CN115252717A - Wuyi paste suitable for people with qi deficiency constitution, preparation method and application thereof - Google Patents

Wuyi paste suitable for people with qi deficiency constitution, preparation method and application thereof Download PDF

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CN115252717A
CN115252717A CN202211076431.7A CN202211076431A CN115252717A CN 115252717 A CN115252717 A CN 115252717A CN 202211076431 A CN202211076431 A CN 202211076431A CN 115252717 A CN115252717 A CN 115252717A
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paste
parts
wuyi
preparation
cooling
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谭淑仪
曾林燕
闫光耀
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract

The invention relates to the technical field of paste formulas, and discloses a five-component beneficial paste suitable for people with qi-deficiency constitution, a preparation method and application thereof, wherein the five-component beneficial paste suitable for people with qi-deficiency constitution is characterized by being prepared from the following raw material medicines in parts by weight: 120-180 parts of polygonatum odoratum, 150-200 parts of astragalus (roasted), 150-200 parts of bighead atractylodes rhizome, 120-180 parts of prepared rhizome of rehmannia and 120-180 parts of wolfberry fruit; according to the Wuyi paste and the preparation method thereof, the Wuyi paste is prepared from two raw materials of traditional Chinese medicine decoction pieces and traditional Chinese medicine formula granules, and because the raw materials contain more polysaccharide substances, the temperature is controlled in the concentration process, the caramelization reaction is greatly reduced, the quality of the paste is improved, and the taste of the paste is ensured.

Description

Wuyi paste suitable for people with qi deficiency constitution, preparation method and application thereof
Technical Field
The invention relates to the technical field of paste formulas, in particular to a five-component beneficial paste suitable for people with qi deficiency constitution, a preparation method and application thereof.
Background
The herbal formulation of ointment (also known as soft extract or decocted extract) is one of the eight common dosage forms of Chinese herbs, and it originated in the war of spring and autumn in the first book of Huangdi's classic, the Chinese herbal extracts and horse extracts were recorded. With the rise of living standard and the enhancement of health preserving consciousness, the thought of Chinese medicine for treating the disease is deep into the mind.
At present, the prevention and health care system can not well meet the requirements of people, and the traditional Chinese medicine treatment is increasingly important. The traditional Chinese medicine ointment formula developed under the guidance of the theory of preventing diseases in the traditional Chinese medicine has the characteristics of multiple target spots, low drug effect, mild drug efficacy, stability and durability, and achieves the effects of reinforcing the primordial qi, strengthening the foundation, rectifying deviation, removing diseases, resisting aging and prolonging life through the action of continuously and slowly adjusting the balance of yin and yang in a drip irrigation mode. The development research and the practical exploration of the traditional Chinese medicine plaster are strengthened, the theoretical achievement of the traditional Chinese medicine plaster is enriched and perfected, the clinical application of the traditional Chinese medicine plaster is promoted, and the traditional Chinese medicine culture is inherited and carried forward. The traditional Chinese medicine paste formula theory has increasingly increased practical achievements, continuously expands the clinical application range and presents obvious special characteristics, but the research on the people with the abnormal constitution conditioned by the paste formula established by the traditional Chinese medicine classic formula is relatively rare, and a five-benefit paste suitable for people with qi-deficiency constitution is lacked.
Disclosure of Invention
The invention aims to invent the five-beneficial paste which is suitable for people with qi-deficiency constitution to take according to the theory of 'preventive treatment of disease' in traditional Chinese medicine;
the invention further aims to provide a preparation method of the five-component beneficial paste suitable for people with qi-deficiency constitution;
the invention further aims to provide application of the five-component beneficial paste suitable for people with qi-deficiency constitution.
In order to realize the first purpose, the invention adopts the technical scheme that:
the Wuyi paste is prepared from the following raw material medicines in parts by weight: 120-180 parts of polygonatum odoratum, 150-200 parts of astragalus (roasted), 150-200 parts of bighead atractylodes rhizome, 120-180 parts of prepared rhizome of rehmannia and 120-180 parts of wolfberry fruit.
Preferably, the Wuyi paste is prepared from the following raw material medicines in parts by weight: 120-180 parts of polygonatum odoratum, 180-200 parts of astragalus (roasted), 180-200 parts of bighead atractylodes rhizome, 120-150 parts of prepared rhizome of rehmannia and 120-150 parts of wolfberry fruit.
Preferably, the Wuyi ointment is prepared from the following raw material medicines in parts by weight: 150 parts of polygonatum odoratum, 180 parts of astragalus root (roasted), 180 parts of bighead atractylodes rhizome, 150 parts of prepared rhizome of rehmannia and 150 parts of wolfberry fruit.
In order to achieve the second purpose, the invention adopts the technical scheme that:
the preparation method of the five-component beneficial paste suitable for qi-deficiency constitution comprises the following steps:
a preparation method taking traditional Chinese medicine decoction pieces as raw materials.
A preparation method of Wuyi paste suitable for qi deficiency constitution comprises the steps of soaking, decocting, concentrating, collecting paste and cooling the paste, and the preparation method comprises the following steps:
first-step weighing: weighing the raw material components in the form of the traditional Chinese medicine decoction pieces according to the raw material component proportion of the five-component beneficial paste of any one of claims 1 to 3;
the second step of water extraction: putting all the raw material components into a clean earthen pot, a copper pot or a stainless steel pot with the same volume, and completely immersing and soaking the medicinal materials (for decocting the first decoction) by 6-12 times of water for 1 hour; heating and decocting the soaked medicinal materials, boiling at 100 ℃, then boiling for about 1-2 hours with slow fire, then gradually concentrating the medicinal liquid, filtering out the first medicinal liquid with gauze or a 24-40 mesh sieve, adding 6 times of water for decocting, boiling with strong fire before the same decocting method, and then decocting for about 1 hour with slow fire, thus obtaining second decoction; filtering out the medicinal liquid, and removing the medicinal residue; mixing the decoctions, standing, and precipitating or filtering with 100 mesh sieve;
and a third step of concentration: pouring the filtered medicine juice into a pot, concentrating, wherein strong fire can be used for accelerating water evaporation, floating foam is skimmed at any time, the medicine juice slowly becomes thick, slow fire (85 ℃) is used for further concentration, stirring is continuously carried out at the moment until the medicine juice is not scattered on paper, decocting can be suspended at the moment, the medicine juice is the concentrated clear paste, the concentrated clear paste is concentrated to the relative density of 1.02-1.05, the concentration temperature is 70-90 ℃, and the weight of the clear paste is weighed;
fourthly, paste collection: mixing the following materials in percentage by weight of honey: honey weight =1:0.4 to 0.5 of the paste is poured into the clear paste, the clear paste is slowly boiled over small fire and is continuously stirred by a shovel, and the paste is concentrated until the liquid medicine is soaked in fish eyes and can be pulled into a flag or dripped into beads (the paste is dripped into clear water to be condensed into beads without scattering);
and fifthly, canning: cooling the collected paste, placing into a clean porcelain wide-mouth container, covering the container with clean gauze, standing overnight, cooling completely, covering, and refrigerating in refrigerator.
Further, after the fifth canning step, the preparation method further comprises:
sixth step quality inspection: and (5) performing quality inspection on the five beneficial pastes. The appearance paste has the advantages of fine texture, proper consistency, no floating foam, no rancidity and no mildew.
Further, after the sixth canning step, the preparation method further comprises:
seventh step labeling: concentrating the medicinal liquid, collecting paste, cooling to a certain temperature, packaging, adding paste, and labeling.
(II) a preparation method taking traditional Chinese medicine granules as raw materials.
A preparation method of Wuyi paste suitable for qi deficiency constitution comprises the steps of preheating, dissolving, concentrating, paste collecting and paste cooling, and the preparation method comprises the following steps:
first-step weighing: weighing the traditional Chinese medicine raw material particles (the weight of the particles is converted according to the particle standard) according to the raw material proportion of the Wuyi plaster of any one of claims 1 to 3, putting the clean traditional Chinese medicine raw material particles into an inner container of a plaster formula machine, and completely immersing the medicine materials by using 1.5 times of water;
setting a paste boiling program in the second step: opening the particle paste machine equipment, entering a set interface, setting preheating (cold water dissolution needs preheating, hot water dissolution does not need preheating), dissolution (70 ℃ dissolution, 10 minutes), concentration (concentration temperature is 80-90 ℃, time is 15-20 minutes), paste collection (temperature is 80-90 ℃, time is 10-15 minutes), process flow, time, gear (temperature) and stirring revolution of each process, returning to a main interface after parameter setting is finished, starting operation, automatically heating and stirring, starting paste boiling, concentrating to obtain clear paste with relative density of 1.02-1.05, and weighing the weight of the clear paste at concentration temperature of 70-90 ℃;
and a third step of concentration: when the paste collecting process is started, the weight of the particles is as follows: honey weight =1:0.4 to 0.5 of honey is poured in, the heating and the stirring are continued, the machine is operated, after the operation of the standby device is finished, the liquid medicine is stirred into 'fisheye bubbles', and can be pulled into a flag or dripped into beads (the paste is dripped into clear water to be condensed into beads without scattering);
fourthly, cooling the paste: cooling the collected paste, placing into a clean porcelain wide-mouth container, covering the container with clean gauze, standing overnight, cooling completely, covering, and refrigerating in refrigerator.
Further, after the fourth step of paste cooling, the preparation method further comprises:
fifth step quality inspection: the external cream has fine texture, proper consistency, no floating foam, no rancidity and no mildew.
Further, after the fifth quality inspection step, the preparation method further comprises:
sixthly, labeling: concentrating the medicinal liquid to obtain paste, cooling slightly, removing water vapor, packaging, adding paste administration instruction, and labeling.
The application also provides an application of the five-component beneficial paste in preparing a medicine for conditioning and improving qi-deficiency constitution.
The invention has the beneficial effects that: the application invents a five-beneficial ointment formula suitable for people with qi-deficiency constitution to take according to the theory of 'preventive treatment of disease' in traditional Chinese medicine.
The application also discloses a preparation method of the Wuyi paste which is prepared from the traditional Chinese medicine decoction pieces serving as raw materials and is suitable for people with qi-deficiency constitution, the decocting characteristic of the Wuyi paste decoction pieces is kept, and the Wuyi paste is prepared into a traditional paste which is also suitable for long-term conditioning of people with qi-deficiency constitution. However, the decoction has the disadvantages of large amount of liquid medicine after decoction, long decoction time and long concentration time period, and the traditional concentration process adopts high-temperature concentration, wherein caramelization reaction can be generated at high temperature to generate flavor substances, but the effective components can be degraded at high temperature for a long time to generate irritant temperature. According to the invention, researches show that the concentration time is controlled to be about 90 ℃, so that a good concentration effect can be achieved, the concentration time is long when the concentration time is lower than 70 ℃, and the paste preparation cost is increased.
Compared with the traditional Chinese medicine decoction pieces for preparing the paste formula, the paste formula prepared by the paste formula machine has the advantages that the preparation time is obviously shortened, 1 to 2 persons are required for preparing one pot of the paste formula, the whole process can be completed within 2 hours, the paste preparation time is greatly shortened, and the paste preparation efficiency is improved. Meanwhile, the research shows that the concentration time is controlled to be about 90 ℃, the good concentration effect can be achieved, the time consumption for concentration is long when the temperature is lower than 70 ℃, and the paste preparation cost is increased.
The preparation method of the Wuyi paste provided by the invention is characterized in that the Wuyi paste is prepared from two raw materials of traditional Chinese medicine decoction pieces and traditional Chinese medicine formula granules, and because the raw materials contain more polysaccharide substances, the temperature is controlled in the concentration process, the caramelization reaction is greatly reduced, the quality of the paste is improved, and the taste of the paste is ensured.
Detailed Description
The following describes the implementation of the present invention in detail with reference to specific embodiments.
In a first aspect, the application provides a five-component beneficial paste suitable for people with qi-deficiency constitution, which is prepared from the following raw material medicines in parts by weight: 120-180 parts of fragrant solomonseal rhizome, 150-200 parts of astragalus (roasted), 150-200 parts of largehead atractylodes rhizome, 120-180 parts of prepared rhizome of rehmannia and 120-180 parts of barbary wolfberry fruit.
Preferably, the Wuyi ointment is prepared from the following raw material medicines in parts by weight: 120-180 parts of fragrant solomonseal rhizome, 180-200 parts of astragalus (roasted), 180-200 parts of largehead atractylodes rhizome, 120-150 parts of prepared rhizome of rehmannia and 120-150 parts of barbary wolfberry fruit.
Preferably, the Wuyi paste is prepared from the following raw material medicines in parts by weight: 150 parts of fragrant solomonseal rhizome, 180 parts of astragalus (roasted), 180 parts of largehead atractylodes rhizome, 150 parts of prepared rhizome of rehmannia and 150 parts of barbary wolfberry fruit.
The preparation method of the five-component beneficial paste suitable for qi-deficiency constitution comprises the following steps:
the preparation method of taking the traditional Chinese medicine decoction pieces as raw materials comprises the following steps:
a preparation method of Wuyi paste suitable for qi deficiency constitution comprises the steps of soaking, decocting, concentrating, collecting paste and cooling the paste, and the preparation method comprises the following steps:
first-step weighing: weighing the raw material components in the form of the Chinese medicinal decoction pieces according to the raw material component proportion of the Wuyi paste of any one of claims 1 to 3;
the second step of water extraction: putting all the raw material components into a clean earthen pot, a copper pot or a stainless steel pot with the same volume, and completely immersing and soaking the medicinal materials (for decocting the first decoction) by using 6-12 times of water for 1 hour; heating and decocting the soaked medicinal materials, boiling at 100 ℃, then boiling with slow fire for about 1-2 hours, then gradually concentrating the medicinal liquid, filtering the first medicinal liquid with gauze or a 24-40 mesh sieve, adding 6 times of water for decocting, boiling with strong fire before the same decocting method, and then decocting with slow fire for about 1 hour, thus obtaining second decoction; filtering out the medicinal liquid, and removing the medicinal residue; mixing the decoctions, standing, and precipitating or filtering with 100 mesh sieve;
and a third step of concentration: pouring the filtered medicinal liquid into a pot, concentrating, wherein strong fire can be used for accelerating water evaporation, floating foam is skimmed at any time, the medicinal liquid slowly becomes thick, and slow fire (85 ℃) is used for further concentrating, stirring is continuously carried out at the moment until the medicinal liquid is not scattered on paper, decocting can be suspended at the moment, the concentrated medicinal liquid is the clear paste, the clear paste is concentrated to the relative density of 1.02-1.05, the concentration temperature is 70-90 ℃, and the weight of the clear paste is weighed;
fourthly, paste collection: mixing the following materials in percentage by weight of honey: honey weight =1:0.4 to 0.5 of the paste is poured into the clear paste, the clear paste is slowly boiled over a small fire and is continuously stirred by a shovel, and the clear paste is concentrated until the liquid medicine becomes 'fisheye bubble', and the liquid medicine can be pulled to form a flag or be dripped to form beads (the paste is dripped into clear water to be condensed into beads without dispersion);
and fifthly, canning: cooling the collected paste, placing into a clean porcelain wide-mouth container, covering the container with clean gauze, standing overnight, cooling completely, covering, and refrigerating in refrigerator.
Further, after the fifth canning step, the preparation method further comprises the following steps:
sixth step, quality inspection: and (5) performing quality inspection on the five beneficial pastes. The appearance paste has the advantages of fine texture, proper consistency, no floating foam, no rancidity and no mildew.
Further, after the sixth canning step, the preparation method further comprises:
seventh step labeling: concentrating the medicinal liquid, collecting paste, cooling to a certain temperature, packaging, adding paste, and labeling.
(II) a preparation method taking traditional Chinese medicine particles as raw materials.
A preparation method of Wuyi paste suitable for qi deficiency constitution comprises the steps of preheating, dissolving, concentrating, paste collecting and paste cooling, and the preparation method comprises the following steps:
first-step weighing: weighing the traditional Chinese medicine raw material particles (the weight of the particles is calculated according to the particle standard) according to the raw material proportion of the Wuyi paste of any one of claims 1-3, putting the clean traditional Chinese medicine raw material particles into an inner container of a paste preparation machine, and completely immersing the medicine materials by 1.5 times of water;
setting a paste boiling program in the second step: opening the granule paste machine equipment, entering a setting interface, setting preheating (cold water dissolution requires preheating, hot water dissolution does not require preheating), dissolution (70 ℃ dissolution, 10 minutes), concentration (concentration temperature is 80-90 ℃, time is 15-20 minutes), paste collection (temperature is 80-90 ℃, time is 10-15 minutes), technological processes, time, gear (temperature) and stirring revolution of each technology, returning to a main interface after parameter setting is finished, starting operation, automatically heating and stirring, starting paste boiling, concentrating to obtain clear paste with relative density of 1.02-1.05, concentrating at the temperature of 70-90 ℃, and weighing the weight of the clear paste;
and a third step of concentration: when the paste collecting process is started, according to the weight of particles: honey weight =1:0.4 to 0.5 of honey is poured in, the heating and the stirring are continued, the machine is operated, after the standby device is operated, the liquid medicine is soaked in fish eyes, and can be pulled to form a flag or be dripped to form beads (the paste is dripped into clear water to be condensed into beads without dispersion);
fourthly, cooling the paste: cooling the collected paste, placing into a clean porcelain wide-mouth container, covering the container with clean gauze, standing overnight, cooling completely, covering, and refrigerating in refrigerator.
Further, after the fourth step of paste cooling, the preparation method further comprises:
fifth step, quality inspection: the appearance paste has the advantages of fine texture, proper consistency, no floating foam, no rancidity and no mildew.
Further, after the fifth step of quality inspection, the preparation method further comprises:
sixth step labeling: concentrating the medicinal liquid to obtain paste, cooling slightly, removing water vapor, packaging, adding paste administration instruction, and labeling.
The application also provides an application of the five-component beneficial paste in preparing a medicine for conditioning and improving qi-deficiency constitution.
Wuyi ointment is used mainly for treating deficiency of the liver and kidney. In the formula, the polygonatum odoratum is sweet in nature and slightly cold in flavor, enters lung and stomach meridians and belongs to yin tonifying medicines. Has the effects of nourishing yin, moistening dryness, promoting the production of body fluid and quenching thirst. Astragalus root, radix astragali, sweet in nature and slightly warm in taste, enters spleen and lung meridians, and belongs to qi tonics. Has the effects of invigorating qi, invigorating yang, invigorating defensive system, consolidating superficial resistance, inducing diuresis, relieving swelling, healing sore, and promoting granulation. Radix astragali Preparata has effects of invigorating qi and strengthening middle warmer. Bighead atractylodes rhizome, bitter in taste, sweet and warm in nature, enters spleen and stomach meridians and belongs to qi-tonifying herbs. Has the effects of tonifying qi and strengthening spleen, eliminating dampness and promoting diuresis, consolidating superficial resistance and arresting sweating, and preventing miscarriage. Prepared rehmannia root, radix rehmanniae Praeparata is sweet in nature and slightly warm in taste, enters liver and kidney meridians and belongs to the blood tonifying medicine. Has the effects of enriching blood, nourishing yin, replenishing vital essence and replenishing marrow. Gou Qi Zi is sweet in nature and neutral in flavor, and enters liver and kidney meridians. The recipe has the effects of tonifying qi, nourishing yin and harmonizing yin and yang. In the formula, the astragalus root is used for strengthening the middle-jiao and replenishing qi and is a monarch drug, the bighead atractylodes rhizome is used for tonifying qi and strengthening the spleen and is a ministerial drug, and the polygonatum, the prepared rhizome of rehmannia and the medlar are used as sources of qi activity and hair growth, and are used as adjuvant drugs together. Five zang organs correspond to qi of heart and qi of astragalus, spleen and qi of atractylodes, lung and fluid of polygonatum, liver and blood of lycium barbarum, kidney essence of rehmannia and kidney essence of rehmannia. Five zang cases store essence but not discharge, so they are full and cannot be excessive. Qi, blood, essence and body fluids are the material basis of human body. Harmonize qi, blood, yin and yang, and make the body constitution mild.
70 patients in 10-2022-2021 are selected to be treated in Shenzhen Hospital (Guangming) of Shenzhen university, shenzhen department of traditional Chinese medicine inheritance and development, and Shenzhen Hospital (Guangming) of Shenzhen university, and are divided into 35 cases in a test group and 35 cases in a control group by a random digital representation. The test group completed 35 cases, the control group completed 35 cases, and the exfoliated case 0 cases during the observation period. And (4) formulating a clinical observation table, and filling observation records by a specially-assigned person, wherein the observation contents comprise a traditional Chinese medicine constitution classification and judgment table and an SF-36 quality of life scale.
The research adopts the ointment formula to condition people with qi-deficiency constitution, and adopts traditional Chinese medicine constitution classification and judgment surface qi-deficiency body score to evaluate the qi-deficiency degree of patients (the qi-deficiency constitution judgment conversion score is more than or equal to 40 points).
The SF-36 quality of life scale includes the contents of physiological functions, social functions, emotional feeling, energy and the like. The qi-deficiency constitution state is a state between diseases and health, does not influence life, work and study of individual policy too much, but influences psychological state to a certain extent, thereby influencing life quality. The study was therefore evaluated using this scale, which allows the quality of life of patients to be assessed from multiple dimensions.
And (II) statistically analyzing the collected data by using SPSS20.0 software. Each group of data is shown as X +/-s, group t test is adopted for comparison among groups, paired t test is adopted for comparison before and after the group, and P is less than 0.05, so that the statistical significance is achieved.
(III) results
1. General data
The mean ages of the two groups of patients were 40.69 years old and 36.69 years old, respectively; treatment groups 7 male patients, 23 female patients, 10 male patients, 20 female patients. The age and sex comparison differences of the two groups of patients have no statistical significance (P is more than 0.05).
TABLE 1 age conditions of two groups of patients (X + -s)
Figure BDA0003831669980000091
TABLE 2 sex profiles of two groups of patients
Figure BDA0003831669980000101
2. Score condition of qi deficiency
Before the two groups of patients are in the group, the difference of the qi-deficiency constitution scores is not statistically significant (t =1.576, p =0.120 > 0.05); the difference between the scores of vital qi deficiency in the two groups of patients after 2 weeks of treatment was statistically significant (t = -3.386, p = -0.001 < 0.05); the difference of the qi deficiency scores of the two groups of patients after 4 weeks of treatment is statistically significant (t = -5.467, p =0.000 < 0.05), and the improvement of the treatment group is better than that of the control group.
TABLE 3 score comparison of vital energy deficiency of two groups of patients (X + -s)
Figure BDA0003831669980000102
Sf-36 score
No statistical difference between 9 of the subjects in the sf-36 score before the two groups were enrolled (p =0.584, 0.486, 0.098, 0.148, 0.128, 0.072, 0.48, 0.727, 0.085 > 0.05); after 2 weeks of treatment, the difference between the physiological function and the qi deficiency scores of the two groups of patients is statistically significant (t = -3.386, p = -0.001 < 0.05); after 2 weeks of treatment, the difference between the two groups of patients in the physiological function is statistically significant (t =4.561, p =0.000 < 0.05), and the improvement of the treatment group is better than that of the control group; after 4 weeks of treatment, the comparison difference between the physiological function, physiological function and energy of the two groups of patients has statistical significance (t =4.817, 3.222, 3.360,p =0.000, 0.002, 0.001 < 0.05), and the improvement of the treatment group is better than that of the control group.
TABLE 4.1 comparison of sf-36 baseline scores (X. + -. S) for two groups of patients
Figure BDA0003831669980000103
Figure BDA0003831669980000111
TABLE 4.1 two groups of patients comparison of two week sf-36 scores (X. + -.s)
Figure BDA0003831669980000112
TABLE 4.1 comparison of sf-36 score in four groups of patients (X. + -.s)
Figure BDA0003831669980000113
Figure BDA0003831669980000121
4. The safety and adverse reaction of two groups of patients are subjected to safety tracking on the condition that the drug administration of the test subject is carried out for 1 month, and no obvious adverse reaction occurs. The test group has no adverse reaction in the bone setting administration process. The control group showed 1 case of diarrhea, no withdrawal, and the symptoms eliminated by itself after 2 days, and was analyzed to be independent of the test substance and to be an adverse event.
(IV) conclusion and discussion
The constitution score is used as an important content for judging the constitution, wherein the five-benefit paste has an obvious effect on improving the qi-deficiency constitution score of patients with qi deficiency, and after 1 month of treatment, the qi-deficiency constitution score of the patients is obviously reduced, and the living state of the patients is obviously improved; in the sf-36 scoring table, the five-benefit ointment has more remarkable improvement on physiological functions, physiological functions and energy items, wherein one physiological function is obviously improved after the five-benefit ointment is taken for 2 weeks, the physiological functions, physiological functions and energy items in the sf-36 scoring table are consistent with the improvement on qi deficiency constitution scores, and the three scores possibly have certain relevance with the qi deficiency constitution scores and are to be verified subsequently.
The study shows that after the five-component benefiting paste is taken, the five-component benefiting paste is proved to be capable of obviously improving the constitution of qi deficiency. The project provides a new possible conditioning scheme, and the influence of the five-component beneficial paste on the life quality of people with qi-deficiency constitution is determined. The life quality of people with qi deficiency constitution is improved by conditioning the five-component beneficial paste. By observing and analyzing the clinical effects of the five-benefit ointment on people with qi-deficiency constitution, the five-benefit ointment provides clinical data for preventing and treating qi-deficiency constitution, so that the five-benefit ointment is convenient to popularize and apply clinically. The project has great reference significance for the research and development of the traditional Chinese medicine classic formula, higher popularization value and clinical application prospect, and is expected to receive higher economic benefit and social benefit.
The application invents a five-benefit paste formula suitable for people with qi-deficiency constitution according to the theory of 'preventive treatment of disease' in traditional Chinese medicine.
The application also discloses a preparation method of the Wuyi paste which is prepared from the traditional Chinese medicine decoction pieces serving as raw materials and is suitable for people with qi-deficiency constitution, the decocting characteristic of the Wuyi paste decoction pieces is kept, and the Wuyi paste is prepared into a traditional paste which is also suitable for long-term conditioning of people with qi-deficiency constitution. However, the decoction has the disadvantages of large amount of liquid medicine after decoction, long decoction time and long concentration time period, and the traditional concentration process adopts high-temperature concentration, wherein caramelization reaction can be generated at high temperature to generate flavor substances, but the effective components can be degraded at high temperature for a long time to generate irritant temperature. According to the invention, researches show that the concentration time is controlled to be about 90 ℃, so that a good concentration effect can be achieved, the concentration time is long when the temperature is lower than 70 ℃, and the paste preparation cost is increased.
Compared with the traditional Chinese medicine decoction piece prepared paste formula, the preparation time is obviously shortened, 1 to 2 persons are needed for preparing one pot of paste formula, the whole process can be completed within 2 hours, the paste preparation time is greatly shortened, and the paste preparation efficiency is improved. Meanwhile, the research of the invention discovers that the concentration time is controlled to be about 90 ℃, so that the invention can achieve good concentration effect, the concentration time is long when the concentration time is lower than 70 ℃, and the paste preparation cost is increased.
The preparation method of the Wuyi paste provided by the invention is characterized in that the Wuyi paste is prepared from two raw materials of traditional Chinese medicine decoction pieces and traditional Chinese medicine formula granules, and because the raw materials contain more polysaccharide substances, the temperature is controlled in the concentration process, the caramelization reaction is greatly reduced, the quality of the paste is improved, and the taste of the paste is ensured.
In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above are not necessarily intended to refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, various embodiments or examples and features of different embodiments or examples described in this specification can be combined and combined by one skilled in the art without contradiction.
Although embodiments of the present invention have been shown and described above, it will be understood that the above embodiments are exemplary and not to be construed as limiting the present invention, and that changes, modifications, substitutions and alterations can be made to the above embodiments by those of ordinary skill in the art within the scope of the present invention.

Claims (10)

1. The Wuyi paste is characterized by being prepared from the following raw material medicines in parts by weight: 120-180 parts of fragrant solomonseal rhizome, 150-200 parts of astragalus (roasted), 150-200 parts of largehead atractylodes rhizome, 120-180 parts of prepared rhizome of rehmannia and 120-180 parts of barbary wolfberry fruit.
2. The five-component beneficial paste for people with qi-deficiency constitution according to claim 1, which is prepared from the following raw material medicines in parts by weight: 120-180 parts of polygonatum odoratum, 180-200 parts of astragalus (roasted), 180-200 parts of bighead atractylodes rhizome, 120-150 parts of prepared rhizome of rehmannia and 120-150 parts of wolfberry fruit.
3. The five-component beneficial paste for people with qi-deficiency constitution according to claim 2, wherein the five-component beneficial paste is prepared from the following raw material medicines in parts by weight: 150 parts of polygonatum odoratum, 180 parts of astragalus root (roasted), 180 parts of bighead atractylodes rhizome, 150 parts of prepared rhizome of rehmannia and 150 parts of wolfberry fruit.
4. A preparation method of Wuyi paste suitable for qi deficiency constitution is characterized by comprising the following steps of soaking, decocting, concentrating, collecting paste and cooling the paste, and the preparation method comprises the following steps:
first-step weighing: weighing the raw material components in the form of the traditional Chinese medicine decoction pieces according to the raw material component proportion of the five-component beneficial paste of any one of claims 1 to 3;
the second step of water extraction: putting all the raw material components into a clean earthen pot, a copper pot or a stainless steel pot with the same volume, and completely immersing and soaking the medicinal materials (for decocting the first decoction) by 6-12 times of water for 1 hour; heating and decocting the soaked medicinal materials, boiling at 100 ℃, then boiling for about 1-2 hours with slow fire, then gradually concentrating the medicinal liquid, filtering out the first medicinal liquid with gauze or a 24-40 mesh sieve, adding 6 times of water for decocting, boiling with strong fire before the same decocting method, and then decocting for about 1 hour with slow fire, thus obtaining second decoction; filtering out the medicinal liquid, and removing the medicinal residue; mixing the decoctions, standing, and precipitating or filtering with 100 mesh sieve;
and a third step of concentration: pouring the filtered medicine juice into a pot, concentrating, wherein strong fire can be used for accelerating water evaporation, floating foam is skimmed at any time, the medicine juice slowly becomes thick, slow fire (85 ℃) is used for further concentration, stirring is continuously carried out at the moment until the medicine juice is not scattered on paper, decocting can be suspended at the moment, the medicine juice is the concentrated clear paste, the concentrated clear paste is concentrated to the relative density of 1.02-1.05, the concentration temperature is 70-90 ℃, and the weight of the clear paste is weighed;
the fourth step of paste collection: mixing the following materials in percentage by weight of honey: honey weight =1:0.4 to 0.5 of the paste is poured into the clear paste, the clear paste is slowly boiled over small fire and is continuously stirred by a shovel, and the paste is concentrated until the liquid medicine is soaked in fish eyes and can be pulled into a flag or dripped into beads (the paste is dripped into clear water to be condensed into beads without scattering);
and fifthly, canning: cooling the collected paste, placing into a clean porcelain wide-mouth container, covering the container with clean gauze, standing overnight, cooling completely, covering, and refrigerating in refrigerator.
5. The method for preparing Wuyi paste for qi-deficiency constitution according to claim 4, wherein after the fifth canning step, the method further comprises:
sixth step, quality inspection: and (5) performing quality inspection on the five beneficial pastes. The appearance paste has the advantages of fine texture, proper consistency, no floating foam, no rancidity and no mildew.
6. The method for preparing Wuyi paste according to claim 5, wherein after the sixth canning step, the method further comprises:
step seven, labeling: concentrating the medicinal liquid to obtain paste, cooling slightly, removing water vapor, packaging, adding paste administration instruction, and labeling.
7. A preparation method of Wuyi paste suitable for qi-deficiency constitution is characterized by comprising the following steps of preheating, dissolving, concentrating, paste collecting and paste cooling, and the preparation method comprises the following steps:
first-step weighing: weighing the traditional Chinese medicine raw material particles (the weight of the particles is converted according to the particle standard) according to the raw material proportion of the Wuyi plaster of any one of claims 1 to 3, putting the clean traditional Chinese medicine raw material particles into an inner container of a plaster formula machine, and completely immersing the medicine materials by using 1.5 times of water;
and the second step of setting the paste boiling program: opening the particle paste machine equipment, entering a set interface, setting preheating (cold water dissolution needs preheating, hot water dissolution does not need preheating), dissolution (70 ℃ dissolution, 10 minutes), concentration (concentration temperature is 80-90 ℃, time is 15-20 minutes), paste collection (temperature is 80-90 ℃, time is 10-15 minutes), process flow, time, gear (temperature) and stirring revolution of each process, returning to a main interface after parameter setting is finished, starting operation, automatically heating and stirring, starting paste boiling, concentrating to obtain clear paste with relative density of 1.02-1.05, and weighing the weight of the clear paste at concentration temperature of 70-90 ℃;
and a third step of concentration: when the paste collecting process is started, the weight of the particles is as follows: honey weight =1:0.4 to 0.5 of honey is poured in, the heating and the stirring are continued, the machine is operated, after the standby device is operated, the liquid medicine is soaked in fish eyes, and can be pulled to form a flag or be dripped to form beads (the paste is dripped into clear water to be condensed into beads without dispersion);
fourthly, cooling the paste: cooling, loading into clean wide-mouth container, covering with clean gauze, standing overnight, cooling, covering, and refrigerating.
8. The method for preparing Wuyi paste according to claim 7, wherein after the fourth step of paste cooling, the method further comprises:
fifth step, quality inspection: the appearance paste has the advantages of fine texture, proper consistency, no floating foam, no rancidity and no mildew.
9. The method for preparing Wuyi paste for qi-deficiency constitution according to claim 8, wherein after the fifth step of quality inspection, the method further comprises:
sixth step labeling: concentrating the medicinal liquid to obtain paste, cooling slightly, removing water vapor, packaging, adding paste administration instruction, and labeling.
10. Use of the Wuyi paste of any one of claims 1-3 in the preparation of a medicament for conditioning and improving qi-deficiency constitution.
CN202211076431.7A 2022-09-05 2022-09-05 Wuyi paste suitable for people with qi deficiency constitution, preparation method and application thereof Pending CN115252717A (en)

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