CN106540233A - A kind of preparation method of tangerine peel bamboo shavings granule - Google Patents
A kind of preparation method of tangerine peel bamboo shavings granule Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The present invention relates to the preparation method of tangerine peel bamboo shavings granule，Can effectively solving take、Carry inconvenient，Affect using the problem with curative effect，Method is，By 700 730g of Pericarpium Citri Reticulatae、700 730g of Caulis Bambusae In Taenia、270 300g of Radix Glycyrrhizae、135 155g of Radix Ginseng、410 450g of Rhizoma Zingiberis Recenss、560 640g of Fructus Jujubae and adjuvant Lactose、Beta cyclodextrin is made，By Pericarpium Citri Reticulatae、Caulis Bambusae In Taenia、Radix Glycyrrhizae、Radix Ginseng、Rhizoma Zingiberis Recenss and Fructus Jujubae are mixed，Add water to cook twice，Decocting liquid is filtered，Filtrate is concentrated into the clear paste that 80 DEG C of relative densities are 1.10～1.15，It is spray dried to fine powder，Lactose is added in fine powder、Beta cyclodextrin is to 1000g，Compacting granulating，Abundant raw material of the present invention，It is prepared by easily production，Both decoction effect had been maintained rapid，The advantage of markedly fast，Overcome the shortcoming that inconvenience is decocted when decoction is taken simultaneously again，Gained better stability of preparation，Take、Carry、Storage and convenient transportation.
Description
Technical field
The present invention relates to medical, particularly a kind of preparation method of tangerine peel bamboo shavings granule.
Background technology
Tangerine Peel and Bamboo Shavings Decoction faces card and can be used to treat vomiting during pregnancy, the obstruction of pylorus imperfection, diaphragm spasm and postoperative singultuss
The category insufficiency of stomach such as more than has hot person.But decoction decocting inconvenience, bitter in the mouth amount are big, are difficult to be accepted, and affect using effect and curative effect, because
This develops taking convenience, and portable novel form is the technical problem that must be solved.
The content of the invention
For above-mentioned situation, the purpose to overcome the defect of prior art, the present invention is just to provide a kind of tangerine peel bamboo shavings
The preparation method of grain, can effectively solving take, carry inconvenience, affect the problem of use and curative effect.
The technical scheme that the present invention is solved is that the granule is by material medicine Pericarpium Citri Reticulatae 700-730g, the Caulis Bambusae In Taenia of weight meter
700-730g, Radix Glycyrrhizae 270-300g, Radix Ginseng 135-155g, Rhizoma Zingiberis Recenss 410-450g, Fructus Jujubae 560-640g and adjuvant Lactose, β-ring paste
It is refined into, Pericarpium Citri Reticulatae, Caulis Bambusae In Taenia, Radix Glycyrrhizae, Radix Ginseng, Rhizoma Zingiberis Recenss and Fructus Jujubae is mixed, add water to cook twice, adds crude drug for the first time
The water that 8 times of thing weight, decocts 1.5h, adds the water of 6 times of material medicine weight for the second time, decoct 1h, merge decocting liquid twice, mistake
Filter, filtrate are concentrated into the clear paste that 80 DEG C of relative densities are 1.10～1.15, are spray dried to fine powder, add in fine powder Lactose, β-
Cyclodextrin suppresses granulating to 1000g, Lactose, the weight ratio of beta-schardinger dextrin-are 22-44 ︰ 45-47.
Prepared by abundant raw material of the present invention, easily production, both maintained decoction effect rapidly, the advantage of markedly fast, while and gram
The shortcoming that inconvenience is decocted when decoction is taken is taken, gained better stability of preparation is taken, carries, preserving and convenient transportation, is Chinese medicine
Innovation in preparation, has notable economic and social benefit.
Description of the drawings
Fig. 1 is the process chart of the present invention.
Specific embodiment
The specific embodiment of the present invention is elaborated below in conjunction with drawings and Examples.
The present invention can be given by following examples in being embodied as.
Embodiment 1
The present invention in being embodied as, by the material medicine Pericarpium Citri Reticulatae 715g of weight meter, Caulis Bambusae In Taenia 715g, Radix Glycyrrhizae 285g, Radix Ginseng
145g, Rhizoma Zingiberis Recenss 430g, Fructus Jujubae 595g and adjuvant Lactose, beta-schardinger dextrin-are made, by Pericarpium Citri Reticulatae, Caulis Bambusae In Taenia, Radix Glycyrrhizae, Radix Ginseng, Rhizoma Zingiberis Recenss and big
Fructus Jujubae is mixed, and is added water to cook twice, adds the water of 8 times of material medicine weight for the first time, decocts 1.5h, second addition raw material
The water that 6 times of drug weight, decocts 1h, merges decocting liquid twice, filters, and it is 1.10～1.15 that filtrate is concentrated into 80 DEG C of relative densities
Clear paste, is spray dried to fine powder, adds Lactose, beta-schardinger dextrin-to 1000g, suppress granulating in fine powder, Lactose, β-ring paste
The weight ratio of essence is 22-44 ︰ 45-47.
Embodiment 2
The present invention in being embodied as, by the material medicine Pericarpium Citri Reticulatae 710g of weight meter, Caulis Bambusae In Taenia 720g, Radix Glycyrrhizae 275g, Radix Ginseng
150g, Rhizoma Zingiberis Recenss 415g, Fructus Jujubae 635g and adjuvant Lactose, beta-schardinger dextrin-are made, by Pericarpium Citri Reticulatae, Caulis Bambusae In Taenia, Radix Glycyrrhizae, Radix Ginseng, Rhizoma Zingiberis Recenss and big
Fructus Jujubae is mixed, and is added water to cook twice, adds the water of 8 times of material medicine weight for the first time, decocts 1.5h, second addition raw material
The water that 6 times of drug weight, decocts 1h, merges decocting liquid twice, filters, and it is 1.10～1.15 that filtrate is concentrated into 80 DEG C of relative densities
Clear paste, is spray dried to fine powder, adds Lactose, beta-schardinger dextrin-to 1000g, suppress granulating in fine powder, Lactose, β-ring paste
The weight ratio of essence is 22-44 ︰ 45-47.
Embodiment 3
The present invention in being embodied as, by the material medicine Pericarpium Citri Reticulatae 720g of weight meter, Caulis Bambusae In Taenia 710g, Radix Glycyrrhizae 295g, Radix Ginseng
140g, Rhizoma Zingiberis Recenss 445g, Fructus Jujubae 565g and adjuvant Lactose, beta-schardinger dextrin-are made, by Pericarpium Citri Reticulatae, Caulis Bambusae In Taenia, Radix Glycyrrhizae, Radix Ginseng, Rhizoma Zingiberis Recenss and big
Fructus Jujubae is mixed, and is added water to cook twice, adds the water of 8 times of material medicine weight for the first time, decocts 1.5h, second addition raw material
The water that 6 times of drug weight, decocts 1h, merges decocting liquid twice, filters, and it is 1.10～1.15 that filtrate is concentrated into 80 DEG C of relative densities
Clear paste, is spray dried to fine powder, adds Lactose, beta-schardinger dextrin-to 1000g, suppress granulating in fine powder, Lactose, β-ring paste
The weight ratio of essence is 22-44 ︰ 45-47.
In said medicine, wherein：
1. Pericarpium Citri Reticulatae：This product is being dried to for rutaceae orange Citrus reticulata Blanco and its variety
Ripe peel.Medical material is divided into " Pericarpium Citri Reticulatae " and " Pericarpium citri reticuatae chachiensiss ".Harvesting ripe fruit, strips peel, dries or cold drying.Should meet
《Chinese Pharmacopoeia》Specify under the Pericarpium Citri Reticulatae items of page 191 in version in 2015.
2. Caulis Bambusae In Taenia：This product is grass bambusa breviflora Munro Barnbusa tuldoides Muniro, major part allusion quotation bamboo
Sinocalamus beecheyanus (M u n r o) McClure var.pubescens P.F.Li or phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle
PhylLostachys nigra Chodd.) Munro var.henonis (Mitf.) Stapf ex Rendle stalk it is dry
Dry intermediate layer.Whole year can gather and process, and take fresh stem, remove crust, slightly viridant intermediate layer is spread to strand, or is whittled into thin
Piece, ties up bunchy, dries in the shade.The former claims " scattered Caulis Bambusae In Taenia ", and the latter claims " neat Caulis Bambusae In Taenia ".Should meet《Chinese Pharmacopoeia》In version in 2015
Regulation under the Caulis Bambusae In Taenia items of page 139.
3. Radix Ginseng：This product is Araliaceae Radix Ginseng Pana:The dry root and rhizome of c ginseng C.A.Mey..It is more than
Autumn excavates, and clean Jing is dried or dried.That what is cultivated is commonly called as " Park Ginseng "；The title that sowing is grown under mountain forest wild state naturally
" ginseng under forest ", practises and claims " seed sea ".Should meet《Chinese Pharmacopoeia》Specify under the Radix Ginseng items of page 8 in version in 2015.
4. Radix Glycyrrhizae：This product is glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat.
The dry root and rhizome of Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..Spring, autumn two
Season excavates, and removes fibrous root, dries.Should meet《Chinese Pharmacopoeia》Specify under the Radix Glycyrrhizae items of page 86 in version in 2015.
5. Rhizoma Zingiberis Recenss：New fresh quench stem of this product for zingiber Zingiber officinale Rose..Autumn, two season of winter
Excavation, removes fibrous root and silt.Impurity is removed, is cleaned, the used time cuts sheet.Should meet《Chinese Pharmacopoeia》In version in 2015
Specify under the Rhizoma Zingiberis Recenss items of page 101.
6. Fructus Jujubae：Dry mature fruit of this product for Rhamnaceae Yi thing Fructus Jujubae Ziziphus jujuba Mill..Autumn fruit
Harvest when ripe, dry.Impurity is removed, is cleaned, is dried.Used time breaks or enucleation.Should meet《Chinese Pharmacopoeia》Version one in 2015
Specify under the Fructus Jujubae items of page 22 in portion.
Granular preparation of the present invention effective for treat vomiting during pregnancy, pylorus imperfection obstruction, diaphragm spasm and it is postoperative oh
There is hot person against the category insufficiency of stomach such as more than, be that applicant's Jing scientific researches, test and the creative work made to practice summary are crystallized,
Relevant testing data is as follows：
1st, the test of group component
The modern consumption being expressly recited is analyzed using SPSS19.0 statistical softwares, using mean, percentile, extreme difference etc.
Carry out statistics description to the consumption in Tangerine Peel and Bamboo Shavings Decoction composition per taste medicine, and with version in 2010《Chinese Pharmacopoeia》Specified in dosage
Make relative analyses.As a result it is as follows：
Per taste survival dose general evaluation system result in Tangerine Peel and Bamboo Shavings Decoction composition
Per taste pharmaceutical quantities frequency statistics result in Tangerine Peel and Bamboo Shavings Decoction composition
Pericarpium Citri tangerinae minimum amount 9.0g is can be seen that from data collection statistical result, research on maximum utilized quantity 48.0g, applying frequency is most
Multiple dose 12.0g, accounts for overall amount ratio 50.0%, Pericarpium Citri tangerinae mean dose 18.0g,《Chinese Pharmacopoeia》2010 editions ormal weights 3～
10g.It is comprehensive《Chinese Pharmacopoeia》Dosage and usual dose range, Pericarpium Citri tangerinae consumption 12.0g.
Caulis Bambusae In Taenia minimum amount 9.0g, research on maximum utilized quantity 48.0g, the most dosage 12.0g of applying frequency, accounts for overall amount ratio
50.0%, Caulis Bambusae In Taenia mean dose 9.2g,《Chinese Pharmacopoeia》2010 editions 5～10g of ormal weight.It is comprehensive《Chinese Pharmacopoeia》Dosage and conventional
Amount scope, Caulis Bambusae In Taenia consumption 12.0g.
Fructus Jujubae minimum amount 5.0g, research on maximum utilized quantity 30.0g, the most dosage 5.0g of applying frequency, accounts for overall amount ratio
83.3%, Fructus Jujubae mean dose 9.2g, also have modern age doctor to refer to original side's ratio, it is believed that the modern age consumption of Fructus Jujubae is 5 pieces.《In
State's pharmacopeia》2010 editions 6～15g of ormal weight.It is comprehensive《Chinese Pharmacopoeia》Dosage and usual dose range, 5 pieces (per piece of Fructus Jujubae consumption
2.5g)。
Rhizoma Zingiberis Recenss minimum amount 9.0g, research on maximum utilized quantity 24.0g, the most dosage 9.0g of applying frequency, accounts for overall amount ratio
66.7%, Rhizoma Zingiberis Recenss mean dose 12.0g,《Chinese Pharmacopoeia》2010 editions 3～10g of ormal weight.It is comprehensive《Chinese Pharmacopoeia》It is dosage, conventional
Amount scope and original side's proportionate relationship, Rhizoma Zingiberis Recenss consumption 9g.
Radix Glycyrrhizae minimum amount 5.0g, research on maximum utilized quantity 15.0g, the most dosage 6.0g of applying frequency, accounts for overall amount ratio
66.7%, Radix Glycyrrhizae mean dose 7.3g,《Chinese Pharmacopoeia》2010 editions 2～10g of ormal weight.It is comprehensive《Chinese Pharmacopoeia》Dosage and conventional
Amount scope, Radix Glycyrrhizae consumption 6g.
Radix Ginseng minimum amount 1.5g, research on maximum utilized quantity 5.0g, the most dosage 3.0g of applying frequency, accounts for overall amount ratio
83.3%, Radix Ginseng mean dose 3.3g,《Chinese Pharmacopoeia》2010 editions 3～9g of ormal weight.It is comprehensive《Chinese Pharmacopoeia》Dosage and conventional
Amount scope, Radix Ginseng consumption 3g.
Tangerine Peel and Bamboo Shavings Decoction drug dose Tangerine Peel and Bamboo Shavings Decoction drug dose《Medical Treasures of the Golden Chamber》It is described below：Two liters of Pericarpium Citri tangerinae, Caulis Bambusae In Taenia
Two liters, Radix Ginseng one or two, half jin of Rhizoma Zingiberis Recenss, 30 pieces of Fructus Jujubae, five liang of Radix Glycyrrhizae.Change excessive when Tangerine Peel and Bamboo Shavings Decoction dosage later age is used,
In side, the amount of Pericarpium Citri tangerinae has two liters, one liter, two jin, one jin, a change of five kinds of two money, the amount of Caulis Bambusae In Taenia then have two liters, one and half, one liter,
Two money, a money, six kinds of changes of a fritter, Radix Ginseng have three liang, one or two, half two, one money, five points of five Dose standards, and Rhizoma Zingiberis Recenss have half
Jin, eight liang, half two, two money, eight points, five six Dose standards, Radix Glycyrrhizae have five liang, two liang, half two, five money, a money, five point six
Individual Dose standard, generally speaking, party's later age changes with and differ larger between more and each dosage.Pericarpium Citri tangerinae original side amount two in side
Rise, the useful two jin of persons of later age have research to be considered mistranscription, and " jin " is writing by mistake for " liter ".Then one is converted according to volumetric(al) standardss
Rising amount has a various criterion of 60-80ml, 198ml, 200ml, later age with when two liters also have tetra- dosage of 48g, 12g, 15g, 9g,
So there is bigger difference in the calculating of the amount of Pericarpium Citri tangerinae and Caulis Bambusae In Taenia, modern medication custom, institute are not met if being unit by ml
Edited with reference to super Deng Zhongjia with the consumption of this two tastes medicine《The pharmacology of Chinese medical formulae》Consumption 15g and clinical practice situation, Pericarpium Citri tangerinae and Caulis Bambusae In Taenia amount are
15g.By dosage conversions and statistical analysiss, in finally drawing successive dynasties document, Fructus Jujubae usual dose range is 5.0～75.0g, comprehensive
Fructus Jujubae mean dose 57.1g and《Chinese Pharmacopoeia》2010 editions 6～15g of ormal weight, 5 pieces of Fructus Jujubae consumption.Rhizoma Zingiberis Recenss usual dose range exists
9.0～24.0g, comprehensive Rhizoma Zingiberis Recenss mean dose 12.0g and《Chinese Pharmacopoeia》2010 editions 3～10g of ormal weight, Rhizoma Zingiberis Recenss consumption 9g.It is sweet
Careless usual dose range in 5.3～15.0g, comprehensive Radix Glycyrrhizae mean dose 7.3g and《Chinese Pharmacopoeia》2010 editions 2～10g of ormal weight,
Radix Glycyrrhizae consumption 6g.Radix Ginseng usual dose range in 1.5～3g, comprehensive Radix Ginseng mean dose 3.3g and《Chinese Pharmacopoeia》2010 editions regulations
Amount 3～9g, Radix Ginseng consumption 3g.
It is as follows by above statistical result and quantity tangerine peel bamboo shavings granule dosage：
Pericarpium Citri tangerinae 15g, Caulis Bambusae In Taenia 15g, Radix Ginseng 3g, Rhizoma Zingiberis Recenss 9g, Radix Glycyrrhizae 6g, 5 pieces of Fructus Jujubae (every piece of 2.5g), in batch production,
Using Pericarpium Citri Reticulatae 700-730g, Caulis Bambusae In Taenia 700-730g, Radix Glycyrrhizae 270-300g, Radix Ginseng 135-155g, Rhizoma Zingiberis Recenss 410-450g, Fructus Jujubae 560-
640g and adjuvant Lactose, beta-schardinger dextrin-are made, and Lactose, the weight ratio of beta-schardinger dextrin-are 22-44 ︰ 45-47.
2nd, the test of extraction conditions
Chinese medicine classical prescription granule is on the basis of Chinese medical theory is followed, the characteristics of preparation according to traditional decoction, in principle
Be requirement water be that solvent carries out heating extraction.This test keeps solvent constant, using the method for orthogonal test, to water extraction work
Skill is investigated.
(1) decoction pieces water absorption rate is investigated
Plant decoction pieces have the ability of different degrees of absorption solvent, and the size for absorbing solvent amount will affect extraction effect.
Therefore, decoction pieces have been carried out with the measure of water absorption rate.
Weigh 3 portions of decoction pieces (i.e. Pericarpium Citri Reticulatae 30g, Caulis Bambusae In Taenia 30g, Radix Glycyrrhizae 12g, Radix Ginseng 6g, Rhizoma Zingiberis Recenss 18g, the Fructus Jujubae of 2 recipe quantities
25g), plus enough water loggings bubble, mood condition is once impregnated with interval of a period of time observation, until decoction pieces are all impregnated with, leaches whole
Unabsorbed aqueous, medicinal residues are weighed, and calculate decoction pieces water absorption rate.Water absorption rate computing formula：
Water absorption rate (%)=(decoction pieces weight in wet base-decoction pieces dry weight)/decoction pieces dry weight × 100%, is as a result shown in 1.
1 decoction pieces water absorption rate measurement result of table
From above result of the test, decoction pieces water absorption rate is about 200.7%, therefore adds 2 times of amount water when decocting first time.
(2) orthogonal test
Learnt with trial test by consulting literatures, the principal element for affecting extraction process is：Amount of water, soak time, carry
Take number of times, decocting time.Contained with ginsenoside Rb1 in the content of Hesperidin in Pericarpium Citri Reticulatae, the content of Radix Glycyrrhizae acid, Radix Ginseng
In amount, Rhizoma Zingiberis Recenss, the content and dry cream rate of 6-gingerol is index, chooses orthogonal test level, carries out orthogonal test.
With reference to trial test result, the level of each factor is determined.By four factors, per three level of factor, L is used9(34) orthogonal
Table carries out orthogonal test, and factor level table design is shown in Table 2.
2 extraction process factor level table of table
Test method：Weigh 1 recipe quantity decoction pieces (Pericarpium Citri Reticulatae 15g, Caulis Bambusae In Taenia 15g, Radix Glycyrrhizae 612g, Radix Ginseng 3g, Rhizoma Zingiberis Recenss 9g,
Fructus Jujubae 12.5g), it is heated to reflux by orthogonal test condition, medicinal liquid is filtered with 100 mesh filter clothes, and merging filtrate, filtrate decompression are dense
It is reduced to certain volume.
Evaluation index：With ginsenoside Rb1 in the content of Hesperidin, the content of Radix Glycyrrhizae acid, Radix Ginseng in Pericarpium Citri Reticulatae
In content, Rhizoma Zingiberis Recenss, the content of 6-gingerol and dry cream rate are index, carry out overall merit.
Dry cream rate assay method：Orthogonal test sample 25ml is drawn respectively, is put, water-bath
It is evaporated, in 105 DEG C of dryings 3 hours, moves in exsiccator, cool down 30 minutes, rapid precise weighing, calculates, obtain final product.
The assay of Hesperidin：According to high performance liquid chromatography (《Chinese Pharmacopoeia》0512) four general rules of version in 2015 are surveyed
It is fixed.
Chromatographic condition and system suitability：With octadecyl silane as filler；With acetonitrile as mobile phase A,
0.01% phosphate aqueous solution is Mobile phase B；Flow velocity is 1.0mL/min；Detection wavelength is 280nm；Column temperature is 27 DEG C.Theoretical tray
Number presses the calculating of Hesperidin peak should be less than 2000.Eluent gradient elution program is as shown in table 3.
3 eluent gradient elution program of table
The preparation of reference substance solution：Take Hesperidin reference substance appropriate, accurately weighed 5.31mg is settled to 50ml volumetric flasks
In, solution of every 1ml containing 0.1012mg is made, is obtained final product.
The preparation of need testing solution：It is accurate to draw 5ml medicinal liquids, it is placed in conical flask with cover, reduces pressure dense with Rotary Evaporators
Be reduced to it is dry, it is accurate to add methanol 25ml, weighed weight, supersound extraction (power 300W, frequency 45KHz) 30min to take out, put to
Room temperature, weighed weight, supplies the weight of less loss with methanol, shakes up again, filtration, takes subsequent filtrate, obtains final product.
Sample size is determined：It is accurate to draw above-mentioned 5 μ l of reference substance solution and 10 μ l of need testing solution, inject high-efficient liquid phase color
Spectrometer, determines, and calculates the content of Hesperidin.
The assay of glycyrrhizic acid：According to high performance liquid chromatography (《Chinese Pharmacopoeia》0512) four general rules of version in 2015 are surveyed
It is fixed.
Chromatographic condition and system suitability：With octadecyl silane as filler；With methanol as mobile phase A, with
0.2mol/L ammonium acetates-glacial acetic acid (33:1) be Mobile phase B, eluting is carried out by table 12-36 gradients；Detection wavelength is 250nm；Post
Temperature is 30 DEG C.
4 eluent gradient elution program of table
The preparation of reference substance solution：Extracting liquorice acid ammonium reference substance, accurately weighed 8.50mg, additive color spectrum methanol are made
The solution of 0.1583mg/mL, as reference substance solution.
The preparation of need testing solution：It is accurate to draw the corresponding medicinal liquid of each sample, it is placed in conical flask with cover, is steamed with rotation
Send out instrument and be evaporated to dry, accurate addition methanol 25mL, weighed weight, supersound extraction 30 minutes (power 300W, frequencies
45KHz), let cool, again weighed weight, the weight of less loss is supplied with methanol, shaken up, filter.Take subsequent filtrate and cross 0.45 μm of filter membrane
Sample introduction.
Sample size is determined：It is accurate to draw above-mentioned reference substance solution and each 10 μ l of need testing solution, inject high-efficient liquid phase color
Spectrometer, determines, and calculates the content of glycyrrhizic acid.
The assay of ginsenoside Rb1：According to high performance liquid chromatography (《Chinese Pharmacopoeia》Four general rules of version in 2015
0512) determine.
Chromatographic condition and system suitability：With octadecyl silane as filler；With acetonitrile as mobile phase A, with
0.1% phosphoric acid water is Mobile phase B, carries out eluting by table 12-37 gradients；Detection wavelength is 203nm；Column temperature is 30 DEG C.Sample size
For 10 μ L.
5 eluent gradient elution program of table
The preparation of reference substance solution：Take ginsenoside Rb1Reference substance, accurately weighed 6.55mg, plus methanol are made
The solution of 0.1256mg/mL, as reference substance solution.
The preparation of need testing solution：It is accurate to draw the corresponding medicinal liquid of each sample, it is placed in conical flask with cover, dilute with water
To 20ml, with chloroform extraction 3 times, each 20mL discards chloroform liquid, by aqueous water saturated n-butanol extraction 4
Secondary, each 20mL merges n-butyl alcohol liquid, is washed with ammonia solution 3 times, each 20mL, discard ammonia solution, and n-butyl alcohol liquid is evaporated, residual
Slag dissolves and is settled to 2mL volumetric flasks with methanol, obtains final product.
Sample size is determined：It is accurate to draw above-mentioned reference substance solution and 10 μ l of need testing solution, inject high performance liquid chromatography
Instrument, determines, and calculates the content of ginsenoside Rb1.
The assay of 6-gingerol：According to high performance liquid chromatography (《Chinese Pharmacopoeia》0512) four general rules of version in 2015 are surveyed
It is fixed.
Chromatographic condition and system suitability：With octadecyl silane as filler；With -0.1% phosphoric acid water of acetonitrile
(41：59) it is mobile phase；Detection wavelength is 280nm；Column temperature is 30 DEG C.
The preparation of reference substance solution：It is accurate to draw the 0.082185mg/ml 6-gingerol reference substance solution prepared
10ml, puts in 100ml volumetric flasks, and additive color spectrum methanol makes the solution of 8.12185 μ g/mL, as reference substance solution.
The preparation of need testing solution：It is accurate to draw the corresponding medicinal liquid of each sample, it is placed in conical flask with cover, is steamed with rotation
Send out instrument and be evaporated to dry, accurate addition 25mL methanol, weighed weight, supersound extraction 30 minutes (power 300W, frequencies
45KHz), let cool, again weighed weight, the weight of less loss is supplied with methanol, shaken up, filter.Precision measures subsequent filtrate 10mL, dense
It is reduced to dry, adding water makes dissolving, with chloroform extraction 4 times, each 20mL is concentrated to dryness, and residue is dissolved with methanol and is settled to
5mL volumetric flasks.
Sample size is determined：It is accurate to draw above-mentioned reference substance solution and 10 μ l of need testing solution, inject high performance liquid chromatography
Instrument, determines, and calculates the content of 6-gingerol.
(3) orthogonal experiment assay result and dry cream rate：
The each component content measurement result of 6 orthogonal experiment of table and dry cream rate
(4) each composition rate of transform result of orthogonal experiment：
The each composition rate of transform result of 7 orthogonal experiment of table
(5) quadrature analysis
The analytical table directly perceived that 8 content of hesperidin of table is determined
The analysis of variance table that table 12-41 content of hesperidin is determined
According to analysis directly perceived, optimal level is A3B2C3D3.Variance analyses show that extraction time is to Pericarpium Citri junoriss in four factors
Glycosides content has a significant impact, and not significantly, with reference to analysis directly perceived, its preferred processing condition is A to other influences factor0B0C3D3.
The analytical table directly perceived that 9 glycyrrhizic acid content of table is determined
The analysis of variance table that 10 glycyrrhizic acid content of table is determined
According to analysis directly perceived, optimal level is A2B2C2D3.Variance analyses show that extraction time is to Radix Glycyrrhizae in four factors
Acid content has a significant impact, and not significantly, with reference to analysis directly perceived, its preferred processing condition is A to other influences factor2B0C2D0。
The analytical table directly perceived of 11 ginsenoside Rb1's assay of table
The analysis of variance table of 12 ginsenoside Rb1's assay of table
According to analysis directly perceived, optimal level is A1B2C3D3.Variance analyses show, ginsenoside Rb1 are contained in four factors
There are no significant affects for amount, combines analysis directly perceived, and its preferred processing condition is A1B0C3D0。
The analytical table directly perceived of 13 6-gingerol assay of table
The analysis of variance table of 14 6-gingerol assay of table
According to analysis directly perceived, optimal level is A3B1C3D2.Variance analyses show that four factors are equal to 6-gingerol content
Affect without significance, with reference to analysis directly perceived, its preferred processing condition is A3B0C3D0。
The analytical table directly perceived of 15 dry cream rate of table
The analysis of variance table of 16 dry cream rate of table
According to analysis directly perceived, optimal level is A3B3C3D3.Variance analyses show that extraction time is to dry cream in four factors
Rate has a significant impact, and not significantly, with reference to analysis directly perceived, its preferred processing condition is A to other influences factor0B0C3D3。
(6) single interpretation
17 each composition summary sheet of table
(7) analyzed with comprehensive scoring method
18 content of table and weight coefficient distribution
The analytical table directly perceived of 19 comprehensive scoring method of table
The analysis of variance table of 20 comprehensive scoring method of table
According to analysis directly perceived, optimal level is A3B2C3D3.Variance analyses show that extraction time is to synthesis in four factors
Scoring has a significant impact, and with reference to analysis directly perceived, its preferred processing condition is A0B0C3D3。
Considered by single test analysis result, comprehensive scoring method result, extraction time is the master for affecting quality index
Factor is wanted, when optimal extraction technology is carried out, high spot reviews extraction time, extraction time are set to first time 1.5h, second 1h,
Third time 1h, amount of water is by 10 times, 8 times, 8 times of settings, it is contemplated that the difference between industrialization and laboratory, laboratory test
Scale is amplified to pilot plant and carries out pre- pilot scale, determines optimum extraction process with dry cream rate, the index components rate of transform.
3rd, concentrate condition test
Chinese medicinal granule is breakthrough and reform to Chinese medicine decoction.The concentration of extracting solution is the key of modern Chinese medicine preparation
One of operation, conventional method for concentration have normal pressure concentration and concentrating under reduced pressure etc..In addition, extracting solution novel concentrating process and new skill
Art also includes：Freeze concentration, reverse osmosis concentration, macroporous adsorbent resin separate concentration etc..With reference to big working condition and actual production
The feasibility of middle operation, intends adopting concentrating under reduced pressure in technical process, and this method operation is simple, continuously can produce, and have effectively into
Divide the advantages of heating temperature is low, the time is short.
It is according to the property of medicine, equipment performance and operating condition, and with reference to the needs of the big production in workshop, dense from reducing pressure
Contracting, is condensed into clear paste of the relative density in 1.06～1.12 (80 DEG C of surveys) under the conditions of 0.06～0.08MPa, 80 DEG C, filters
(100 mesh sieve).
Investigated with content of hesperidin, glycyrrhizic acid content, 6-gingerol content, ginsenoside Rb1's content as index.Press
Each index determining method is measured.The results are shown in Table 21.As a result show, before and after concentration, each index components content change is little, says
Bright concentration technology affects little to each index components.
The concentration of table 21 is investigated
4th, drying process research
Spray drying method has rate of drying fast, and production process is simple, and material heated time is short, and drying efficiency is high, product
Uniform color, the destruction of soluble, effective ingredient are few, and supplementary product consumption is few, and production process is simple, easy to operate, and controllability waits well special
Point, it is adaptable to which industry is big to be produced, and is a kind of better method for being applied to drying process in prepared by compound granular, in the Chinese prescription of Japan
In prepared by preparation, the method application is very extensive.
The factor being spray-dried is affected there are the several factors of extractum relative density, inlet temperature, supplementary product consumption, in pre- pilot scale
These three factors are investigated in journey, optimum process is chosen as working condition.Spray-drying process parameter such as following table：
Relative density is screened
Take Tangerine Peel and Bamboo Shavings Decoction difference relative density extractum, respectively according to relative density be 1.06,1.08,1.10,1.12
Condition carries out spray drying experiment, and its spray drying situation the results are shown in Table 22.
22 relative density of table is screened
As a result show：In the case of relative density is 1.06～1.08, slightly viscous wall is spray-dried, process is smooth, situation
Well, gained dry extract does not lump.
Inlet temperature is screened
Take Tangerine Peel and Bamboo Shavings Decoction extractum to be sprayed for 150 DEG C, 140 DEG C, 130 DEG C, 125 DEG C, 120 DEG C according to inlet temperature respectively
Mist drying test, its spray drying situation the results are shown in Table 23.
23 inlet temperature of table is screened
As a result show：In the case where inlet temperature is 125 DEG C, it is spray-dried, process is smoothly, all right,
Gained dry extract does not lump, does not glue wall.
Beta-schardinger dextrin-consumption is screened
Tangerine Peel and Bamboo Shavings Decoction extractum is taken respectively according to dry cream：Beta-schardinger dextrin-is 5:1、4:1、3:1 condition carries out spray drying examination
Test, its spray drying situation the results are shown in Table 24.
24 beta-schardinger dextrin-consumption of table is screened
As a result show：Adding adjuvant dry cream：Beta-schardinger dextrin-is 3:In the case of 1, it is spray-dried, process is smooth, feelings
Condition is good, and gained dry extract does not lump, do not glue wall.
Can be obtained by above result of the test, the spray drying condition of Tangerine Peel and Bamboo Shavings Decoction extractum is extractum relative density 1.06, is entered
The ratio of 125 DEG C of air temperature, dry cream and beta-schardinger dextrin-is 3:1.
Investigated with content of hesperidin, glycyrrhizic acid content, 6-gingerol content, ginsenoside Rb1's content as index.Press
Each index determining method is measured.The results are shown in Table 25.As a result show, before and after spray drying, each index components content changes not
Greatly, illustrate that drying process affects little to each index components.
Table 25 is spray-dried to be investigated
5th, granulation conditions test
The selection of method of granulating
Granulation is referred to toward the spice of powder and adds suitable wetting agent and adhesive, processed to make with a setting
The operation of the granular substance of shape and size.Chinese medicine granules granulation now has wet granulation, boiling using most method of granulating
Rise granulation and dry-pressing is pelletized.
Dry granulation technology be pharmaceuticals industry it is known after traditional wet-mixed granulation grow up it is a kind of new
Granulating process, it is the water of crystallization using material itself, directly material powder is compressed by mechanical presses → molding →
A kind of granulating process of broken → pelletize, its pelletization are the Chinese medicine extraction liquid that will have certain relative density, spray-dried
Obtain dry extract, after adding certain adjuvant, flakiness is extruded by rolling wheel set, subsequently by crushing mechanism is broken, granulate, mistake
Sieve, makes prescribed level, uniform product particle.
There are many advantages in dry granulation production process, no matter from yield, product quality, economic benefit, equipment investment etc.
Aspect obtains significant effect.After dry granulation improves the quality of product, original wet granulation technology needs addition
Solvent (such as ethanol), is then pelletized, is then dried, then tabletting.Solvent for adding in the middle of this and dry right for a long time
The impact of product quality is bigger.Some pharmaceutical raw materials do not allow oven drying yet.Dry granulation technology can utilize raw material itself
Viscosity and water of crystallization convection drying be extruded into pellet.Production process is simplified, the quality of product is improve.Once dry-pressing is pelletized
Engineer testing success, can change the granulating process method of existing solid preparation, reduce processing step, improve the efficiency of granulation, drop
Low energy consumption and carbon emission, to promoting pharmaceutical technology development, energy-conserving and environment-protective, have energetically meaning.
With many advantages compared with wet granulation technology, such as dry granulation needs the adjuvant of addition few to dry granulation,
Typically humidification and re-dry operation can be eliminated, the production cycle of product substantially reduced, simplified production work with straight forming
Sequence, reduce work personnel, saved labor cost, having saved supplementary material loss and wasted, reduced process losses, in addition
Dry granulation only needs to a dry granulating machine, therefore, plant area is saved, equipment investment is reduced, air-conditioning is saved, is cleaned into
This.Non-slurry pelletizing steam saving not airpillow-dry, without oscillating granulator consumption and maintenance service expense.Non-slurry pelletizing is auxiliary to original
Material composition influence is little, is conducive to the stability of raising system, and the disintegrate of granule and thawing dispersion.Non-slurry pelletizing has one to environment
Fixed protection, can avoid the use of bonding agent in wet-granulation process from solving dry gas and dust emissions, reduce each
Plant cleaning equipment and wastewater discharge.But while noise is larger in the drawbacks of dry granulation there is also certain, such as pelletization,
High cost shortcoming.
Investigated with content of hesperidin, glycyrrhizic acid content, 6-gingerol content, ginsenoside Rb1's content as index.Press
Each index determining method is measured.The results are shown in Table 26.As a result show, before and after granulation, each index components content change is little, says
Bright granulating process affects little to each index components.
26 granulating process of table is investigated
The selection of adjuvant and its consumption
The conventional adjuvant of granule mainly has：Starch, dextrin and its derivant, beta-schardinger dextrin-, Icing Sugar, Lactose etc..Due to
In this preparation prescription, Rhizoma Zingiberis Recenss, Fructus Jujubae proportion are larger, and viscosity is big, the easy moisture absorption, preferably select the adjuvant with humidity resistance.β-ring
Dextrin can be moistureproof, can make made by granule be difficult to absorb deliquescence.Therefore, from beta-schardinger dextrin-as using in drying process with atomizing
Adjuvant.Use ratio is had determined in drying process.
The characteristics of Lactose has compressible shaping and low water absorption, carries out dry-pressing granulation as filler, plays at regulation
The effect of side's amount of making.Prescription ratio see the table below, table 27.
27 prescription consumption of table
Daily dose, loading amount, the determination of specification
(1) take dosage day and loading amount specification determines
Daily crude drug amount is 60.5g to Tangerine Peel and Bamboo Shavings Decoction, and total extraction ratio is about 22.5%, adds beta-schardinger dextrin-and breast
After sugar granulation, total amount daily is 21g, per diem takes three calculating, and each dose is 7g；For convenience of clinical use
Medicine, therefore determine per packed 3.5g granules.
(2) preparation prescription
By the got dry extract rate of preparation technology, with reference to prescription consumption, determine that tangerine peel bamboo shavings granule prescription is：Pericarpium Citri Reticulatae 700-
730g, Caulis Bambusae In Taenia 700-730g, Radix Glycyrrhizae 270-300g, Radix Ginseng 135-155g, Rhizoma Zingiberis Recenss 410-450g, Fructus Jujubae 560-640g, β-ring paste
Smart appropriate Lactose is appropriate.
1000g processed altogether, per packed 3.5g, one time 2 bags, 3 times a day.
6th, clinical trial
Jing is more than to the vomiting during pregnancy made a definite diagnosis, the obstruction of pylorus imperfection, diaphragm spasm and postoperative singultuss etc., and category insufficiency of stomach has
80 people of hot person, per disease 20 people, 3 times for each person every day, per packed 3.5g, one time 2 bags, according to different syndromes, Time of Administration length is not
One, by decoction Time of Administration counting statistics curative effect, as a result average curative effect raising more than 10%, getting well for effect was not expected.
In a word, the present invention had both maintained decoction effect rapidly, the advantage of markedly fast, while and overcoming pan-fried when decoction is taken
The shortcoming of inconvenience is boiled, gained better stability of preparation takes, carries, preserving and convenient transportation, be the innovation in Chinese medicine preparation, Jing
Ji and social benefit are notable.
Claims (4)
1. a kind of preparation method of tangerine peel bamboo shavings granule, it is characterised in that by the material medicine Pericarpium Citri Reticulatae 700-730g of weight meter, bamboo
Eat 700-730g, Radix Glycyrrhizae 270-300g, Radix Ginseng 135-155g, Rhizoma Zingiberis Recenss 410-450g, Fructus Jujubae 560-640g and adjuvant Lactose, β-ring
Dextrin is made, and Pericarpium Citri Reticulatae, Caulis Bambusae In Taenia, Radix Glycyrrhizae, Radix Ginseng, Rhizoma Zingiberis Recenss and Fructus Jujubae are mixed, and adds water to cook twice, adds raw material for the first time
The water that 8 times of drug weight, decocts 1.5h, adds the water of 6 times of material medicine weight for the second time, decoct 1h, merge decocting liquid twice, mistake
Filter, filtrate are concentrated into the clear paste that 80 DEG C of relative densities are 1.10～1.15, are spray dried to fine powder, add in fine powder Lactose, β-
Cyclodextrin suppresses granulating to 1000g, Lactose, the weight ratio of beta-schardinger dextrin-are 22-44 ︰ 45-47.
2. the preparation method of tangerine peel bamboo shavings granule according to claim 1, it is characterised in that by the material medicine of weight meter
Pericarpium Citri Reticulatae 715g, Caulis Bambusae In Taenia 715g, Radix Glycyrrhizae 285g, Radix Ginseng 145g, Rhizoma Zingiberis Recenss 430g, Fructus Jujubae 595g and adjuvant Lactose, beta-schardinger dextrin-are made,
Pericarpium Citri Reticulatae, Caulis Bambusae In Taenia, Radix Glycyrrhizae, Radix Ginseng, Rhizoma Zingiberis Recenss and Fructus Jujubae are mixed, is added water to cook twice, add material medicine weight 8 for the first time
Times water, decoct 1.5h, second adds the water of 6 times of material medicine weight, decocts 1h, merges decocting liquid twice, filters, and filtrate is dense
The clear paste that 80 DEG C of relative densities are 1.10～1.15 is reduced to, fine powder is spray dried to, in fine powder, Lactose, beta-schardinger dextrin-is added extremely
1000g, suppresses granulating, Lactose, the weight ratio of beta-schardinger dextrin-are 22-44 ︰ 45-47.
3. the preparation method of tangerine peel bamboo shavings granule according to claim 1, it is characterised in that by the material medicine of weight meter
Pericarpium Citri Reticulatae 710g, Caulis Bambusae In Taenia 720g, Radix Glycyrrhizae 275g, Radix Ginseng 150g, Rhizoma Zingiberis Recenss 415g, Fructus Jujubae 635g and adjuvant Lactose, beta-schardinger dextrin-are made,
Pericarpium Citri Reticulatae, Caulis Bambusae In Taenia, Radix Glycyrrhizae, Radix Ginseng, Rhizoma Zingiberis Recenss and Fructus Jujubae are mixed, is added water to cook twice, add material medicine weight 8 for the first time
Times water, decoct 1.5h, second adds the water of 6 times of material medicine weight, decocts 1h, merges decocting liquid twice, filters, and filtrate is dense
The clear paste that 80 DEG C of relative densities are 1.10～1.15 is reduced to, fine powder is spray dried to, in fine powder, Lactose, beta-schardinger dextrin-is added extremely
1000g, suppresses granulating, Lactose, the weight ratio of beta-schardinger dextrin-are 22-44 ︰ 45-47.
4. the preparation method of tangerine peel bamboo shavings granule according to claim 1, it is characterised in that by the material medicine of weight meter
Pericarpium Citri Reticulatae 720g, Caulis Bambusae In Taenia 710g, Radix Glycyrrhizae 295g, Radix Ginseng 140g, Rhizoma Zingiberis Recenss 445g, Fructus Jujubae 565g and adjuvant Lactose, beta-schardinger dextrin-are made,
Pericarpium Citri Reticulatae, Caulis Bambusae In Taenia, Radix Glycyrrhizae, Radix Ginseng, Rhizoma Zingiberis Recenss and Fructus Jujubae are mixed, is added water to cook twice, add material medicine weight 8 for the first time
Times water, decoct 1.5h, second adds the water of 6 times of material medicine weight, decocts 1h, merges decocting liquid twice, filters, and filtrate is dense
The clear paste that 80 DEG C of relative densities are 1.10～1.15 is reduced to, fine powder is spray dried to, in fine powder, Lactose, beta-schardinger dextrin-is added extremely
1000g, suppresses granulating, Lactose, the weight ratio of beta-schardinger dextrin-are 22-44 ︰ 45-47.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108524885A (en) * | 2018-05-25 | 2018-09-14 | 王捍东 | A kind of preparation method for treating the Chinese medicinal granule of brain tumor |
| CN113041335A (en) * | 2021-03-17 | 2021-06-29 | 四川大学青岛研究院 | A composition containing pericarpium Citri Tangerinae and caulis Bambusae in Taenia |
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2016
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108524885A (en) * | 2018-05-25 | 2018-09-14 | 王捍东 | A kind of preparation method for treating the Chinese medicinal granule of brain tumor |
| CN113041335A (en) * | 2021-03-17 | 2021-06-29 | 四川大学青岛研究院 | A composition containing pericarpium Citri Tangerinae and caulis Bambusae in Taenia |
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