Summary of the invention
The present invention provides a kind of Chinese medicine composition (being Chinese patent medicine) for the treatment of pulmonary carcinoma and preparation method thereof.This Chinese patent medicine has the function of supplementing QI and nourishing YIN, blood circulation promoting and blood stasis dispelling, detoxicating and resolving stagnation of pathogens, reinforcing kidney and strengthening resistance, can be used for the treatment of lung bronchogenic carcinoma, and toxic and side effects is little, and steady quality is reliable, and not only clinical practice is safe and effective, and sanitation and hygiene, long shelf-life, easy to carry.
A kind of Chinese medicine composition (being Chinese patent medicine) for the treatment of pulmonary carcinoma of the present invention, it is characterized in that: the percentage by weight for preparing this Chinese patent medicine raw material components is: Radix Polygoni Multiflori Preparata 12%~19%; Radix Notoginseng 4%~9%; Bulbus Fritillariae Thunbergii 5%~8%; Fructus Trichosanthis 6%~9%; Semen Persicae (parched) 4%~9%; Eupolyphaga Seu Steleophaga 5%~9%; Radix Ginseng Rubra 6%~9%; Folium Isatidis 7%~15%; Radix Sophorae Tonkinensis 6%~9%; Poria 6%~9%; Semen Descurainiae (parched) 6%~9%; Pericarpium Citri Reticulatae 6%~9%; Dosage form is oral liquid or is granule or capsule or powder or pill or tablet.
" Radix Polygoni Multiflori Preparata " in the component is Main Ingredients and Appearance of the present invention, because Radix Polygoni Multiflori Preparata contains anthraquinone analog compound, wherein emodin, chrysophanic acid and chrysophanol have significant inhibitory effect to many strains cancerous cell, and be the strongest with the effect of emodin; Its decocting liquid has defying age, effects such as raise immunity.
" Radix Notoginseng " in the component contains multiple and similar composition of ginsenoside and arasaponin R
1, R
2, R
3, R
4, R
6, total saponin content can reach more than 4%.Radix Notoginseng total arasaponins has enhancing human body immunity function and delaying senility function, ginsenoside R
B1, R
d, R
e, R
g, R
hHas antitumaous effect.
" Radix Ginseng Rubra " in the component is the cultivar of Radix Ginseng, the dry root and rhizome after steaming, and contained chemical constituent has 12 classes by structure type, and ginseng saponin most importantly is as R
B1, R
B2, R
d, R
e, R
f, R
G1, R
hWith ginseng polysaccharide etc.; The ginseng polysaccharide has antitumaous effect, and the ginsenoside can make cancerous cell break up again, induces to reverse to be non-cancerous cell, and ginsenoside and polysaccharide also have raise immunity, function in delaying senility.
" Bulbus Fritillariae Thunbergii " in the component mainly contains different steroid alkaloid; Peimine, peiminine, (-)-Zhebeinine, Bulbus Fritillariae Thunbergii ketone, zhebeirine, peminoside etc. are the important composition of hard masses softening and resolving.
" Fructus Trichosanthis " in the component contains triterpenoid saponin, organic acid (Palmic acid, cerinic acid, Melissic Acid etc.) and a small amount of volatile oil.The fatty oil of seed is about 26%, and wherein unsaturated fatty acid accounts for 66.5%, based on trichosanic acid; Protein content is about 5.46% in the seed.Fructus Trichosanthis also contains several amino acids and trace element.The Fructus Trichosanthis decoct has cancer suppressing action; Fructus Trichosanthis is amino acid contained good phlegm-dispelling functions.
" Semen Descurainiae (parched) " in the component is the dry mature seed of crucifer Lepidium sativum L. Lepidium aptalum Wil1d., removes impurity and ash bits, fries method according to an appendix II of Chinese Pharmacopoeia version in 2005 D, fries to detonans is arranged, and takes out, cool.Contain benzyl isothiocyanate, sinalbin, sinigrin, fatty oil and saccharide.The Semen Descurainiae (parched) extract has antitumaous effect.
Be " Semen Persicae (parched) " in the component the dry mature seed of rosaceous plant peach Prunus persica (L.) Batschr, removes impurity, according to an appendix II of Chinese Pharmacopoeia version in 2005 D? the method peeling is dried; Fry to yellow according to an appendix II of Chinese Pharmacopoeia version in 2005 the D method of frying again, take out, cool.Contain amygdalin and prunasin, also contain flavone and glucoside thereof, as nimbecetin and glycoside thereof, Dihydrokaempferol, quercetin glucoside etc.; Steroidal and glycoside thereof, liposome and several amino acids, protein.The hydrolyzate HCN and the benzaldehyde of amygdalin have collaborative destruction to cancerous cell.
" Eupolyphaga Seu Steleophaga " main component in the component is 17 seed amino acids, and what content was higher has: glutamic acid 4.84%, alanine 3.42%, tyrosine 3.33%, Aspartic Acid 3.23%; 28 kinds of trace element such as manganese, zinc, selenium etc.Also contain sterol and straight chain aliphatic compound, it is alkaloidal to report that in addition Eupolyphaga Seu Steleophaga contains, but becomes to be hard to tell.Eupolyphaga Seu Steleophaga decocting liquid has antimutagenic effect.
" Folium Isatidis " in the component mainly contains indirubin, indigo, Isatan B, glucobrassicin, neoglucobrassicin, gland glycoside, also contains compositions such as cupreol, clionasterol, aminoacid and sugar.Indirubin has significant inhibitory effect to many strains cancerous cell.
" Radix Sophorae Tonkinensis " in the component mainly contains alkaloid and flavone, and alkaloid has: sophocarpine, matrine, oxymatrine, anagyrine, methylcytisine, N-oxysophocarpine, dauricine and Radix Sophorae Tonkinensis glycol.Flavone has: sophoranone, sophoradin, sophoradochromene, genistein etc.Radix Sophorae Tonkinensis decocting liquid has cancer suppressing action, and matrine and oxymatrine have the effect of leukocyte increasing.
" Poria " main component in the component is a pachymose, and content is 84.2%, still contains multiple triterpene substances such as pachymic acid, native male acid, loose Siberian cocklebur acid.Also have compositions such as fatty acid, lecithin, cellulose, inorganic salt in addition.Pachyman has significant cancer suppressing action.
" Pericarpium Citri Reticulatae " in the component mainly contains volatile oil, and its chemical constituent has: α one thujene, australene, limonene etc.Can propose in the Pericarpium Citri Reticulatae hesperidin, neohesperidin, naringenin and 5-hydroxyl-6,7,8,3 ', 4 '-the penta hydroxy group Endospermum chinense Benth., 5,6,7,8,4 '-the pentamethoxyl flavone, 5,6,7,8,3 ', 4 '-compositions such as hexa methoxy flavone.Modern pharmacological research proves, Pericarpium Citri Reticulatae has boosting, antiplatelet aggregative activity, the activity of the ptyalin that exsomatizes is had obvious facilitation, prolongs life span of drosophila melanogaster and strengthens its flight performance. improve fruit bat head part S OD activity.And the effect of reduction lipid oxide content.
One of preparation method of a kind of Chinese patent medicine for the treatment of pulmonary carcinoma of the present invention, the preparation of granule the steps include:
The first step, batching: weighing by weight percentage, Radix Polygoni Multiflori Preparata 12%~19%; Radix Notoginseng 4%~9%; Bulbus Fritillariae Thunbergii 5%~8%; Fructus Trichosanthis 6%~9%; Semen Persicae (parched) 4%~9%; Eupolyphaga Seu Steleophaga 5%~9%; Radix Ginseng Rubra 6%~9%; Folium Isatidis 7%~15%; Radix Sophorae Tonkinensis 6%~9%; Poria 6%~9%; Semen Descurainiae (parched) 6%~9%; Pericarpium Citri Reticulatae 6%~9%;
Second step, extract the volatile oil of Pericarpium Citri Reticulatae and Fructus Trichosanthis: with Pericarpium Citri Reticulatae, the Fructus Trichosanthis that takes by weighing, adopt vapor distillation method to extract volatile oil, be about to medical material and place the multipotency extraction pot, 8~10 times the water logging bubble that adds Pericarpium Citri Reticulatae and Fructus Trichosanthis weight is after 30 minutes, and straight-through Steam Heating proposes volatile oil, collect volatile oil by " oil water separator ", standby; Its medical filtration is collected with container in addition, and is standby; Medicinal residues enter the operation decocting of back and carry;
The 3rd step, the active ingredient of extraction Radix Ginseng Rubra, Radix Notoginseng, Folium Isatidis: adopt " alcohol heat reflux method " to extract.The Radix Ginseng Rubra that is about to take by weighing, Radix Notoginseng, Folium Isatidis are put in the multipotency extraction pot, 60~80% ethanol that add 6~10 times of Radix Ginseng Rubra, Radix Notoginseng, Folium Isatidis weight, after the logical Steam Heating boiling of interlayer, clock, and control jacket steam amount 0.01~0.03Kpa is to little boiling, stop heating after 90 minutes, filter, collect filterable alcohol reflux liquid and use containers store standby in addition; Medicinal residues add 60~80% ethanol of 6~10 times of its weight as stated above again, and filtrate is extracted, filters, collected to same procedure, carry out so altogether 3 times, and after alcohol reflux liquid was collected and finished, medicinal residues entered down the operation decocting and carry;
The 4th step, decocting is carried: medicinal residues and the Radix Polygoni Multiflori Preparata that takes by weighing, Bulbus Fritillariae Thunbergii, Semen Descurainiae (parched), Semen Persicae (parched), Eupolyphaga Seu Steleophaga, Radix Sophorae Tonkinensis, the Poria of second step and three-procedure are merged, place the multipotency extraction pot, add the water of 10 times of weight, soaked 60 minutes, decoct 3 times, each 60 minutes, merge 3 times decocting liquid, filter, the medicinal liquid of the filtrate and the second step operation merges, for operation is concentrated down;
The 5th step, medicinal liquid concentrates: in the alcohol reflux liquid suction concentration tank that three-procedure is obtained, the decompression of unlatching vacuum valve, open steam valve heating recovery ethanol to complete substantially, " medicinal liquid " with the 4th step operation merges again, place the triple effect concentration tank altogether, open the steam valve heating, to relative density of medicine liquid be 1.05~1.15; When fluid temperature is 60 ℃, detect relative density with gravimeter;
In the 6th step, spray drying: the concentrated medicament that the 5th step operation is obtained places storage tank, opens vacuum and heating unit, and it is sprayed in the drying tower, collects dry thing, promptly gets extract powder;
The 7th step, granulate: the dextrin of getting above-mentioned extract powder and 1/2~2/3 " medical material weight ", after placing the one-step-granulating method mix homogeneously, slowly 1/3~1/2 of spraying adding extract powder and dextrin gross weight 20%~30% ethanol liquid is made binding agent, and employing Steam Heating, after treating grain forming, stop spray and add binding agent, continue heat drying to moisture content and be lower than 2%;
In the 8th step, granulate: with granulated material of the 7th step, remove fine powder and granule with 80 mesh sieves sieve, reuse 10 mesh sieves sieve removes coarse grain, collects 80~10 order granules;
In the 9th step, mix: the volatile oil spraying that extraction is obtained adds in the granule that the 8th step obtained by spraying, and it is first mixed spray earlier on one side, puts and mixes 10~15 minutes in the batch mixer;
In the tenth step, qualified granule is got in packing, and with the packing of granule racking machine, loading amount is every bag 5 gram, promptly makes granule.
Two of a kind of Chinese patent medicine preparation method for the treatment of pulmonary carcinoma of the present invention, the preparation of oral liquid the steps include:
The first step, batching: weighing by weight percentage, Radix Polygoni Multiflori Preparata 12%~19%; Radix Notoginseng 4%~9%; Bulbus Fritillariae Thunbergii 5%~8%; Fructus Trichosanthis 6%~9%; Semen Persicae (parched) 4%~9%; Eupolyphaga Seu Steleophaga 5%~9%; Radix Ginseng Rubra 6%~9%; Folium Isatidis 7%~15%; Radix Sophorae Tonkinensis 6%~9%; Poria 6%~9%; Semen Descurainiae (parched) 6%~9%; Pericarpium Citri Reticulatae 6%~9%;
Second step, the volatile oil of extraction Pericarpium Citri Reticulatae and Fructus Trichosanthis:, adopt vapor distillation method to extract volatile oil with Pericarpium Citri Reticulatae, the Fructus Trichosanthis that takes by weighing, be about to medical material and place the multipotency extraction pot, 8~10 times the water logging bubble that adds Pericarpium Citri Reticulatae and Fructus Trichosanthis weight is after 30 minutes, and straight-through Steam Heating proposes volatile oil; Collect volatile oil by " oil water separator ", standby; Its medical filtration is collected with container in addition, and is standby; Medicinal residues enter the 4th step operation decocting and carry;
The 3rd step, the active ingredient of extraction Radix Ginseng Rubra, Radix Notoginseng, Folium Isatidis: adopt " alcohol heat reflux method " to extract.The Radix Ginseng Rubra that is about to take by weighing, Radix Notoginseng, Folium Isatidis are put in the multipotency extraction pot, 60~80% ethanol that add 6~10 times of Radix Ginseng Rubra, Radix Notoginseng, Folium Isatidis weight, after the logical Steam Heating boiling of interlayer, clock, and control jacket steam amount 0.01~0.03Mpa is to little boiling, stop heating after 90 minutes, filter, collect filterable alcohol reflux liquid and use containers store standby in addition; Medicinal residues add 60~80% ethanol of 6~10 times of its weight as stated above again, and filtrate is extracted, filters, collected to same procedure, carry out so altogether 3 times, and after alcohol reflux liquid was collected and finished, medicinal residues entered down the operation decocting and carry;
The 4th step, decocting is carried: medicinal residues and the Radix Polygoni Multiflori Preparata that takes by weighing, Bulbus Fritillariae Thunbergii, Semen Descurainiae (parched), Semen Persicae (parched), Eupolyphaga Seu Steleophaga, Radix Sophorae Tonkinensis, the Poria of second step and three-procedure are merged, place the multipotency extraction pot, add the water of 10 times of weight, soaked 60 minutes, decoct 3 times, each 60 minutes, merge 3 times decocting liquid, filter, the medicinal liquid of the filtrate and the second step operation merges, for operation is concentrated down;
The 5th step, medicinal liquid concentrates: in the alcohol reflux liquid suction concentration tank that three-procedure is obtained, the decompression of unlatching vacuum valve, open steam valve heating recovery ethanol to complete substantially, " medicinal liquid " with the 4th step operation merges again, place the triple effect concentration tank altogether, open the steam valve heating, to relative density of medicine liquid be 1.05~1.15; When fluid temperature is 60 ℃, detect relative density with gravimeter;
In the 6th step, place to filter: after the concentrated medicament that the 5th step operation is obtained is placed 24 hours, filter, it is standby to collect medicinal liquid;
The 7th step, dosing: the second step volatile oil that obtains of operation is added in the medicinal liquid that the 6th step obtained, add the tween of raw material gross weight 1~4% again
80For the protein sugar of solubilizing agent and raw material gross weight 0.5~1.5% is a flavoring agent, stir, promptly make oral liquid.
Three of the preparation method of a kind of Chinese patent medicine for the treatment of pulmonary carcinoma of the present invention, the preparation of capsule the steps include:
The first step, batching: weighing by weight percentage, Radix Polygoni Multiflori Preparata 12%~19%; Radix Notoginseng 4%~9%; Bulbus Fritillariae Thunbergii 5%~8%; Fructus Trichosanthis 6%~9%; Semen Persicae (parched) 4%~9%; Eupolyphaga Seu Steleophaga 5%~9%; Radix Ginseng Rubra 6%~9%; Folium Isatidis 7%~15%; Radix Sophorae Tonkinensis 6%~9%; Poria 6%~9%; Semen Descurainiae (parched) 6%~9%; Pericarpium Citri Reticulatae 6%~9%;
Second step, the volatile oil of extraction Pericarpium Citri Reticulatae and Fructus Trichosanthis:, adopt vapor distillation method to extract volatile oil with Pericarpium Citri Reticulatae, the Fructus Trichosanthis that takes by weighing, be about to medical material and place the multipotency extraction pot, 8~10 times the water logging bubble that adds Pericarpium Citri Reticulatae and Fructus Trichosanthis weight is after 30 minutes, and straight-through Steam Heating proposes volatile oil; Collect volatile oil by " oil water separator ", standby; Its medical filtration is collected with container in addition, and is standby; Medicinal residues enter the 4th step operation decocting and carry;
The 3rd step, the active ingredient of extraction Radix Ginseng Rubra, Radix Notoginseng, Folium Isatidis: adopt " alcohol heat reflux method " to extract.The Radix Ginseng Rubra that is about to take by weighing, Radix Notoginseng, Folium Isatidis are put in the multipotency extraction pot, 60~80% ethanol that add 6~10 times of Radix Ginseng Rubra, Radix Notoginseng, Folium Isatidis weight, after the logical Steam Heating boiling of interlayer, clock, and control jacket steam amount 0.01~0.03Mpa is to little boiling, stop heating after 90 minutes, filter, collect filterable alcohol reflux liquid and use containers store standby in addition; Medicinal residues add 60~80% ethanol of 6~10 times of its weight as stated above again, and filtrate is extracted, filters, collected to same procedure, carry out so altogether 3 times, and after alcohol reflux liquid was collected and finished, medicinal residues entered the 4th step decocting and carry;
The 4th step, decocting is carried: medicinal residues and the Radix Polygoni Multiflori Preparata that takes by weighing, Bulbus Fritillariae Thunbergii, Semen Descurainiae (parched), Semen Persicae (parched), Eupolyphaga Seu Steleophaga, Radix Sophorae Tonkinensis, the Poria of second step and three-procedure are merged, place the multipotency extraction pot, add the water of 10 times of weight, soaked 60 minutes, decoct 3 times, each 60 minutes, merge 3 times decocting liquid, filter, the medicinal liquid of the filtrate and the second step operation merges, for operation is concentrated down;
The 5th step, medicinal liquid concentrates: in the alcohol reflux liquid suction concentration tank that three-procedure is obtained, the decompression of unlatching vacuum valve, open steam valve heating recovery ethanol to complete substantially, " medicinal liquid " with the 4th step operation merges again, place the triple effect concentration tank altogether, open the steam valve heating, to relative density of medicine liquid be 1.05~1.15; When fluid temperature is 60 ℃, detect relative density with gravimeter;
In the 6th step, spray drying: the concentrated medicament that the 5th step operation is obtained places storage tank, opens vacuum and heating unit, and it is sprayed in the drying tower, collects dry thing, promptly gets extract powder;
The 7th step, granulate: the dextrin of getting above-mentioned extract powder and 1/2~2/3 " medical material weight ", after placing the one-step-granulating method mix homogeneously, slowly 1/3~1/2 of spraying adding extract powder and dextrin gross weight 20%~30% ethanol liquid is made binding agent, and employing Steam Heating, after treating grain forming, stop spray and add binding agent, continue heat drying to moisture content and be lower than 1%;
In the 8th step, granulate: with granulated material of the 7th step, remove coarse grain with 20~16 mesh sieves sieve, coarse grain is put granulate in the pelletizing machine, reuse 20~16 eye mesh screens sieve behind the granulate.Collect 00~16 order granule;
In the 9th step, mix: second step was extracted the volatile oil that obtains be mixed in by spraying in the granule in the 8th step, it is first mixed spray earlier on one side, adds in 5~10% starch of its weight and 0.5~1.5% magnesium stearate postposition batch mixer to mix 5~15 minutes again;
The tenth step, filled capsules: with the 9th step obtain particles filled in No. 0~No. 2 capsules, capsule.
Four of the preparation method of a kind of Chinese patent medicine for the treatment of pulmonary carcinoma of the present invention, the preparation of powder the steps include:
The first step, batching: weighing by weight percentage, Radix Polygoni Multiflori Preparata 12%~19%; Radix Notoginseng 4%~9%; Bulbus Fritillariae Thunbergii 5%~8%; Fructus Trichosanthis 6%~9%; Semen Persicae (parched) 4%~9%; Eupolyphaga Seu Steleophaga 5%~9%; Radix Ginseng Rubra 6%~9%; Folium Isatidis 7%~15%; Radix Sophorae Tonkinensis 6%~9%; Poria 6%~9%; Semen Descurainiae (parched) 6%~9%; Pericarpium Citri Reticulatae 6%~9%;
Second step, the volatile oil of extraction Pericarpium Citri Reticulatae and Fructus Trichosanthis:, adopt vapor distillation method to extract volatile oil with Pericarpium Citri Reticulatae, the Fructus Trichosanthis that takes by weighing, be about to medical material and place the multipotency extraction pot, 8~10 times the water logging bubble that adds Pericarpium Citri Reticulatae and Fructus Trichosanthis weight is after 30 minutes, and straight-through Steam Heating proposes volatile oil; Collect volatile oil by " oil water separator ", standby; Its medical filtration is collected with container in addition, and is standby; Medicinal residues enter the 4th step operation decocting and carry;
The 3rd step, the active ingredient of extraction Radix Ginseng Rubra, Radix Notoginseng, Folium Isatidis: adopt " alcohol heat reflux method " to extract.The Radix Ginseng Rubra that is about to take by weighing, Radix Notoginseng, Folium Isatidis are put in the multipotency extraction pot, 60~80% ethanol that add 6~10 times of Radix Ginseng Rubra, Radix Notoginseng, Folium Isatidis weight, after the logical Steam Heating boiling of interlayer, clock, and control jacket steam amount 0.01~0.03Mpa is to little boiling, stop heating after 90 minutes, filter, collect filterable alcohol reflux liquid and use containers store standby in addition; Medicinal residues add 60~80% ethanol of 6~10 times of its weight as stated above again, and filtrate is extracted, filters, collected to same procedure, carry out so altogether 3 times, and after alcohol reflux liquid was collected and finished, medicinal residues entered down the operation decocting and carry;
The 4th step, decocting is carried: medicinal residues and the Radix Polygoni Multiflori Preparata that takes by weighing, Bulbus Fritillariae Thunbergii, Semen Descurainiae (parched), Semen Persicae (parched), Eupolyphaga Seu Steleophaga, Radix Sophorae Tonkinensis, the Poria of second step and three-procedure are merged, place the multipotency extraction pot, add the water of 10 times of weight, soaked 60 minutes, decoct 3 times, each 60 minutes, merge 3 times decocting liquid, filter, the medicinal liquid of the filtrate and the second step operation merges, for operation is concentrated down;
The 5th step, medicinal liquid concentrates: in the alcohol reflux liquid suction concentration tank that three-procedure is obtained, the decompression of unlatching vacuum valve, open steam valve heating recovery ethanol to complete substantially, " medicinal liquid " with the 4th step operation merges again, place the triple effect concentration tank altogether, open the steam valve heating, to relative density of medicine liquid be 1.05~1.15; When fluid temperature is 60 ℃, detect relative density with gravimeter;
In the 6th step, spray drying: the concentrated medicament that the 5th step operation is obtained places storage tank, opens vacuum and heating unit, and it is sprayed in the drying tower, collects dry thing, promptly gets extract powder;
The 7th step, mix: the second step operation is extracted the volatile oil spraying that obtains add in the 4-6 dry extract by spraying, earlier, add 5~15% starch and 0.5~1.5 Pulvis Talci again, and put to mix in the batch mixer and can obtain mixture in 10~15 minutes while the manual mixing of spraying.
In the 8th step, packing: with the packing of powder racking machine, loading amount is every bag 2~5 gram with the 7th mixture that obtain of step, powder.
Five of the preparation method of a kind of Chinese patent medicine for the treatment of pulmonary carcinoma of the present invention, the preparation of pill the steps include:
The first step, batching: weighing by weight percentage, Radix Polygoni Multiflori Preparata 12%~19%; Radix Notoginseng 4%~9%; Bulbus Fritillariae Thunbergii 5%~8%; Fructus Trichosanthis 6%~9%; Semen Persicae (parched) 4%~9%; Eupolyphaga Seu Steleophaga 5%~9%; Radix Ginseng Rubra 6%~9%; Folium Isatidis 7%~15%; Radix Sophorae Tonkinensis 6%~9%; Poria 6%~9%; Semen Descurainiae (parched) 6%~9%; Pericarpium Citri Reticulatae 6%~9%;
In second step, pulverize: will get Radix Notoginseng, Bulbus Fritillariae Thunbergii is ground into 100 order left and right sides fine powders with Universalpulverizer, and is standby;
The 3rd step, the volatile oil of extraction Pericarpium Citri Reticulatae and Fructus Trichosanthis:, adopt vapor distillation method to extract volatile oil with Pericarpium Citri Reticulatae, the Fructus Trichosanthis that takes by weighing, be about to medical material and place the multipotency extraction pot, 8~10 times the water logging bubble that adds Pericarpium Citri Reticulatae and Fructus Trichosanthis weight is after 30 minutes, and straight-through Steam Heating proposes volatile oil; Collect volatile oil by " oil water separator ", standby; Its medical filtration is collected with container in addition, and is standby; Medicinal residues enter the 5th step operation decocting and carry;
The 4th step, the active ingredient of extraction Radix Ginseng Rubra, Radix Notoginseng, Folium Isatidis: adopt " alcohol heat reflux method " to extract.The Radix Ginseng Rubra that is about to take by weighing, Radix Notoginseng, Folium Isatidis are put in the multipotency extraction pot, 60~80% ethanol that add 6~10 times of Radix Ginseng Rubra, Radix Notoginseng, Folium Isatidis weight, after the logical Steam Heating boiling of interlayer, clock, and control jacket steam amount 0.01~0.03Mpa is to little boiling, stop heating after 90 minutes, filter, collect filterable alcohol reflux liquid and use containers store standby in addition; Medicinal residues add 60~80% ethanol of 6~10 times of its weight as stated above again, and filtrate is extracted, filters, collected to same procedure, carry out so altogether 3 times, and after alcohol reflux liquid was collected and finished, medicinal residues entered the 5th step decocting and carry;
The 5th step, decocting is carried: medicinal residues and the Radix Polygoni Multiflori Preparata that takes by weighing, Bulbus Fritillariae Thunbergii, Semen Descurainiae (parched), Semen Persicae (parched), Eupolyphaga Seu Steleophaga, Radix Sophorae Tonkinensis, the Poria of second step and three-procedure are merged, place the multipotency extraction pot, add the water of 10 times of weight, soaked 60 minutes, decoct 3 times, each 60 minutes, merge 3 times decocting liquid, filter, the medicinal liquid of the filtrate and the second step operation merges, for operation is concentrated down;
The 6th step, medicinal liquid concentrates: in the alcohol reflux liquid suction concentration tank that three-procedure is obtained, the decompression of unlatching vacuum valve, open steam valve heating recovery ethanol to complete substantially, " medicinal liquid " with the 4th step operation merges again, place the triple effect concentration tank altogether, open the steam valve heating, to relative density of medicine liquid be 1.05~1.15; When fluid temperature is 60 ℃, detect relative density with gravimeter;
In the 7th step, spray drying: the concentrated medicament that the 5th step operation is obtained places storage tank, opens vacuum and heating unit, and it is sprayed in the drying tower, collects dry thing, promptly gets extract powder;
The 8th step, mix: second step was pulverized the Radix Notoginseng, the Bulbus Fritillariae Thunbergii powder and the 7th that obtain go on foot in the dry extract batch mixer behind the mix homogeneously, again extracted the volatile oil spraying that obtains the 3rd step and be mixed in this mixture, just mix, add 5~10% starch mixings of its weight again while spray earlier;
The 9th step, pill: the 8th hybrid medicine material that obtain of step is placed pellet processing machine, spraying add the raw material gross weight 30~50%, concentration be 10~30% ethanol liquid as binding agent, general one-tenth pill, control weight is at 0.1~0.15g/ grain;
The tenth step, packing: above-mentioned qualified pill is packed in the medicine bottle with racking machine, promptly make pill.
Six of the preparation method of a kind of Chinese patent medicine for the treatment of pulmonary carcinoma of the present invention, the preparation of tablet the steps include:
The first step, batching: weighing by weight percentage, Radix Polygoni Multiflori Preparata 12%~19%; Radix Notoginseng 4%~9%; Bulbus Fritillariae Thunbergii 5%~8%; Fructus Trichosanthis 6%~9%; Semen Persicae (parched) 4%~9%; Eupolyphaga Seu Steleophaga 5%~9%; Radix Ginseng Rubra 6%~9%; Folium Isatidis 7%~15%; Radix Sophorae Tonkinensis 6%~9%; Poria 6%~9%; Semen Descurainiae (parched) 6%~9%; Pericarpium Citri Reticulatae 6%~9%;
In second step, pulverize: the Radix Notoginseng, the Bulbus Fritillariae Thunbergii that take by weighing are ground into 100 order left and right sides fine powders with Universalpulverizer, standby;
The 3rd step, the volatile oil of extraction Pericarpium Citri Reticulatae and Fructus Trichosanthis:, adopt vapor distillation method to extract volatile oil with Pericarpium Citri Reticulatae, the Fructus Trichosanthis that takes by weighing, be about to medical material and place the multipotency extraction pot, 8~10 times the water logging bubble that adds Pericarpium Citri Reticulatae and Fructus Trichosanthis weight is after 30 minutes, and straight-through Steam Heating proposes volatile oil; Collect volatile oil by " oil water separator ", standby; Its medical filtration is collected with container in addition, and is standby; Medicinal residues enter the 5th step operation decocting and carry;
The 4th step, the active ingredient of extraction Radix Ginseng Rubra, Radix Notoginseng, Folium Isatidis: adopt " alcohol heat reflux method " to extract.The Radix Ginseng Rubra that is about to take by weighing, Radix Notoginseng, Folium Isatidis are put in the multipotency extraction pot, 60~80% ethanol that add 6~10 times of Radix Ginseng Rubra, Radix Notoginseng, Folium Isatidis weight, after the logical Steam Heating boiling of interlayer, clock, and control jacket steam amount 0.02~0.04Mpa is to little boiling, stop heating after 90 minutes, filter, collect filterable alcohol reflux liquid and use containers store standby in addition; Medicinal residues add 60~80% ethanol of 6~10 times of its weight as stated above again, and filtrate is extracted, filters, collected to same procedure, carry out so altogether 3 times, and after alcohol reflux liquid was collected and finished, medicinal residues entered down the operation decocting and carry;
The 5th step, decocting is carried: medicinal residues and the Radix Polygoni Multiflori Preparata that takes by weighing, Bulbus Fritillariae Thunbergii, Semen Descurainiae (parched), Semen Persicae (parched), Eupolyphaga Seu Steleophaga, Radix Sophorae Tonkinensis, the Poria of second step and three-procedure are merged, place the multipotency extraction pot, add the water of 10 times of weight, soaked 60 minutes, decoct 3 times, each 60 minutes, merge 3 times decocting liquid, filter, the medicinal liquid of the filtrate and the second step operation merges, for operation is concentrated down;
The 6th step, medicinal liquid concentrates: in the alcohol reflux liquid suction concentration tank that three-procedure is obtained, the decompression of unlatching vacuum valve, open steam valve heating recovery ethanol to complete substantially, " medicinal liquid " with the 4th step operation merges again, place the triple effect concentration tank altogether, open the steam valve heating, to relative density of medicine liquid be 1.05~1.15; When fluid temperature is 60 ℃, detect relative density with gravimeter;
The 7th step, spray drying: the concentrated medicament in the 6th step is placed storage tank, open vacuum and heating unit, with 1.0~1.5kg/ minute speed it is sprayed in the drying tower again, collect dry thing, promptly get dry extract;
The 8th step, granulate: after the dry extract that Radix Notoginseng, Bulbus Fritillariae Thunbergii powder and the 7th step that second step was obtained obtains places the one-step-granulating method mix homogeneously, 5~10% starch that add gross weight again, the concentration that spraying adds material gross weight 50~60% is that 15%~40% ethanol liquid is granulated drying as binding agent;
In the 9th step, granulate: with granulated material of the 8th step, sift out coarse grain with 20~12 eye mesh screens, coarse grain is put granulate in the pelletizing machine, reuse 20~12 eye mesh screens sieve behind the granulate;
The tenth step, mix: the 3rd step was extracted the volatile oil spraying that obtains be mixed in the granule that the 9th step obtained, just mix while spraying earlier, the medicinal carboxymethylstach sodium and 0.5~1.5% Pulvis Talci that add its weight 0.5%~3% again, put and mix 5~15 minutes in the batch mixer, promptly can be made into tablet;
The 11 step, tabletting: with the tenth mixture that make of step, be pressed into tablet, and control strip focuses on 0.4 ± 0.02g by tablet machine, tablet diameter of phi=6~8mm.
Chinese patent medicine one granule of the treatment pulmonary carcinoma by said method system, through zoopery, the result show have supplementing QI and nourishing YIN, the function of blood circulation promoting and blood stasis dispelling, detoxicating and resolving stagnation of pathogens, reinforcing kidney and strengthening resistance.The correlation test result is as follows:
One, the test of pesticide effectiveness is chosen 52 of healthy Kunming mouses, and body weight 18-22g is divided into 5 groups at random, except that 12 of matched groups, and all the other per 10, male and female half and half, do respectively:
First group is the blank group: normal saline (0.5ml/20g), once a day, continuous 10 days; Second and third, four groups for the large, medium and small three kinds of test dose groups of product of the present invention: (liquor strength is respectively 0.27,0.81,1.62g crude drug/ml to gavage 2.7g, 8.1g, 16.2g/kg crude drug/kg, the administration volume is the 0.5ml/20g body weight), once a day, continuous 10 days; The 5th group of positive matched group: injection 5-Fu25mg/kg, once a day, continuous 10 days.Drug withdrawal next day, write down the dead mouse situation day by day.After treating all animals death, calculate each treated animal The average survival time natural law, calculate increase in life span as follows.
The result shows: (1) Chinese patent medicine of the present invention has the obvious suppression effect to the growth of animal transplanting tumor (lewis pulmonary carcinoma, sarcoma S180 solid type, S180A ascitic type, liver HepA ascitic type), and tumour inhibiting rate is more than 30~50%; Increase in life span is more than 60%; (2) Chinese patent medicine 0.5~8mg/ml of the present invention can make human cytomegalovirus pulmonary carcinoma (A2), adenocarcinoma of lung (SPC-A1), hepatocarcinoma cancerous cell such as (SMMC-7721) that tangible degeneration, necrosis take place, cancerous cell karyokinesis index, cell survival rate obviously reduce, and tangible dosage correlation and temporal correlation are arranged; (3) Chinese patent medicine of the present invention all has the obvious suppression effect to the biosynthesis of human cytomegalovirus pulmonary carcinoma (A2), adenocarcinoma of lung (SPC-A1), hepatocarcinoma cell DNAs such as (SMMC-7721); (4) Chinese patent medicine of the present invention has stronger kill capability (making colony form obvious minimizing) to people's cancer (A2, SPC-A1, SMMC-7721) stem cell (it and tumor infinite multiplication power, recurrence and transfer have substantial connection, are the most significant target cells of chemotherapy); (5) Chinese patent medicine of the present invention can obviously strengthen the mouse cell immunologic function; (6) effect of Chinese patent medicine unrestraint mouse hematopoietic stem cell of the present invention.In sum, with external tangible cancer suppressing action is arranged all in this medicine body, but do not suppress the myeloid element function, also have the effect that strengthens cellular immune function simultaneously.
Two, use the clinical research confirmation of Chinese patent drugs for treatment 31 routine pulmonary carcinoma of the present invention, this medicine has the obvious treatment effect to pulmonary carcinoma, and especially cell and the humoral immunization to patients with lung cancer all has tangible regulating action.
Three, a kind of pulmonary carcinoma for the treatment of of the present invention is main Chinese patent medicine, taste is comfortable, can significantly improve the pulmonary carcinoma symptom after taking, or effectively treat lung bronchogenic carcinoma and cure mainly syndrome, symptoms including cough tachypnea, spiritlessness and weakness, the yellow thick difficulty of expectorant are coughed up or sputum mixed with blood, fullness and distention in the chest and hypochondrium or twinge, dry mouth and constipation, spontaneous perspiration or night sweat etc.It is little, in light weight, easy to carry to have volume, the advantage of sanitation and hygiene, long shelf-life.
The specific embodiment
Must meet office of State Food and Drug Administration standard or Chinese Pharmacopoeia standard code to the raw material that uses.
Case study on implementation 1: prepare a kind of Chinese patent medicine for the treatment of pulmonary carcinoma---granule.
(1) its raw material and percentage by weight are: Radix Polygoni Multiflori Preparata 15%, Radix Notoginseng 6%, Bulbus Fritillariae Thunbergii 6%, Fructus Trichosanthis 7%, Semen Persicae (parched) 6%, Eupolyphaga Seu Steleophaga 7%, Radix Ginseng Rubra 8%, Folium Isatidis 13%, Radix Sophorae Tonkinensis 8%, Poria 8%, Semen Descurainiae (parched) 8%, Pericarpium Citri Reticulatae 8%; Preparation process is:
(2) batching takes by weighing Radix Polygoni Multiflori Preparata 15kg, Radix Notoginseng 6kg, Bulbus Fritillariae Thunbergii 6kg, Fructus Trichosanthis 7kg, Semen Persicae (parched) (stir-fry) 6kg, Eupolyphaga Seu Steleophaga 7kg by the percentage by weight of above-mentioned prescription; Radix Ginseng Rubra 8kg, Folium Isatidis 13kg, Radix Sophorae Tonkinensis 8kg, Poria 8kg, Semen Descurainiae (parched) (stir-fry) 8kg, Pericarpium Citri Reticulatae 8kg;
(3) extract volatile oil,, adopt steam distillation to propose volatile oil, collect volatile oil by oil water separator with Pericarpium Citri Reticulatae, the Fructus Trichosanthis that takes by weighing, standby; Aqueous solution device collection in addition concentrates for follow-up merging, and medicinal residues enter down the operation decocting and carry;
(4) alcohol heat reflux extracts, and Radix Ginseng Rubra, Radix Notoginseng, the Folium Isatidis that takes by weighing added 7 times of amounts of 70% ethanol, reflux, extract, 3 times, and each 90 minutes, alcohol reflux liquid device collection in addition reclaimed ethanol with concentrated for the back operation, and medicinal residues enter down the operation decocting and carry;
(5) decocting is carried, with (3), (4) medicinal residues and all the other Radix Polygoni Multiflori Preparatas, Bulbus Fritillariae Thunbergii, Semen Descurainiae (parched), Semen Persicae (parched), Eupolyphaga Seu Steleophaga, Radix Sophorae Tonkinensis, Poria seven flavors, add 10 times of water gagings, soaked 60 minutes, and decocted each 60 minutes 3 times, collecting decoction, filter, filtrate and above-mentioned aqueous solution and concentrated solution merge, and concentrate for the back operation;
(6) concentrate, in above-mentioned alcohol reflux liquid suction concentration tank, open the vacuum valve decompression, open steam valve heating recovery ethanol to complete substantially; Medicinal liquid and said extracted liquid merge, and put the triple effect concentration tank altogether, open the steam valve heating, get final product to relative density of medicine liquid 1.10 (60 ℃ time detect);
(7) spray drying places storage tank with above-mentioned concentrated medicament, opens vacuum and heating unit, with suitable speed it is sprayed in the drying tower again, collects dry thing, promptly gets extract powder;
(8) granulate, get an amount of dextrin of above-mentioned extract powder, place the one-step-granulating method mix homogeneously after, spraying adds an amount of 20% ethanol liquid granulates as binding agent, dry back;
(9) granulate with granulated material, removes fine powder or granule with 80 mesh sieves sieves, and sieve with 10 mesh sieves and go coarse grain, coarse grain to put that granulate to granule is 80~10 orders in the pelletizing machine;
(10) mix, the volatile oil spraying that extraction is obtained adds in the qualified dried granule of above-mentioned granularity by spraying, and it is manual first mixed spray earlier on one side, puts that mixing got final product in 12 minutes in the batch mixer again;
(11) qualified granule is got in packing, with the packing of granule racking machine, loading amount be every bag 5 gram granule.
The percentage by weight of case study on implementation 1 is adjusted into:
Radix Polygoni Multiflori Preparata 18%, Radix Notoginseng 9%, Bulbus Fritillariae Thunbergii 8%, Fructus Trichosanthis 9%, Semen Persicae (parched) 6%, Eupolyphaga Seu Steleophaga 7%, Radix Ginseng Rubra 7.5%, Folium Isatidis 11.5%, Radix Sophorae Tonkinensis 6%, Poria 6%, Semen Descurainiae (parched) 6%, Pericarpium Citri Reticulatae 6%,
Or Radix Polygoni Multiflori Preparata 12%, Radix Notoginseng 4%, Bulbus Fritillariae Thunbergii 5%, Fructus Trichosanthis 9%, Semen Persicae (parched) 9%, Eupolyphaga Seu Steleophaga 9%, Radix Ginseng Rubra 9%, Folium Isatidis 15%, Radix Sophorae Tonkinensis 7%, Poria 7%, Semen Descurainiae (parched) 7%, Pericarpium Citri Reticulatae 7%,
Or Radix Polygoni Multiflori Preparata 16%, Radix Notoginseng 6%, Bulbus Fritillariae Thunbergii 6.5%, Fructus Trichosanthis 7.5%, Semen Persicae (parched) 6.5%, Eupolyphaga Seu Steleophaga 7%, Radix Ginseng Rubra 7.5%, Folium Isatidis 7%, Radix Sophorae Tonkinensis 9%, Poria 9%, Semen Descurainiae (parched) (stir-fry) 9%, Pericarpium Citri Reticulatae 9%,
Or Radix Polygoni Multiflori Preparata 19%, Radix Notoginseng 9%, Bulbus Fritillariae Thunbergii 8%, Fructus Trichosanthis 6%, Semen Persicae (parched) 4%, Eupolyphaga Seu Steleophaga 5%, Radix Ginseng Rubra 6%, Folium Isatidis 10%, Radix Sophorae Tonkinensis 8%, Poria 8%, Semen Descurainiae (parched) 8%, Pericarpium Citri Reticulatae 8%;
Alcohol heat reflux extracts, and Radix Ginseng Rubra, Radix Notoginseng, the Folium Isatidis that takes by weighing added 60% or 70% or 80% ethanol 6 or 7 or 8 or 10 times of amounts, reflux, extract, 3 times, and each 90 minutes ...;
Concentrate ... relative density of medicine liquid 1.05 or 1.15 (60 ℃) gets final product;
Mix ... put again to mix in the batch mixer and got final product in 10 or 15 minutes;
It is constant to prepare other steps, can be made into the Chinese patent medicine---granule of the treatment pulmonary carcinoma of four kinds of different components ratios.
Embodiment 2: prepare a kind of Chinese patent medicine for the treatment of pulmonary carcinoma---oral liquid.
(1) its raw material and percentage by weight thereof are: Radix Polygoni Multiflori Preparata 19%, Radix Notoginseng 5%, Bulbus Fritillariae Thunbergii 6%, Fructus Trichosanthis 6%, Semen Persicae (parched) 6%, Eupolyphaga Seu Steleophaga 9%, Radix Ginseng Rubra 7%, Folium Isatidis 14%, Radix Sophorae Tonkinensis 7%, Poria 7%, Semen Descurainiae (parched) 7%, Pericarpium Citri Reticulatae 7%; Preparation process is:
(2) batching takes by weighing Radix Polygoni Multiflori Preparata 19kg, Radix Notoginseng 5kg, Bulbus Fritillariae Thunbergii 6kg, Fructus Trichosanthis 6kg, Semen Persicae (parched) 6kg, Eupolyphaga Seu Steleophaga 9kg by the percentage by weight of above-mentioned prescription; Radix Ginseng Rubra 7kg, Folium Isatidis 14kg, Radix Sophorae Tonkinensis 7kg, Poria 7kg, Semen Descurainiae (parched) 7kg, Pericarpium Citri Reticulatae 7kg;
(3) extract volatile oil,, adopt steam distillation to propose volatile oil, collect volatile oil by oil water separator with Pericarpium Citri Reticulatae, the Fructus Trichosanthis that takes by weighing, standby; Aqueous solution device collection in addition concentrates for follow-up merging, and medicinal residues enter down the operation decocting and carry;
(4) alcohol heat reflux extracts, and Radix Ginseng Rubra, Radix Notoginseng, the Folium Isatidis that takes by weighing added 7 times of amounts of 70% ethanol, reflux, extract, 3 times, and each 90 minutes, alcohol reflux liquid device collection in addition reclaimed ethanol with concentrated for the back operation, and medicinal residues enter down the operation decocting and carry;
(5) decocting is carried, above-mentioned medicinal residues and all the other Radix Polygoni Multiflori Preparatas, Bulbus Fritillariae Thunbergii, Semen Descurainiae (parched), Semen Persicae (parched), Eupolyphaga Seu Steleophaga, Radix Sophorae Tonkinensis, Poria seven flavors, add 10 times of water gagings, soaked 60 minutes, and decocted each 60 minutes 3 times, collecting decoction, filter, filtrate and above-mentioned aqueous solution and concentrated solution merge, and concentrate for the back operation;
(5) concentrate, in above-mentioned alcohol reflux liquid suction concentration tank, open the vacuum valve decompression, open steam valve heating recovery ethanol to complete substantially; Medicinal liquid and said extracted liquid merge, and put the triple effect concentration tank altogether, open the steam valve heating, get final product to relative density of medicine liquid 1.10 (60 ℃);
(6) place filtration, above-mentioned concentrated medicament placement after 24 hours, is filtered;
(7) dosing: in the concentrated medicament after the above-mentioned volatile oil adding filtration that obtains, the Tween 80 that adds raw material gross weight 3% again is that the protein sugar of solubilizing agent and raw material gross weight 1.0% is a flavoring agent, stirs, and promptly makes oral liquid.
The percentage by weight of case study on implementation 2 is adjusted into:
Radix Polygoni Multiflori Preparata 18%, Radix Notoginseng 9%, Bulbus Fritillariae Thunbergii 8%, Fructus Trichosanthis 9%, Semen Persicae (parched) 6%, Eupolyphaga Seu Steleophaga 7%, Radix Ginseng Rubra 7.5%, Folium Isatidis 11.5%, Radix Sophorae Tonkinensis 6%, Poria 6%, Semen Descurainiae (parched) 6%, Pericarpium Citri Reticulatae 6%,
Or Radix Polygoni Multiflori Preparata 12%, Radix Notoginseng 4%, Bulbus Fritillariae Thunbergii 5%, Fructus Trichosanthis 9%, Semen Persicae (parched) 9%, Eupolyphaga Seu Steleophaga 9%, Radix Ginseng Rubra 9%, Folium Isatidis 15%, Radix Sophorae Tonkinensis 7%, Poria 7%, Semen Descurainiae (parched) 7%, Pericarpium Citri Reticulatae 7%,
Or Radix Polygoni Multiflori Preparata 16%, Radix Notoginseng 6%, Bulbus Fritillariae Thunbergii 6.5%, Fructus Trichosanthis 7.5%, Semen Persicae (parched) 6.5%, Eupolyphaga Seu Steleophaga 7%, Radix Ginseng Rubra 7.5%, Folium Isatidis 7%, Radix Sophorae Tonkinensis 9%, Poria 9%, Semen Descurainiae (parched) 9%, Pericarpium Citri Reticulatae 9%,
Or Radix Polygoni Multiflori Preparata 19%, Radix Notoginseng 9%, Bulbus Fritillariae Thunbergii 8%, Fructus Trichosanthis 6%, Semen Persicae (parched) 4%, Eupolyphaga Seu Steleophaga 5%, Radix Ginseng Rubra 6%, Folium Isatidis 10%, Radix Sophorae Tonkinensis 8%, Poria 8%, Semen Descurainiae (parched) 8%, Pericarpium Citri Reticulatae 8%;
Alcohol heat reflux extracts, and Radix Ginseng Rubra, Radix Notoginseng, the Folium Isatidis that takes by weighing added 60% or 70% or 80% ethanol 6 or 7 or 8 or 10 times of amounts, reflux, extract, 3 times, and each 90 minutes ...;
Concentrate ... relative density of medicine liquid 1.05 or 1.15 (60 ℃) gets final product;
Dosing: ... add the tween of raw material gross weight 1% or 2% or 4%
80For the protein sugar of solubilizing agent and raw material gross weight 0.5 or 1.0% is a flavoring agent, stir, promptly make oral liquid;
It is constant to prepare other steps, can be made into the Chinese patent medicine---oral liquid of the treatment pulmonary carcinoma of four kinds of different components ratios.
Embodiment 3: prepare a kind of Chinese patent medicine for the treatment of pulmonary carcinoma---capsule.
(1) its raw material and percentage by weight are: Radix Polygoni Multiflori Preparata 12%, Radix Notoginseng 4%, Bulbus Fritillariae Thunbergii 5%, Fructus Trichosanthis 8%, Semen Persicae (parched) 9%, Eupolyphaga Seu Steleophaga 9%, Radix Ginseng Rubra 9%, Folium Isatidis 13%, Radix Sophorae Tonkinensis 8%, Poria 8%, Semen Descurainiae (parched) 8%, Pericarpium Citri Reticulatae 8%; Preparation process is:
(2) batching takes by weighing Radix Polygoni Multiflori Preparata 12kg, Radix Notoginseng 4kg, Bulbus Fritillariae Thunbergii 5kg, Fructus Trichosanthis 8kg, Semen Persicae (parched) (stir-fry) 9kg, Eupolyphaga Seu Steleophaga 9kg by the percentage by weight of above-mentioned prescription; Radix Ginseng Rubra 9kg, Folium Isatidis 13kg, Radix Sophorae Tonkinensis 8kg, Poria 8kg, Semen Descurainiae (parched) (stir-fry) 8kg, Pericarpium Citri Reticulatae 8kg;
(3) extract volatile oil,, adopt steam distillation to propose volatile oil, collect volatile oil by oil water separator with Pericarpium Citri Reticulatae, the Fructus Trichosanthis that takes by weighing, standby; Aqueous solution device collection in addition concentrates for follow-up merging, and medicinal residues enter down the operation decocting and carry;
(4) alcohol heat reflux extracts, and Radix Ginseng Rubra, Radix Notoginseng, the Folium Isatidis that takes by weighing added 7 times of amounts of 70% ethanol, reflux, extract, 3 times, and each 90 minutes, alcohol reflux liquid device collection in addition reclaimed ethanol with concentrated for the back operation, and medicinal residues enter down the operation decocting and carry;
(5) decocting is carried, above-mentioned medicinal residues and all the other Radix Polygoni Multiflori Preparatas, Bulbus Fritillariae Thunbergii, Semen Descurainiae (parched), Semen Persicae (parched), Eupolyphaga Seu Steleophaga, Radix Sophorae Tonkinensis, Poria seven flavors, add 10 times of water gagings, soaked 60 minutes, and decocted each 60 minutes 3 times, collecting decoction, filter, filtrate and above-mentioned aqueous solution and concentrated solution merge, and concentrate for the back operation;
(6) concentrate, in above-mentioned alcohol reflux liquid suction concentration tank, open the vacuum valve decompression, open steam valve heating recovery ethanol to complete substantially; Medicinal liquid and said extracted liquid merge, and put the triple effect concentration tank altogether, open the steam valve heating, get final product to relative density of medicine liquid 1.10 (60 ℃);
(7) spray drying places storage tank with above-mentioned concentrated medicament, opens vacuum and heating unit, with suitable speed it is sprayed in the drying tower again, collects dry thing, promptly gets extract powder;
(8) granulate, get the dextrin of above-mentioned extract powder and 1/2~2/3 " medical material weight ", place the one-step-granulating method mix homogeneously after, slowly spraying 1/3~1/2 20%~30% ethanol liquid that adds extract powder and dextrin gross weight is made binding agent, dry back;
(9) granulate with granulated material, sifts out coarse grain with 20 eye mesh screens, coarse grain is put granulate in the pelletizing machine, reuse 20 eye mesh screens behind the granulate;
(10) mix: the volatile oil spraying that extraction is obtained is mixed in the above-mentioned dried granule, and it is manual just mixed spray earlier on one side, adds that mixing got final product in 10 minutes in 6% dextrin of its weight and the 1.2% magnesium stearate postposition batch mixer again;
(11) filled capsules: particles filled in No. 0 capsule with above-mentioned mixing, capsule.
The percentage by weight of case study on implementation 3 is adjusted into:
Radix Polygoni Multiflori Preparata 18%, Radix Notoginseng 9%, Bulbus Fritillariae Thunbergii 8%, Fructus Trichosanthis 9%, Semen Persicae (parched) 6%, Eupolyphaga Seu Steleophaga 7%, Radix Ginseng Rubra 7.5%, Folium Isatidis 11.5%, Radix Sophorae Tonkinensis 6%, Poria 6%, Semen Descurainiae (parched) 6%, Pericarpium Citri Reticulatae 6%,
Or Radix Polygoni Multiflori Preparata 12%, Radix Notoginseng 4%, Bulbus Fritillariae Thunbergii 5%, Fructus Trichosanthis 9%, Semen Persicae (parched) 9%, Eupolyphaga Seu Steleophaga 9%, Radix Ginseng Rubra 9%, Folium Isatidis 15%, Radix Sophorae Tonkinensis 7%, Poria 7%, Semen Descurainiae (parched) 7%, Pericarpium Citri Reticulatae 7%,
Or Radix Polygoni Multiflori Preparata 16%, Radix Notoginseng 6%, Bulbus Fritillariae Thunbergii 6.5%, Fructus Trichosanthis 7.5%, Semen Persicae (parched) 6.5%, Eupolyphaga Seu Steleophaga 7%, Radix Ginseng Rubra 7.5%, Folium Isatidis 7%, Radix Sophorae Tonkinensis 9%, Poria 9%, Semen Descurainiae (parched) 9%, Pericarpium Citri Reticulatae 9%,
Or Radix Polygoni Multiflori Preparata 19%, Radix Notoginseng 9%, Bulbus Fritillariae Thunbergii 8%, Fructus Trichosanthis 6%, Semen Persicae (parched) 4%, Eupolyphaga Seu Steleophaga 5%, Radix Ginseng Rubra 6%, Folium Isatidis 10%, Radix Sophorae Tonkinensis 8%, Poria 8%, Semen Descurainiae (parched) 8%, Pericarpium Citri Reticulatae 8%;
Alcohol heat reflux extracts, and Radix Ginseng Rubra, Radix Notoginseng, the Folium Isatidis that takes by weighing added 60% or 70% or 80% ethanol 6 or 7 or 8 or 10 times of amounts ...;
Concentrate ... relative density of medicine liquid 1.05 or 1.15 (60 ℃) gets final product;
Granulate ... 20% or 30% ethanol liquid is that binding agent is granulated, dry back;
Granulate ... sift out coarse grain with 18 or 16 eye mesh screens, coarse grain is put granulate in the pelletizing machine, reuse 18 or 16 eye mesh screens behind the granulate;
Mix: will ... add again to mix in 5% or 7%, 10% starch of its weight and the rearmounted batch mixer of 0.5% or 1.5% magnesium stearate and got final product in 5 minutes or 15 minutes;
Filled capsules: particles filled in No. 1 or No. 2 capsules with above-mentioned mixing, capsule.
It is constant to prepare other steps, can be made into the Chinese patent medicine---capsule of the treatment pulmonary carcinoma of four kinds of different components ratios.
Embodiment 4: prepare a kind of Chinese patent medicine for the treatment of pulmonary carcinoma---powder.
(1) its raw material and W/W are: Radix Polygoni Multiflori Preparata 14%, Radix Notoginseng 8%, Bulbus Fritillariae Thunbergii 7%, Fructus Trichosanthis 8%, Semen Persicae (parched) 8%, Eupolyphaga Seu Steleophaga 7%, Radix Ginseng Rubra 8%, Folium Isatidis 13%, Radix Sophorae Tonkinensis 8%, Poria 7%, Semen Descurainiae (parched) 6%, Pericarpium Citri Reticulatae 6%; Preparation process is:
(2) batching takes by weighing Radix Polygoni Multiflori Preparata 14kg, Radix Notoginseng 8kg, Bulbus Fritillariae Thunbergii 7kg, Fructus Trichosanthis 8kg, Semen Persicae (parched) 8kg, Eupolyphaga Seu Steleophaga 7kg by the percentage by weight of above-mentioned prescription; Radix Ginseng Rubra 7kg, Folium Isatidis 14kg, Radix Sophorae Tonkinensis 8kg, Poria 7kg, Semen Descurainiae (parched) 6kg, Pericarpium Citri Reticulatae 6kg;
(3) extract volatile oil,, adopt steam distillation to propose volatile oil, collect volatile oil by oil water separator with Pericarpium Citri Reticulatae, the Fructus Trichosanthis that takes by weighing, standby; Aqueous solution device collection in addition concentrates for follow-up merging, and medicinal residues enter down the operation decocting and carry;
(4) alcohol heat reflux extracts, and Radix Ginseng Rubra, Radix Notoginseng, the Folium Isatidis that takes by weighing added 7 times of amounts of 70% ethanol, reflux, extract, 3 times, and each 90 minutes, alcohol reflux liquid device collection in addition reclaimed ethanol with concentrated for the back operation, and medicinal residues enter down the operation decocting and carry;
(5) decocting is carried, above-mentioned medicinal residues and all the other Radix Polygoni Multiflori Preparatas, Bulbus Fritillariae Thunbergii, Semen Descurainiae (parched), Semen Persicae (parched), Eupolyphaga Seu Steleophaga, Radix Sophorae Tonkinensis, Poria seven flavors, add 10 times of water gagings, soaked 60 minutes, and decocted each 60 minutes 3 times, collecting decoction, filter, filtrate and above-mentioned aqueous solution and concentrated solution merge, and concentrate for the back operation;
(6) concentrate, in above-mentioned alcohol reflux liquid suction concentration tank, open the vacuum valve decompression, open steam valve heating recovery ethanol to complete substantially; Medicinal liquid and said extracted liquid merge, and put the triple effect concentration tank altogether, open the steam valve heating, get final product to relative density of medicine liquid 1.10 (60 ℃);
(7) spray drying places storage tank with above-mentioned concentrated medicament, opens vacuum and heating unit, with suitable speed it is sprayed in the drying tower again, collects dry thing, promptly gets extract powder;
(8) mix: the volatile oil spraying that extraction is obtained adds in the above-mentioned dry extract by spraying, and the manual mixing of spraying earlier on one side adds 10% starch and 1.0 Pulvis Talci again, and puts that mixing got final product in 10 minutes in the batch mixer;
(9) packing, with said mixture powder racking machine packing, loading amount is that every bag 2 gram gets final product.
The percentage by weight of case study on implementation 4 is adjusted into:
Radix Polygoni Multiflori Preparata 18%, Radix Notoginseng 9%, Bulbus Fritillariae Thunbergii 8%, Fructus Trichosanthis 9%, Semen Persicae (parched) 6%, Eupolyphaga Seu Steleophaga 7%, Radix Ginseng Rubra 7.5%, Folium Isatidis 11.5%, Radix Sophorae Tonkinensis 6%, Poria 6%, Semen Descurainiae (parched) 6%, Pericarpium Citri Reticulatae 6%,
Or Radix Polygoni Multiflori Preparata 12%, Radix Notoginseng 4%, Bulbus Fritillariae Thunbergii 5%, Fructus Trichosanthis 9%, Semen Persicae (parched) 9%, Eupolyphaga Seu Steleophaga 9%, Radix Ginseng Rubra 9%, Folium Isatidis 15%, Radix Sophorae Tonkinensis 7%, Poria 7%, Semen Descurainiae (parched) 7%, Pericarpium Citri Reticulatae 7%,
Or Radix Polygoni Multiflori Preparata 16%, Radix Notoginseng 6%, Bulbus Fritillariae Thunbergii 6.5%, Fructus Trichosanthis 7.5%, Semen Persicae (parched) 6.5%, Eupolyphaga Seu Steleophaga 7%, Radix Ginseng Rubra 7.5%, Folium Isatidis 7%, Radix Sophorae Tonkinensis 9%, Poria 9%, Semen Descurainiae (parched) 9%, Pericarpium Citri Reticulatae 9%,
Or Radix Polygoni Multiflori Preparata 19%, Radix Notoginseng 9%, Bulbus Fritillariae Thunbergii 8%, Fructus Trichosanthis 6%, Semen Persicae (parched) 4%, Eupolyphaga Seu Steleophaga 5%, Radix Ginseng Rubra 6%, Folium Isatidis 10%, Radix Sophorae Tonkinensis 8%, Poria 8%, Semen Descurainiae (parched) 8%, Pericarpium Citri Reticulatae 8%;
Alcohol heat reflux extracts, Radix Ginseng Rubra, Radix Notoginseng, the Folium Isatidis that takes by weighing added 60% or 70% or 80% ethanol 6 or 7 or 8 or 10 times of amounts, reflux, extract, 3 times, each 90 minutes, alcohol reflux liquid device collection in addition reclaims ethanol with concentrated for the back operation, and medicinal residues enter down the operation decocting and carry;
Concentrate ... relative density of medicine liquid 1.05 or 1.15 (60 ℃) gets final product;
Mix: ... add 5~15% starch and 0.5~1.5 Pulvis Talci, and put to mix in the batch mixer and got final product in 10~15 minutes;
Packing ... loading amount be every bag 3 the gram or 4 the gram or 5 the gram get final product.
It is constant to prepare other steps, can be made into the Chinese patent medicine---powder of the treatment pulmonary carcinoma of four kinds of different components ratios.
Embodiment 5: prepare a kind of Chinese patent medicine for the treatment of pulmonary carcinoma---pill.
(1) its raw material and W/W are: Radix Polygoni Multiflori Preparata 12%, Radix Notoginseng 9%, Bulbus Fritillariae Thunbergii 5%, Fructus Trichosanthis 9%, Semen Persicae (parched) 4%, Eupolyphaga Seu Steleophaga 9%, Radix Ginseng Rubra 9%, Folium Isatidis 14%, Radix Sophorae Tonkinensis 6%, Poria 9%, Semen Descurainiae (parched) 6%, Pericarpium Citri Reticulatae 8%; Preparation process is:
(2) batching takes by weighing Radix Polygoni Multiflori Preparata 12kg, Radix Notoginseng 9kg, Bulbus Fritillariae Thunbergii 5kg, Fructus Trichosanthis 9kg, Semen Persicae (parched) 4kg, Eupolyphaga Seu Steleophaga 9kg by the percentage by weight of above-mentioned prescription; Radix Ginseng Rubra 9kg, Folium Isatidis 14kg, Radix Sophorae Tonkinensis 6kg, Poria 9kg, Semen Descurainiae (parched) 6kg, Pericarpium Citri Reticulatae 8kg;
(3) pulverize, will get Radix Notoginseng, Bulbus Fritillariae Thunbergii is ground into 100 order left and right sides fine powders with Universalpulverizer, and is standby;
(4) extract volatile oil: with Pericarpium Citri Reticulatae, the Fructus Trichosanthis that takes by weighing, adopt steam distillation to propose volatile oil, collect volatile oil by oil water separator, standby; Aqueous solution device collection in addition concentrates for follow-up merging, and medicinal residues enter down the operation decocting and carry;
(5) alcohol heat reflux extracts: Radix Ginseng Rubra, the Folium Isatidis that takes by weighing added 6~10 times of amounts of 60~80% ethanol, and reflux, extract, 3 times, each 90 minutes, alcohol reflux liquid device collection in addition reclaimed ethanol with concentrated for the back operation, and medicinal residues enter down the operation decocting and carry;
(6) decocting is carried: above-mentioned medicinal residues and all the other Radix Polygoni Multiflori Preparatas, Semen Descurainiae (parched), Semen Persicae (parched), Eupolyphaga Seu Steleophaga, Radix Sophorae Tonkinensis, Poria seven flavors, add 10 times of water gagings, and soaked 60 minutes, decoct 3 times, each 60 minutes, collecting decoction, filter, filtrate and above-mentioned aqueous solution and concentrated solution merge, and concentrate for the back operation;
(7) concentrate: in above-mentioned alcohol reflux liquid suction concentration tank, open the vacuum valve decompression, open steam valve heating recovery ethanol to complete substantially; Medicinal liquid and said extracted liquid merge, and put the triple effect concentration tank altogether, open the steam valve heating, get final product to relative density of medicine liquid 1.10 (60 ℃);
(8) spray drying: above-mentioned concentrated medicament is placed storage tank, open vacuum and heating unit, with suitable speed it is sprayed in the drying tower again, collect dry thing, promptly get dry extract;
(9) mix: behind the mix homogeneously, the volatile oil spraying that again extraction is obtained is mixed in this mixture in Radix Notoginseng, Bulbus Fritillariae Thunbergii powder and the above-mentioned dry extract batch mixer that pulverizing is obtained, and it is first by hand mixed spray earlier on one side, adds 8% starch mixing of its weight again;
(10) pill places pellet processing machine with above-mentioned hybrid medicine material, spraying add the raw material gross weight 35%, concentration be 15% ethanol liquid as binding agent, general one-tenth pill, control weight is at the 0.12g/ grain;
(11) packing is packed above-mentioned qualified pill in the medicine bottle into racking machine, gets final product;
The percentage by weight of case study on implementation 5 is adjusted into:
Radix Polygoni Multiflori Preparata 18%, Radix Notoginseng 9%, Bulbus Fritillariae Thunbergii 8%, Fructus Trichosanthis 9%, Semen Persicae (parched) 6%, Eupolyphaga Seu Steleophaga 7%, Radix Ginseng Rubra 7.5%, Folium Isatidis 11.5%, Radix Sophorae Tonkinensis 6%, Poria 6%, Semen Descurainiae (parched) 6%, Pericarpium Citri Reticulatae 6%,
Or Radix Polygoni Multiflori Preparata 12%, Radix Notoginseng 4%, Bulbus Fritillariae Thunbergii 5%, Fructus Trichosanthis 9%, Semen Persicae (parched) 9%, Eupolyphaga Seu Steleophaga 9%, Radix Ginseng Rubra 9%, Folium Isatidis 15%, Radix Sophorae Tonkinensis 7%, Poria 7%, Semen Descurainiae (parched) 7%, Pericarpium Citri Reticulatae 7%,
Or Radix Polygoni Multiflori Preparata 16%, Radix Notoginseng 6%, Bulbus Fritillariae Thunbergii 6.5%, Fructus Trichosanthis 7.5%, Semen Persicae (parched) 6.5%, Eupolyphaga Seu Steleophaga 7%, Radix Ginseng Rubra 7.5%, Folium Isatidis 7%, Radix Sophorae Tonkinensis 9%, Poria 9%, Semen Descurainiae (parched) 9%, Pericarpium Citri Reticulatae 9%,
Or Radix Polygoni Multiflori Preparata 19%, Radix Notoginseng 9%, Bulbus Fritillariae Thunbergii 8%, Fructus Trichosanthis 6%, Semen Persicae (parched) 4%, Eupolyphaga Seu Steleophaga 5%, Radix Ginseng Rubra 6%, Folium Isatidis 10%, Radix Sophorae Tonkinensis 8%, Poria 8%, Semen Descurainiae (parched) 8%, Pericarpium Citri Reticulatae 8%;
Alcohol heat reflux extracts, and Radix Ginseng Rubra, Radix Notoginseng, the Folium Isatidis that takes by weighing added 60% or 70% or 80% ethanol 6 or 7 or 8 or 10 times of amounts ...;
Concentrate ... relative density of medicine liquid 1.05 or 1.15 (60 ℃) gets final product;
Mix: ... add 5% or 7% or 10% starch mixing of its weight again;
Pill, ... spraying add the raw material gross weight 30% or 40% or 45% or 50%, concentration is that 10% or 20% or 25% or 30% ethanol liquid is as binding agent, general one-tenth pill, control weight is at 0.1g/ grain or 0.15g/ grain;
It is constant to prepare other steps, can be made into the Chinese patent medicine---pill of the treatment pulmonary carcinoma of four kinds of different components ratios.
Embodiment 6: prepare a kind of Chinese patent medicine for the treatment of pulmonary carcinoma---tablet.
(1) its raw material and W/W are: Radix Polygoni Multiflori Preparata 17%, Radix Notoginseng 6%, Bulbus Fritillariae Thunbergii 8%, Fructus Trichosanthis 7%, Semen Persicae (parched) 9%, Eupolyphaga Seu Steleophaga 8%, Radix Ginseng Rubra 8%, Folium Isatidis 8%, Radix Sophorae Tonkinensis 9%, Poria 7%, Semen Descurainiae (parched) 6%, Pericarpium Citri Reticulatae 7%; Preparation process is:
(2) batching takes by weighing Radix Polygoni Multiflori Preparata 17kg, Radix Notoginseng 6kg, Bulbus Fritillariae Thunbergii 8kg, Fructus Trichosanthis 7kg, Semen Persicae (parched) 9kg, Eupolyphaga Seu Steleophaga 8kg by the percentage by weight of above-mentioned prescription; Radix Ginseng Rubra 8kg, Folium Isatidis 8kg, Radix Sophorae Tonkinensis 9kg, Poria 7kg, Semen Descurainiae (parched) 6kg, Pericarpium Citri Reticulatae 7kg;
(3) pulverize, will get Radix Notoginseng, Bulbus Fritillariae Thunbergii is ground into 100 order left and right sides fine powders with Universalpulverizer, and is standby;
(4) extract volatile oil: with Pericarpium Citri Reticulatae, the Fructus Trichosanthis that takes by weighing, adopt steam distillation to propose volatile oil, collect volatile oil by oil water separator, standby; Aqueous solution device collection in addition concentrates for follow-up merging, and medicinal residues enter down the operation decocting and carry;
(5) alcohol heat reflux extracts: Radix Ginseng Rubra, the Folium Isatidis that takes by weighing added 6~10 times of amounts of 60~80% ethanol, and reflux, extract, 3 times, each 90 minutes, alcohol reflux liquid device collection in addition reclaimed ethanol with concentrated for the back operation, and medicinal residues enter down the operation decocting and carry;
(6) decocting is carried: above-mentioned medicinal residues and all the other Radix Polygoni Multiflori Preparatas, Semen Descurainiae (parched), Semen Persicae (parched), Eupolyphaga Seu Steleophaga, Radix Sophorae Tonkinensis, Poria seven flavors, add 10 times of water gagings, and soaked 60 minutes, decoct 3 times, each 60 minutes, collecting decoction, filter, filtrate and above-mentioned aqueous solution and concentrated solution merge, and concentrate for the back operation;
(7) concentrate: in above-mentioned alcohol reflux liquid suction concentration tank, open the vacuum valve decompression, open steam valve heating recovery ethanol to complete substantially; Medicinal liquid and said extracted liquid merge, and put the triple effect concentration tank altogether, open the steam valve heating, get final product to relative density of medicine liquid 1.10 (60 ℃);
(8) spray drying: above-mentioned concentrated medicament is placed storage tank, open vacuum and heating unit, with suitable speed it is sprayed in the drying tower again, collect dry thing, promptly get dry extract;
(9) granulate: after Radix Notoginseng, Bulbus Fritillariae Thunbergii powder and the above-mentioned dry extract that pulverizing is obtained places the one-step-granulating method mix homogeneously, add 7% starch of its weight again, spraying adds an amount of 30% ethanol liquid granulates as binding agent, after dry;
(10) granulate: with granulated material, sift out coarse grain with 16 eye mesh screens, coarse grain is put granulate in the pelletizing machine, reuse 16 eye mesh screens sieve behind the granulate;
(11) mix: the volatile oil spraying that extraction is obtained is mixed in the above-mentioned dried granule, just mixes by hand while spray earlier, adds the medicinal carboxymethylstach sodium and 1.0% Pulvis Talci of its weight 1.0% again, puts to mix in the batch mixer promptly to can be made into tablet in 10 minutes.
The percentage by weight of case study on implementation 6 is adjusted into:
Radix Polygoni Multiflori Preparata 18%, Radix Notoginseng 9%, Bulbus Fritillariae Thunbergii 8%, Fructus Trichosanthis 9%, Semen Persicae (parched) 6%, Eupolyphaga Seu Steleophaga 7%, Radix Ginseng Rubra 7.5%, Folium Isatidis 11.5%, Radix Sophorae Tonkinensis 6%, Poria 6%, Semen Descurainiae (parched) 6%, Pericarpium Citri Reticulatae 6%,
Or Radix Polygoni Multiflori Preparata 12%, Radix Notoginseng 4%, Bulbus Fritillariae Thunbergii 5%, Fructus Trichosanthis 9%, Semen Persicae (parched) 9%, Eupolyphaga Seu Steleophaga 9%, Radix Ginseng Rubra 9%, Folium Isatidis 15%, Radix Sophorae Tonkinensis 7%, Poria 7%, Semen Descurainiae (parched) 7%, Pericarpium Citri Reticulatae 7%,
Or Radix Polygoni Multiflori Preparata 16%, Radix Notoginseng 6%, Bulbus Fritillariae Thunbergii 6.5%, Fructus Trichosanthis 7.5%, Semen Persicae (parched) 6.5%, Eupolyphaga Seu Steleophaga 7%, Radix Ginseng Rubra 7.5%, Folium Isatidis 7%, Radix Sophorae Tonkinensis 9%, Poria 9%, Semen Descurainiae (parched) 9%, Pericarpium Citri Reticulatae 9%,
Or Radix Polygoni Multiflori Preparata 19%, Radix Notoginseng 9%, Bulbus Fritillariae Thunbergii 8%, Fructus Trichosanthis 6%, Semen Persicae (parched) 4%, Eupolyphaga Seu Steleophaga 5%, Radix Ginseng Rubra 6%, Folium Isatidis 10%, Radix Sophorae Tonkinensis 8%, Poria 8%, Semen Descurainiae (parched) 8%, Pericarpium Citri Reticulatae 8%;
Alcohol heat reflux extracts, and Radix Ginseng Rubra, Radix Notoginseng, the Folium Isatidis that takes by weighing added 60% or 70% or 80% ethanol 6 or 7 or 8 or 10 times of amounts;
Concentrate ... relative density of medicine liquid 1.05 or 1.15 (60 ℃) gets final product;
Granulate: ... add 5~10% starch of its weight again, spraying adds an amount of 15%~40% ethanol liquid granulates as binding agent, dry back;
Granulate: ... sift out coarse grain with 12 orders or 14 orders or 18 orders or 20 eye mesh screens, coarse grain is put granulate in the pelletizing machine, reuse 12 orders or 14 orders or 18 orders or 20 eye mesh screens sieve behind the granulate;
Mix: ... add the medicinal carboxymethylstach sodium and 0.5% or 1.5% Pulvis Talci of its weight 0.5% or 1.5% or 2.5% or 3% again, put to mix in the batch mixer and got final product in 5 minutes or 15 minutes.
It is constant to prepare other steps, can be made into the Chinese patent medicine---tablet of the treatment pulmonary carcinoma of four kinds of different components ratios.