CN115300407A

CN115300407A - Anti-aging repair essence and preparation method thereof

Info

Publication number: CN115300407A
Application number: CN202211137438.5A
Authority: CN
Inventors: 肖亚杰; 邹六均; 肖龙兴
Original assignee: Guangzhou La Doris Cosmetics Co ltd
Current assignee: Guangzhou La Doris Cosmetics Co ltd
Priority date: 2022-09-19
Filing date: 2022-09-19
Publication date: 2022-11-08

Abstract

The application relates to the field of skin care essence, in particular to anti-aging repair essence and a preparation method thereof. An anti-aging repair essence comprises the following raw materials in percentage by mass: 7-10% of humectant, 0-0.2% of thickener, 0.1-0.4% of tetrahydro-methyl pyrimidine carboxylic acid, 0.1-0.3% of carnosine, 0.3-0.6% of maltose, 0.1-0.3% of Taikulan violet leaf extract, 0.05-0.15% of apple fiber, 0-0.002% of acetyl hexapeptide-8, 0-0.5% of supplementary plant extract and water to 100%; the preparation method comprises the following steps: mixing and stirring the humectant, the thickener and water uniformly; adjusting the temperature to 75-88 ℃, and homogenizing and dispersing until the temperature is uniform; cooling to 38-50 deg.C, adding the rest materials, and stirring; discharging to obtain a finished product. The method has the advantage of gently playing a good anti-aging repair effect.

Description

Anti-aging repair essence and preparation method thereof

Technical Field

The application relates to the field of skin care essence, in particular to anti-aging repair essence and a preparation method thereof.

Background

The change of skin is most obvious in the aging process of human body. Generally, after 25 years of age, women begin to have a downward tendency to the skin; after age 30, the skin is aged early. The forms of skin aging are mainly natural aging and photoaging aging. Photoaging aging is mainly skin aging caused by accumulation of ultraviolet damage, and is a result of combined action of natural aging and ultraviolet irradiation, and is limited to the exposed part of the skin. The main characteristics are that the skin is rough and lusterless, the skin becomes thick and deep steadily, the pigmentation is deepened, the skin microcirculation is worsened, the elastic tissue is deformed, the epidermis shows the phenomena of the reduction of the cleaning power, the synthetic capability of collagen and elastin and the immunity, the thinning of the dermis thickness, the easy occurrence of allergic inflammation and the like.

Skin aging is a progressive physiological process and is also the result of the combined action of various factors such as genetics, environment, psychology and the like. With the improvement of living standard of people, the functional requirements on skin care products are higher and higher. At present, most of anti-aging skin care products on the market use raw materials such as essence, spice, preservative, surfactant and the like, and the raw materials are common skin allergens and are not mild enough. Therefore, improvement is yet to be achieved.

Disclosure of Invention

In order to achieve good anti-aging and repairing effects mildly, the application provides anti-aging and repairing essence and a preparation method thereof.

In a first aspect, the application provides an anti-aging repair essence, which adopts the following technical scheme:

an anti-aging repair essence comprises the following raw materials in percentage by mass: 7-10% of humectant, 0-0.2% of thickener, 0.1-0.4% of tetrahydro-methyl pyrimidine carboxylic acid, 0.1-0.3% of carnosine, 0.3-0.6% of maltose, 0.1-0.3% of Taikulan violet leaf extract, 0.05-0.15% of apple fiber, 0-0.002% of acetyl hexapeptide-8, 0-0.5% of supplementary plant extract and water to 100%.

The essence provided by the application does not use a surfactant, essence and a preservative, but uses new active substances such as micromolecular polypeptides and plant extracts, so that the prepared essence is mild and safe, has good skin-friendly performance, accords with a currently advocated skin care mode, and is suitable for popularization in the industry.

Carnosine and acetyl hexapeptide-8 belong to small molecular polypeptides and have good repairing effects. When the two are mixed according to a specific proportion, the essence acts on the surface of the skin, and can more quickly permeate into the skin, so that the effects of removing free radicals and improving the growth of neurotransmitters are achieved.

The skin is easily induced to generate aldehyde substances after being irradiated by ultraviolet rays, and the substances resist the digestion of elastase by modifying elastin, so that the damage of lipid peroxidation to the skin is improved, and the aging is accelerated.

By adopting the technical scheme, under the co-cooperation of the tetrahydro-methyl pyrimidine carboxylic acid, the carnosine and the folium agaves variegatae extract, the generation of active carbonyl substances is further reduced, so that the probability of the combination of the active carbonyl substances and protein is reduced, and the generation of oxidation products is further reduced. The formation of oxidation products can carbonylate proteins in the body, and the accumulation in the body can cause skin roughness, affect elasticity, and thus, expose aging. The oxidation products are reduced to reduce protein carbonylation caused by ultraviolet irradiation, thereby achieving the anti-aging effect.

Secondly, the combination of the three can also improve the toxic effect of carnosine on inhibiting protein carbonylation, reduce the functional damage of biological molecules, further reduce lipid peroxidation, keep good skin elasticity and weaken the influence of ultraviolet rays on the skin.

In addition, the inventor finds that the combination of the three can strongly inhibit the secretion and release of some cytokines in the inflammatory reaction process, thereby reducing the severity of facial inflammation of the user.

Preferably, the anti-aging repair essence comprises the following raw materials in percentage by mass: 7-10% humectant, 0-0.2% thickener, 0.1-0.4% tetrahydro-methyl-pyrimidinecarboxylic acid, 0.1-0.3% carnosine, 0.3-0.6% maltose, 0.1-0.3% agave tongue leaf extract, 0.05-0.15% apple fiber, 0-0.002% acetyl hexapeptide-8, 0-0.03% centella asiatica extract, 0-0.03% polygonum cuspidatum root extract, 0-0.03% scutellaria baicalensis root extract, 0-0.03% tea leaf extract, 0-0.03% glycyrrhiza glabra root extract, 0-0.03% chamomile chrysanthemum extract, 0-0.03% rosemary leaf extract, 0-0.1% ascochyta extract, 0-0.03% inositol, 0-0.01% elastin, 0-0.01% soluble collagen, 0-0.01% hydroxyproline, 0-0.01% fibronectin, and water to 100%.

Preferably, the weight ratio of the tetrahydromethylpyrimidine carboxylic acid to the carnosine to the agave leaf extract is 1: (0.9-1.1): (0.4-0.6).

By adopting the technical scheme, the use proportion of the tetrahydro-methyl pyrimidine carboxylic acid, the carnosine and the too deficient agave leaf extract is further limited, so that the tetrahydro-methyl pyrimidine carboxylic acid, the carnosine and the too deficient agave leaf extract have more sufficient matching effect, and the anti-aging effect is further more remarkable.

Preferably, the thickener may be hydroxyethyl cellulose, hydroxymethyl cellulose, carbomer.

Preferably, the humectant is one or more of glycerin, sodium hyaluronate, sodium polyglutamate, 1, 2-hexanediol, butanediol, propylene glycol, 1, 3-propylene glycol, caprylyl hydroximic acid and ethylhexyl glycerin.

Preferably, when the moisturizer comprises sodium hyaluronate and sodium polyglutamate, the mass ratio of the sodium hyaluronate to the sodium polyglutamate to the carnosine is (0.4-0.6) to (0.4-0.6): 1.

by adopting the technical scheme, the moisturizing agent of a specific kind is selected to be matched with the carnosine in a specific proportion, and the moisturizing agent with different molecular sizes acts on the skin, so that the absorption and locking of the skin to moisture are increased, and a better moisturizing effect is achieved.

The good basic moisture retention enables the skin to be in a moist and tender state for a long time, the skin is not sensitive easily, the skin is in a healthy state, and allergy caused by external conditions is not easy to cause, so that the skin has a strong anti-aging and repairing effect.

Preferably, when the humectant comprises propylene glycol, caprylyl hydroximic acid and ethylhexyl glycerin, the mass ratio of the propylene glycol, the caprylyl hydroximic acid and the ethylhexyl glycerin is (25-35): (1-3): 1.

the product uses plant extracts, and the shelf life of the product is short if no preservative is added; if preservatives are used, this can make the product unable to fit the masses of sensitive muscles.

By adopting the technical scheme, the cooperation of the propylene glycol, the caprylyl hydroximic acid and the ethylhexyl glycerin not only can play a moisturizing effect, but also can cooperatively play a mild anticorrosion effect. Not only prolongs the storage time of the product, but also ensures the mildness of the product.

Preferably, the mass ratio of the maltose to the agave americana leaf extract is (4-6): 1.

the maltose can improve the adhesiveness of the whole essence on the skin, thereby prolonging the time of the essence acting on the skin and fully exerting the effects of various substances. However, maltose is directly added into the essence, and the prepared essence gives sticky skin feeling to users.

By adopting the technical scheme, under the common cooperation of the maltose and the too deficient agave leaf extract, the sticky skin feeling is effectively relieved, the good attachment to the face is realized, and the refreshing, thin and transparent good skin feeling is brought to a user.

Preferably, the plant extracts include, but are not limited to, centella asiatica extract, scutellaria baicalensis root extract, ascochyta sativa extract, and rosemary leaf extract.

The plant extract is green and safe, and plant extracts with various functions can be added into the essence system according to the actual sale condition, so that the essence is endowed with more effects, and the competitiveness of the product in actual sale is improved.

In a second aspect, the application provides a preparation method of the anti-aging repair essence, which adopts the following technical scheme: the preparation method of the anti-aging repair essence comprises the following steps:

mixing and stirring the humectant, the thickener and water uniformly;

adjusting the temperature to 75-88 ℃, and homogenizing and dispersing until the temperature is uniform;

cooling to 38-50 deg.C, adding the rest materials, and stirring;

discharging to obtain a finished product.

By adopting the technical scheme, various raw materials are orderly added and mixed at a specific temperature, so that the raw materials can be fully matched and reacted, and the fine and uniform essence is prepared.

Preferably, after the residual raw materials are added and uniformly stirred after the temperature is reduced, standing until no bubbles exist on the surface; then the mixture is filtered by 400 to 500 meshes and discharged.

By adopting the technical scheme, after standing without bubbles, the essence is filtered by using the 400-500 mesh filter screen, so that impurities in the essence are reduced, and the essence can provide a finer skin feel for a user after being applied to the face.

In summary, the present application has the following beneficial effects:

1. because the application does not use a surfactant, essence and a preservative, but uses new active substances such as micromolecular polypeptides and plant extracts, the prepared essence is mild and safe, has good skin-friendly performance, accords with the currently recommended skin care mode, and is suitable for popularization in the industry.

2. Under the combined cooperation of the tetrahydro-methyl pyrimidine carboxylic acid, the carnosine and the extract of the agave leaf, the generation of active carbonyl substances is further reduced, so that the probability of the active carbonyl substances combining with protein is reduced, and the generation of oxidation products is reduced; can also improve the toxic effect of carnosine in inhibiting protein carbonylation, reduce the functional damage of biological molecules and further reduce lipid peroxidation; the skin elasticity is kept good, the influence of ultraviolet rays on the skin is weakened, and the anti-aging effect is achieved.

3. The moisturizing agent of a specific kind is selected to be matched with the carnosine in a specific proportion, and the moisturizing agent with different molecular sizes acts on the skin, so that the absorption and locking of the skin to moisture are increased, and a better moisturizing effect is achieved.

Detailed Description

The present application will be described in further detail with reference to examples.

The plant extracts used in the following examples and comparative examples were commercially available dry products, after purchase, the dust was washed with water and dried, and then put into use, and the remaining raw materials were commercially available products.

Examples

Example 1

The anti-aging repair essence comprises the following raw materials: humectant, thickener, tetrahydro-methyl pyrimidine carboxylic acid, carnosine, maltose, folium agaves variegatae (AGAVETEQUILANA) extract, fructus Mali Pumilae (PYRUSMALUS) fiber, acetyl hexapeptide-8, and water.

Wherein the humectant comprises glycerin; the thickener comprises hydroxymethyl cellulose. The amounts of the various raw materials are specified in table 1.

The embodiment of the application also provides a preparation method of the anti-aging repair essence, which comprises the following steps:

step 1): adding the humectant, the thickener and water into an emulsifying pot, mixing at 30r/min, and stirring to be uniform.

Step 2): then adjusting the temperature to 88 ℃, starting homogenization, adjusting to 3000r/min, and homogenizing for 5min until the mixture is dispersed uniformly.

And step 3): cooling to 50 deg.C, adding the rest raw materials at 30r/min, and stirring.

Step 4): after stirring uniformly, stopping stirring, and standing at room temperature until no bubbles exist on the surface.

And step 5): then filtering the mixture by a 500-mesh filter screen, and discharging the material to obtain a finished product.

Example 2

An anti-aging repair essence, which is different from the essence in example 1,

a supplementary plant extract is also added, wherein the supplementary plant extract is a centella asiatica extract.

The humectant comprises propylene glycol; the thickener comprises carbomer.

The amount of each raw material used is different, and the details are shown in table 1.

The preparation method of the anti-aging repair essence is different from the embodiment 1 in that,

in step 2), the temperature is adjusted to 75 ℃.

In step 3), the temperature is adjusted to 38 ℃.

Filtering by a 400-mesh filter screen in the step 5).

Example 3

An anti-aging and repairing essence is different from that in example 1 in that it further comprises centella asiatica (centella asiatica) extract, polygonum cuspidatum (polygonum cuspidatum) root extract, scutellaria baicalensis (scutelaria aicalensis) root extract, camellia sinensis (camelliaensis) leaf extract, glycyrrhiza glabra (glycyrrhiza glabra) root extract, chamomilla (chamomilla recutita) flower extract, rosemary (rosmarinus officinalis) leaf extract, streptoverticillium officinale (cystoisolium) extract, inositol, elastin, soluble collagen, hydroxyproline, and fibronectin.

Wherein the humectant comprises glycerol, sodium hyaluronate, sodium polyglutamate, 1, 2-hexanediol, butanediol, propylene glycol, 1, 3-propylene glycol, caprylyl hydroximic acid, and ethylhexyl glycerol.

The mass ratio of sodium hyaluronate to sodium polyglutamate to carnosine is 0.5.

in step 2) the temperature was adjusted to 85 ℃.

In step 3) the temperature is adjusted to 45 ℃.

Example 4

An anti-aging repair essence is different from the essence in example 3 in the use amount of various raw materials, and is specifically shown in table 1.

TABLE 1

Example 5

An anti-aging repair essence is different from that in example 4 in that the mass ratio of the tetrahydro-methyl pyrimidine carboxylic acid to the carnosine to the agave leaf extract is 1:1.1:0.4, namely the usage amount of the tetrahydromethylpyrimidine carboxylic acid is 0.2kg, the usage amount of the carnosine is 0.22kg, and the usage amount of the agave leaf extract is 0.08kg.

Example 6

An anti-aging repair essence is different from that in example 4 in that the mass ratio of the tetrahydro-methyl pyrimidine carboxylic acid to the carnosine to the agave leaf extract is 1:0.9:0.6, namely the usage amount of the tetrahydromethylpyrimidine carboxylic acid is 0.2kg, the usage amount of the carnosine is 0.18kg, and the usage amount of the agave leaf extract is 0.12kg.

Example 7

An anti-aging repair essence is different from that in example 4 in that the mass ratio of sodium hyaluronate, sodium polyglutamate to carnosine is 0.1. Namely, the usage amount of the sodium hyaluronate is 0.0194kg, the usage amount of the sodium polyglutamate is 0.1746kg, and the usage amount of the carnosine is 0.194kg.

Example 8

An anti-aging repair essence is different from that in example 4 in that the mass ratio of maltose to the extract of the folium agaves variegatae is 6:1. that is, maltose is used in an amount of 0.6kg, and folium agaves Variegatae extract is used in an amount of 0.1kg.

Example 9

An anti-aging repair essence is different from that in example 4 in that the mass ratio of propylene glycol, caprylyl hydroximic acid and ethylhexyl glycerin is 25:3:1. that is, propylene glycol was used in an amount of 0.45kg, caprylyl hydroxamic acid was used in an amount of 0.054kg, and ethylhexylglycerin was used in an amount of 0.018kg.

Example 10

The anti-aging repair essence is different from the essence in example 4 in that the mass ratio of propylene glycol, caprylyl hydroximic acid and ethylhexyl glycerol is 35:1:1. that is, propylene glycol was used in an amount of 0.63kg, caprylhydroxamic acid was used in an amount of 0.018kg, and ethylhexylglycerin was used in an amount of 0.018kg.

The specific amounts used for examples 5 to 10 are summarized in Table 2.

TABLE 2

Comparative example

Comparative example 1

An anti-aging repair essence is different from that in example 4 in that tetrahydromethylpyrimidine carboxylic acid is replaced by equal mass of an extract of leaves of agave americana.

Comparative example 2

An anti-aging repair essence, which is different from that in example 4 in that carnosine is replaced by acetyl hexapeptide-8 with equal mass.

Comparative example 3

An anti-aging repair essence, which is different from that in example 4 in that the leaves of the agave americana are replaced by centella asiatica extract of equal mass.

Comparative example 4

An anti-aging and repairing essence is different from the essence in example 4 in that the consumption of the tetrahydro-methyl pyrimidine carboxylic acid is 0.6kg, the consumption of the carnosine is 0.05kg, the consumption of the Taikui folium agaves Variegatae extract is 0.05kg, and the consumption of the water is 88.951kg.

Comparative example 5

An anti-aging repair essence is different from that in example 4 in that propylene glycol, caprylyl hydroximic acid and ethylhexyl glycerol are replaced by phenoxyethanol with equal mass.

Performance test subjects: 30 volunteers aged 25-35 were selected, one group consisting of two volunteers, and 15 groups were divided. Volunteers were stood outdoors at 9 am and 6 pm for 15 minutes at night, with outdoor uv index of 2-3.

During the test period, the volunteers applied 2ml of the corresponding samples to the face uniformly after basic cleansing and spraying of toner every morning and evening. No additional cosmetic, skin care, was used during the test.

Detecting a sample: examples 1 to 10, comparative examples 1 to 5.

Detection conditions are as follows: the detection is carried out in a room with the temperature of 25 ℃ and the relative humidity of 75-85 percent.

1. Moisture retention performance: the test subjects were tested before and 30 days after use. The forehead of the detected object is measured by using a skin moisture meter.

Change rate (%) = (30 days used-before use)/100% before use

2. Anti-aging performance: the test subjects were tested before and 30 days after use. And measuring the grain of the test object by using a skin elasticity detector.

Rate of change (%) = (30 days used-before use)/100% before use

3. And (3) apparent observation: and observing the face condition of the detected object by naked eyes after the detected object is used for 30 days, and recording whether the face is moist and smooth, whether fine lines are obvious, whether the face has discomfort phenomena such as redness and swelling and the like.

4. And (3) corrosion prevention detection: the products of examples 1 to 10 and comparative examples 1 to 5 were filled in 50ml brown transparent bottles, the caps were opened, and the bottles were placed at 40 ℃ and 75 to 80% relative humidity to observe whether they were rancid or not on day 30.

The results of the above 1-4 tests are shown in Table 3.

TABLE 3-1

TABLE 3-2

User feedback, namely, the examples 1-7, the examples 9-10 and the comparative examples 1-5 are fresh and thin after the face is put on; the essence of example 8 had a sticky feel on the face.

As can be seen from the comparison of the test data of examples 1-4 and comparative examples 1-3 in Table 3, the products of examples 1-4 can effectively increase the water content of the face after being applied to the face for a period of time, so that the face has good elasticity and is moist and smooth. Shows that under the combined action of the tetrahydro-methyl pyrimidine carboxylic acid, the carnosine and the extract of the leaves of the agave, the active carbonyl substances can be effectively reduced, and the skin elasticity can be improved through a series of reactions. And the combination of the three is beneficial to improving the skin quality, so that the skin is healthier, the inflammation is reduced, and the nutrient substances can be better absorbed.

According to the comparison of the detection data of the examples 4-6 and the comparative example 4 in the table 3, it can be seen that the combination of the three components is not enough, and the essence prepared by the three components needs to be used together at a specific ratio, so that the prepared essence can exert corresponding good effects.

As can be seen from comparison of the test data of examples 4 and 9-10 and comparative example 5 in Table 3, the product of comparative example 5 contains the core compound of the present application, and therefore, can exert good anti-aging and moisturizing effects. However, the product of comparative example 5, when applied to the face, causes a greater degree of discomfort and cannot be applied to sensitive people.

As can be seen from comparison of the test data of example 4 and example 7 in table 3, sodium hyaluronate, sodium polyglutamate and carnosine can more fully exert the effect of mixing carnosine with other substances at a specific ratio (example 4), thereby having better anti-aging and moisturizing effects.

As can be seen from comparison of the test data of example 4 and example 8 in Table 3, maltose and the extract of leaves of agave podophylla are within a certain range, and can alleviate the sticky feeling brought by maltose. When the proportion of the two components exceeds a certain range, the essence can be sticky to the face again, and the face cannot absorb the nutrient components well.

The specific embodiments are only for explaining the present application and are not limiting to the present application, and those skilled in the art can make modifications to the embodiments without inventive contribution as required after reading the present specification, but all the embodiments are protected by patent law within the scope of the claims of the present application.

Claims

1. The anti-aging repair essence is characterized by comprising the following raw materials in percentage by mass: 7-10% of humectant, 0-0.2% of thickener, 0.1-0.4% of tetrahydro-methyl pyrimidine carboxylic acid, 0.1-0.3% of carnosine, 0.3-0.6% of maltose, 0.1-0.3% of Taikulan magnolia leaf extract, 0.05-0.15% of apple fiber, 0-0.002% of acetyl hexapeptide-8, 0-0.5% of supplementary plant extract and water to 100%.

2. The anti-aging repair essence according to claim 1, which is characterized in that: the weight ratio of the tetrahydromethylpyrimidine carboxylic acid to the carnosine to the agave leaf extract is 1: (0.9-1.1): (0.4-0.6).

3. The anti-aging repair essence according to claim 1, which is characterized in that: the humectant is one or more of glycerol, sodium hyaluronate, sodium polyglutamate, 1, 2-hexanediol, butanediol, propylene glycol, 1, 3-propylene glycol, caprylyl hydroximic acid and ethylhexyl glycerol.

4. The anti-aging repair essence according to claim 3, wherein: when the humectant contains sodium hyaluronate and sodium polyglutamate, the mass ratio of the sodium hyaluronate to the sodium polyglutamate to the carnosine is (0.4-0.6) to (0.4-0.6): 1.

5. the anti-aging repair essence according to claim 3 or 4, wherein: when the humectant comprises propylene glycol, caprylyl hydroximic acid and ethylhexyl glycerin, the mass ratio of the propylene glycol, the caprylyl hydroximic acid and the ethylhexyl glycerin is (25-35): (1-3): 1.

6. the anti-aging repair essence according to claim 1, which is characterized in that: the mass ratio of the maltose to the folium agaves variegatae extract is (4-6): 1.

7. the preparation method of the anti-aging repair essence according to any one of claims 1 to 6, which comprises the following steps:

mixing and stirring the humectant, the thickener and water uniformly;

adjusting the temperature to 75-88 ℃, and homogenizing and dispersing until uniform;

cooling to 38-50 deg.C, adding the rest materials, and stirring;

discharging to obtain a finished product.

8. The method for preparing the anti-aging repair essence according to claim 7, wherein the anti-aging repair essence comprises the following steps: after the residual raw materials are added and uniformly stirred after the temperature is reduced, standing until no bubbles exist on the surface; then the mixture is filtered by 400 to 500 meshes and discharged.