CN115335411A - 一种TGFβR2胞外区截短分子、其与抗EGFR抗体的融合蛋白及其抗肿瘤用途 - Google Patents

一种TGFβR2胞外区截短分子、其与抗EGFR抗体的融合蛋白及其抗肿瘤用途 Download PDF

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CN115335411A
CN115335411A CN202180023395.5A CN202180023395A CN115335411A CN 115335411 A CN115335411 A CN 115335411A CN 202180023395 A CN202180023395 A CN 202180023395A CN 115335411 A CN115335411 A CN 115335411A
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tgf
antibody
fusion protein
beta
egfr
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谢良志
孙春昀
郭二红
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Sinocelltech Ltd
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Sinocelltech Ltd
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Abstract

提供了多种含有截短形式TGFβR2及其与EGFR抗体HPA8构建的融合蛋白，还提供了编码该抗体的核酸(包括重/轻链可变区)、含有该核酸的载体、药物组合物和试剂盒；还提供了制备的截短形式TGFβR2受体蛋白与靶向EGFR和其它多种肿瘤靶点抗体的融合蛋白。

Description

PCT国内申请，说明书已公开。

Claims (26)

  1. PCT国内申请，权利要求书已公开。
CN202180023395.5A 2020-04-28 2021-04-26 一种TGFβR2胞外区截短分子、其与抗EGFR抗体的融合蛋白及其抗肿瘤用途 Pending CN115335411A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202010351280 2020-04-28
CN2020103512806 2020-04-28
PCT/CN2021/089782 WO2021218883A1 (zh) 2020-04-28 2021-04-26 一种TGFβR2胞外区截短分子、其与抗EGFR抗体的融合蛋白及其抗肿瘤用途

Publications (1)

Publication Number Publication Date
CN115335411A true CN115335411A (zh) 2022-11-11

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CN202180023395.5A Pending CN115335411A (zh) 2020-04-28 2021-04-26 一种TGFβR2胞外区截短分子、其与抗EGFR抗体的融合蛋白及其抗肿瘤用途

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US (1) US20230257469A1 (zh)
EP (1) EP4144764A1 (zh)
JP (1) JP2023523981A (zh)
KR (1) KR20230003114A (zh)
CN (1) CN115335411A (zh)
AU (1) AU2021264846A1 (zh)
BR (1) BR112022021785A2 (zh)
CA (1) CA3176671A1 (zh)
MX (1) MX2022013455A (zh)
WO (1) WO2021218883A1 (zh)

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
EP1400536A1 (en) 1991-06-14 2004-03-24 Genentech Inc. Method for making humanized antibodies
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
DK2542590T4 (da) * 2010-03-05 2020-07-13 Univ Johns Hopkins Sammensætninger og fremgangsmåde til målrettede immunomodulatoriske antistof-fer og fusionproteiner
PL2970512T3 (pl) * 2013-03-12 2019-03-29 Biocon Limited Immunomodulujące białka fuzyjne i sposoby ich otrzymywania
CN105658672A (zh) * 2013-08-22 2016-06-08 阿塞勒隆制药公司 TGF-β受体II型变体及其用途
BR112016021717A2 (pt) * 2014-03-21 2018-07-10 Abbvie Inc anticorpos anti-egfr e conjugados anticorpo-fármaco
KR102635723B1 (ko) * 2017-05-04 2024-02-08 악셀레론 파마 인코포레이티드 Tgf-베타 수용체 유형 ii 융합 단백질 및 이의 용도
CA3061791A1 (en) * 2017-05-12 2019-10-29 Jiangsu Hengrui Medicine Co., Ltd. Fusion protein containing tgf-.beta. receptor and medicinal uses thereof
WO2019114793A1 (zh) * 2017-12-13 2019-06-20 凯惠科技发展(上海)有限公司 一种egfr抗体及其制备方法和应用
CN108250297B (zh) * 2018-01-23 2021-07-23 上海生物制品研究所有限责任公司 抗egfr抗体、其制法及其应用
CN110467676B (zh) * 2019-09-24 2020-06-05 武汉奥科博泰生物科技有限公司 特异性结合egfr的单克隆抗体及其抗癌用途

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WO2021218883A1 (zh) 2021-11-04
JP2023523981A (ja) 2023-06-08
BR112022021785A2 (pt) 2022-12-06
KR20230003114A (ko) 2023-01-05
US20230257469A1 (en) 2023-08-17
EP4144764A1 (en) 2023-03-08
CA3176671A1 (en) 2021-11-04
AU2021264846A1 (en) 2022-12-08
MX2022013455A (es) 2022-11-16

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