CN115299452B - Bactericidal composition containing oxadixyl - Google Patents
Bactericidal composition containing oxadixyl Download PDFInfo
- Publication number
- CN115299452B CN115299452B CN202210772861.6A CN202210772861A CN115299452B CN 115299452 B CN115299452 B CN 115299452B CN 202210772861 A CN202210772861 A CN 202210772861A CN 115299452 B CN115299452 B CN 115299452B
- Authority
- CN
- China
- Prior art keywords
- oxadixyl
- cymoxanil
- water dispersible
- dispersible granule
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- UWVQIROCRJWDKL-UHFFFAOYSA-N oxadixyl Chemical compound CC=1C=CC=C(C)C=1N(C(=O)COC)N1CCOC1=O UWVQIROCRJWDKL-UHFFFAOYSA-N 0.000 title claims abstract description 101
- 239000000203 mixture Substances 0.000 title claims abstract description 34
- 230000000844 anti-bacterial effect Effects 0.000 title abstract description 16
- 239000005756 Cymoxanil Substances 0.000 claims abstract description 101
- XERJKGMBORTKEO-VZUCSPMQSA-N (1e)-2-(ethylcarbamoylamino)-n-methoxy-2-oxoethanimidoyl cyanide Chemical compound CCNC(=O)NC(=O)C(\C#N)=N\OC XERJKGMBORTKEO-VZUCSPMQSA-N 0.000 claims abstract description 100
- 239000004562 water dispersible granule Substances 0.000 claims abstract description 69
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 claims abstract description 44
- 241000233679 Peronosporaceae Species 0.000 claims abstract description 35
- 239000004480 active ingredient Substances 0.000 claims abstract description 4
- 240000008067 Cucumis sativus Species 0.000 claims description 45
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 26
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 26
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 24
- -1 methylene dinaphthyl Chemical group 0.000 claims description 20
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 19
- 239000006229 carbon black Substances 0.000 claims description 16
- 150000002191 fatty alcohols Chemical class 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 229910019142 PO4 Inorganic materials 0.000 claims description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 12
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 12
- 239000010452 phosphate Substances 0.000 claims description 12
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 10
- 229920002472 Starch Polymers 0.000 claims description 9
- 239000008107 starch Substances 0.000 claims description 9
- 235000019698 starch Nutrition 0.000 claims description 9
- 239000004721 Polyphenylene oxide Substances 0.000 claims description 8
- 229920000570 polyether Polymers 0.000 claims description 8
- 239000012747 synergistic agent Substances 0.000 claims description 8
- 239000013530 defoamer Substances 0.000 claims description 7
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 6
- 125000003545 alkoxy group Chemical class 0.000 claims description 6
- 239000011230 binding agent Substances 0.000 claims description 6
- 239000002270 dispersing agent Substances 0.000 claims description 6
- 239000000945 filler Substances 0.000 claims description 6
- 229920001296 polysiloxane Polymers 0.000 claims description 6
- 150000004756 silanes Chemical class 0.000 claims description 6
- 239000000080 wetting agent Substances 0.000 claims description 6
- 239000005995 Aluminium silicate Substances 0.000 claims description 5
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 claims description 5
- 229960000583 acetic acid Drugs 0.000 claims description 5
- 235000012211 aluminium silicate Nutrition 0.000 claims description 5
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 5
- 239000000194 fatty acid Substances 0.000 claims description 5
- 229930195729 fatty acid Natural products 0.000 claims description 5
- 239000012362 glacial acetic acid Substances 0.000 claims description 5
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 5
- 239000011734 sodium Substances 0.000 claims description 5
- 229910052708 sodium Inorganic materials 0.000 claims description 5
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 5
- RZXLPPRPEOUENN-UHFFFAOYSA-N Chlorfenson Chemical compound C1=CC(Cl)=CC=C1OS(=O)(=O)C1=CC=C(Cl)C=C1 RZXLPPRPEOUENN-UHFFFAOYSA-N 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- 239000012752 auxiliary agent Substances 0.000 claims description 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 4
- 229920005989 resin Polymers 0.000 claims description 4
- 239000011347 resin Substances 0.000 claims description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 3
- 239000002518 antifoaming agent Substances 0.000 claims description 3
- 239000004202 carbamide Substances 0.000 claims description 3
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 claims description 3
- 239000008103 glucose Substances 0.000 claims description 3
- 229930182470 glycoside Natural products 0.000 claims description 3
- UZRCGISJYYLJMA-UHFFFAOYSA-N phenol;styrene Chemical compound OC1=CC=CC=C1.C=CC1=CC=CC=C1 UZRCGISJYYLJMA-UHFFFAOYSA-N 0.000 claims description 3
- 229920005646 polycarboxylate Polymers 0.000 claims description 3
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 claims description 3
- 229910052939 potassium sulfate Inorganic materials 0.000 claims description 3
- 235000011151 potassium sulphates Nutrition 0.000 claims description 3
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 claims description 3
- PYODKQIVQIVELM-UHFFFAOYSA-M sodium;2,3-bis(2-methylpropyl)naphthalene-1-sulfonate Chemical compound [Na+].C1=CC=C2C(S([O-])(=O)=O)=C(CC(C)C)C(CC(C)C)=CC2=C1 PYODKQIVQIVELM-UHFFFAOYSA-M 0.000 claims description 2
- 244000299906 Cucumis sativus var. sativus Species 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 57
- 238000011282 treatment Methods 0.000 description 36
- 230000000694 effects Effects 0.000 description 32
- 239000003814 drug Substances 0.000 description 25
- 239000003795 chemical substances by application Substances 0.000 description 22
- 238000000034 method Methods 0.000 description 22
- 238000011835 investigation Methods 0.000 description 16
- 239000002994 raw material Substances 0.000 description 16
- 229940079593 drug Drugs 0.000 description 13
- 239000000243 solution Substances 0.000 description 13
- 201000010099 disease Diseases 0.000 description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 12
- 239000000725 suspension Substances 0.000 description 11
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 8
- 229920000053 polysorbate 80 Polymers 0.000 description 8
- 239000008223 sterile water Substances 0.000 description 8
- 230000002195 synergetic effect Effects 0.000 description 7
- 230000001988 toxicity Effects 0.000 description 7
- 231100000419 toxicity Toxicity 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- 239000000375 suspending agent Substances 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 5
- 229920001400 block copolymer Polymers 0.000 description 5
- 239000003995 emulsifying agent Substances 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 159000000000 sodium salts Chemical class 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 4
- 238000013461 design Methods 0.000 description 4
- 230000003902 lesion Effects 0.000 description 4
- 239000000575 pesticide Substances 0.000 description 4
- 229920001568 phenolic resin Polymers 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 238000005507 spraying Methods 0.000 description 4
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 3
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 3
- 235000011130 ammonium sulphate Nutrition 0.000 description 3
- 239000003899 bactericide agent Substances 0.000 description 3
- 238000004364 calculation method Methods 0.000 description 3
- 238000007865 diluting Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000012452 mother liquor Substances 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 3
- 238000007619 statistical method Methods 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- IWOUTIHKEQOMCY-UHFFFAOYSA-N 2-ethyl-3,4,5-triphenylphenol Chemical compound C1(=CC=CC=C1)C=1C(=C(C(=C(C1)O)CC)C1=CC=CC=C1)C1=CC=CC=C1 IWOUTIHKEQOMCY-UHFFFAOYSA-N 0.000 description 2
- KXGFMDJXCMQABM-UHFFFAOYSA-N 2-methoxy-6-methylphenol Chemical compound [CH]OC1=CC=CC([CH])=C1O KXGFMDJXCMQABM-UHFFFAOYSA-N 0.000 description 2
- 229920000877 Melamine resin Polymers 0.000 description 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 2
- 241000233678 Peronosporales Species 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 238000000540 analysis of variance Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000002872 contrast media Substances 0.000 description 2
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 238000011010 flushing procedure Methods 0.000 description 2
- DNIKXCUKOGVNIO-UHFFFAOYSA-N formaldehyde;phenol;styrene Chemical compound O=C.OC1=CC=CC=C1.C=CC1=CC=CC=C1 DNIKXCUKOGVNIO-UHFFFAOYSA-N 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- 229920005610 lignin Polymers 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920001451 polypropylene glycol Polymers 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 238000009331 sowing Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- KKFBZUNYJMVNFV-UHFFFAOYSA-N 1,2-bis(2-methylpropyl)naphthalene Chemical compound C1=CC=CC2=C(CC(C)C)C(CC(C)C)=CC=C21 KKFBZUNYJMVNFV-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000219112 Cucumis Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 235000009849 Cucumis sativus Nutrition 0.000 description 1
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
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- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
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- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol Natural products CCCCCCCCCC1=CC=C(O)C=C1 IGFHQQFPSIBGKE-UHFFFAOYSA-N 0.000 description 1
- 241001223281 Peronospora Species 0.000 description 1
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- 241001281805 Pseudoperonospora cubensis Species 0.000 description 1
- 229920000142 Sodium polycarboxylate Polymers 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 150000008051 alkyl sulfates Chemical class 0.000 description 1
- 150000008052 alkyl sulfonates Chemical class 0.000 description 1
- 229940037003 alum Drugs 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 230000002155 anti-virotic effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
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- 239000011575 calcium Substances 0.000 description 1
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- 159000000007 calcium salts Chemical class 0.000 description 1
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- 239000003153 chemical reaction reagent Substances 0.000 description 1
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- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
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- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
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- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
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- 230000005923 long-lasting effect Effects 0.000 description 1
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- 230000003020 moisturizing effect Effects 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical compound CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 description 1
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
- 229920001843 polymethylhydrosiloxane Polymers 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
- A01N43/76—1,3-Oxazoles; Hydrogenated 1,3-oxazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/12—Powders or granules
- A01N25/14—Powders or granules wettable
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/34—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the groups, e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P3/00—Fungicides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pest Control & Pesticides (AREA)
- Wood Science & Technology (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Toxicology (AREA)
- Chemical & Material Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a bactericidal composition containing oxadixyl, in particular to an application of the bactericidal composition containing oxadixyl and cymoxanil in preventing and controlling cucumber downy mildew, which is mainly characterized in that: the weight ratio of oxadixyl to cymoxanil is 15: 4~4:15, the composition is prepared into water dispersible granules, and the dosage of the effective active ingredients is 228-342 g/hectare.
Description
Technical Field
The invention belongs to the technical field of pesticides, and in particular relates to a bactericidal composition containing oxadixyl.
Background
Oxadixyl, also known as antivirus alum, the english generic name oxadixyl, chemical name: 2-methoxy-N- (2-oxo-1, 3-oxazolidin-3-yl) acetyl 2',6' -dimethylanilide. The oxadixyl is an agricultural bactericide, has high control effect on pathogenic bacteria of the order peronosporales, has protection and treatment effects, and has long lasting period.
Cymoxanil, english generic name cymoxanil, chemical name: 1- (2-cyano-2-methoxyimino) -3-ethylurea. Cymoxanil is a highly effective, low-toxic fungicide, effective against fungi of the order peronosporales, such as the genus phaeomyces, the genus peronospora, and the genus monoaxial frost. Cymoxanil is mixed with other protective bactericides, and is suitable for preventing and treating diseases of vegetables, fruit trees, tobacco and the like such as cucumber, grape, tomato, litchi and the like.
Experiments show that the water dispersible granule composition is supported by the oxadixyl and cymoxanil with different action mechanisms according to a certain proportion, so that the control effect on cucumber downy mildew can be effectively improved, the control cost is reduced, and the water dispersible granule composition is high in crop safety.
Disclosure of Invention
The invention aims to provide a bactericidal composition containing oxadixyl.
The technical scheme of the invention is as follows:
a bactericidal composition containing oxadixyl, which is characterized in that: the effective active components of the bactericidal composition are oxadixyl and cymoxanil, wherein the weight ratio of the oxadixyl to the cymoxanil is 15:4-4:15, the preferred weight ratio is 1:1-4:15, and the most preferred weight ratio is 4:15.
Further, the bactericidal composition contains oxadixyl, cymoxanil, a synergistic agent, a white carbon black mixture and an auxiliary agent, and the composition is prepared into water dispersible granules.
Further, the total weight of the oxadixyl and cymoxanil in the bactericidal composition is 19-76%, and the preferred total weight is 38%.
Further, the synergistic agent is a mixture of polyethoxy modified silane and polyethoxy modified fatty alcohol or alkoxy modified polysilicone, and the weight ratio of the synergistic agent to the white carbon black is 1:1-3:1.
Further, the auxiliary agent is one or more selected from dispersing agents, wetting agents, binders, defoamers, PH regulators and fillers.
The dispersing agent is selected from one or more of alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, alkylphenol polyoxyethylene ether formaldehyde condensate phosphate, methylene dinaphthyl sodium sulfonate, lignin sodium salt or calcium salt, melamine formaldehyde resin, alkyl naphthalene sulfonate, EO-PO block polyether, styrene phenol polyoxyethylene ether phosphoric acid, alkyl naphthalene formaldehyde condensate sulfonate, alkylphenol polyoxyethylene ether phosphate, alkylphenol polyoxyethylene ether sulfonate, phenethyl phenol polyoxyethylene ether phosphate, alkyl polyoxyethylene ether sulfonate, polyoxyethylene polyoxypropylene ether block copolymer, dodecyl polyoxyethylene ether phosphate, fatty alcohol polyoxyethylene ether phosphate, nonylphenol polyoxyethylene ether phosphate, naphthalene sulfonic formaldehyde condensate sodium salt block copolymer, comb-type polycarboxylate and sodium polycarboxylate;
the wetting agent is one or more selected from sodium dodecyl benzene sulfonate, sodium diisobutyl naphthalene sulfonate, sorbitan fatty acid ester, sulfodocyl sodium salt, alkyl succinic acid sulfonate, phenethyl phenol polyoxyethylene ether phosphate, alkyl sulfate, alkyl sulfonate, alkyl naphthalene sulfonate, alkylphenol formaldehyde resin polyoxyethylene ether, triphenyl ethylphenol polyoxypropylene polyoxyethylene block polymer, sodium dodecyl sulfate, styrene phenol formaldehyde resin propylene oxide block polyether, castor oil polyoxyethylene ether, fatty alcohol polyoxyethylene ether, alkyl glycoside and fatty alcohol polyoxyethylene ether sodium sulfonate;
the binder is one or more selected from water, starch, polyvinylpyrrolidone, polyethylene glycol, glucose and polyvinyl alcohol;
the PH regulator is one or more selected from glacial acetic acid, citric acid, light calcium, potassium dihydrogen phosphate and triethanolamine;
the defoamer is one or more selected from organic silicone, fatty alcohol and fatty acid;
the filler is selected from the group consisting of: white carbon black, calcined kaolin, ammonium sulfate, potassium sulfate, talcum powder, diatomite, starch and urea.
The bactericidal composition comprises the following components in percentage by weight when being prepared into water dispersible granules: 4-60% of oxadixyl, 4-60% of cymoxanil, 3-20% of a synergistic agent and white carbon black mixture, 1-20% of a dispersing agent, 1-10% of a wetting agent, 1-20% of a binding agent, 0-3% of a defoaming agent, 0-4% of a PH regulator and 100% of a filler.
Furthermore, the bactericidal composition is used for preventing and controlling cucumber downy mildew, and the dosage of the active ingredients is 228-342 g/hectare.
Compared with the prior art, the bactericidal composition for preventing and controlling cucumber downy mildew has the following beneficial effects: (1) Compared with a single dose, the composition has more remarkable effect on preventing and treating cucumber downy mildew; (2) The two compounds with different action mechanisms are mixed, so that the generation of drug resistance of diseases can be effectively delayed, and the compound has good safety and is safe to cucumbers.
Detailed Description
The invention is further illustrated by the following examples, which are by weight, but are not limited thereto.
Application example one
Example 1 38% oxadixyl and cymoxanil Water dispersible granule
The water dispersible granule of the oxadixyl and the cymoxanil is prepared by adding 8.33% of a 96% oxadixyl raw material, 30.61% of a 98% cymoxanil raw material, 5% of a mixture of polyethoxy-modified silane and polyethoxy-modified fatty alcohol, 5% of white carbon black, 2.5% of a polyoxyethylene polyoxypropylene ether block copolymer, 3% of alkyl naphthalene sulfonate, 3% of sodium dodecyl benzene sulfonate, 3% of sodium sulfosuccinyl ester sodium salt, 0.2% of polyvinylpyrrolidone, 0.8% of citric acid, 0.2% of a silicone defoamer, 10% of starch and 100% of calcined kaolin.
Example 2 38% oxadixyl and cymoxanil water dispersible granule
8.33% of a 96% oxadixyl raw material, 30.61% of a 98% cymoxanil raw material, 8% of a mixture of polyethoxy-modified silane and polyethoxy-modified fatty alcohol, 4% of white carbon black, 4% of comb-shaped polycarboxylate, 3% of alkylphenol polyoxyethylene ether sulfonate, 3% of phenethyl phenol polyoxyethylene ether phosphate, 4% of alkyl glycoside, 1% of water, 0.5% of glucose, 0.3% of glacial acetic acid, 0.3% of fatty alcohol, 15% of starch and 100% of potassium sulfate to prepare the 38% oxadixyl cymoxanil water dispersible granule.
Example 3 38% oxadixyl and cymoxanil Water dispersible granule
8.33% of a 96% oxadixyl raw material, 30.61% of a 98% cymoxanil raw material, 4% of alkoxy modified polysilicone, 3% of white carbon black, 4% of methylene dinaphthyl sulfonate, 3% of EO-PO block polyether, 3% of diisobutyl naphthalene sulfonate, 5% of alkylphenol formaldehyde resin polyoxyethylene ether, 0.4% of an organosilicone defoamer, 0.3% of polyvinylpyrrolidone, 13% of urea, 5% of starch and 100% of calcined kaolin are added to prepare the 38% oxadixyl cymoxanil water dispersible granule.
Example 4 38% oxadixyl and cymoxanil Water dispersible granule
The water dispersible granule is prepared from 31.25% of a raw material of 96% of oxadixyl, 8.16% of a raw material of 98% of cymoxanil, 4% of alkoxy modified polysilicone, 4% of white carbon black, 4% of lignin sodium salt, 4% of alkylphenol polyoxyethylene ether phosphate, 4% of styrene-based phenol formaldehyde resin propylene oxide block polyether, 0.4% of fatty alcohol, 1% of polyvinyl alcohol, 0.5% of glacial acetic acid, 20% of ammonium sulfate and 100% of starch.
Example 5 76% oxadixyl and cymoxanil Water dispersible granule
16.67% of a raw material of the oxadixyl, 61.22% of a raw material of the cymoxanil, 2% of a mixture of polyethoxy modified silane and polyethoxy modified fatty alcohol, 1% of white carbon black, 4% of a polyoxyethylene polyoxypropylene ether block copolymer, 2% of fatty alcohol polyoxyethylene ether phosphate, 4% of styrene-based phenol formaldehyde resin propylene oxide block polyether, 0.5% of glacial acetic acid, 0.2% of a silicone defoamer and 100% of starch to prepare the 76% oxadixyl cymoxanil water dispersible granule.
Example 6 60% oxadixyl and cymoxanil Water dispersible granule
The water dispersible granule of the oxadixyl and the cymoxanil is prepared by adding 31.25% of a raw material of the oxadixyl, 30.61% of a raw material of the cymoxanil, 4% of alkoxy modified polysilicone, 4% of white carbon black, 3% of alkylphenol ethoxylate formaldehyde condensate sulfate, 3% of melamine formaldehyde resin, 3% of a triphenyl ethylphenol polyoxypropylene polyoxyethylene block polymer, 4% of sodium dodecyl sulfate, 1% of polyethylene glycol, 0.1% of fatty acid, 0.3% of citric acid and 100% of starch.
Example 7 35% oxadixyl and cymoxanil Water dispersible granule
The water dispersible granule of the oxadixyl and the cymoxanil is prepared by adding 10.41% of a 96% of an oxadixyl raw material, 25.51% of a 98% of a cymoxanil raw material, 5% of a mixture of polyethoxy-modified silane and polyethoxy-modified fatty alcohol, 5% of white carbon black, 3% of a sodium salt block copolymer of naphthalene sulfonic acid formaldehyde condensate, 3% of styrene-phenol formaldehyde resin propylene oxide block polyether, 3% of fatty alcohol polyoxyethylene ether, 0.5% of a silicone defoamer, 1% of polyethylene glycol, 4% of ammonium sulfate and 100% of talcum powder.
Example 8 19% oxadixyl and cymoxanil Water dispersible granule
The water dispersible granule is prepared from (by weight) 96% oxadixyl raw material 4.17%, 98% cymoxanil raw material 15.31%, alkoxy modified polysilicone 4%, white carbon black 4%, styrene phenol polyoxyethylene ether phosphoric acid 5%, sorbitan fatty acid ester 4%, water 1%, diatomite 8%, organic silicone defoamer 0.3% and kaolin 100%.
Implementation example II:
determination of toxicity of cymoxanil and oxadixyl to cucumber downy mildew
According to the standards of NY/T1156.3-2006 and NY/T1156.6-2006, the toxicity of the oxadixyl and cymoxanil and the ratio of 1:1, 2:5, 4:15, 15:4 and 5:2 to the cucumber downy mildew is measured by adopting a plate leaf method, and the result shows that the oxadixyl and cymoxanil are mixed according to the 5 ratios, and the synergistic effect is shown on the cucumber downy mildew. The experimental procedure was as follows:
1 purpose of test
The toxicity of the oxadixyl and cymoxanil and the mixed combinations of the oxadixyl and cymoxanil in different proportions to the cucumber downy mildew is measured indoors, the synergism is evaluated, the suitability of the oxadixyl and cymoxanil is clear, and scientific basis is provided for the research and development of the oxadixyl and cymoxanil mixture.
2 test conditions
2.1 test targets
Cucumber downy mildew (Pseudoperonospora cubensis (berk. Et curt.) roscov) is saved and supplied by the company of detection of seedlings of loving hunan.
2.2 culture conditions
The culture condition of the target to be tested and the target after the test is that the temperature is 17-22 ℃ and the relative humidity is more than 90%.
2.3 instrumentation
Beaker, conical flask, pipette, graduated cylinder, blood count plate, microscope, crop sprayer, ten thousandth electronic day, etc.
3 test design
3.1 test Agents
Oxadixyl (oxadixyl) 96% of the original drug; cymoxanil (cymoxanil) 98% of the original drug.
3.2 design of concentration of agent and formulation of solution
Oxadixyl solution: weighing 96% of raw medicine of 0.0104g of oxadixyl with a sterilized small beaker, dissolving with 0.5mL of DMF, adding a small amount of sterile water containing 0.1% of Tween80, stirring uniformly, transferring to a 100mL volumetric flask, then washing the small beaker with a proper amount of sterile water containing 0.1% of Tween80 for 3 times, transferring the flushing liquid to the volumetric flask, finally fixing the volume to 100mL, preparing 100mg/L mother liquor, and diluting with sterile water containing 0.1% of Tween80 to 10, 5, 1, 0.5, 0.1 and 0.05mg/L for later use;
cymoxanil solution: weighing 0.0102g of cymoxanil 97.5% raw medicine by a sterilized small beaker, dissolving the raw medicine by 0.5mL of DMF, adding a small amount of sterile water containing 0.1% Tween80 emulsifier, stirring uniformly, transferring the raw medicine into a 100mL volumetric flask, then washing the small beaker with a proper amount of sterile water containing 0.1% Tween80 emulsifier for 3 times, transferring the flushing liquid into the volumetric flask, finally fixing the volumetric flask to 100mL, preparing 100mg/L mother liquor, and diluting the mother liquor into 10, 5, 1, 0.5, 0.1 and 0.05mg/L concentrations by using sterile water containing 0.1% Tween80 emulsifier for later use;
each mixed solution: respectively taking 10, 6, 4, 15 and 15mL of 10mg/L oxadixyl solution, respectively adding the 10mg/L oxadixyl solution into 10, 15, 4 and 6mL of 10mg/L cymoxanil solution to prepare 10mg/L oxadixyl-cymoxanil 1:1, 2:5, 4:15, 15:4 and 5:2 solutions, and diluting the solution into 5, 1, 0.5, 0.1 and 0.05mg/L solutions by using sterile water containing 0.1 percent Tween80 emulsifier for standby;
control solution: 0.5mL DMF was added 95mL sterile water containing 0.1% Tween80 emulsifier.
4 test method
With reference to the biological standard method NY/T1156.3-2006, the plate-and-leaf method is used. Preparing sporangium suspension: selecting diseased leaves, washing sporangia of downy mildew on the back of the leaves with distilled water at 4 ℃ to prepare suspension (the concentration is controlled to be 1 multiplied by 105 to 1 multiplied by 107 sporangia per milliliter), and storing at 4 ℃ for later use.
Uniformly spraying the prepared liquid medicine on the back of the blade, naturally airing the liquid medicine, upwards treating the back of the blade, and discharging the blade into a moisturizing box according to the treatment mark. 24 hours after the drug treatment, 10. Mu.L of the prepared fresh sporangia suspension was inoculated on the back of the leaf. 4 drops were inoculated per leaf, 5 leaves per treatment, and the test was run with no drug-containing treatment as a blank. Covering a dish cover after inoculation, placing the dish cover in a manual climatic box, and culturing under the conditions of continuous illumination/darkness for 12 hours each day alternately, the temperature being 17-22 ℃ and the relative humidity being more than 90%.
5 data investigation and statistical analysis
5.1 investigation method
And measuring and recording the diameter of the lesion according to the disease condition of the blank control, and calculating the control effect (%).
Wherein: i represents the hypha growth inhibition rate; d (D) 0 Indicating the growth diameter of the blank colony; dt represents the growth diameter of the drug-treated colonies.
5.2 method for evaluating synergy
The synergy of the mixed medicines is evaluated according to a co-toxicity coefficient method (CTC) of Sun & Johnson (1960) by referring to a biological assay criterion NY/T1156.6-2006 in a pesticide room, namely CTC is less than or equal to 80 and is antagonistic, CTC is 80 and CTC is 120 and is additive, and CTC is more than or equal to 120 and is synergistic.
Drug combination Theory Toxicity Index (TTI) =toxicity index of agent a x percent (%) of agent a in the combination + percent (%)
5.3 statistical analysis of data
All experimental data were analyzed using DPS v9.50 statistical software. The hypha growth inhibition (%) was calculated from the test data, and the virulence regression equation, correlation coefficient (r) and EC50 (95% confidence limit) were calculated.
6 results analysis and discussion
6.1 evaluation of drug efficacy
The toxicity measurement results of the mixed combination of the oxadixyl and the cymoxanil with different proportions on the cucumber downy mildew are shown in table 1. As can be seen from Table 1, the synergistic effect of the mixture of oxadixyl and cymoxanil in the ratio of 1:1, 2:5, 4:15, 15:4 and 5:2 is shown for the cucumber downy mildew, the EC50 values of the synergistic effect are respectively 0.56, 0.49, 0.43, 0.75 and 0.71mg/L, and the co-toxicity coefficients of the synergistic effect of the mixture of the oxadixyl and cymoxanil in the ratio of 4:15 are respectively 139.44, 134.17, 147.17, 140.44 and 136.36.
TABLE 1 toxicity determination results of oxadixyl and cymoxanil on cucumber downy mildew
6.2 discussion and conclusion
Indoor biological test results show that the oxadixyl and cymoxanil are mixed according to the proportion of 1:1, 2:5, 4:15, 15:4 and 5:2, and the oxadixyl and cymoxanil have synergistic effects on cucumber downy mildew, wherein the synergistic effect is better according to the proportion of 4:15. Therefore, the optimal ratio of the oxadixyl to the cymoxanil can be seen as 4:15.
Application example three: example 1 field efficacy experiment for controlling cucumber downy mildew
The test is described in the pesticide registration field efficacy test quality management Specification (NY/T2885-2016) and in the pesticide field efficacy test criterion (one) part 26: bactericide for controlling cucumber downy mildew (GB/T17980.26-2000). The test process is strictly carried out according to a test scheme, and the report truly and accurately reflects the test result.
Test crop cucumber
Downy mildew of control object
1 test basic information
1.1 test name
The field efficacy test of the 38% oxadixyl and cymoxanil water dispersible granule on cucumber downy mildew.
1.2 purpose of test
The control effect, the applicable dosage and the safety of the 38% oxadixyl and cymoxanil water dispersible granule provided by the applicant on the cucumber downy mildew are clear, and the basis is provided for registering and popularizing test agents.
2 environmental and facility cultivation conditions
2.1 test position
New village city of Henan province.
2.2 test target conditions
Cucumber downy mildew (Fusarium graminearum Schw.)
2.3 testing crops, varieties and growth
The cucumber is 36 kinds of new excellent, the sowing time is 8 months and 9 days in 2020, the sowing mode is to dibble, the plant spacing is 25 cm, and the row spacing is 50 cm.
3 test design and arrangement
3.1 test amount and numbering
TABLE 2 test design of reagents for test
3.2 methods of administering drugs
3.2.1 periods of application and methods
The drug was co-administered 3 times, with three administrations 8 days apart. The first application time is 8 months and 28 days in 2020, and the cucumber growth period is in seedling stage; the second application time is 9 months and 5 days in 2020, and the cucumber growth period is in the early flowering period; the third application time is 9 months and 13 days in 2020, the cucumber growth period is in fruiting period, and spraying is carried out.
3.2.2 usage Capacity
The amount of the chemical solution sprayed per hectare was about 750 liters.
3.3 investigation method, time and times
3.3.1 investigation time and times
The disease number is not investigated for the sporadic onset of cucumber downy mildew before the first application (28 days of 8 months) and before the second application (5 days of 9 months), and the investigation is carried out 2 times before the third application (13 days of 9 months) and 8 days after the third application (21 days of 9 months).
3.3.2 investigation method
4 spots were randomly taken per cell, 2 plants were randomly investigated per spot, and all leaves of each plant were investigated and recorded according to the following grading method.
Grade 0, no disease spots;
stage 1: the area of the disease spots accounts for less than 5% of the whole leaf area;
stage 3, the area of the lesion accounts for 6% -10% of the whole leaf area;
stage 5, the area of the lesion accounts for 11% -25% of the whole leaf area;
7, the area of the lesion accounts for 26-50% of the whole leaf area;
stage 9: the area of the disease spots accounts for more than 50% of the whole leaf area.
3.3.3 method for calculating efficacy
Note that CK 0 -blank control zone disease index; PT 0-treatment area index.
4 results and analysis
Table 3 test results 1 of 38% oxadixyl and cymoxanil water dispersible granules for controlling cucumber downy mildew
The investigation result before the third application shows that the control effect of the water dispersible granule containing the effective components of the oxadixyl and cymoxanil is 81.78% when the water dispersible granule is treated with the effective components of 342 g/hectare, the control effect is best, and the control effect is obviously different from other treatments. The control effect of the water dispersible granule containing the oxadixyl and cymoxanil with the dosage of 285 g/hectare of the effective component of 38% is 76.02%, the control effect of the water dispersible granule containing the oxadixyl and cymoxanil with the dosage of 270 g/hectare of the effective component of the contrast medicament 20% is 71.75%, and the control effect of the water dispersible granule and the cymoxanil with the effective component of 270 g/hectare is not obvious. The control effect of the water dispersible granule containing the oxadixyl and cymoxanil is 67.46% when the water dispersible granule containing the cymoxanil is used for 228 g/hectare, and the control effect of the water dispersible granule containing the cymoxanil is 59.35% when the water dispersible granule containing the cymoxanil and cymoxanil is used for 360 g/hectare.
Table 4 test results 2 of 38% oxadixyl and cymoxanil water dispersible granules for controlling cucumber downy mildew
The investigation result 8 days after the third application shows that the control effect of the water dispersible granule containing the effective components of the oxadixyl and cymoxanil is 83.73% when the water dispersible granule is treated with the effective components of 342 g/hectare, the control effect is best, and the control effect is obviously different from other treatments. The control effects of the water dispersible granule containing the oxadixyl and cymoxanil with the effective component of 285 g/hectare and the water dispersible granule containing the effective component of 228 g/hectare are 80.03% and 70.17%, respectively, the control effect of the water dispersible granule containing the oxadixyl and cymoxanil with the effective component of 270 g/hectare with the effective component of 20% of the contrast agent is 76.36%, and the control effect of the water dispersible granule containing the oxadixyl and cymoxanil with the effective component of 20% of the contrast agent is 61.37%.
Application example four: example 2 efficacy test for controlling cucumber downy mildew
Specific experimental basis, experimental medicament and dosage, investigation method and calculation method refer to application example III.
1 test position
Taigu county, shanxi province.
2 test crop, variety and growth conditions
Cucumber, cultivar dell 50. The growth is good.
3 method of administering a drug
3.1 periods of application and methods
The test was co-administered 3 times, first at 29 days 7 and 29 months 2020, second at 5 days 8 and 2020, and third at 12 months 8 and 2020.
3.2 usage Capacity
The amount of the chemical solution sprayed per hectare was about 750 liters.
3.3 investigation time
First investigation: the medicine is applied for the first time in 7 months and 29 days in 2020, sporadic disease spots appear in the field, and the disease index is recorded as zero.
Second investigation: the prevention effect is investigated 7 days after the last drug administration of 8 months and 19 days in 2020, and the disease condition is recorded according to the grading standard.
4 results and analysis
Table 5 test results of 38% oxadixyl and cymoxanil water dispersible granules for controlling cucumber downy mildew
The test agent 38% oxadixyl and cymoxanil water dispersible granule of the example 2 is applied before or at the beginning of the onset of cucumber downy mildew, the application times are 3 times at intervals of 7-10 days, the dosage of the effective component dosage is 285-342 g/hectare (the dosage of the preparation is 50-60 g/mu), the test agent test dosage is safe for cucumber plants and melon strips.
Application example five: example 3 efficacy test for controlling cucumber downy mildew
Specific experimental basis, experimental medicament and dosage, investigation method and calculation method refer to application example III.
1 test position
Thailand City, shandong province.
2 test crop, variety and growth conditions
The cucumber is of the Jinchun No. four, is in the early stage of cucumber growth and has better growth condition when being applied.
3 method of administering a drug
3.1 periods of application and methods
The first application time is 7 months and 19 days in 2020; the second application time is 7 months and 26 days in 2020; the third administration time is 8 months and 2 days in 2020. And (5) spraying.
3.2 usage Capacity
The amount of the sprayed liquid medicine is about 900 liters per hectare.
3.3 investigation time
The total leaf number and the leaf number of each stage were investigated 4 times before administration, 7 days after 1 st administration, 7 days after 2 nd administration and 10 days after 3 rd administration, namely, 7 month 19 days in 2020, 26 days in 7 months, 2 days in 8 months and 12 days in 8 months.
4 results and analysis
Table 6 test results of 38% oxadixyl and cymoxanil water dispersible granules for controlling cucumber downy mildew
The test agent 38% oxadixyl and cymoxanil water dispersible granule of the embodiment 3 has better control effect on cucumber downy mildew, and the average control effect of the test agent 38% oxadixyl and cymoxanil water dispersible granule of the embodiment 1 (40 g/mu of preparation), 2 (50 g/mu of preparation) and 3 (60 g/mu of preparation) is found by analysis of variance and multiple comparison to be as follows: 67.75%, 74.52% and 78.11%, the average control of the control 20% oxadixyl suspension treatment 4 (90 g/mu formulation) and 20% cymoxanil suspension treatment 5 (120 g/mu formulation) were 68.46% and 71.79% in that order, with the average control at treatment 3 being highest. Treatment 1 and treatment 4 were not significantly different, and the other treatments were significantly different from one another (0.05 level).
7 days after the second application, the average control effects of the tested object 38% oxadixyl and cymoxanil water dispersible granule in treatment 1, treatment 2 and treatment 3 are as follows: 73.53%, 79.36% and 82.01%, the average control of the control 20% oxadixyl suspension treatment 4 and 20% cymoxanil suspension treatment 5 was 75.45% and 77.62% in that order, with the average control at treatment 3 being highest and differing significantly from the other treatments. Treatment 1 and treatment 4, treatment 5 and treatments 2, 4 differ but not significantly, and the other treatments differ significantly (0.05 level) from one another.
10 days after the third application, the average control effects of the tested object 38% oxadixyl and cymoxanil water dispersible granule in treatment 1, treatment 2 and treatment 3 are as follows: 78.06%, 84.06% and 87.32%, the average control of the control 20% oxadixyl suspension treatment 4 and 20% cymoxanil suspension treatment 5 were 80.16% and 82.09% in that order, with the average control at treatment 3 being highest and differing significantly from the other treatments. Treatment 4 differed from treatments 1, 5 but not significantly, and the other treatments differed significantly (0.05 level) from one another.
Application example six: example 4 efficacy test for controlling cucumber downy mildew
Specific experimental basis, experimental medicament and dosage, investigation method and calculation method refer to application example III.
1 test position
The Sichuan province is Chong Zhou, the city of Du.
2 test crop, variety and growth conditions
The cucumber is white cucumber and has a seedling stage.
3 method of administering a drug
3.1 periods of application and methods
The total application time is 3 times, the application time combined with the weather condition is respectively that the first application time is 2020 8 months 16 days, the second application time is 2020 8 months 23 days, and the third application time is 2020 8 months 30 days. And (5) spraying.
3.2 usage Capacity
The amount of the chemical solution sprayed per hectare was about 750 liters.
3.3 investigation time
Disease number was investigated before administration, and drug efficacy was investigated on 8 months, 16 days, 8 months, 23 days, 8 months, 30 days, 7 days after the first administration (8 months, 23 days) and 7 days after the last administration (9 months, 6 days), respectively, in 2020.
4 results and analysis
Table 7 test results of 38% oxadixyl and cymoxanil water dispersible granules for controlling cucumber downy mildew
As can be seen from Table 7, the test agent 38% oxadixyl and cymoxanil water dispersible granule of example 4 has better control effect on cucumber downy mildew, and as found by analysis of variance and multiple comparison, the effective component amounts of the 38% oxadixyl and cymoxanil water dispersible granule are respectively 71.27%, 75.40% and 83.67%, the effective component content of the control agent 20% oxadixyl suspending agent is 270g/hm2, and the average control effect of the control agent 20% cymoxanil suspending agent 360g/hm2 is respectively 68.14% and 79.22%. Statistical analysis results of the test data by adopting the Duncan new complex polar difference method show that: the average control effect difference between the 38% oxadixyl and cymoxanil water dispersible granule 228g/hm2 of the test agent and the 38% oxadixyl and cymoxanil water dispersible granule 285g/hm2 of the test agent, the 20% oxadixyl suspending agent 270g/hm2 of the control agent and the 20% cymoxanil suspending agent 360g/hm2 is not obvious, and the average control effect difference between the 38% oxadixyl and cymoxanil water dispersible granule 342g/hm2 of the test agent is obvious; the average prevention effect difference between the water dispersible granule of the oxadixyl and cymoxanil of the 38% of the test agent 285g/hm2 and the water dispersible granule of the oxadixyl and cymoxanil of the 38% of the test agent 342g/hm2, the suspension of the oxadixyl of the 20% of the control agent 270g/hm2 and the suspension of the cymoxanil of the 20% 360g/hm2 is not obvious; the average control effect difference between the test agent of 342g/hm2 of the oxadixyl and cymoxanil water dispersible granule and the control agent of 270g/hm2 of the oxadixyl and cymoxanil suspending agent of 20% is obvious, and the average control effect difference between the test agent of 360g/hm2 of the cymoxanil suspending agent of 20% is not obvious.
The foregoing is a further detailed description of the invention in connection with the preferred embodiments, and it is not intended that the invention be limited to the specific embodiments described. It will be apparent to those skilled in the art that several simple deductions or substitutions may be made without departing from the spirit of the invention, and these should be considered to be within the scope of the invention.
Claims (7)
1. The water dispersible granule containing the oxadixyl is characterized in that: the water dispersible granule comprises the effective active ingredients of oxadixyl and cymoxanil, wherein the weight ratio of the oxadixyl to the cymoxanil is 4:15;
the water dispersible granule contains oxadixyl, cymoxanil, a synergistic agent, a white carbon black mixture and an auxiliary agent;
the synergistic agent is a mixture of polyethoxy modified silane and polyethoxy modified fatty alcohol or alkoxy modified polysilicone, and the weight ratio of the synergistic agent to the white carbon black is 1:1-3:1;
the auxiliary agent is one or more selected from dispersing agent, wetting agent, binding agent, defoamer, pH regulator and filler.
2. The water dispersible granule according to claim 1, wherein: the total weight of the oxadixyl and cymoxanil in the water dispersible granule is 19% -76%.
3. The water dispersible granule according to claim 2, wherein: the total weight of the oxadixyl and cymoxanil in the water dispersible granule is 38%.
4. The water dispersible granule according to any one of claims 1 or 2, wherein: the water dispersible granule comprises the following components in percentage by weight: 4-60% of oxadixyl, 4-60% of cymoxanil, 3-20% of a mixture of a synergistic agent and white carbon black, 1-20% of a dispersing agent, 1-10% of a wetting agent, 1-20% of a binder, 0-3% of a defoaming agent, 0-4% of a pH regulator and 100% of a filler.
5. The water dispersible granule according to claim 4, wherein: the dispersing agent is one or more selected from methylene dinaphthyl sodium sulfonate, alkyl naphthalene sulfonate, EO-PO block polyether, styrene phenol polyoxyethylene ether phosphate, alkylphenol polyoxyethylene ether sulfonate, fatty alcohol polyoxyethylene ether phosphate and comb-shaped polycarboxylate;
the wetting agent is one or more selected from sodium dodecyl benzene sulfonate, sodium diisobutyl naphthalene sulfonate, sorbitan fatty acid ester, sodium sulfodocusate, alkylphenol formaldehyde resin polyoxyethylene ether, styrylphenol formaldehyde resin propylene oxide block polyether and alkyl glycoside;
the binder is one or more selected from water, polyvinylpyrrolidone and glucose;
the pH regulator is one of glacial acetic acid and citric acid;
the defoaming agent is selected from one of organic silicone and fatty alcohol;
the filler is selected from the group consisting of: white carbon black, calcined kaolin, potassium sulfate, diatomite, starch and urea.
6. Use of a water dispersible granule according to any one of claims 1 to 5, characterized in that: the water dispersible granule is used for preventing and controlling cucumber downy mildew.
7. Use according to claim 6, characterized in that: the water dispersible granule is used for preventing and treating cucumber downy mildew, and the dosage of the effective active ingredients is 228-342 g/hectare.
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