CN110292597A - A kind of Chinese medicinal granule that treating children's dyspneic cough and preparation method - Google Patents
A kind of Chinese medicinal granule that treating children's dyspneic cough and preparation method Download PDFInfo
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Abstract
The present invention provides a kind of Chinese medicinal granules and preparation method thereof for treating children's dyspneic cough.The Chinese medicinal granule for the treatment of children's dyspneic cough provided by the invention comprising 936.5-938.5 parts of gypsum, 312-313.5 portions of semen armeniacae amaraes, 311.5-313 portions of Radix Glycyrrhizaes, 623.5-626 parts of Radix Isatidis, 311-314 parts of Snakegourd Fruits, 61-64 portions of Chinese ephedras, 623-626 portions of honeysuckles, dextrin and sucrose；The weight of dextrin is 255-260 parts, and the weight ratio of dextrin and sucrose is 1:2.It is learnt by experimental analysis, the weight ratio discussion of dextrin and sucrose, discovery is when the weight ratio of dextrin and sucrose is 1:2, it shows as all dissolving in terms of melting, slight turbid, rate of body weight gain 8.32%, requirement is reached, hardness is to meet the requirements compared with hard state.It can be seen that multiple properties of obtained drug granule have obtained good control when the weight ratio.
Description
Technical field
The present invention relates to a kind of processing methods of Chinese medicinal component, and in particular to a kind of Chinese medicinal granule for treating children's dyspneic cough
And preparation method thereof.
Background technique
Children's dyspneic cough can be divided into acute cough and asthma and chronic cough and asthma, belong to a kind of chronic airway inflammation disease, be a kind of immune
Property inflammation, its main feature is that Airway reversibility is narrow and causes to have difficulty in breathing, its clinical manifestation be it is out of breath, cough, cough up phlegm, exhaling
Wheezing sound can be heard by inhaling difficult, intrapulmonary, and wheezing sound is more obvious when especially exhaling, children's dyspneic cough breaking-out Shi Keyong antiasthmatic
Object is alleviated, and can also voluntarily alleviate, and is alleviated with drug the most common are infusion grain for cough and asthma of children, and the ingredient of the drug is mainly
Chinese ephedra, honeysuckle, semen armeniacae amarae, Radix Isatidis, gypsum, Radix Glycyrrhizae, Snakegourd Fruit, dextrin and sucrose, the drug cure mainly promoting the dispersing function of the lung, heat-clearing, only
Cough, eliminating the phlegm.For coughing caused by the infection of the upper respiratory tract.
Melting and hygroscopicity are two important quality control indexs of this granule medicament, however, in existing skill
In art method, the control of the two parameters is often difficult to achieve the effect that satisfied, is easy to appear in terms of melting muddy
Problem, the partially soft or two kinds of indexs of hardness aspect conflict with each other and are difficult to take into account.
Summary of the invention
The purpose of the present invention is to provide the meltings and hygroscopicity of a kind of Chinese medicinal granule to this treatment children's dyspneic cough
It is more preferably controlled, improves the preparation method for melting the Chinese medicinal granule for the treatment of children's dyspneic cough of performance and stiffness issue.
In order to complete above-mentioned purpose, the invention adopts the following technical scheme: a kind of Chinese medicinal granule for treating children's dyspneic cough
Preparation method comprising following steps:
S1: 936.5-938.5 parts of gypsum, 312-313.5 portions of semen armeniacae amaraes, 311.5-313 portions of Radix Glycyrrhizaes, 623.5-626 parts are taken
Radix Isatidis and 311-314 parts of Snakegourd Fruit gomi herbs, are put into extractor, add water, decoct, filtration, obtain the dregs of a decoction and the first filter
Liquid；
S2: and then 61-64 portions of Chinese ephedras and 623-626 parts of two taste medicinal materials of honeysuckle is taken to be added in the dregs of a decoction, add water, decocts, filter
It crosses, obtains second of filtrate；
The first filtrate and second of filtrate are mixed, stand, take supernatant by the step of S3: mixing and thick paste processed
The supernatant of acquirement is placed in concentration tank the liquid extract for being condensed into that relative density is 1.05-1.08, by liquid extract and second by liquid
Alcohol is placed in Alcohol-settling tank, is stirred evenly, and is refrigerated and is stood at 2-10 DEG C, and supernatant is taken, and recycles ethyl alcohol, is condensed into thick paste, surveys fiber crops
Yellow alkali content；
S4: granulation and packaging: above-mentioned thick paste and dextrin and cane sugar powder are taken, is placed in mixing machine and mixes the weight of the dextrin
Amount is 255-260 parts, and the weight ratio of the dextrin and sucrose is 1:2, and softwood is made, softwood is sieved, is made wet
Grain, wet granular is placed in drying machine, and dry dry particl or thick paste and dextrin and cane sugar powder pass through one-step palletizing legal system
Dry particl is obtained, crosses and weeds out fine powder, then after weeding out bulky grain, surveys the content of moisture, ephedrine, chooses qualified particle, packet
Dress.
The invention has the benefit that discovery exists by weight ratio discussion of the embodiment part about dextrin and sucrose
It when the weight ratio of dextrin and sucrose is 1:2, shows as all dissolving in terms of melting, slight turbid, rate of body weight gain is
8.32%, reach requirement, hardness is to meet the requirements compared with hard state.It can be seen that when the weight ratio, obtained drug
Multiple properties of particle have obtained good control.
One Preferable scheme is that, in S1, be put into extractor, add 10 times amount water, decoct 1 hour；In S2
In, add the water of 9 times of amounts, decocts 1 hour；In S3, the ethyl alcohol that the mass fraction that liquid extract and one times are measured is 95% is placed in alcohol
In heavy tank, time of repose is 12-48 hour；It is 1 hour dry in 60-65 DEG C；In S4, softwood is crossed into 12 meshes, is made
Wet granular, fine powder cross 24 meshes and remove bulky grain.
One Preferable scheme is that, the parts by weight of the gypsum are 937.5 parts, and the amygdalate parts by weight are 312.5
Part, the parts by weight of the Radix Glycyrrhizae are 312.5 parts, and the parts by weight of the Radix Isatidis are 625 parts, and the Snakegourd Fruit parts by weight are
312.5 parts, the parts by weight of the Chinese ephedra are 62.5 parts, and the parts by weight of the honeysuckle are 625 parts, the weight of the dextrin
Part is 257 parts, and the parts by weight of the sucrose are 514 parts.
One Preferable scheme is that, in S3, be condensed into relative density be 1.36-1.40 thick paste；With dextrin and sucrose
Powder obtains product particle by wet granulation.
Alternatively, relative density is condensed into S3 as the thick paste of 1.24-1.29, and 1.24-1.29 relative density
Thick paste and dextrin and cane sugar powder pass through one-step palletizing and obtain product particle.
A kind of Chinese medicinal granule for treating children's dyspneic cough comprising 936.5-938.5 parts of gypsum, 312-313.5 portions of bitter apricots
Benevolence, 311.5-313 portions of Radix Glycyrrhizaes, 623.5-626 parts of Radix Isatidis, 311-314 parts of Snakegourd Fruits, 61-64 portions of Chinese ephedras, 623-626 parts of gold and silver
Flower, dextrin and sucrose；The weight of dextrin is 255-260 parts, and the weight ratio of the dextrin and sucrose is 1:2.
One Preferable scheme is that, the parts by weight of the gypsum are 937.5 parts, and the amygdalate parts by weight are 312.5
Part, the parts by weight of the Radix Glycyrrhizae are 312.5 parts, and the parts by weight of the Radix Isatidis are 625 parts, and the Snakegourd Fruit parts by weight are
312.5 parts, the parts by weight of the Chinese ephedra are 62.5 parts, and the parts by weight of the honeysuckle are 625 parts, the weight of the dextrin
Part is 257 parts, and the parts by weight of the sucrose are 514 parts.
Detailed description of the invention
Fig. 1 is preparation technology flow chart of the invention.
Fig. 2 is the equipment of the embodiment of the present invention structural schematic diagram.
Specific embodiment
Below with reference to embodiment, the present invention is described in detail, but it should be stated that, these embodiments are not
Limitation of the present invention, those of ordinary skill in the art according in embodiment work done energy, method or the structure etc.
Effect transformation or substitution, all belong to the scope of protection of the present invention within.
Embodiment 1:
The prescription dosage of the Chinese medicinal granule of the treatment children's dyspneic cough of the present embodiment is (being made 1000 bags) as shown in the table:
| Component | Parts by weight |
| Chinese ephedra | 62.5 |
| Honeysuckle | 625 |
| Semen armeniacae amarae | 312.5 |
| Radix Isatidis | 625 |
| Gypsum | 937.5 |
| Radix Glycyrrhizae | 312.5 |
| Snakegourd Fruit | 312.5 |
| Dextrin | 257 |
| Sucrose | 514 |
As shown in Figure 1, the preparation method of the Chinese medicinal granule of the treatment children's dyspneic cough of the present embodiment, includes the following steps:
S1: extraction step takes gypsum, semen armeniacae amarae, Radix Glycyrrhizae, Radix Isatidis and Snakegourd Fruit gomi herbs, is put into multi-function extractor
It is interior, add the water of 10 times of amounts, decoct 1 hour, filters, obtain the dregs of a decoction and the first filtrate；
S2: then extracting step, and Chinese ephedra and two taste medicinal material of honeysuckle is then taken to be added in the dregs of a decoction, adds 9 times of amounts
Water decocts 1 hour, and filtration obtains second of filtrate；
S3: mixing and thick paste step processed, the first filtrate and second of filtrate are mixed, 2 hours is stood, takes
Clear liquid, the supernatant of acquirement being placed in the reduced pressure tank of ZN-C1000 model and being condensed into relative density is 1.06 (85-90
DEG C heat is surveyed) liquid extract, the ethyl alcohol that the mass fraction that liquid extract and one times are measured is 95% is placed in Alcohol-settling tank, is stirred evenly,
Refrigeration stands 36 hours at 2-10 DEG C, takes supernatant, recycles ethyl alcohol, and being condensed into 1.36~1.40, (75-80 DEG C of heat surveys phase
To density) thick paste, relative density refers to the density relative to water, surveys Content of Ephedrine With；
S4: granulation and packaging step take above-mentioned 1.36~1.40 thick paste of density and ratio for the dextrin and cane sugar powder of 1:2,
It is placed in the trough type mixing machine of CH150 model and mixes, softwood is made, softwood is crossed into 12 meshes, wet granular is made, by wet granular
It is placed in GFG60 HighefficientFluidbeddrier, it is 1 hour dry in 60-65 DEG C, dry particl is obtained, 10 meshes is crossed and removes fine powder, then again
It crosses 24 meshes and removes bulky grain, survey the content of moisture, ephedrine, qualified particle is set in particles packing machine, uses foil laminated film
Packaging.
Embodiment 2:
The prescription dosage of the Chinese medicinal granule of the treatment children's dyspneic cough of the present embodiment is (being made 1000 bags) as shown in the table:
As shown in Figure 1, the preparation method of the Chinese medicinal granule of the treatment children's dyspneic cough of the present embodiment, includes the following steps:
S1: extraction step takes gypsum, semen armeniacae amarae, Radix Glycyrrhizae, Radix Isatidis and Snakegourd Fruit gomi herbs, is put into multi-function extractor
It is interior, add the water of 10 times of amounts, decoct 1 hour, filters, obtain the dregs of a decoction and the first filtrate；
S2: then extracting step, and Chinese ephedra and two taste medicinal material of honeysuckle is then taken to be added in the dregs of a decoction, adds 9 times of amounts
Water decocts 1 hour, and filtration obtains second of filtrate；
S3: mixing and thick paste step processed, the first filtrate and second of filtrate are mixed, 2 hours is stood, takes
Clear liquid, the supernatant of acquirement being placed in the reduced pressure tank of ZN-C1000 model and being condensed into relative density is 1.06 (85-90
DEG C heat is surveyed) liquid extract, the ethyl alcohol that the mass fraction that liquid extract and one times are measured is 95% is placed in Alcohol-settling tank, is stirred evenly,
Refrigeration stands 36 hours at 2-10 DEG C, takes supernatant, recycles ethyl alcohol, and being condensed into 1.24~1.29, (75-80 DEG C of heat surveys phase
To density) thick paste, relative density refers to the density relative to water, surveys Content of Ephedrine With.
S4: granulation and packaging step take above-mentioned 1.24~1.29 thick paste of density and ratio for the dextrin and cane sugar powder of 1:2,
Dry particl is made through one-step-granulating method, crosses 10 meshes and remove fine powder, then remove bulky grain after 24 meshes, survey moisture, ephedrine
Content, qualified particle, sets in particles packing machine, is packed with foil laminated film.
Related experiment in embodiment
Experiment 1: the determination of thick paste relative density
| Component | Parts by weight |
| Chinese ephedra | 25 |
| Honeysuckle | 250 |
| Semen armeniacae amarae | 125 |
| Radix Isatidis | 250 |
| Gypsum | 375 |
| Radix Glycyrrhizae | 125 |
| Snakegourd Fruit | 125 |
400 bags are made by the above prescription dosage, extracts 6 batches, measures the relative density of thick paste respectively, as a result as follows:
| Serial number | Water proposes liquid extract relative density | Alcohol precipitation condensed cream relative density |
| 1 | 1.09 | 1.24 |
| 2 | 1.05 | 1.29 |
| 3 | 1.06 | 1.27 |
| 4 | 1.04 | 1.40 |
| 5 | 1.07 | 1.39 |
| 6 | 1.06 | 1.36 |
It finally determines, it is 1.06 (85-90 DEG C of heat is surveyed) that water, which proposes condensed cream relative density, and alcohol precipitation condensed cream relative density is
1.24~1.29 and 1.36~1.40 (75-80 DEG C of heat is surveyed).
Experiment 2: the determination of supplementary product consumption ratio
According to the relative density of thick paste determined by above-mentioned experiment 2, by dextrin and cane sugar powder according to 2:1,1:1,1:2,1:
3,1:4 ratio is added in extracted thick paste and makes pellet, dry, checks melting (2000 editions annex of Chinese Pharmacopoeia
IC) and hygroscopicity (in loosely capped vial, room temperature, relative humidity 90%, after 5 days survey weight gain), it is as a result as follows:
| Dextrin: sucrose | Melting | Rate of body weight gain % | Hardness |
| 2:1 | It cannot all dissolve | 5.52 | It is harder |
| 1:1 | All dissolve, it is more muddy | 6.36 | It is harder |
| 1:2 | It all dissolves, little cloudy | 8.32 | It is harder |
| 1:3 | It all dissolves, little cloudy | 12.94 | It is softer |
| 1:4 | It all dissolves, little cloudy | It dissolves part | It is softer, it is moist |
By above table it is found that when the ratio of dextrin and cane sugar powder be 1:2 when, the hardness of drug is preferable, melting compared with
Height is determined as best proportion.
Experiment 3: the measurement of yield rate and Content of Ephedrine With
It is as a result as follows according to prescription dosage 10 times of the production of amplification (10000 bags) pilot scale three batches in embodiment:
As above table it is found that the toxic side effect content of the height of drug quality obtained by the prescription dosage and related component
It is small.
In other embodiments, the present invention also provides a kind of equipment, the equipment specifically in preparation method S1 and
The step of S2, optimizes.Because existing equipment is relatively simple in the two steps, the complexity of operation is resulted in this way
Property, for example, in S1, needs various materials to be then transferred into other equipment in extractor mixing and be filtered, and filter residue
It needs to be impregnated with the material in S2 step.Therefore, as shown in Fig. 2, in equipment provided by the invention, including extractor 1,
Extractor 1 has the upper part 2 and lower part 3 of isolation, and the position being isolated has valve mechanism 4 and filter structure 5.Material
After impregnating, filtered after being opened by valve mechanism 4 through filter structure 5, filter residue is trapped on filter structure 5, and filtrate
Into lower part 3, another valve 7 that the filtrate of lower part 3 then passes through bottom is discharged into stop containment drum.Then on keeping
Part 2 is air-tight state, and 2 supplying negative voltage of part upwards, so that the filter residue on filter structure 5 is drawn into upper part again
2, and prevent filter residue to be detached from tank body 1 in the position of suction inlet setting filter element, it is supreme this makes it possible to which filter residue is completely returned to
Part 2, then closes valve mechanism.Chinese ephedra and honeysuckle is added in part then up, and water is added to carry out secondary immersion,
The mixed liquor that secondary immersion obtains is flowed on filter structure again by valve mechanism carries out secondary filter, and lower part is got
Liquid be also flowed into stop containment drum in.Further, extractor has solid feed inlet and liquid addition port, and solid adds
Material mouth has to be counted in powder flow, and liquid addition port has to be counted in liquid flow, is carried out automatic measurement to the material of addition as a result, is kept away
The frequent weighing bring trouble of material is exempted from.
Claims (7)
1. a kind of preparation method for the Chinese medicinal granule for treating children's dyspneic cough, which comprises the following steps:
S1: take 936.5-938.5 parts of gypsum, 312-313.5 portions of semen armeniacae amaraes, 311.5-313 portions of Radix Glycyrrhizaes, 623.5-626 parts of plates blue
Root and 311-314 parts of Snakegourd Fruit gomi herbs, are put into extractor, add water, decoct, and filtration obtains the dregs of a decoction and the first filtrate；
S2: and then 61-64 portions of Chinese ephedras and 623-626 parts of two taste medicinal materials of honeysuckle is taken to be added in the dregs of a decoction, add water, decoct, filtration obtains
To second of filtrate；
The first filtrate and second of filtrate are mixed, stand, take supernatant, will take by the step of S3: mixing and thick paste processed
The supernatant obtained is placed in concentration tank the liquid extract for being condensed into that relative density is 1.05-1.08, and liquid extract and ethyl alcohol are placed in alcohol
It in heavy tank, stirs evenly, refrigerates and stand at 2-10 DEG C, take supernatant, recycle ethyl alcohol, be condensed into thick paste, survey Content of Ephedrine With；
S4: granulation and packaging: above-mentioned thick paste and dextrin and cane sugar powder are taken, is placed in mixing machine and mixes, the weight of the dextrin is
255-260 parts, and the weight ratio of the dextrin and sucrose is 1:2, and softwood is made, softwood is sieved, wet granular is made, it will
Wet granular is placed in drying machine, dry dry particl or thick paste and dextrin and cane sugar powder, is made dry by marumerization
Grain is crossed and weeds out fine powder, then after weeding out bulky grain, surveys the content of moisture, ephedrine, chooses qualified particle, packaging.
2. the preparation method of the Chinese medicinal granule for the treatment of children's dyspneic cough according to claim 1, which is characterized in that in S1,
It is put into extractor, adds the water of 10 times of amounts, decoct 1 hour；In S2, add the water of 9 times of amounts, decocts 1 hour；It, will in S3
The ethyl alcohol that liquid extract and the mass fraction of one times of amount are 95% is placed in Alcohol-settling tank, and time of repose is 12-48 hour；In 60-
It is 1 hour dry in 65 DEG C；In S4, softwood is crossed into 12 meshes, wet granular is made, fine powder crosses 24 meshes and removes bulky grain.
3. the preparation method of the Chinese medicinal granule for the treatment of children's dyspneic cough according to claim 1, which is characterized in that the gypsum
Parts by weight be 937.5 parts, the amygdalate parts by weight are 312.5 parts, and the parts by weight of the Radix Glycyrrhizae are 312.5 parts, described
The parts by weight of Radix Isatidis are 625 parts, and the Snakegourd Fruit parts by weight are 312.5 parts, and the parts by weight of the Chinese ephedra are 62.5 parts, institute
The parts by weight for stating honeysuckle are 625 parts, and the parts by weight of the dextrin are 257 parts, and the parts by weight of the sucrose are 514 parts.
4. the preparation method of the Chinese medicinal granule for the treatment of children's dyspneic cough according to claim 1 or 2, which is characterized in that in S3
In, it is condensed into the thick paste that relative density is 1.36-1.40；It is made pellet with above-mentioned thick paste and mixed dextrin and Icing Sugar wet process.
5. the preparation method of the Chinese medicinal granule for the treatment of children's dyspneic cough according to claim 1 or 2, which is characterized in that, in S3
In, it is condensed into the thick paste that relative density is 1.24-1.29, and the thick paste of 1.24-1.29 relative density and dextrin and cane sugar powder
Product particle is obtained by one-step palletizing.
6. a kind of Chinese medicinal granule for treating children's dyspneic cough, which is characterized in that including 936.5-938.5 parts of gypsum, 312-313.5 parts
Semen armeniacae amarae, 311.5-313 portions of Radix Glycyrrhizaes, 623.5-626 parts of Radix Isatidis, 311-314 parts of Snakegourd Fruits, 61-64 portions of Chinese ephedras, 623-626 parts
Honeysuckle, dextrin and sucrose；The weight of dextrin is 255-260 parts, and the weight ratio of the dextrin and sucrose is 1:2.
7. the preparation method of the Chinese medicinal granule for the treatment of children's dyspneic cough according to claim 1 or 2, which is characterized in that described
The parts by weight of gypsum are 937.5 parts, and the amygdalate parts by weight are 312.5 parts, and the parts by weight of the Radix Glycyrrhizae are 312.5 parts,
The parts by weight of the Radix Isatidis are 625 parts, and the Snakegourd Fruit parts by weight are 312.5 parts, and the parts by weight of the Chinese ephedra are 62.5
Part, the parts by weight of the honeysuckle are 625 parts, and the parts by weight of the dextrin are 257 parts, and the parts by weight of the sucrose are 514 parts.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112618612A (en) * | 2021-01-05 | 2021-04-09 | 海南海力制药有限公司 | Traditional Chinese medicine granule for treating infantile cough and asthma and preparation method thereof |
| CN115252683A (en) * | 2022-08-15 | 2022-11-01 | 红云制药(玉溪)有限公司 | Method for preparing children cough and asthma granule by adopting one-step granulation |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108452203A (en) * | 2018-05-10 | 2018-08-28 | 湖南康尔佳制药股份有限公司 | A kind of preparation method and its preparation system of five-medicine tranquilization particle |
-
2019
- 2019-05-28 CN CN201910450982.7A patent/CN110292597A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108452203A (en) * | 2018-05-10 | 2018-08-28 | 湖南康尔佳制药股份有限公司 | A kind of preparation method and its preparation system of five-medicine tranquilization particle |
Non-Patent Citations (2)
| Title |
|---|
| 张金莲: "《中成药学》", 31 August 2018 * |
| 钟水燕等: "护肝颗粒制剂成型工艺研究", 《中国兽药杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112618612A (en) * | 2021-01-05 | 2021-04-09 | 海南海力制药有限公司 | Traditional Chinese medicine granule for treating infantile cough and asthma and preparation method thereof |
| CN115252683A (en) * | 2022-08-15 | 2022-11-01 | 红云制药(玉溪)有限公司 | Method for preparing children cough and asthma granule by adopting one-step granulation |
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Application publication date: 20191001 |