CN115252717A - Wuyi ointment suitable for people with qi deficiency constitution, preparation method and application thereof - Google Patents

Abstract

The invention relates to the technical field of ointment prescriptions, and discloses a Wuyi ointment suitable for people with qi deficiency constitution, a preparation method and application thereof, and a Wuyi ointment suitable for people with qi deficiency constitution, which is characterized in that it is composed of the following parts by weight The crude drug is prepared: 120-180 parts of Polygonatum japonica, 150-200 parts of Astragalus (baked), 150-200 parts of Atractylodes Rhizoma, 120-180 parts of Shudi, and 120-180 parts of Lycium barbarum; a kind of Wuyi ointment provided by the application The preparation method thereof is prepared from two raw materials: Chinese herbal decoction pieces and Chinese herbal formula granules. Since the raw materials contain more polysaccharide substances, temperature control is performed in the concentration process, which greatly reduces the caramelization reaction, improves the quality of the ointment, and ensures the taste of the ointment. .

Description

Wuyi ointment suitable for people with qi deficiency constitution, preparation method and application thereof

technical field

The invention relates to the technical field of ointments, in particular to a Wuyi ointment suitable for people with qi-deficiency constitution, a preparation method and application thereof.

Background technique

Ointment (also known as ointment or decoction) is one of the eight common dosage forms of traditional Chinese medicine. It originated in the Spring and Autumn and Warring States Periods. The book "Huangdi Neijing" recorded hog ointment and horse ointment. With the improvement of living standards and the enhancement of health awareness, the idea of traditional Chinese medicine to prevent diseases has been deeply rooted in the hearts of the people.

The current preventive health care system can no longer meet people's needs well, and the work of traditional Chinese medicine to prevent diseases is becoming more and more important. The traditional Chinese medicine ointment developed under the guidance of the theory of "Preventive Treatment of Diseases" in traditional Chinese medicine has the characteristics of multi-targets, low efficacy, moderate efficacy, and long-lasting stability. It has the effects of strengthening the foundation, correcting deviations and eliminating diseases, anti-aging and prolonging life. Strengthening the development, research and practical exploration of TCM ointments can not only enrich and improve the theoretical achievements of TCM ointments, promote the clinical application of TCM ointments, but also inherit and promote the culture of TCM. The theoretical and practical results of traditional Chinese medicine ointment prescriptions are increasing day by day, and the scope of clinical application continues to expand and presents obvious specialist characteristics. However, the research on the use of traditional Chinese medicine classic prescriptions to regulate people with biased constitutions is still relatively rare, and there is no one suitable for people with Qi-deficiency constitutions. of Wuyi Cream.

Contents of the invention

The purpose of the present invention is to invent Wuyi ointment suitable for people with qi deficiency physique according to the theory of "preventive treatment of disease" in traditional Chinese medicine;

Another object of the present invention is to provide a preparation method of the Wuyi Ointment suitable for people with qi-deficiency constitution;

Another object of the present invention is to provide the application of the Wuyi Ointment suitable for people with Qi-deficiency constitution.

For realizing above-mentioned first object, the technical scheme that the present invention takes is:

A kind of Wuyi ointment suitable for people with qi deficiency constitution, which is prepared from the following raw materials in proportion by weight: Polygonatum Polygonatum 120-180 parts, Radix Astragali (burnt) 150-200 parts, Atractylodes macrocephala 150-200 parts, Rehmannia glutinosa 120-180 parts parts, 120-180 parts of medlar.

Preferably, Wuyi Paste is prepared from the raw materials in the following proportions by weight: Polygonatum Polygonatum 120-180 parts, Radix Astragali (burnt) 180-200 parts, Atractylodes Rhizoma Atractylodes Rhizome 180-200 parts, Rehmannia glutinosa 120-150 parts, Lycium barbarum 120-200 parts 150 servings.

More preferably, Wuyi ointment is prepared from the raw materials in the following proportions by weight: Polygonatum 150 parts, Radix Astragali (burned) 180 parts, Atractylodes macrocephala 180 parts, Rehmannia glutinosa 150 parts, and Fructus Lycium barbarum 150 parts.

For realizing above-mentioned second purpose, the technical scheme that the present invention takes is:

The preparation method of Wuyi ointment suitable for Qi-deficiency constitution as described in any one of the above is as follows:

(1) A preparation method using Chinese herbal decoction pieces as raw materials.

A preparation method of Wuyi ointment suitable for qi-deficiency constitution, the steps include soaking, decocting, concentrating, collecting the ointment, cooling the ointment, and the preparation method includes the following steps:

The first step of weighing: weighing the raw material components in the form of each Chinese herbal decoction piece according to the distribution ratio of the raw material components of Wuyi Gao according to any one of claims 1-3;

The second step of water extraction: put all the raw material components into a clean casserole, copper pot or stainless steel pot with equivalent capacity, and completely immerse the medicinal materials with 6 to 12 times the amount of water (for decocting the head juice for medicinal purposes), soaking time 1 hour; heat and decoct the soaked medicinal materials, first boil at 100°C, and then simmer for about 1 to 2 hours. At this time, the medicinal juice becomes thicker, and the first medicinal juice can be filtered out with gauze or a 24-40 mesh sieve , add 6 times the amount of water to decoct, the decoction method is the same as before, boil with strong fire, and then decoct with slow fire for about 1 hour, this is the second decoction; after filtering the medicinal juice, discard the medicinal residue; Mix, let stand, and then precipitate and filter or filter with a 100-mesh sieve;

Step 3 Concentration: Pour the filtered medicinal juice into a pot for concentration. You can use strong fire first to speed up the evaporation of water, and skim off the foam at any time to make the medicinal juice slowly thicken, and use a slow fire (85 ℃) is further concentrated. At this time, it should be stirred continuously until the medicine juice drips on the paper and does not disperse. At this time, the torment can be suspended. This is the concentrated clear paste, which is concentrated to a relative density of 1.02 -1.05 clear ointment, concentration temperature 70-90°C, weigh the weight of the clear ointment;

The fourth step is to collect the ointment: put the amount of honey into the ointment according to the weight of the ointment: honey weight = 1: 0.4 ~ 0.5, pour it into the ointment, put it on a small fire and simmer slowly, and stir it continuously with a shovel until it is concentrated to the liquid "Fish eye bubbles" can be pulled into flags or dripped into beads (drop the paste into clear water to condense into beads and not disperse);

The fifth step of canning: After the collected paste is cooled, put it into a clean porcelain wide-mouth container, cover the mouth of the container with clean gauze, and let it stand overnight. After it is completely cooled, add Cover and refrigerate.

Further, after the fifth canning step, the preparation method further includes:

The sixth step of quality inspection: conduct quality inspection of Wuyi ointment. Appearance The paste should be fine in texture, suitable in consistency, free from froth, rancidity and mildew.

Further, after the sixth canning step, the preparation method further includes:

The seventh step is labeling: the medicinal liquid is concentrated to collect the ointment, and it can be packaged after it is cooled slightly and there is no water vapor, and the ointment instructions are attached, and the label is attached.

(2) A preparation method using traditional Chinese medicine granules as a raw material.

A preparation method of Wuyi ointment suitable for qi-deficiency constitution, the steps include preheating, dissolving, concentrating, collecting ointment, cooling ointment process, and the preparation method comprises:

The first step of weighing: according to the ratio of raw materials of Wuyi Paste described in any one of claims 1-3, each Chinese medicine raw material granule (converted into particle weight according to the particle standard) is weighed, and each Chinese medicine raw material granule that is cleaned is put into the ointment In the liner of the square machine, fully submerge the medicinal material with 1.5 times the amount of water;

The second step is to set the ointment cooking program: turn on the equipment of the granule ointment square machine, enter the setting interface, set preheating (preheating is required for dissolving in cold water, and no preheating is required for dissolving in hot water), dissolving (dissolving at 70°C for 10 minutes), and concentrating (concentration temperature 80-90°C, time 15-20 minutes), cream collection (temperature 80-90°C, time 10-15 minutes) process flow and time, gear (temperature) and stirring speed of each process, parameter setting Return to the main interface after completion, start operation, automatically heat and stir, start to boil the paste, concentrate to a clear paste with a relative density of 1.02-1.05, the concentration temperature is 70-90°C, and weigh the weight of the clear paste;

The third step of concentration: when starting the cream collection process, pour in honey according to particle weight: honey weight = 1: 0.4-0.5, continue heating and stirring, and run the machine. After the machine is finished, the liquid will form "fish eye bubbles" , can be pulled into flags or dripped into beads (drop the cream juice into clear water to condense into beads and not disperse);

The fourth step is to cool the ointment: after the collected ointment is cooled, put it into a clean porcelain wide-mouth container, cover the container mouth with clean gauze, and let it stand overnight. After it is completely cooled, add Cover and refrigerate.

Further, after the fourth cold paste step, the preparation method also includes:

The fifth step of quality inspection: Appearance The paste should be fine in texture, suitable in consistency, free from floating foam, rancidity and mildew.

Further, after the fifth step of quality inspection, the preparation method further includes:

The sixth step is labeling: the medicinal liquid is concentrated and the ointment is collected, and it can be packaged after it is cooled slightly and there is no water vapor.

The present application also provides an application of the above-mentioned Wuyi ointment in the preparation of medicines for conditioning and improving Qi-deficiency constitution.

The beneficial effects of the present invention are: the present application, according to the theory of "preventive treatment of disease" in traditional Chinese medicine, invented a Wuyi ointment formula suitable for people with qi deficiency constitution.

The present application also invented a preparation method of Wuyi Gao, which is suitable for people with Qi-deficiency constitution, by using Chinese medicine decoction pieces as raw materials. It maintains the decoction characteristics of Wuyi Gao decoction pieces, and making it into traditional ointment is also suitable for long-term conditioning of people with Qi-deficiency constitution. . However, after decoction, the amount of medicinal liquid is large, the decoction time is long, and the concentration period is relatively long. The traditional concentration process uses high temperature concentration, which can produce caramelization reaction and produce flavor substances, but long-term high temperature will degrade the active ingredients. , producing irritating temperatures. In the present invention, it is found through research that controlling the concentration time at about 90°C can achieve a good concentration effect, and concentration at a temperature lower than 70°C takes a long time and increases the cost of making paste.

The present application also invented a preparation method of using traditional Chinese medicine formula granules as raw materials to prepare Wuyi ointment suitable for people with qi deficiency constitution. The preparation time of paste recipes from decoction pieces is significantly shortened. It takes 1 to 2 people to prepare a pot of paste recipes, and the whole process can be completed in 2 hours, which greatly shortens the paste-making time and improves the paste-making efficiency. At the same time, the present invention has found through research that controlling the concentration time at about 90°C can achieve a good concentration effect, and concentration below 70°C takes a long time and increases the cost of making paste.

The preparation method of Wuyi Paste provided by the present invention is prepared from two raw materials of Chinese herbal decoction pieces and traditional Chinese medicine formula granules. Since the raw materials contain more polysaccharides, temperature control is carried out during the concentration process to greatly reduce the caramelization reaction. Improve the quality of the paste and ensure the taste of the paste.

Detailed ways

The implementation of the present invention will be described in detail below in conjunction with specific embodiments.

In the first aspect, the present application provides a Wuyi ointment suitable for people with qi deficiency constitution, which is prepared from the following raw materials in proportions by weight: Polygonatum Polygonatum 120-180 parts, Radix Astragali (burnt) 150-200 parts, Atractylodes macrocephala 150 parts -200 parts, Rehmannia glutinosa 120-180 parts, Lycium barbarum 120-180 parts.

Preferably, Wuyi Paste is prepared from the raw materials in the following proportions by weight: Polygonatum Polygonatum 120-180 parts, Radix Astragali (burnt) 180-200 parts, Atractylodes Rhizoma Atractylodes Rhizome 180-200 parts, Rehmannia glutinosa 120-150 parts, Lycium barbarum 120-200 parts 150 servings.

More preferably, Wuyi ointment is prepared from the raw materials in the following proportions by weight: Polygonatum 150 parts, Radix Astragali (burned) 180 parts, Atractylodes macrocephala 180 parts, Rehmannia glutinosa 150 parts, and Fructus Lycium barbarum 150 parts.

The preparation method of Wuyi ointment suitable for Qi-deficiency constitution as described in any one of the above is as follows:

(1) The preparation method taking Chinese herbal decoction pieces as raw material:

A preparation method of Wuyi ointment suitable for qi-deficiency constitution, the steps include soaking, decocting, concentrating, collecting the ointment, cooling the ointment, and the preparation method includes the following steps:

The first step of weighing: weighing the raw material components in the form of each Chinese herbal decoction piece according to the distribution ratio of the raw material components of Wuyi Gao according to any one of claims 1-3;

The second step of water extraction: put all the raw material components into a clean casserole, copper pot or stainless steel pot with equivalent capacity, and completely immerse the medicinal materials with 6 to 12 times the amount of water (for decocting the head juice for medicinal purposes), soaking time 1 hour; heat and decoct the soaked medicinal materials, first boil at 100°C, and then simmer for about 1 to 2 hours. At this time, the medicinal juice becomes thicker, and the first medicinal juice can be filtered out with gauze or a 24-40 mesh sieve , add 6 times the amount of water to decoct, the decoction method is the same as before, boil with strong fire, and then decoct with slow fire for about 1 hour, this is the second decoction; after filtering the medicinal juice, discard the medicinal residue; Mix, let stand, and then precipitate and filter or filter with a 100-mesh sieve;

Step 3 Concentration: Pour the filtered medicinal juice into a pot for concentration. You can use strong fire first to speed up the evaporation of water, and skim off the foam at any time to make the medicinal juice slowly thicken, and use a slow fire (85 ℃) is further concentrated. At this time, it should be stirred continuously until the medicine juice drips on the paper and does not disperse. At this time, the torment can be suspended. This is the concentrated clear paste, which is concentrated to a relative density of 1.02 -1.05 clear ointment, concentration temperature 70-90°C, weigh the weight of the clear ointment;

The fourth step is to collect the ointment: put the amount of honey into the ointment according to the weight of the ointment: honey weight = 1: 0.4 ~ 0.5, pour it into the ointment, put it on a small fire and simmer slowly, and stir it continuously with a shovel until it is concentrated to the liquid "Fish eye bubbles" can be pulled into flags or dripped into beads (drop the paste into clear water to condense into beads and not disperse);

The fifth step of canning: After the collected paste is cooled, put it into a clean porcelain wide-mouth container, cover the mouth of the container with clean gauze, and let it stand overnight. After it is completely cooled, add Cover and refrigerate.

Further, after the fifth canning step, the preparation method further includes:

The sixth step of quality inspection: conduct quality inspection of Wuyi ointment. Appearance The paste should be fine in texture, suitable in consistency, free from froth, rancidity and mildew.

Further, after the sixth canning step, the preparation method further includes:

The seventh step is labeling: the medicinal liquid is concentrated to collect the ointment, and it can be packaged after it is cooled slightly and there is no water vapor, and the ointment instructions are attached, and the label is attached.

(2) A preparation method using traditional Chinese medicine granules as a raw material.

A preparation method of Wuyi ointment suitable for qi-deficiency constitution, the steps include preheating, dissolving, concentrating, collecting ointment, cooling ointment process, and the preparation method comprises:

The first step of weighing: according to the ratio of raw materials of Wuyi Paste described in any one of claims 1-3, each Chinese medicine raw material granule (converted into particle weight according to the particle standard) is weighed, and each Chinese medicine raw material granule that is cleaned is put into the ointment In the liner of the square machine, fully submerge the medicinal material with 1.5 times the amount of water;

The second step is to set the ointment cooking program: turn on the equipment of the granule ointment square machine, enter the setting interface, set preheating (preheating is required for dissolving in cold water, and no preheating is required for dissolving in hot water), dissolving (dissolving at 70°C for 10 minutes), and concentrating (concentration temperature 80-90°C, time 15-20 minutes), cream collection (temperature 80-90°C, time 10-15 minutes) process flow and time, gear (temperature) and stirring speed of each process, parameter setting Return to the main interface after completion, start operation, automatically heat and stir, start to boil the paste, concentrate to a clear paste with a relative density of 1.02-1.05, the concentration temperature is 70-90°C, and weigh the weight of the clear paste;

The third step of concentration: when starting the cream collection process, pour in honey according to particle weight: honey weight = 1: 0.4-0.5, continue heating and stirring, and run the machine. After the machine is finished, the liquid will form "fish eye bubbles" , can be pulled into flags or dripped into beads (drop the cream juice into clear water to condense into beads and not disperse);

The fourth step is to cool the ointment: after the collected ointment is cooled, put it into a clean porcelain wide-mouth container, cover the container mouth with clean gauze, and let it stand overnight. After it is completely cooled, add Cover and refrigerate.

Further, after the fourth cold paste step, the preparation method also includes:

The fifth step of quality inspection: Appearance The paste should be fine in texture, suitable in consistency, free from floating foam, rancidity and mildew.

Further, after the fifth step of quality inspection, the preparation method further includes:

The sixth step is labeling: the medicinal liquid is concentrated and the ointment is collected, and it can be packaged after it is cooled slightly and there is no water vapor.

The present application also provides an application of the above-mentioned Wuyi ointment in the preparation of medicines for conditioning and improving Qi-deficiency constitution.

Wuyi Ointment cures mainly deficiency and damage. Polygonatum odoratum in the formula is sweet in nature and slightly cold in nature, and it belongs to the lung and stomach meridians, and belongs to yin-tonifying medicine. It has the effects of nourishing yin and moistening dryness, promoting body fluid and quenching thirst. Astragalus membranaceus is sweet in nature and flavor, slightly warm, and belongs to the spleen and lung meridians, and belongs to Qi-tonifying medicine. It has the effects of invigorating qi and promoting yang, benefiting health and strengthening the exterior, diuresis and swelling, and promoting granulation of sores. Sun-roasted Astragalus enhances the effect of invigorating Qi and invigorating the middle. Atractylodes macrocephala is bitter, sweet and warm in nature, belongs to the spleen and stomach meridians, and belongs to Qi-tonifying medicine. It has the effects of invigorating qi and invigorating the spleen, drying dampness and promoting diuresis, solidifying the surface and antiperspirant, and preventing miscarriage. Rehmannia glutinosa is sweet and slightly warm in nature, belongs to the liver and kidney channels, and belongs to blood tonic. It has the effects of nourishing blood and nourishing yin, benefiting essence and filling marrow. Fructus Lycium barbarum nature and flavor are sweet, flat, return liver, kidney meridian. This prescription nourishes qi and nourishes yin, harmonizes yin and yang. In the prescription, Astragalus is used to invigorate the middle and Qi, which is the monarch drug, Atractylodes macrocephala is used to invigorate Qi and strengthen the spleen, and it is used as a minister drug. Polygonatum odoratum, rehmannia glutinosa, and medlar are nourishing yin and blood, and are the source of qi and hair growth, and they are all adjuvant drugs. The five zang-organs correspond to astragalus for nourishing the heart, Atractylodes for nourishing the spleen, Polygonatum for nourishing the lungs and body fluid, Lycium barbarum for nourishing the liver and blood, and Rehmannia glutinosa for nourishing the kidney. The five Tibetans store the essence without letting it out, so it is full but not full. Qi, blood, essence and body fluid are the material basis of the human body. Qi, blood, yin and yang are harmonized, and the human body tends to be peaceful.

A total of 70 patients were selected from the Chinese Medicine Outpatient Department of Shenzhen Guangming District Institute of Traditional Chinese Medicine Inheritance and Development and Shenzhen Hospital (Guangming) of the University of Chinese Academy of Sciences from October 2021 to January 2022, and were divided into experimental groups by random number table method. 35 cases , 35 cases in the control group. During the observation period, 35 cases were completed in the test group, 35 cases were completed in the control group, and 0 cases were dropped out. A clinical observation form was formulated, and the observation records were filled in by special personnel. The observation contents included the classification and judgment form of TCM constitution and the SF-36 quality of life scale.

(1) Efficacy Judgment Criteria In this study, ointment was used to treat people with qi-deficiency constitution, and the degree of qi-deficiency of patients was evaluated by TCM constitution classification and judgment table qi-deficiency body score (transformation score of qi-deficiency constitution evaluation is ≥ 40 points).

The SF-36 quality of life scale includes physiological function, social function, emotion, energy and other aspects. The physical state of qi deficiency is a state between disease and health. It will not affect the personal life, work, and study too much, but it will affect the psychological state to a certain extent, which will affect the quality of life. Therefore, this study uses this scale for evaluation, which can evaluate the quality of life of patients from multiple dimensions.

(2) Statistical methods SPSS20.0 software was used to statistically analyze the collected data. The data of each group are shown as X±s, group t test was used for comparison between groups, paired t test was used for self-comparison before and after, and P<0.05 indicated statistical significance.

(3) Results

1. General Information

The mean ages of the two groups of patients were 40.69 and 36.69 years old respectively; there were 7 male patients and 23 female patients in the treatment group, and 10 male patients and 20 female patients in the control group. There was no significant difference in age and sex between the two groups (P>0.05).

Table 1 Age of patients in the two groups (X±s)

Table 2 Gender of patients in the two groups

2. Score of qi deficiency

There was no significant difference in the scores of qi deficiency constitution between the two groups before enrollment (t=1.576, p=0.120>0.05); after 2 weeks of treatment, there was a statistically significant difference in the scores of qi deficiency between the two groups (t=-3.386, p= 0.001<0.05); after 4 weeks of treatment, there was a statistically significant difference in Qi deficiency scores between the two groups (t=-5.467, p=0.000<0.05), and the improvement in the treatment group was better than that in the control group.

Table 3 Comparison of qi deficiency scores between the two groups of patients (X±s)

3. sf-36 scoring situation

There was no statistically significant difference between the 9 items in the sf-36 score between the two groups before enrollment (p=0.584, 0.486, 0.098, 0.148, 0.128, 0.072, 0.48, 0.727, 0.085>0.05); after 2 weeks of treatment There were statistically significant differences in physiological function and qi deficiency scores between the latter two groups (t=-3.386, p=0.001<0.05); after 2 weeks of treatment, there was statistically significant difference in physiological function between the two groups (t =4.561, p=0.000<0.05), the improvement of the treatment group was better than that of the control group; after 4 weeks of treatment, there were statistically significant differences in the three items of physiological function, physiological function and energy between the two groups (t=4.817, 3.222, 3.360, p=0.000, 0.002, 0.001<0.05), the improvement in the treatment group was better than that in the control group.

Table 4.1 Comparison of sf-36 baseline scores between the two groups of patients (X±s)

Table 4.1 Comparison of sf-36 scores in the two groups of patients for two weeks (X±s)

Table 4.1 Comparison of sf-36 scores in the two groups of patients at four weeks (X±s)

4. The safety and adverse reactions of patients in the two groups were followed up for 1 month after administration of the subjects, and there were no obvious adverse reactions. The test group had no adverse reactions during bone-setting administration. One case of diarrhea in the control group did not stop the drug, and the symptoms disappeared after 2 days. After analysis, it had nothing to do with the test substance and was an adverse event.

(4) Conclusion and discussion

Physical fitness score is an important content for judging physical fitness, among which Wuyi Ointment has a significant effect on improving the qi-deficiency constitution score of patients with qi-deficiency constitution. In the sf-36 scoring table, Wuyi Ointment has significantly improved the physiological function, physiological function, and energy items. Among them, the physiological function item has been significantly improved after 2 weeks of medication. The physiological function, physiological function, and energy items in the sf-36 scoring table The three items of physiological function and energy are consistent with the improvement of qi-deficiency constitution scores, and there may be a certain correlation between the three scores and qi-deficiency constitution scores, which needs to be confirmed in the future.

This study shows that after taking Wuyi ointment, it is confirmed that Wuyi ointment can significantly improve Qi deficiency constitution. This project provides a new possible conditioning program, and clarifies the impact of Wuyi ointment on the quality of life of people with qi deficiency constitution. Through the conditioning of Wuyi ointment, the quality of life of people with qi deficiency constitution can be improved. By macroscopically observing and analyzing the clinical curative effect of Wuyi ointment before and after regulating Qi-deficiency constitution, it provides clinical data for Wuyi ointment to prevent and treat Qi-deficiency constitution, so as to promote its clinical application. This project has great reference significance for the research and development of classic prescriptions of traditional Chinese medicine, and has high promotion value and clinical application prospect. It is expected to receive high economic and social benefits.

According to the theory of "preventive treatment of disease" in traditional Chinese medicine, the present application has invented a Wuyi ointment prescription suitable for people with qi deficiency constitution.

The present application also invented a preparation method of Wuyi Gao, which is suitable for people with Qi-deficiency constitution, by using Chinese medicine decoction pieces as raw materials. It maintains the decoction characteristics of Wuyi Gao decoction pieces, and making it into traditional ointment is also suitable for long-term conditioning of people with Qi-deficiency constitution. . However, after decoction, the amount of medicinal liquid is large, the decoction time is long, and the concentration period is relatively long. The traditional concentration process uses high temperature concentration, which can produce caramelization reaction and produce flavor substances, but long-term high temperature will degrade the active ingredients. , producing irritating temperatures. In the present invention, it is found through research that controlling the concentration time at about 90°C can achieve a good concentration effect, and concentration at a temperature lower than 70°C takes a long time and increases the cost of making paste.

The present application also invented a preparation method of using traditional Chinese medicine formula granules as raw materials to prepare Wuyi ointment suitable for people with qi deficiency constitution. The preparation time of paste recipes from decoction pieces is significantly shortened. It takes 1 to 2 people to prepare a pot of paste recipes, and the whole process can be completed in 2 hours, which greatly shortens the paste-making time and improves the paste-making efficiency. At the same time, the present invention has found through research that controlling the concentration time at about 90°C can achieve a good concentration effect, and concentration below 70°C takes a long time and increases the cost of making paste.

The preparation method of Wuyi Paste provided by the present invention is prepared from two raw materials of Chinese herbal decoction pieces and traditional Chinese medicine formula granules. Since the raw materials contain more polysaccharides, temperature control is carried out during the concentration process to greatly reduce the caramelization reaction. Improve the quality of the paste and ensure the taste of the paste.

In the description of this specification, descriptions referring to the terms "one embodiment", "some embodiments", "example", "specific examples", or "some examples" mean that specific features described in connection with the embodiment or example , structure, material or feature is included in at least one embodiment or example of the present invention. In this specification, the schematic representations of the above terms are not necessarily directed to the same embodiment or example. Furthermore, the described specific features, structures, materials or characteristics may be combined in any suitable manner in any one or more embodiments or examples. In addition, those skilled in the art can combine and combine different embodiments or examples and features of different embodiments or examples described in this specification without conflicting with each other.

Although the embodiments of the present invention have been shown and described above, it can be understood that the above embodiments are exemplary and should not be construed as limiting the present invention, and those skilled in the art can make the above-mentioned The embodiments are subject to changes, modifications, substitutions and variations.

Claims (10)

1. The Wuyi paste is characterized by being prepared from the following raw material medicines in parts by weight: 120-180 parts of fragrant solomonseal rhizome, 150-200 parts of astragalus (roasted), 150-200 parts of largehead atractylodes rhizome, 120-180 parts of prepared rhizome of rehmannia and 120-180 parts of barbary wolfberry fruit.

2. The five-component beneficial paste for people with qi-deficiency constitution according to claim 1, which is prepared from the following raw material medicines in parts by weight: 120-180 parts of polygonatum odoratum, 180-200 parts of astragalus (roasted), 180-200 parts of bighead atractylodes rhizome, 120-150 parts of prepared rhizome of rehmannia and 120-150 parts of wolfberry fruit.

3. The five-component beneficial paste for people with qi-deficiency constitution according to claim 2, wherein the five-component beneficial paste is prepared from the following raw material medicines in parts by weight: 150 parts of polygonatum odoratum, 180 parts of astragalus root (roasted), 180 parts of bighead atractylodes rhizome, 150 parts of prepared rhizome of rehmannia and 150 parts of wolfberry fruit.

4. A preparation method of Wuyi paste suitable for qi deficiency constitution is characterized by comprising the following steps of soaking, decocting, concentrating, collecting paste and cooling the paste, and the preparation method comprises the following steps:

first-step weighing: weighing the raw material components in the form of the traditional Chinese medicine decoction pieces according to the raw material component proportion of the five-component beneficial paste of any one of claims 1 to 3;

the second step of water extraction: putting all the raw material components into a clean earthen pot, a copper pot or a stainless steel pot with the same volume, and completely immersing and soaking the medicinal materials (for decocting the first decoction) by 6-12 times of water for 1 hour; heating and decocting the soaked medicinal materials, boiling at 100 ℃, then boiling for about 1-2 hours with slow fire, then gradually concentrating the medicinal liquid, filtering out the first medicinal liquid with gauze or a 24-40 mesh sieve, adding 6 times of water for decocting, boiling with strong fire before the same decocting method, and then decocting for about 1 hour with slow fire, thus obtaining second decoction; filtering out the medicinal liquid, and removing the medicinal residue; mixing the decoctions, standing, and precipitating or filtering with 100 mesh sieve;

and a third step of concentration: pouring the filtered medicine juice into a pot, concentrating, wherein strong fire can be used for accelerating water evaporation, floating foam is skimmed at any time, the medicine juice slowly becomes thick, slow fire (85 ℃) is used for further concentration, stirring is continuously carried out at the moment until the medicine juice is not scattered on paper, decocting can be suspended at the moment, the medicine juice is the concentrated clear paste, the concentrated clear paste is concentrated to the relative density of 1.02-1.05, the concentration temperature is 70-90 ℃, and the weight of the clear paste is weighed;

the fourth step of paste collection: mixing the following materials in percentage by weight of honey: honey weight =1:0.4 to 0.5 of the paste is poured into the clear paste, the clear paste is slowly boiled over small fire and is continuously stirred by a shovel, and the paste is concentrated until the liquid medicine is soaked in fish eyes and can be pulled into a flag or dripped into beads (the paste is dripped into clear water to be condensed into beads without scattering);

and fifthly, canning: cooling the collected paste, placing into a clean porcelain wide-mouth container, covering the container with clean gauze, standing overnight, cooling completely, covering, and refrigerating in refrigerator.

5. The method for preparing Wuyi paste for qi-deficiency constitution according to claim 4, wherein after the fifth canning step, the method further comprises:

sixth step, quality inspection: and (5) performing quality inspection on the five beneficial pastes. The appearance paste has the advantages of fine texture, proper consistency, no floating foam, no rancidity and no mildew.

6. The method for preparing Wuyi paste according to claim 5, wherein after the sixth canning step, the method further comprises:

step seven, labeling: concentrating the medicinal liquid to obtain paste, cooling slightly, removing water vapor, packaging, adding paste administration instruction, and labeling.

7. A preparation method of Wuyi paste suitable for qi-deficiency constitution is characterized by comprising the following steps of preheating, dissolving, concentrating, paste collecting and paste cooling, and the preparation method comprises the following steps:

first-step weighing: weighing the traditional Chinese medicine raw material particles (the weight of the particles is converted according to the particle standard) according to the raw material proportion of the Wuyi plaster of any one of claims 1 to 3, putting the clean traditional Chinese medicine raw material particles into an inner container of a plaster formula machine, and completely immersing the medicine materials by using 1.5 times of water;

and the second step of setting the paste boiling program: opening the particle paste machine equipment, entering a set interface, setting preheating (cold water dissolution needs preheating, hot water dissolution does not need preheating), dissolution (70 ℃ dissolution, 10 minutes), concentration (concentration temperature is 80-90 ℃, time is 15-20 minutes), paste collection (temperature is 80-90 ℃, time is 10-15 minutes), process flow, time, gear (temperature) and stirring revolution of each process, returning to a main interface after parameter setting is finished, starting operation, automatically heating and stirring, starting paste boiling, concentrating to obtain clear paste with relative density of 1.02-1.05, and weighing the weight of the clear paste at concentration temperature of 70-90 ℃;

and a third step of concentration: when the paste collecting process is started, the weight of the particles is as follows: honey weight =1:0.4 to 0.5 of honey is poured in, the heating and the stirring are continued, the machine is operated, after the standby device is operated, the liquid medicine is soaked in fish eyes, and can be pulled to form a flag or be dripped to form beads (the paste is dripped into clear water to be condensed into beads without dispersion);

fourthly, cooling the paste: cooling, loading into clean wide-mouth container, covering with clean gauze, standing overnight, cooling, covering, and refrigerating.

8. The method for preparing Wuyi paste according to claim 7, wherein after the fourth step of paste cooling, the method further comprises:

fifth step, quality inspection: the appearance paste has the advantages of fine texture, proper consistency, no floating foam, no rancidity and no mildew.

9. The method for preparing Wuyi paste for qi-deficiency constitution according to claim 8, wherein after the fifth step of quality inspection, the method further comprises:

sixth step labeling: concentrating the medicinal liquid to obtain paste, cooling slightly, removing water vapor, packaging, adding paste administration instruction, and labeling.

10. Use of the Wuyi paste of any one of claims 1-3 in the preparation of a medicament for conditioning and improving qi-deficiency constitution.