnesium isoglycyrrhizinate against mouse contact allergic dermatitis [ J ]. J.Chinese materia medica J.2010, 35 (10): 1311-1313.
1. Laboratory animal
SPF grade male mice, 100, weigh 22 + -5 g. The indoor temperature of the animals is (24 +/-2) ° C, the humidity is (50 +/-10)%, the illumination for 12 hours and the darkness for 12 hours are kept alternately, and the mice eat the standard feed and drink water at will to eat.
2. Modeling
And (4) establishing a mouse allergic dermatitis model by referring to pharmacological experimental methodology.
After the mice were raised for 1 week in the laboratory, the mice were subjected to abdominal depilation 1 day before the experiment in a range of about 3 cm. Times.3 cm, and the depilation site on the 1 st day of the experiment was uniformly sensitized by applying 1% of DNCB (1-chloro-2, 4-dinitrotoluene, 200. Mu.L) acetone-olive oil solution 1 time per day for 3 times in total, and repeatedly applied to the skin tissues on the back of both ears of the mice with 1% of DNCB (20. Mu.L) solution 1 time per day for excitation 1 time per day and 7 times in total on the 8 th to 16 th days of the experiment. The blank control group of mice 10 was only smeared with an equal volume of acetone olive oil (acetone to olive oil volume ratio of 4: 1) solution at the same time point.
3. Method of producing a composite material
90 modeled mice were randomly divided into a positive control group, a model group, a low dose group (2.4 mg/kg) of example 5, a medium dose group (4.8 mg/kg. D) of example 5, a high dose group (9.6 mg/kg. D) of example 5, a group (4.8 mg/kg. D) of comparative example 1, a group (4.8 mg/kg. D) of comparative example 2, a group (4.8 mg/kg. D) of comparative example 3 and a group (4.8 mg/kg. D) of comparative example 4, 10 mice per group. The mice in each group are subjected to intragastric administration of the corresponding drugs after sensitization according to the dose, the positive control group is administered with chlorphenamine maleate (5 mg/kg. D), and the model group is administered with physiological saline with the same volume. The remaining 10 mice were normally housed as a blank control group. The administration is continued for 7 days, and after 1h from the last administration, the orbital bleeding of each group of mice is followed by sacrifice, and the ears of the mice are fixed in a neutral paraformaldehyde solution with a mass fraction of 4%.
4. Detecting the index
4.1 degree of red swelling of mouse ear
Mice were tested for binaural swelling 24h after challenge and the degree of edema and erythema in the challenged ears were scored as follows:
0 minute: no erythema, 1 point: mild erythema, score 2: moderate erythema, score 3: severe erythema, score 4: edematous erythema; 0 minute: no edema, 1 point: mild edema, score 2: moderate edema, score 3: severe edema.
4.2 serum level detection
Taking isolated blood, centrifuging, collecting supernatant, and detecting the levels of IFN-gamma, igE and IL-6 in serum according to the ELISA kit specification.
5. Data processing
Statistical analysis of the data was performed using SPSS20.0 software. Data toIs represented by P<0.05 indicated significant differences.
6. Results
6.1 Effect on the degree of ear redness and swelling in mice
The results are shown in Table 1.
TABLE 1 degree of ear redness and swelling in groups of mice
Grouping | Swelling degree/mm | Erythema score | Edema score |
Blank control group | 0.01±0.02 | - | - |
Model set | 0.21±0.02 | 6.31±1.33 | 5.79±2.16 |
Positive control group | 0.15±0.04 | 4.14±2.09 | 4.31±1.05 |
Example 5 high dose group | 0.08±0.03 *# | 1.85±2.47 *# | 1.25±0.57 *# |
Practice ofDose groups in example 5 | 0.12±0.02 | 2.54±1.62 *# | 1.78±1.21 *# |
Example 5 Low dose group | 0.15±0.05 | 3.49±0.58 | 2.01±1.43 *# |
Comparative example 1 group | 0.15±0.07 | 3.58±1.21 | 2.57±1.89 |
Comparative example 2 group | 0.14±0.05 | 3.67±2.36 | 2.64±0.86 |
Comparative example 3 group | 0.12±0.02 | 3.06±2.59 * | 2.03±0.45 * |
Comparative example 4 group | 0.11±0.01 # | 3.29±1.65 | 1.96±1.28 *# |
Note: in comparison to the set of models, * P<0.05; compared with the positive control group, the composition has the advantages that, # P<0.05。
as can be seen from Table 1, the high, medium and low dose groups of example 5 and the groups of comparative examples 1 to 4 significantly inhibited the degree of ear swelling in mice and relieved the ear erythema and edema. Meanwhile, the high and medium dose groups of example 5 had significant effects of relieving ear swelling, erythema and edema in mice compared to the positive control group. The comparative examples 1-4 had slightly less relief than the high, medium and low dose groups of example 5. The traditional Chinese medicine composition provided by the invention is proved to be capable of obviously reducing the ear swelling degree of mice, and the raw materials are in a synergistic relationship.
6.2 Effect on mouse serum levels
The results are shown in Table 2.
TABLE 2 serum level assay for groups of mice
Grouping | IFN-γ(μg/mL) | IgE(μg/mL) | IL-6(μg/mL) |
Blank control group | 32.37±5.46 | 55.75±5.26 | 56.62±11.24 |
Model set | 96.21±7.81 | 101.51±6.73 | 117.49±12.33 |
Positive control group | 72.34±14.36 | 78.43±9.25 | 91.44±9.43 |
Example 5 high dose group | 38.59±9.43 *# | 58.13±5.42 *# | 62.58±7.43 *# |
Dose groups of example 5 | 42.33±7.52 *# | 61.29±7.15 * | 67.94±9.18 * |
Example 5 Low dose group | 47.83±11.34 | 70.13±6.33 | 75.43±10.24 * |
Comparative example 1 group | 49.32±8.45 | 75.34±8.99 | 69.27±8.57 |
Comparative example 2 group | 51.47±6.68 | 73.15±6.34 | 72.43±6.13 |
Comparative example 3 group | 45.79±8.35 *# | 69.21±9.21 * | 78.31±9.45 * |
Comparative example 4 group | 47.21±10.27 # | 66.22±7.92 * | 75.72±8.27 * |
Note: in comparison to the set of models, * P<0.05; compared with the positive control group, the composition has the advantages that, # P<0.05。
as can be seen from Table 2, the serum IFN-. Gamma.IgE, IL-6 levels were decreased in the mice of the high, medium and low dose groups of example 5 and the mice of the comparative examples 1 to 4. Compared with the model group, the high and medium dose groups of example 5 and the comparison groups 3 and 4 significantly inhibit the IFN-gamma, igE and IL-6 levels of serum; the high dose group of example 5 significantly suppressed serum IFN-. Gamma.IgE, IL-6 levels compared to the positive control group. The inhibition effect of the high, medium and low dose groups of example 5 was slightly better than that of each of the groups of comparative examples 1 to 4. The traditional Chinese medicine composition provided by the invention can reduce the changes of the mouse serum IFN-gamma, igE and IL-6 levels, has a good anti-allergic effect, and has a synergistic interaction relationship among the raw materials.
In conclusion, the traditional Chinese medicine composition provided by the invention has a better inhibition effect on allergic dermatitis.
The traditional Chinese medicine composition provided by the invention has no adverse reaction during use, and can be used as a candidate drug for development of an antiallergic drug.
While embodiments of the invention have been shown and described, it will be understood by those of ordinary skill in the art that: various changes, modifications, substitutions and alterations can be made to the embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.
Claims (10)
1. An anti-allergic traditional Chinese medicine composition is characterized by being prepared from the following raw materials in parts by weight: 40 to 50 parts of belvedere fruit, 30 to 50 parts of codonopsis pilosula, 25 to 40 parts of divaricate saposhnikovia root, 20 to 35 parts of radix rehmanniae recen, 20 to 30 parts of cassia twig, 20 to 30 parts of tuckahoe, 15 to 25 parts of white paeony root, 10 to 20 parts of Chinese date and 8 to 15 parts of liquorice.
2. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight: 40 to 45 portions of belvedere fruit, 30 to 40 portions of radix codonopsitis, 30 to 40 portions of divaricate saposhnikovia root, 25 to 35 portions of radix rehmanniae recen, 20 to 25 portions of cassia twig, 20 to 25 portions of tuckahoe, 18 to 25 portions of white paeony root, 12 to 15 portions of Chinese date and 8 to 12 portions of liquorice.
3. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight: 45 parts of fructus kochiae, 38 parts of codonopsis pilosula, 35 parts of divaricate saposhnikovia root, 32 parts of radix rehmanniae recen, 25 parts of cassia twig, 25 parts of poria cocos, 20 parts of white paeony root, 15 parts of Chinese date and 10 parts of liquorice.
4. A method for preparing the traditional Chinese medicine composition of any one of claims 1 to 3, which is characterized by comprising the following steps:
weighing belvedere fruit, codonopsis pilosula, divaricate saposhnikovia root, radix rehmanniae, cassia twig, poria cocos, white paeony root, chinese date and liquorice for later use;
mixing the weighed traditional Chinese medicine raw materials, adding water for decoction, and filtering decoction to obtain the traditional Chinese medicine composition.
5. The preparation method according to claim 4, wherein the specific process of decocting with water comprises: adding water which is 6-10 times of the total weight of the mixture of the traditional Chinese medicine raw materials, decocting for 2-3 times, 1.0-2.0 h each time, combining the decoction, and filtering to obtain the traditional Chinese medicine composition.
6. The preparation method of claim 5, wherein the Chinese medicinal composition can be further prepared into a pharmaceutically acceptable Chinese medicinal preparation.
7. The method of claim 6, wherein the Chinese medicinal preparation is an oral preparation or an external preparation.
8. The preparation method of claim 7, wherein the oral preparation is granules, capsules, oral liquid or tablets, and the external preparation is paste, spray, patch, lotion, plastics or gel.
9. An antiallergic traditional Chinese medicine gel is characterized by being prepared according to the following steps:
concentrating the traditional Chinese medicine composition prepared according to the claim 4 until the relative density is 1.05-1.10, adding auxiliary materials, and uniformly mixing to obtain traditional Chinese medicine gel;
the traditional Chinese medicine gel is prepared from the following raw materials in parts by mass: 20 to 28 percent of concentrate of the traditional Chinese medicine composition, 0.8 to 2.5 percent of matrix, 0.5 to 2.0 percent of film forming agent, 3 to 8 percent of humectant, 0.8 to 2.5 percent of penetration enhancer, 0.01 to 0.12 percent of preservative and the balance of water.
10. Use of the Chinese medicinal composition of any one of claims 1 to 3 in the preparation of a medicament for treating allergic dermatitis.
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