CN115337346A - A Chinese medicinal composition for treating opioid addiction, and its preparation method - Google Patents

Abstract

The invention discloses a drug-dropping Chinese medicine prescription for treating opioid addiction and a preparation method thereof, comprising the following Chinese medicine raw materials: 10 to 20 parts of ginseng, 40 to 60 parts of astragalus, 4 to 8 parts of American ginseng, 4 to 8 parts of prepared monkshood, 20 to 40 parts of salvia miltiorrhiza, 20 to 40 parts of spina date seed, 20 to 40 parts of schisandra chinensis, 10 to 20 parts of coptis chinensis, 6 to 12 parts of dried orange peel and 20 to 40 parts of honey-fried licorice root.

Description

A Chinese medicinal composition for treating opioid addiction, and its preparation method

Technical Field

The present invention relates to the field of Chinese medicine, and is especially one kind of Chinese medicine for treating opium addiction and its preparation process.

Background

The Chinese medicine for stopping drug addiction has a long history, and Chinese medicine for stopping drug addiction in the end of 18 th century has formed a set of complete theories of healthy body balance of yin and yang and sufficient qi and blood. After the drugs enter the human body, yin and yang imbalance and qi and blood deficiency are caused, damp turbidity is generated endogenously, all passages of the whole body are blocked, and then heart orifice is blocked, even all functions of the whole body are in disorder. To achieve the purpose of drug rehabilitation, yin and yang regulation and heart resuscitation promotion are required. Ancient Chinese medicine has accumulated abundant and precious experiences in treating drug addiction, and Qing dynasty Yingxiong forest is one example of the drug addiction. The use of Chinese medicinal drug-relief medicine has already been started at the end of 18 th century in China, and the most widely used medicine includes smoking-stopping pill, sour-avoiding pill and tonic pill, and the Datura dropping pill appears in Shanxi province after 30 years in 20 th century. With the development and abuse of chemical drugs, particularly addiction to opiates is one of the current problems of narcotic abuse worldwide and is also a public nuisance. How to quit drug addiction is an important task of current drug inhibition work. The drug-dropping methods used in western medicine have disadvantages. For example, methadone, which is the first choice of opioid, has good effect of eliminating withdrawal symptoms, but has dependence on the methadone itself and is easy to generate 'poison by poison'. Other non-opioid drugs, such as clonidine and verapamil, have many side effects and unsatisfactory therapeutic effects.

Disclosure of Invention

In order to treat the problem of opioid drug addiction, the invention provides a drug-relief traditional Chinese medicine prescription for treating opioid drug addiction, which can be prepared into decoction, granules, capsules, tablets, oral liquid, spray, injection and aerosol, and can calm the nerves, relieve restlessness, clear away heat and toxic material, relieve pain, promote urination and tonify the spleen and the stomach, thereby achieving the purposes of strengthening the body resistance and eliminating evil, regulating central nervous system disorder, correcting intractable insomnia and enhancing the whole immunity effect of the organism.

The invention provides a drug-dropping traditional Chinese medicine prescription for treating opioid addiction, which comprises the following traditional Chinese medicine raw materials: ginseng, astragalus root, american ginseng, prepared aconite root, salvia root, spiny jujube kernel, schisandra fruit, coptis root, tangerine peel and honey-fried licorice root.

According to different clinical symptoms, the formula comprises the following components in parts by weight: 10 to 20 portions of ginseng, 40 to 60 portions of astragalus root, 4 to 8 portions of American ginseng, 4 to 8 portions of prepared aconite root, 20 to 40 portions of salvia miltiorrhiza, 20 to 40 portions of spina date seed, 20 to 40 portions of schisandra chinensis, 10 to 20 portions of coptis chinensis, 6 to 12 portions of dried orange peel and 20 to 40 portions of honey-fried licorice root.

As a priority: 10 or 15 or 20 parts of ginseng, 40 or 50 or 60 parts of astragalus root, 4 or 5 or 8 parts of American ginseng, 4 or 5 or 8 parts of prepared common monkshood daughter root, 20 or 30 or 40 parts of salvia miltiorrhiza, 20 or 30 or 40 parts of spina date seed, 20 or 30 or 40 parts of Chinese magnoliavine fruit, 10 or 15 or 20 parts of coptis chinensis, 6 or 10 or 12 parts of dried orange peel and 20 or 30 or 40 parts of honey-fried licorice root.

The Chinese medicinal composition can be made into various dosage forms such as decoction, granule, capsule, tablet, oral liquid, pill, gel, spray, atomized liquid, injection, etc. by adding adjuvants.

The preparation method of the drug-relief traditional Chinese medicine prescription for treating opioid addiction comprises the following steps: pulverizing radix Panacis Quinquefolii into fine powder, and sieving; decocting the rest ginseng, astragalus, prepared monkshood, salvia miltiorrhiza, spina date seed, schisandra chinensis, coptis chinensis, dried orange peel and honey-fried licorice root with water twice for 3 hours for the first time and 2 hours for the second time, merging decoction, filtering, concentrating filtrate into clear paste with the relative density of 1.20-1.25 (80 ℃), mixing with tuckahoe powder and the American ginseng powder uniformly, drying, crushing, sieving, making pills with water, and drying at low temperature to obtain the traditional Chinese medicine.

On the other hand, the advantages of micro traditional Chinese medicine and aerosol inhalation are combined, the aerosol medicine can be directly delivered to the affected part by utilizing the aerosol inhalation, and the effect can be quickly achieved; the atomization administration is local targeted administration, can completely or partially replace systemic administration, and improves the bioavailability of the medicament. The invention also provides a method for preparing the atomizing agent liquid medicine by adopting the prescription, which comprises the following steps:

s1: weighing the raw material medicines in the formula according to the parts by weight;

s2: respectively crushing and breaking the walls of the raw material medicines to obtain raw material medicine powder with at least partial nanometer size;

s3: boiling the bulk drug powder in water, keeping warm immersion for 1-3 times at 60-90 ℃ for 2-3 hours each time, combining the leaching solution, and filtering to obtain an extracting solution;

s4: drying and dispersing the extracting solution to obtain nanoscale raw medicinal powder;

s5: dissolving the nanometer raw material powder in an atomizing matrix to obtain the atomizing agent liquid medicine.

The raw materials weighed according to the formula can be mixed and then crushed, or respectively crushed and then mixed, and according to different properties of the traditional Chinese medicines, the raw materials can be crushed and then mixed according to different combinations. The pulverization can adopt the conventional traditional Chinese medicine pulverization technology, such as mechanical pulverization technology, ultrasonic pulverization technology, jet milling technology and the like, as long as the raw material medicines can form nano medicinal powder, and the cell wall is crushed, thereby being beneficial to dissolving out the effective components.

The raw material medicine extracting solution can be obtained by adopting a common traditional Chinese medicine extracting technology to obtain the effective components of the traditional Chinese medicine. Wherein the extractant can be water or organic extractant.

Wherein, the extract is dried by freeze drying; spray drying techniques may also be used. The dried raw material powder is preferably dispersed to obtain well-dispersed raw material powder; the dispersion can be carried out mechanically, for example by means of a jet mill; chemical methods such as surface modification and the like may also be employed.

In some embodiments, the nano-scale raw medicinal powder has a specific gravity of not more than 2% in the atomizing agent. The atomizing matrix at least comprises water solution and/or propylene glycol and/or glycerin for dissolving the nano-scale raw medicinal powder. The water solution is prepared by dissolving nanometer medicinal powder in hot water at a temperature higher than 50 deg.C. The proportion of the nano-scale raw material powder in the aqueous solution is 0.5-20%.

Wherein the raw medicinal powder is dissolved in the nebulizing matrix, preferably the raw medicinal powder is first dissolved in water, for example to form an aqueous solution with a concentration of 1.5% or 2% by weight, i.e. the nebulized stock solution. Then, the atomized raw materials are added into the atomized matrix according to the proportion and are uniformly mixed to obtain atomized liquid medicine.

Of course, the nebulized stock solution may also be in other concentrations, for example in the interval of 0.5% to 2%, such as 1.8%, 1.7%,1.6%,1.4%,1.3%,1.2%,1.1%,1.0%,0.8%,0.7%,0.6%,0.5% or any combination of the above concentrations. The weight proportion of water in the atomized liquid medicine is not more than 10wt%, for example, 1.5wt% of atomized stock solution is added into 10 times of atomized base material by weight to obtain atomized liquid medicine.

Furthermore, the dissolution is preferably in hot water, for example in hot water at more than 50 degrees celsius. Of course, other temperatures of water are possible, such as 55 ℃,60 ℃,65 ℃,70 ℃,75 ℃,80 ℃,85 ℃,90 ℃,95 ℃,100 ℃, or any combination of the above temperatures. Higher temperature is favorable for dissolving the raw medicinal powder, and overhigh temperature is not favorable for saving energy.

The nebulizing matrix comprises propylene glycol and/or glycerol. The propylene glycol is food and drug additive, comprises 1,2 propylene glycol and 1,3 propylene glycol, is used for adjusting the atomization temperature of atomized liquid medicine, and enters into atomized aerosol as carrier of effective components of medicine. Glycerol is the main component for generating the aerosol, and commonly used glycerol includes vegetable glycerol. It is also a routine choice to use a mixture of the two.

By utilizing the heating atomization system in the prior art, atomized liquid medicine reaches the vicinity of the boiling point through electric heating to form aerosol. The electric heating atomization system mainly comprises an atomizer, a battery and a control element, and the principle of generating aerosol is that atomized liquid is gasified on an electric heating element of the electric atomization system into high-temperature steam to be sprayed out from an opening end, the sprayed steam expands and condenses into tiny droplets in the atmosphere, the particle size of most of the generated aerosol is less than or equal to 1 mu m, and most of the aerosol deposits in bronchioles and lungs, so that the electric heating atomization system is suitable for drug administration in lower respiratory tracts and lungs. The electronic heating atomization system can be in an active suction type, the heating system is activated through active suction of a patient, atomized liquid medicine aerosol is inhaled, and the use compliance of consumers can be enhanced.

The heating atomization system can also be a vibration mesh screen atomization system, and the device can make the liquid medicine pass through the fine mesh to generate the medicine fog through the low-frequency vibration of the piezoelectric ceramic piece, so that the influence of the heat generation of the high-frequency ultrasonic vibration liquid on the medicine can be reduced. The diameter of the mesh can determine the size of the particles generating the mist. The vibrating screen hole atomizer has high atomization efficiency and small residual drug amount (0.1-0.5 mL), and has the advantages of low noise, small size, light weight and the like. The system may also be a pressurized metered dose aerosol inhaler, a jet nebulizer, or the like. As long as the atomized liquid medicine can be atomized to form an aerosol which can be inhaled into the respiratory system.

First, the major active ingredient of opium is morphine (about 10%), which is first excited and then inhibited but mainly inhibited in the central nervous system. Morphine first inhibits the higher centers of the cerebral cortex, later on is involved in brain extension, respiratory center inhibition and excitable and emetic chemosensory areas. Morphine can enhance the excitation of spinal cord, increase the tension of gastrointestinal smooth muscle and its sphincter, reduce intestinal peristalsis, and has similar effect on bronchial, biliary and ureteral smooth muscle. High doses of morphine have been shown to inhibit the motor center of medullary vessels and to release histamine, causing peripheral vessels to dilate, resulting in hypotension and bradycardia. Large or frequent administration of morphine for one misuse can lead to poisoning. The long-term use of morphine can cause euphoria and addiction. The patients with chronic diseases such as liver disease, emphysema, bronchial asthma, anemia, thyroid gland or chronic adrenocortical insufficiency are all easy to be poisoned. Patients with mild acute poisoning have headache, dizziness, nausea, emesis, excitation or depression, and patients have fantasy, loss of time and space sensation, constipation, urine retention, and high blood sugar level. Chronic poisoning is manifested as loss of appetite, constipation, emaciation, insomnia, and collapse.

According to the clinical symptoms and the change conditions of etiology and pathogenesis, the compatibility of the invention is based on the eight-principle dialectical theory of traditional Chinese medicine, utilizes the four-qi five-flavor of the prescription medicine and the deviation of ascending, descending, sinking and floating medicine properties to correct the deviation of human body, and forms a raw medicine formula according to monarch, minister, assistant and guide.

The method comprises the following steps: ginseng has the effects of invigorating primordial qi, recovering pulse, relieving depletion, invigorating spleen, benefiting lung, promoting fluid production, nourishing blood, tranquilizing mind and improving intelligence, and radix Glycyrrhizae Preparata is added for treating weakness of spleen and stomach, listlessness, debilitation, palpitation and intermittent pulse, and can be used for treating heart qi deficiency syndrome.

The astragalus has the main effects of tonifying qi and strengthening yang, consolidating superficial resistance and arresting sweating, inducing diuresis and reducing edema, promoting the production of body fluid and nourishing blood, expelling toxin and expelling pus and the like, has good curative effect when the resistance is reduced and the anorexia is caused, and has the functions of tonifying qi and nourishing yin, clearing fire and promoting the production of body fluid by matching with the bitter taste, slight sweet taste and cold nature of the American ginseng, and the ginseng has the functions of tonifying qi and nourishing yin, and nourishing the body fluid by entering heart, lung and kidney channels; the Saviae Miltiorrhizae radix has effects of dilating peripheral blood vessel, improving myocardial ischemia, improving microcirculation, promoting blood circulation, dispelling blood stasis, regulating qi-flowing and relieving pain; prepared aconite has the efficacies of dispelling cold, relieving pain, tonifying kidney yang and the like, so the prepared aconite is a ministerial medicine of the recipe.

Spina date seed has the effects of calming heart and soothing nerves, can help sleep, and relieve the mood of tension, anxiety and depression, and schisandra chinensis has the functions of astringing and arresting discharge, tonifying qi and promoting the production of body fluid, tonifying kidney and calming heart, and is an adjuvant drug of the formula.

Coptidis rhizoma can be used for treating heart fire hyperactivity, vexation, insomnia, palpitation, and restlessness; tangerine peel, pericarpium Citri Reticulatae with pungent and fragrant flavor and pungent flavor moving away, warmly unblocking and bitter and dry, entering spleen and stomach meridians, has the actions of moving qi, relieving distension and drying dampness. After the traditional Chinese medicine preparation is taken, the vegetative nervous system is quickly coordinated, the blood flow is enhanced, the nerve is calmed, the restlessness is relieved, the heat and the toxicity are cleared away, the pain is relieved, the diuresis is promoted, the spleen and the stomach are invigorated, the aim of strengthening the body resistance and eliminating the evil is fulfilled, the central nervous system disorder can be adjusted, the intractable insomnia is corrected, and the whole immunity effect of the organism is enhanced.

Detailed Description

The present invention will be described in further detail with reference to examples. The embodiments are only for clear understanding of technical features, objects and effects of the present invention, and do not limit the present invention.

Clinical example 1

Weighing the cleaned and dried raw material medicaments in parts by weight (unit: g)

10 parts of ginseng, 40 parts of astragalus mongholicus, 4 parts of American ginseng, 4 parts of prepared monkshood, 20 parts of salvia miltiorrhiza, 20 parts of spina date seeds, 20 parts of schisandra chinensis, 10 parts of coptis chinensis, 6 parts of dried orange peel and 20 parts of honey-fried licorice roots.

Clinical example 2

Weighing the cleaned and dried raw material medicaments in parts by weight (unit: g)

15 parts of ginseng, 50 parts of astragalus, 5 parts of American ginseng, 5 parts of prepared monkshood, 30 parts of salvia miltiorrhiza, 30 parts of spina date seeds, 30 parts of schisandra chinensis, 15 parts of coptis chinensis, 10 parts of dried orange peel and 30 parts of honey-fried licorice root.

Clinical example 3

Weighing the cleaned and dried raw material medicaments in parts by weight (unit: g)

20 parts of ginseng, 60 parts of astragalus mongholicus, 8 parts of American ginseng, 8 parts of prepared monkshood, 40 parts of salvia miltiorrhiza, 40 parts of spina date seeds, 40 parts of schisandra chinensis, 20 parts of coptis chinensis, 12 parts of dried orange peel and 40 parts of honey-fried licorice roots.

The above preparation can be made into decoction, granule, capsule, tablet, oral liquid, pill, atomized liquid, injection, etc.

The embodiment is as follows: the pills are prepared in the clinical examples 1-3 respectively, and firstly, american ginseng of each party is crushed into fine powder and sieved; decocting the rest of Ginseng radix, radix astragali, radix Aconiti lateralis Preparata, saviae Miltiorrhizae radix, semen Ziziphi Spinosae, fructus Schisandrae chinensis, coptidis rhizoma, pericarpium Citri Tangerinae, and radix Glycyrrhizae Preparata with water twice (3 hr for the first time and 2 hr for the second time), mixing decoctions, filtering, concentrating the filtrate to obtain fluid extract with relative density of 1.20 or 1,23 or 1.25 (80 deg.C), mixing with Poria powder and radix Panacis Quinquefolii powder, drying, pulverizing, sieving, making into watered pill, and drying at low temperature. The medicine combines the drug properties in drug rehabilitation and addiction removal, mainly adopts comprehensive treatment methods of neutralization, clearing and nourishing, gives consideration to the tolerance conditions of patients with yin deficiency, qi deficiency and blood deficiency, and achieves the treatment purposes of strengthening spleen, warming kidney, clearing heart fire, dispelling cold, activating blood circulation and relieving pain. By taking the decoction, body constitution can be enhanced and resistance can be improved by strengthening body resistance and recuperating the life style of human body.

Preparation of another example of a nebulant solution:

a method of preparing a nebulant solution according to any one of the formulations one to three of the examples;

preparation of raw medicinal powder A

1. Weighing any one of the raw materials of the formula I to the formula VII;

2. the weighed raw material medicines are cut up, coarsely crushed and further nano-crushed to obtain at least partially nano-sized raw material medicines. The nano-pulverization adopts the conventional pulverization technology, for example, the plant traditional Chinese medicine is subjected to nano-pulverization by adopting a fully-closed high-speed centrifugal shearing superfine pulverizer in the embodiment, and superfine grinding is carried out for 3-10 hours to obtain nano bulk drug powder with the average particle size of below 200 nm. The totally enclosed high-speed centrifugal shearing ultrafine pulverizer adopts an advanced ultrafine grinding technology, cuts and rolls raw material particles in a short time by strong centrifugal force obtained by high-speed rotation of a main shaft and high-frequency shearing force of a plurality of ceramic grinding rings symmetrically distributed on an auxiliary shaft, and pulverizes the raw material particles into homogeneous ultrafine powder in a nanometer range. The crushing ring and the inner wall of the crushing barrel which are contacted with the medicine are both made of ceramic materials, so that the cleaning and the sterilization are easy; the crushing cylinder adopts double mechanical sealing, so that the medicine ultrafine crushing is finished in a pollution-free environment.

It is understood that other means of comminution may be used, provided that at least partial nanocrystallization is achieved to disrupt the cell walls of the plant cells.

3. Adding the nano bulk drug powder into water for extraction to obtain an extract, wherein the extraction adopts a conventional traditional Chinese medicine extraction method. The stability of plant cell wall makes the effective components difficult to extract. Generally, the bulk drug powder is taken and added with water to be boiled, and then is kept to be soaked for 1 to 3 times at the temperature of between 60 and 90 ℃ for 2 to 3 hours each time, and then the leaching solution is merged and filtered to obtain the extracting solution; the nanometer technology is utilized to process, so that the plant cell wall can be fully crushed, and the dissolution of effective components is facilitated.

4. And drying the extracting solution, wherein the freeze drying technology is adopted in the embodiment, and the dried nano raw material powder is obtained after drying and dispersing.

The nano-sized particle size of the micro traditional Chinese medicine becomes very small, the specific surface area is greatly increased, the penetration capability to tissues is also obviously increased, the viscosity is increased, and the bioavailability of the medicine is improved to the maximum extent.

B preparation of atomized liquid medicine

1. Weighing the raw material powder, adding into hot purified water, and stirring to obtain 10g water solution.

The weight of the raw material medicinal powder is 0.1g, 0.5g, 1g, 1.5g, 2g and 3g respectively.

The temperature of the water is 50 ℃,60 ℃ and 80 ℃. Dissolution experiments showed that the dissolution rate was faster in hot water at 80 ℃ and slightly slower in hot water at 50 ℃.

2. Weighing 1.3 propylene glycol and vegetable glycerin according to the weight ratio of 1:1 to form a mixed solution, namely obtaining an atomized matrix, and mixing the aqueous solution and the atomized matrix according to the weight ratio of 1:9. After being stirred evenly, atomized liquid medicine is obtained.

TABLE 1 solubility of the raw materials

The preparation of the atomized liquid medicine was completed as shown in table 1, and the solubility of the atomized liquid medicine was observed, and the atomized liquid medicine was allowed to stand for 1 day to observe the stability of the atomized liquid medicine. The results show that the content of the raw material powder by weight affects the solubility and the solution stability of the atomized liquid medicine, and that a clear and stable atomized liquid medicine cannot be obtained when the content of the raw material powder in the atomized liquid medicine exceeds 3 wt%. The dissolution temperature of the aqueous solution is increased to 80 ℃, which is beneficial to improving the solubility, but the raw material medicinal powder is separated out in the standing process, and the stability is poor.

Alternatively, the addition of a flavoring agent has improved the patient experience of medication. In the present embodiment, no flavoring agent is added.

Preparation of C atomized explosive

Injecting atomized liquid medicine into an atomized medicine bomb under an aseptic environment, wherein the amount of the injected medicine is 2mL; the injection port is then closed to form an atomized cartridge adapted to cooperate with a heated atomizing device to form a heated atomizing system.

Effect testing

And (3) testing equipment: a heated electronic atomization system. The heating power is 6W, the constant power, and the heater adopts a resistance heating atomizer. The atomized liquid capacity of a single atomized pellet is 2mL, and the concentration of the raw material powder is 0.5wt%.

Determination of therapeutic effect

The method has the following advantages: the symptoms of lustrous complexion, rhinorrhea, lacrimation, yawning, dizziness, nausea, vomit, general aching and pain, inappetence, insomnia, anxiety, fantod and the like disappear. The physical dependence, psychological dependence and tolerance generated by the opioid drugs are greatly reduced, and the physicochemical examination is normal.

Improvement: the symptoms of improved complexion, watery nasal discharge, yawning, dizziness, nausea, emesis, soreness and pain of waist and knees, inappetence, pale tongue and weak pulse are relieved, physical and chemical examination is improved, and physical dependence, psychological dependence and tolerance generated on opioid drugs are relieved.

And (4) invalidation: the symptoms are lusterless complexion, watery nasal discharge, yawning, dizziness, nausea, vomit, soreness and pain of waist and knees, inappetence, pale tongue and weak pulse. Physiological dependence on opioids, psychological dependence and resulting tolerance exist.

The pill is clinically:

66 opioid addicts were selected, 31 men and 35 women, with an average age of 36 years. Diagnostic criteria: after the abuse of the opioid is interrupted, symptoms such as euphoria, rapid pulse increase, headache, dizziness, vertigo, nausea, vomiting, loss of time and space sensation, dysphoria, irritability, even hypersomnia caused by neurasthenia, mental confusion, four-way speech, hypomnesis and the like are sometimes found;

three groups of 22 patients were subjected to clinical trials:

the first group of patients took the formulation of example 1 as pills, such as peanut rice, 1 pill per time, 3 times per day for 3 consecutive days, and were banned for severe mental diseases, severe heart, liver and kidney diseases, pregnant and lying-in women, etc.

The second group of patients took the formulation of example 2 as pills, such as peanut, 1 pill each time, 3 times a day, 3 days continuously, no treatment for severe mental diseases, no treatment for severe heart, liver and kidney diseases, and no treatment for pregnant and lying-in women.

The third group of patients took the formulation of example 3 as pills, such as peanut, 1 pill each time, 3 times a day, 3 days continuously, and prohibited for serious mental diseases, serious heart, liver and kidney diseases, pregnant and lying-in women, etc.

The treatment results are as follows:

observed after 3 days of administration, the first group of 22 patients was found to have 13 effective cases, accounting for about 59% of the total observed cases; of these, 6 improved cases account for approximately 27.2% of the total observed cases; the number of the cases is about 13.6% of the total observed cases, and the total effective rate is about 86.3%. Of the second group of 22 patients, 14 effective cases accounted for about 63.6% of the total observed cases; 6 cases are improved, about 27.2 percent of the total observed cases account for 2 ineffective cases, about 9.1 percent of the total observed cases, and the total effective rate is about 90.9 percent. Of the 22 patients in the third group, 17 effective cases were found, accounting for about 77.2% of the total observed cases; 3 cases are improved, accounting for about 13.6 percent of total observed cases; the ineffective cases account for about 9.1 percent of the total observed cases, and the total effective rate is about 90.9 percent.

Clinical experiments of the atomized liquid medicine:

75 opioid addicted patients were selected, 35 men and 40 women, with an average age of 38.5 years. Diagnostic criteria: after the abuse of the opioid is interrupted, symptoms such as euphoria, rapid pulse increase, headache, dizziness, vertigo, nausea, vomiting, loss of time and space sensation, dysphoria, irritability, even hypersomnia caused by neurasthenia, mental confusion, four-way speech, hypomnesis and the like are sometimes found;

three groups of 25 patients were subjected to clinical trials:

the first group of patients used the formulation of example 1 to prepare the nebulant liquid medicine by the above method, and the administration of the experimental group was completed by 2mL each time, once in the morning, at noon and evening, and continuously taken for 3 days, and the patients were banned for serious mental diseases, serious heart, liver and kidney diseases, pregnant and lying-in women, etc.

The second group of patients used the formulation of example 2 to prepare the nebulant liquid medicine by the above method, and the administration of the experimental group was completed by 2mL each time, once in the morning, at noon and evening, and continuously taken for 3 days, and the patients were banned for serious mental diseases, serious heart, liver and kidney diseases, pregnant and lying-in women, etc.

The third group of patients used the formulation of example 3 to prepare the nebulant liquid medicine by the above method, and the administration of the experimental group was completed by 2mL each time, once in the morning, at noon and evening, and continuously taken for 3 days, and the patients were banned for serious mental diseases, serious heart, liver and kidney diseases, pregnant and lying-in women, etc.

The treatment results are as follows:

observation after 3 days of administration revealed 16 effective patients in the first group of 25 patients, accounting for about 64% of the total observed cases; of these, 7 cases improved, accounting for approximately 28% of the total observed cases; the effective rate is about 92% and the total effective rate is about 8% in 2 cases. Of the 25 patients in the second group, 17 effective cases accounted for approximately 68% of the total observed cases; the total effective rate of the medicine is about 100 percent, and the total effective rate of the medicine accounts for about 32 percent of total observed cases after 8 cases are improved. Of the 25 patients in the third group, 16 effective cases were found, accounting for approximately 64% of the total observed cases; 8 cases are improved, accounting for about 32% of total observed cases; the effective rate is about 96% and the total effective rate is about 4% of the total observed cases.

The above-mentioned embodiments only express several embodiments of the present application, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the concept of the present application, and these are all within the scope of protection of the present application.

Claims (10)

1. A Chinese medicinal preparation for treating opioid addiction is characterized by comprising the following Chinese medicinal raw materials:

ginseng, astragalus root, american ginseng, prepared aconite root, salvia root, spiny jujube kernel, schisandra fruit, coptis root, tangerine peel and honey-fried licorice root.

2. A narcotic Chinese medicinal prescription for treating opioid addiction according to claim 1, wherein the prescription is prepared from the following raw materials in parts by weight:

10 to 20 portions of ginseng, 40 to 60 portions of astragalus root, 4 to 8 portions of American ginseng, 4 to 8 portions of prepared aconite root, 20 to 40 portions of salvia miltiorrhiza, 20 to 40 portions of spina date seed, 20 to 40 portions of schisandra chinensis, 10 to 20 portions of coptis chinensis, 6 to 12 portions of dried orange peel and 20 to 40 portions of honey-fried licorice root.

3. A narcotic-abstaining traditional Chinese medicine prescription for treating opioid addiction according to claim 1 or 2, wherein the proportion by weight is as follows:

10 or 15 or 20 parts of ginseng, 40 or 50 or 60 parts of astragalus root, 4 or 5 or 8 parts of American ginseng, 4 or 5 or 8 parts of prepared common monkshood daughter root, 20 or 30 or 40 parts of salvia miltiorrhiza, 20 or 30 or 40 parts of spina date seed, 20 or 30 or 40 parts of Chinese magnoliavine fruit, 10 or 15 or 20 parts of coptis chinensis, 6 or 10 or 12 parts of dried orange peel and 20 or 30 or 40 parts of honey-fried licorice root.

4. A narcotic Chinese medicinal formulation for use in the treatment of opioid addiction according to any of the preceding claims wherein said composition is in the form of a decoction, granules, capsules, tablets, oral liquid, spray, pills, injections or nebula.

5. A narcotic Chinese medicinal formulation for use in the treatment of opioid addiction according to claim 4, wherein said pill preparation method comprises: pulverizing radix Panacis Quinquefolii into fine powder, and sieving; decocting the rest ginseng, astragalus, prepared monkshood, salvia miltiorrhiza, spina date seed, schisandra chinensis, coptis chinensis, dried orange peel and honey-fried licorice root with water twice for 3 hours for the first time and 2 hours for the second time, merging decoction, filtering, concentrating filtrate into clear paste with the relative density of 1.20-1.25 (80 ℃), mixing with tuckahoe powder and the American ginseng powder uniformly, drying, crushing, sieving, making pills with water, and drying at low temperature to obtain the traditional Chinese medicine.

6. A narcotic abstinence traditional Chinese medicine formulation as claimed in claim 4, wherein said nebuliser formulation solution is prepared by a process comprising the steps of:

s1: weighing the raw material medicines in the formula according to the parts by weight;

s2: respectively crushing and breaking the walls of the raw material medicines to obtain raw material medicine powder with at least partial nanometer size;

s3: boiling the bulk drug powder in water, keeping warm immersion for 1-3 times at 60-90 ℃ for 2-3 hours each time, combining the leaching solution, and filtering to obtain an extracting solution;

s4: drying and dispersing the extracting solution to obtain nanoscale raw medicinal powder;

s5: dissolving the nanometer raw material powder in an atomizing matrix to obtain the atomizing agent liquid medicine.

7. The method as claimed in claim 6, wherein the ratio of the nano-sized raw medicinal powder in the atomized liquid is not more than 2%.

8. The method as claimed in claim 6, wherein the nebulizing base comprises at least an aqueous solution for dissolving the nano-sized drug powder and/or propylene glycol and/or glycerin.

9. The method as claimed in claim 8, wherein the aqueous solution is prepared by dissolving the nano-sized raw medicinal powder in hot water at a temperature higher than 50 ℃.

10. The method for preparing an atomizing agent liquid medicine according to claim 8 or 9, wherein the specific gravity of the nanoscale raw material powder in the aqueous solution is 0.5-20%.