CN115282172A

CN115282172A - Method and device for processing anoectochilus roxburghii freeze-dried superfine powder and method for preparing oral liquid, capsule and electuary of anoectochilus roxburghii freeze-dried superfine powder

Info

Publication number: CN115282172A
Application number: CN202210920284.0A
Authority: CN
Inventors: 金鑫
Original assignee: Fujian Daoxiansheng Cultural Tourism Group Co ltd
Current assignee: Fujian Daoxiansheng Cultural Tourism Group Co ltd
Priority date: 2022-08-02
Filing date: 2022-08-02
Publication date: 2022-11-04

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a processing method and a processing device of anoectochilus roxburghii freeze-dried superfine powder, and a preparation method of oral liquid, capsules and granules of the anoectochilus roxburghii freeze-dried superfine powder. Anoectochilus formosanus compound traditional Chinese medicine raw materials comprise the following components in parts by weight: 45-55 parts of anoectochilus roxburghii, 5-10 parts of rhizoma polygonati, 5-15 parts of raspberry, 3-10 parts of lotus leaf, 3-10 parts of mulberry leaf, 5-10 parts of dendrobium officinale, 7-13 parts of astragalus mongholicus and 3-7 parts of radix puerariae. The anoectochilus roxburghii oral liquid, the capsule and the electuary provided by the invention not only can reduce blood sugar, but also can repair the function of human pancreatic islets, so that the content of human insulin is increased, and diabetes is fundamentally relieved and treated. Researches prove that the anoectochilus roxburghii oral liquid, the capsule and the electuary have the effects of protecting liver, reducing blood pressure, resisting tumor, relieving pain and diminishing inflammation.

Description

Method and device for processing anoectochilus roxburghii freeze-dried superfine powder and method for preparing oral liquid, capsule and electuary of anoectochilus roxburghii freeze-dried superfine powder

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a processing method and a processing device of anoectochilus roxburghii freeze-dried superfine powder, and a preparation method of oral liquid, capsules and granules of the anoectochilus roxburghii freeze-dried superfine powder.

Background

Anoectochilus roxburghii, known as guan ginseng, is a typical plant of the genus Orchidaceae, kaikang. The anoectochilus formosanus is neutral in nature and sweet in taste, has the functions of clearing heat and cooling blood, removing dampness and detoxifying, is used as a medicine by using the whole anoectochilus formosanus, is neutral in nature and sweet in taste, has the functions of clearing heat and cooling blood, dispelling wind and promoting diuresis, is mainly used for treating inflammation such as waist and knee arthralgia, nephritis, bronchitis and the like, diabetes, hematemesis, hematuria, infantile convulsion and the like, and is often used as a medicated diet for preventing and treating diseases and conditioning human body functions in China.

Diabetes is a metabolic disease characterized by hyperglycemia, which is caused by defects in insulin secretion or impaired biological action, or both. Hyperglycemia, which is present in long-term diabetes, leads to chronic damage to, dysfunction of, various tissues, particularly, the eyes, kidneys, heart, blood vessels, nerves.

With the rise of traditional Chinese medicine and traditional Chinese medicine science in recent years, substances contained in anoectochilus formosanus are paid more attention to, and a unique door is opened for analyzing the clinical effect of traditional Chinese medicine by a western medicine method. In ancient formulas, the effect of heat clearing and detoxifying of anoectochilus formosanus is improved, the toxin removing function of the anoectochilus formosanus as a traditional food habit of homology of medicine and food is quite effective, and researches show that the anoectochilus formosanus also has a good treatment effect on diabetes, so that the invention aims to disclose a preparation method of oral liquid, capsules and granules taking the anoectochilus formosanus as a main component.

The ultrafine grinder utilizes the forms of air separation, heavy pressure grinding and shearing to realize ultrafine grinding of dry materials, generally comprises mechanisms such as a grinding chamber, a grinding wheel and a grinding rail, and materials enter the grinding chamber through a feed port and are repeatedly ground and sheared by grinding mechanisms such as the grinding wheel to realize the grinding effect.

Anoectochilus roxburghii usually needs to be processed into freeze-dried ultrafine powder in the process of preparing medicines so as to facilitate the preparation of subsequent medicines, and patent application document with application number CN201810695107.0 discloses a small-sized ultrafine pulverizer with a self-cleaning mechanism, wherein traditional Chinese medicine powder in a pulverizing cavity is cleaned through a cleaning brush, so that although a good cleaning effect is achieved, part of powder remains on the brush, bacteria can be bred if the powder is not used for a period of time, the quality of the traditional Chinese medicine powder can be influenced if the powder is used again, and the freeze-drying process of the traditional Chinese medicine powder is not involved;

and current superfine pulverizer is at kibbling in-process, because the high-speed operation of inner structure, can produce high temperature in the crushing chamber, when smashing some article, can make by the soft of article that are smashed because the temperature risees, is unfavorable for smashing.

Disclosure of Invention

In order to solve the technical problems, the invention provides a processing method and a processing device of anoectochilus roxburghii freeze-dried superfine powder and a preparation method of oral liquid, capsules and granules of the anoectochilus roxburghii freeze-dried superfine powder.

The invention is realized by the following modes:

the active ingredients of the invention comprise the following components in parts by weight: 45-55 parts of anoectochilus roxburghii, 5-10 parts of rhizoma polygonati, 5-15 parts of raspberry, 3-10 parts of lotus leaf, 3-10 parts of mulberry leaf, 5-10 parts of dendrobium officinale, 7-13 parts of astragalus membranaceus and 3-7 parts of radix puerariae.

Further, the composition comprises the following components in parts by weight: 50 parts of anoectochilus roxburghii, 7 parts of rhizoma polygonati, 10 parts of raspberry, 5 parts of lotus leaf, 5 parts of mulberry leaf, 8 parts of dendrobium officinale, 10 parts of astragalus membranaceus and 5 parts of kudzu root.

The main raw materials of the invention are the anoectochilus roxburghii as the main functional component, and are matched with other traditional Chinese medicine components to assist the anoectochilus roxburghii in improving and repairing the liver and kidney functions and improving the liver and kidney functions, thereby fundamentally relieving and treating the diabetes.

Wherein, the anoectochilus roxburghii whole plant contains: 3-glucopyranosyl-4-hydroxybutyric acid glycoside and its derivatives: 3-glucopyranosyl-4-isopropoxybutyric acid (3-glucopyranosyloxy-4-isopropoxy butyric acid), methyl 3-glucopyranosyl-4-hydroxybutyrate (3-glucopyranosyloxy-4-hydroxybutyric acid ester), 3-glucopyranosyl-4-butanolide (3-glucopyranosyl-4-butanolide) ]. It also contains fat and vitamin C. And mineral elements of calcium, phosphorus, potassium, sodium, magnesium, iron, manganese, zinc and copper. The anoectochilus formosanus extract contains a large amount of flavone, anoectochilus formosanus polysaccharide, taurine, anoectochilus formosanus glycoside and other components, has the effects of nutrition, aging resistance and organism immunity regulation, particularly has the effect of removing free radicals, has very obvious treatment effect on a plurality of diseases such as hand-foot-mouth disease and the like, and researches show that the anoectochilus formosanus extract also has a certain effect of resisting HBV activity in vitro, and has obvious influence on blood pressure and plasma angiotensin II of a renal vascular hypertension rat.

The anoectochilus formosanus contains a large amount of components such as flavone, anoectochilus formosanus polysaccharide, taurine and anoectochilus formosanus glycoside, wherein the anoectochilus formosanus glycoside is a known main active component of the anoectochilus formosanus plant, has pharmacological effects of protecting liver, resisting hypertension, reducing blood sugar and the like, and is found through experiments that the anoectochilus formosanus glycoside can obviously reduce acute increase of serum alanine aminotransferase and aspartate aminotransferase caused by carbon tetrachloride and can improve liver tissues such as necrosis, fatty degeneration, balloon degeneration, lymphocyte and inflammatory exudation of Kupffer cells around central veins. .

Furthermore, the research finds that the anoectochilus formosanus has a remarkable prevention and treatment effect on the blood sugar rise of mice caused by alloxan, the further research finds that the blood sugar reducing mechanism of the anoectochilus formosanus polysaccharide is probably related to the fact that the anoectochilus formosanus polysaccharide prevents the absorption of glucose in the intestinal tracts of the mice, or influences the activity of metabolic enzymes to inhibit gluconeogenesis, or inhibits oxidative stress caused by hyperglycemia by improving the possibility of in vivo antioxidant enzymes, and the like, and the anoectochilus formosanus polysaccharide has a remarkable inhibition effect on the proliferation of prostate cancer cells.

In the analysis research of the anoectochilus roxburghii polysaccharide structure and the anti-diabetes, the finding shows that the anoectochilus roxburghii polysaccharide has stronger effect of removing free radicals in vitro experiments, has obvious effect of reducing blood sugar of mice with diabetes, can reduce and even repair tissue damage of the mice, and the anoectochilus roxburghii polysaccharide and flavone can finally achieve the effect of repairing pancreatic cells through a human body mechanism.

Rhizome of Polygonatum sibiricum contains steroid saponin, and 2 furostanol type saponins and 2 spirostanol type saponins are separated. The former is that: 26-O-beta-D-glucopyranosyl-22-O-methyl- (25) S-furost-5-ene-3 beta, 26-diol 3-O-beta-lycoris tetraoside (26-O-beta-D-glucopyranosyl-22-O-methyl-25 (S) -furost-5-ene-3 beta, 26-diol 3-O-beta-lycotetraoside), namely sibirioside A (sibirioside A) and 26-O-beta-glucopyranosyl-22-O-methyl-25 (S) -furost-5-ene-3 beta, 14 alpha, 26-triol 3-O-beta-lycoris tetraoside (26-O-beta-D-glucopyranosyl-22-O-25 (S) -furost-5-ene-3 beta, 14 alpha-xyloside-3 alpha, 26-xyloside-O-beta-lycoris tetraoside A (14 alpha-hydroxy alpha-14 alpha-xyloside A); the ones belonging to the latter are: ((23S, 25R) spirost-5-ene-3 beta, 14 alpha, 23-triol 3-O-beta-lycotetraoside) namely sibirian polygodide B and neobazagenin-A3-O-beta-lycoris tetraoside. The sealwort polysaccharide A, B and C are contained, the relative molecular mass of the sealwort polysaccharide A, B and C is more than 20 ten thousand, and the sealwort polysaccharide A, B and C are prepared by mixing glucose (glucose), mannose (mannose) and galacturonic acid (galacturonic acid) according to a molar ratio of 6:26:1, condensation to obtain; and contains polygonatum oligosaccharide A, B and C, the relative molecular mass is 1630, 862 and 472 respectively, and the molecular weight is determined by the molar ratio of fructose (fructose) to glucose (8: 1.4:1 and 2:1 is condensed.

The diabetes patients are generally accompanied with symptoms such as hyperlipidemia, hypertension, constipation and the like, and the compatibility of anoectochilus formosanus has obvious effect on diabetes symptoms.

Influence of rhizoma polygonati on blood sugar: the blood sugar content of the rabbit gavage rhizoma polygonati extract is gradually increased and then decreased. The rhizoma Polygonati extract has significant inhibitory effect on hyperglycemia caused by epinephrine. Raspberry (Rubus idaeus L.) is a woody plant of Rubus of Rosaceae, is a fruit, tastes sour and sweet, and has barb grown on the branch and stem of the plant. Raspberries have many aliases, such as: rubus Suavissimus, raspberry, wild raspberry, and black currant. The raspberry fruit contains abundant nutrient elements such as vitamin A, vitamin C, calcium, potassium, magnesium and the like and a large amount of fiber. Every 100 g of raspberry contains 87% of water, 0.9 g of protein and 4.7 g of fiber, and can provide 209.3 kilojoules of heat. Raspberry can effectively relieve cardiovascular diseases such as angina pectoris, but slight diarrhea can be caused sometimes. The raspberry fruit is sour, sweet and delicious, and has the reputation of 'gold fruit'. Raspberry is rich in salicylic acid, phenolic acid, etc. Salicylic acid is called natural aspirin, is widely used for easing pain, relieving heat, resisting blood coagulation and effectively preventing thrombus. If the raspberry is eaten for a long time, the heart can be effectively protected, and cardiovascular and cerebrovascular diseases such as hypertension, vascular wall atherosclerosis, cardiovascular and cerebrovascular embrittlement and rupture and the like can be prevented.

The lotus leaf is the leaf of a perennial aquatic herbaceous plant lotus. The chemical components mainly comprise nuciferine, citric acid, malic acid, gluconic acid, oxalic acid, succinic acid and other alkaline components with antimitotic effect. The nuciferine in the lotus leaf tea contains various effective lipid-dissolving alkaloids, can effectively decompose fat in vivo, and can be discharged out of body. Nuciferine can be strongly and densely distributed on the intestinal wall of a human body to form a fat isolation membrane to prevent fat absorption and fat accumulation. Can improve greasy dietary habit, and has strong oil and fat rejection effect.

Preferably, the traditional Chinese medicine composition can be compatible with other traditional Chinese medicines, and 1-4 parts of houttuynia cordata, 4-6 parts of pseudo-ginseng flower, 20-23 parts of mint and 5-10 parts of plantain herb are selected, so that the traditional Chinese medicine composition can play a role in treating cold on the basis of the original traditional Chinese medicine composition.

The invention also provides a freeze-dried ultrafine powder processing device, which comprises the following specific scheme:

a freeze-dried superfine powder processing device comprises a first pulverizer, a first auger communicated with a discharge pipe of the first pulverizer, a mixing box communicated with a discharge hole of the first auger, a low-temperature dryer communicated with the mixing box through a mixed liquid pipe, and a second pulverizer communicated with the low-temperature dryer through a freeze-dried powder pipe, wherein a discharge hole of the second pulverizer is also communicated with the second auger, and a discharge hole of the second auger is communicated with a low-temperature storage box through a discharge pipe;

furthermore, the first pulverizer comprises a first shell, a first pulverizing mechanism and a screen, wherein the first pulverizing mechanism and the screen are arranged in the first shell;

the low-temperature dryer is further provided with an air inlet, the air inlet is connected with one end of a first pipeline through a third pipeline, the first pipeline is further connected with an air blower and one end of a second pipeline respectively, the other end of the second pipeline is provided with a third circular ring and is communicated with the inner side of the third circular ring, the third circular ring is sleeved at one end of the rotating column, a ventilation passage is arranged in the rotating column, an air inlet of the ventilation passage is arranged on the rotating column, a plurality of air outlets of the ventilation passage are respectively arranged on the connecting rod, and the inner side of the circular ring is attached to the air inlet;

be provided with pneumatic valve one on the second pipeline, be provided with pneumatic valve two on the third pipeline, the rotation end of auger is connected with spills the material mechanism, it is located to spill the material mechanism the mixing box, spill the material mechanism include one end with the auger is connected and hollow carousel, the carousel with spill the feed cylinder intercommunication, the lateral part of spilling the feed cylinder is provided with a plurality of through-holes that are used for the ejection of compact.

The inner wall of the first auger is an uneven friction surface, so that the medicine can be secondarily crushed in the process of conveying the medicine, the circular ring can be kept still in the rotating process of the rotating column, air flow emitted by the air blower can flow into the circular ring through the second pipeline, and then enters the ventilation passage of the rotating column through the air inlet in the rotating process of the rotating column.

The other end face of the turntable is provided with a first gear in parallel, the first gear is vertically meshed with the side portion of a second gear, the bottom end of the second gear is connected with one end of a connecting column, the side portion of the connecting column is provided with a plurality of stirring rods, the bottom face of one stirring rod is hinged with a cylindrical plug, the cylindrical plug is connected in a strip-shaped groove in a sliding mode, the strip-shaped groove is formed in the top face of a scraper, the scraper is connected with a second sliding rail arranged on the bottom face of the mixing box, and the first gear and the second gear are bevel gears.

First hank dragon rotatory in-process, the gear drives for a moment gear two is rotatory, with the puddler that gear two pass through the spliced pole and connect can take place rotatoryly, the scraper blade is in under the drive of puddler, can be along two reciprocating motion of slide rail, mixed liquid passes through mixed liquid pipe gets into the in-process of low temperature drying machine can with the pipe mouth department that mixed liquid pipe was scraped to a small amount of mixed liquid of mixing box bottom surface can be collected mixed liquid better.

Furthermore, the second pulverizer comprises a second shell and a screen drum arranged on the inner side of the second shell, the outer side of the screen drum is sleeved with the pulverizing drum, one end of the pulverizing drum is provided with a baffle, the baffle is provided with a plurality of through holes, the baffle is connected with a second motor, and the second motor is provided with a third synchronizing wheel;

the grinding mechanism comprises a shell II, a baffle plate I and a grinding plate II, wherein one end of the baffle plate I is arranged in the shell II, the other end of the baffle plate I is connected with a feed inlet of the grinding mechanism, the grinding mechanism comprises a shell III, and a grinding plate I and a grinding plate II which are arranged in the shell III;

the discharge gate of casing three passes through discharging pipe and second auger intercommunication, be provided with the cooling cistern in the axis of rotation of second auger, coolant liquid pipe in the low temperature drying machine with the cooling cistern is connected.

Further, the first crusher is arranged on a support, a first synchronizing wheel is sleeved on the rotating column, a second synchronizing wheel is arranged on the support, the first synchronizing wheel and the second synchronizing wheel are connected through a first transmission belt, a screw rod is connected to the inner side of the first synchronizing wheel and penetrates through the support, a material containing hopper for containing medicines is arranged at the top end of the screw rod, a material blocking plate is arranged on the outer side of the first shell, a first sliding rail is arranged on the material blocking plate, the material containing hopper is connected with the first sliding rail, and a medicine inlet of the first crusher is arranged on the material blocking plate;

the discharge hole downward sloping of flourishing hopper, and with the striker plate laminating.

According to the freeze-dried ultrafine powder processing device, the particles are cooled and dried by the low-temperature dryer and are in a freeze-dried state, and cold air fed by the cooler can ensure that the temperature of the freeze-dried particles is not increased due to the subsequent crushing process, so that the working quality is influenced, and the normal operation of freeze-drying and crushing is ensured.

The invention also provides a processing method of the anoectochilus roxburghii freeze-dried superfine powder, which can be used for preparing the anoectochilus roxburghii freeze-dried superfine powder by the processing device and specifically comprises the following steps:

1. washing Anoectochilus roxburghii with water, removing impurities, and draining;

2. preliminarily crushing the drained anoectochilus roxburghii to 1-2mm of each section;

3. placing anoectochilus roxburghii into a first superfine pulverizer for pulverizing, and sieving the pulverized particles with a sieve of 50-150 meshes;

4. mixing the mixed particles with an antifreezing solution to form a mixed liquid, introducing the mixed liquid into a low-temperature dryer, freezing for 2.5-3.5h at the temperature of-30-15 ℃, and then drying at low temperature to obtain freeze-dried powder;

5. and introducing the freeze-dried powder into a second superfine pulverizer to obtain the freeze-dried superfine powder.

Preferably, in the third step, the anoectochilus formosanus, the rhizoma polygonati, the raspberry, the lotus leaf, the mulberry leaf, the dendrobium officinale, the astragalus membranaceus and the radix puerariae are weighed in proportion and are placed into a first superfine pulverizer to be pulverized. And then, with the operation of the device, the finally obtained freeze-dried superfine powder is mixed freeze-dried superfine powder containing a plurality of traditional Chinese medicines, so that the preparation of the medicines is facilitated.

In order to enable the medicine of the invention to be accepted by more people, the invention also provides a preparation method of the anoectochilus roxburghii freeze-dried superfine powder oral liquid, capsule and granule, and the specific scheme is as follows:

a preparation method of anoectochilus roxburghii freeze-dried superfine powder oral liquid comprises the steps of extracting the mixed freeze-dried superfine powder prepared in the mode, extracting a concentrated solution, compounding the obtained concentrated solution and water in proportion, canning in a sterile environment, and performing anticorrosion and sterilization treatment to obtain the anoectochilus roxburghii compound oral liquid.

A preparation method of a freeze-dried superfine powder capsule of anoectochilus roxburghii comprises the steps of crushing the mixed freeze-dried superfine powder to a screen of 180-220 meshes, and filling the mixed freeze-dried superfine powder into a No. 1 capsule shell under an aseptic condition to obtain a finished capsule product.

A preparation method of freeze-dried superfine powder electuary of Anoectochilus roxburghii comprises the steps of dissolving and mixing mixed freeze-dried superfine powder according to a certain proportion, spraying the mixed solution into a granulation tower for atomization, drying fog drops into granular powder, taking out the granular powder from a drying tower, bagging under the aseptic condition, and completing the packaging of the electuary.

The invention has the following technical effects:

(1) The first pulverizer can perform cleaning and blowing on the inner wall of the first shell in the process of pulverizing medicinal materials, so that adhered medicines fall off, the interior of the first shell is kept clean, and the waste of medicines is reduced;

(2) In the moving process of the first auger, the medicine can be conveyed and secondarily crushed, and the material spraying mechanism can be driven, so that the medicine powder can be scattered and sprayed into the anti-freezing solution, and the phenomenon that a plurality of medicine powder is concentrated and accumulated in the anti-freezing solution to influence the mixing effect is avoided; meanwhile, the first gear drives the second gear to drive the connecting column to rotate under the driving of the first auger, so that the stirring rod can mix and stir the medicines and the antifreeze solution, the scraper blade can scrape the mixed solution on the bottom surface of the mixing box to the mixed solution pipe along the second sliding rail under the rotation of the stirring rod, and the mixed solution can be better collected;

(3) Many pathologies of diabetes are caused by excessive deposition of hepatotoxin and disordered functions, the traditional Chinese medicine raw material provided by the invention takes anoectochilus formosanus as a main component, is matched with other traditional Chinese medicine components, assists the anoectochilus formosanus to play a role in reducing blood sugar, and can effectively alleviate symptoms of diabetes;

(4) The anoectochilus roxburghii oral liquid, capsule and granule provided by the invention not only can reduce blood sugar, but also can restore the function of human pancreas islet, so that the content of human insulin is increased, and diabetes is fundamentally relieved and treated. In addition, researches prove that the anoectochilus formosanus oral liquid, the capsule and the electuary also have the effects of protecting liver, reducing blood pressure, resisting tumor, relieving pain and diminishing inflammation.

Drawings

FIG. 1 is a schematic view showing the structure of a freeze-dried ultrafine powder processing apparatus according to the present invention.

FIG. 2 is a view showing the internal structure of the apparatus for processing lyophilized micropowder according to the present invention.

FIG. 3 is a view showing the structure of the inside of a casing according to the present invention.

FIG. 4 is a schematic view of the connection between the hopper and the first slide rail according to the present invention.

FIG. 5 is a schematic view of the connection between the second pipeline and the ring according to the present invention.

Fig. 6 is a schematic view of an air intake in the present invention.

Fig. 7 is a schematic view of the connection between the ring and the rotating column according to the present invention.

FIG. 8 is a schematic view of the polishing mechanism of the present invention.

FIG. 9 is a schematic view showing the connection between the cooling liquid pipe and the second packing auger according to the present invention.

Fig. 10 is a front view of the interior of the mixing box of the present invention.

Fig. 11 is a partial structural diagram of the present invention.

Wherein the reference numerals are: 1. a first motor; 2. a first shell; 3. a striker plate; 4. a material containing hopper; 5. a second synchronizing wheel; 6. a first transmission belt; 7. a screw; 8. a support; 9. a blower; 10. a first pipeline; 11. a second pipeline; 12. a third pipeline; 13. a first auger; 14. a mixing box; 15. a mixed liquid pipe; 16. a low temperature dryer; 17. a low temperature storage tank; 18. a coolant tube; 19. freeze-drying the powder tube; 20. a second motor; 21. a second transmission belt; 22. a second shell; 23. a second auger; 24. rotating the column; 25. a blade; 26. screening a screen; 27. a turntable; 28. a sprinkling barrel; 29. a screen drum; 30. a grinding cylinder; 31. a baffle plate; 32. a third shell; 33. a circular ring; 34. a medicine inlet; 35. an air outlet; 36. a first slide rail; 37. an air inlet; 38. a first grinding plate; 39. a second grinding plate; 40. a first gear; 41. a second gear; 42. a squeegee; 43. a second slide rail; 44. a stirring rod; 45. connecting columns.

Detailed Description

The invention will be described more fully hereinafter with reference to the accompanying drawings and examples.

Example 1

Referring to fig. 1 and 2, the freeze-dried ultrafine powder processing device comprises a first pulverizer, a first packing auger 13 communicated with a discharge pipe of the first pulverizer, a mixing box 14 communicated with a discharge port of the first packing auger 13, a low-temperature dryer 16 communicated with the mixing box 14 through a mixing liquid pipe 15, and a second pulverizer communicated with the low-temperature dryer 16 through a freeze-dried powder pipe 19, wherein a discharge port of the second pulverizer is also communicated with a second packing auger 23, and a discharge port of the second packing auger 23 is communicated with a low-temperature storage box 17 through a discharge pipe;

referring to fig. 3, the first pulverizer includes a first housing 2, a first pulverizing mechanism and a screen 26, the first pulverizing mechanism includes a rotating column 24 and a plurality of connecting rods arranged on the rotating column 24, the connecting rods are provided with a plurality of blades 25, and one end of the rotating column 24 is connected with a first motor 1;

referring to fig. 5, 6 and 7, the low temperature dryer 16 is further provided with an air inlet, the air inlet is connected with one end of the first pipeline 10 through a third pipeline 12, the first pipeline 10 is further connected with one end of the blower 9 and one end of the second pipeline 11 respectively, the other end of the second pipeline 11 is provided with a third circular ring 33 and is communicated with the inner side of the third circular ring 33, the third circular ring 33 is sleeved at one end of the rotating column 24, a ventilation passage is arranged in the rotating column 24, an air inlet 37 of the ventilation passage is arranged on the rotating column 24, a plurality of air outlets 35 of the ventilation passage are respectively arranged on the connecting rod, and the inner side of the circular ring 33 is attached to the air inlet;

the first air valve is arranged on the second pipeline 11, the second air valve is arranged on the third pipeline 12, the rotating end of the packing auger is connected with the material sprinkling mechanism, the material sprinkling mechanism is located in the mixing box 14 and comprises a hollow rotary table 27, one end of the rotary table 27 is connected with the packing auger, the rotary table 27 is communicated with the material sprinkling cylinder 28, and a plurality of through holes for discharging are formed in the side portion of the material sprinkling cylinder 28.

The other end face of the rotating disc 27 is provided with a first gear 40 in parallel, the first gear 40 is vertically meshed with the side portion of a second gear 41, the bottom end of the second gear 41 is connected with one end of a connecting column 45, the side portion of the connecting column 45 is provided with a plurality of stirring rods 44, the bottom surface of one stirring rod 44 is hinged with a cylindrical plug, the cylindrical plug is slidably connected in a strip-shaped groove, the strip-shaped groove is arranged on the top surface of a scraping plate 42, the scraping plate 42 is connected with a second sliding rail 43 arranged on the bottom surface of the mixing box 14, and the first gear 40 and the second gear 41 are bevel gears.

The second pulverizer comprises a second shell 22 and a screen cylinder 29 arranged on the inner side of the second shell 22, the outer side of the screen cylinder 29 is sleeved with a pulverizing cylinder 30, one end of the pulverizing cylinder 30 is provided with a baffle plate 31, the baffle plate 31 is provided with a plurality of through holes, the baffle plate 31 is connected with a second motor 20, and a third synchronizing wheel is arranged on the second motor 20;

referring to fig. 8, the second casing 22 is further provided with a collecting pipe, one end of the collecting pipe is located between the baffle 31 and the second motor 20, the other end of the collecting pipe is connected with a feed inlet of the grinding mechanism, the grinding mechanism comprises a third casing 32, a first grinding plate 38 and a second grinding plate 39, the first grinding plate 38 and the second grinding plate 39 are arranged in the third casing 32, the end of the first grinding plate 38 is connected with a fourth synchronizing wheel through a connecting shaft, the fourth synchronizing wheel and the third synchronizing wheel are connected through a second driving belt 21, the end faces and the side portions of the first grinding plate 38 and the second grinding plate 39 are both attached to the inner side of the third casing 32, and the inner side of the third casing 32 is a grinding face for grinding;

referring to fig. 9, the discharge hole of the third casing 32 is communicated with the second packing auger 23 through a discharge pipe, a cooling liquid tank is arranged in the rotating shaft of the second packing auger 23, and a cooling liquid pipe 18 in the low-temperature dryer 16 is connected with the cooling liquid tank.

Referring to fig. 4, a first crusher is arranged on a support 8, a first synchronizing wheel is sleeved on a rotating column 24, a second synchronizing wheel 5 is arranged on the support 8, the first synchronizing wheel and the second synchronizing wheel 5 are connected through a first driving belt 6, a screw rod 7 is connected to the inner side of the first synchronizing wheel, the screw rod 7 penetrates through the support 8, a material containing hopper 4 for containing medicines is arranged at the top end of the screw rod, a material baffle plate 3 is arranged on the outer side of a first shell 2, a first sliding rail 36 is arranged on the material baffle plate 3, the material containing hopper 4 is connected with the first sliding rail 36, and a medicine inlet 34 of the first crusher is arranged on the material baffle plate 3;

the discharge hole of the material containing hopper 4 is inclined downwards and is attached to the material baffle 3.

The working principle of the device is as follows:

traditional Chinese medicine materials such as anoectochilus formosanus are placed in the material containing hopper 4, the baffle plate 3 is attached to a discharge port of the material containing hopper 4, the medicinal materials can be prevented from falling, then the motor I1 is started, the motor I1 can drive the rotating column 24 in the shell I2 to rotate, a plurality of blades 25 on the connecting rod can rotate and cut the medicinal materials, preliminary crushing is carried out, the synchronizing wheel I sleeved on the rotating column 24 drives the synchronizing wheel II 5 to rotate through the driving belt I6, relative rotation is carried out between the synchronizing wheel II 5 and the screw 7, the screw 7 is lifted under the rotation of the synchronizing wheel, the material containing hopper 4 arranged on the screw 7 is lifted along the sliding rail I36, and when the discharge port of the material containing hopper 4 is communicated with the medicine inlet 34 of the shell I2, the medicinal materials can enter the shell I2;

preferably, the lower part of the screw 7 is a smooth surface without threads, so that the screw 7 cannot be in a rising state all the time, the proper screw 7 can be selected during operation, when the feeding hole of the material containing hopper 4 is communicated with the medicine inlet 34 of the first shell 2, the screw 7 just rises to the highest position, and the screw 7 cannot rise or fall due to the synchronous wheel and the smooth surface below the screw 7.

When the medicinal material was smashed at casing one 2, had partial medicinal material piece adhesion on the inner wall of casing one 2, opened air-blower 9 and pneumatic valve one this moment, closed pneumatic valve two, air-blower 9's air current can enter into along with pipeline two 11 in the rotation post 24, then blow off from the tip of connecting rod, will adhere the medicinal material on casing one 2 and blow off, guaranteed the cleanness in the casing one 2, also guaranteed the utilization ratio of medicinal material.

The medicine enters the first auger 13 through the screen 26, the screen 26 can separate out larger particles and crush the larger particles together with the later medicinal materials, the primarily crushed medicine is conveyed into the mixing box 14 by the first auger 13, and the inner wall of the first auger 13 is an uneven friction surface and can be crushed for the second time in the process of conveying the medicine;

the first auger 13 sends the medicines into the rotary table 27 through the through hole on the rotary table 27, then the powdery medicines are thrown into the sprinkling cylinder 28 under the rotation of the first auger 13 and are sprinkled into the antifreeze solution through the through hole on the sprinkling cylinder 28, the sprinkling mechanism prevents the medicines from intensively dropping into a certain area of the antifreeze solution, the medicines and the antifreeze solution are prevented from being fully mixed, and the sprinkling cylinder 28 continuously rotates under the drive of the first auger 13 to spill the medicine powder;

at this time, the first gear 40 drives the second gear 41 to rotate, the connecting column 45 connected with the second gear 41 drives the stirring rods 44 to rotate, so as to stir and mix the medicine powder and the antifreeze solution, the scraper 42 reciprocates along the second sliding rail 43 under the rotation of one of the stirring rods 44, the mixed solution flows into the low-temperature dryer 16 through the mixed solution pipe 15, preferably, the mixed solution pipe 15 can be provided with an electric pump, so that the mixed solution can be pumped into the low-temperature dryer 16, and part of the mixed solution remaining on the bottom surface of the mixing box 14 is scraped to the vicinity of the pipe orifice of the mixed solution pipe 15 under the scraping action of the scraper 42, and is pumped into the mixed solution pipe 15 under the action of the electric pump, so that the waste of the mixed solution is reduced;

the low-temperature dryer 16 freezes the medicines, then performs low-temperature drying, most of moisture in the medicines volatilizes to enable the medicines to form freeze-dried powder, then closes the first air valve, opens the second air valve, blows the freeze-dried powder into the screen cylinder 29 in the second pulverizer through the blower 9, the freeze-dried powder with proper particle size passes through the screen cylinder 29 and is blown into the pulverizing cylinder 30 through air flow, the second motor 20 drives the pulverizing cylinder 30 to rotate, a plurality of collision blocks are arranged in the pulverizing cylinder 30 in the embodiment, the freeze-dried powder can be pulverized again after colliding with the collision blocks, then passes through the through holes in the baffle plate 31 to enter the collecting pipe and then flows into the third shell 32 of the grinding mechanism, and the number of the grinding mechanisms in the embodiment is two;

the second motor 20 can drive the first grinding plate 38 to rotate through the second transmission belt 21, the freeze-dried powder entering the third shell 32 can be ground into freeze-dried superfine powder again under the rotation of the first grinding plate 38 and falls into the second packing auger 23, the cooling liquid tank in the second packing auger 23 can be filled with cooling liquid, the freeze-dried superfine powder heated due to grinding can be cooled in the process of conveying the freeze-dried superfine powder, and then the freeze-dried superfine powder can be conveyed into the low-temperature storage box 17 for storage.

Example 2

The anoectochilus formosanus freeze-dried ultramicro powder oral liquid comprises traditional Chinese medicine raw materials and water, wherein the traditional Chinese medicine raw materials comprise the following components in parts by weight: 50 parts of anoectochilus roxburghii, 7 parts of rhizoma polygonati, 10 parts of raspberry, 5 parts of lotus leaf, 5 parts of mulberry leaf, 8 parts of dendrobium officinale, 10 parts of astragalus membranaceus and 5 parts of kudzu root.

The preparation method comprises the following steps:

3. weighing anoectochilus roxburghii, rhizoma polygonati, raspberry, lotus leaf, mulberry leaf, dendrobium officinale, astragalus and radix puerariae according to a proportion, putting the anoectochilus roxburghii, rhizoma polygonati, raspberry, lotus leaf, mulberry leaf, dendrobium officinale, astragalus and radix puerariae into a first superfine pulverizer for pulverization, and then sieving the pulverized particles with a sieve of 50-150 meshes;

5. and introducing the freeze-dried powder into a second superfine pulverizer to obtain the mixed freeze-dried superfine powder.

6. Extracting the mixed freeze-dried ultrafine powder prepared in the manner to obtain a concentrated solution, compounding the obtained concentrated solution with water in proportion, canning in an aseptic environment, and performing anticorrosion and sterilization treatment to obtain the anoectochilus formosanus compound oral liquid.

Example 3

The roxburgh anoectochilus terminal bud freeze-dried superfine powder capsule comprises traditional Chinese medicine raw materials which comprise the following components in parts by weight: 50 parts of anoectochilus roxburghii, 7 parts of rhizoma polygonati, 10 parts of raspberry, 5 parts of lotus leaf, 5 parts of mulberry leaf, 8 parts of dendrobium officinale, 10 parts of astragalus membranaceus and 5 parts of kudzu root.

The preparation method comprises the following steps:

2. preliminarily crushing the drained anoectochilus roxburghii to each section of 1-2mm;

3. weighing anoectochilus roxburghii, rhizoma polygonati, raspberry, lotus leaves, mulberry leaves, dendrobium officinale, astragalus membranaceus and radix puerariae according to a proportion, putting the anoectochilus roxburghii, rhizoma polygonati, raspberry, lotus leaves, folium mori, radix astragali and radix puerariae into a first superfine pulverizer for pulverization, and then sieving the pulverized particles with a sieve of 50-150 meshes;

4. mixing the mixed particles with an antifreeze solution to form a mixed liquid, introducing the mixed liquid into a low-temperature dryer, freezing for 2.5-3.5h at the temperature of-30-15 ℃, and then drying at low temperature to obtain freeze-dried powder;

6. And crushing the mixed freeze-dried ultrafine powder to pass through a 180-220-mesh sieve, and filling the mixed freeze-dried ultrafine powder into a No. 1 capsule shell under an aseptic condition to obtain a capsule finished product.

Example 4

Anoectochilus roxburghii freeze-dried ultrafine powder electuary comprises traditional Chinese medicine raw materials and water, wherein the traditional Chinese medicine raw materials comprise: 50 parts of anoectochilus roxburghii, 7 parts of rhizoma polygonati, 10 parts of raspberry, 5 parts of lotus leaf, 5 parts of mulberry leaf, 8 parts of dendrobium officinale, 10 parts of astragalus membranaceus and 5 parts of kudzu root.

The preparation method comprises the following steps:

6. Dissolving and mixing the mixed freeze-dried superfine powder and water according to a certain proportion, spraying the mixed solution into a granulation tower for atomization, drying fog drops into granular powder, taking out the granular powder from a drying tower, and bagging under an aseptic condition to finish the packaging of the granules.

Experimental example 1

The oral liquid of the present invention is used as an example of a treatment for 90 patients with type II diabetes.

1. Patient data

In this group, 49 men and 41 women; age 38-55 years old; the course of the disease is 9 months to 10 years. 13 cases of concurrent peripheral neuropathy, 4 cases of retinopathy at early stage, 3 cases of second stage and 18 cases of coronary heart disease.

2. Method of treatment

When 90 cases are treated by using the medicine provided by the invention, 150ml is taken daily half an hour before three meals, 1 month is 1 course of treatment, and the curative effect is observed after 6 courses of treatment. Sugar tolerance and 24-hour urine glucose test were performed 1 time per month.

3. Therapeutic effects

The total number of clinical samples in the group is 90, 10 patients are cured after treatment, 39 patients have obvious effect, 32 patients have effect, and the total effective rate is 90%. Most complications are improved to varying degrees: peripheral nerve symptoms disappeared in 10 cases and alleviated in 4 cases; 2 cases of retinopathy disappear, and 1 case of retinopathy improves in the second stage; improvement appears in 9 cases of coronary heart disease.

The medicine contains various medical components, and can improve and solve various problems in the body of a patient: the anoectochilus formosanus polysaccharide can improve liver and islet tissues in a human body, enhance the insulin secretion capacity, increase the insulin content in serum and obviously reduce the sugar level in the human body; the raspberry components can effectively protect the heart and prevent cardiovascular and cerebrovascular diseases such as hypertension, vascular wall atherosclerosis, cardiovascular and cerebrovascular embrittlement and rupture and the like; the saponins in the anoectochilus formosanus and the polygonatum sibiricum can be combined with uric acid in a human body and purine substances, so that acidic substances in the uric acid are metabolized out of the body, and the gout solving effect is achieved; the lotus leaf contains various fat-reducing alkaloids, which can effectively decompose fat in vivo and discharge the fat out of the body, and the nuciferine can be densely distributed on the intestinal wall of a human body to form a fat isolating membrane, so that fat absorption is prevented, fat accumulation is prevented, metabolism of the body is improved, and the slimming effect is achieved.

The anoectochilus formosanus contains a large amount of flavone, anoectochilus formosanus polysaccharides, taurine, anoectochilus formosanus glycoside and other components, has the effects of nutrition, aging resistance and organism immunity regulation, particularly has the effect of removing free radicals, and has very obvious treatment effect on various diseases such as hand-foot-mouth disease and the like.

The above embodiments are only preferred embodiments of the present invention, and do not represent limitations to the scope of the invention, so the scope of the present invention is not limited to the above embodiments and drawings, and any modifications, equivalent substitutions, improvements and the like within the spirit and principle of the present invention should be included in the scope of the present invention.

Claims

1. The anoectochilus formosanus compound traditional Chinese medicine raw material is characterized by comprising the following components in parts by weight: 45-55 parts of anoectochilus roxburghii, 5-10 parts of rhizoma polygonati, 5-15 parts of raspberry, 3-10 parts of lotus leaf, 3-10 parts of mulberry leaf, 5-10 parts of dendrobium officinale, 7-13 parts of astragalus mongholicus and 3-7 parts of radix puerariae.

2. The compound traditional Chinese medicine raw material as claimed in claim 2, which comprises the following components in parts by weight: 50 parts of anoectochilus roxburghii, 7 parts of rhizoma polygonati, 10 parts of raspberry, 5 parts of lotus leaf, 5 parts of mulberry leaf, 8 parts of dendrobium officinale, 10 parts of astragalus membranaceus and 5 parts of radix puerariae.

3. A processing method of freeze-dried superfine powder of anoectochilus roxburghii is characterized by comprising the following steps:

step S1: washing Anoectochilus roxburghii with water, removing impurities, and draining;

step S2: preliminarily crushing the drained anoectochilus roxburghii to 1-2mm of each section;

and step S3: placing anoectochilus roxburghii into a first superfine pulverizer for pulverizing, and sieving the pulverized particles with a sieve of 50-150 meshes;

and step S4: mixing the mixed particles with an antifreezing solution to form a mixed liquid, introducing the mixed liquid into a low-temperature dryer, freezing for 2.5-3.5h at the temperature of-30-15 ℃, and then drying at low temperature to obtain freeze-dried powder;

step S5: and introducing the freeze-dried powder into a second superfine pulverizer to obtain the freeze-dried superfine powder.

4. The processing method of the freeze-dried ultrafine powder as claimed in claim 3, wherein in the third step, anoectochilus roxburghii, polygonatum sibiricum, rubi fructus, nelumbo nucifera leaf, morus alba leaf, dendrobium officinale Kimura, astragalus membranaceus and Pueraria lobata are weighed in proportion and put into the first ultrafine pulverizer to be pulverized.

5. A freeze-dried ultra-fine powder processing device is characterized by comprising a first grinder, a first auger (13) communicated with a discharge pipe of the first grinder, a mixing box (14) communicated with a discharge hole of the first auger (13), a low-temperature dryer (16) communicated with the mixing box (14) through a mixed liquid pipe (15), and a second grinder communicated with the low-temperature dryer (16) through a freeze-dried powder pipe (19), wherein a discharge hole of the second grinder is also communicated with a second auger (23), and a discharge hole of the second auger (23) is communicated with a low-temperature storage box (17) through a discharge pipe;

the first pulverizer comprises a first shell (2), a first pulverizing mechanism and a screen (26), wherein the first pulverizing mechanism is arranged in the first shell (2), the first pulverizing mechanism comprises a rotating column (24) and a plurality of connecting rods arranged on the rotating column (24), a plurality of blades (25) are arranged on the connecting rods, and one end of the rotating column (24) is connected with a first motor (1);

the low-temperature dryer (16) is further provided with an air inlet, the air inlet is connected with one end of a first pipeline (10) through a third pipeline (12), the first pipeline (10) is further connected with one end of an air blower (9) and one end of a second pipeline (11) respectively, the other end of the second pipeline (11) is provided with a circular ring (33) and communicated with the inner side of the circular ring (33), the circular ring (33) is sleeved at one end of the rotating column (24), a ventilation passage is arranged in the rotating column (24), an air inlet (37) of the ventilation passage is arranged on the rotating column (24), a plurality of air outlets (35) of the ventilation passage are arranged on the connecting rod respectively, and the inner side of the circular ring (33) is attached to the air inlet;

be provided with pneumatic valve one on pipeline two (11), be provided with pneumatic valve two on pipeline three (12), the rotation end and the unrestrained material mechanism of first hank dragon (13) are connected, unrestrained material mechanism is located in mixing box (14), unrestrained material mechanism include one end with first hank dragon (13) are connected and hollow carousel (27), carousel (27) and unrestrained feed cylinder (28) intercommunication, the lateral part of unrestrained feed cylinder (28) is provided with a plurality of through-holes that are used for the ejection of compact.

The other end face of the rotary disc (27) is provided with a first gear (40) in parallel, the first gear (40) is vertically meshed with the side portion of a second gear (41), the bottom end of the second gear (41) is connected with one end of a connecting column (45), a plurality of stirring rods (44) are arranged on the side portion of the connecting column (45), the bottom face of one stirring rod (44) is hinged with a cylindrical plug, the cylindrical plug is connected in a strip groove in a sliding mode, the strip groove is formed in the top face of a scraper (42), the scraper (42) is connected with a second sliding rail (43) arranged on the bottom face of the mixing box (14), and the first gear (40) and the second gear (41) are bevel gears.

6. The processing device of the freeze-dried superfine powder as claimed in claim 5, wherein the second pulverizer comprises a second casing (22) and a screen cylinder (29) arranged at the inner side of the second casing (22), the outer side of the screen cylinder (29) is sleeved with a pulverizing cylinder (30), one end of the pulverizing cylinder (30) is provided with a baffle plate (31), the baffle plate (31) is provided with a plurality of through holes, the baffle plate (31) is connected with a second motor (20), and the second motor (20) is provided with a third synchronizing wheel;

the second shell (22) is further provided with a collecting pipe, one end of the collecting pipe is located between the baffle (31) and the second motor (20), the other end of the collecting pipe is connected with a feed inlet of a grinding mechanism, the grinding mechanism comprises a third shell (32), a first grinding plate (38) and a second grinding plate (39) which are arranged in the third shell (32), the end part of the first grinding plate (38) is connected with a fourth synchronizing wheel through a connecting shaft, the fourth synchronizing wheel is connected with the third synchronizing wheel through a second driving belt (21), the end surfaces and the side parts of the first grinding plate (38) and the second grinding plate (39) are attached to the inner side of the third shell (32), and the inner side of the third shell (32) is a grinding surface for grinding;

the discharge gate of the third casing (32) is communicated with the second packing auger (23) through the discharge pipe, a cooling liquid tank is arranged in the rotating shaft of the second packing auger (23), and a cooling liquid pipe (18) in the low-temperature dryer (16) is connected with the cooling liquid tank.

7. The processing device of the freeze-dried superfine powder, according to claim 6, characterized in that the first pulverizer is arranged on a support (8), a first synchronizing wheel is sleeved on the rotating column (24), a second synchronizing wheel (5) is arranged on the support (8), the first synchronizing wheel and the second synchronizing wheel (5) are connected through a first transmission belt (6), a screw (7) is connected to the inner side of the first synchronizing wheel, the screw (7) penetrates through the support (8), a material containing hopper (4) for containing medicines is arranged at the top end of the screw, a material baffle plate (3) is arranged on the outer side of the first shell (2), a first sliding rail (36) is arranged on the material baffle plate (3), the material containing hopper (4) is connected with the first sliding rail (36), and a medicine inlet (34) of the first pulverizer is arranged on the material baffle plate (3);

the discharge hole of the material containing hopper (4) is downwards inclined and is attached to the striker plate (3).

8. A preparation method of an oral liquid using the freeze-dried superfine powder of anoectochilus roxburghii as claimed in claim 4 is characterized in that the mixed freeze-dried superfine powder prepared in the manner is extracted to obtain a concentrated solution, the obtained concentrated solution is compounded with water in proportion, the mixture is canned in an aseptic environment, and then the preservative and sterilization treatment are carried out to obtain the compound oral liquid of anoectochilus roxburghii.

9. A preparation method of a capsule using the freeze-dried superfine powder of anoectochilus roxburghii as claimed in claim 4 is characterized in that the mixed freeze-dried superfine powder is crushed to pass through a 180-220 mesh sieve, and then the mixed freeze-dried superfine powder is filled into a No. 1 capsule shell under an aseptic condition to obtain a finished capsule.

10. A preparation method of granules using the freeze-dried superfine powder of anoectochilus roxburghii as claimed in claim 4 is characterized in that the mixed freeze-dried superfine powder is dissolved and mixed according to a certain proportion, then the mixed solution is sprayed into a granulation tower for atomization, fog drops are dried into granular powder, then the granular powder is taken out from the drying tower and packaged under aseptic condition, and the granules are packaged.