CN108524885A - A kind of preparation method for treating the Chinese medicinal granule of brain tumor - Google Patents

A kind of preparation method for treating the Chinese medicinal granule of brain tumor Download PDF

Info

Publication number
CN108524885A
CN108524885A CN201810513282.3A CN201810513282A CN108524885A CN 108524885 A CN108524885 A CN 108524885A CN 201810513282 A CN201810513282 A CN 201810513282A CN 108524885 A CN108524885 A CN 108524885A
Authority
CN
China
Prior art keywords
parts
radix
chinese medicinal
medicinal granule
root
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810513282.3A
Other languages
Chinese (zh)
Inventor
王捍东
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201810513282.3A priority Critical patent/CN108524885A/en
Publication of CN108524885A publication Critical patent/CN108524885A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714—Aconitum (monkshood)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/43—Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/487—Psoralea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/51—Gentianaceae (Gentian family)
    • A61K36/515—Gentiana
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888—Pinellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of preparation methods for treating the Chinese medicinal granule of brain tumor, using two Ten Herbs such as unprocessed Radix Aconiti Lateralis, sealwort, actinolite, radix bupleuri, raw sulphur, Radix Curcumae, dried pinellia, radix rehmanniae preparata, psoralea corylifolia, the root of fangji, cassia twig, honey-fried licorice root, Radix Paeoniae Alba, the root of three-nerved spicebush, Semen Cuscutae, oriental wormwood, felwort, Rhizoma Chuanxiong, ginger, jujubes as raw material, using formula, extraction, homogeneous, concentration, drying, compacting granulating and etc. be prepared into particle, it overcomes decoction decocting, carrying, store inconvenient disadvantage, there is significant market popularization value.The Chinese medicinal granule stability being prepared using the present invention is high, maintains the original active ingredient of decoction, have the advantages that effect rapidly, markedly fast, take that mode is simple, with considerable medicine promotion prospect；Simultaneously the present invention creatively realize traditional Chinese herbal decoction to the propulsion of Chinese medicinal granule change, preparation method is simple, device requirement amount it is small and operation require it is low, it is easy to accomplish volume production, have significant economical, societal benefits.

Description

A kind of preparation method for treating the Chinese medicinal granule of brain tumor
Technical field
The present invention relates to the preparing technical fields of Chinese medicinal granule, and in particular to a kind of for treating the Chinese medicinal granule of brain tumor Preparation method.
Background technology
Chinese medicine thinks that brain tumor is the disease of cloudy reality caused by interior cold severe, kidney yang insufficiency of essence, hepar damnification.According to six city of China It is investigated in city resident, intracranial tumors illness rate is 32/,100,000, and a global statistics is 40/,100,000, and incidence is higher, value It must pay attention to.
Currently, most basic, the maximally efficient therapy for the treatment of brain tumor is to use surgical therapy, however, this method The postoperative complications such as infection, fever, pain are likely to cause, the burden of making patients also brings the risk of bigger to patient.And Compared with surgical therapy, traditional Chinese medical herbal treatment method can not only inhibit and kill tumour cell, and can effectively adjust and Improve the immune function of human body.Meanwhile the side effect for caused by inhibiting brain tumor chemicotherapy of traditional Chinese medical herbal treatment method also have it is aobvious Write effect.And existing traditional Chinese medical herbal treatment method is generally by the way of taking decoction, each taking when must decoct, decoct it is good it After carry, store and transport extremely inconvenient, and decoction bitter amount is big, and popularization is restricted.
Invention content
The present invention is intended to provide one kind can effectively overcome traditional Chinese herbal decoction is existing decoct, carry, transporting inconvenient, bitter Measure the preparation method of the Chinese medicinal granule for treating brain tumor of the shortcomings of big.
To solve the above-mentioned problems, the present invention uses following technical scheme：A kind of Chinese medicinal granule for treating brain tumor Preparation method includes the following steps：
（1）Formula：It is sweet with unprocessed Radix Aconiti Lateralis, sealwort, actinolite, radix bupleuri, Radix Curcumae, dried pinellia, radix rehmanniae preparata, psoralea corylifolia, the root of fangji, cassia twig, toast Grass, Radix Paeoniae Alba, the root of three-nerved spicebush, Semen Cuscutae, oriental wormwood, felwort, Rhizoma Chuanxiong, ginger, blood clam, jujube are raw material, according to recipe ratio after impurity elimination It is spare after example precise；
（2）Extraction：The load weighted feed components are placed in extractor, and water is added in the extractor and carries out just Secondary decoction extraction, continuous heating and after keeping boiling 1.5-2.0 hours carry out separating liquid medicine, and will be after separation using strainer Drug is placed in the extractor, water is added carries out secondary decoctions and extract, continuous heating and after keeping boiling 1.0-1.5 hours, Carry out slag-liquid separation；
（3）Homogeneous：In lasting whipping process, liquid isolated twice and the life sulphur for being crushed to 80-100 mesh are added Enter in agitator tank and is uniformly mixed；
（4）Concentration：Uniformly mixed liquid is placed in dual-effect concentrator, it is opposite to concentrate the liquid at 75-85 DEG C The clear cream that density is 1.10-1.15；
（5）It is dry：The clear cream is placed in spray drying tower, it is naturally cold after 30 minutes are continued drying out at 300-350 DEG C But 8-10 hours, the clear cream powder of 80-100 mesh is ground into after the completion of cooling using pulverizer；
（6）Suppress granulating：According to lactose：The weight ratio of beta-cyclodextrin is 1-2：2.25-2.35 ratio prepares auxiliary material, and presses According to auxiliary material：Clear cream powder：The weight ratio of ethyl alcohol is 2-5：1.0：3-7 ratio after mixing, is placed in facility for granulating and suppresses At the spherical of 0.5-0.8 cm of diameter, using after box drier or fluidized bed drying up to product.
Further, the weight fraction of each raw material component is respectively：340-380 parts of unprocessed Radix Aconiti Lateralis, sealwort 160-200 Part, 280-320 parts of actinolite, 160-200 parts of radix bupleuri, 280-320 parts of Radix Curcumae, 160-200 parts of dried pinellia, radix rehmanniae preparata 160- 200 parts, 160-200 parts of psoralea corylifolia, 160-200 parts of the root of fangji, 280-320 parts of cassia twig, 280-320 parts of honey-fried licorice root, Radix Paeoniae Alba 280-320 parts, 160-200 parts of the root of three-nerved spicebush, 160-200 parts of Semen Cuscutae, 160-200 parts of oriental wormwood, 160-200 parts of felwort, river 160-200 parts of rhizome of chuanxiong, 100-140 parts of ginger, 280-320 parts of blood clam, 1900-2100 parts of jujube, raw sulphur 280-320 Part.
Further, the dried pinellia is the non-irrigated tuber of pinellia.
Further, the addition of first water when decocting extraction is 7-9 times of the drug total amount, described secondary to decoct The addition of water is 5-7 times of the drug total amount when boiling extraction.
Further, temperature condition is when the decoction：150-180 DEG C are used before boiling, Wen Tenghou uses 80-120 DEG C.
Further, the volume fraction of the ethyl alcohol is 75-95%.
Compared with the prior art, the present invention has the following advantages：
（1）The present invention is with unprocessed Radix Aconiti Lateralis, sealwort, actinolite, radix bupleuri, raw sulphur, Radix Curcumae, dried pinellia, radix rehmanniae preparata, psoralea corylifolia, the root of fangji, osmanthus 20 a herb such as branch, honey-fried licorice root, Radix Paeoniae Alba, the root of three-nerved spicebush, Semen Cuscutae, oriental wormwood, felwort, Rhizoma Chuanxiong, ginger, blood clam, jujube is made For raw material, using formula, extraction, homogeneous, concentration, drying, compacting granulating and etc. be prepared into particle, overcome decoction decocting, It carries, the disadvantage that storage is inconvenient, there is significant market popularization value.
（2）The present invention adds lactose as diluent in compacting granulation step, not only reduces granulation difficulty, Er Qieyou Effect improves medicament mouthfeel, takes more convenient.
（3）The Chinese medicinal granule stability being prepared using the present invention is high, maintains the original active ingredient of decoction, has The advantages of effect is rapid, markedly fast, takes that mode is simple, has considerable medicine promotion prospect.
（4）The present invention makes Chinese herbal medicine raise speed effect using modern science and technology, so that drug effect is gone directly rapidly lesion, solves Chinese medicine and control The slow problem of drug effect is treated, traditional Chinese herbal decoction is creatively realized and changes to the propulsion of Chinese medicinal granule, preparation method is simple, and equipment needs The amount of asking it is small and operation require it is low, it is easy to accomplish volume production, have significant economical, societal benefits.
Specific implementation mode
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention It is described further.
Embodiment 1：A kind of preparation for treating the Chinese medicinal granule of brain tumor
（1）Formula：34 g of unprocessed Radix Aconiti Lateralis, 16 g of sealwort, 28 g of actinolite, the bavin handled through impurity elimination according to formula rate precise Recklessly 16 g, 28 g of Radix Curcumae, 16 g of dried pinellia, 16 g of radix rehmanniae preparata, 16 g of psoralea corylifolia, 16 g of the root of fangji, 28 g of cassia twig, 28 g of honey-fried licorice root, 28 g of Radix Paeoniae Alba, 16 g of the root of three-nerved spicebush, 16 g of Semen Cuscutae, 16 g of oriental wormwood, 16 g of felwort, 16 g of Rhizoma Chuanxiong, 10 g of ginger, blood clam 28 G, 190 g of jujube is spare；Dried pinellia is the non-irrigated tuber of pinellia；
（2）Extraction：The load weighted feed components are placed in extractor, and it is that drug is total that weight, which is added, in extractor It measures 7 times of water and carries out first decoction extraction, continuous heating is simultaneously kept after boiling 1.5 hours, after carrying out separating liquid medicine using strainer, Drug after separation is placed in extractor, the water that weight is 5 times of drug total amount is added and carries out secondary decoction extraction, continuous heating And after keeping boiling 1.0 hours, slag-liquid separation is carried out；Temperature requirement is when decoction：150 DEG C are used before boiling, Wen Tenghou is used 80℃；
（3）Homogeneous：In lasting whipping process, the life sulphur that liquid isolated twice and 28 g are crushed to 80 mesh is added It is uniformly mixed in agitator tank；
（4）Concentration：Uniformly mixed liquid is placed in dual-effect concentrator, is for relative density by liquid concentration at 75 DEG C 1.10 clear cream；
（5）It is dry：Clear cream is placed in spray drying tower, after 30 minutes are continued drying out at 300 DEG C, natural cooling 8 hours is cold But the clear cream powder of 80 mesh is ground into after the completion of using pulverizer；
（6）Suppress granulating：According to lactose：The weight ratio of beta-cyclodextrin is 1：After 2.25 ratio prepares auxiliary material, and accurately weigh 1100 g of auxiliary material is added in clear cream powder, while the ethyl alcohol that 1650 g volume fractions are 95% is added after mixing, is placed in granulation and sets Be pressed into the spherical of 0.5-0.8 cm of diameter in standby, using after box drier or fluidized bed drying up to product.
Embodiment 2：A kind of preparation for treating the Chinese medicinal granule of brain tumor
（1）Formula：36 g of unprocessed Radix Aconiti Lateralis, 18 g of sealwort, 30 g of actinolite, the bavin handled through impurity elimination according to formula rate precise 18 g, 30 g of Radix Curcumae, 18 g of dried pinellia, 18 g of radix rehmanniae preparata, 18 g of psoralea corylifolia, 18 g cassia twig of the root of fangji, 30 g, 30 g of honey-fried licorice root, white recklessly 30 g of Chinese herbaceous peony, 18 g of the root of three-nerved spicebush, 18 g of Semen Cuscutae, 18 g of oriental wormwood, 18 g of felwort, 18 g of Rhizoma Chuanxiong, 12 g of ginger, 30 g of blood clam, 200 g of jujube is spare；Dried pinellia is the non-irrigated tuber of pinellia；
（2）Extraction：The load weighted feed components are placed in extractor, and it is that drug is total that weight, which is added, in extractor It measures 8 times of water and carries out first decoction extraction, continuous heating is simultaneously kept after boiling 1.75 hours, and separating liquid medicine is carried out using strainer Afterwards, the drug after separation is placed in extractor, the water that weight is 5 times of drug total amount is added and carries out secondary decoction extraction, continues After heating and keeping boiling 1.25 hours, slag-liquid separation is carried out；Temperature requirement is when decoction：165 DEG C are used before boiling, Wen Tenghou Using 100 DEG C；
（3）Homogeneous：In lasting whipping process, the life sulphur that liquid isolated twice and 30 g are crushed to 90 mesh is added It is uniformly mixed in agitator tank；
（4）Concentration：Uniformly mixed liquid is placed in dual-effect concentrator, is for relative density by liquid concentration at 80 DEG C 1.125 clear cream；
（5）It is dry：Clear cream is placed in spray drying tower, after 30 minutes are continued drying out at 325 DEG C, natural cooling 9 hours is cold But the clear cream powder of 90 mesh is ground into after the completion of using pulverizer；
（6）Suppress granulating：According to lactose：The weight ratio of beta-cyclodextrin is 1.5：After 2.30 ratio prepares auxiliary material, and accurately claim It takes 2191 g of auxiliary material to be added in clear cream powder, while the ethyl alcohol that 3130 g volume fractions are 85% is added after mixing, be placed in granulation The spherical of 0.5-0.8 cm of diameter is pressed into equipment, using after box drier or fluidized bed drying up to product.
Embodiment 3：A kind of preparation for treating the Chinese medicinal granule of brain tumor
（1）Formula：38 g of unprocessed Radix Aconiti Lateralis, 20 g of sealwort, 32 g of actinolite, the bavin handled through impurity elimination according to formula rate precise Recklessly 20 g, 32 g of Radix Curcumae, 20 g of dried pinellia, 20 g of radix rehmanniae preparata, 20 g of psoralea corylifolia, 20 g of the root of fangji, 32 g of cassia twig, 32 g of honey-fried licorice root, 32 g of Radix Paeoniae Alba, 20 g of the root of three-nerved spicebush, 20 g of Semen Cuscutae, 20 g of oriental wormwood, 20 g of felwort, 20 g of Rhizoma Chuanxiong, 14 g of ginger, blood clam 32 G, 210 g of jujube is spare；Dried pinellia is the non-irrigated tuber of pinellia；
（2）Extraction：The load weighted feed components are placed in extractor, and it is that drug is total that weight, which is added, in extractor It measures 8 times of water and carries out first decoction extraction, continuous heating is simultaneously kept after boiling 2.0 hours, will after carrying out separating liquid medicine using strainer Drug after separation is placed in extractor, and the water that weight is 5 times of drug total amount is added and carries out secondary decoction extraction, continuous heating is simultaneously After keeping boiling 1.5 hours, slag-liquid separation is carried out；Temperature requirement is when decoction：180 DEG C are used before boiling, Wen Tenghou uses 120 ℃；
（3）Homogeneous：In lasting whipping process, the life sulphur that liquid isolated twice and 32 g are crushed to 100 mesh adds Enter in agitator tank and is uniformly mixed；
（4）Concentration：Uniformly mixed liquid is placed in dual-effect concentrator, is for relative density by liquid concentration at 80 DEG C 1.125 clear cream；
（5）It is dry：Clear cream is placed in spray drying tower, after 30 minutes are continued drying out at 350 DEG C, natural cooling 10 hours, The clear cream powder of 90 mesh is ground into after the completion of cooling using pulverizer；
（6）Suppress granulating：According to lactose：The weight ratio of beta-cyclodextrin is 2.0：After 2.35 ratio prepares auxiliary material, and accurately claim It takes 3370 g of auxiliary material to be added in clear cream powder, while the ethyl alcohol that 4718 g volume fractions are 75% is added after mixing, be placed in granulation The spherical of 0.5-0.8 cm of diameter is pressed into equipment, using after box drier or fluidized bed drying up to product.
1-3 outturn sample of Example is respectively used to following Patients with Brain Tumors, and statistics therapeutic effect is as follows：
（1）Patient's first, man, 40 years old, symptom：Right eye ptosis, left limb limitation of activity, companion are 1 month clouded in mind, at certain Hospital checks that head B-sonography is diagnosed as hypothalamic glioma（3.1×4.3×3.5cm3）, start to take 1 drug sample of embodiment then, After continuously taking 90 days, shown in certain hospital check head B-sonography：Hypothalamic glioma, knurl are obviously reduced, and peripheral edema disappears；
（2）Patient's second, man, 52 years old, symptom：In October, 2016 is because headache, dizziness, visual impairment are in certain hospital's row third ventricular tumor Operation excision, postoperative pathological report II-III grade of astrocytoma, totally 3 treatments of postoperative progress X knives, Whole-brain radiotherapy and brave and fierce chemotherapy Journey, in November, 2017 headache, dizziness are sent out again；Head B-sonography shows：Diacele After gliomas operation recurs（Knurl 3 × 3.2 × 3.5cm3）The ventricles of the brain expand, and in December, 2017 after second of row tumour of certain hospital does nearly total resection, postoperative pathological shows star V grades of shape cytoma III-I started to take 2 drug sample of embodiment on January 10th, 2018, and on March 15th, 2018, MRI showed：Three Ventricles of the brain astrocyte knurl remains（1.0×1.2×0.9cm3）；
（3）Patient third, man, 47 years old, and in June, 2005 because headache binocular vision is 2 months fuzzy, is examined as hypophysoma, parallel operation Treatment, postsurgery symptoms are alleviated, in September, 2006 because of interruption headache, it is small without beard and development, without sexual drive, check head CT shows： Hypophysoma postoperative recurrence（2.6×3.0cm2）, the same year September starts to take 3 drug sample of embodiment, after 40 days headache obviously subtract Gently, after 7 months, headache disappears, and occasionally has sexual drive, checks head CT again and shows：Rarely seen ephippium expands, and has no the residual of tumour And recurrence sign.
The drug sample that can be seen that embodiment 1,2,3 from the above treatment case there is significant treatment to imitate brain tumor Fruit.Therefore, the present invention makes Chinese herbal medicine raise speed effect using modern science and technology, so that drug effect is gone directly rapidly lesion, solves Chinese medicine treatment The slow problem of drug effect, while overcoming decoction decocting, carrying, storing inconvenient disadvantage, the Chinese medicinal granule being prepared is stablized Property it is high, maintain the original active ingredient of decoction, have the advantages that effect rapidly, markedly fast, it is simple to take mode, creatively It realizes traditional Chinese herbal decoction to the propulsion of Chinese medicinal granule to change, there are significant economical, societal benefits.
It should be noted that the above examples are only used to illustrate the technical scheme of the present invention and are not limiting.Although with reference to reality Example is applied to describe the invention in detail, it will be apparent to an ordinarily skilled person in the art that technical scheme of the present invention into Row modification or equivalent replacement should all cover the power in the present invention without departure from the spirit and scope of technical solution of the present invention In sharp claimed range.

Claims (6)

1. a kind of preparation method for treating the Chinese medicinal granule of brain tumor, it is characterised in that：Include the following steps：
（1）Formula：It is sweet with unprocessed Radix Aconiti Lateralis, sealwort, actinolite, radix bupleuri, Radix Curcumae, dried pinellia, radix rehmanniae preparata, psoralea corylifolia, the root of fangji, cassia twig, toast Grass, Radix Paeoniae Alba, the root of three-nerved spicebush, Semen Cuscutae, oriental wormwood, felwort, Rhizoma Chuanxiong, ginger, blood clam, jujube are raw material, according to recipe ratio after impurity elimination It is spare after example precise；
（2）Extraction：The load weighted feed components are placed in extractor, and water is added in the extractor and carries out just Secondary decoction extraction, continuous heating and after keeping boiling 1.5-2.0 hours carry out separating liquid medicine, and will be after separation using strainer Drug is placed in the extractor, water is added carries out secondary decoctions and extract, continuous heating and after keeping boiling 1.0-1.5 hours, Carry out slag-liquid separation；
（3）Homogeneous：In lasting whipping process, liquid isolated twice and the life sulphur for being crushed to 80-100 mesh are added Enter in agitator tank and is uniformly mixed；
（4）Concentration：Uniformly mixed liquid is placed in dual-effect concentrator, it is opposite to concentrate the liquid at 75-85 DEG C The clear cream that density is 1.10-1.15；
（5）It is dry：The clear cream is placed in spray drying tower, it is naturally cold after 30 minutes are continued drying out at 300-350 DEG C But 8-10 hours, the clear cream powder of 80-100 mesh is ground into after the completion of cooling using pulverizer；
（6）Suppress granulating：According to lactose：The weight ratio of beta-cyclodextrin is 1-2：2.25-2.35 ratio prepares auxiliary material, and presses According to auxiliary material：Clear cream powder：The weight ratio of ethyl alcohol is 2-5：1.0：3-7 ratio after mixing, is placed in facility for granulating and suppresses At the spherical of 0.5-0.8 cm of diameter, using after box drier or fluidized bed drying up to product.
2. a kind of preparation method for treating the Chinese medicinal granule of brain tumor according to claim 1, it is characterised in that：It is described The weight fraction of feed components is respectively：340-380 parts of unprocessed Radix Aconiti Lateralis, 160-200 parts of sealwort, 280-320 parts of actinolite, 160-200 parts of radix bupleuri, 280-320 parts of Radix Curcumae, 160-200 parts of dried pinellia, 160-200 parts of radix rehmanniae preparata, psoralea corylifolia 160-200 Part, 160-200 parts of the root of fangji, 280-320 parts of cassia twig, 280-320 parts of honey-fried licorice root, 280-320 parts of Radix Paeoniae Alba, the root of three-nerved spicebush 160-200 Part, 160-200 parts of Semen Cuscutae, 160-200 parts of oriental wormwood, 160-200 parts of felwort, 160-200 parts of Rhizoma Chuanxiong, ginger 100- 140 parts, 280-320 parts of blood clam, 1900-2100 parts of jujube, raw 280-320 parts of sulphur.
3. a kind of preparation method for treating the Chinese medicinal granule of brain tumor according to claim 1, it is characterised in that：It is described Dried pinellia is the non-irrigated tuber of pinellia.
4. a kind of preparation method for treating the Chinese medicinal granule of brain tumor according to claim 1, it is characterised in that：It is described The addition of water is 7-9 times of the drug total amount when decocting extraction for the first time, and the addition of water is when the secondary decoction is extracted 5-7 times of the drug total amount.
5. a kind of preparation method for treating the Chinese medicinal granule of brain tumor according to claim 1, it is characterised in that：It is described Temperature condition is when decoction：150-180 DEG C are used before boiling, Wen Tenghou uses 80-120 DEG C.
6. a kind of preparation method for treating the Chinese medicinal granule of brain tumor according to claim 1, it is characterised in that：It is described The volume fraction of ethyl alcohol is 75-95%.
CN201810513282.3A 2018-05-25 2018-05-25 A kind of preparation method for treating the Chinese medicinal granule of brain tumor Pending CN108524885A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810513282.3A CN108524885A (en) 2018-05-25 2018-05-25 A kind of preparation method for treating the Chinese medicinal granule of brain tumor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810513282.3A CN108524885A (en) 2018-05-25 2018-05-25 A kind of preparation method for treating the Chinese medicinal granule of brain tumor

Publications (1)

Publication Number Publication Date
CN108524885A true CN108524885A (en) 2018-09-14

Family

ID=63471920

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810513282.3A Pending CN108524885A (en) 2018-05-25 2018-05-25 A kind of preparation method for treating the Chinese medicinal granule of brain tumor

Country Status (1)

Country Link
CN (1) CN108524885A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109200246A (en) * 2018-11-08 2019-01-15 邹怀亮 A kind of Chinese medicine for the treatment of cancer and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101879244A (en) * 2009-05-08 2010-11-10 北京绿源求证科技发展有限责任公司 Traditional Chinese medicine for treating cerebral tumors
CN105311578A (en) * 2015-11-30 2016-02-10 山东省立医院 Traditional Chinese medicine composition for treating intracranial tumors
CN106540233A (en) * 2016-12-23 2017-03-29 仲景宛西制药股份有限公司 A kind of preparation method of tangerine peel bamboo shavings granule

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101879244A (en) * 2009-05-08 2010-11-10 北京绿源求证科技发展有限责任公司 Traditional Chinese medicine for treating cerebral tumors
CN105311578A (en) * 2015-11-30 2016-02-10 山东省立医院 Traditional Chinese medicine composition for treating intracranial tumors
CN106540233A (en) * 2016-12-23 2017-03-29 仲景宛西制药股份有限公司 A kind of preparation method of tangerine peel bamboo shavings granule

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
李竹庭等: ""脑瘤散对脑胶质瘤细胞 GFAP及Bax/Bcl-2的影响"", 《天津中医药》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109200246A (en) * 2018-11-08 2019-01-15 邹怀亮 A kind of Chinese medicine for the treatment of cancer and preparation method thereof

Similar Documents

Publication Publication Date Title
CN102091203B (en) External traditional Chinese medicine preparation for treating chronic wounds and preparation method thereof
CN105920194A (en) Anti-tumor traditional Chinese medicinal agent
CN107929629A (en) One kind prolongs age and consolidates ball and preparation method thereof
CN105055849B (en) Enriching yin Chinese medical extract for nourishing kidney and its preparation method and application
CN105560748A (en) Toxin drawing-out cream and preparation method thereof
CN108524885A (en) A kind of preparation method for treating the Chinese medicinal granule of brain tumor
CN104161864A (en) External-use plaster for tonifying spleen and tonifying stomach and preparation method thereof
CN105999105A (en) Traditional Chinese medicine composition for treating bedsores and diabetic ulcers and preparation method thereof
CN102846739B (en) Navel-applied plaster for treating hepatitis and preparation method thereof
WO2022016827A1 (en) Compound preparation for neuranagenesis, and preparation method therefor and use thereof
CN103705760B (en) A kind of suppository preparation method for postpartum perineum pain
CN113244356A (en) Traditional Chinese medicine composition for treating psoriasis
CN108524576B (en) Pharmaceutical composition for treating impotence, medicine and preparation method of medicine
CN105853866A (en) Method for preparing Chinese herbal medicine composition for treating bedsore
CN104888121A (en) Traditional Chinese medicine extract for adjuvant therapy of pelvic inflammation, preparation method and application of traditional Chinese medicine extract, and body cream
CN107929492A (en) A kind of strong doctor's external preparation for treating abscess and preparation method thereof
CN103816307B (en) Nerve growth restorative bolus and preparation method thereof
CN108379515B (en) Medicine with angina pectoris treating effect and preparation method thereof
CN107875288A (en) Preparation method with promoting blood circulation, the Chinese medicine composition of beauty functions and its granule
CN107233406A (en) A kind of traditional Chinese medicine for outer use for treating hormone face
CN105596566A (en) Traditional Chinese medicine for treating fundus hemorrhage and preparation method thereof
CN105056160A (en) Medicine composition for treating agalactia of cows and preparation method thereof
CN105288086A (en) Traditional Chinese medicine composition for treating cerebral thrombosis and preparing method thereof
CN104491750B (en) Scope nipple portion is coordinated to cut the Chinese medicine of associating balloon expandable operative treatment calculus of bile duct
CN104547021A (en) Compound motherwort herb mixture as well as preparation method and application thereof in treatment of gynecological diseases

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20180914