CN115282247A

CN115282247A - Traditional Chinese medicine for treating advanced cancer and preparation method thereof

Info

Publication number: CN115282247A
Application number: CN202111681047.5A
Authority: CN
Inventors: 杨杰
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-12-31
Filing date: 2021-12-31
Publication date: 2022-11-04

Abstract

The invention discloses a traditional Chinese medicine for treating advanced cancer and a preparation method thereof, wherein the traditional Chinese medicine is prepared from the following medicinal materials in parts by weight: 15-30 parts of potassium nitrate, 15-30 parts of radix curcumae, 15-30 parts of alum, 25-50 parts of fructus aurantii, 15-30 parts of prepared frankincense, 15-30 parts of prepared myrrh, 3-6 parts of liquorice, 120-140 parts of prepared nux vomica, 15-30 parts of rhizoma corydalis, 15-30 parts of circium japonicum, 15-30 parts of astragalus membranaceus and 15-30 parts of prepared sea buckthorn fruit. The preparation method comprises the following steps: preparing raw materials, stripping, forming, covering, drying, selecting pills and coating. The traditional Chinese medicine has reasonable compatibility of medicines, eliminates pathogenic factors and strengthens body resistance, is suitable for various cancers and precancerous lesions, and is particularly suitable for advanced cancers; compared with the common radiotherapy and chemotherapy, the traditional Chinese medicine composition has low treatment cost, no toxic reaction and no damage to normal cells, and relieves the treatment pain and economic burden of cancer patients.

Description

Traditional Chinese medicine for treating advanced cancer and preparation method thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine for treating advanced cancer and a preparation method thereof.

Background

In recent years, cancer has become a high-incidence chronic disease. Cancer is a generic term for all malignancies. The etiology and pathogenesis of the tumor in modern medicine are not clear at present, but the theory is that: the tumor is a new organism formed by local histiocyte hyperplasia caused by gene mutation of organism under the action of various tumorigenic factors. Modern medicine has many treatment methods for tumors, such as surgical treatment, interventional therapy, targeted therapy, immunotherapy, chemotherapy, radiotherapy and the like, mainly focuses on tumor tissues, focuses on solving the formed tumor masses, and can kill tumor cells, but normal tissue cells are damaged to different degrees at the same time, so that the survival period of a plurality of cancer patients is shortened due to toxic reactions (such as liver function damage, gastrointestinal dysfunction, leukopenia, anemia and the like). Modern medicine places less attention on the overall condition of a human body, and even if local tumors disappear, the internal environment for generating the tumors is not changed, so that the recurrence is easily caused. In addition, if the cancer patients are treated by western medicine, the annual cost of the cancer patients is basically more than 10 ten thousand yuan, which causes great economic burden to the cancer patients.

The traditional Chinese medicine emphasizes the whole function of human body when treating cancer, "treating the disease must meet the basic requirements", draws salary on the bottom of a kettle, eliminates the internal environment generating the cancer, recovers the normal functions of qi and blood of viscera, harmonizes yin and yang, and achieves the purposes of treating and preventing relapse. The understanding of the traditional Chinese medicine on the cause of tumor diseases is mainly divided into two aspects of internal cause and external cause: internal causes refer to deficiency of qi and blood, excessive seven emotions and dysfunction of qi and blood of viscera; the external factors are the invasion of pathogenic toxin, accumulation in meridians and viscera, which causes qi stagnation, blood stasis, phlegm coagulation, food stagnation, etc. The chronic qi diseases include lump, mass accumulation, and abdominal mass (such as breast cancer, lung cancer, and gastric cancer); qi stagnation often causes blood stasis, qi and blood stasis, and lumps can be formed after long-term accumulation (such as abdominal cavity tumor, genital organ tumor, etc.); dysfunction of the lung, spleen and kidney, and the addition of cold, heat, qi, fire and other factors, which can cause the body fluids not to be normally transported and run, phlegm is gathered and produced, phlegm is carried along with qi, phlegm is in the lung, cough and dyspnea with profuse sputum (such as lung cancer), phlegm and saliva are vomited in the stomach, diet is difficult to enter (such as cardia cancer and stomach cancer), and phlegm nodule, scrofula, goiter and the like (such as malignant lymphoma, lymph node metastasis and the like) are formed when the phlegm flows through the channels and collaterals and subcutaneous tissues; eating disorder impairs the spleen and stomach, which may lead to food stagnation, accumulation of food, phlegm, dampness and accumulation of phlegm and blood stasis (such as digestive tract tumor).

Therefore, for the treatment of malignant tumor, on one hand, effective tumor-inhibiting drugs such as traditional Chinese medicines for promoting blood circulation to remove blood stasis, eliminating phlegm and resolving masses, clearing heat and detoxicating, and inducing diuresis to attack and treat the malignant tumor should be selected to actively attack cancer (i.e., eliminate pathogenic factors), on the other hand, the anticancer capability of the host body should be enhanced, and tonifying (i.e., strengthening body resistance) is applied, and the combination of strengthening body resistance and eliminating pathogenic factors is performed, so that the healthy qi is not damaged by eliminating pathogenic factors, and the healthy qi is strengthened without assisting pathogenic factors, and then good effects can be obtained.

Although some traditional Chinese medicines for treating malignant tumors are disclosed in the prior art, certain effect is achieved in clinical practice, but the overall curative effect is unsatisfactory because: eliminating pathogenic factors and damaging healthy qi, i.e. many of the currently used anticancer drugs cause cancer cell death and damage to normal cells due to their serious toxic effects. Therefore, the development of a drug which can resist tumor, does not damage normal cells, can enhance the immune function of the organism and promote rehabilitation is a great problem to be solved at present.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provides a traditional Chinese medicine for treating advanced cancer and a preparation method thereof.

The invention is implemented by the following technical scheme:

a traditional Chinese medicine for treating advanced cancer is prepared from the following medicinal materials in parts by weight: 15-30 parts of potassium nitrate, 15-30 parts of radix curcumae, 15-30 parts of alum, 25-50 parts of fructus aurantii, 15-30 parts of prepared frankincense, 15-30 parts of prepared myrrh, 3-6 parts of liquorice, 120-140 parts of prepared nux vomica, 15-30 parts of rhizoma corydalis, 15-30 parts of circium japonicum, 15-30 parts of astragalus membranaceus and 15-30 parts of prepared sea buckthorn fruit.

Among them, preferred are: 20 parts of potassium nitrate, 20 parts of radix curcumae, 20 parts of alum, 30 parts of fructus aurantii, 20 parts of prepared frankincense, 20 parts of prepared myrrh, 5 parts of liquorice, 120 parts of prepared nux vomica, 20 parts of rhizoma corydalis, 15 parts of Japanese thistle herb, 20 parts of astragalus and 20 parts of prepared sea buckthorn fruit.

Optionally, the Chinese medicinal preparation can be powder, tablet, pill, granule, capsule, suppository and injection.

Optionally, the preparation method of the sea buckthorn berries comprises the following steps: adding sand into an iron pan, parching at 180-200 deg.C, adding clean fructus Hippophae, continuously turning, scalding until the surface of fructus Hippophae is brown or dark brown, taking out, sieving to remove sand, quickly rinsing fructus Hippophae with water, and air drying.

The preparation method of the traditional Chinese medicine preparation is as follows:

(1) Preparation of raw materials: weighing, mixing and crushing the medicinal materials according to the parts by weight, and sieving the medicinal materials by a 100-mesh sieve to obtain medicinal powder;

(2) Stripping: spraying water into the pill making pot until the inner wall of the pill making pot is in a wet state, spreading a small amount of medicinal powder into the pill making pot to ensure that the medicinal powder just covers the bottom wall of the pill making pot, rotating the pill making pot, brushing the wall of the pot to attach the powder particles, spraying water and dusting, repeatedly circulating for many times to gradually enlarge the powder particles until spherical particles with the diameter of 1-2mm are formed, and sieving the particles with a sieve of 10 meshes to 24 meshes to obtain pill molds;

(3) Molding: repeating the step (2) to gradually increase the diameter of the pills to 3-4mm;

(4) And (3) covering: adding water into the rest medicinal powder and the waste pills sieved in the step (2) to prepare a medicinal liquid, uniformly scattering the medicinal liquid on the pills obtained in the step (3), and continuously rolling the medicinal liquid in a pill making pot to ensure that the medicinal liquid reaches the size standard, the surface is smooth and compact and the color is uniform of finished pills, and then taking out the finished pills;

(5) And (3) drying: drying the covered pills in time at a drying temperature of less than 80 ℃ until the water content is less than or equal to 9%;

(6) Selecting pills: selecting pills through a drum sieve and a pill detector to ensure that the pills are round and uniform in size;

(7) Coating: and (4) coating, polishing and drying the pills obtained in the step (6). Optionally, the weight of the powder used in the drawing step is 12.5% -25% of the total powder weight.

Optionally, the rotation speed of the pill making pan is controlled at 40-45r/min.

Optionally, the drying method in step (5) is microwave drying. The microwave drying has high drying speed, uniform internal and external drying humidity of the dried pills, puffing effect for facilitating dissolution, and low-temperature sterilization effect.

Optionally, the material used for coating in step (7) is licorice coating, and the polishing time is 2-3min. The liquorice can play the drug effect firstly, and can also protect the pill and improve the appearance.

The invention is made according to the following mechanism: according to the pathogenesis that the tumor is formed by 'deficiency of vital qi, exuberance of pathogenic factors and blood stasis', the invention adopts natural medicines of potassium nitrate, radix curcumae, alum and fructus aurantii as monarch drugs, and the potassium nitrate can break the tumor, eliminate hard mass, eliminate sore, remove arthralgia, activate blood and remove stasis, dissolve calculi, promote diuresis and relieve pain; radix Curcumae has effects in promoting blood circulation, relieving pain, promoting qi circulation, resolving stagnation, promoting bile flow, and eliminating jaundice; alumen has effects in relieving arthralgia, resolving carbuncle, stopping bleeding, relieving diarrhea, and eliminating phlegm; the fructus Aurantii can break the stagnation and relieve stuffiness, regulate qi and relieve chest stuffiness, invigorate stomach and eliminate stagnation; the monarch drugs strengthen each other and play the roles of resolving hard mass, breaking food stagnation, eliminating carbuncle, promoting blood circulation, removing blood stasis and relieving pain together. The four medicines of frankincense, myrrh, semen strychni preparata and rhizoma corydalis are used as ministerial medicines, and the frankincense and the myrrh are compatible together, so that the effect of activating blood and relieving pain can be enhanced; nux vomica is added to assist the monarch drug in dredging collaterals, relieving distension and pain, reducing swelling, resolving masses, removing stasis and promoting granulation; the rhizoma corydalis is matched with the monarch drug to promote blood circulation, remove blood stasis, promote qi circulation and relieve pain. The Japanese thistle herb and the astragalus root and the prepared sea buckthorn fruit are taken as adjuvant drugs, and the Japanese thistle herb can cool blood, relieve pain, remove stasis, eliminate carbuncle, tonify qi and calm nerves; radix astragali has effects in invigorating qi, invigorating yang, replenishing kidney essence, invigorating spleen, invigorating defensive qi, consolidating superficial resistance, promoting granulation, inducing diuresis, and relieving swelling; the fructus Hippophae has effects in promoting blood circulation, removing blood stasis, eliminating phlegm, relieving chest stuffiness, promoting digestion, removing food stagnation, promoting fluid production, quenching thirst, clearing away heat, and relieving diarrhea; the three herbs are combined to tonify deficiency and promote tissue regeneration, and are indicated for weakness after illness, carbuncle, sore and ulceration, unhealed wound for a long time, etc. The liquorice is used as a guiding drug, has the purpose of harmonizing the drugs, and also can tonify spleen and qi, relieve spasm and pain and the like. The medicines are compatible, so that the traditional Chinese medicine composition can dredge collaterals, relieve depression, nourish kidney, tonify spleen, invigorate stomach, consolidate constitution, regulate qi, relieve chest stuffiness, tonify qi, raise yang, remove necrotic tissue, promote granulation, improve the immune function of an organism, improve the internal environment of the organism, stimulate the self-healing capability of the organism and enhance the anticancer capability of the organism, namely 'strengthening the body resistance'; but also can soften hard masses, break food retention, relieve stuffiness, activate blood circulation, remove blood stasis, relieve pain, clear away heat and toxic materials, expel pus, and initiate the reversion or death of cancer cells, namely 'eliminate pathogenic factors', eliminate pathogenic factors without damaging healthy qi, and strengthen healthy qi without assisting pathogenic factors.

The pharmacological effects of the components of the invention are as follows:

1. and (3) nitrate: is a natural mineral, mainly contains potassium nitrate, and has bitter taste and cold property. The functional indications are as follows: resolving food stagnation, resolving hard mass, eliminating sore, relieving oppression, promoting blood circulation, removing blood stasis, inducing diuresis, relieving swelling, removing calculus, inducing diuresis, and relieving pain. It is used to treat severe headache, chest pain, lumbago, abdominal pain, redness, swelling and pain of eyes, nebula, throat impediment, dysentery, stranguria, dorsal furuncle, urticaria, etc.

2. Turmeric root-tuber: is dried root tuber of Curcuma wenyujin Y.H.Chen et C.Ling, curcuma longa L.E., curcuma kwangsiensis C.kwangsiensis S.G.Lee et C.F.Liang or Curcuma zedoaria C.phaeocaulis Val. Pungent, bitter and cold in nature; it enters liver, gallbladder, heart and lung meridians. The efficacy is mainly as follows: promoting blood circulation to arrest pain, promoting qi circulation to relieve depression, clearing away heart-fire, cooling blood, promoting bile flow, and eliminating jaundice (the herbal essentials: "moving qi, relieving depression, dispelling blood, removing blood stasis, cooling heart heat, and dispelling liver depression"). It is indicated for qi stagnation and blood stasis pain, coma due to febrile disease, epilepsy, phlegm block, hematemesis, epistaxis, retrograde menstruation, hematuria, bloody stranguria, jaundice due to damp-heat in liver and gallbladder, and cholelithiasis. The pharmacological action is as follows: radix Curcumae has effects of protecting liver cell, promoting liver cell regeneration, removing fat, and inhibiting liver cell fibrosis, and can resist hepatotoxic pathological changes. Curcumin and volatile oil can promote bile secretion and excretion, and reduce urinary urobilinogen; the decoction can stimulate gastric acid and duodenal secretion. The water decoction can reduce whole blood viscosity, inhibit platelet aggregation, and the alcohol extract can reduce plasma fibrin content. The decoction and volatile oil have inhibitory effect on various dermatophytes, and radix Curcumae has inhibitory effect on various bacteria, especially on gram-negative bacteria. Yu jin also has anti-inflammatory and analgesic effects. In addition, radix Curcumae also has effect of resisting early pregnancy.

3. Alum: is prepared by processing and refining sulfate mineral alunite. Mainly aqueous aluminium potassium sulfate [ KAl (SO) ₄ ) ₂ ·12H ₂ O ]. Sour and astringent taste, cold nature and slight toxicity; it enters lung, spleen, liver, large intestine and bladder meridians. The efficacy is mainly as follows: it can be used topically for removing toxic substance, killing parasite, eliminating dampness, and relieving itching; it is used internally to relieve arthralgia, cure abscess, stop bleeding, check diarrhea and resolve phlegm. It can be used for treating apoplexy, epilepsy, pharyngitis, scabies, tinea, eczema, carbuncle, toxic swelling, scald due to water or fire, aphtha of the mouth and tongue, epidemic conjunctivitis, purulent discharge in the nasal passage, skin ulcer, hemorrhoid pain, metrorrhagia, epistaxis, traumatic hemorrhage, chronic diarrhea, dysentery, leukorrhagia, pudendal pruritus, rectocele, and metroptosis. For alum stone, tu Li Feng in compendiumFor phlegm and saliva, it is sour, bitter, gushing and discharging; for various bloody pains, rectocele, profuse yin and sores and ulcers, it is also sour and astringent; for phlegm-fluid retention, diarrhea, metrorrhagia and metrostaxis, it is collected and dried; for sore throat, abscess and deep rooted carbuncle, snake and insect sting, it is also used to remove toxicity. ) The pharmacological action is as follows: has inhibitory effect on Staphylococcus aureus and Proteus (test tube method). Has obvious inhibiting effect on Escherichia coli, pseudomonas aeruginosa, bacillus anthracis, bacillus dysenteriae (Freund, shigella), salmonella typhi, bacillus paratyphi, proteus, staphylococcus, candida albicans, etc. (paper dish, plate method); has the strongest effect on green streptococcus, hemolytic streptococcus, pneumococcus and diphtheria bacillus; has secondary effect on Brucella bovis, bordetella pertussis and meningococcus, and has no effect on influenza bacillus (paper sheet method). The high-concentration alum solution also has inhibitory effect on human type (H37 RV) and bovine type tubercle bacillus. It can be used for stopping bleeding by placing alum stick or powder directly on bleeding point, such as nasal hemorrhage by placing alum solution saturated with cotton ball into nostril. The alum is ground into soaking water, and the foot is soaked for 2 times every week according to the proportion of 1.

4. Fructus aurantii: is dried immature fruit of Citrus aurantium L.of Rutaceae and its cultivars. Bitter, pungent and sour in flavor, warm in nature and entering spleen and stomach meridians. The functional indications are as follows: break qi and resolve phlegm, break the stagnation and disperse the stuffiness, regulate qi and relieve chest stuffiness, eliminate stagnation and invigorate the stomach, and relieve stagnation and remove obstruction. It can be used for treating qi stagnation in chest and hypochondrium, hypochondriac distention, pain, indigestion, phlegm and fluid retention, chest fullness, belching, vomiting, diarrhea, gastric prolapse, rectocele, and uterine prolapse.

5. Preparing frankincense: is resin exuded from bark of Boswellia carterii Birdw of Burseraceae and Boswellia bhaw-dajiana Birdw of the same genus. Is divided into the frankincense of soma and the frankincense of Russia, and each kind of frankincense is divided into frankincense bead and original frankincense. Pungent and bitter taste, slightly warm in nature; enter heart, liver and spleen meridians. The efficacy is mainly as follows: regulating qi and removing toxic substances, promoting blood circulation and relieving pain, and removing superficial infection and toxic substances (gang mu). For stagnation of qi and blood, pain in the heart and abdomen, carbuncle, sore, swelling and toxin, traumatic injury, dysmenorrhea, postpartum blood stasis and stabbing pain, it can treat all sores and eliminate the interior (Ben Cao Shi Yi).

Vinegar milk gum: taking clean Olibanum, placing in a properly preheated frying container, frying with slow fire until smoking, spraying quantitative edible vinegar when the surface is slightly melted, frying until the surface shows glossy oil, quickly taking out, spreading and cooling. Every 100kg of Olibanum is mixed with 10kg of edible vinegar. Vinegar Olibanum has effects of promoting blood circulation, relieving pain, astringing, promoting granulation, relieving irritation, and is convenient for administration, easy for pulverizing, and can correct odor and flavor.

6. Preparing myrrh: is dried resin of Commiphora myrrha Engl. Or Commiphora mo1mol Engl. Of Candidae. Is divided into natural myrrh and colloid myrrh. Pungent, bitter and neutral in flavor; it enters heart, liver and spleen meridians. The efficacy is mainly indicated, and the prepared myrrh has the efficacy of promoting blood circulation, relieving pain, eliminating swelling and promoting granulation. It is used for treating traumatic injury, swelling and pain due to blood stasis, gastralgia due to blood stasis, amenorrhea, dysmenorrhea, carbuncle, cellulitis, swelling and pain, sore, and rheumatalgia. Myrrh and frankincense have similar effects, and are often combined for clinical use, so that they are contraindicated in pregnancy.

Vinegar myrrh: taking the medicinal blocks, parching with slow fire in a parching container with moderate preheating, spraying quantitative edible vinegar when the surface is slightly melted, parching until the surface shows oil and luster, quickly taking out, spreading and cooling. Edible vinegar 10kg per 100kg of Myrrha. The vinegar processed myrrh can enhance the effects of promoting blood circulation, relieving pain, astringing and promoting granulation, relieve irritation, is convenient to take, is easy to crush, and can correct odor and flavor.

7. Licorice root: is dried root and rhizome of Glycyrrhiza uralensis Fisch, glycyrrhiza inflata Bat, or Glycyrrhiza glabra L. Neutral in nature and sweet in flavor, it enters twelve meridians. The efficacy is mainly as follows: detoxicating, eliminating phlegm, relieving pain, relieving spasm, and resisting cancer. The liquorice tonifies the spleen and the qi, nourishes the cough and moistens the lung, relieves urgency and detoxifies and harmonizes a plurality of medicines. Clinical applications are divided into unprocessed and honey-processed. Unprocessed is mainly used for treating swollen sore throat, carbuncle, cellulitis, sore and ulcer, gastrointestinal ulcer, drug toxicity removal, food poisoning and the like; stir-baked with honey is mainly used for treating hypofunction of spleen and stomach, loose stool, weakness, fever, cough, palpitation and the like.

The pharmacological action is as follows:

7.1. acid resistance

Licorice root has the similar effect of adrenocortical hormone. Has inhibitory effect on hyperacidity caused by histamine; it also has antacid and spasmodic effects on smooth muscle of stomach and intestine.

7.2. Antitussive

Licoflavone, glycyrrhiza extract and glycyrrhetinic acid have obvious cough relieving effect; the phlegm eliminating effect is also obvious, and the action strength is glycyrrhizic acid, licoflavone and liquorice extract.

7.3. Anti-inflammatory and antiallergic

The Glycyrrhrizae radix has antiinflammatory and antiallergic effects, and can protect inflamed throat and trachea mucosa. The glycyrrhiza extract and glycyrrhizic acid have detoxifying effect similar to that of glucuronic acid on certain toxicants.

7.4. Balancing hormones in the female body

Licorice is commonly used for treating symptoms accompanying menopause because it contains liquiritigenin, a hormone-like compound that helps to balance the hormone content in women.

7.5. Preventing and treating tumor

The hypochlorous acid contained in Glycyrrhrizae radix can block carcinogen from inducing tumor growth.

Contraindicated people: it is contraindicated for damp obstruction, nausea, vomiting and edema. The method is suitable for people: is suitable for patients with gastric ulcer, duodenal ulcer, neurasthenia, bronchial asthma, and thrombophlebitis.

8. Preparing nux vomica: is dried mature seed of Strychnos nux-vomica L. Bitter and warm taste, cold nature, and strong toxicity (detoxified by preparation); it enters liver and spleen meridians. The functional indications are as follows: dredging collaterals, relieving pain, relieving swelling, resolving hard mass, removing blood stasis, promoting granulation, relieving inflammation, resisting bacteria, refreshing brain, invigorating stomach, activating qi-flowing, removing toxic substance, and cooling blood. It can be used for treating mammary gland lump, carbuncle, sore, swelling and pain due to blood stasis, sore throat, lump, cancer, arthralgia due to wind-cold-dampness, nerve paralysis, myasthenia gravis, poliomyelitis, anorexia, abdominal distention, and constipation.

9. Rhizoma corydalis and corydalis are also called corydalis tuber and corydalis tuber, which are perennial herb plants of corydalis of Papaveraceae, and are commonly called Zhejiang eight flavors together with white atractylodes rhizome, peony, fritillaria and the like, which are bulk common traditional Chinese medicines. Rhizoma corydalis is warm in nature, pungent and bitter in flavor, enters heart, spleen, liver and lung, is a wonderful product for activating blood circulation to dissipate blood stasis, promoting qi circulation to relieve pain, and is especially known for its action of relieving pain. Li Shizhen induces that rhizoma corydalis has four main effects of promoting blood circulation, regulating qi, relieving pain and removing urine in Ben Cao gang mu, and Chong rhizoma corydalis has the functions of promoting qi stagnation in blood and qi stagnation in blood, so it is specially used for treating pain in upper and lower parts of the body.

10. Herba seu radix Cirsii Japonici: is dried aerial part of Cirsium japonicum Fisch. Sweet and bitter taste and cool nature; it enters heart and liver meridians. The functional indications are as follows: cool blood to stop bleeding, dispel stasis to cure abscess, tonify qi to calm mind. It is used to treat epistaxis, hematemesis, hematuria, hematochezia, metrorrhagia, leukorrhagia, traumatic hemorrhage, carbuncle, swelling, sore, and asthenia after illness.

11. Astragalus root: is dried root of Astragalus membranaceus (Fisch.) bge of Leguminosae family such as Astragalus membranaceus (Fisch.) bge. Var. Mongholicus (bge.) Hsiao or Astragalus membranaceus (Fisch.) bge. Sweet in flavor and slightly warm in nature; it enters lung, spleen, liver and kidney meridians. The functional indications are as follows: nourishing and strengthening body, invigorating qi and yang, nourishing kidney and spleen, consolidating superficial resistance and arresting sweating, promoting pus discharge, eliminating swelling and promoting granulation, protecting liver and promoting urination, resisting aging and stress, lowering blood pressure, enhancing organism immunity, and resisting bacteria. The medicine has been used for more than 2000 years so far, and is used for treating carbuncle, sore and ulcer, unhealed for a long time, various cancers and the like.

12. Preparing sea buckthorn fruits: is fruit of Hippophae rhamnoides (Hippophae rhamnoides L.) belonging to Hippophae of Elaeagnaceae, also called Hippophae Rhamnoides and Hippophae Rhamnoides. Sour, astringent and warm in nature. The functional indications are as follows: promoting blood circulation, removing blood stasis, dissipating phlegm, relieving chest stuffiness, promoting digestion, resolving stagnation, promoting fluid production, quenching thirst, clearing heat and relieving diarrhea. It is indicated for traumatic injuries with blood stasis, amenorrhea due to blood stasis, lung abscess, cough with excessive phlegm, stomach ache, dyspepsia, enteritis and dysentery, high fever and yin impairment. The flavone in fructus Hippophae can increase serum complement level, enhance macrophage function, and supplement nutrition and improve disease resistance. The seabuckthorn oil contains 206 active substances beneficial to human bodies, wherein 46 bioactive substances comprise a large amount of vitamin E, vitamin A, brass and the like, has special pharmacological properties of resisting fatigue, enhancing the vitality of the body, resisting cancer and the like, protects and accelerates the repair of gastric mucosa, increases intestinal bifidobacteria, reduces plasma cholesterol, prevents and treats hyperlipidemia and atherosclerosis, and has the effect of promoting wound healing.

Compared with the prior art, the invention has the following beneficial effects:

1. the traditional Chinese medicine of the invention has reasonable compatibility, takes the functions of eliminating pathogenic factors and strengthening body resistance into consideration, and the eliminating pathogenic factors directly act on the focus of infection, so that the growth of tumor is inhibited and eliminated; the aim of strengthening the body resistance is to activate the self-healing power by regulating the autoimmune function so as to achieve the aim of resisting cancer; is suitable for various early, middle and late stage malignant tumors, precancerous lesion, nodule, and arthralgia due to wind-cold-dampness, and is mainly used for treating symptoms such as cancerous fever pain, hydrothorax ascites, cough, asthma, short breath, body membrane yellow stain, abdominal distention, diarrhea, and rheumatalgia; compared with the common radiotherapy and chemotherapy, the traditional Chinese medicine composition has no toxic reaction, has no damage to normal cells, and relieves the treatment pain of cancer patients;

2. the traditional Chinese medicine has good pain relieving effect on patients with advanced cancer, wherein the frankincense and the myrrh can promote blood circulation to relieve pain, the nux vomica can dredge collaterals to relieve pain, and the radix curcumae can promote blood circulation, resist inflammation and relieve pain.

3. The traditional Chinese medicine raw materials in the formula of the invention have low cost and wide sources, the treatment cost is only one fifth of the radiotherapy and chemotherapy cost of common cancer patients, and the economic burden of the cancer patients is reduced;

4. the seabuckthorn fruits are prepared into the prepared seabuckthorn fruits according to the method, the seabuckthorn fruits have moderate viscosity while exerting the drug effect, auxiliary materials are not required to be added during the pill preparation, and the administration dosage is reduced;

5. the anti-cancer pill prepared by the method has simple production equipment and is suitable for popularization and use; the prepared pill is easy to dissolve and absorb in vivo.

Detailed Description

The present invention is further illustrated by the following examples, but the scope of the present invention is not limited by the examples.

Example 1

A traditional Chinese medicine 'Xiaopi antalgic pill' for treating advanced cancer is prepared from the following medicinal materials in parts by weight: 2kg of potassium nitrate, 2kg of radix curcumae, 2kg of alum, 3kg of fructus aurantii, 2kg of prepared frankincense, 2kg of prepared myrrh, 0.5kg of liquorice, 12kg of prepared nux vomica, 1.5kg of rhizoma corydalis, 1.5kg of circium japonicum, 2kg of astragalus mongholicus and 2kg of prepared sea buckthorn fruits.

The preparation method of semen Strychni in the formula adopts the method recorded in pharmacopoeia of the people's republic of China (2015 edition), namely putting sand into a pot, parching with strong fire, adding clean semen Strychni, continuously stirring, scalding until the semen Strychni is swollen and appears dark brown or dark brown, taking out, sieving to remove sand, and cooling for use.

The preparation method of the seabuckthorn fruit in the formula comprises the following steps: putting sand into an iron pan, parching at 180-200 deg.C, adding clean fructus Hippophae, stirring, scalding until the surface of fructus Hippophae is brown or dark brown, taking out, sieving to remove sand, quickly rinsing fructus Hippophae, and air drying.

The preparation method comprises the following steps:

(1) Preparation of raw materials: weighing the medicinal materials according to parts by weight, mixing, crushing, and sieving with a 100-mesh sieve to obtain medicinal powder;

(2) Stripping: spraying water into the pill making pot until the inner wall of the pill making pot is in a wet state, spreading a small amount of medicinal powder into the pill making pot to ensure that the medicinal powder just covers the bottom wall of the pill making pot, rotating the pill making pot, controlling the rotating speed of the pill making pot at 42r/min, brushing powder particles attached to the pot wall, spraying water and scattering powder, repeatedly circulating for multiple times to gradually enlarge the powder particles until spherical particles with the diameter of 1-2mm are made, and screening the particles with a sieve of 10 meshes to 24 meshes to obtain a pill mold;

(5) And (3) drying: microwave drying the coated pills in time to make the water content less than or equal to 9%; the drying speed of the microwave drying is high, so that the inside and outside humidity of the dried pill is uniform, the puffing effect is generated, the dissolution is facilitated, and the low-temperature sterilization effect is achieved.

(7) Coating: and (4) coating the pills obtained in the step (6) with a liquorice coating, polishing for 2-3min, and drying to obtain the finished product. The licorice can not only exert the drug effect, but also protect the pill and improve the appearance.

Example 2

A traditional Chinese medicine 'Xiaopi Zhentong Wan' for treating advanced cancer is prepared from the following medicinal materials in parts by weight: 1.5kg of potassium nitrate, 3kg of radix curcumae, 1.5kg of alum, 5kg of fructus aurantii, 1.5kg of prepared frankincense, 3kg of prepared myrrh, 0.3kg of liquorice, 13kg of prepared nux vomica, 3kg of rhizoma corydalis, 3kg of Japanese thistle herb, 1.5kg of astragalus membranaceus and 3kg of prepared sea buckthorn fruit.

The preparation method comprises the following steps:

(2) Stripping: spraying water into the pill making pot until the inner wall of the pill making pot is in a wet state, spreading a small amount of medicinal powder into the pill making pot to ensure that the medicinal powder just covers the bottom wall of the pill making pot, rotating the pill making pot, controlling the rotating speed of the pill making pot at 45r/min, brushing powder particles attached to the pot wall, spraying water and scattering powder, repeatedly circulating for multiple times to gradually enlarge the powder particles until spherical particles with the diameter of 1-2mm are made, and screening the particles with a sieve of 10 meshes to 24 meshes to obtain a pill mold;

(4) And (3) covering: adding water into the rest medicinal powder and the waste pills sieved in the step (2) to prepare a medicinal liquid, uniformly scattering the medicinal liquid on the pills obtained in the step (3), and continuously rolling the medicinal liquid in a pill making pot to ensure that the medicinal liquid reaches the size standard, the surface is smooth and clean, the density and the color of finished pills are uniform, and then taking out the finished pills;

(5) And (3) drying: microwave drying the coated pills to make the water content less than or equal to 9%;

(7) Coating: and (4) coating the pills obtained in the step (6) with a liquorice coating, polishing for 2-3min, and drying to obtain the finished product.

Example 3

A Chinese medicinal preparation for the late stage of cancer, XIAOPIANZHENTONG pill, is prepared from the following medicinal materials in parts by weight: 3kg of potassium nitrate, 1.5kg of radix curcumae, 3kg of alum, 2.5kg of fructus aurantii, 3kg of prepared frankincense, 1.5kg of prepared myrrh, 0.6kg of liquorice, 14kg of prepared nux vomica, 2kg of rhizoma corydalis, 2kg of Japanese thistle herb, 3kg of radix astragali and 1.5kg of prepared sea buckthorn fruit.

The preparation method comprises the following steps:

(2) Stripping: spraying water into the pill making pot until the inner wall of the pill making pot is in a wet state, spreading a small amount of the medicinal powder into the pill making pot to ensure that the medicinal powder just covers the bottom wall of the pill making pot, rotating the pill making pot, controlling the rotating speed of the pill making pot at 40r/min, brushing the wall of the pot to adhere to powder particles, spraying water and scattering the powder, repeatedly circulating for many times to gradually increase the powder particles until spherical particles with the diameter of 1-2mm are made, and sieving the particles with a sieve of 10 meshes to 24 meshes to obtain a pill mold;

The invention discloses a usage and dosage of a disintegrating mass and relieving pain pill: the medicine is taken with warm boiled water for 1 treatment course 30 days, and generally continuously taken for 6 to 8 treatment courses, wherein the medicine is taken 1 to 2 g each time and 2 to 3 times a day according to the condition of different patients. More treatment courses are needed, and the treatment courses are separated by 2-3 days; after the symptoms and physical signs completely disappear, the treatment is carried out: the medicine is taken for 1 course every half year, and after 5 and 6 courses, the medicine is taken for 1-2 courses every year for consolidation treatment, and whether the medicine is taken or not is determined according to specific disease conditions. Generally, the medicine can be stopped after 5 years of survival.

Clinical observation 100 patients diagnosed with cancer in hospitals, including liver cancer, intestinal cancer, breast cancer, brain tumor, prostate cancer, lung cancer, uterine cancer, stomach cancer, lymph cancer, etc., were swallowed with the "Xiaopi antalgic pill" of the present invention with the guiding decoction.

The curative effect standard is as follows:

and (3) healing: clinical symptoms gradually improve until disappear, cancer tissues disappear or change into benign through laboratory examination, the indexes of tumor markers are basically normal, and the tumor marker gradually recovers after two years of survival without relapse.

Improvement: clinical symptoms are relieved, the laboratory checks that the cancer tissues stop diffusing or slow down growing, the indexes of the tumor markers are improved, and the tumor markers continue to survive for more than two years.

And (4) invalidation: clinical symptoms are not obviously improved or continuously aggravated, the laboratory checks that cancer tissues continue to spread or grow, the indexes of tumor markers are not improved, and the cancer tissues die within 1 year.

The treatment results are as follows:

after the 'Xiaopi antalgic pill' is taken, 68 cases are cured, 30 cases are improved, 2 cases are not effective, and the total effective rate is 98%. The basic conditions of spirit, appetite and the like of a patient are generally changed after the patient generally takes the medicine for 1-2 weeks, pain and edema are relieved, the appetite is gradually recovered, and the body temperature is recovered to be normal; after taking the medicine for 1 course of treatment, the symptoms are mostly relieved, the lumps are reduced, the disease is relieved day by day, and the blood pressure and the hemogram are improved; along with the progress of the treatment course, the weight rises, the constitution is improved day by day, and the daily housework activities can be treated; the patient keeps taking for 6-8 courses of treatment, the disease condition is generally improved, and part of the disease is cured; the cure rate can be improved after the medicine is taken for 12 courses of treatment.

The following are some typical cases of the clinical treatment of the traditional Chinese medicine of the invention:

case one: hongzao, male, 26 years old, xinhuacun people in the grass sea town, heqing county. "brain tumors" were treated in 1997, 12 months and 9 days. The right-side facial numbness, facial distortion and salivation, dizziness and hearing loss caused by no obvious inducement before 4 years, and the local diagnosis is facial paralysis, and the multi-aspect treatment is ineffective. In 1994, symptoms worsened progressively, with lateral bending during walking. The sixty hospital CT (# 2629) report of the liberated military on 1/20 d 1997 shows: "(1) ependymoma, (2) medulloblastoma"; the reports from Kunming general Hospital CT (# 38155) in the 3/4/1997 army district: "four ventricle occupancy lesions (considering gliomas)". After a course of treatment of chemotherapy and radiotherapy in the Hongqiao hospital of Yunnan province, the symptoms are relieved once. The symptoms of recent half year are recurrent and progressive aggravated, the right eye is painful and lacrimation, blurred vision and the muscle strength of the upper and lower limbs is reduced. The Chinese medicine 'Xiaopi antalgic pill' of the invention is taken 4 months later and gradually recovered, and the disease is not relapsed. So far, it is healthy.

Case two: zhangqi, male, hongzhou Xiangyun county, "pulmonary metastasis relapsed after 2 years after rectal cancer surgery, after multi-cycle chemotherapy" CT shows: the anterior segment of the right lung superior lobe has increased metabolism soft tissue nodule shadow, considered as metastasis, left right pneumonia change, little hydrops in the thoracic cavity on both sides, tonsillitis on other both sides, chronic cholecystitis, prostatitis \8230; and (4) disease detection: "(right supralung lobe lump) adenocarcinoma". It is accepted in 2016, 8 months and 5 days. The artemisia decoction of the traditional Chinese medicine 'dispersing and pain-relieving pill' is flavored and treated for nearly 1 year, various indexes are rechecked to restore the normal state, and the patients are healed, so far, the health is realized, and one or two million steps are kept healthy every day.

Case three: xie, woman, 43 years old, weixi county, pre-cervical cancer. The disease examination of the Kunming city maternal and child health care hospital (# 201700220) in 3 and 2 months in 2017 finds that ' chronic cervicitis, part CIN1 ' is detected ', and the disease examination is reviewed in 29 days in 3 and 29 months after the operation, and an electronic colposcope (# 20170329-104252C) shows that: a neoplasm of about 0.3cm in diameter (property to be diagnosed) is visible in the upper cervical lip. The pill is collected in 2017, 4 and 12 months, and the pill is taken together with the artemisia decoction. The follow-up examination is returned to normal after 3 months: the ultra-thin cell detection (# 201705336) "has no squamous intraepithelial lesion or malignant lesion", the human papillomavirus HRV genotyping detection (-) "is low-risk negative and high-risk negative", and the patient is cured in the first 1 treatment course and has no relapse.

Case four: zhang, female, age 40, shangri-La City, pre-mammary lesion. The breast on both sides is distending pain before menstruation, the lump is found to be more than 5 years, and the breast lump is usually taken and local traditional Chinese medicines do not take effect. The report of tumor hospital color Doppler ultrasound (B1910310610) in Yunnan province in 2 months in 2019 shows that: left-sided mastocystic space occupying lesion (9 x3 mm) Bl-RADS: class 2, right breast nodules (7 x4 mm) Bl-RADS: class 4A, bilateral breast 2, 3 nodules (maximum about 10x4 mm) Bl-RADS: class 3. The disease is collected in 12 months and 5 days in 2019. The invention provides a Chinese medicine 'Xiaopi antalgic pill', which is taken together with the artemisia decoction. CT review after 4 treatment sessions, shrinkage of the largest nodules (from 10x4mm to 8x4 mm), right breast by BI-RADS:4 types are converted into 3 types, so that the risk of malignant transformation is greatly reduced. No recurrence has occurred so far.

Case five: ji Yi, woman, age 40, nu Jiang Zhou health care institute worker, "rectal cancer with liver and lung metastasis after chemotherapy". In 2015, rectal cancer operation is performed, mucus and bloody stool are generated in half a year before pain due to lower abdomen falling and swelling, cough and asthma and upper abdomen swelling pain are accompanied, and the disease examination in Yunnan province tumor hospital (# H201703041) reports: "rectal tubular adenocarcinoma liver-lung metastasis", MRl (# 1586132) in this hospital on 2/6/2018 showed "after rectal cancer with liver-lung metastasis chemotherapy, the liver is frequently occupied, and the maximum is about 1.3cmx1.2cm". After the 4 times of chemotherapy, the constitution is too weak to bear the toxic reaction of the chemotherapy, and the chemotherapy is refused to continue to be performed, so that the treatment is accepted in 2018, 2 and 10 months. Generally, the situation is poor, the chemotherapy is feared, the number of grains is obviously reduced, and the traditional Chinese medicine is required to be taken. The Chinese medicine 'Xiaopi antalgic pill' is taken together with the artemisia decoction. After 1 year, the body can recover, 33 blood is normal, and the patient returns to work. The spring festival is followed up in 2020, and the recovery is as usual.

Six cases: tian Yi, man, 51 years old, he Qing county, "primary liver cancer, hepatitis B (active stage), liver cirrhosis". Tumor hospital CT (# 16992998) in Yunnan province shows: the largest liver mass is about 2.2x2.8cm, and the diagnosis is confirmed by combining disease detection and biochemical detection. The harvest was in 2018, 8 and 23 days. The first intervention chemotherapy in hospitals combines the application of the traditional Chinese medicine 'Xiaopi antalgic pill' and is taken for more than 1 year with the addition of the artemisia decoction. After the first few times of intervention, the liver area is hard to suffer from severe pain after chemotherapy, and the intervention is suspended after the oral analgesic is taken to relieve pain, and the treatment is continued. After 1 year, review of CT (# 1296998) shows: the largest mass in the liver is reduced to 0.6cm, and other masses disappear completely; the liver function is improved earlier; blood tests showed that: the tumor necrosis factor, interferon, natural killer cell, inductivity killer cell and other cell factors which are beneficial to resisting cancer are obviously increased, other items are basically recovered to be normal without discomfort, the weight is raised by more than ten jin, the patient is basically recovered, and the 'chronic disease' consolidation treatment is carried out. The follow-up visit in autumn in 2020 is healthy.

Case seven: hu-shi, female, 65 years old, changsha, and "lung cancer with multiple bone metastases". Can not get out of bed, is diagnosed by three Hunan ya hospitals of the university of Zhongnan for more than one year, and carries out targeted treatment and radiotherapy in the hospital again. CT (# ID 2022293) of this hospital on 17 th 12.2018: after primary bronchogenic carcinoma radiotherapy, the metastasis of the left 2 nd rib is approximately in the same front, and the metastasis of the right rib, the ilium, the sacrum and the left femur are approximately in the same front. The disease condition of the oral administration of the oxcetinic acid and the stage radiotherapy is not improved for more than one year, and the treatment is received in 2019, 1 month and 2 days. The traditional Chinese medicine 'Xiaopi antalgic pill' is taken with the artemisia decoction in a flavoring manner for 5 courses, can be put down to bed to support two or three herbs, and can improve appetite by one herb and more herbs, recover physical ability day by day and remarkably improve the state of an illness by 3 courses of treatment.

Eight cases: yang, female, 67 years old, following an retirement teacher, "recurrence after differentiated adenocarcinoma in colon". After 12 and 15 days in 2018 and after the first people hospital in Zuyi city, postoperative pathology confirms that the right mid-colon cancer differentiation is performed, the tumor size is 5cmx5cmx2.5cm, the cancer tissue infiltrates the whole layer of the intestinal wall, the vascular and nerve infiltration is seen, multiple lymph node tumor metastasis is seen in the fat tissue around the intestine, the diagnosis is performed after the secondary chemotherapy in 4 and 6 days in 2019, and the traditional Chinese medicine 'Xiaopi antalgic pill' is taken with the taste of artemisia decoction. After half a year, the indexes of CT, electronic colonoscope, three major routine, liver and kidney functions and the like are all recovered to be normal, and the recovery of diseases is as normal as before.

Nine cases: yin Zhi, female, 62 years old, kunming, double lung multiple nodes. The cough is easy to catch a cold at ordinary times, the cough is delayed and not cured, the recurrent cough sputum in 6 months and 5 days in 2019 has a small amount of blood, and the CT (# 520837) of the second hospital in Yunnan province shows that: 3 solid nodules in the lung, the larger of which is positioned at the tip section of the upper lobe of the right lung, the size of which is about 2.8x2 and 2mm, and no special treatment is performed; and then, the patient is subjected to small amount of blood cough once, and 7 solid nodules in the lung are rechecked by CT (# 531043), wherein the size of a left lung inferior lobe nodule is about 1.1x3.7mm, and the size of a left lung superior lobe nodule is about 5.7x3.5mm. The pill is taken in 2019, 10 months and 19 days, the traditional Chinese medicine 'Xiaopi antalgic pill' is taken for 8 courses of treatment by adding the artemisia decoction, and the CT shows that: no real change image and nodular high-density image are found in the two lungs, and the image is absorbed by the ground glass. The symptoms are completely absent, and the recovery is as usual.

Ten cases: von, male, 82 years old, kunming retirement medical specialist, "prostatic adenocarcinoma". Before 1 year, the disease is caused by 'dysuria and recurrence after prostatomegaly'. And 5, 21, 24 days in 2020, the Hospital of Kunmiki and the Hospital check of the prostate specific antigen: F-PSA13.85nk/ml, PAS188.94nk/ml, F-PSA/T-PSA 7.33%, diagnosis of disease (# 20PB 00397): adenocarcinoma of the prostate. No operation is performed for the moment, and the treatment is accepted in 2021 year, 1 month and 13 days. The Chinese medicine 'Xiaopi antalgic pill' is taken by taking the artemisia decoction with a certain flavor, and after 2 treatment courses, the urination is smooth without other discomfort, and the prostate specific antigen is basically reduced to normal; after 9 treatment courses, the patients recover as usual, and are healthy and move for one or two thousand steps every day. Review CT and nmr reports: "the focus is repaired and is not abnormal, the former two pulmonary nodules control and the pleural effusion are completely absorbed"; and (4) displaying an inspection report: various indexes related to malignant tumor are recovered to normal.

Claims

1. The traditional Chinese medicine for treating advanced cancer is characterized by being prepared from the following medicinal materials in parts by weight: 15-30 parts of potassium nitrate, 15-30 parts of radix curcumae, 15-30 parts of alum, 25-50 parts of fructus aurantii, 15-30 parts of prepared frankincense, 15-30 parts of prepared myrrh, 3-6 parts of liquorice, 120-140 parts of prepared nux vomica, 15-30 parts of rhizoma corydalis, 15-30 parts of Japanese thistle herb, 15-30 parts of astragalus membranaceus and 15-30 parts of prepared sea buckthorn fruit.

2. The traditional Chinese medicine for treating advanced cancer according to claim 1, which is prepared from the following medicinal materials in parts by weight: 20 parts of potassium nitrate, 20 parts of radix curcumae, 20 parts of alum, 30 parts of fructus aurantii, 20 parts of prepared frankincense, 20 parts of prepared myrrh, 5 parts of liquorice, 120 parts of prepared nux vomica, 20 parts of rhizoma corydalis, 15 parts of Japanese thistle herb, 20 parts of astragalus and 20 parts of prepared sea buckthorn fruit.

3. The traditional Chinese medicine treatment for treating advanced cancer according to claim 1, wherein the dosage form of the traditional Chinese medicine comprises powder, tablets, pills, granules, capsules, suppositories and injections.

4. The traditional Chinese medicine for treating advanced cancer according to claim 1, wherein the preparation method of the prepared seabuckthorn fruit comprises the following steps: adding sand into an iron pan, parching at 180-200 deg.C, adding clean fructus Hippophae, continuously turning, scalding until the surface of fructus Hippophae is brown or dark brown, taking out, sieving to remove sand, quickly rinsing fructus Hippophae with water, and air drying.

5. The method for preparing the traditional Chinese medicine for treating advanced cancer according to claim 1, wherein the traditional Chinese medicine preparation is a pill, and the preparation method comprises the following steps:

(1) Preparation of raw materials: removing impurities from the medicinal materials, weighing, mixing and crushing the medicinal materials according to the parts by weight, and sieving the medicinal materials by a 100-mesh sieve to obtain medicinal powder;

(2) Stripping: spraying water into the pill making pot until the inner wall of the pill making pot is in a wet state, spreading a small amount of the medicinal powder into the pill making pot to ensure that the medicinal powder just covers the bottom wall of the pill making pot, rotating the pill making pot, brushing the wall of the pot to adhere to the powder particles, spraying water and scattering the powder, repeatedly circulating for many times to gradually increase the powder particles until spherical particles with the diameter of 1-2mm are made, and sieving the particles with a sieve of 10 meshes to 24 meshes to obtain a pill mold;

(5) And (3) drying: drying the pills covered with the flour in time to ensure that the water content is less than or equal to 9 percent;

(7) Coating: and (4) coating, polishing and drying the pills obtained in the step (6).

6. The preparation method of the traditional Chinese medicine for treating advanced cancer according to claim 5, wherein the rotation speed of the pill making pan is controlled at 40-45r/min.

7. The method for preparing a Chinese medicinal composition for treating advanced cancer as claimed in claim 5, wherein the drying method in step (5) is microwave drying.

8. The preparation method of the Chinese herbal preparation for treating advanced cancer according to claim 5, wherein the coating material in the step (7) is licorice coating.