CN108452203A - A kind of preparation method and its preparation system of five-medicine tranquilization particle - Google Patents
A kind of preparation method and its preparation system of five-medicine tranquilization particle Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A61K9/1605—Excipients; Inactive ingredients
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- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A61J2200/00—General characteristics or adaptations
- A61J2200/40—Heating or cooling means; Combinations thereof
- A61J2200/42—Heating means
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention discloses a kind of preparation methods and its preparation system of five-medicine tranquilization particle, are prepared by following steps：Wheat, pueraria lobata, jujube and Radix Glycyrrhizae are placed in extractor and extracted twice, then the extracting solution extracted twice is mixed, drying and granulating obtains medicinal material dry powder, then after sucrose is pulverized and sieved, with medicinal material dry powder blend, sucrose and dextrin mixing are added, ethyl alcohol dissolving is added, after ethyl alcohol volatilization, it pelletized, dried, screened again, finally packed the qualified particle of screening；And it is prepared by following preparation system：It is extracted twice by extractor first and obtains extracting solution; by extracting solution in storage in-tank mixing; then medicinal material dry powder is dried to obtain by concentration tank concentration and spray drying tower; medicinal material dry powder is delivered to trough type mixing machine; sucrose is crushed and is delivered in trough type mixing machine after mixed dissolution by pulverizer simultaneously; it is pelletized by oscillating granulator, finally by particle obtained after drying machine is dry and vibration screen-dividing machine screens, pack.
Description
Technical field
This application involves the preparation methods and its preparation of medical production technical field more particularly to a kind of five-medicine tranquilization particle
System.
Background technology
Deficiency of heart and spleen syndrome symptoms include vexed, being irritable and getting angry easily, dry, are easily perspired at palpitaition, sleep dreaming often and waking easily, spiritlessness and weakness,
Loss of appetite, muscle are miserable, can then cause often obtain ortho for a long time, that is, have a sleepless night.
It is mainly shown as sleeping time, depth is insufficient and is unable to dispelling fatigue, regain one's strength and energy, less serious case fall asleep tired
Difficulty or sleep but not soundly, sometimes sleeping and sometimes waking, or cannot sleep again after waking up, it is heavy then be insomnia all night.
Insomnia is one of common clinical disease, though being not belonging to critical illness, interferes people's normal life, work, study
And health, and can aggravate or induce the illnesss such as palpitaition, the obstruction of qi in the chest, dizziness, headache, apoplexy.Intractable aypnia is brought for a long time to patient
Pain, general patient is to alleviate illness, can take hypnotic to help for sleep, finally so that patient grows hypnotic produce
Phase relies on, and pathogenic disease can be caused by taking sleeping drug for a long time.
Invention content
This application provides a kind of preparation methods and its preparation system of five-medicine tranquilization particle, to solve the system of spirit quieting medicine
Standby technical problem.
In order to solve the above-mentioned technical problem, the embodiment of the present application discloses following technical solution：
A kind of preparation method of five-medicine tranquilization particle, includes the following steps：
S01：By treated, wheat, jujube, Gegen tablets and licorice tablet are put into extraction tank respectively, and medicinal material weight is added
8~9 times of water impregnates 40~50min, after immersion, controls the temperature of extractor at 95~100 DEG C, and extraction 120~
125min obtains the first extracting solution, by the first extracting solution by being delivered to storage after extracting the filtering of 80~90 mesh screen of pot bottom
In tank；
S02：In S02, the water of 8~9 times of dregs of a decoction weight is added in the dregs of a decoction after extraction, controls the temperature of extractor 95
~100 DEG C, 120~125min is extracted, obtains the second extracting solution, the second extracting solution is by extracting 80~90 mesh screen mistake of pot bottom
It is delivered in hold-up tank after filter, is mixed with the first extracting solution, obtain the first mixed liquor；
Wheat is also used as Chinese medicine other than it can be used as food, there is treatment to have no peace of mind, have a sleepless night, it is irritated not
Peace and dysthymic effect；Radix Glycyrrhizae can be used for the heart qi deficiency, palpitation and severe palpitation, deficiency of spleen-QI and stomach-QI and lassitude hypodynamia；Contain in jujube
Playing the role of brass~bis- glycosides A has calm, tranquilizing the mind and decompression, and jujube is to tonify deficiency benefit health, nourishing blood and tranquilization, burnout
Powerless, insomnia all has good therapeutic efficiency；The general flavone and Puerarin that pueraria lobata contains can reducing heart rate, reduce heart outside
All drag reduction myocardial oxygen consumptions, can relieving restlessness quench one's thirst, reduce blood pressure.By wheat, jujube, Radix Glycyrrhizae and pueraria lobata together cooking, this
Soup have the effects that it is in sweet flavor nourish, repose and allay excitement and middle emergency, be suitable for absent-minded, diseases such as confusing, insomnia in the heart
Disease.
Since four kinds of wheat, jujube, pueraria lobata and Radix Glycyrrhizae medicinal materials are dry medicinal material, 8 times of amounts are first added before extraction
Use cold water soak so that the cell in these four medicinal materials fully absorbs moisture, then adjusts temperature again and so that cold water temperature is slow
Slow to increase, with gradually rising for water temperature, the cell in medicinal material is slowly burst so that the active ingredient in medicinal material is dissolved completely in
In water.In extraction, after four kinds of medicinal material extracts one time, the first extracting solution after first pass is extracted is delivered in hold-up tank,
It, need to be by the way that the sieve in extraction pot bottom be arranged by the dregs of a decoction mistake in the first extracting solution to avoid containing the dregs of a decoction in the first extracting solution
Filter.
To ensure all to extract the active ingredient in four kinds of medicinal materials, the dregs of a decoction after need to carrying first pass carry again
It takes, then no longer needs to be soaked in water when extracting for the second time, can directly add cold water, control the temperature of extractor, obtain the second extraction
Liquid, the second extracting solution are delivered in hold-up tank by the sieve of extraction pot bottom and are uniformly mixed with the first extracting solution.
S03：First mixed liquor is delivered in concentration tank, by the first mixed liquor be concentrated into relative density be 1.05~
1.10g/cm3Clear cream；
S04：Clear cream is delivered in spray drying tower and is dried and is granulated, obtains medicinal material dry powder, by medicinal material obtained
Dry powder is cooled to room temperature, and is delivered in trough type mixing machine；
S05：Sucrose is ground into the sucrose fine of 80~90 mesh with pulverizer, sucrose fine is delivered to trough type mixing machine
In, with medicinal material dry powder blend；
S06：Ginkgo biloba p.e and dextrin are added sequentially in trough type mixing machine, with medicinal material dry powder and sucrose fine
Trough type mixing machine is opened and is stirred by mixing, and mixing time is 10~15min, and after stirring, 75%~85% ethyl alcohol is added
Then mixing, 5~10min of incorporation time use 16~20 mesh nylon screen of oscillating granulator to pelletize, five-medicine tranquilization particle is made
Wet granular；
Ginkgo leaf has the function of the illnesss such as nervous treatment, hypertension and anxiety in Chinese medicine, will be in ginkgo leaf
Active ingredient extraction after, including lactones and ginkgo brass~glucoside, these active ingredients have powerful inoxidizability with it is clear
Except free radical ability, to protection cardiovascular and cerebrovascular, improvement peripheral blood circulation, cholesterol and treatment the nervous system disease etc. are reduced
Aspect all has apparent effect.Dextrin has the characteristics that sugariness is low, heat is low, dissolubility is good, thickening property is strong, may make last
Five-medicine tranquilization particle obtained is prevented from caking and instant capacity and brew it is good, and the characteristic of original product can be kept, reduce cost,
Product mellow in taste, exquisiteness inhibit the precipitation of crystallization, and the bitter taste in sucrose with ginkgo biloba p.e and pueraria lobata and Radix Glycyrrhizae is added
Taste of traditional Chinese medicine so that product mouthfeel is more preferable.
After medicinal material dry powder, sucrose fine, ginkgo biloba p.e and dextrin are mixed, to make being more uniformly distributed for mixing,
Ethyl alcohol dissolving is added, ethyl alcohol is organic solvent, according to similar compatibility principle, may make the more thorough of the dissolving mixing of organic matter
Bottom is more uniformly distributed, in addition, having stronger volatility by ethyl alcohol, can be volatilized, be dissolved in ethanol after volatilization within a short period of time
Crystal be precipitated, neither influence medicinal material pharmacological property, can also make medicinal material dry powder, sucrose fine, ginkgo biloba p.e and paste
Essence mixing is more uniformly distributed.Finally precipitate is pelletized, obtains wet granular.
S07：Will wet granular suck boiling drier in, control 70~90 DEG C of inlet air temperature, drying time be 100~
140min obtains the dry particl of five-medicine tranquilization particle；
S08：The dry particl of five-medicine tranquilization particle after drying is delivered in vibration screen-dividing machine and is screened, after screening qualification
Particle pack packaging.
After the dry particl of five-medicine tranquilization particle after drying is screened with vibrating screener, granular size is screened unqualified
Be pulverized and mixed again, then be added ethyl alcohol dissolving, drying, granulation, screening process, finally be made qualified products.
Preferably, respectively by the wheat, jujube, pueraria lobata and Radix Glycyrrhizae sort out decontamination, then respectively by the pueraria lobata
With Radix Glycyrrhizae sheet is cut with reciprocating medicine cutter.
Preferably, then respectively pueraria lobata and Radix Glycyrrhizae are cut into sheet with reciprocating medicine cutter, the thickness of the pueraria lobata sheet is 2~
The thickness of 4mm, the Radix Glycyrrhizae sheet are 0.5~2cm.
Slice is one of concocting method of Chinese medicine, and Radix Glycyrrhizae is that quality pine is steeped, viscosity is big, shave is breakable with pueraria lobata
Medicinal material, therefore Radix Glycyrrhizae cuts sheet processing with pueraria lobata.
A kind of preparation system of five-medicine tranquilization particle, system of the preparation method described in claim 1 in five-medicine tranquilization particle
It is carried out in standby system, the preparation system of the five-medicine tranquilization particle includes：Extractor, hold-up tank, concentration tank, spray drying tower,
Trough type mixing machine, pulverizer, oscillating granulator, drying machine and vibration screen-dividing machine, wherein：
The extractor is connected with hold-up tank, and the hold-up tank is connected with concentration tank, and the concentration tank is dry with spraying
Dry tower is connected, and the spray drying tower is connected with trough type mixing machine；
The pulverizer is connected with trough type mixing machine, and the trough type mixing machine is connected with oscillating granulator, described
Oscillating granulator is connected with drying machine, and the drying machine is connected with vibration screen-dividing machine.
It is the embodiment of the present application referring to Fig. 2, Fig. 2 specifically according to the preparation system of the five-medicine tranquilization particle of above-mentioned offer
A kind of preparation system schematic diagram of the five-medicine tranquilization particle provided, the preparation process of five-medicine tranquilization particle are：By sort out impurity elimination
Wheat, jujube, Gegen tablets and the licorice tablet of matter are added in extractor, are extracted to obtain first by the first pass of extractor and are carried
Liquid is taken, the first extracting solution is delivered in hold-up tank, then the dregs of a decoction in extractor are subjected to second time extraction, obtains the second extraction
Second extracting solution is delivered in hold-up tank and is mixed with the first extracting solution by liquid, obtains the first mixed liquor, by the obtain first mixing
Liquid is delivered in concentration tank, adjust 0.05~0.1MPa of steam pressure of concentration tank, vacuum degree be -0.085~-0.075MPa,
Temperature is 75~85 DEG C, and the first mixed liquor is concentrated into 1.05~1.10g/cm3Clear cream after, clear cream is delivered to spray drying
In tower, the steam pressure that adjusts spray drying tower is≤0.6MPa, inlet air temperature be 150~160 DEG C, temperature of outgoing air be 95~
105 DEG C so that the temperature in spray drying tower is maintained at 105~115 DEG C, 10~20MPa of Homogenizing pump, and medicinal material dry powder is made, will
Medicinal material dry powder is delivered in trough type mixing machine, while sucrose being divided into the cane sugar powder of 80 mesh with pulverizer, and cane sugar powder is delivered to
In trough type mixing machine, then ginkgo biloba p.e and dextrin be added into trough type mixing machine, open stirring, mixing time is
10min, the ethanol solution for being then added 75%~85% utilize 16 mesh nylon screen system of oscillating granulator after mixing 5min
Grain, particle obtained are wet granular, and wet granular is sucked in drying machine, is dried, and control inlet air temperature is 70~90 DEG C, is done
The dry time is 100~140min, and finally by the vibration screen-dividing machine screening of the particle after drying, qualified five-medicine tranquilization particle is claimed
Amount pack, underproof five-medicine tranquilization particle are then dissolved with 75%~85% ethanol solution again, then pelletize, is dry,
Qualified five-medicine tranquilization particle is finally weighed pack by sub-sieve.
Preferably, the extractor is provided with discharge nozzle, and one end of the discharge nozzle is connected with the inner cavity of extractor, separately
One end is connected to the inner cavity of the hold-up tank, and is provided with filter screen in the discharge nozzle.
Effective component extracting is added into extractor in wheat, jujube, Gegen tablets and licorice tablet, the extracting solution that will be obtained
It is delivered in hold-up tank after being detached with the dregs of a decoction, needs just to can transport into hold-up tank after filtering extracting solution at this time, in extractor
Filter screen is set in discharge nozzle, when extracting solution enters by discharge nozzle in hold-up tank, extracting solution can be filtered, without in addition
Equipment specially filters extracting solution.
Preferably, the drying machine is provided with discharge port, and the vibration screen-dividing machine is equipped with top sieve and bottom sieve, the top sieve and
The discharge port of drying machine is connected.
Preferably, the sieve diameter of the top sieve is more than the conforming particle of five-medicine tranquilization particle and tiny does not conform to the straight of particle
Diameter, and less than the diameter of the excessively thick unqualified particle of five-medicine tranquilization particle.
Preferably, the sieve diameter of the bottom sieve is less than the diameter of the conforming particle of five-medicine tranquilization coolie, and is more than five
The diameter of the tiny unqualified particle of taste mind easing.
It will be screened by the five-medicine tranquilization particle of drying machine drying, filter out the particle of size qualification, vibrate sub-sieve
Machine is provided with top sieve and bottom sieve, and the five-medicine tranquilization particle after drying enters the top sieve of vibration screen-dividing machine by the discharge port of drying machine
In, the sieve diameter of the top sieve be more than five-medicine tranquilization particle conforming particle and it is tiny do not conform to the diameter of particle, and be less than
The diameter of the excessively thick unqualified particle of five-medicine tranquilization particle, by vibration screening, by the unqualified particle of the excessive five-medicine tranquilization of diameter
It stays in the sieve of top, the too small unqualified particle of qualified five-medicine tranquilization particle and diameter is sieved into bottom sieve, the sieve of the bottom sieve
Bore dia is less than the diameter of the conforming particle of five-medicine tranquilization coolie, and more than the tiny unqualified particle of five-medicine tranquilization particle
Diameter removes the underproof particle of diameter by the vibration screening of bottom sieve, and qualified five-medicine tranquilization particle is stayed in bottom sieve,
Finally the five-medicine tranquilization particle in bottom sieve is packed.
Compared with prior art, the application has the beneficial effect that：
Using wheat, pueraria lobata, jujube, Radix Glycyrrhizae and ginkgo biloba p.e as major ingredient, it is aided with sucrose and dextrin with instant powder
The soaked reference of mode, wheat is also used as Chinese medicine other than it can be used as food, there is treatment to have no peace of mind, have a sleepless night,
Dysphoria and dysthymic effect；Radix Glycyrrhizae can be used for the heart qi deficiency, palpitation and severe palpitation, deficiency of spleen-QI and stomach-QI and lassitude hypodynamia；Greatly
Have the function of calm, tranquilizing the mind and decompression containing the bis- glycoside A of brass-in jujube, and jujube pacifies tonify deficiency benefit health, blood-nourishing
God, lassitude, insomnia all have good therapeutic efficiency；The general flavone and Puerarin that pueraria lobata contains can reducing heart rate, subtract
Few heart peripheral resistance reduces myocardial oxygen consumption, can relieving restlessness quench one's thirst, reduce blood pressure.Together by wheat, jujube, Radix Glycyrrhizae and pueraria lobata
Cooking, this soup have the effects that it is in sweet flavor nourish, repose and allay excitement and middle emergency, be suitable for absent-minded, confusing, sleep in the heart not
The illnesss such as peaceful.Ginkgo leaf has the function of the illnesss such as nervous treatment, hypertension and anxiety in Chinese medicine, will be in ginkgo leaf
Active ingredient extraction after, including lactones and ginkgo brass-glucoside, these active ingredients have powerful inoxidizability and removing
Free radical ability to protection cardiovascular and cerebrovascular, improves the sides such as peripheral blood circulation, reduction cholesterol and treatment the nervous system disease
Face all has apparent effect.Dextrin has the characteristics that sugariness is low, heat is low, dissolubility is good, thickening property is strong, may make last system
Five-medicine tranquilization particle is prevented from caking and instant capacity and brew it is good, and the characteristic of original product can be kept, reduce cost, produce
Product mellow in taste, exquisiteness inhibit the precipitation of crystallization, are added in sucrose and the bitter taste of ginkgo biloba p.e and pueraria lobata and Radix Glycyrrhizae
Taste of traditional Chinese medicine so that product mouthfeel is more preferable.
The preparation system for taking five-medicine tranquilization particle provided by the invention, by the wheat, jujube, pueraria lobata of sort out decontamination
Piece and licorice tablet are added in extractor, are carried wheat, jujube, Gegen tablets and licorice tablet twice by extractor
It takes, extraction twice can more extract the middle active ingredient of wheat, jujube, Gegen tablets and licorice tablet, will carry twice
The extracting solution obtained is mixed to get the first mixed liquor, and the first obtained mixed liquor is delivered in concentration tank, by the first mixing
Liquid is concentrated into 1.05~1.10g/cm3Clear cream after, clear cream is delivered in spray drying tower, medicinal material dry powder is made, by medicinal material
Dry powder is delivered in trough type mixing machine, while sucrose being crushed with pulverizer, and cane sugar powder is delivered in trough type mixing machine, then will
Ginkgo biloba p.e and dextrin are added into trough type mixing machine, open after then ethanol solution mixing is added in stirring, using waving
Formula granulator is pelletized, and particle obtained is wet granular, and wet granular is sucked in drying machine, is dried, finally will be after drying
Particle vibration screen-dividing machine screening, weighs pack, underproof five-medicine tranquilization particle is then by qualified five-medicine tranquilization particle
It is dissolved again with ethanol solution, then pelletizes, dry, sub-sieve, qualified five-medicine tranquilization particle is finally weighed into pack, will be given birth to
The production underproof product of granular size re-dissolves, and then pelletizes, dry, sub-sieve, avoids increasing cost to the waste of raw material.
It should be understood that above general description and following detailed description is only exemplary and explanatory, not
The application can be limited.
Description of the drawings
In order to illustrate more clearly of the technical solution of the application, letter will be made to attached drawing needed in the embodiment below
Singly introduce, it should be apparent that, for those of ordinary skills, without creative efforts, also
It can be obtain other attached drawings according to these attached drawings.
Fig. 1 is a kind of method flow diagram of the preparation method of five-medicine tranquilization particle provided by the embodiments of the present application；
Fig. 2 is a kind of schematic diagram of the preparation system of five-medicine tranquilization particle provided by the embodiments of the present application.
Specific implementation mode
In order to make those skilled in the art better understand the technical solutions in the application, below in conjunction with the application reality
The attached drawing in example is applied, technical solutions in the embodiments of the present application is clearly and completely described, it is clear that described implementation
Example is only some embodiments of the present application, rather than whole embodiments.Based on the embodiment in the application, the common skill in this field
The every other embodiment that art personnel are obtained without making creative work should all belong to the application protection
Range.
Referring to FIG. 1, showing a kind of method stream of the preparation method of five-medicine tranquilization particle provided by the embodiments of the present application
Cheng Tu, following embodiment is based on process step shown in FIG. 1.As seen from Figure 1, this method includes the following steps：
S01：By treated, wheat, jujube, Gegen tablets and licorice tablet are put into extraction tank respectively, and medicinal material weight is added
8~9 times of water impregnates 40~50min, after immersion, controls the temperature of extractor at 95~100 DEG C, and extraction 120~
125min obtains the first extracting solution, by the first extracting solution by being delivered to storage after extracting the filtering of 80~90 mesh screen of pot bottom
In tank；
S02：In S02, the water of 8~9 times of dregs of a decoction weight is added in the dregs of a decoction after extraction, controls the temperature of extractor 95
~100 DEG C, 120~125min is extracted, obtains the second extracting solution, the second extracting solution is by extracting 80~90 mesh screen mistake of pot bottom
It is delivered in hold-up tank after filter, is mixed with the first extracting solution, obtain the first mixed liquor；
S03：First mixed liquor is delivered in concentration tank, by the first mixed liquor be concentrated into relative density be 1.05~
1.10g/cm3Clear cream；
S04：Clear cream is delivered in spray drying tower and is dried and is granulated, obtains medicinal material dry powder, by medicinal material obtained
Dry powder is cooled to room temperature, and is delivered in trough type mixing machine；
S05：Sucrose is ground into the sucrose fine of 80~90 mesh with pulverizer, sucrose fine is delivered to trough type mixing machine
In, with medicinal material dry powder blend；
S06：Ginkgo biloba p.e and dextrin are added sequentially in trough type mixing machine, with medicinal material dry powder and sucrose fine
Trough type mixing machine is opened and is stirred by mixing, and mixing time is 10~15min, and after stirring, 75%~85% ethyl alcohol is added
Then mixing, 5~10min of incorporation time use 16~20 mesh nylon screen of oscillating granulator to pelletize, five-medicine tranquilization particle is made
Wet granular；
S07：Will wet granular suck boiling drier in, control 70~90 DEG C of inlet air temperature, drying time be 100~
140min obtains the dry particl of five-medicine tranquilization particle；
S08：The dry particl of five-medicine tranquilization particle after drying is delivered in vibration screen-dividing machine and is screened, after screening qualification
Particle pack packaging.
Embodiment 1
S101：By treated, wheat, jujube, Gegen tablets and licorice tablet are put into extraction tank respectively, and medicinal material weight is added
The water of 8 times of amount impregnates 40min, after immersion, controls the temperature of extractor at 95 DEG C, extracts 120min, obtain the first extraction
Liquid, by the first extracting solution by being delivered in hold-up tank after extracting the filtering of 80 mesh screen of pot bottom；
S102：In S02, the water of 8 times of dregs of a decoction weight is added in the dregs of a decoction after extraction, controls the temperature of extractor 95
DEG C, 120min is extracted, obtains the second extracting solution, the second extracting solution after extracting the filtering of 80 mesh screen of pot bottom by being delivered to storage
It in tank, is mixed with the first extracting solution, obtains the first mixed liquor；
S103：First mixed liquor is delivered in concentration tank, it is 1.05g/cm that the first mixed liquor, which is concentrated into relative density,3
Clear cream；
S104：Clear cream is delivered in spray drying tower and is dried and is granulated, obtains medicinal material dry powder, by medicinal material obtained
Dry powder is cooled to room temperature, and is delivered in trough type mixing machine；
S105：Sucrose is ground into the sucrose fine of 80 mesh with pulverizer, sucrose fine is delivered in trough type mixing machine,
With medicinal material dry powder blend；
S106：Ginkgo biloba p.e and dextrin are added sequentially in trough type mixing machine, it is thin with medicinal material dry powder and sucrose
Powder mixes, and trough type mixing machine is opened and is stirred, mixing time 10min, after stirring, 75% ethyl alcohol mixing is added, mixes
Time 5min is closed, then 16 mesh nylon screen of oscillating granulator is used to pelletize, the wet granular of five-medicine tranquilization particle is made；
S107：Wet granular is sucked in boiling drier, 70 DEG C, drying time 100min of inlet air temperature is controlled, is obtained
The dry particl of five-medicine tranquilization particle；
S108：The dry particl of five-medicine tranquilization particle after drying is delivered in vibration screen-dividing machine and is screened, screening is qualified
Particle pack packaging afterwards.
Embodiment 2
S201：By treated, wheat, jujube, Gegen tablets and licorice tablet are put into extraction tank respectively, and medicinal material weight is added
The water of 9 times of amount impregnates 50min, after immersion, controls the temperature of extractor at 100 DEG C, extracts 125min, obtain first and carry
Liquid is taken, by the first extracting solution by being delivered in hold-up tank after extracting the filtering of 90 mesh screen of pot bottom；
S202：In S02, the water of 9 times of dregs of a decoction weight is added in the dregs of a decoction after extraction, controls the temperature of extractor 100
DEG C, 125min is extracted, obtains the second extracting solution, the second extracting solution after extracting the filtering of 90 mesh screen of pot bottom by being delivered to storage
It in tank, is mixed with the first extracting solution, obtains the first mixed liquor；
S203：First mixed liquor is delivered in concentration tank, it is 1.10g/cm that the first mixed liquor, which is concentrated into relative density,3
Clear cream；
S204：Clear cream is delivered in spray drying tower and is dried and is granulated, obtains medicinal material dry powder, by medicinal material obtained
Dry powder is cooled to room temperature, and is delivered in trough type mixing machine；
S205：Sucrose is ground into the sucrose fine of 90 mesh with pulverizer, sucrose fine is delivered in trough type mixing machine,
With medicinal material dry powder blend；
S206：Ginkgo biloba p.e and dextrin are added sequentially in trough type mixing machine, it is thin with medicinal material dry powder and sucrose
Powder mixes, and trough type mixing machine is opened and is stirred, mixing time 15min, after stirring, 85% ethyl alcohol mixing is added, mixes
Time 10min is closed, then 20 mesh nylon screen of oscillating granulator is used to pelletize, the wet granular of five-medicine tranquilization particle is made；
S207：Wet granular is sucked in boiling drier, 90 DEG C, drying time 140min of inlet air temperature is controlled, is obtained
The dry particl of five-medicine tranquilization particle；
S208：The dry particl of five-medicine tranquilization particle after drying is delivered in vibration screen-dividing machine and is screened, screening is qualified
Particle pack packaging afterwards.
A kind of preparation system of five-medicine tranquilization particle, system of the preparation method described in claim 1 in five-medicine tranquilization particle
It is carried out in standby system, the preparation system of the five-medicine tranquilization particle includes：Extractor 1, hold-up tank 2, concentration tank 3, spray drying
Tower 4, trough type mixing machine 5, pulverizer 6, oscillating granulator 7, drying machine 8 and vibration screen-dividing machine 9, wherein：
The extractor 1 is connected with hold-up tank 2, and the hold-up tank 2 is connected with concentration tank 3, the concentration tank 3 and spray
Mist drying tower 4 is connected, and the spray drying tower 4 is connected with trough type mixing machine 5；
The pulverizer 6 is connected with trough type mixing machine 5, and the trough type mixing machine 5 is connected with oscillating granulator 7,
The oscillating granulator 7 is connected with drying machine 8, and the drying machine 8 is connected with vibration screen-dividing machine 9.
It is the embodiment of the present application referring to Fig. 2, Fig. 2 specifically according to the preparation system of the five-medicine tranquilization particle of above-mentioned offer
A kind of preparation system schematic diagram of the five-medicine tranquilization particle provided, the preparation process of five-medicine tranquilization particle are：By sort out impurity elimination
Wheat, jujube, Gegen tablets and the licorice tablet of matter are added in extractor 1, extract to obtain first by the first pass of extractor 1
First extracting solution is delivered in hold-up tank 2 by extracting solution, then the dregs of a decoction in extractor 1 are carried out second time extraction, obtains second
Second extracting solution is delivered in hold-up tank 2 and is mixed with the first extracting solution by extracting solution, obtains the first mixed liquor, will obtained
One mixed liquor is delivered in concentration tank 3, adjust 0.05~0.1MPa of steam pressure of concentration tank 3, vacuum degree be -0.085~-
0.075MPa, temperature are 75~85 DEG C, and the first mixed liquor is concentrated into 1.05~1.10g/cm3Clear cream after, clear cream is conveyed
Into spray drying tower 4, the steam pressure of adjustment spray drying tower 4 is≤0.6MPa, inlet air temperature be 150~160 DEG C, air draft
Temperature is 95~105 DEG C so that the temperature in spray drying tower 4 is maintained at 105~115 DEG C, 10~20MPa of Homogenizing pump, is made
Medicinal material dry powder is delivered in trough type mixing machine 5 by medicinal material dry powder, while sucrose pulverizer 6 being divided into the cane sugar powder of 80 mesh, will
Cane sugar powder is delivered in trough type mixing machine 5, then ginkgo biloba p.e and dextrin are added into trough type mixing machine 5, opens stirring,
Mixing time is 10min, and the ethanol solution for being then added 75%~85% utilizes in oscillating granulator 7 16 after mixing 5min
Mesh nylon screen is pelletized, and particle obtained is wet granular, and wet granular is sucked in drying machine 8, is dried, and controls inlet air temperature
It it is 70~90 DEG C, drying time is 100~140min, is finally screened the particle vibration screen-dividing machine 9 after drying, by qualification
Five-medicine tranquilization particle weighs pack, and underproof five-medicine tranquilization particle is then dissolved with 75%~85% ethanol solution again,
Then it pelletizes, dry, sub-sieve, qualified five-medicine tranquilization particle is finally weighed into pack.
Since embodiment of above is that reference combination illustrates on other modes, have between different embodiments
There is an identical part, just to refer each other for identical, similar part between each embodiment in this specification.Herein no longer in detail
It illustrates.
It should be noted that in the present specification, the terms "include", "comprise" or its any other variant are intended to
Non-exclusive inclusion so that article or equipment including a series of elements include not only those elements, but also is wrapped
Other elements that are not explicitly listed are included, or further include for this article or the intrinsic element of equipment.Do not having more
In the case of more limitations, there is the element that sentence "including a ..." limits, it is not excluded that including the element article or
There is also other identical elements in person's equipment.
Those skilled in the art will readily occur to its of the application after considering specification and putting into practice the disclosure invented here
His embodiment.This application is intended to cover the present invention any variations, uses, or adaptations, these modifications, purposes or
Person's adaptive change follows the general principle of the application and includes the undocumented common knowledge in the art of the application
Or conventional techniques.The description and examples are only to be considered as illustrative, and the true scope and spirit of the application are wanted by right
The content asked is pointed out.
Above-described the application embodiment does not constitute the restriction to the application protection domain.
Claims (8)
1. a kind of preparation method of five-medicine tranquilization particle, which is characterized in that include the following steps：
S01：By treated, wheat, jujube, Gegen tablets and licorice tablet are put into extraction tank respectively, and medicinal material weight 8~9 is added
Water again impregnates 40~50min, after immersion, controls the temperature of extractor at 95~100 DEG C, extracts 120~125min,
The first extracting solution is obtained, by the first extracting solution by being delivered in hold-up tank after extracting the filtering of 80~90 mesh screen of pot bottom；
S02：In S02, the water of 8~9 times of dregs of a decoction weight is added in the dregs of a decoction after extraction, control the temperature of extractor 95~
100 DEG C, 120~125min is extracted, the second extracting solution is obtained, by the second extracting solution by extracting 80~90 mesh screen mistake of pot bottom
It is delivered in hold-up tank after filter, is mixed with the first extracting solution, obtain the first mixed liquor；
S03：First mixed liquor is delivered in concentration tank, it is 1.05~1.10g/cm that the first mixed liquor, which is concentrated into relative density,3
Clear cream；
S04：Clear cream is delivered in spray drying tower and is dried and is granulated, obtains medicinal material dry powder, by medicinal material dry powder obtained
It is cooled to room temperature, and is delivered in trough type mixing machine；
S05：Sucrose is ground into the sucrose fine of 80~90 mesh with pulverizer, sucrose fine is delivered in trough type mixing machine,
With medicinal material dry powder blend；
S06：Ginkgo biloba p.e and dextrin are added sequentially in trough type mixing machine, it is mixed with medicinal material dry powder and sucrose fine
It closes, trough type mixing machine is opened and is stirred, mixing time is 10~15min, and after stirring, the ethyl alcohol of addition 75%~85% is mixed
It closes, 5~10min of incorporation time, then 16~20 mesh nylon screen of oscillating granulator is used to pelletize, five-medicine tranquilization particle is made
Wet granular；
S07：Wet granular is sucked in boiling drier, 70~90 DEG C of inlet air temperature is controlled, drying time is 100~140min,
Obtain the dry particl of five-medicine tranquilization particle；
S08：The dry particl of five-medicine tranquilization particle after drying is delivered in vibration screen-dividing machine and is screened, by of the screening after qualified
Grain pack packaging.
2. the preparation method of five-medicine tranquilization particle according to claim 1, which is characterized in that respectively by the wheat, big
Jujube, pueraria lobata and Radix Glycyrrhizae sort out decontamination, then the pueraria lobata and Radix Glycyrrhizae are cut into sheet with reciprocating medicine cutter respectively.
3. the preparation method of five-medicine tranquilization particle according to claim 2, which is characterized in that again respectively by pueraria lobata and Radix Glycyrrhizae
Sheet is cut with reciprocating medicine cutter, the thickness of the pueraria lobata sheet is 2~4mm, and the thickness of the Radix Glycyrrhizae sheet is 0.5~2cm.
4. a kind of preparation system of five-medicine tranquilization particle, which is characterized in that the preparation system of the five-medicine tranquilization particle includes：It carries
Take tank (1), hold-up tank (2), concentration tank (3), spray drying tower (4), trough type mixing machine (5), pulverizer (6), swing particle
Machine (7), drying machine (8) and vibration screen-dividing machine (9), wherein：
The extractor (1) is connected with hold-up tank (2), and the hold-up tank (2) is connected with concentration tank (3), the concentration tank
(3) it is connected with spray drying tower (4), the spray drying tower (4) is connected with trough type mixing machine (5)；
The pulverizer (6) is connected with trough type mixing machine (5), and the trough type mixing machine (5) is connected with oscillating granulator (7)
Logical, the oscillating granulator (7) is connected with drying machine (8), and the drying machine (8) is connected with vibration screen-dividing machine (9).
5. the preparation system of five-medicine tranquilization particle according to claim 4, which is characterized in that extractor (1) setting
There are discharge nozzle, one end of the discharge nozzle to be connected with the inner cavity of the extractor (1), the other end and the hold-up tank (2)
Inner cavity is connected to, and is provided with filter screen in the discharge nozzle.
6. the preparation system of five-medicine tranquilization particle according to claim 4, which is characterized in that drying machine (8) setting
There are discharge port, the vibration screen-dividing machine (9) to be equipped with top sieve and bottom sieve, the discharge port phase of the top sieve and oscillating granulator (7)
Connection.
7. the preparation system of five-medicine tranquilization particle according to claim 6, which is characterized in that the sieve diameter of the top sieve
More than the conforming particle of five-medicine tranquilization particle and the tiny diameter for not conforming to particle, and it is excessively thick unqualified less than five-medicine tranquilization particle
The diameter of particle.
8. the preparation system of five-medicine tranquilization particle according to claim 6, which is characterized in that the sieve diameter of the bottom sieve
Less than the diameter of the conforming particle of five-medicine tranquilization coolie, and the diameter of the tiny unqualified particle more than five-medicine tranquilization particle.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110292597A (en) * | 2019-05-28 | 2019-10-01 | 海南海力制药有限公司 | A kind of Chinese medicinal granule that treating children's dyspneic cough and preparation method |
| CN115581724A (en) * | 2022-10-20 | 2023-01-10 | 广州百奥格林生物科技有限公司 | Preparation method and system of traditional Chinese medicine compound preparation for treating rheumatoid arthritis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110292597A (en) * | 2019-05-28 | 2019-10-01 | 海南海力制药有限公司 | A kind of Chinese medicinal granule that treating children's dyspneic cough and preparation method |
| CN115581724A (en) * | 2022-10-20 | 2023-01-10 | 广州百奥格林生物科技有限公司 | Preparation method and system of traditional Chinese medicine compound preparation for treating rheumatoid arthritis |
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Application publication date: 20180828 |