CN115300401A

CN115300401A - Silver ion-containing itching-relieving, skin-tendering, skin-protecting, moisturizing and antibacterial compound and application thereof

Info

Publication number: CN115300401A
Application number: CN202111230797.0A
Authority: CN
Inventors: 江桂忠; 戴丽芳; 江珊
Original assignee: Guangdong Zhenghuiyuan Industrial Co ltd
Current assignee: Guangdong Zhenghuiyuan Industrial Co ltd
Priority date: 2021-10-22
Filing date: 2021-10-22
Publication date: 2022-11-08

Abstract

The application relates to the technical field of antibacterial washing products, in particular to a silver ion-containing antibacterial compound for relieving itching, tendering skin, protecting skin and moisturizing and an application thereof. The raw materials for preparing the silver-containing plant extract comprise plant extracts and silver ions; the raw materials for preparing the chitosan-chlorhexidine acetate copolymer comprise chitosan and/or chlorhexidine acetate; the plant extract comprises a component A and/or a component B, wherein the component A comprises a callicarpa nudiflora extract, a honeysuckle extract, a sophora flavescens extract, a phellodendron extract and a wormwood extract; the component B comprises a cortex dictamni extract, a fructus kochiae extract, a herba schizonepetae extract and a stiff silkworm extract; preferably, the preparation raw materials of the compound also comprise humectants such as glycerol, camellia seed oil, vitamins, nicotinamide, hyaluronic acid and the like. The compound of the invention adopts proper amount of chitosan, silver ions and/or chlorhexidine acetate, and fully plays roles of ensuring antibacterial itching relieving, skin tendering, skin caring and moisturizing by regulating and controlling the content of the chitosan, the silver ions and/or the chlorhexidine acetate.

Description

Silver ion-containing itching-relieving, skin-tendering, skin-protecting, moisturizing and antibacterial compound and application thereof

Technical Field

The application relates to the technical field of antibacterial washing products, in particular to a silver ion-containing antibacterial compound for relieving itching, tendering skin, protecting skin and moisturizing and an application thereof.

Background

The quality of life of people is obviously improved, on the one hand, the requirement of abundant people on human health care is higher and higher, the plant extracts from natural sources have rich biological functions, such as emulsification, bacteriostasis, deodorization, hemostasis, anti-inflammation, prevention of diseases such as dental caries, oral ulcer and the like, the plant active extracts with the functions are reasonably and effectively used in a composite way, and unexpected effects can be achieved. Because the plant active molecules have strong synergistic effect, after two or more than two extracts are mixed according to a certain proportion, the biological characteristics of the respective active molecules can be fully exerted to the utmost extent, and the effect which cannot be compared with the effect of using one extract singly is achieved, namely the additive effect.

The excellent performances of the chitosan such as biological functionality and compatibility, blood compatibility, safety, microbial degradability and the like are widely concerned by various industries, and the chitosan has wide application in various fields such as medicine, food, chemical engineering, cosmetics, water treatment, metal extraction and recovery, biochemistry and biomedical engineering and the like, is convenient to use, can quickly sterilize, and has wide application prospect and huge market value. The silver ions can adsorb microorganisms, so that microbial cells are damaged, the antibacterial and bactericidal effects are achieved, and the antibacterial silver ion can be used in antibacterial products. Chinese patent CN102552964B discloses a technical scheme for jointly using antibacterial ions and chitosan, however, additives such as zinc acetate, glycerol, urea and the like are adopted, plant extracts are not contained, the using effect is not mild enough, and although the antibacterial effect can be achieved, the granulation promoting and itching relieving effects cannot be promoted, and the healing of wounds and the like cannot be fundamentally promoted. Chinese patent CN101721733A also discloses a medical chitosan antibacterial dressing. Chitosan and antibacterial particles are widely applied to antibacterial materials, particularly various fiber fabrics, but the problem of weak antibacterial ability, poor effect and the like of chitosan in some washing and caring articles is also existed, so that the chitosan is ignored by people.

Disclosure of Invention

In order to solve the technical problems, the invention provides a compound containing silver ions, which has the effects of relieving itching, tendering skin, protecting skin, moisturizing and resisting bacteria, and is prepared from plant extracts and silver ions; the raw materials for preparing the chitosan-chlorhexidine acetate copolymer comprise chitosan and/or chlorhexidine acetate; the plant extract comprises a component A and/or a component B, wherein the component A comprises a nakedflower beautyberry leaf extract, a honeysuckle extract, a radix sophorae flavescentis extract, a golden cypress extract and a wormwood extract; the component B comprises a cortex dictamni extract, a fructus kochiae extract, a herba schizonepetae extract and a stiff silkworm extract; preferably, the raw materials for preparing the compound also comprise a humectant component.

As a preferred technical scheme of the invention, the component A also comprises one or more of angelica sinensis extract, isatis root extract, dandelion extract, plantain herb extract, motherwort extract, fructus cnidii extract, grapefruit extract, chinese aralia extract and bock greenbrier rhizome extract; preferably, the humectant component comprises one or more of glycerin, camellia oil, niacinamide (NMN, NAD), vitamins, and hyaluronic acid.

As a preferable technical scheme of the invention, the weight ratio of the chitosan to the plant extract is 1: (4-10).

As a preferable technical scheme of the invention, the content of the silver ions in the composition is 10-1500 ppm.

As a preferable technical scheme of the invention, the content of the chlorhexidine acetate in the composition is 0.01-2.50 wt%.

As a preferable technical scheme of the invention, the deacetylation degree of the chitosan is not less than 90%.

As a preferable technical scheme of the invention, the weight ratio of the cortex dictamni extract, the fructus kochiae extract and the herba schizonepetae extract is (0.5-1.5): (0.5-1.5): (0.5-1.5).

The second aspect of the invention provides the application of the silver ion-containing itching-relieving, skin-tendering, skin-protecting, moisturizing and antibacterial compound, which is applied to one of washing products, textiles, non-woven fabrics, clothes, bedding products, household products and medical products.

The third aspect of the invention provides an antibacterial liquid formulation, which comprises 5-20 wt% of the above itching-relieving, skin-tendering, skin-caring and moisturizing antibacterial compound containing silver ions, 0.1-2 wt% of an auxiliary agent, and pure water added to 100wt%.

The fourth aspect of the invention provides an antibacterial gel, which comprises 5-20 wt% of the above itching-relieving, skin-tendering, skin-protecting, moisturizing and antibacterial compound containing silver ions, 0.1-1.8 wt% of a thickening agent, 0.1-2 wt% of an auxiliary agent, and pure water added to 100wt%.

Has the advantages that: the itching-relieving, skin-tendering, skin-protecting and moisturizing antibacterial compound containing silver ions can be applied to preparing various washing and protecting articles with different dosages according to needs, a plurality of raw materials rich in functions of clearing heat, dispelling wind, relieving sore throat, resisting inflammation, resisting bacteria and easing pain are adopted, and the raw materials supplement each other, so that the heat-clearing, detoxifying, stopping bleeding, promoting tissue regeneration and improving the immune function of a user can be realized, and thus the effects of resisting virus, resisting bacteria and diminishing inflammation are achieved.

In addition, the application range of the various preparation washing and nursing products prepared by the invention is wide, the products can be suitable for infection of various bacteria, fungi, viruses and the like of nasal cavities, oral cavities, throats, surface skins, human genitals, upper and lower respiratory tracts, lungs, anorectums and the like, can quickly sterilize, deeply sterilize and multiply, and have stable sterilization effect and quick response. Moreover, the Chinese medicinal composition can play a role in stopping bleeding and promoting tissue regeneration to a great extent, promotes the healing of wound surfaces, keeps scars, has no toxic or side effect, and is convenient to use.

In addition, the compound containing silver ions and having the functions of relieving itching, tendering skin, protecting skin, moisturizing and resisting bacteria adopts a proper amount of chitosan, silver ions and/or chlorhexidine acetate, and the content of the chitosan, the silver ions and/or the chlorhexidine acetate is regulated and controlled, so that the dosage of the components is effectively reduced on the premise of ensuring the full play of the antibacterial and antipruritic effects. In addition, the chitosan is compounded and modified, so that the killing effect on staphylococcus aureus is further improved, the killing speed is increased, and the chitosan has a better and more obvious sterilization effect in a shorter time.

Detailed Description

The invention will be further understood by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. When describing embodiments of the present application, the use of "preferred," "preferably," "more preferred," and the like, is meant to refer to embodiments of the invention that may provide certain benefits, under certain circumstances. However, other embodiments may be preferred, under the same or other circumstances. In addition, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, nor is it intended to exclude other embodiments from the scope of the invention.

The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.

When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.

The invention provides a silver ion-containing itching-relieving, skin-tendering, skin-protecting, moisturizing and antibacterial compound, which is prepared from plant extracts and silver ions; the raw materials for preparing the chitosan-chlorhexidine acetate copolymer comprise chitosan and/or chlorhexidine acetate; the plant extract comprises a component A and/or a component B, wherein the component A comprises a callicarpa nudiflora extract, a honeysuckle extract, a sophora flavescens extract, a phellodendron extract and a wormwood extract; the component B comprises a cortex dictamni extract, a fructus kochiae extract, a herba schizonepetae extract and a stiff silkworm extract.

In some preferred embodiments, the raw material of the silver ion-containing anti-itch, skin-tendering, skin-protecting, moisturizing and antibacterial complex further comprises a humectant component. The particular type of humectant component is not particularly limited in the present invention and any of a variety of humectant components known to those skilled in the art may be selected.

Further, the humectant components include vitamins, niacinamide (NMN, NAD), hyaluronic acid (hyaluronic acid), camellia seed oil, glycerin, ceramide, avocado oil, olive oil, sorbitol, sodium lactate, hydroxyethyl urea, panthenol, and the like.

Further, the humectant component includes at least one of glycerin, camellia seed oil, vitamins, niacinamide (NMN, NAD), hyaluronic acid (hyaluronic acid), camellia seed oil, glycerin, ceramide, avocado oil, olive oil, sorbitol, sodium lactate, hydroxyethyl urea, panthenol, and the like.

In the invention, the content of the humectant component can be adjusted according to actual needs; preferably, the content of the humectant component accounts for 0.1 to 2 weight percent of the weight of the silver ion-containing anti-bacterial compound for relieving itching, tendering skin, moisturizing skin.

The silver ions have extremely strong bactericidal performance and no harm to people, so the silver bactericide is a common inorganic bactericide. Silver in the silver-based antibacterial agent has two existing forms of a nano silver simple substance and silver ions, wherein the nano silver simple substance also plays an antibacterial role by being converted into the silver ions, so the antibacterial effect is better when the silver exists in the form of the silver ions.

In some embodiments, the silver ion is present in the composition in an amount of 10 to 1500ppm; further, the content of the silver ions in the composition is 80-800 ppm; further, the content of silver ions in the composition is 100 to 800ppm.

The chlorhexidine acetate referred to in this application is: the chloroguanadine, chlorhexidine acetate, chlorohexamethylene biguanide and chlorhexidine hydrochloride can kill some viruses while resisting bacteria due to chlorine atoms in the structure, has wide antibacterial spectrum, has a killing effect on most gram-positive bacteria and gram-negative bacteria, has an effect on pseudomonas aeruginosa due to chlorhexidine acetate, and is often used for disinfecting hands, skin, wound surfaces and instruments before operation.

In some embodiments, the chlorhexidine acetate is present in the composition in an amount of 0.01 to 2.50wt%; further, the content of the chlorhexidine acetate in the composition is 0.15-0.25 wt%; preferably, chlorhexidine acetate is present in the composition in an amount of 0.2wt%.

The applicant finds that when a proper amount of silver ions and chlorhexidine acetate are added into the antibacterial composition, the antibacterial efficiency of the composition can be remarkably improved, and the killing efficiency of the composition on escherichia coli, staphylococcus aureus, pseudomonas aeruginosa and the like is improved at the same time. The applicant speculates that the interaction between the chlorine atom in the chlorhexidine acetate structure and other components in the system can act with pathogenic bacteria such as escherichia coli, and destroy the proteins in the structures of the bacteria and viruses to lose the activity. Meanwhile, silver ions have positive charges in the structure, exist in a free state, and can be combined with various enzymes, so that the death of microorganisms such as staphylococcus aureus is promoted. Under the synergistic action of silver ions and chlorhexidine acetate, the composition can effectively change the living environment of microorganisms such as staphylococcus aureus, pseudomonas aeruginosa and the like, so that the microorganisms are more difficult to survive, and simultaneously, the destruction to the structures of the microorganisms is mutually promoted, thereby obviously improving the antibacterial efficiency of the composition.

The chitosan (chitosan) chitin N-deacetylated product has a similar chemical structure of chitin, chitosan and cellulose, wherein the cellulose is hydroxyl at the C2 position, and the chitin and chitosan are respectively replaced by an acetamido and an amino at the C2 position, and the chitin and chitosan have a plurality of unique properties such as biodegradability, cell affinity and biological effect, especially chitosan containing free amino is the only basic polysaccharide in natural polysaccharide. The amino group in the chitosan molecular structure has stronger reactivity than the acetamido group in the chitin molecule, so that the polysaccharide has excellent biological function and can carry out chemical modification reaction. Therefore, chitosan is considered to be a functional biomaterial with greater potential for use than cellulose.

In some embodiments, the weight ratio of chitosan to plant extract is 1: (4-10); further, the weight ratio of the chitosan to the plant extract is 1:8.

in some embodiments, the chitosan has a degree of deacetylation of no less than 90%; more preferably, the viscosity of the chitosan is 20 to 1000mpa.s. The viscosity of the present application is the viscosity obtained by testing at 25 degrees celsius in a conventional manner. The chitosan of the present application may be conventional chitosan on the market, for example, food grade chitosan of Nantong Lvjingshen bioengineering, inc. may be selected.

The applicant finds that when a proper amount of silver ions and chlorhexidine acetate are adopted in the application, the antibacterial efficiency of the composition can be improved, and the antibacterial rate of the composition can be remarkably improved, so that the composition can take effect in a shorter time, and particularly when chitosan with higher deacetylation degree and more proper viscosity is selected, the sterilization rate of the composition to staphylococcus aureus within 2 minutes can be as high as 41.07 percent and is far higher than the sterilization effect index requirement, and even is slightly higher than the index requirement of a stock solution within 5 minutes. Probably because the chitosan with a specific deacetylation degree has a certain antibacterial effect, when the composition is prepared into a specific product for use, the chitosan can be quickly spread on the surface of an application part through the lower surface tension of the hydrophilic group and the hydrophobic group in the structure, and high-activity components such as silver ions, chlorhexidine acetate and the like in the composition are contacted with the application part, so that the penetration of the chitosan to the application part is promoted, and the chitosan coats microorganisms such as staphylococcus aureus and the like, so that the chitosan can take effect in a shorter time. Meanwhile, under the synergistic effect of other plant extracts, chitosan with a specific deacetylation degree and a specific viscosity can form a gel-like protective film on an application part, so that active oxygen components in the environment can be prevented from damaging active components such as silver ions, chlorhexidine acetate and the like, and the composition can be effectively promoted to inhibit and kill the microorganisms more efficiently and more quickly.

The plant extract comprises a component A and/or a component B, wherein the component A comprises a callicarpa nudiflora extract, a honeysuckle extract, a radix sophorae flavescentis extract and a cortex phellodendri extract; the component B comprises a cortex dictamni extract, a fructus kochiae extract, a herba schizonepetae extract and a stiff silkworm extract.

Callicarpa nudiflora (academic name: callicarpa nudiflora hook. Et Arn.) is Verbenaceae, and can reach 7 m; old branches have no hair and obvious skin holes, and branches with dense grayish brown color and hairy hair of twigs, petioles and inflorescences. The leaves are oval and oblong in shape and are coated with needles, the surfaces of the leaves are dark green, the leaves become black after being dried, the polyspora rosea is developed, and the bracts are linear or coated with needles; calyx, corolla purple or pink, anther oval, tiny, nearly spherical, red, flowering in 6-8 months, and bearing fruit in 8-12 months. Callicarpa nudiflora She Yaoyong has hemostatic, analgesic, blood stasis dispelling, and repercussive effects. Treating traumatic hemorrhage, traumatic injury swelling and pain, rheumatic swelling and pain, pulmonary tuberculosis hemoptysis, and gastrointestinal hemorrhage; the research on the chemical components and pharmacological action of Callicarpa nudiflora shows that the Callicarpa nudiflora extract mainly contains flavone, tannin, triterpenes, phenols and other components, wherein the total flavone extract has the effects of resisting thrombosis, reducing the viscosity of whole blood, inhibiting platelet aggregation, resisting inflammation, resisting bacteria and the like. In the invention, the callicarpa nudiflora extract can be obtained by purchase or self-made; preferably, the callicarpa nudiflora extract in the invention is prepared by a conventional preparation method.

In some embodiments, the detailed preparation method of the callicarpa nudiflora extract is as follows:

weighing Callicarpa nudiflora raw materials, crushing, screening by a 20-60 mesh sieve, adding a proper amount of 55% ethanol for precipitation, carrying out ultrasonic crushing and suction filtration to obtain filtrate, discharging, evaporating to obtain a crude product, adding 75% methanol for dissolution, subpackaging and warehousing.

In the present invention, the detailed preparation method of the callicarpa nudiflora extract is a technical method well known to those skilled in the art. The specific indexes refer to the content disclosed in Chinese patent CN 202010325619.

The flos Lonicerae is dried bud or flower with initial blossom of Lonicera Japonica of Caprifoliaceae. Is rod-shaped, has thick upper part and thin lower part, is slightly bent, has a length of 2-3cm, an upper diameter of 3mm, a lower diameter of 1.5mm, and has a yellowish white or greenish white surface, and is used for promoting hair growth. The main effective components are chlorogenic acid (chlorogenic acid) and Luteolin (Luteolin). Chlorogenic acid is widely present in plants, has high content in flos Lonicerae and Eucommiae cortex, and has wide pharmacological action. Chlorogenic acid has wide application in medicine, daily chemical industry, food and other fields. The honeysuckle extract is an extract extracted from a natural plant honeysuckle, mainly contains chlorogenic acid, is brown powder in color, and can be used as a raw material of medicines, health-care products and cosmetics. The honeysuckle extract has the functions of resisting bacteria and enhancing the immune function, and tests show that the honeysuckle has the inhibiting effect on typhoid bacillus, paratyphoid bacillus, escherichia coli, proteus bacillus, pseudomonas aeruginosa, bordetella pertussis, vibrio cholerae, staphylococcus, streptococcus, diplococcus pneumoniae, meningococcus and the like. The honeysuckle extract also has the function of inhibiting the synthesis of drug-resistant bacteria protein, has obvious stimulation effect on the respiration of staphylococcus aureus drug-resistant plants, is mainly used for treating internal and external inflammations caused by drug-resistant strains, such as pulmonary tuberculosis complicated with respiratory tract infection, pneumonia, acute bacillary dysentery and diarrhea, and is also used for reducing the bacteria-carrying rate of the throat.

In the present invention, the honeysuckle extract can be obtained commercially or by self-production, and can be prepared by the method of chinese patent CN202010325619, for example.

The sophora flavescens extract is an alkaloid extracted from sophora flavescens (Sophoraflavoscens) of sophora genus of Leguminosae. Radix Sophorae Flavescentis is dried root of radix Sophorae Flavescentis of Leguminosae, collected in spring and autumn, removed root head and branch root, cleaned, dried, or sliced and dried. It is bitter and cold. Has the functions of clearing heat, drying dampness, killing parasites and promoting urination. Can be used for treating dysentery with heat, hematochezia, jaundice, anuresis, leucorrhea with red and white discharge, pudendal swelling, pudendal pruritus, eczema, skin pruritus, scabies, tinea, leprosy, and trichomonas vaginitis by external application. The raw material has tough root, coarse fibrous cross section and yellow-white color. Light smell, extremely bitter taste. The radix Sophorae Flavescentis extract contains matrine (matrine), oxymatrine (oxymatrine), oxymatrine (sodium-anol), N-methylceupatorine (N-methylcytisine), anagerine (anagyrine), bap-ifinoline (bap-ifinoline), dehydromatrine (Sophorcarpine), d-isokurarine (d-isomatrine), kuraridine (kurarid-in), norkurarinone (norkurarinone), kurarinol (kurarinol), neokurarinol (neo-kurarinol), norkurarinol (norkurarinol), isokurarinone, and formononetin (formononetin).

In the present invention, the sophora flavescens extract can be obtained commercially or by self-production, and can be prepared by the method of chinese patent CN202010325619, for example.

The phellodendron extract of the present invention is a dried bark of phellodendron amurense (phellodendron chinense) belonging to the family rutaceae. This is commonly called Chuan Huang Bai. Peeling the bark, removing the coarse bark, and drying in the sun. The cortex Phellodendri extract is extracted from dried bark of phellodendron amurense or phellodendron amurense belonging to Rutaceae. Functions and indications: clear heat and dry dampness, purge fire and remove heat, remove toxicity and cure sore. Can be used for treating dysentery due to damp-heat pathogen, jaundice, leukorrhagia, stranguria caused by heat pathogen, tinea pedis, hectic fever due to yin-deficiency, night sweat, spermatorrhea, pyocutaneous disease, toxic swelling, eczema, and pruritus. Salted cortex phellodendri is used for nourishing yin and reducing internal heat. Can be used for treating hyperactivity of fire due to yin deficiency, night sweat and steaming bone.

In the present invention, the phellodendron extract can be obtained commercially or by self-production, and can be prepared by the method of, for example, CN202010325619

The wormwood extract is also called as folium artemisiae argyi extract, and is extracted from dry leaves of Artemisia argyi L.etVant. It is rich in flavonoids, coumarins, lactones, phenols, organic acids, steroids and triterpenes, wherein the phenols comprise phenol, naphthol, kaempferol and the like. The above-mentioned several phenolic compounds are further favorable for raising antibacterial effect of said compound, and can further raise the killing rate of said compound for several pathogenic bacteria of colibacillus, hemolytic streptococcus, pseudomonas aeruginosa and staphylococcus aureus, etc.

The method for extracting the wormwood extract is not particularly limited in this application, and can be obtained by extracting in a manner well known to those skilled in the art, such as: drying folium Artemisiae Argyi 10kg, extracting with 70% ethanol solution under reflux for 3 times, mixing, recovering solvent under reduced pressure, concentrating, and extracting with petroleum ether, chloroform, ethyl acetate, and n-butanol respectively. Wherein the components and the proportion of the extraction solvent are adjusted according to actual requirements.

In the invention, the inventor further finds that the honeysuckle extract, the sophora flavescens extract, the phellodendron bark extract, the callicarpa nudiflora extract, the wormwood extract, the chitosan and the silver ions are compounded, and a remarkable synergistic effect can be further generated, so that the beauty-care tea has excellent effects of quickly sterilizing and stopping bleeding, and also has excellent effects of promoting tissue regeneration and tightening skin. After the four plant extracts are compounded with the chitosan and the silver ions, the chitosan gel has biocompatibility, the skin barrier repairing effect of active ingredients in the plant extracts can be improved, the regeneration effect of collagen is promoted, and the effect of promoting tissue regeneration is achieved quickly. Meanwhile, the applicant also finds that the compound use of the plant extracts can also greatly relieve the symptoms of irritation, allergy and the like in the use process of the composition, effectively avoid the conditions, and especially improve the allergy condition under the premise that the system contains silver ions and chlorhexidine acetate at the same time. Probably because some effective components (especially chlorhexidine acetate) in the system have certain stimulation to some sensitive skins and are easy to cause allergy, and because the effective components in the system can act with the components such as the chlorhexidine acetate and the like under the compounding of the plant extracts, the direct contact between the effective components and the skins is reduced, and the occurrence of symptoms such as the allergy is reduced to a great extent.

In some embodiments, the a component further comprises one or more of angelica sinensis extract, isatis root extract, dandelion extract, plantain extract, leonurus extract, cnidium monnieri fruit extract, grapefruit extract, aralia chinensis extract, and bock greenbrier rhizome extract.

The radix isatidis in the radix isatidis extract is the root of Isatis tinctoria L (Isatisticillatoria L.) and Isatistigotica fort (Isatistigotica fort.) of cruciferae; or rhizomes and roots of Kalimeris indica (Baphicacanthus cusia (Nees) Brem.) of Acanthaceae. The roots of Isatis tinctoria contain indigoside (Indoxyl-beta-glucoside), isatin (Isatin), indigo (Indigo), isatis tinctoria B (Isatanb), uridine (Uridine), uracil (Uracil), hypoxanthine (Hypoxanthine), salicylic acid (Salicylicid), qingdainone (Qingdainone), daucosterol (Daucosterol), beta-Sitosterol (beta-Sitosterol), isatin, propylin and butylin. Also contains vegetable protein, resin, saccharide, sinapin, various amino acids and trace elements. Contains antibacterial substances against gram-positive and gram-negative bacteria. The radix Isatidis contains anthraquinone and beta-sitosterol. The isatis root extract is suitable for inhibiting various bacteria and viruses, and has obvious effect on staphylococcus aureus, escherichia coli, typhoid bacillus, paratyphoid bacillus and dysentery bacillus.

The dandelion extract in the invention is dandelion herb containing taraxasterol, choline, inulin, pectin and the like. The root contains taraxanol, psi-gluglucosol, taraxasterol, beta-balsamic alcohol, stigmasterol, beta-sitosterol, choline, organic acid, fructose, sucrose, glucose, glucoside, resin, rubber, etc. She Hanshe flavin, butterfly meiflavin, phylloquinone, etc. The flower contains Arnica diol, lutein and cantaxanthin. The pollen contains beta-sitosterol, 5 z-stigmast-7-ene-3 beta-ol, folic acid and vitamin C. The green calyx contains phylloquinone. The flower stem contains beta-sitosterol and beta-resinol. The dandelion extract is used for treating liver and gallbladder obstruction, improving liver function, promoting bile secretion and as diuretic. Dandelion extract is applied to liver inflammation and congestion, and is one of the most effective antidote herbs, which plays a role of filtering blood flow, gall bladder, liver, kidney poisoning and waste products, and it can stimulate bile secretion and help the body discharge excess moisture produced by damaged liver.

Plantago asiatica (PlantagoasiaLinn.) is a plant of the Plantaginaceae (Plantaginaceae) genus Plantaginaceae. Herba plantaginis, herba Ranunculi Japonici, herba Swertiae Dilutae, radix Angelicae Pubescentis, radix Polygoni Multiflori, ma Xi, herba Ardisiae Japonicae, herba Oenotherae Erythrosepalae, herba Lysimachiae Foenumgraeci, lichen, and oviductus Ranae. The plantain herb extract is a diuretic and dampness-excreting medicine and mainly used for treating edema oliguria, heat stranguria, pain and summer-heat damp diarrhea. Oral administration: decocting 15-30 g (doubling fresh product); or pounded juice. External application: appropriate amount of the raw materials are pounded and applied, and then juiced and applied or decocted and washed. Mainly used for clearing heat and promoting urination, eliminating phlegm, cooling blood and detoxifying. Can be used for treating edema, oliguria, pyretic stranguria, pain, summer-heat, damp diarrhea, dysentery, phlegm heat, cough, hematemesis, epistaxis, carbuncle, swelling, and sore. The herba plantaginis extract is prepared from herba plantaginis of Plantaginaceae as raw material by extracting brown yellow powder, and contains major effective components such as plantain, aucubin, ursolic acid, beta-sitosterol, vitamin B, C, etc. It is commonly indicated for edema, oliguria, heat stranguria, pain, summer-heat dampness, dysentery, phlegm-heat cough, hematemesis, epistaxis, carbuncle, swelling and sore. Can increase urine volume, excretion of urea, chloride, uric acid, etc., has expectorant, antitussive and antibacterial effects, and can increase airway secretion and facilitate discharge of diluted sputum.

The cnidium fruit extract in the invention comprises cnidium fruit, wild fennel, wild carrot seed, snake rice and snake chestnut. Fructus Cnidii is dried mature fruit of cnidium monnieri (L.) DC of Umbelliferae. Collected in summer and autumn when the fruits are ripe, removed of impurities and dried in the sun. Has the functions of warming kidney, strengthening Yang, eliminating dampness, dispelling wind and killing parasites. Can be used for treating sexual impotence, cold womb, leukorrhagia due to cold-dampness, and lumbago due to damp arthralgia; externally treating vulvar eczema and pruritus vulvae of women; the efficacy of trichomonas vaginitis. Can be purchased from the market or prepared according to the conventional mode in the field.

The Chinese Aralia extract is Chinese Aralia (Aralia chinensis L.) which is also called bur bag, sparrow bag, bird bed bag and Aralia chinensis, and root bark and stem bark are used as medicines. Can be harvested all year round, cut into segments, dried in the sun and extracted by a conventional method to obtain the components. The Aralia chinensis structure is rich in saponin, triterpenoid saponin, aldehyde substances, alkaloid, volatile oil and other components, and has good antibacterial and disinfectant effects. The bock greenbrier rhizome extract is a component obtained by extracting the rhizome of bock greenbrier rhizome (also called smilax china), is rich in diosgenin and a plurality of saponins consisting of diosgenin, and also contains components such as alkaloid, phenols, amino acid, organic acid, saccharides and the like. Grapefruit extract is a component extracted from the dried outer peel of ripe or near ripe grapefruit. The herba Leonuri extract is extracted from fresh or dried aerial parts of herba Leonuri belonging to Labiatae.

In some embodiments, the weight ratio of the cortex dictamni extract, the fructus kochiae extract and the herba schizonepetae extract is (0.5-1.5): (0.5-1.5): (0.5-1.5).

The cortex dictamni extract is a component obtained by extracting root bark of perennial herb Dictamni and stenotropha She Baixian of Rutaceae, and has different degrees of inhibition effects on various pathogenic fungi such as trichophyton violaceum, trichophyton concentricum and trichophyton schoenleinii. The Kochia scoparia extract is a component obtained by extracting dry mature fruits of Kochia scoparia of Chenopodiaceae, and has an inhibiting effect on dermatophytes such as Xanthophytes schoenleinii and Microsporum olgensis. The herba schizonepetae extract is a component obtained by extracting perennial plant herba schizonepetae (alias: cardamine, artemisia rupestris and stachys aspera) of schizonepeta in Labiatae, and is used as a dry stem leaf and a flower spike of the herba schizonepetae. The fresh and tender buds have the best sedation for children, the schizonepeta leaves are yellow green, the square stems are slightly purple, the cross sections are yellow white, and the spikes are slightly black, purple, yellow and green. Mild taste, warm nature, no toxicity and strong fragrance. Schizonepeta tenuifolia is one of the commonly used herbs for inducing sweat and relieving fever, and can dispel phlegm, dispel wind and cool blood. It is indicated for influenza, headache, cold, heat, sweating and vomiting.

The stiff silkworm (also called white stiff silkworm, tencel and the like) extract in the application is a larva dried body killed by infecting (or artificially inoculating) larva of 4-5-year-old silkworm (bombyx mori) of bombyx mori, belonging to the family Bombycidae. Can dispel wind, relieve convulsion, resolve phlegm and dissipate stagnation. Can be used for treating convulsion, sore throat, skin pruritus, submandibular lymphadenitis, and facial paralysis.

The applicant found that the addition of component B together with silver ions and chlorhexidine acetate to the plant extract greatly improved the performance of the composition in several complete skin irritation experiments, giving it a very pronounced micro-irritation. The synergistic effect of active ingredients in the cortex dictamni extract, the fructus kochiae extract, the herba schizonepetae extract and the like, chlorhexidine acetate and silver ions is mainly utilized, so that on one hand, the direct contact of high-activity ingredients in the cortex dictamni extract, the fructus kochiae extract, the herba schizonepetae extract and the like with skin is reduced, and the stimulation of high-concentration high-activity ingredients to the skin is avoided; on the other hand, the high-activity components are coated, so that the acting force between the high-activity components and the skin is slowed down, and the irritation of the high-activity components to the skin is effectively reduced.

The second aspect of the invention discloses the application of the silver ion-containing itching-relieving, skin-tendering, skin-protecting, moisturizing and antibacterial compound, which is applied to one of washing products, textiles, non-woven fabrics, clothes, bedding products, household products and medical products.

The third aspect of the invention provides an antibacterial liquid, which comprises 5-20 wt% of the above itching-relieving, skin-tendering, skin-protecting, moisturizing and antibacterial compound containing silver ions, 0.1-2 wt% of an auxiliary agent, and pure water added to 100wt%; further, the method comprises the following steps of; the content of the silver ion-containing itching-relieving, skin-tendering, skin-protecting, moisturizing and antibacterial compound in the antibacterial liquid is 6-12 wt%; furthermore, the content of the silver ion-containing itching-relieving, skin-tendering, skin-protecting and moisturizing antibacterial compound in the antibacterial liquid is 8wt%.

The auxiliary agent in the antibacterial liquid agent can be selected from dispersing agent, penetrating agent and other components known to those skilled in the art, and can be selected according to actual requirements.

The thickening agent in the present invention includes, but is not limited to, gelatin, carrageenan, pectin, acacia, carbomer, etc. The adjuvant of the antibacterial gel agent can be selected from various components known by those skilled in the art, such as a dispersing agent, a chelating agent, a preservative, a penetrating agent and the like, and can be selected according to actual needs.

The present invention is described in detail below by way of examples, and it should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention. Wherein the component A of the plant extract is extracted according to the conventional way of Chinese patent CN202010325619 and then used, and the raw materials in the component B are all purchased and used from Xianwei ao Biotechnology Co.

Example 1: this example provides an anti-bacterial compound containing silver ions for relieving itching, tendering skin, protecting skin, moisturizing, and the compound is prepared from plant extracts, chitosan, silver ions, chlorhexidine acetate, and moisturizingA humectant component; the plant extract comprises a component A and a component B, wherein the component A comprises a callicarpa nudiflora extract, a honeysuckle extract, a sophora flavescens extract, a phellodendron extract and a wormwood extract; the component B comprises a cortex dictamni extract, a fructus kochiae extract, a herba schizonepetae extract and a stiff silkworm extract. Wherein the weight ratio of the component A to the component B is 3:1; in the component A, the weight ratio of the nakedflower beautyberry extract, the honeysuckle extract, the sophora flavescens extract, the phellodendron amurense extract and the wormwood extract is 1:1; the weight ratio of the cortex dictamni extract, the fructus kochiae extract, the herba schizonepetae extract and the stiff silkworm extract in the component B is (2); the weight ratio of the chitosan to the plant extract is 1:8; the content of the chlorhexidine acetate in the composition is 0.2wt%; the content of the silver ions was 120ppm. The deacetylation degree of the chitosan is more than 95%, and the chitosan is food-grade chitosan of Nantong Lvjingshen bioengineering Co., ltd; the content of the humectant component is 1.2wt%, and the humectant component consists of glycerin and camellia seed oil with equal weight.

The embodiment also provides an antibacterial liquid agent, which comprises the following components in percentage by weight: 8wt% of the compound containing silver ions and having the functions of relieving itching, tendering skin, protecting skin, preserving moisture and resisting bacteria, and purified water is used for supplementing to 100wt%.

Example 2: the embodiment provides an antipruritic, skin-tendering, skin-protecting, moisturizing and antibacterial compound containing silver ions, which is prepared from plant extracts, chitosan, silver ions, chlorhexidine acetate and humectant components; the plant extract comprises a component A and a component B, wherein the component A comprises 10 parts of beautyberry extract, 10 parts of honeysuckle extract, 10 parts of radix sophorae flavescentis extract, 10 parts of cortex phellodendri extract, 10 parts of wormwood extract, 6 parts of angelica sinensis extract, 4 parts of isatis root extract, 6 parts of dandelion extract, 7 parts of plantain herb extract, 6 parts of motherwort extract, 4 parts of fructus cnidii extract and 5 parts of grapefruit extract; the component B comprises a cortex dictamni extract, a fructus kochiae extract, a herba schizonepetae extract and a stiff silkworm extract. Wherein the weight ratio of the component A to the component B is 3:1; the component B comprises cortex Dictamni Radicis extract, kochiae fructus extract, herba Schizonepetae extract and Bombyx Batryticatus extractThe weight ratio of (A) to (B) is 2; the weight ratio of the chitosan to the plant extract is 1:8; the content of the chlorhexidine acetate in the composition is 0.2wt%; the content of the silver ions was 120ppm. The deacetylation degree of the chitosan is more than 95%, and the chitosan is food-grade chitosan of Nantong Lvjingshen bioengineering Co., ltd; the humectant component content was 1.2wt%, which consisted of equal weight of glycerin and camellia seed oil.

The embodiment also provides an antibacterial liquid agent, which comprises the following components in percentage by weight: 8wt% of the compound containing silver ions and having the functions of relieving itching, tendering skin, protecting skin, moisturizing and resisting bacteria, and purified water is added to make up to 100wt%.

Example 3: the embodiment provides a silver ion-containing itching-relieving, skin-tendering, skin-protecting, moisturizing and antibacterial compound which is prepared from raw materials including plant extracts, chitosan, silver ions and humectant components; the plant extract comprises a component A and a component B, wherein the component A comprises 10 parts of beautyberry extract, 10 parts of honeysuckle extract, 10 parts of radix sophorae flavescentis extract, 10 parts of cortex phellodendri extract, 10 parts of wormwood extract, 6 parts of angelica sinensis extract, 4 parts of isatis root extract, 6 parts of dandelion extract, 7 parts of plantain herb extract, 6 parts of motherwort extract, 4 parts of fructus cnidii extract and 5 parts of grapefruit extract; the component B comprises a cortex dictamni extract, a fructus kochiae extract, a herba schizonepetae extract and a stiff silkworm extract. Wherein the weight ratio of the component A to the component B is 3:1; the weight ratio of the cortex dictamni extract, the fructus kochiae extract, the herba schizonepetae extract and the stiff silkworm extract in the component B is (2); the weight ratio of the chitosan to the plant extract is 1:8; the content of the silver ions was 120ppm. The deacetylation degree of the chitosan is more than 95%, and the chitosan is food-grade chitosan of Nantong Lvjingshen bioengineering Co., ltd; the content of the humectant component is 1.2wt%, and the humectant component consists of glycerin and camellia seed oil with equal weight.

Example 4: the embodiment provides an antipruritic, skin-tendering, skin-protecting, moisturizing and antibacterial compound containing silver ions, which is prepared from plant extracts, chitosan, silver ions, chlorhexidine acetate and humectant components; the plant extract comprises a component A, wherein the component A comprises 10 parts of beautyberry extract, 10 parts of honeysuckle extract, 10 parts of radix sophorae flavescentis extract, 10 parts of cortex phellodendri extract, 10 parts of wormwood extract, 6 parts of angelica sinensis extract, 4 parts of radix isatidis extract, 6 parts of dandelion extract, 7 parts of plantain herb extract, 6 parts of motherwort extract, 4 parts of fructus cnidii extract and 5 parts of grapefruit extract. Wherein the weight ratio of the chitosan to the plant extract is 1:8; the content of the chlorhexidine acetate in the composition is 0.2wt%; the content of the silver ions was 120ppm. The deacetylation degree of the chitosan is more than 95%, and the chitosan is food-grade chitosan of Nantong Lvjingshen bioengineering Co., ltd; the content of the humectant component is 1.2wt%, and the humectant component consists of glycerin and camellia seed oil with equal weight.

Example 5: the embodiment provides an anti-bacterial compound containing silver ions and having the functions of relieving itching, tendering skin, protecting skin and moisturizing, and the preparation raw materials comprise plant extracts, silver ions, chlorhexidine acetate and humectant components; the plant extract comprises a component A and a component B, wherein the component A comprises 10 parts of beautyberry extract, 10 parts of honeysuckle extract, 10 parts of radix sophorae flavescentis extract, 10 parts of cortex phellodendri extract, 10 parts of wormwood extract, 6 parts of angelica sinensis extract, 4 parts of isatis root extract, 6 parts of dandelion extract, 7 parts of plantain herb extract, 6 parts of motherwort extract, 4 parts of fructus cnidii extract and 5 parts of grapefruit extract; the component B comprises a cortex dictamni extract, a fructus kochiae extract, a herba schizonepetae extract and a stiff silkworm extract. Wherein the weight ratio of the component A to the component B is 3:1; the component B comprises cortex Dictamni Radicis extract, kochiae fructus extract, herba Schizonepetae extract and Bombyx BatryticatusThe weight ratio of the extract is 2; the weight ratio of the chitosan to the plant extract is 1:8; the content of the chlorhexidine acetate in the composition is 0.2wt%; the content of the silver ions is 120ppm; the humectant component content was 1.2wt%, which consisted of equal weight of glycerin and camellia seed oil.

The embodiment also provides an antibacterial liquid agent, which comprises the following components in percentage by weight: 8wt% of the compound containing silver ions and having the functions of relieving itching, tendering skin, protecting skin and resisting moisture, and purified water is complemented to 100wt%.

Example 6: the embodiment provides an antipruritic, skin-tendering, skin-protecting, moisturizing and antibacterial compound containing silver ions, which is prepared from plant extracts, chitosan, silver ions, chlorhexidine acetate and humectant components; the plant extract comprises a component A and a component B, wherein the component A comprises 6 parts of Chinese angelica extract, 4 parts of isatis root extract, 6 parts of dandelion extract, 7 parts of plantain extract, 6 parts of motherwort extract, 4 parts of common cnidium fruit extract, 5 parts of grapefruit extract and 10 parts of wormwood extract; the component B comprises a cortex dictamni extract, a fructus kochiae extract, a herba schizonepetae extract and a stiff silkworm extract. Wherein the weight ratio of the component A to the component B is 3:1; the weight ratio of the cortex dictamni extract, the fructus kochiae extract, the herba schizonepetae extract and the stiff silkworm extract in the component B is (2); the weight ratio of the chitosan to the plant extract is 1:8; the content of the chlorhexidine acetate in the composition is 0.2wt%; the content of the silver ions was 120ppm. The deacetylation degree of the chitosan is more than 95%, and the chitosan is food-grade chitosan of Nantong Lvjingshen bioengineering Co., ltd; the content of the humectant component is 1.2wt%, and the humectant component consists of glycerin and camellia seed oil with equal weight.

Example 7: this example provides a silver ion-containing anti-bacterial compound for relieving itching, tendering skin, protecting skin, moisturizing, and the like, which is prepared from the following raw materialsPlant extract, chitosan, silver ions, chlorhexidine acetate and humectant component; the plant extract comprises a component A and a component B, wherein the component A comprises 10 parts of beautyberry extract, 10 parts of honeysuckle extract, 10 parts of radix sophorae flavescentis extract, 10 parts of cortex phellodendri extract, 10 parts of wormwood extract, 6 parts of angelica sinensis extract, 4 parts of isatis root extract, 6 parts of dandelion extract, 7 parts of plantain herb extract, 6 parts of motherwort extract, 4 parts of fructus cnidii extract and 5 parts of grapefruit extract; the component B comprises a cortex dictamni extract, a fructus kochiae extract, a herba schizonepetae extract and a stiff silkworm extract. Wherein the weight ratio of the component A to the component B is 3:1; the weight ratio of the cortex dictamni extract, the fructus kochiae extract, the herba schizonepetae extract and the stiff silkworm extract in the component B is (2); the weight ratio of the chitosan to the plant extract is 1:8; the content of the chlorhexidine acetate in the composition is 0.2wt%; the content of the silver ions was 120ppm. The deacetylation degree of the chitosan is more than 85 percent, and the chitosan is food-grade chitosan of Nantong Lvjingshen bioengineering Co., ltd; the content of the humectant component is 1.2wt%, and the humectant component consists of glycerin and camellia seed oil with equal weight.

Example 8: the embodiment provides a silver ion-containing itching-relieving, skin-tendering, skin-protecting, moisturizing and antibacterial compound which is prepared from raw materials comprising plant extracts, chitosan and humectant components; the plant extract comprises a component A and a component B, wherein the component A comprises 10 parts of beautyberry extract, 10 parts of honeysuckle extract, 10 parts of radix sophorae flavescentis extract, 10 parts of cortex phellodendri extract, 10 parts of wormwood extract, 6 parts of angelica sinensis extract, 4 parts of isatis root extract, 6 parts of dandelion extract, 7 parts of plantain herb extract, 6 parts of motherwort extract, 4 parts of fructus cnidii extract and 5 parts of grapefruit extract; the component B comprises a cortex dictamni extract, a fructus kochiae extract, a herba schizonepetae extract and a stiff silkworm extract. Wherein component A is reacted with component BThe weight ratio of the components is 3:1; the weight ratio of the cortex dictamni extract, the fructus kochiae extract, the herba schizonepetae extract and the stiff silkworm extract in the component B is (2); the weight ratio of the chitosan to the plant extract is 1:8; the deacetylation degree of the chitosan is more than 95%, and the chitosan is food-grade chitosan of Nantong Lvjingshen bioengineering Co., ltd; the content of the humectant component is 1.2wt%, and the humectant component consists of glycerin and camellia seed oil with equal weight.

The embodiment also provides an antibacterial liquid agent, which comprises the following components in percentage by weight: 8wt% of the compound containing silver ions and having the functions of relieving itching, tendering skin, protecting skin, resisting bacteria and preserving moisture, and purified water is added to make up to 100wt%.

Example 9: the embodiment provides a silver ion-containing itching-relieving, skin-tendering, skin-protecting, moisturizing and antibacterial compound which is prepared from raw materials including plant extracts, chitosan and humectant components; the plant extract comprises a component A and a component B, wherein the component A comprises 10 parts of callicarpa nudiflora extract, 10 parts of honeysuckle extract, 10 parts of sophora flavescens extract, 10 parts of phellodendron extract, 10 parts of wormwood extract, 6 parts of angelica sinensis extract, 4 parts of isatis root extract, 6 parts of dandelion extract, 7 parts of plantain herb extract, 6 parts of motherwort extract, 4 parts of fructus cnidii extract, 5 parts of grapefruit extract and 4 parts of bock greenbrier rhizome extract; the component B comprises a cortex dictamni extract, a fructus kochiae extract, a herba schizonepetae extract and a stiff silkworm extract. Wherein the weight ratio of the component A to the component B is 3:1; the weight ratio of the cortex dictamni extract, the fructus kochiae extract, the herba schizonepetae extract and the stiff silkworm extract in the component B is (2); the weight ratio of the chitosan to the plant extract is 1:8; the deacetylation degree of the chitosan is more than 95%, and the chitosan is food-grade chitosan of Nantong Lvjingshen bioengineering Co., ltd; the content of the humectant component is 1.2wt%, and the humectant component consists of glycerin and camellia seed oil with equal weight.

Example 10: the embodiment provides a silver ion-containing itching-relieving, skin-tendering, skin-protecting, moisturizing and antibacterial compound which is prepared from raw materials including plant extracts, chitosan and humectant components; the plant extract comprises a component A and a component B, wherein the component A comprises 10 parts of callicarpa nudiflora extract, 10 parts of honeysuckle extract, 10 parts of radix sophorae flavescentis extract, 10 parts of cortex phellodendri extract, 10 parts of wormwood extract, 6 parts of angelica sinensis extract, 4 parts of radix isatidis extract, 6 parts of dandelion extract, 7 parts of plantain herb extract, 6 parts of leonurus extract, 4 parts of fructus cnidii extract, 5 parts of grapefruit extract and 4 parts of aralia chinensis extract; the component B comprises a cortex dictamni extract, a fructus kochiae extract, a herba schizonepetae extract and a stiff silkworm extract. Wherein the weight ratio of the component A to the component B is 3:1; the weight ratio of the cortex dictamni extract, the fructus kochiae extract, the herba schizonepetae extract and the stiff silkworm extract in the component B is (2); the weight ratio of the chitosan to the plant extract is 1:8; the deacetylation degree of the chitosan is more than 95%, and the chitosan is food-grade chitosan of Nantong Lvjingshen bioengineering Co., ltd; the content of the humectant component is 1.2wt%, and the humectant component consists of glycerin and camellia seed oil with equal weight.

Example 11: the embodiment provides a silver ion-containing itching-relieving, skin-tendering, skin-protecting, moisturizing and skin-resisting compound which is prepared from raw materials including a plant extract chlorhexidine acetate and a humectant component; the plant extract comprises a component A and a component B, wherein the component A comprises 10 parts of beautyberry extract, 10 parts of honeysuckle extract, 10 parts of radix sophorae flavescentis extract, 10 parts of cortex phellodendri extract, 10 parts of wormwood extract, 6 parts of angelica sinensis extract, 4 parts of isatis root extract, 6 parts of dandelion extract, 7 parts of plantain herb extract, 6 parts of motherwort extract, 4 parts of fructus cnidii extract and 5 parts of grapefruit extract; the component B comprises a cortex dictamni extract, a fructus kochiae extract, a herba schizonepetae extract and a stiff silkworm extract. Wherein the weight ratio of the component A to the component B is 3:1; the weight ratio of the cortex dictamni extract, the fructus kochiae extract, the herba schizonepetae extract and the stiff silkworm extract in the component B is (2); the chitosan and plantThe weight ratio of extract is 1:8; the content of the chlorhexidine acetate in the composition is 0.2wt%; the content of the humectant component is 1.2wt%, and the humectant component consists of glycerin and camellia seed oil with equal weight.

Performance testing

The applicant carried out the following various performance tests on the samples of the above examples 1 to 11, and the specific test standards and results were as follows:

1. sensory requirements: the sample was poured out in small amount into a transparent glass and observed at the light inspection site. It is judged whether the criteria as required in table 1 below are met.

TABLE 1

Item	Index (I)
		Color	Meet the specified color and luster
Form of the composition	Liquid, method for producing the same and use thereof
		Smell(s)	No peculiar smell or conforming to the regulated smell
Impurities	No visible impurities

And (3) testing results: the above test samples all met the requirements of table 1.

2. Microorganism indexes are as follows: the method is carried out according to the method specified in GB15979-2002, and whether the standard meets the requirements of the following table 2 is judged.

TABLE 2

And (3) testing results: the above samples all meet the requirements of table 2.

3. The sterilization effect is as follows: the samples of examples 1 to 8 were tested for their disinfecting effect according to the method specified in "Disinfection technical Specification" 2002 edition, wherein it was judged whether or not the index requirements of Table 3 were met.

TABLE 3

Time/bacterial species	Stock solution for 2min	Stock solution for 5min	Stock solution for 10min	Stock solution for 20min
					Escherichia coli	＞90％	＞99.00％	＞99.99％	＞99.99％
Staphylococcus aureus	＞35％	＞40.00％	＞50.00％	＞91.00％
					Aerugo bacillus	＞97％	＞99.99％	＞99.99％	＞99.99％

And (3) testing results: as shown in table 4.

TABLE 4

Examples	Sterilizing effect
		Example 1	Conform to
Example 2	Conform to
		Example 3	Conform to
Example 4	Meet with
		Example 5	Meet with
Example 6	Conform to
		Example 7	Conform to
Example 8	Is not in compliance with

Wherein, the effect of the sample of the embodiment 2 is the most obvious, and the effect on the escherichia coli (2 min, 5min, 10min and 20 min) is 96.41%, 99.90%, 99.99% and 99.99% in sequence; the effects on staphylococcus aureus (2 min, 5min, 10min and 20 min) are 41.07%, 43.33%, 52.14% and 94.02% in sequence; the effects on the pseudomonas aeruginosa (2 min, 5min, 10min and 20 min) are 97.79%, 99.99% and 99.99% in sequence. While the results of example 3 and example 5 meet the specification, they are much lower than those of example 2.

4, stability: the samples of examples 1 to 8 were tested for their disinfecting effect according to the method specified in "Disinfection technical Specification" 2002 edition, wherein it was judged whether or not the index requirements of Table 5 were met.

TABLE 5

Time/bacterial species	Stock solution for 2min	Stock solution for 5min	Stock solution for 10min	Stock solution for 20min
					Candida albicans	＞99.99％	＞99.99％	＞99.99％	＞99.99％

The samples of examples 1 to 7 were satisfactory, and the sample of example 8 was not.

5. The requirement of toxicological safety: the determination is made according to the method prescribed by the Ministry of health, disinfection technical Specification, 2002 edition, wherein the criteria are met or not according to the index requirements of Table 6.

TABLE 6

Item	Index (I)
		Skin irritation test	Without or with slight irritation
Acute oral toxicity test	Is practically nontoxic
		Acute eye irritation test	Has no irritation
Multiple complete skin irritation tests	Without or with slight irritation
		Irritation test of vaginal mucous membrane (multiple times)	No irritation to vaginal mucosa

And (3) testing results: the samples of examples 4 and 6 were unsatisfactory, with the remaining samples being compounded.

According to the hygienic standard GB15979-2002 appendix C of the disposable hygienic product, 5% of sodium thiosulfate and 1% of lecithin, 9% of tween and 2% of histidine in PBS buffer are adopted as a neutralizer; the experiment was repeated 3 times at 19-21 ℃ for 15min with the test sample of example 2 and candida albicans, and the sterilization rates of the test sample and candida albicans were observed for 2min, 5min, 10min and 20min, respectively, and the results are shown in table 7 below.

TABLE 7

From the above results, it can be seen that the killing rate of candida albicans by the sample can reach >99.99%. Further, the rabbit mucous membrane irritation test was performed on the sample in example 2, and it was found that irritation such as erythema and edema did not occur.

The foregoing is merely a preferred embodiment of the invention and is not intended to limit the invention in any manner; as will be readily apparent to those skilled in the art from the disclosure herein, the present invention may be practiced without these specific details; however, those skilled in the art should appreciate that they can readily use the disclosed conception and specific embodiments as a basis for designing or modifying other structures for carrying out the same purposes of the present invention; meanwhile, any changes, modifications, and evolutions of the equivalent changes of the above embodiments according to the actual techniques of the present invention are still within the protection scope of the technical solution of the present invention.

Claims

1. A compound containing silver ion for relieving itching, tendering skin, caring skin, keeping moisture and resisting bacteria is characterized in that the raw materials for preparing the compound comprise plant extract and silver ion; the raw materials for preparing the chitosan-chlorhexidine acetate copolymer comprise chitosan and/or chlorhexidine acetate; the plant extract comprises a component A and/or a component B, wherein the component A comprises a nakedflower beautyberry leaf extract, a honeysuckle extract, a radix sophorae flavescentis extract, a golden cypress extract and a wormwood extract; the component B comprises a cortex dictamni extract, a fructus kochiae extract, a herba schizonepetae extract and a stiff silkworm extract; preferably, the raw materials for preparing the compound also comprise a humectant component.

2. The compound containing silver ions and having the functions of relieving itching, tendering skin, protecting skin, moisturizing and resisting bacteria as claimed in claim 1, wherein the component A further comprises one or more of angelica sinensis extract, isatis root extract, dandelion extract, plantain herb extract, motherwort extract, cnidium fruit extract, grapefruit extract, aralia chinensis extract and chinaroot greenbrier rhizome extract; preferably, the humectant component includes one or more of glycerin, camellia seed oil, vitamins, niacinamide, and hyaluronic acid.

3. The silver ion-containing antipruritic, skin-tendering, skin-protecting, moisturizing and antibacterial composition as claimed in claim 1, wherein the weight ratio of the chitosan to the plant extract is 1: (4-10).

4. The compound as claimed in claim 1, wherein the silver ion content in the composition is 10-1500 ppm.

5. The compound as claimed in claim 1, wherein the chlorhexidine acetate is present in an amount of 0.01-2.50 wt% of the composition.

6. The silver ion-containing anti-itch, skin-tendering, skin-caring, moisturizing and antibacterial complex for skin according to any one of claims 1 to 5, wherein the chitosan has a deacetylation degree of not less than 90%.

7. The compound containing silver ions and having the functions of relieving itching, tendering skin, protecting skin, moisturizing and resisting bacteria as claimed in claim 6, wherein the weight ratio of the cortex dictamni extract, the fructus kochiae extract and the herba schizonepetae extract is (0.5-1.5): (0.5-1.5): (0.5-1.5).

8. The application of the silver ion-containing itching-relieving, skin-tendering, skin-protecting, moisturizing and antibacterial compound as claimed in any one of claims 1 to 7, which is applied to one of washing products, textiles, non-woven fabrics, clothes, bedding products, household products and medical products.

9. An antibacterial liquid formulation, characterized in that it comprises 5-20 wt% of the silver ion-containing itching-relieving, skin-tendering, skin-caring, moisture-keeping and antibacterial complex of any one of claims 1-7, 0.1-2 wt% of auxiliary agent, and pure water added to 100wt%.

10. An antibacterial gel, characterized in that it comprises 5-20 wt% of the silver ion-containing itching-relieving, skin-tendering, skin-caring, moisture-keeping and antibacterial compound of any one of claims 1-7, 0.1-1.8 wt% of a thickening agent, 0.1-2% of an auxiliary agent, and pure water is added to 100wt%.