CN108434225A - A kind of Chinese medicine composition and its preparation method and application for treating senile skin itch - Google Patents
A kind of Chinese medicine composition and its preparation method and application for treating senile skin itch Download PDFInfo
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Abstract
The present invention provides a kind of Chinese medicine compositions for treating senile skin itch, it is the preparation that the bulk pharmaceutical chemicals matched by following weight are prepared：10 15 parts of kuh-seng, 10 15 parts of the root bark of shaggy-fruited dittany, 10 15 parts of frutus cnidii, 10 15 parts of the fruit of summer cypress, 10 15 parts of peppermint, 58 parts of Radix Glycyrrhizae, 15 parts of ganoderma lucidum, 15 parts of matsutake through water carry or organic solvent effective component extracting after be added and be made.The invention also discloses preparation method and uses.It is confirmed through animal experiment, this Chinese medicine composition energy heat-clearing and damp-drying drug, dispelling wind and arresting itching, quick in terms of preventing and treating senile skin itch, with strong points, cure rate is high, non-corrosive, has no toxic side effect, and has stronger clinical value.
Description
Technical field
The invention discloses a kind of Chinese medicine compositions, and in particular to a kind of Chinese medicine composition that treating senile skin itch and
Preparation method and use belongs to technical field of traditional Chinese medicines.
Background technology
" organic conception " is had been accepted as at present, " diagnosis and treatment based on an overall analysis of the illness and the patient's condition ", " compound use ", " compound compatibility medication is such as used military forces " are Chinese medicine
Most scientific most effective several big advantages, wherein " compound compatibility medication is such as used military forces " is the original theory of traditional Chinese medicine of very science.In
The tight compatibility that each medicine is all linked with one another as arraying troops for battle in prescription is cured, is that it is better than the effective means of western medicine formula.Chinese medicine
Prescription theory thinks that each prescription not only needs to select the suitable appropriate compatibility of drug according to etiology and pathogenesis, while should also meet
The basic structure of prescription, i.e. the prescription compatibility theory of " monarch minister, helps, makes ", the prescription compatibility of so-called " monarch minister, helps, makes " are exactly
It establishes the scientific matching on the comprehensive judgement basis to the disease interpretation of the cause, onset and process of an illness.
Senile skin itch mostly declines due to the skin technical ability of the elderly, and sebum secretion is reduced, and leads to the skin of the elderly
The reasons such as dry and degeneration atrophy and cause.Clinically very to itch, night itches again than daytime, is characterized more scratching more very to itch,
Belong to common disease, frequently-occurring disease, be more common in 60 years old or more old man, male's incidence is higher than women, and Chinese medicine becomes " pruritus " or " pruritus
Disease " has seriously affected the quality of life of the elderly.At present western medical treatment senile skin itch generally use Western medicine such as antihistamine,
Corticoid etc. since the toxic side effect of Western medicine is larger, and can lead to gerontal patient although certain effect can be obtained temporarily
Caput femoris necrosis（The side effect of hormone medicine）Adverse reactions are waited, thus the serious application for the treatment of for limiting gerontal patient
And curative effect, and it is easy recurrence.
Chinese medicine thinks that cutaneous pruritus is mainly caused by several reasons：1. it is damp and hot accumulate to relax in skin let out；2. deficiency of blood liver
Prosperous, life is dry humorously, and skin mistake is itched；3. liver and gallbladder damp-heat is betted.And the elderly's qi and blood is empty, cannot nourish skin, then has dry skin,
Degenerate, rheumatism causes itch from Nei Sheng, or with worn with age, liver-kidney Yin deficiency, be difficult skin of supplementing nutrition, deficiency of Yin blood it is dry pneumatic and
Cause is itched, or the wind-heat, chill, the damp and hot heresy that have are accumulate in skin, must not be relaxed and be let out and cause itch more than for a long time.Therefore it controls when with only
Based on itching, help with heat-clearing, removing toxic substances, wind-dispelling.
It is existing studies have shown that pruitus is a complicated, dynamic, continuous process, be a too many levels, more
The process of level, multifactor, multipath, multidigit point such as only treats some link, it is difficult to obtain ideal treatment
Effect.Theoretically, optimal treatment should be a variety of effects, the Drug combination of different pathological link, and traditional Chinese medicine
Using organic conception and diagnosis and treatment based on an overall analysis of the illness and the patient's condition as main feature, this thinking of exactly having coincide.
Invention content
The present invention provides a kind of Chinese medicine compositions and its preparation method and application for treating senile skin itch.
A kind of Chinese medicine composition for treating senile skin itch, it is that the bulk pharmaceutical chemicals matched by following weight are prepared
Preparation：10-15 parts of kuh-seng, 10-15 parts of the root bark of shaggy-fruited dittany, 10-15 parts of frutus cnidii, 10-15 parts of the fruit of summer cypress, 10-15 parts of peppermint, Radix Glycyrrhizae 5-
8 parts, 1-5 parts of ganoderma lucidum, 1-5 parts of matsutake.
Further, it is the preparation that the bulk pharmaceutical chemicals matched by following weight are prepared：12 parts of kuh-seng, the root bark of shaggy-fruited dittany 12
Part, 12 parts of frutus cnidii, 12 parts of the fruit of summer cypress, 12 parts of peppermint, 5 parts of Radix Glycyrrhizae, 1 part of ganoderma lucidum, 1 part of matsutake.
Further, it is matched for raw material by kuh-seng, the root bark of shaggy-fruited dittany, frutus cnidii, the fruit of summer cypress, peppermint, Radix Glycyrrhizae, ganoderma lucidum, matsutake
5 use, and are active constituent by wherein primary medicinal powder or water, extractive with organic solvent, pharmaceutically acceptable auxiliary material or auxiliary is added
The pharmaceutical preparation that helping property ingredient is prepared into.
Further, the pharmaceutical preparation is spray, lotion, paste, bath agent, liniment, capsule, granule, tablet.
Further, it is matched for raw material by kuh-seng, the root bark of shaggy-fruited dittany, frutus cnidii, the fruit of summer cypress, peppermint, Radix Glycyrrhizae, ganoderma lucidum, matsutake
5 use, and are active constituent by wherein primary medicinal powder or water, extractive with organic solvent, acceptable auxiliary material in daily chemical product is added
Or the daily chemical product that complementary ingredient is prepared into, the daily chemical product are water, breast, frost, film, soap.
Further, it is matched for raw material by kuh-seng, the root bark of shaggy-fruited dittany, frutus cnidii, the fruit of summer cypress, peppermint, Radix Glycyrrhizae, ganoderma lucidum, matsutake
5 use, and are active constituent by wherein primary medicinal powder or water, extractive with organic solvent, be added on cosmetics acceptable auxiliary material or
The cosmetics that complementary ingredient is prepared into, the cosmetics include toner, lotion, Essence, face cream, facial mask, eye mask, shower
Breast or shampoo.
A kind of preparation method of Chinese medicine composition that treating senile skin itch, includes the following steps：
（1）Prepare extract powder a：Kuh-seng is taken, the distilled water of 8 ~ 10 times of amounts is added to carry out decoction extraction, each 1-2h is extracted 1-3 times,
Reduced pressure drying is carried out after filtrate is merged, and obtains extract powder a；
（2）Prepare extract powder b：The root bark of shaggy-fruited dittany, frutus cnidii, the fruit of summer cypress, Radix Glycyrrhizae mixing are taken, the distilled water of 8 ~ 10 times of amounts is added to be decocted
Extraction, each 1-2h are extracted 1-3 times, carry out being concentrated under reduced pressure into the medicinal extract that relative density is 1.15 after filtrate is merged, in medicinal extract
Middle addition ethyl alcohol makes alcohol content reach 80wt%, stands 48h, and filtration takes supernatant, recycles ethyl alcohol, and the water of 4 times of volumes is added, fills
Divide and stir evenly, stand for 24 hours, centrifugal treating 30min takes supernatant, is condensed into the extract that proportion is 1.25, obtains extract powder b；
（3）Prepare extract powder c：Peppermint is taken, the distilled water of 8 ~ 10 times of amounts is added to use extraction by steam distillation volatile oil, each 1-
2h is extracted 1-3 times, gained volatile oil is embedded with cyclodextrin, drying is then concentrated under reduced pressure, obtains extract powder c；
（4）Prepare extract powder d：It takes ganoderma lucidum and matsutake dry product to crush and carries out refluxing extraction, add the 25-35 times of distilled water measured, 100
It extracts 2-3 hours, is filtered at DEG C, extract 2-4 times altogether, carry out reduced pressure drying after filtrate is merged, obtain extract powder d；
（5）Merge a, b, c, d extract powder, in addition pharmaceutically acceptable auxiliary material or complementary ingredient are prepared into pharmaceutically commonly
Preparation.
Further, the present invention also provides a kind of preparation method of Chinese medicine composition that treating senile skin itch, packets
Include following steps：
It counts by weight ratio, by 8-12 parts of medicinal material kuh-seng, 8-12 parts of the fruit of summer cypress, 8-12 parts of frutus cnidii, 8-12 parts of the root bark of shaggy-fruited dittany, thin
1-5 parts of 8-12 parts of lotus, 4-6 parts of Radix Glycyrrhizae, 1-5 parts of ganoderma lucidum, matsutake mixing, are added the water of 8-12 times of medicinal material weight, are 95- in temperature
It is decocted at 100 DEG C 2-3 times, 1.5 hours every time, filtration, merging filtrate, it was (50 DEG C of 1.10-1.20 to be concentrated into relative density）
Medicinal extract；Ethyl alcohol is added in medicinal extract makes alcohol content reach 80wt%, stands 48h, and filtration takes supernatant, recycles ethyl alcohol：It is added
The water of 3-5 times of volume, fully stirs evenly, and stands for 24 hours, and centrifugal treating 30min takes supernatant, and it is 1.20-1.30 to be condensed into proportion
Extract, it is spare.
The present invention also provides purposes of the above-mentioned Chinese medicine composition in treating senile skin itch.
In pharmaceutical composition of the present invention, kuh-seng is bitter, cold, energy heat-clearing and damp-drying drug, dispelling wind and arresting itching,《It does not record》It records " except volt
Heat ", " treating malignant sore ",《The southern regions of the Yunnan Province book on Chinese herbal medicine》It records its " controlling pruitus ", therefore is monarch drug in a prescription.Frutus cnidii removing toxic substances desinsection is antipruritic, eliminating dampness, dispels
Wind is usually used in eczema, mange；Root bark of shaggy-fruited dittany heat-clearing and damp-drying drug, dispelling wind and arresting itching, removing toxic substances, fruit of summer cypress clearing heat and promoting diuresis, dispelling wind and arresting itching are primary
In eczema, rubella, pruitus；Peppermint property is pungent, cool, return lung, Liver Channel, has the work(such as dispelling wind and heat from the body, head clearing, regulating the flow of vital energy Xie Yu
Effect.Peppermint external application can alleviate bite by mosquitos, boil etc.,《Compendium of Materia Medica》Record " peppermint it is pungent can diverging, it is cool can clear profit, specially in disappearing
Wind radiates." above-mentioned four traditional Chinese medicine object is altogether our ministerial drug, enhance heat-clearing and damp-drying drug, the work(of dispelling wind and arresting itching, principal drug assistance is directed to cardinal symptom
It is treated.Radix Glycyrrhizae is that medicine, coordinating the drug actions of a prescription is made to share the benefits of playing heat-clearing and damp-drying drug, dispelling wind and arresting itching altogether.Ganoderma lucidum is mild-natured, sweet in flavor, bitter,
Return lung, the heart, liver, the spleen channel, function mental-tranquilization, invigorating the lung and benefiting vital QI, nourishing liver and spleen, main component are ganoderma lucidum polysaccharide, ganoderic acid, gland
Glycosides and more than 10 kinds of alkali, oleic acid, cellulose, amino acid, trace element etc. can play the role of adjusting immunity well, in advance
Prevent the generation of various diseases.Matsutake is a kind of fungi of integration of drinking and medicinal herbs, containing a large amount of polysaccharide, agglutinin, deep and remote alcohols material,
The physiological activators such as amino acid, lipid and vitamin have the multiple actions such as immune enhancing, promotion marrow hemopoiesis, antitumor.
Complete square compatibility 5 uses, you can heat-clearing and damp-drying drug, wind dispelling insecticide, antipruritic convergence, each group flavour of a drug " positioning of determining a post ", post is clearly demarcated, mutually auxiliary
It coordinates, controls approach in addition and played analyze mentally sexology research side of the exclusive compound compatibility medication of traditional Chinese medicine as row army structures the formation
Method opinion has good curative effect to cutaneous pruritus especially senile skin pruritus.
Drug provided by the invention can be obviously improved the number of incidences of senile skin itch patient, be effectively prevented and treated old
Year pruitus, it is nontoxic, it is nonirritant, it is non-corrosive, there is stronger actual application value.
Obviously, the above according to the present invention is not being departed from according to the ordinary technical knowledge and customary means of this field
Under the premise of the above-mentioned basic fundamental thought of the present invention, the modification, replacement or change of other diversified forms can also be made.
The specific implementation mode of form by the following examples remakes further specifically the above of the present invention
It is bright.But the range that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to example below.It is all to be based on the above of the present invention
The technology realized all belongs to the scope of the present invention.
Specific implementation mode
Embodiment 1
A kind of medicine pill for treating senile skin itch
Kuh-seng 10kg is taken, 90kg distilled water is added and extracts, each 1h is extracted 3 times, is concentrated under reduced pressure after filtrate is merged
It is dry, obtain extract powder a；The root bark of shaggy-fruited dittany, frutus cnidii, the fruit of summer cypress each 10kg, Radix Glycyrrhizae 5kg is added, 280kg distilled water is added and is carried
It takes, each 1.5h, extracts 2 times, carry out being concentrated under reduced pressure into the medicinal extract that relative density is 1.15 after filtrate is merged, add in medicinal extract
Entering ethyl alcohol makes alcohol content reach 80wt%, stands 48h, and filtration takes supernatant, recycles ethyl alcohol, and the water of 4 times of volumes is added, fully stirs
It is even, it stands for 24 hours, centrifugal treating 30min takes supernatant, is condensed into the extract that proportion is 1.25, obtains extract powder b；Peppermint is added
10kg, the distilled water that 90kg is added use extraction by steam distillation volatile oil, each 1.5h to extract 2 times, by gained volatile oil
It is embedded with cyclodextrin, drying is then concentrated under reduced pressure, obtain extract powder c；Ganoderma lucidum and each 1kg crushing of matsutake dry product is taken to flow back
Extraction, is added the distilled water of 180kg, extracts 2.5 hours, be filtered at 100 DEG C, extracts 3 times, filtrate is merged laggard altogether
Drying is concentrated under reduced pressure in row, obtains extract powder d；Extract powder a, b, c, d are merged, stirred evenly, 50 DEG C is heated to and crosses 200 mesh sieve while hot
Filtration, filtrate are spray-dried to get spray powder, and spray drying condition is：90 DEG C of outlet temperature, 140 DEG C of inlet temperature, stream
Fast 0.6kg/min, 26 DEG C of feed temperature, is added appropriate maltodextrin, starch and honey, pill is made after mixing（Per ball
The mass ratio of middle a+b+c+d weighs about 30 ~ 40%）.
Embodiment 2
A kind of Chinese medicinal tablet for treating senile skin itch
Kuh-seng 10kg is taken, 90kg distilled water is added and extracts, each 1h is extracted 3 times, is concentrated under reduced pressure after filtrate is merged
It is dry, obtain extract powder a；The root bark of shaggy-fruited dittany, frutus cnidii, the fruit of summer cypress each 10kg, Radix Glycyrrhizae 5kg is added, 280kg distilled water is added and is carried
It takes, each 1.5h, extracts 2 times, carry out being concentrated under reduced pressure into the medicinal extract that relative density is 1.15 after filtrate is merged, add in medicinal extract
Entering ethyl alcohol makes alcohol content reach 80wt%, stands 48h, and filtration takes supernatant, recycles ethyl alcohol, and the water of 4 times of volumes is added, fully stirs
It is even, it stands for 24 hours, centrifugal treating 30min takes supernatant, is condensed into the extract that proportion is 1.25, obtains extract powder b；Peppermint is added
10kg, the distilled water that 90kg is added use extraction by steam distillation volatile oil, each 1.5h to extract 2 times, by gained volatile oil
It is embedded with cyclodextrin, drying is then concentrated under reduced pressure, obtain extract powder c；Ganoderma lucidum and each 1kg crushing of matsutake dry product is taken to flow back
Extraction, is added the distilled water of 180kg, extracts 2.5 hours, be filtered at 100 DEG C, extracts 3 times, filtrate is merged laggard altogether
Drying is concentrated under reduced pressure in row, obtains extract powder d；Extract powder a, b, c, d are merged, stirred evenly, 60 DEG C is heated to and crosses 200 mesh sieve while hot
Filtration, filtrate are spray-dried to get spray powder, and spray drying condition is：80 DEG C of outlet temperature, 130 DEG C of inlet temperature, stream
Fast 0.3kg/min, 25 DEG C of feed temperature, is added appropriate maltodextrin and magnesium stearate, is uniformly mixed, direct tablet compressing is to get piece
Agent（The mass ratio of every middle a+b+c+d weighs about 20 ~ 30%）.
Embodiment 3
A kind of Chinese medicine composition for treating senile skin itch
By kuh-seng 8-12g, fruit of summer cypress 8-12g, frutus cnidii 8-12g, root bark of shaggy-fruited dittany 8-12g, peppermint 8-12 g, Radix Glycyrrhizae 4-6 g, ganoderma lucidum
1-5 g, matsutake 1-5 g mixing, are added the water of 8-12 times of medicinal material weight, decoct 2-3 times at being 95-100 DEG C in temperature, every time
1.5 hours, filtration, merging filtrate, it was (50 DEG C of 1.10-1.20 to be concentrated into relative density）Medicinal extract；Second is added in medicinal extract
Alcohol makes alcohol content reach 80wt%, stands 48h, and filtration takes supernatant, recycles ethyl alcohol：The water of 3-5 times of volume is added, fully stirs
It is even, it stands for 24 hours, centrifugal treating 30min takes supernatant, is condensed into the extract that proportion is 1.20-1.30, spare.
Comparative example 1
A kind of medicine pill for treating senile skin itch
The preparation method is the same as that of Example 1, only without matsutake in Chinese medicine composition.
Comparative example 2
A kind of medicine pill for treating senile skin itch
The preparation method is the same as that of Example 1, only without ganoderma lucidum in Chinese medicine composition.
Comparative example 3
A kind of medicine pill for treating senile skin itch
The preparation method is the same as that of Example 1, only without matsutake and ganoderma lucidum in Chinese medicine composition.
Hereinafter beneficial effects of the present invention are proved with the mode of experimental example：
The effect of prevention of 1 daily chemical product of the present invention of test example and Chinese medicine composition and treatment senile skin itch, tests
1, experimental animal
Take SPF grades of ICR male mices 60, weight（23.7±0.16）G is randomly divided into 6 groups, every group 10.
2, trial drug and dosage regimen
4 groups of mouse are taken to be labeled as 3 groups of 1 group of embodiment, 1 group of comparative example, 2 groups of comparative example and comparative example, all mouse are given pair
Extract gavage is answered to handle, l.6g/kg dosage is.
In addition it takes 1 group of mouse as positive controls, gives WUSHE ZHIYANG WAN（Chinese medicines quasi-word Z44020044, Jiangxi Qing Feng
Pharmaceutcal corporation, Ltd）, dosage lg/kg.
In addition take 1 group of mouse as model control group, this group of mouse does not give any drug-treated.
3, experimental method
In before modeling 7 days, each administration group pressed 0.2ml/10g weight gastric infusions every time（Pill is first added a small amount of water grind, after
It is 0.08gml aquas to add water constant volume）, 1 time/d, continuous 7d, model control group is with distilled water gavage.After 7d last doses lh,
To 0. 025% dextran-40 of each group mouse tail vein injection, dosage 0.05ml/10g.With mouse fore paw scratching head, after
Pawl scratching trunk, mouth sting whole body each section as itch indication.
4, test result
The present composition to the mouse model antipruritic Effect study result of dextran-40 inducing endogenous histamine release such as
Shown in the following table 1.
Antipruritic effect compares after 1 each group mouse medication of table
。
Note：Compared with 1 group of embodiment, * P ＜ 0. 05, * * P ＜ 0. 01.
Antipruritic effect can be evaluated by the latent time and itch number of second of itch appearance.Latent time can
To reflect that the speed of endogenous histamine release, itch number then reflect the intensity and duration of endogenous histamine release.By upper table 1
It is found that 1 group of embodiment, 1 group of comparative example, 2 groups of comparative example, 3 groups of comparative example and positive controls occur itch number, when continuing
Between number be significantly lower than model control group, difference is statistically significant（P<0.01）, 1 group of embodiment goes out compared to positive controls
The number of existing itch is lower with duration, meanwhile, 1 group of embodiment is compared with containing 1 group of ganoderma lucidum comparative example and containing matsutake
2 groups of example compares the number for itch occur and duration is lower；Containing 1 group of ganoderma lucidum comparative example and contain matsutake comparative example 2
Group the number of itch occurs compared with 3 groups of the comparative example without ganoderma lucidum and matsutake and duration is also lower；Not only illustrate
Embodiment 1 has good antipruritic effect to the mouse model of dextran-40 inducing endogenous histamine release, can obviously subtract
When young mouse itch number significantly reduces the itch duration；Be also presented by matsutake and ganoderma lucidum be added together kuh-seng, the fruit of summer cypress,
In frutus cnidii, the root bark of shaggy-fruited dittany, peppermint, Radix Glycyrrhizae, mouse itch number can be significantly reduced, significantly reduces the itch duration, and antipruritic
Significant effect is better than being individually added into matsutake, being individually added into ganoderma lucidum.Illustrate mutual compatibility of this composition by different Chinese medicines, meets
Traditional Chinese medical theory has played synergistic function, obtains more preferably itching-relieving efficacies.
2 present composition of test example prevents and the experiment for the treatment of senile skin itch
1, experiment material
1.1 experimental drug
Pharmaceutical composition of the present invention, the Chinese medicinal tablet that selection example 2 is prepared.
1.2 patient data
60 senile pruritus patients are research object, are randomly divided into observation group and control group, each 30.Observation group man 17
Example, female l3, average age（66.2±4.2）Year；Average course of disease（3.8±2.3）Year.Control group man 16, female 14；It is average
Age（66.5±4.1）Year, average course of disease（3.9±2.1）Year.Two groups of patient's general information compare, no significant difference,
It is comparable（P>0.05）.
2, experimental method
2.1 therapy
Control group patient is treated using conventional western medicine, i.e., daily 1 Desloratadine piece of per os hora somni（Producer：Shenzhen beach
Pharmaceutical Co. Ltd；Authentication code：Chinese medicines quasi-word H20020091）, 5mg/ times, 1 course for the treatment of was 3 week.Observation group patient takes
Chinese medicinal tablet is prepared with by embodiment 2,1/d, 1 course for the treatment of was 3 week.Two groups of patients, 1 course for the treatment of of equal continued treatment.
Other drugs are not used during treatment, not edible seafood and irritable food eat fresh fruit and vegetables more, drink water more, no
It smokes, drink, do not have to soap and have a bath.
2.2 observation index
It observes two groups of patients and treats forward and backward pruritis integral situation of change and somatic feature score situation of change.Pruritis：0 point
For no itch；3 points are slight itch, can be endured, can normal life and work；6 points are moderate itch, can be endured, but portion
Dividing influences life and work；9 points are severe itch, are impatient at, have a significant effect to living and working.Sign：Including fash
Area, scab, drying, tongue freshization, the scales of skin that peel off, papule, scratch situation；0 point for no skin lichenification, it is not dry, without the scales of skin that peel off,
There is no scab and scratch；1 point for there are unconspicuous limitation lichenification, it is slight dry, there are a small amount of scales of skin that peel off, locally lie in
Less scab and scratch；2 points for occur moderate lichenification, moderate be dry, skin there are tight feeling, there is sheet squama
There is scab and scratch in bits, multiple positions；3 points are the more lichenification of appearance, and there are plump skin lesion, severes to dry, skin
It chaps, and has feeling of pain, the scales of skin that peel off apparent, whole body that falls off has scab and scratch.It is primary to treat forward and backward each evaluation, disease
Shape integral declines index=[difference/prior treatment integral of integral before and after treatment] × 100%.
2.3 the standard of curative effect evaluation
Recovery from illness：Pruritis completely disappears, and secondary skin lesion includes that scab, furfur and drying etc. are subsided completely, and symptom integral refers to
Number decrease beyond 90%；It is effective：Pruritis largely disappears, and secondary skin lesion includes that scab, furfur and drying etc. are most of
Subside, symptom integral index decreased 70% ~ 90%；It improves：Pruritis is improved, secondary skin lesion include scab, furfur with
And the fractions such as dry subside, symptom integral index decreased 30% ~ 70%；In vain：Pretherapy and post-treatment symptom, sign obviously do not become
Change, symptom integral index decreased is less than 30%；Total effective rate=（Recovery from illness+effective+improve）/ number of cases × 100.0%.
2.4 data statistics
Data are handled using SPSS19.0 statistics softwares, measurement data is with indicating, examined with t, enumeration data is indicated with n/%,
With chi-square criterion, with P<0.05 has statistical significance for difference.
3 experimental results
3.1 two groups of patient outcomes compare
The total effective rate of observation group patient is 94.34%, hence it is evident that is higher than the 67.76% of control group, difference is statistically significant（P<
0.05）.Experimental result is as shown in table 2：
2 two groups of patient outcomes of table compare（n；% ）
。
Note：Compared with the control group, * P ＜ 0.05.
3.2 two groups of patients treat forward and backward symptom integral and compare
Before treatment, two groups of patient's pruritis integrals and somatic feature score compare no significant difference（P>0.05）；After treatment, two groups of trouble
The overworked symptom integral of person's scabies and somatic feature score are remarkably decreased, and observation group's fall is significantly greater than control group, and difference has statistics
Learn meaning（P<0.05）.Experimental result is as shown in table 3：
3 two groups of patients of table treat forward and backward symptom integral and compare
。
Note：Compared with before same group for the treatment of, * P ＜ 0.05；Compared with after control group treatment, #P ＜ 0.05.
The safety test of 3 daily chemical product composition of the present invention of test example
Using《Cosmetics health specification》In " acute oral toxicity test ", " acute dermal toxicity experiment ", " skin Eye irritation
Property/corrosion test ", " acute eye irritation/corrosion test ", " Skin allergy test ", " skin phototoxicity experiment "
Safety evaluatio is carried out to daily cosmetics of the present invention, test result shows that daily cosmetics of the present invention belong to nontoxic, stingless
Swash property, non-corrosive external application raw material, can be used in cosmetics.
In conclusion daily chemical product provided by the invention and Chinese medicine composition can prevent and treat senile skin itch, needle
Strong to property, cure rate is high, non-corrosive, has no toxic side effect, and has stronger actual application value.
Claims (9)
1. a kind of Chinese medicine composition for treating senile skin itch, which is characterized in that it is the bulk pharmaceutical chemicals matched by following weight
The preparation being prepared：10-15 parts of kuh-seng, 10-15 parts of the root bark of shaggy-fruited dittany, 10-15 parts of frutus cnidii, 10-15 parts of the fruit of summer cypress, peppermint 10-
15 parts, 5-8 parts of Radix Glycyrrhizae, 1-5 parts of ganoderma lucidum, 1-5 parts of matsutake.
2. Chinese medicine composition according to claim 1, which is characterized in that it be the bulk pharmaceutical chemicals matched by following weight prepare and
At preparation：12 parts of kuh-seng, 12 parts of the root bark of shaggy-fruited dittany, 12 parts of frutus cnidii, 12 parts of the fruit of summer cypress, 12 parts of peppermint, 5 parts of Radix Glycyrrhizae, 1 part of ganoderma lucidum,
1 part of matsutake.
3. Chinese medicine composition according to claim 1 or 2, which is characterized in that it be by kuh-seng, the root bark of shaggy-fruited dittany, frutus cnidii,
Skin, peppermint, Radix Glycyrrhizae, ganoderma lucidum, matsutake are that material combination uses, and are to live by wherein primary medicinal powder or water, extractive with organic solvent
Property ingredient, is added the pharmaceutical preparation that pharmaceutically acceptable auxiliary material or complementary ingredient are prepared into.
4. Chinese medicine composition according to claim 3, which is characterized in that the pharmaceutical preparation be spray, lotion, paste,
Bathe agent, liniment, capsule, granule, tablet.
5. Chinese medicine composition according to claim 1 or 2, which is characterized in that it be by kuh-seng, the root bark of shaggy-fruited dittany, frutus cnidii,
Skin, peppermint, Radix Glycyrrhizae, ganoderma lucidum, matsutake are that material combination uses, and are to live by wherein primary medicinal powder or water, extractive with organic solvent
Property ingredient, the daily chemical product that is prepared into of acceptable auxiliary material or complementary ingredient in daily chemical product is added, the daily chemical product is
Water, breast, frost, film, soap.
6. Chinese medicine composition according to claim 1 or 2, which is characterized in that it be by kuh-seng, the root bark of shaggy-fruited dittany, frutus cnidii,
Skin, peppermint, Radix Glycyrrhizae, ganoderma lucidum, matsutake are that material combination uses, and are to live by wherein primary medicinal powder or water, extractive with organic solvent
Property ingredient, the cosmetics that are prepared into of acceptable auxiliary material or complementary ingredient on cosmetics are added, the cosmetics include skin toner
Water, lotion, Essence, face cream, facial mask, eye mask, bath oil or shampoo.
7. a kind of preparation method of Chinese medicine composition according to claim 1 or 2, which is characterized in that this method include with
Lower step：
（1）Prepare extract powder a：Kuh-seng is taken, 8 ~ 10 times of amount distilled water is added to carry out decoction extraction, each 1-2h is extracted 1-3 times, will
Filtrate carries out reduced pressure drying after merging, and obtains extract powder a；
（2）Prepare extract powder b：The root bark of shaggy-fruited dittany, frutus cnidii, the fruit of summer cypress, Radix Glycyrrhizae mixing are taken, adds 8 ~ 10 times of amount distilled water to carry out decoction and carries
It takes, each 1-2h, extracts 1-3 times, carry out being concentrated under reduced pressure into the medicinal extract that relative density is 1.15 after filtrate is merged, in medicinal extract
Ethyl alcohol, which is added, makes alcohol content reach 80wt%, stands 48h, and filtration takes supernatant, recycles ethyl alcohol, the water of 4 times of volumes is added, fully
It stirs evenly, stands for 24 hours, centrifugal treating 30min takes supernatant, is condensed into the extract that proportion is 1.25, obtains extract powder b；
（3）Prepare extract powder c：Peppermint is taken, 8 ~ 10 times of amount distilled water is added to use extraction by steam distillation volatile oil, each 1-
2h is extracted 1-3 times, gained volatile oil is embedded with cyclodextrin, drying is then concentrated under reduced pressure, obtains extract powder c；
（4）Prepare extract powder d：It takes ganoderma lucidum and matsutake dry product to crush and carries out refluxing extraction, add the 25-35 times of distilled water measured, 100
It extracts 2-3 hours, is filtered at DEG C, extract 2-4 times altogether, carry out reduced pressure drying after filtrate is merged, obtain extract powder d；
（5）Merge a, b, c, d extract powder, in addition pharmaceutically acceptable auxiliary material or complementary ingredient are prepared into pharmaceutically commonly
Preparation.
8. a kind of preparation method of Chinese medicine composition that treating senile skin itch, which is characterized in that this method includes following step
Suddenly：
It counts by weight ratio, by 8-12 parts of medicinal material kuh-seng, 8-12 parts of the fruit of summer cypress, 8-12 parts of frutus cnidii, 8-12 parts of the root bark of shaggy-fruited dittany, thin
1-5 parts of 8-12 parts of lotus, 4-6 parts of Radix Glycyrrhizae, 1-5 parts of ganoderma lucidum, matsutake mixing, are added the water of 8-12 times of medicinal material weight, are 95- in temperature
It is decocted at 100 DEG C 2-3 times, 1.5 hours every time, filtration, merging filtrate, it was (50 DEG C of 1.10-1.20 to be concentrated into relative density）
Medicinal extract；Ethyl alcohol is added in medicinal extract makes alcohol content reach 80wt%, stands 48h, and filtration takes supernatant, recycles ethyl alcohol：It is added
The water of 3-5 times of volume, fully stirs evenly, and stands for 24 hours, and centrifugal treating 30min takes supernatant, and it is 1.20-1.30 to be condensed into proportion
Extract, it is spare.
9. Chinese medicine composition made from preparation method according to claim 7 or 8 is preparing treatment senile skin itch medicine
Purposes in object.
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| CN112641849A (en) * | 2020-12-28 | 2021-04-13 | 成都市康飞药业有限公司 | Pharmaceutical or cosmetic composition for dry skin, and preparation method and application thereof |
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| CN103479737A (en) * | 2013-08-06 | 2014-01-01 | 上海市闸北区中医医院 | Traditional Chinese medicine composition for treating senile cutaneous pruritus and application thereof |
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| CN110129150A (en) * | 2019-05-23 | 2019-08-16 | 刘金钊 | One kind, which has, alleviates pruitus, beriberoid pyretic arthralgia, the Chinese medicine handmade soap and preparation method thereof of scabies sore leprosy symptom effect |
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