CN115252726A - Biological traditional Chinese medicine preparation for reducing blood pressure and preparation method thereof - Google Patents
Biological traditional Chinese medicine preparation for reducing blood pressure and preparation method thereof Download PDFInfo
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- CN115252726A CN115252726A CN202211050240.3A CN202211050240A CN115252726A CN 115252726 A CN115252726 A CN 115252726A CN 202211050240 A CN202211050240 A CN 202211050240A CN 115252726 A CN115252726 A CN 115252726A
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- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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Abstract
The invention relates to the technical field of biological medicines, and discloses a biological traditional Chinese medicine preparation for reducing blood pressure and a preparation method thereof, wherein the biological traditional Chinese medicine preparation is prepared from the following raw materials in parts by mass: 6-8 parts of selfheal, 2-5 parts of boxthorn leaf, 4-7 parts of mulberry leaf, 3-8 parts of lobular lotus, 2-5 parts of spina date seed, 3-7 parts of rhizoma polygonati and 5-8 parts of coptis chinensis. The biological traditional Chinese medicine preparation for reducing blood pressure has good curative effect on hypertension patients in different periods, the blood pressure of the middle-heavy hypertension patients is basically stabilized within one month by taking the biological traditional Chinese medicine preparation, the patients can be cured within two to three months, and the biological traditional Chinese medicine preparation is not repeated after taking the medicine, has no medicine dependence, does not need to be taken for the whole life compared with the traditional self-used antihypertensive medicine, has the functions of calming the liver, suppressing yang, promoting blood circulation, removing blood stasis, eliminating phlegm, resolving dampness, calming the heart, tranquilizing the mind and nourishing the liver and kidney, has obvious effect, simple preparation process, easy mass production and is worthy of popularization and application.
Description
Technical Field
The invention relates to the technical field of biological medicines, in particular to a biological traditional Chinese medicine preparation for reducing blood pressure and a preparation method thereof.
Background
Hypertension is a clinical syndrome which is mainly characterized in that the systemic arterial blood pressure is increased, wherein the systolic pressure is more than or equal to 140 mm Hg, the diastolic pressure is more than or equal to 90 mm Hg, the clinical syndrome can be accompanied with functional or organic damage of organs such as heart, brain, kidney and the like, and the hypertension is the most common chronic disease and is also the most main risk factor of cardiovascular and cerebrovascular diseases.
The existing medicines for treating hypertension generally cannot be taken for a long time without root hypertension, so that money and money of patients are wasted, other complications of the patients can be caused by long-term taking, and the traditional Chinese medicine has the advantages of small side effect and thorough treatment compared with western medicines, so that how to develop a traditional Chinese medicine preparation with stable blood pressure reduction and no recurrence by using a biological medicine technology becomes an important problem, and in order to solve the problems, a biological traditional Chinese medicine preparation for reducing blood pressure and a preparation method thereof are provided.
Disclosure of Invention
Aiming at the defects of the prior art, in order to solve the problems, the invention provides the following technical scheme: a biological traditional Chinese medicine preparation for reducing blood pressure is prepared from the following raw materials in parts by weight: 6-8 parts of selfheal, 2-5 parts of boxthorn leaf, 4-7 parts of mulberry leaf, 3-8 parts of lobular lotus, 2-5 parts of spina date seed, 3-7 parts of rhizoma polygonati, 5-8 parts of coptis chinensis, 2-5 parts of flatstem milkvetch seed, 3-5 parts of tartary buckwheat, 2-5 parts of kudzu root, 1-3 parts of coconut, 5-7 parts of rhizoma gastrodiae, 5-10 parts of chicory, 0.1-0.5 part of radix bupleuri, 1-1.5 parts of chrysanthemum, 0.5-1 part of corn stigma, 1-3 parts of poria cocos, 0.5-1 part of astragalus membranaceus and 2-5 parts of eucommia ulmoides.
The health-care food is prepared from the following raw materials in parts by weight: 7 parts of selfheal, 4 parts of boxthorn leaf, 5 parts of mulberry leaf, 5 parts of lobular lotus, 4 parts of spina date seed, 5 parts of rhizoma polygonati, 7 parts of coptis chinensis, 3 parts of flastem milkvetch seed, 4 parts of tartary buckwheat, 3 parts of kudzu root, 2 parts of coconut, 6 parts of tall gastrodia tuber, 7 parts of chicory, 0.3 part of radix bupleuri, 1.2 parts of chrysanthemum, 0.8 part of corn stigma, 2 parts of tuckahoe, 0.7 part of astragalus mongholicus and 3 parts of eucommia ulmoides.
A preparation method of a biological traditional Chinese medicine preparation for reducing blood pressure comprises the following steps:
s1, firstly, respectively weighing the raw materials in parts by weight;
s2, cleaning the selfheal, the boxthorn leaves, the mulberry leaves, the lobular lotus and the spina date seeds with purified water, naturally airing, removing impurities, and crushing into coarse powder for later use;
s3, soaking the sealwort, the coptis chinensis, the flatstem milkvetch seed, the tartary buckwheat and the kudzuvine root in purified water for 2-3 days, extracting to obtain an extracting solution, and finally heating and concentrating to obtain thick paste A for later use;
s4, cleaning and drying coconut, gastrodia elata, chicory, radix bupleuri, chrysanthemum, corn stigma, poria cocos, astragalus membranaceus and eucommia ulmoides, cooling to room temperature, placing the mixture into a grinder, primarily grinding the mixture into 100 meshes to obtain a mixture, performing reflux extraction for 2 times by using water, wherein the time is not less than 1 hour each time, combining all filtrates, filtering, and finally heating and concentrating the filtrate into thick paste B for later use;
s5, putting the coarse powder in the step S2, the thick paste A in the step S3 and the thick paste B in the step S4 into a stirring container, adding a proper amount of warm water at 50-70 ℃, uniformly mixing, and then stirring for 20-30 minutes;
s6, drying by using a dryer, adding preparation forming auxiliary materials, drying, and pressing into tablets.
Furthermore, the particle size of the coarse powder in the step S2 is 150-300 meshes.
Further, the extraction process of step S3 is divided into two extractions, one extraction: adding purified water of 30-40 deg.C into an extraction tank, soaking for 1 hr, boiling, decocting with slow fire for 1-2 hr, and filtering to obtain primary filtrate and primary residue; secondary extraction: adding appropriate amount of purified water into the primary filter residue, decocting with strong fire for 30-40 min, pumping, filtering to obtain secondary filtrate and secondary filter residue, discarding the secondary filter residue, and mixing the two filtrates to obtain extractive solution.
Pharmacological description:
selfheal: clear heat and purge fire, improve vision, dissipate stagnation and relieve swelling.
Wolfberry leaves: tonify liver and kidney, promote the production of body fluid to quench thirst, dispel wind and remove dampness, activate blood circulation to dissipate blood stasis, treat consumptive disease fever, polydipsia, conjunctival congestion, dizziness, nebula nyctalopia, metrorrhagia, leukorrhagia, heat-toxin sores and swelling.
Mulberry leaf: it is cold in nature, sweet and bitter in taste, has effects of dispelling pathogenic wind and heat, clearing lung-heat, moistening dryness, removing liver fire, and improving eyesight, and can be used for treating wind-heat type common cold, lung heat type cough, dizziness, headache, conjunctival congestion, and dim eyesight.
And (3) fructus podophylli: has effects of regulating menstruation and promoting blood circulation, and can be used for treating amenorrhea due to blood stasis.
And (2) spina date seed: has the effects of nourishing heart and liver, calming heart and tranquilizing mind, arresting sweating and promoting fluid production, and is commonly used for treating dysphoria, insomnia, palpitation due to fright, dreaminess, asthenia, hyperhidrosis, body fluid consumption and thirst.
And (3) sealwort: has sweet and refreshing taste, and can be used for treating weakness of spleen and stomach, asthenia, xerostomia, cough due to lung deficiency, essence and blood deficiency, internal heat, diabetes, etc., and treating pulmonary tuberculosis and tinea mycosis.
Coptis root: clearing heat, eliminating dampness, purging pathogenic fire, removing toxic substances, and can be used for treating damp-heat, abdominal fullness, emesis, acid regurgitation, dysentery, jaundice, hyperpyrexia, unconsciousness, vexation, insomnia, hematemesis, epistaxis, conjunctival congestion, toothache, diabetes, carbuncle, swelling, and furuncle; it is used externally to treat eczema, eczema and purulent ear canal.
Flatstem milkvetch seed: has the functions of invigorating kidney, strengthening Yang, arresting seminal emission, reducing urination, nourishing liver and improving eyesight.
Buckwheat: bitter and neutral in taste, can' excess intestines and stomach, benefit strength, continue spirit, benefit ears and eyes, and refine filth in five internal organs.
Kudzu root: has the functions of relieving muscles and allaying fever, promoting eruption, promoting the production of body fluid to quench thirst, and invigorating yang to arrest diarrhea, and is commonly used for fever with exterior syndrome, strong pain of neck and back, measles without adequate eruption, thirst due to febrile disease, thirst due to yin deficiency, heat diarrhea and dysentery, and diarrhea due to spleen deficiency.
Coconut: contains vitamin B1, vitamin E, vitamin C, potassium, calcium, magnesium, etc., and various trace elements.
Gastrodia elata: has effects of calming endogenous wind, relieving spasm, suppressing liver yang, dispelling pathogenic wind, dredging collaterals, and treating stirring of liver wind, convulsive epilepsy, convulsion, giddiness, headache, limbs anesthesia, hand and foot paralysis, rheumatalgia, etc.
Chicory: slightly bitter and salty taste, cool nature, liver heat clearing, gallbladder benefiting, stomach invigorating, digestion promoting, diuresis inducing, and repercussive.
Bupleurum root: is bitter in nature and slightly cold in nature, enters liver and gallbladder meridians, and has the effects of harmonizing exterior and interior, soothing liver and invigorating yang.
Chrysanthemum: bitter and sweet in taste, slightly cold in nature, capable of dispelling wind and clearing heat, calming liver and improving eyesight, and clearing heat and toxic materials.
Corn silk: sweet and light taste, mild nature, and has the effects of promoting urination, relieving swelling, clearing liver-fire and promoting bile flow.
Tuckahoe, poria cocos: sweet and bland in flavor, neutral in nature, promoting diuresis and excreting dampness, invigorating spleen and calming heart.
Astragalus root: enhancing organism immunity, protecting liver, promoting urination, resisting aging, resisting stress, lowering blood pressure, and broad antibacterial effect.
Eucommia ulmoides: the eucommia bark, cortex Eucommiae, with its sweet and warm nature and taste, enters liver and kidney meridians, and has the main effects of tonifying liver and kidney, strengthening tendons and bones, and preventing miscarriage.
The Chinese medicinal preparation has the following use method and dosage: 2 tablets each time, twice a day, and once after half an hour of breakfast and supper.
Compared with the prior art, the invention provides a biological traditional Chinese medicine preparation for reducing blood pressure and a preparation method thereof, and the biological traditional Chinese medicine preparation has the following beneficial effects:
the biological traditional Chinese medicine preparation for reducing blood pressure has good curative effect on hypertension patients in different periods, the blood pressure of the middle-heavy hypertension patients is basically stabilized within one month by taking the biological traditional Chinese medicine preparation, the patients can be cured within two to three months, and the biological traditional Chinese medicine preparation is not repeated after taking the medicine, has no medicine dependence, does not need to be taken for the whole life compared with the traditional self-used antihypertensive medicine, has the functions of calming the liver, suppressing yang, promoting blood circulation, removing blood stasis, eliminating phlegm, resolving dampness, calming the heart, tranquilizing the mind and nourishing the liver and kidney, has obvious effect, simple preparation process, easy mass production and is worthy of popularization and application.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the following embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without making any creative effort based on the embodiments in the present invention, belong to the protection scope of the present invention.
The embodiment of the biological traditional Chinese medicine preparation for reducing blood pressure and the preparation method thereof is as follows:
example one
A biological traditional Chinese medicine preparation for reducing blood pressure is prepared from the following raw materials in parts by weight: 6 parts of selfheal, 2 parts of boxthorn leaves, 4 parts of mulberry leaves, 3 parts of lobular lotus, 2 parts of spina date seeds, 3 parts of sealwort, 5 parts of coptis chinensis, 2 parts of flatstem milkvetch seeds, 3 parts of tartary buckwheat, 2 parts of kudzu roots, 1 part of coconuts, 5 parts of gastrodia elata, 5 parts of chicory, 0.1 part of radix bupleuri, 1 part of chrysanthemum, 0.5 part of corn stigma, 1 part of poria cocos, 0.5 part of astragalus membranaceus and 2 parts of eucommia ulmoides.
A preparation method of a biological traditional Chinese medicine preparation for reducing blood pressure comprises the following steps:
s1, firstly, respectively weighing the raw materials in parts by weight;
s2, cleaning the selfheal, the boxthorn leaves, the mulberry leaves, the lobular lotus and the spina date seeds with purified water, naturally airing, removing impurities, and crushing into coarse powder for later use;
s3, soaking the sealwort, the coptis chinensis, the flatstem milkvetch seed, the tartary buckwheat and the kudzuvine root in purified water for 2-3 days, extracting to obtain an extracting solution, and finally heating and concentrating to obtain thick paste A for later use;
s4, cleaning and drying coconut, gastrodia elata, chicory, radix bupleuri, chrysanthemum, corn stigma, poria cocos, astragalus membranaceus and eucommia ulmoides, cooling to room temperature, placing the mixture into a pulverizer to be primarily pulverized into 100 meshes to obtain a mixture, performing reflux extraction on the mixture for 2 times by water, wherein the time of each reflux extraction is not less than 1 hour, combining all filtrates, filtering, and finally heating and concentrating the filtrate into a thick paste B for later use;
s5, putting the coarse powder in the step S2, the thick paste A in the step S3 and the thick paste B in the step S4 into a stirring container, adding a proper amount of warm water at 50-70 ℃, uniformly mixing, and then stirring for 20-30 minutes;
s6, drying by using a dryer, adding preparation forming auxiliary materials, drying, and pressing into tablets.
Furthermore, the particle size of the coarse powder in the step S2 is 150-300 meshes.
Further, the extraction process of step S3 is divided into two extractions, one extraction: adding purified water of 30-40 deg.C into an extraction tank, soaking for 1 hr, boiling, decocting with slow fire for 1-2 hr, and filtering to obtain primary filtrate and primary residue; secondary extraction: adding appropriate amount of purified water into the primary filter residue, decocting with strong fire for 30-40 min, pumping, filtering to obtain secondary filtrate and secondary filter residue, discarding the secondary filter residue, and mixing the two filtrates to obtain extractive solution.
Example two
A biological traditional Chinese medicine preparation for reducing blood pressure is prepared from the following raw materials in parts by weight: 7 parts of selfheal, 4 parts of boxthorn leaf, 5 parts of mulberry leaf, 5 parts of lobular lotus, 4 parts of spina date seed, 5 parts of rhizoma polygonati, 7 parts of coptis chinensis, 3 parts of flatstem milkvetch seed, 4 parts of tartary buckwheat, 3 parts of kudzu root, 2 parts of coconut, 6 parts of tall gastrodia tuber, 7 parts of chicory, 0.3 part of radix bupleuri, 1.2 parts of chrysanthemum, 0.8 part of corn stigma, 2 parts of poria cocos, 0.7 part of astragalus mongholicus and 3 parts of eucommia ulmoides.
A preparation method of a biological traditional Chinese medicine preparation for reducing blood pressure comprises the following steps:
s1, firstly, respectively weighing the raw materials in parts by weight;
s2, cleaning the selfheal, the boxthorn leaves, the mulberry leaves, the lobular lotus and the spina date seeds with purified water, naturally airing, removing impurities, and crushing into coarse powder for later use;
s3, soaking the sealwort, the coptis chinensis, the flatstem milkvetch seed, the tartary buckwheat and the kudzuvine root in purified water for 2-3 days, extracting to obtain an extracting solution, and finally heating and concentrating to obtain thick paste A for later use;
s4, cleaning and drying coconut, gastrodia elata, chicory, radix bupleuri, chrysanthemum, corn stigma, poria cocos, astragalus membranaceus and eucommia ulmoides, cooling to room temperature, placing the mixture into a pulverizer to be primarily pulverized into 100 meshes to obtain a mixture, performing reflux extraction on the mixture for 2 times by water, wherein the time of each reflux extraction is not less than 1 hour, combining all filtrates, filtering, and finally heating and concentrating the filtrate into a thick paste B for later use;
s5, putting the coarse powder in the step S2, the thick paste A in the step S3 and the thick paste B in the step S4 into a stirring container, adding a proper amount of warm water at 50-70 ℃, uniformly mixing, and then stirring for 20-30 minutes;
s6, drying by using a dryer, adding preparation forming auxiliary materials, drying, and pressing into tablets.
Furthermore, the particle size of the coarse powder in the step S2 is 150-300 meshes.
Further, the extraction process of step S3 is divided into two extractions, one extraction: adding purified water of 30-40 deg.C into an extraction tank, soaking for 1 hr, boiling, decocting with slow fire for 1-2 hr, and filtering to obtain primary filtrate and primary residue; secondary extraction: adding appropriate amount of purified water into the first residue, decocting with strong fire for 30-40 min, pumping, filtering to obtain secondary filtrate and secondary residue, discarding the secondary residue, and mixing the two filtrates to obtain extractive solution.
EXAMPLE III
A biological traditional Chinese medicine preparation for reducing blood pressure is prepared from the following raw materials in parts by weight: 8 parts of selfheal, 5 parts of boxthorn leaf, 7 parts of mulberry leaf, 8 parts of lobular lotus, 5 parts of spina date seed, 7 parts of rhizoma polygonati, 8 parts of coptis chinensis, 5 parts of flatstem milkvetch seed, 5 parts of tartary buckwheat, 5 parts of kudzu root, 3 parts of coconut, 7 parts of gastrodia elata, 10 parts of chicory, 0.5 part of radix bupleuri, 1.5 parts of chrysanthemum, 1 part of corn stigma, 3 parts of poria cocos, 1 part of astragalus membranaceus and 5 parts of eucommia ulmoides.
A preparation method of a biological traditional Chinese medicine preparation for reducing blood pressure comprises the following steps:
s1, firstly, respectively weighing the raw materials in parts by weight;
s2, cleaning the selfheal, the boxthorn leaves, the mulberry leaves, the lobular lotus and the spina date seeds with purified water, naturally airing, removing impurities, and crushing into coarse powder for later use;
s3, soaking rhizoma polygonati, coptis chinensis, semen astragali complanati, tartary buckwheat and radix puerariae in purified water for 2-3 days, extracting to obtain an extracting solution, and finally heating and concentrating to obtain thick paste A for later use;
s4, cleaning and drying coconut, gastrodia elata, chicory, radix bupleuri, chrysanthemum, corn stigma, poria cocos, astragalus membranaceus and eucommia ulmoides, cooling to room temperature, placing the mixture into a grinder, primarily grinding the mixture into 100 meshes to obtain a mixture, performing reflux extraction for 2 times by using water, wherein the time is not less than 1 hour each time, combining all filtrates, filtering, and finally heating and concentrating the filtrate into thick paste B for later use;
s5, putting the coarse powder in the step S2, the thick paste A in the step S3 and the thick paste B in the step S4 into a stirring container, adding a proper amount of warm water at 50-70 ℃, uniformly mixing, and then stirring for 20-30 minutes;
s6, drying by using a dryer, adding preparation forming auxiliary materials, drying, and pressing into tablets.
Furthermore, the particle size of the coarse powder in the step S2 is 150-300 meshes.
Further, the extraction process of step S3 is divided into two extractions, one extraction: adding purified water of 30-40 deg.C into an extraction tank, soaking for 1 hr, boiling, decocting with slow fire for 1-2 hr, and filtering to obtain primary filtrate and primary residue; secondary extraction: adding appropriate amount of purified water into the primary filter residue, decocting with strong fire for 30-40 min, pumping, filtering to obtain secondary filtrate and secondary filter residue, discarding the secondary filter residue, and mixing the two filtrates to obtain extractive solution.
Clinical experiments on blood pressure reduction: the experimental subjects are patients with long-term hypertension with blood pressure of 140-179mmHg, 400 patients are randomly divided into 4 groups, each group has 100 patients, the first 3 groups are respectively taken with the Chinese medicinal formula of examples 1-3 every day, and the fourth group is a control group taken with common antihypertensives.
The therapeutic effect judgment standard is as follows: the evaluation criteria of the curative effect are as follows: (1) curing: the blood pressure is reduced to 120/80mmHg, the disease does not rebound after 3 years of stopping the medicine, and the hypertension symptom completely disappears; (2) improvement: the blood pressure fluctuates between 120-130 mmHg/90-98 mmHg, and hypotensor needs to be taken along with the rise of blood pressure, so that the hypertension symptoms mostly disappear, and headache and dizziness are occasionally caused. And (3) invalidation: the blood pressure is still above 130/100mmHg, and hypotensive drug is still needed, so the hypertension symptoms do not disappear, and headache and dizziness are often caused. The results of the experiments are shown in the following table:
as can be seen from the above table, the biological traditional Chinese medicine preparations 1 to 3 for reducing blood pressure of the present invention have good curative effects on patients with hypertension at different periods, and the administration of the traditional Chinese medicine preparations of the present invention 1 to 3 basically stabilizes blood pressure within one month for patients with moderate or severe hypertension, can heal the disease in two to three months, and is not repeated after withdrawal of the drug, and has no drug dependence.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (5)
1. A biological traditional Chinese medicine preparation for reducing blood pressure is characterized in that: the feed is prepared from the following raw materials in parts by weight: 6-8 parts of selfheal, 2-5 parts of boxthorn leaf, 4-7 parts of mulberry leaf, 3-8 parts of lobular lotus, 2-5 parts of spina date seed, 3-7 parts of rhizoma polygonati, 5-8 parts of coptis chinensis, 2-5 parts of flatstem milkvetch seed, 3-5 parts of tartary buckwheat, 2-5 parts of kudzu root, 1-3 parts of coconut, 5-7 parts of rhizoma gastrodiae, 5-10 parts of chicory, 0.1-0.5 part of radix bupleuri, 1-1.5 parts of chrysanthemum, 0.5-1 part of corn stigma, 1-3 parts of poria cocos, 0.5-1 part of astragalus membranaceus and 2-5 parts of eucommia ulmoides.
2. The biological traditional Chinese medicine preparation for reducing blood pressure according to claim 1, characterized in that: the feed is prepared from the following raw materials in parts by weight: 7 parts of selfheal, 4 parts of boxthorn leaf, 5 parts of mulberry leaf, 5 parts of lobular lotus, 4 parts of spina date seed, 5 parts of rhizoma polygonati, 7 parts of coptis chinensis, 3 parts of flatstem milkvetch seed, 4 parts of tartary buckwheat, 3 parts of kudzu root, 2 parts of coconut, 6 parts of tall gastrodia tuber, 7 parts of chicory, 0.3 part of radix bupleuri, 1.2 parts of chrysanthemum, 0.8 part of corn stigma, 2 parts of poria cocos, 0.7 part of astragalus mongholicus and 3 parts of eucommia ulmoides.
3. A method for preparing a biological traditional Chinese medicine preparation for reducing blood pressure, which adopts the biological traditional Chinese medicine preparation for reducing blood pressure of any one of claims 1-2, and is characterized in that: the preparation process includes the following steps:
s1, firstly, respectively weighing the raw materials in parts by weight;
s2, cleaning the selfheal, the boxthorn leaves, the mulberry leaves, the lobular lotus and the spina date seeds with purified water, naturally airing, removing impurities, and crushing into coarse powder for later use;
s3, soaking the sealwort, the coptis chinensis, the flatstem milkvetch seed, the tartary buckwheat and the kudzuvine root in purified water for 2-3 days, extracting to obtain an extracting solution, and finally heating and concentrating to obtain thick paste A for later use;
s4, cleaning and drying coconut, gastrodia elata, chicory, radix bupleuri, chrysanthemum, corn stigma, poria cocos, astragalus membranaceus and eucommia ulmoides, cooling to room temperature, placing the mixture into a pulverizer to be primarily pulverized into 100 meshes to obtain a mixture, performing reflux extraction on the mixture for 2 times by water, wherein the time of each reflux extraction is not less than 1 hour, combining all filtrates, filtering, and finally heating and concentrating the filtrate into a thick paste B for later use;
s5, putting the coarse powder in the step S2, the thick paste A in the step S3 and the thick paste B in the step S4 into a stirring container, adding a proper amount of warm water at 50-70 ℃, uniformly mixing, and then stirring for 20-30 minutes;
s6, drying by using a dryer, adding preparation forming auxiliary materials, drying, and pressing into tablets.
4. A preparation method of a biological traditional Chinese medicine preparation for reducing blood pressure is characterized by comprising the following steps: the granularity of the coarse powder in the step S2 is 150-300 meshes.
5. A preparation method of a biological traditional Chinese medicine preparation for reducing blood pressure is characterized by comprising the following steps: the extraction processing of the step S3 is divided into two times of extraction, and the first time of extraction is as follows: adding purified water of 30-40 deg.C into an extraction tank, soaking for 1 hr, boiling, decocting with slow fire for 1-2 hr, and filtering to obtain primary filtrate and primary residue; secondary extraction: adding appropriate amount of purified water into the primary filter residue, decocting with strong fire for 30-40 min, pumping, filtering to obtain secondary filtrate and secondary filter residue, discarding the secondary filter residue, and mixing the two filtrates to obtain extractive solution.
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2022
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Application publication date: 20221101 |