CN115252683A - Method for preparing children cough and asthma granule by adopting one-step granulation - Google Patents
Method for preparing children cough and asthma granule by adopting one-step granulation Download PDFInfo
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Abstract
The invention provides a method for preparing children cough and asthma granule by adopting one-step granulation, which comprises weighing a proper amount of gypsum, bitter apricot seed, liquorice, isatis root, snakegourd fruit, ephedra and honeysuckle; the method comprises the following specific steps: step 1: decocting Gypsum Fibrosum, semen Armeniacae amarum, glycyrrhrizae radix, radix Isatidis, and fructus Trichosanthis with 10-12 times of water for 1 hr, and filtering; step 2: decocting the dregs of the step 1, the ephedra herb and the honeysuckle flower by adding 6-8 times of water for 1 hour, and filtering; and step 3: mixing the filtrates in the steps 1 and 2, standing, filtering to obtain supernatant, and concentrating to obtain fluid extract; and 4, step 4: adding ethanol, stirring, refrigerating for 12-48 hr, and filtering to obtain supernatant; and 5: adding sucrose powder and dextrin, and granulating. The invention solves the technical problem that the finished product of the children cough and asthma treating granules prepared by the prior art has lower chlorogenic acid content, ensures the accessibility of production raw materials, reduces the purchasing and manufacturing cost and simultaneously improves the product quality.
Description
Technical Field
The invention relates to the technical field of pharmaceutical preparations, in particular to a method for preparing children cough and asthma treating granules by adopting one-step granulation.
Background
The infantile cough and asthma particle is classified into 11 types of new drugs according to the registration of the original traditional Chinese medicine, namely the imitation drugs, the execution standard is WS3-B-0688-91-5, and the functions and the main indications of the infantile cough and asthma particle are as follows: dispersing lung qi, clearing heat, relieving cough, eliminating phlegm, and relieving asthma, and can be used for treating upper respiratory infection, tracheitis, pneumonia, cough, etc.
The main active ingredient of the product is chlorogenic acid, and the chlorogenic acid has wide biological activity and has the effects of resisting bacteria, diminishing inflammation, resisting viruses, increasing white blood cells, protecting liver and gallbladder, resisting tumors, reducing blood pressure, reducing blood fat, eliminating free radicals, exciting the central nervous system and the like according to modern pharmacological results, wherein the functions of the product for resisting bacteria and diminishing inflammation are closely related to the main function of the product. The theory of the traditional Chinese medicine holds that honeysuckle (monarch drug containing chlorogenic acid) is sweet and cold, enters the channels of the lung, heart and stomach, has the effects of clearing away heat and toxic materials and dispelling wind and heat, and can be used for treating carbuncle, furuncle, pharyngitis, erysipelas, heat toxin and bloody dysentery, wind-heat type common cold, epidemic febrile disease and fever. Therefore, ensuring the content of chlorogenic acid in the product plays an important role in the quality of the product.
The property of the chlorogenic acid is unstable, and the chlorogenic acid is greatly influenced by high temperature, strong light and Ph, so that the chlorogenic acid is degraded; although the chlorogenic acid content in the children cough and asthma relieving granules meets the requirements according to the quality standard, the chlorogenic acid content is close to the limit, in order to ensure the product quality, a very high requirement has to be provided for honeysuckle medicinal materials, the chlorogenic acid content in the honeysuckle must reach more than 3.3%, and the chlorogenic acid content in the honeysuckle specified in the pharmacopoeia of the people's republic of China is 1.5%, and the content is more than one time higher than the limit, so that the product has very high requirements for honeysuckle medicinal materials in order to meet the quality requirements of finished products under the existing process conditions, the purchasing cost and difficulty of enterprises are increased, and the manufacturing cost of the product is increased, so that the invention has very important value for solving the product problem by using a method suitable for a commercial production process.
Disclosure of Invention
The invention aims to provide a method for preparing children cough and asthma relieving granules by adopting one-step granulation, which aims to solve the technical problem that the content of chlorogenic acid in finished products of the children cough and asthma relieving granules prepared by adopting the prior art is lower, simultaneously solve the accessibility problem of honeysuckle medicinal materials and realize the reduction of purchase and manufacturing costs. Therefore, the implementation of the method not only solves the technical problem of lower chlorogenic acid content in the children cough and asthma relieving granule in the prior art, but also ensures the accessibility of production raw materials, reduces the purchase and manufacturing cost and improves the product quality.
In order to solve the technical problems, the technical scheme adopted by the invention is as follows:
a method for preparing infantile cough and asthma granule by one-step granulation comprises weighing appropriate amount of Gypsum Fibrosum, semen Armeniacae amarum, glycyrrhrizae radix, radix Isatidis, fructus Trichosanthis, herba Ephedrae and flos Lonicerae;
the method comprises the following specific steps:
step 1: decocting Gypsum Fibrosum, semen Armeniacae amarum, glycyrrhrizae radix, radix Isatidis, and fructus Trichosanthis with 10-12 times of water for 1 hr, and filtering;
and 2, step: decocting the dregs of the step 1, the ephedra herb and the honeysuckle flower by adding 6-8 times of water for 1 hour, and filtering;
and step 3: mixing the filtrates in the steps 1 and 2, standing, filtering to obtain supernatant, and concentrating to obtain fluid extract;
and 4, step 4: adding ethanol in an amount which is one time, stirring uniformly, refrigerating for 12-48 hours, filtering to obtain supernatant, recovering ethanol, and concentrating until the relative density is 1.10-1.14;
and 5: adding sucrose powder and dextrin for further granulation;
step 6: drying;
and 7: sieving and then carrying out total mixing;
and 8: and (6) subpackaging and packaging.
In step 5, the granulation parameters are as follows: material temperature: 56-65 ℃; atomization pressure: 0.05-0.08MPa; feeding speed: 12-16rpm; fan frequency: 25-45HZ; the bag shaking time is set to be 60-120S during granulation, and the times are set to be 3-5 times.
Further optimizing, in the step 5, the weight ratio of the sucrose powder to the dextrin is 5:1-2:1.
Wherein, in step 7, a No. 1 sieve is adopted for sieving.
Further limiting, in the step 1, gypsum 937.5g, bitter apricot kernel 312.5g, licorice root 312.5g, isatis root 625g and trichosanthes kirilowii 312.5g; in step 2, 62.5g of ephedra herb and 625g of honeysuckle flower.
Wherein, in the step 6, the water content is controlled to be 1-3% during drying.
Compared with the prior art, the invention has the following beneficial effects:
the components in the invention are consistent with the components in the prior art, so that the material basis of the product is ensured to be consistent before and after the invention, and the safety of the product is not influenced; meanwhile, when the one-step granulation is carried out, the extract with low density is used for granulation, the heating time is short when the extract is concentrated, and the paste collecting temperature is lower; during granulation and drying, compared with wet granulation, the material drying time is short, the temperature is low, the influence of the temperature on the content of chlorogenic acid is reduced, the content of the chlorogenic acid is further improved, and the quality of the product is improved;
the invention adopts a one-step granulation mode, and the transfer rate of chlorogenic acid from medicinal materials to finished products is obviously improved, so that honeysuckle medicinal materials do not need to be strictly controlled and can meet pharmacopoeia standards, the accessibility of the medicinal materials is improved, the purchasing difficulty and cost can be reduced, and the production cost of products is reduced; compared with the original process, the one-step granulation process saves working hours, reduces energy consumption, reduces the production cost of the product and improves the competitiveness of the product; meanwhile, the quality is better. The total performance is in two aspects, in the content aspect, the sample prepared by adopting one-step granulation is obviously higher than that of a sample prepared by wet granulation, the curative effect is better, in the solubility aspect, the particles prepared by one-step granulation are in a porous structure, the heating time of the material is shortened, and the heating is more uniform, so the solubility is better, the materials can be completely dissolved, and the materials are clear and transparent.
Detailed Description
In the following, only certain exemplary embodiments are briefly described. As those skilled in the art will recognize, the described embodiments may be modified in various different ways, all without departing from the spirit or scope of the embodiments of the invention.
Example one
The embodiment discloses a method for preparing children cough and asthma granules by adopting one-step granulation, which comprises the steps of weighing a proper amount of gypsum, bitter apricot seeds, liquorice, isatis roots, snakegourd fruits, ephedra and honeysuckle;
the method comprises the following specific steps:
step 1: decocting Gypsum Fibrosum, semen Armeniacae amarum, glycyrrhrizae radix, radix Isatidis, and fructus Trichosanthis with 10-12 times of water for 1 hr, and filtering;
step 2: decocting the dregs of the step 1, the ephedra herb and the honeysuckle flower by adding 6-8 times of water for 1 hour, and filtering;
and step 3: mixing and standing the filtrates in the steps 1 and 2, filtering to obtain supernatant, and concentrating to obtain fluid extract;
and 4, step 4: adding ethanol in an amount which is one time, stirring, refrigerating for 12-48 hours, preferably 24 hours, filtering to obtain supernatant, recovering ethanol, and concentrating to relative density of 1.10-1.14;
and 5: adding sucrose powder and dextrin to perform one-step granulation;
step 6: drying;
and 7: sieving and then carrying out total mixing;
and step 8: and (6) subpackaging and packaging.
In step 5, the granulation parameters are as follows: material temperature: 56-65 ℃; atomization pressure: 0.05-0.08MPa; feeding speed: 12-16rpm; fan frequency: 25-45HZ; the bag shaking time is set to be 60-120S during the granulation, and the times are set to be 3-5 times.
Further optimizing, in the step 5, the weight ratio of the sucrose powder to the dextrin is 5:1-2:1.
Wherein, in the step 7, a No. 1 sieve is adopted for sieving.
Further limiting, in the step 1, gypsum 937.5g, bitter apricot kernel 312.5g, liquorice 312.5g, isatis root 625g and trichosanthes 312.5g; in step 2, 62.5g of ephedra herb and 625g of honeysuckle flower.
Further optimization, in step 6, the moisture content is controlled to be 1-3% during drying.
In actual use, in the step 2, the decoction dregs in the step 1 are added into the step 2 for decoction, and the effective components in the decoction dregs are dissolved in water by multiple times of decoction.
To facilitate a further understanding of the invention by those skilled in the art, the invention is further described below in conjunction with specific embodiments.
Case one
In order to ensure that the material basis of the variety is not changed and the safety, effectiveness and quality controllability of the product are not influenced, the prescription and the extraction process are as follows:
prescription:
62.5g of ephedra herb, 625g of honeysuckle flower, 312.5g of bitter apricot seed, 625g of indigowoad root, 3242 g of gypsum, 937.5g, 312.5g of liquoric root and 312.5g of snakegourd fruit
The preparation method of the extract comprises the following steps:
(1) Decocting Gypsum Fibrosum, semen Armeniacae amarum, glycyrrhrizae radix, radix Isatidis, and fructus Trichosanthis with 12 times of water for 1 hr, and filtering;
(2) Decocting the residue, herba Ephedrae and flos Lonicerae with 8 times of water for 1 hr, and filtering;
(3) Mixing the filtrates of (1) and (2), standing, collecting supernatant, and concentrating to obtain fluid extract;
(4) Adding ethanol in an amount which is one time, stirring, refrigerating for 12-48 hours, filtering to obtain supernatant, recovering ethanol, and concentrating at 55-65 deg.C until the relative density is 1.10;
the sucrose powder and the dextrin with the weight ratio of 5:1 are granulated in one step, and the granulation process parameters are as follows:
material temperature: 55-65 ℃, preferably 60 ℃;
atomization pressure: 0.05-0.08MPa, preferably 0.07MPa;
feeding speed: 12-16rpm, preferably 14rpm;
air inlet frequency: 25-45HZ, preferably 38HZ;
the bag shaking time is set to be 60S, and the times are set to be 3;
drying, controlling water content below 3%, sieving with No. 1 sieve, mixing for 10min, and packaging at a ratio of 2 g/bag.
Case two
The method is basically the same as the first method, and is different from the first method in that the density of the extract in the first method is 1.118, the weight ratio of the sucrose powder to the dextrin is 4:1, and the granulation process parameters are as follows:
material temperature: preferably 60 ℃;
atomization pressure: preferably 0.07MPa;
feeding speed: preferably 14rpm;
air inlet frequency: preferably 38HZ;
the bag shaking time is set to be 100S, and the times are set to be 4 times;
drying, controlling water content below 3%, sieving with No. 1 sieve, mixing for 10min, and packaging at a ratio of 2 g/bag.
Case three
The method is basically the same as the first method, and is different from the first method in that the extract density is 1.14, the weight ratio of sucrose powder to dextrin is 3:1, and the granulation process parameters are as follows:
material temperature: preferably 60 ℃;
atomization pressure: preferably 0.07MPa;
feeding speed: preferably 14rpm;
air inlet frequency: preferably 38HZ;
the bag shaking time is set to be 120S, and the times are set to be 5 times;
drying, controlling water content below 3%, sieving with No. 1 sieve, mixing for 10min, and packaging at a ratio of 2 g/bag.
Case four
The method is basically the same as the first method, and is different in that the method reduces the dosage of dextrin and powdered sugar to 70% of the original weight for one-step granulation, the density of the extract is 1.14, the weight ratio of sucrose powder to dextrin is 2:1 for one-step granulation, and the granulation process parameters are as follows:
material temperature: preferably 60 ℃;
atomization pressure: preferably 0.07MPa;
feeding speed: preferably 14rpm;
air inlet frequency: preferably 38HZ;
the bag shaking time is set to be 120S, and the times are set to be 5 times;
drying, controlling water content below 3%, sieving with No. 1 sieve, mixing for 10min, and packaging at a weight of 1.5 g/bag.
To facilitate a further understanding of the invention by those skilled in the art, the invention will be further illustrated from the following points:
1. in order to examine the influence of the proportion of the sucrose powder and the dextrin as auxiliary materials on the particle size, the following results of mixing the sucrose powder and the dextrin as auxiliary materials in different proportions are shown in the following table, wherein the sucrose powder and the dextrin are respectively selected in proportion: 5:1, 4:1, 3:1 and 2:1;
when the weight ratio of the sucrose to the dextrin is 5:1-2:1, the granulation effect is similar, and when the weight ratio is 5:1, the effect is optimal, and the dissolubility meets the requirement.
2. In order to investigate the influence of different extract densities on granulation and molding, the molding process investigation is respectively carried out on the extracts with different densities, and the particle size and the moisture are taken as judgment indexes, wherein the extract densities are specifically as follows: 1.25, 1.20, 1.14 and 1.10, as follows:
the results show that the density of the extract has great influence on the granulation granularity; when the density of the extract is 1.10-1.14, the granularity index of the prepared particles is better; when the density of the extract is 1.10, the granularity index of the particles is optimal.
3. In order to investigate the influence of different atomization pressures on granulation forming, the forming process investigation is respectively carried out on different atomization pressures, the particle size and the moisture are taken as judgment indexes, the atomization pressures are specifically 0.08MPa, 0.07MPa, 0.06MPa, 0.05MPa and 0.04MPa, and the specific conditions are as follows:
when the atomization pressure is too low, the relative size of the fogdrops is larger, under the condition of certain material temperature, the moisture is not in time to evaporate, the agglomeration and bed collapse are easy to occur, and when the atomization pressure is 0.05-0.07, the granulation effect is best.
4. In order to investigate the influence of different material temperatures on granulation and forming, the forming process investigation is respectively carried out on the different material temperatures, and the granularity, the moisture and the content are taken as judgment indexes, wherein the specific conditions are as follows:
from the results, the particle size and the content of the granules meet the quality requirements when the granules are granulated at various material temperatures, but the particle sizes of the granules prepared at the material temperatures of 56-60 and 61-65 are better than those of the granules prepared at 50-55, and meanwhile, the material has the phenomenon of viscosity when the granulating temperature is 50-55 ℃ in the granulating process.
5. In order to investigate the influence of different feeding speeds on granulation and forming, forming process investigation is respectively carried out on different feeding speeds, and the particle size and the moisture are taken as judgment indexes, wherein the specific conditions are as follows:
the feeding speed is 12-16rpm, the further granulation can be carried out, and the preparation effect is better.
The granulation parameters in step 5 of the invention can improve the quality of the product.
The preparation method of the first case is adopted to prepare the children cough and asthma treating granules, three batches of process confirmation samples are respectively detected according to quality standards, and the detection result meets the quality requirement. The specific situation is as follows:
in order to facilitate the further understanding of the invention by the technicians in the field, the invention adopts medicinal materials with different contents for production, the original process (wet granulation process) adopts honeysuckle medicinal materials with high content for production, and the new process (one-step granulation process) adopts honeysuckle with common content for production; the comparison results of the content and the dissolubility of the product before and after the invention are as follows:
that is, under the condition of the same raw materials and only different granulation processes, the content of chlorogenic acid is obviously different and nearly doubled, and the effect is obvious, so that the effect of improving the curative effect is achieved, and meanwhile, the novel process is better in the aspect of dissolubility. Meanwhile, the purchasing difficulty and purchasing cost of the medicinal materials are obviously reduced, and the aims of reducing cost and improving efficiency are fulfilled.
The invention compares the manual work and working hours of the front and back procedures, and takes the production of 800kg of granules as an example.
Example two
The invention also discloses another method for preparing the children cough and asthma relieving granules by adopting one-step granulation, the method can effectively improve the content of chlorogenic acid in the children cough and asthma relieving granules, and the chlorogenic acid is prevented from being damaged and explained in the preparation process;
the specific method comprises weighing appropriate amount of Gypsum Fibrosum, semen Armeniacae amarum, glycyrrhrizae radix, radix Isatidis, fructus Trichosanthis, herba Ephedrae and flos Lonicerae;
the method comprises the following specific steps:
step S101: gypsum Fibrosum 937.5g, semen Armeniacae amarum 312.5g, glycyrrhrizae radix 312.5g, radix Isatidis 625g, and fructus Trichosanthis 312.5g by decocting in 10-12 times of water for 1 hr, and filtering;
s102: decocting herba Ephedrae with 6-8 times of water, and filtering to obtain solution A;
s103: carrying out low-pressure countercurrent extraction on honeysuckle and 6-8 times of water at the low temperature of 40-50 ℃ of minus 0.06 to minus 0.80 to obtain a solution B;
s104: mixing the filtrate obtained in the step S101 with the solutions A and B, standing, taking supernatant, and concentrating into fluid extract;
step S105: adding ethanol in an amount which is one time, stirring, refrigerating for 12-48 hours, filtering to obtain supernatant, recovering ethanol, and concentrating at 60-65 deg.C until the relative density is 1.10-1.14;
step S106: adding a proper amount of sucrose powder and dextrin for one-step granulation, wherein the weight ratio of the sucrose powder to the dextrin is 5:1-2:1, and the granulation parameters are as follows:
material temperature: 56-65 ℃;
atomization pressure: 0.05-0.08MPa;
feeding speed: 12-16rpm;
fan frequency: 25-45HZ;
the bag shaking time is set to be 60-120S, and the times are set to be 3-5;
s107: drying, sieving, and packaging.
Further optimizing, crushing the weighed ephedra, preparing a hydrochloric acid solution with the pH =3-5, soaking the crushed ephedra for 30min, and then decocting and filtering.
Compared with the first embodiment, the present embodiment is mainly different from the first embodiment in the treatment of ephedra herb and honeysuckle flower; the herba Ephedrae is dry grass stem of Ephedra sinica Stapf, ephedra intermedia as chrenk C.A.Mey. Or Ephedra equiseti Bge. Of Ephedra equiseti, contains various components such as alkaloid, flavone, flavan, tannin, volatile oil, organic acid, polysaccharide, etc., and the separated herba Ephedrae alkaloid includes ephedrine, pseudoephedrine, ephedrine, ephedra dioxane, etc., wherein, the ephedrine and the pseudoephedrine are effective components with the function of relieving asthma in the particles for cough and asthma due to lung heat of children, the ephedrine (also called as ephedrine) is levorotatory or racemic body, the pseudoephedrine (also called as pseudoephedrine) is dextrorotatory body of the ephedrine, the ephedrine and the pseudoephedrine are isomers of each other, the two have different properties in the aspects of solubility, acid-base property and the like, and the ephedrine hydrochloride and the pseudoephedrine hydrochloride are respectively the hydrochlorides of the ephedrine and the pseudoephedrine.
In the embodiment, the ephedra is crushed, so that the extraction of ephedrine and pseudoephedrine is realized more quickly; meanwhile, after being soaked in hydrochloric acid solution with the pH =3-5, ephedrine and pseudoephedrine hydrochloride can be conveniently generated, and under the action of soaking and decocting, the effective components of the ephedra can be better dissolved in the solution, so that the efficient extraction of the effective components of the ephedra is improved.
More importantly, in the extraction process, the low-pressure countercurrent extraction can avoid the decomposition and loss of chlorogenic acid caused by local high heat on the honeysuckle close to the bottom of the frying pan during decoction, so that the extraction is more sufficient and uniform in heating, and the decomposition and loss of chlorogenic acid are reduced; meanwhile, the one-step granulation adopts the granulation of the extract with low density, so that the heating time is short when the extract is concentrated, and the paste collection temperature is lower; during granulation and drying, compared with wet granulation, the material drying time is short and the temperature is low. Further, the chlorogenic acid content in the honeysuckle can be effectively preserved, and the conversion rate of the chlorogenic acid in the honeysuckle is improved to the maximum extent. Compared with the preparation method described in the first embodiment, the preparation method described in this embodiment can further improve the conversion rate of chlorogenic acid in honeysuckle, improve the content of chlorogenic acid in the product, and improve the effective components in ephedra.
While preferred embodiments of the present invention have been described, additional variations and modifications in those embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. Therefore, it is intended that the appended claims be interpreted as including the preferred embodiment and all changes and modifications that fall within the scope of the invention.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, it should be noted that any modifications, equivalents and improvements made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (6)
1. A method for preparing infantile cough and asthma granule by one-step granulation comprises weighing appropriate amount of Gypsum Fibrosum, semen Armeniacae amarum, glycyrrhrizae radix, radix Isatidis, fructus Trichosanthis, herba Ephedrae and flos Lonicerae;
the method comprises the following specific steps:
step 1: decocting Gypsum Fibrosum, semen Armeniacae amarum, glycyrrhrizae radix, radix Isatidis, and fructus Trichosanthis with 10-12 times of water for 1 hr, and filtering;
step 2: decocting the dregs of the step 1, the ephedra herb and the honeysuckle flower by adding 6-8 times of water for 1 hour, and filtering;
and step 3: mixing and standing the filtrates in the steps 1 and 2, filtering to obtain supernatant, and concentrating to obtain fluid extract;
and 4, step 4: adding ethanol in an amount which is a multiple of that of the raw materials, stirring uniformly, refrigerating for 12-48 hours, filtering to obtain supernate, recovering ethanol, and concentrating until the relative density is 1.10-1.14;
and 5: adding sucrose powder and dextrin for further granulation;
step 6: drying;
and 7: sieving and then carrying out total mixing;
and 8: and (6) subpackaging and packaging.
2. The method for preparing the Xiao' er Kechuanling granule with one-step granulation according to claim 1, wherein: in step 5, the granulation parameters were as follows: material temperature: 56-65 ℃; atomization pressure: 0.05-0.08MPa; feeding speed: 12-16rpm; fan frequency: 25-45H; the bag shaking time is set to be 60-120S during granulation, and the times are set to be 3-5 times.
3. The method for preparing the Xiao' er Kechuanling granule with one-step granulation according to claim 1, wherein: in the step 5, the weight ratio of the sucrose powder to the dextrin is 5:1-2:1.
4. The method for preparing the Xiao' er Kechuanling granule with one-step granulation according to claim 1, wherein: in step 7, a No. 1 sieve is used for sieving.
5. The method for preparing the Xiao' er Kechuanling granule with one-step granulation according to claim 1, wherein: in the step 1, gypsum 937.5g, bitter apricot kernel 312.5g, licorice root 312.5g, isatis root 625g and snakegourd fruit 312.5g; in step 2, 62.5g of ephedra herb and 625g of honeysuckle flower.
6. The method for preparing the Xiao' er Kechuanling granule with one-step granulation according to claim 1, wherein: in step 6, during drying, the water content is controlled to be 1-3%.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105395956A (en) * | 2015-12-30 | 2016-03-16 | 武汉钧安制药有限公司 | Traditional Chinese medicine composition for treating anemopyretic cold and preparing method and quality control method thereof |
| CN110292597A (en) * | 2019-05-28 | 2019-10-01 | 海南海力制药有限公司 | A kind of Chinese medicinal granule that treating children's dyspneic cough and preparation method |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105395956A (en) * | 2015-12-30 | 2016-03-16 | 武汉钧安制药有限公司 | Traditional Chinese medicine composition for treating anemopyretic cold and preparing method and quality control method thereof |
| CN110292597A (en) * | 2019-05-28 | 2019-10-01 | 海南海力制药有限公司 | A kind of Chinese medicinal granule that treating children's dyspneic cough and preparation method |
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| 张燕平;刘萍: "中药流化床制粒技术的应用与发展" * |
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