CN115282190A - A skin antibacterial liquid containing plant extract and its preparation method - Google Patents
A skin antibacterial liquid containing plant extract and its preparation method Download PDFInfo
- Publication number
- CN115282190A CN115282190A CN202210628263.1A CN202210628263A CN115282190A CN 115282190 A CN115282190 A CN 115282190A CN 202210628263 A CN202210628263 A CN 202210628263A CN 115282190 A CN115282190 A CN 115282190A
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- Prior art keywords
- extract
- parts
- skin
- plant extracts
- skin bacteriostatic
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- 229910017053 inorganic salt Inorganic materials 0.000 claims abstract description 19
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- 239000002994 raw material Substances 0.000 claims abstract description 11
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000000284 extract Substances 0.000 claims description 55
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- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 10
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Classifications
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Abstract
The invention relates to the field of IPC A61K36, in particular to a skin bacteriostatic liquid containing plant extracts and a preparation method thereof. The preparation raw materials comprise the following components in parts by weight: 1-30 parts of plant extract, 1-10 parts of inorganic salt, 1-8 parts of traditional Chinese medicine and 60-100 parts of purified water. The skin bacteriostatic solution containing the plant extract can simultaneously inhibit escherichia coli and staphylococcus aureus, has good and stable bacteriostatic effect, is mild and non-irritant, and is suitable for most people.
Description
Technical Field
The invention relates to the IPC A61K36 field, especially relates to the technical field of antibacterial liquid, and more specifically relates to a skin antibacterial liquid containing plant extracts and a preparation method thereof.
Background
At present, with the continuous development of society, the living rhythm of people is continuously accelerated, and the poor skin resistance of people is caused by irregular diet and night stay, so that various skin diseases are easily caused by bacterial infection.
Escherichia coli is a gram-negative bacterium, and can cause diseases such as pneumonia, peritonitis, meningitis and the like under certain conditions, particularly children, old people and other people with low resistance, severe infection can be easily caused after the Escherichia coli is infected, and people with serious disease can have life risks.
Staphylococcus aureus is the second pathogenic bacterium which is second to Escherichia coli for human bodies, and skin is easily subjected to local suppurative infection when being injured, so that infectious diarrhea, pneumonia, pericarditis and other diseases can be caused, and the staphylococcus aureus has strong drug resistance.
In the prior art, a patent application publication No. CN 101721505A discloses a pseudoShengma rhizome extract with bacteriostatic activity, which has a good inhibitory effect on staphylococcus aureus but a poor inhibitory effect on escherichia coli.
The application publication No. CN108524513A discloses an application of strychnine sulfate, a bacteriostatic composition, an application of strychnine sulfate and a bacteriostatic preparation, wherein the addition of strychnine sulfate and strychnine sulfate enables the bacteriostatic preparation to inhibit Escherichia coli and Staphylococcus aureus at the same time, but the bacteriostatic effect is limited.
Therefore, it is necessary to develop a skin bacteriostatic solution which can inhibit escherichia coli and staphylococcus aureus simultaneously, has good and stable bacteriostatic effect, is mild and non-irritating, and is suitable for most people.
Disclosure of Invention
In order to solve the above problems, in a first aspect of the present invention, a skin bacteriostatic solution containing plant extracts is provided, which is prepared from the following raw materials, by weight: 1-30 parts of plant extract, 1-10 parts of inorganic salt, 1-8 parts of traditional Chinese medicine and 60-100 parts of purified water.
Preferably, the skin bacteriostatic solution containing the plant extract comprises the following preparation raw materials in parts by weight: 5-20 parts of plant extract, 3-8 parts of inorganic salt, 2-6 parts of traditional Chinese medicine and 70-90 parts of purified water.
Preferably, the plant extract is selected from one or more of rhubarb (Rheum officinale baill.) extract, angelica dahurica (fisch. Ex hoffm.) Benth.et hook.f.ex franch.et Sav.) extract, honeysuckle (Lonicera japonica thunb.) extract, forsythia suspensa (Forsythia subsp. Extract), levorotatory borneol (Blumea balsamira (L) DC.), smoked plum (Prunus me (Sieb.) Sieb. Et Zuce.) extract, peucedanum praeruptorum Dunn (Peucedanum. Dunn) extract, zanthoxylum nitidum (Roxb.) DC) extract, notoginseng (Panax nozolgenseng (Burkii) F.H.n. C.H.) extract, licorice (licorice root) extract; further preferred are rhubarb (Rheum officinale baill.) extract, licorice (Glycyrrhiza uralensis fisch.) extract, and levoborneol (Blumea balsamira (L) dc.).
Preferably, the mass ratio of the rhubarb (Rheum officinale baill.) extract to the licorice (Glycyrrhiza uralensis fisch.) extract to the L-borneol (Blumea balsamira era (L) DC.) is (1-10): (1-10): 1; further preferred is 5.
The applicant finds that the rhubarb (Rheum officinale baill.) extract, the liquorice (Glycyrrhiza uralensis fisch.) extract and the levoborneol (Blumea balsamiera (L) dc.) are selected as the plant extracts, so that the skin bacteriostatic solution has simple components and no heavy metal components, and the inhibition rate of the skin bacteriostatic solution on escherichia coli and staphylococcus aureus can be effectively improved. The rhubarb (Rheum officinale Baill.) extract contains chemical substances such as anthraquinone compounds, anthrone compounds, tanning compounds and the like, wherein the anthraquinone compounds contain free anthraquinones such as emodin, chrysophanol and the like, can inhibit bacteria such as helicobacter pylori, escherichia coli, staphylococcus aureus and the like, and also has a certain anti-inflammatory effect. The applicant finds that the cold property of rhubarb can be adjusted while the bacteriostatic effect is maintained by adding the liquorice (Glycyrrhiza uralensis Fisch.) extract and the L-borneol (Blumea balsamiera (L) DC.). The liquorice is sweet in nature and taste, can not only moderate the property of rhubarb, but also can synergistically act with rhubarb (Rheum officinale Baill.) extract to promote the inhibition effect on escherichia coli and staphylococcus aureus, the levorotatory borneol (Blumea balsamiera L) has faint scent and pungent and cool taste, has the effects of inducing resuscitation, refreshing mind, clearing heat and relieving pain, can relieve dizziness and nausea caused by excessive use of rhubarb, and also has the effects of diminishing inflammation and resisting bacteria when being mutually compatible with the liquorice (Glycyrrhiza uralensis Fisch.) extract and the rhubarb (Rheum officinale Baill.) extract. The applicant has unexpectedly found that when the mass ratio of rhubarb (Rheum officinale baill.) extract, licorice (Glycyrrhiza uralensis fisch.) extract and L-borneol (Blumea balsamira era (L) dc.) is (1-10): (1-10): 1, the prepared skin bacteriostatic liquid has cool smell and comfortable use, has low heavy metal content and no damage to human bodies, has low colony count, and has strong inhibiting effect on escherichia coli and staphylococcus aureus.
In some preferred embodiments, the rhubarb (Rheum officinale baill.) extract and the licorice (Glycyrrhiza uralensis fisch.) extract are prepared by the steps of:
respectively pulverizing radix et rhizoma Rhei and Glycyrrhrizae radix to obtain powder, sieving with 60-100 mesh sieve, drying at 60-100 deg.C, weighing part of the powder, adding 5-20ml ethanol water solution, performing ultrasonic treatment at 30-40 deg.C, centrifuging the solution in a centrifuge tube after the ultrasonic treatment, filtering, collecting supernatant, mixing ethanol, and concentrating to obtain solid radix et rhizoma Rhei (Rheum officinale Baill.) extract and Glycyrrhrizae radix (Glycyrrhiza uralensis Fisch.) extract.
Preferably, the concentration of ethanol in the ethanol aqueous solution is 70-95wt%; more preferably, it is 85wt%.
Preferably, the ultrasonic treatment comprises the following specific steps: the ultrasonic treatment time is 20-40min, and the ultrasonic treatment is carried out for 1-5 times; further preferably, each time of ultrasonication is 30min, and ultrasonication is performed 3 times.
The plant components are safe and have wide sources, but the extraction rate is low, the waste of the effective components in the extraction process is serious, and the traditional extraction method consumes long time and is not suitable for mass production. The applicant unexpectedly finds that the plant extract obtained by adding the plant powder into ethanol water solution with the ethanol concentration of 70-95wt% and carrying out ultrasonic treatment for 20-40min each time has high extraction rate after ultrasonic treatment for 1-5 times. The ultrasonic wave has the effects of mechanical crushing, stirring and the like, so that the plants can be prevented from being instantaneously collapsed and broken in the solvent, the solvent can permeate into plant cells and fully contact with the plant cells, impurities are dissolved, the extraction rate is improved, the amount of the solvent entering the cells is large when the ultrasonic time is long, the impurity dissolving efficiency is high, but the structure of emodin is damaged under the long ultrasonic treatment, and the content of the extracted rhubarb (Rheum officinale Baill) extract is low. When the concentration of ethanol in the solvent is increased, the diffusion and solubility of impurities in the solvent are improved, so that the extraction rate is improved, but the concentration of ethanol in the solvent is too high, so that the phenomena of dehydration, protein denaturation in cells and the like appear in the cells, the diffusion of the impurities is inhibited, and the extraction rate is reduced. When the concentration of ethanol in the ethanol water solution is 70-95wt%, the ultrasonic time is 20-40min, and the plant extract obtained by ultrasonic treatment is high in extraction rate, short in time consumption and simple to operate, and can be widely applied. However, the natural extract is applied to the skin bacteriostatic solution, and the natural extract is safe in ingredients but poor in stability.
The rhubarb and the liquorice are purchased from markets, and specific manufacturers and models are not limited.
The CAS number of the levorotatory borneol (Blumea balasamiera (L) DC.) is 464-45-9.
Preferably, the traditional Chinese medicine is selected from one or more of fructus liquidambaris, talcum powder, codonopsis pilosula, nauclea officinalis, buddleia, dysosma versipellis, divaricate saposhnikovia root, irkutsk anemone rhizome, emilia sonchifolia and paniculate swallowwort root; further preferably, the traditional Chinese medicine is selected from talcum powder.
Preferably, the weight ratio of the traditional Chinese medicine to the plant extract is 1: (1-5); further preferably, 4.
In order to improve the stability of the skin antibacterial liquid, in some preferable schemes, the talcum powder is selected as a traditional Chinese medicine, when skin is irritated or injured by the outside, a large amount of irritants and toxicants can be absorbed, the skin is protected while the bacterial growth is inhibited, the talcum powder has small particles and large specific surface area, can be well dispersed in a system, and when the weight ratio of the talcum powder to the plant extract is 1: and (1-5), the talcum powder can coordinate with the plant extract, so that the stability and the lubricity of the product can be improved while the plant extract is promoted to exert the antibacterial effect.
Preferably, the inorganic salt is selected from one or more of sodium salt, potassium salt, silicate, calcium salt, iron salt and iodide; further preferably, the inorganic salt is selected from sodium salts; the sodium salt is selected from one or more of sodium chloride, edible alkali and sodium sulfate; more preferably, it is dietary alkali.
Preferably, the ratio of the inorganic salt to the traditional Chinese medicine is 1: (0.5-2); further preferably, it is 5.
In order to reduce the irritation to the skin, in some preferred embodiments, edible alkali is selected as the inorganic salt. When the antibacterial liquid containing plant extracts is used, the skin is irritated, and the skin becomes red and even becomes allergic. The applicant finds that the addition of a proper amount of edible alkali serving as inorganic salt in the raw materials not only has a certain sterilization effect, but also can reduce the irritation of the skin bacteriostatic liquid to the skin. Microorganisms such as bacteria, fungi and viruses are mostly suitable for growing under acidic conditions, and die when the microorganisms are under weakly alkaline conditions, but excessive alkali can affect the acid-base balance on the surface of the skin, so that the microorganisms can cause irritation to the skin. The applicant unexpectedly found that when the weight ratio of the selected inorganic salt to the traditional Chinese medicine is 1: (0.5-2), the obtained skin antibacterial liquid has extremely low bacterial colony count, low skin irritation, and stable inhibition effect on Escherichia coli and Staphylococcus aureus.
The second aspect of the present invention provides a preparation method of the skin bacteriostatic liquid containing the plant extracts, which comprises the following steps:
(1) Cleaning and drying the plant extract and the traditional Chinese medicine to obtain a first mixture;
(2) Mixing the mixture I with inorganic salt, crushing, and sieving with a 5-20 mesh sieve;
(3) Soaking the raw materials in the step (2) in an ethanol water solution with the ethanol concentration of 40-60wt% for 25-40h, sieving with a 5-20-mesh sieve, and drying to obtain a second mixture;
(4) Adding purified water into the mixture II, and stirring for 20-40min to obtain a mixture III;
(5) Sterilizing the mixture III under high pressure at 50-150kPa and 100-200 deg.C for 30-50min to obtain mixed solution, and cooling.
Has the beneficial effects that:
1. selecting the following components in percentage by mass (1-10): (1-10): 1, the rhubarb (Rheum officinale Baill.) extract, the licorice (Glycyrrhiza uralensis Fisch.) extract and the L-borneol (Blumea balsamira era (L) DC.) are taken as plant extracts, so that the skin bacteriostatic solution has simple components and no heavy metal components, and the inhibition rate of the skin bacteriostatic solution on escherichia coli and staphylococcus aureus can be effectively improved.
2. The plant extract is prepared by ultrasonic assisted extraction, ethanol water solution with ethanol concentration of 70-95wt% is selected, ultrasonic time is 20-40min, and ultrasonic is carried out for 1-5 times, so that the obtained plant extract has high extraction rate, short time consumption and simple operation, and is suitable for industrial production.
3. Selecting a weight ratio of 1: (1-5) the traditional Chinese medicines and the plant extracts can coordinate with each other, so that the plant extracts are promoted to exert the bacteriostatic effect, and meanwhile, the stability and the lubricity of the product can be improved.
4. Selecting a raw material with the weight ratio of 1: (0.5-2) inorganic salt and traditional Chinese medicine, so that the total number of bacterial colonies and fungi in the prepared skin bacteriostatic liquid is extremely low, the skin irritation is small, and the inhibition effect on escherichia coli and staphylococcus aureus is stable.
5. The skin antibacterial liquid prepared by the invention is suitable for various skin types, such as sensitive skin types, acne-removing skin types, dry skin types and the like.
Detailed Description
Examples
Example 1
Embodiment 1 provides a skin bacteriostatic agent containing plant extracts, which is prepared from the following raw materials in parts by weight: 11 parts of plant extract, 5 parts of inorganic salt, 4 parts of traditional Chinese medicine and 80 parts of purified water;
the plant extract is selected from radix et rhizoma Rhei (Rheum officinale Baill.) extract, glycyrrhrizae radix (Glycyrrhiza uralensis Fisch.) extract and L-borneol (Blumea balsamira (L) DC.) (CAS No. 464-45-9); the weight ratio of rhubarb (Rheum officinale baill.) extract, licorice (Glycyrrhiza uralensis fisch.) extract and L-borneol (Blumea balsamiera era (L) dc.) was 5.
The preparation steps of the rhubarb (Rheum officinale Baill.) extract and the licorice (Glycyrrhiza uralensis Fisch.) extract are as follows:
respectively pulverizing radix et rhizoma Rhei and Glycyrrhrizae radix to obtain powder, sieving the powder with 80 mesh sieve, drying at 80 deg.C, weighing 1g of powder, adding 15ml ethanol water solution with 85wt% ethanol concentration, performing ultrasonic treatment at 35 deg.C for 30min, performing ultrasonic treatment for 3 times, pouring the solution into a centrifuge tube, centrifuging at 6000r/min for 15min, filtering, collecting supernatant, mixing the ethanol, and concentrating to obtain radix et rhizoma Rhei (Rheum officinale Baill.) extract and Glycyrrhrizae radix (Glycyrrhiza uralensis Fisch.) extract.
The CAS number of the levorotatory borneol (Blumea balasamiera (L) DC.) is 464-45-9.
The traditional Chinese medicine is selected from talcum powder; the talc powder has a CAS number of 14807-96-6.
The inorganic salt is selected from sodium salt; the sodium salt is selected from dietary alkali.
The second aspect of the present invention provides a preparation method of the skin bacteriostatic solution containing the plant extract, which comprises the following steps:
(1) Cleaning and drying the plant extract and the traditional Chinese medicine to obtain a first mixture;
(2) Mixing the first mixture with inorganic salt, crushing, and sieving by a 15-mesh sieve;
(3) Soaking the raw materials in the step (2) in an ethanol water solution with the ethanol concentration of 50wt% for 30 hours, sieving with a 15-mesh sieve, and drying to obtain a second mixture;
(4) Adding purified water into the mixture II, and stirring for 30min to obtain a mixture III;
(5) And (3) placing the mixture III into a pressure of 130kPa and a temperature of 150 ℃ for autoclaving treatment for 40min to prepare a mixed solution IV, and cooling to obtain the product.
Example 2
Example 2 provides a skin bacteriostatic agent containing plant extracts, which is implemented in the same manner as example 1, except that: the plant extract is radix et rhizoma Rhei (Rheum officinale Baill).
Example 3
Example 3 provides a skin bacteriostatic agent containing plant extracts, which is implemented in the same manner as example 1, except that: the plant extract is Glycyrrhrizae radix (Glycyrrhiza uralensis Fisch.) extract and L-borneol (Blumea balsamira era (L) DC.); the weight ratio of the licorice (Glycyrrhiza uralensis fisch.) extract to levoborneol (Blumea balsamiera (L) dc.) was 5.
The preparation method of the licorice (Glycyrrhiza uralensis Fisch.) extract comprises the following steps:
pulverizing Glycyrrhrizae radix to obtain powder, sieving with 80 mesh sieve, drying at 80 deg.C, weighing 1g of powder, adding 15ml of 85wt% ethanol water solution, performing ultrasonic treatment at 15 deg.C for 30min each time, performing ultrasonic treatment for 3 times, centrifuging the solution at 6000r/min in a centrifuge tube for 15min after ultrasonic treatment, filtering, collecting supernatant, mixing with ethanol, and concentrating to obtain Glycyrrhrizae radix (Glycyrrhiza uralensis Fisch.) extract.
The CAS number of the levorotatory borneol (Blumea balasamiera (L) DC.) is 464-45-9.
Example 4
Example 4 provides a skin bacteriostatic agent containing plant extracts, which is implemented in the same manner as example 1, except that: the ultrasonic treatment time is 50min.
Example 5
Example 5 provides a skin bacteriostatic agent containing plant extracts, which is similar to example 1 in specific implementation, except that: no talc was added.
Example 6
Example 6 provides a skin bacteriostatic agent containing plant extracts, which is implemented in the same manner as example 1, except that: the inorganic salt is sodium chloride.
Performance test method
1. Physical and chemical properties
(1) And (3) pH test:
the skin bacteriostatic solution prepared in example 1 was measured for pH by a pH meter according to the method for measuring pH in the "disinfection specification" (2002), and the measured data are shown in table 1.
(2) And (3) testing the content of heavy metal:
the skin bacteriostatic solution prepared in example 1 was tested for the content of heavy metals of lead, arsenic and mercury in the skin bacteriostatic solution according to the method specified in technical specifications for cosmetic safety (2015 edition), and the measured data are shown in table 1.
2. Microbial count test
The skin bacteriostatic solution prepared in example 1 was tested for the total number of bacterial colonies, the total number of fungal colonies, coliform group bacteria, staphylococcus aureus, pseudomonas aeruginosa and hemolytic streptococcus according to the method specified in GB 15979-2002 hygienic Standard for Disposable hygiene products, and the results are shown in table 2.
3. Bacteriostasis and stability test
(1) Test of bacteriostatic Property
The skin bacteriostatic solution prepared in examples 1-6 has bacteriostatic rates to escherichia coli and staphylococcus aureus after 2min, 5min, 10min and 20min according to the method specified in GB 15979-2002 hygienic Standard for Disposable sanitary products, and the results are shown in Table 3.
(2) Stability test
The skin bacteriostats prepared in examples 1-6 were tested for stability according to the method specified in GB 15979-2002 hygienic Standard for Disposable sanitary products. The solutions of the skin bacteriostatic agents were observed after 3 months at 37 ℃ and the results are shown in Table 4.
4. Toxicological test evaluation index
For the skin bacteriostatic solution prepared in example 1, according to a corresponding method in "disinfection technical specification" (2002 edition), common guinea pigs are selected as experimental animals, the skin bacteriostatic solution is dripped on the unhaired skin surface of the guinea pigs, and is covered with oiled paper, and is fixed with non-irritating adhesive tape, and skin tissue reactions at the application position 1h, 24h and 48h after the skin bacteriostatic solution is dripped are observed, and the results are recorded in table 5.
TABLE 1 physicochemical Properties
TABLE 2 microbial count test
TABLE 3 bacteriostatic Property test
TABLE 4 stability test
| 37 ℃ and the solution state after 3 months of standing | |
| Example 1 | No demixing, no precipitation, clear solution and no color change |
| Example 2 | The occurrence of demixing, partial precipitation and turbidity of the solution |
| Example 3 | No demixing, partial precipitation, clear solution and no color change |
| Example 4 | No demixing, no precipitation, clear solution and no color change |
| Example 5 | The occurrence of demixing, partial precipitation and turbidity of the solution |
| Example 6 | The occurrence of demixing, partial precipitation and turbidity of the solution |
TABLE 5 toxicological test
Claims (10)
1. A skin bacteriostatic solution containing plant extracts is characterized by comprising the following preparation raw materials in parts by weight: 1-30 parts of plant extract, 1-10 parts of inorganic salt, 1-8 parts of traditional Chinese medicine and 60-100 parts of purified water.
2. The skin bacteriostatic liquid containing plant extracts as claimed in claim 1, which is prepared from the following raw materials in parts by weight: 5-20 parts of plant extract, 3-8 parts of inorganic salt, 2-6 parts of traditional Chinese medicine and 70-90 parts of purified water.
3. The skin bacteriostatic solution containing the plant extract according to claim 1 or 2, wherein the plant extract is selected from one or more of rhubarb extract, angelica dahurica extract, honeysuckle extract, forsythia suspensa extract, levoborneol, smoked plum extract, peucedanum root extract, zanthoxylum nitidum extract, pseudo-ginseng extract and liquorice extract.
4. The skin bacteriostatic solution containing plant extracts as claimed in claim 1 or 2, wherein the inorganic salt is selected from one or more of sodium salt, potassium salt, silicate, calcium salt, iron salt and iodide.
5. The skin bacteriostatic liquid containing plant extracts as claimed in claim 1 or 2, wherein the Chinese herbal medicines are selected from one or more of fructus liquidambaris, talcum powder, radix codonopsis pilosulae, radix naucleae officinalis, buddleia, dysosma versipellis, radix sileris, irkutsk anemone rhizome, emilia sonchifolia and paniculate swallowwort root.
6. The skin bacteriostatic solution containing plant extracts according to any one of claims 1-3, wherein the plant extracts are selected from rhubarb extract, licorice extract and L-borneol.
7. The skin bacteriostatic solution containing plant extracts as claimed in claim 6, wherein the preparation steps of the rhubarb extract and the licorice extract are as follows: pulverizing radix et rhizoma Rhei and Glycyrrhrizae radix to obtain powder, sieving with 60-100 mesh sieve, drying at 60-100 deg.C, weighing part of the powder, adding 5-20ml ethanol water solution, performing ultrasonic treatment at 30-40 deg.C, centrifuging the solution in a centrifuge tube after the ultrasonic treatment is finished, filtering, collecting supernatant, mixing ethanol, and concentrating to obtain solid plant extract.
8. The skin bacteriostatic solution containing plant extracts according to claim 7, wherein the concentration of ethanol in the ethanol aqueous solution is 70-95wt%.
9. The skin bacteriostatic liquid containing plant extracts according to any one of claims 1 to 8, wherein the weight ratio of the traditional Chinese medicine to the plant extracts is 1: (1-5).
10. A method for preparing a plant extract-containing skin bacteriostatic solution according to any one of claims 1 to 9, which comprises the following steps:
(1) Cleaning and drying the plant extract and the traditional Chinese medicine to obtain a first mixture;
(2) Mixing the mixture I with inorganic salt, crushing, and sieving with a 5-20 mesh sieve;
(3) Soaking the raw materials in the step (2) in an ethanol water solution with the ethanol concentration of 40-60wt% for 25-40h, sieving with a 5-20-mesh sieve, and drying to obtain a second mixture;
(4) Adding purified water into the mixture II, and stirring for 20-40min to obtain a mixture III;
(5) Sterilizing the mixture III under high pressure at 50-150kPa and 100-200 deg.C for 30-50min to obtain mixed solution, and cooling.
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| CN202210628263.1A CN115282190A (en) | 2022-06-06 | 2022-06-06 | A skin antibacterial liquid containing plant extract and its preparation method |
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