CN115315530A - 使用特定基因中cpg甲基化改变以诊断膀胱癌的组合物及其用途 - Google Patents

使用特定基因中cpg甲基化改变以诊断膀胱癌的组合物及其用途 Download PDF

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CN115315530A
CN115315530A CN202180023436.0A CN202180023436A CN115315530A CN 115315530 A CN115315530 A CN 115315530A CN 202180023436 A CN202180023436 A CN 202180023436A CN 115315530 A CN115315530 A CN 115315530A
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methylation
bladder cancer
gene
march11
iffo1
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赵相来
文永镐
韩振日
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Gencurix Inc
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Gencurix Inc
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
CN202180023436.0A 2020-01-28 2021-01-28 使用特定基因中cpg甲基化改变以诊断膀胱癌的组合物及其用途 Pending CN115315530A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2020-0010053 2020-01-28
KR1020200010053A KR102637032B1 (ko) 2020-01-28 2020-01-28 특정 유전자의 CpG 메틸화 변화를 이용한 방광암 진단용 조성물 및 이의 용도
PCT/KR2021/001154 WO2021154009A1 (ko) 2020-01-28 2021-01-28 특정 유전자의 CpG 메틸화 변화를 이용한 방광암 진단용 조성물 및 이의 용도

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CN115315530A true CN115315530A (zh) 2022-11-08

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US (1) US20230084248A1 (enExample)
EP (1) EP4098755A4 (enExample)
JP (1) JP7828613B2 (enExample)
KR (1) KR102637032B1 (enExample)
CN (1) CN115315530A (enExample)
WO (1) WO2021154009A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118147311A (zh) * 2024-05-13 2024-06-07 北京橡鑫生物科技有限公司 尿路上皮癌甲基化标志物试剂盒

Families Citing this family (3)

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Publication number Priority date Publication date Assignee Title
WO2023083348A1 (zh) * 2021-11-15 2023-05-19 武汉艾米森生命科技有限公司 用于食管癌诊断的甲基化检测试剂及试剂盒
CN116168761B (zh) * 2023-04-18 2023-06-30 珠海圣美生物诊断技术有限公司 核酸序列特征区域确定方法、装置、电子设备及存储介质
CN118230812A (zh) * 2023-12-15 2024-06-21 王姝瑶 一种精确筛查的基因检测方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120101023A1 (en) * 2009-04-20 2012-04-26 Erasmus University Medical Center Rotterdam Method of diagnosing bladder cancer
WO2016108403A1 (ko) * 2014-12-30 2016-07-07 충북대학교 산학협력단 방광암 예후 진단 마커로서 rsph9의 용도
US20180148776A1 (en) * 2015-02-24 2018-05-31 Zymo Research Corporation Assays to determine dna methylation and dna methylation markers of cancer
CN108350504A (zh) * 2015-06-24 2018-07-31 Ucl商业有限公司 膀胱癌的诊断方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1370685A2 (en) 2000-04-06 2003-12-17 Epigenomics AG Diagnosis of diseases associated with dna repair
EP1961827A3 (en) * 2004-07-18 2008-09-17 Epigenomics AG Epigenetic methods and nucleic acids for the detection of breast cell proliferative disorders
ES2534139T3 (es) * 2004-12-02 2015-04-17 Epigenomics Ag Métodos y ácidos nucleicos para el análisis de la expresión génica asociada con el pronóstico de trastornos proliferativos de células de próstata
KR101708544B1 (ko) * 2005-04-15 2017-02-20 에피제노믹스 아게 세포 증식 질환을 분석하기 위한 방법 및 핵산
CA2683854A1 (en) * 2007-04-11 2008-10-30 Manel Esteller Epigenetic biomarkers for early detection, therapeutic effectiveness, and relapse monitoring of cancer
US8399193B2 (en) * 2007-08-30 2013-03-19 City Of Hope DNA methylation biomarkers for lung cancer
EP2217728A4 (en) * 2007-11-30 2011-01-05 Genomictree Inc KIT AND DIAGNOSTIC CHIP FOR BLADDER CANCER USING A SPECIFIC METHYLATION MARKER GENE FOR BLADDER CANCER
MX2011000655A (es) * 2008-07-18 2011-03-21 Oragenics Inc Composiciones para la deteccion y tratamiento de cancer colorrectal.
EP2233590A1 (en) * 2009-01-28 2010-09-29 AIT Austrian Institute of Technology GmbH Methylation assay
WO2012167145A2 (en) * 2011-06-01 2012-12-06 University Of Southern California Genome-scale analysis of aberrant dna methylation in colorectal cancer
US9096905B2 (en) * 2012-02-23 2015-08-04 Medical Diagnostic Laboratories, Llc Detecting DNA methylation of BCL2, CDKN2A and NID2 genes to predict bladder cancer in humans
CA3023335A1 (en) * 2016-05-04 2017-11-30 Queen's University At Kingston Cell-free detection of methylated tumour dna
US11207340B2 (en) * 2017-05-26 2021-12-28 The Chinese University Of Hong Kong Tumor suppressor TET1 and uses thereof
WO2019195941A1 (en) * 2018-04-13 2019-10-17 London Health Sciences Centre Research Inc. Dna methylation assays and methods
SG11202012585YA (en) * 2018-06-22 2021-01-28 Bluestar Genomics Inc Hydroxymethylation analysis of cell-free nucleic acid samples for assigning tissue of origin, and related methods of use
US10249912B1 (en) 2018-07-18 2019-04-02 Lg Chem, Ltd. Electrical control system

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120101023A1 (en) * 2009-04-20 2012-04-26 Erasmus University Medical Center Rotterdam Method of diagnosing bladder cancer
WO2016108403A1 (ko) * 2014-12-30 2016-07-07 충북대학교 산학협력단 방광암 예후 진단 마커로서 rsph9의 용도
US20180148776A1 (en) * 2015-02-24 2018-05-31 Zymo Research Corporation Assays to determine dna methylation and dna methylation markers of cancer
CN108350504A (zh) * 2015-06-24 2018-07-31 Ucl商业有限公司 膀胱癌的诊断方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BRENNA ANE: "Identification of novel epigenetic masterkeys in cancer - with potential diagnostic value", 《DUO RESEARCH ARCHIVE》, 31 May 2014 (2014-05-31) *
HYUNG-YOON YOON等: "RSPH9 methylation pattern as a prognostic indicator in patients with non-muscle invasive bladder cancer", 《ONCOL REP》, vol. 35, no. 2, 11 November 2015 (2015-11-11), pages 1195 - 203, XP055832508, DOI: 10.3892/or.2015.4409 *
MIHAELA CAMPAN等: "Genome-Scale Screen for DNA Methylation-Based Detection Markers for Ovarian Cancer", 《PLOS ONE》, vol. 6, no. 12, 7 December 2011 (2011-12-07), pages 28141 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118147311A (zh) * 2024-05-13 2024-06-07 北京橡鑫生物科技有限公司 尿路上皮癌甲基化标志物试剂盒

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US20230084248A1 (en) 2023-03-16
KR20210096509A (ko) 2021-08-05
EP4098755A1 (en) 2022-12-07
WO2021154009A1 (ko) 2021-08-05
JP2023513039A (ja) 2023-03-30
EP4098755A4 (en) 2024-06-26
JP7828613B2 (ja) 2026-03-12

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