CN109123672A - A kind of Moringa composition, granule, pressed candy and the preparation method and application thereof - Google Patents
A kind of Moringa composition, granule, pressed candy and the preparation method and application thereof Download PDFInfo
- Publication number
- CN109123672A CN109123672A CN201810991084.8A CN201810991084A CN109123672A CN 109123672 A CN109123672 A CN 109123672A CN 201810991084 A CN201810991084 A CN 201810991084A CN 109123672 A CN109123672 A CN 109123672A
- Authority
- CN
- China
- Prior art keywords
- moringa
- extract
- leaf
- roselle
- berries
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/48—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The present invention provides a kind of Moringa compositions, granule, pressed candy and the preparation method and application thereof.The Moringa composition includes in mass ratio (4~8): (1~2): the moringa oleifera leaf extractive of (1~4) calculating, roselle extract, acai berry extract, with norcholesterol and triglyceride, drop LDL and oxidation resistant effect, and the bitterness and pungent of leaf of Moringa can be covered well.The present invention also provides Moringa mixture pellets and pressed candies, are convenient for carrying transport, and storage tolerance is easy to use, and taste flavor is superior, sour-sweet middle band nature fragrance, and product colour is beautiful, granule brew after in rose-red, color is beautiful.The present invention also provides the preparation methods of the Moringa composition, granule, pressed candy, successfully solve granulation, in tabletting roselle, leaf of Moringa and the Brazilian certain kind of berries the apparent hygroscopicity problems of extract, simple process and stabilization, cost is relatively low, has good industry promotion prospect.
Description
Technical field
The invention belongs to food and technical field of functional food, in particular to a kind of Moringa composition, granule, pressed candy
Fruit and the preparation method and application thereof.
Background technique
Moringa (Moringa oleifera Lam.) is Moringa suborder Moringaceae (Moringaceae) Moringa
(Moringa) plant also known as drumstick tree, " horseradish wood ", " Ma Luobu ", " not setting extremely ", " Luo Bushu ".Moringa complete stool is edible, contains
There are protein, lipid, carbohydrate and vitamin abundant etc., in many developing countries as the dietary supplements generally used,
There are augment nutritional, the function of Dietotherapy health.It is recorded according to Ayurvedic medicine, root, bark, pod and leaf can be used for a variety of diseases
Prevention and treatment.Modern research shows that Moringa has anti-oxidant, liver protection, removing toxic substances, antitumor, reducing blood lipid, hypoglycemic, blood pressure lowering, anti-inflammatory town
Bitterly, it relievings asthma, is anti-radiation, antiulcer, antibacterial, wound healing promoting and other effects.In terms of reducing blood lipid and antiatherosclerosis,
Chumark P etc. (Chumark P, et al.2008) confirms that leaf of Moringa water extract is to High cholesterol diet by zoopery
The hyperlipidemia Rabbit Model of induction has effect for reducing fat, has prevention effect to the formation of atherosclerotic plaque.Mehta K etc.
(Mehta K, et al.2003) handles hypercholesterolemia Rabbits Models with Moringa and Lovastatin, continuous 120 days, as a result sends out
Serum cholesterol, phosphatide, triglycerides, VLDL, LDL of existing Rabbits Models are horizontal and atherogenic index reduces.Moreover, high gallbladder
After Lovastatin and Moringa processing, the lipidosis of liver, heart and aorta substantially reduces sterol blood stasis model rabbit.
Jain PG etc. (Jain P.G, et al.2010) uses Moringa methanolic extract and simvastatin continuous processing 30 days, observes
Influence to high blood lipid model experimental rat, as a result, it has been found that the serum cholesterol of high blood lipid model experimental rat, triglycerides,
VLDL, the ratio of LDL cholesterol and phosphatide and atherogenic index are substantially reduced, and HDL is horizontal significantly raised, and having reduces high blood
Rouge effect.
But leaf of Moringa has special bitterness and pungent, it is difficult to entrance, and moringa oleifera leaf extractive is in yellowish-brown, very greatly
Moringa is limited in degree in the exploitation and popularization of food or functional food.Meanwhile inventor has found under study for action, leaf of Moringa mentions
Taking object, there are apparent hygroscopicity problems, to the shaped preparation for developing using Moringa as effective component and meeting National Pharmacopeia requirement
Product (such as granule) proposes many technological challenges, needs to research and solve and overcome.
Summary of the invention
The first object of the present invention is the shortcomings that overcoming the prior art and deficiency, provides a kind of Moringa composition.
The second object of the present invention is to provide a kind of preparation method of Moringa mixture pellets.
The third object of the present invention is to provide the Moringa mixture pellets as made from the preparation method.
The fourth object of the present invention is to provide a kind of compound pressed candy of Moringa and preparation method thereof.
The fifth object of the present invention is to provide the application of the Moringa composition.
The purpose of the invention is achieved by the following technical solution:
A kind of Moringa composition includes moringa oleifera leaf extractive, roselle extract, acai berry extract, the Moringa
Leaf extract, roselle extract, acai berry extract (4~8) in mass ratio: (1~2): (1~4) proportion, the Moringa
Leaf extract, roselle extract, acai berry extract extract obtain by the following method: by dry leaf of Moringa, Roselle flower
Calyx or Brazilian certain kind of berries fruit powder press solid-liquid ratio 1kg ︰ (5~25) L extracting in water, 50 DEG C~100 DEG C heating extraction 1~3 time, mention every time
Take 0.3~2h (set temperature is raised to Extracting temperature and starts timing).The Moringa composition has norcholesterol and glycerol
Three rouge, drop LDL and oxidation resistant effect, and the bitterness and pungent of leaf of Moringa can be covered well.
A kind of preparation method of Moringa composite particles agent, includes the following steps:
(1) it extracts
It takes dry leaf of Moringa, Roselle calyx by solid-liquid ratio 1kg ︰ (6~25) L extracting in water, is heated at 50 DEG C~100 DEG C
It extracts 1~3 time, extracts 0.5~2h (set temperature is raised to Extracting temperature and starts timing) every time, obtain leaf of Moringa, roselle
Extracting solution；Moringa leaf extract or roselle extract can also be prepared respectively by above-mentioned steps；
Brazilian certain kind of berries fruit powder is taken to extract by solid-liquid ratio 1kg ︰ (5~25) L extracting in water in 50 DEG C~100 DEG C heating extractions
0.3~2h (is raised to set temperature with Extracting temperature and starts timing), obtains Brazilian certain kind of berries extracting solution；
(2) to step (1) obtain Moringa leaf extract, roselle extract, Brazilian certain kind of berries extracting solution purified, be concentrated,
It is dry, obtain leaf of Moringa extract powder, roselle extract powder, Brazilian certain kind of berries extract powder；
(3) the Moringa composite particles agent is prepared by following either method:
1. the leaf of Moringa extract powder that step (2) is obtained, roselle extract powder, Brazilian certain kind of berries extract powder and auxiliary materials and mixing, are adopted
Moringa composite particles agent is made with wet granulation；
2. by step (1) obtain Moringa leaf extract, roselle extract, Brazilian certain kind of berries extracting solution are purified, are concentrated,
Auxiliary material is added, Moringa composite particles agent is made using spray-drying process.
The Extracting temperature of leaf of Moringa described in step (1), roselle or the Brazilian certain kind of berries is preferably 50 DEG C~80 DEG C；Further
Preferably 60 DEG C~70 DEG C.
Leaf of Moringa described in step (1) or the solid-liquid ratio of roselle are preferably 1kg ︰ (10~25) L, further preferably
1kg ︰ (15~25) L.
The solid-liquid ratio of the Brazilian certain kind of berries described in step (1) is preferably 1kg ︰ (10~25) L, further preferably 1kg ︰ (20
~25) L.
The time of the extraction of leaf of Moringa or roselle described in step (1) is preferably 1~1.5h.
The extraction time of the Brazilian certain kind of berries described in step (1) is preferably 1~2h.
Water described in step (1) is preferably purified water, distilled water, qualified drinking water or deionized water.
The concrete operations of purifying described in step (2) can for it is following any one:
1. filtering Moringa leaf extract, roselle extract, Brazilian certain kind of berries extracting solution, stand 36 in 2~4 DEG C (not freezing)~
60h takes supernatant；
2. will with Moringa leaf extract, roselle extract, Brazil 8000~16000rpm of the certain kind of berries extracting solution centrifugation 10~
30min takes supernatant to get the Moringa leaf extract after purification, roselle extract, Brazilian certain kind of berries extracting solution.
The time of the standing is preferably 48h.
Moringa leaf extract after purification, roselle extract, Brazilian certain kind of berries extracting solution density be preferably 1.1~1.12.
The concrete operations of concentration described in step (2) are as follows:
In the state that vacuum degree is -0.03~0.08MPa, temperature is 70 DEG C~92 DEG C, it is concentrated under reduced pressure into relative density
For be at 20 DEG C 1.3~1.35 to get concentration after extract.
Drying described in step (2) is preferably dried under reduced pressure, further preferably following any operation:
1. by the extract after concentration -10 DEG C~-80 DEG C pre-freezes for 24 hours, then vacuumize freeze-drying to moisture≤
5.0%；
2. being dried under reduced pressure at 55 DEG C~70 DEG C of temperature to moisture≤5.0%.
Leaf of Moringa extract powder described in step (3), roselle extract powder, Brazilian certain kind of berries extract powder preferably in mass ratio (4~
8): (1~2): (1~4) proportion.
Auxiliary material described in step (3) is preferably Icing Sugar, stevioside, mannitol, lactose, beta-cyclodextrin and soluble starch
In at least two；Further preferably Icing Sugar, mannitol, stevioside, soluble starch.
The Icing Sugar, mannitol, stevioside, soluble starch (0.5~2) preferably in mass ratio: (3.5~10):
(0.15~0.5): (1~2) is matched.
Leaf of Moringa extract powder described in step (3), roselle extract powder, the gross mass of Brazilian certain kind of berries extract powder and auxiliary material are excellent
Choosing 1:(1~2.2 in mass ratio) proportion.
The step of wet granulation described in step (3) specifically: by leaf of Moringa extract powder, roselle extract powder, Brazil
Certain kind of berries extract powder and auxiliary materials and mixing are added solvent and softwood, granulation, drying are made.
The solvent is preferably the ethanol solution that concentration is percent by volume 65~80%, further preferably volume hundred
Divide the ethanol solution than being 65%~75%.
The dosage of the solvent preferably presses solvent and total extract powder amount (leaf of Moringa extract powder, roselle extract powder, Brazil
The gross mass of certain kind of berries extract powder)=(1~2.5) L:(1~4.5) Kg matched, further preferably (1~1.5) L:(3~
4.5)Kg。
The Moringa composite particles agent as made from the preparation method, can largely retain its efficacy activity at
Point, and favorable solubility, absorption is fast and complete, and taste flavor is superior, sour-sweet middle band nature fragrance, and product colour is beautiful,
Granula is in rose-red after brewing, and color is beautiful.
A kind of compound pressed candy of Moringa, includes the Moringa composition and auxiliary material.The compound pressed candy of the Moringa
Particle water content is not higher than 6% in fruit, and tablet weight variation limit is ± 5.0%, and disintegration time limited is no more than 30min.
The preparation method of the compound pressed candy of the Moringa, by tabletting system after the Moringa composition and auxiliary materials and mixing
?.
The Moringa composition is in preparation prevention or food or the health care of adjuvant treatment hyperlipidemia and atherosclerosis
Application in food.
The present invention has the following advantages and effects with respect to the prior art:
(1) it the present invention provides a kind of Moringa composition, is innovatively all had jointly using efficacy activity and chemical component
The Brazilian certain kind of berries, roselle and the leaf of Moringa selected are combined, and can be learnt from other's strong points to offset one's weaknesses and be acted synergistically.In chemical component, three
Person has polysaccharide and flavones ingredient；It functionally, can anti-oxidant, reduction cholesterol and triglycerides, reduction low density lipoprotein
The effect of albumen, increasing high density lipoprotein is the reasonable combination for preventing and treating the cardiovascular and cerebrovascular diseases such as atherosclerosis.In flavour
On, Moringa extract band is pungent, astringent taste, acai berry extract taste mellowness, roselle extract because being in tart flavour rich in citric acid,
After three's combination, tart flavour can cover the bitterness and pungent of leaf of Moringa, can by the way that appropriate corrigent such as Icing Sugar or stevioside etc. is added
Make composition that sweet and sour taste and attached fragranced be presented.From appearance and color, the Brazilian certain kind of berries and roselle institute is presented solely in solution
Special rose-red, it is beautiful in colour.Three combines from effect, mouthfeel and appearance color, shows the excellent of natural, healthy solid beverage
Good combination.Importantly, they belong to excellent dual-purpose of drug and food new resource food, integrate nutrition, healthcare function, pole
It is suitble to the prevention and treatment of " modern disease ", for improving function of human body and sub-health state.
(2) the present invention also provides the granules and pressed candy that contain the Moringa composition, have norcholesterol
Therefore it can be used for improving dyslipidemia, the artery congee of prevention hyperlipidemia induction with triglyceride, drop LDL and oxidation resistant effect
Sample hardenability disease.The Brazilian certain kind of berries, roselle and the optimized technique of leaf of Moringa are extracted, and are processed into granule and pressed candy,
It is the concentration of three kinds of new resource foods, smaller dosage can reach efficacy effect, after having milling, Ultramicro-powder (fecula) or milling
Tabletting such as swallows at the incomparable advantage of application methods.Secondly, granule and pressed candy are small in size, it is convenient for carrying transport,
Storage tolerance, easy to use, taste flavor is superior, sour-sweet middle band nature fragrance, and product colour is beautiful, granule brew after in rose
Red, color is beautiful, is easily liked by people, overcomes and is difficult to entrance hypopharynx existing for the application methods such as milling or milling tabletting
The shortcomings that；Again, it after composition is processed into granule and pressed candy, is suitable for industrialized large-scaled production, stable product quality can
Control overcomes product quality that fecula direct tablet compressing occurs and is difficult to control and unstable problem.
(3) the present invention also provides the preparation method of the Moringa composition, granule, pressed candy, simple processes
And stablize, cost is relatively low, has good industry promotion prospect.
Detailed description of the invention
Fig. 1 is rutin standard curve figure (520nm).
Fig. 2 is the flavones content result analysis chart for the roselle extract that different Extracting temperatures obtain.
Fig. 3 is different feed liquid than the flavones content result analysis chart of obtained roselle extract.
Fig. 4 is the flavones content result analysis chart for the roselle extract that different extraction times obtain.
Fig. 5 is the flavones content result analysis chart of the roselle extract obtained different extraction times.
Fig. 6 is the flavones content result analysis chart of the acai berry extract obtained different extraction times.
Fig. 7 is different feed liquid than the flavones content result analysis chart of obtained acai berry extract.
Fig. 8 is the flavones content result analysis chart for the acai berry extract that different Extracting temperatures obtain.
Fig. 9 is rutin standard curve figure (510nm).
Specific embodiment
Present invention will now be described in further detail with reference to the embodiments and the accompanying drawings, but embodiments of the present invention are unlimited
In this.
The foundation of the measuring method of 1 sample general flavone content of embodiment
1. the preparation of rutin standard curve
0.0100g rutin standard items are accurately weighed, is dissolved in 100mL distilled water, is placed in brown volumetric flask, with ultrasound
It is dissolved, becomes the rutin standard solution of 0.1mg/mL.Respectively take 0.0,1.0,2.0,3.0,4.0,5.0mL titer is in test tube
In, respectively plus distilled water 5mL；After 5%NaNO is added2Solution 0.5mL stands 5min, 10%AlCl3Solution 0.5mL stands 5min；
4%NaOH solution 4mL is added, stands 10min.The absorbance value of rutin standard solution is measured under 520nm wavelength.
1 rutin concentration of table and absorbance value table
| Rutin content (mg) | 0.0 | 0.1 | 0.2 | 0.3 | 0.4 | 0.5 |
| Absorbance value | 0 | 0.067 | 0.129 | 0.184 | 0.255 | 0.328 |
Rutin standard curve is as shown in Figure 1, do scatter plot with this, and linear fit obtains: y=0.6431x, R2=0.9982,
Correlation is good.
2. the measuring method of flavones
The tested extracting solution of 0.1mL is taken, 5mL distilled water is added, adds 0.5mL 5%NaNO2, stand 6min.Plus 0.5mL then
10%Al (NO3)3, oscillation, standing 6min.Add 4mL 1mol/L NaOH, after standing 10min, in 520nm ultraviolet specrophotometer
Under measure its absorbance.
2 roselle Study on extraction of embodiment
1. the single factor exploration of extraction process
(1) influence of the Extracting temperature to recovery rate
3.00g roselle powder is weighed, using water as solvent, with the solid-liquid ratio of 1:15, respectively at 50 DEG C, 60 DEG C, 70 DEG C, 80 DEG C
Lower heating and refluxing extraction respectively is primary, return time 0.5h.Then it filters while hot, gained filtrate is centrifuged with 8000r/min
10min, taking supernatant is roselle extract.
Influence of the different Extracting temperatures of table 2 to roselle flavones content
By table 2, Fig. 2 it is found that using the content of flavones height as the inspection target of recovery rate, each extraction time is 0.5h
When, as a result, it has been found that, roselle Aqueous extracts flavones content highest at 60 DEG C of Extracting temperature, therefore, selecting 60 DEG C is most suitable extraction temperature
Degree.
(2) influence of the solid-liquid ratio to recovery rate
3.00g roselle powder is weighed, is taken water as a solvent, respectively with the solid-liquid ratio of 1:10,1:15,1:20,1:25, at 60 DEG C
Lower heating and refluxing extraction 1.5h respectively.Then it filters while hot, gained filtrate is centrifuged 10min at 8000r/min, takes the supernatant to be
Roselle extract.
3 solid-liquid ratio of table proposes the influence of roselle flavones content to water
By table 3, Fig. 3 it is found that as solid-liquid ratio increases, the flavones content of roselle extract rises, when solid-liquid ratio is 1:
There is peak value in flavones content when 15, continues thereafter with increase solid-liquid ratio, and flavones content no longer increases, and therefore, chooses roselle: water
Ratio is that 1:15 is most suitable solid-liquid ratio.
(3) influence of the extraction time to recovery rate
3.00g roselle is weighed, is taken water as a solvent, with the solid-liquid ratio of 1:15, is heated to reflux 1,2,3 respectively at 60 DEG C
It is secondary, each extraction time 1.5h.Then it filters while hot, gained filtrate is centrifuged 10min at 8000r/min, and taking supernatant is rose
Rare eggplant extracting solution.
Influence of 4 extraction time of table to roselle flavones content
As a result as shown in table 4, Fig. 4, with the increase of extraction time, the flavones content of roselle extract rises, when mentioning
Take number be 2 times when, extracting solution flavones content reaches peak value, continue growing extraction time flavones content decline, therefore, choose 2
Secondary is most suitable extraction time.
(4) influence of the extraction time to recovery rate
3.00g roselle powder is weighed, is taken water as a solvent, with the solid-liquid ratio of 1:15 at 60 DEG C, is heated to reflux 2 times, every time
Return time is respectively 0.5h, 1.0h, 1.5h, 2.0h.Then it filters while hot, gained filtrate is centrifuged at 8000r/min
10min, taking supernatant is roselle extract.
Influence of 5 extraction time of table to roselle flavones content
As a result as shown in table 5, Fig. 5, as extraction time increases, flavones content is increased in roselle extract, works as extraction
Time reaches maximum when being 1.5h, continue to increase extraction time, and the decline of roselle flavones content, therefore, it is best for choosing 1.5h
Extraction time.
2. extraction process orthogonal test
6 orthogonal test factor level table of table
The orthogonal experiments and analysis of 7 roselle extraction process by water of table
It can be seen that optimum extraction process combination from orthogonal experiments analytical table are as follows: 60 DEG C of Extracting temperature, extraction time
1 time, extraction time 1.5h, solid-liquid ratio 1:15.
3. sample recovery rate is tested
8 sample recovery rate experimental result of table
Medicinal material 3.0005g is weighed, as shown in Table 8, sample recovery rate shows that method measurement is yellow between 95%~105%
The content of ketone is accurate, reliable.
4. stability experiment
9 stability experiment result of table
By Optimized extraction techniques A1B2C3D2, 3 batches are verified, general flavone content is respectively 25.667mgg in extract-1、
25.968mg·g-1、25.806mg·g-1, show that the process stabilizing is feasible.
The Brazilian certain kind of berries Study on extraction of embodiment 3
1. extraction process single factor exploration
(1) influence of the extraction time to recovery rate
1.00g Brazil certain kind of berries freeze-dried fruit powder is weighed, using water as solvent, with the solid-liquid ratio of 1:20, is heated back respectively at 60 DEG C
Stream extracts 0.5h, 1h, 1.5h, 2h.Then it filters while hot, gained filtrate is centrifuged 10min in 8000r/min, takes supernatant.Using
Ultraviolet specrophotometer surveys solution absorbance value with 520nm wavelength.
Influence of 10 extraction time of table to Brazilian certain kind of berries flavones content
As a result as shown in table 10, Fig. 6, as extraction time increases, flavones content increases in Brazilian certain kind of berries extracting solution, extracts 1h
When gained flavones content be noticeably greater than 0.5h, extraction time be 1.5h after reach relatively stable, therefore, selections 1h is optimum extraction
Time.
(2) influence of the solid-liquid ratio to recovery rate
1.50g Brazil certain kind of berries powder is weighed, using water as solvent, respectively with the solid-liquid ratio of 1:5,1:10,1:15,1:20,1:25,
Heating and refluxing extraction 1h is distinguished at 60 DEG C.Then it filters while hot, gained filtrate is centrifuged 10min at 8000r/min, takes supernatant
For Brazilian certain kind of berries extracting solution.Ultraviolet specrophotometer surveys absorbance value with 520nm wavelength.
Influence of 11 solid-liquid ratio of table to Brazilian certain kind of berries flavones content
As a result as shown in table 11, Fig. 7, as solid-liquid ratio increases, flavones content increases in Brazilian certain kind of berries Aqueous extracts, works as solid-liquid ratio
When for 1:20, flavones content is noticeably greater than solid-liquid ratio when being 1:15, hereafter reaches relatively stable, therefore, it is best for choosing 1:20
Solid-liquid ratio.
(3) influence of the Extracting temperature to recovery rate
1.00g Brazil certain kind of berries powder is weighed, is taken water as a solvent, with the solid-liquid ratio of 1:20, respectively at 50 DEG C, 60 DEG C, 70 DEG C, 80 DEG C
Lower heating and refluxing extraction 1h respectively.Then it filters while hot, gained filtrate is centrifuged 10min at 8000r/min, and taking supernatant is bar
Western certain kind of berries extracting solution.Ultraviolet specrophotometer is used to survey absorbance value with 520nm.
Influence of 12 Extracting temperature of table to Brazilian certain kind of berries flavones content
As a result as shown in table 12, Fig. 8, as Extracting temperature is promoted, flavones content increases in Brazilian certain kind of berries Aqueous extracts, works as extraction
When temperature is 60 DEG C, flavones content is apparently higher than 50 DEG C of Extracting temperature, continues raising Extracting temperature flavones content and declines instead, because
This, chooses 60 DEG C preferably as most suitable Extracting temperature.
2. extraction process orthogonal test
13 orthogonal test factor level table of table
The orthogonal experiments and analysis of the Brazilian certain kind of berries extraction process by water of table 14
By range analysis of orthogonal experiment it is found that extraction process by water optimum organization is A1B1C2, i.e. Extraction technique is when extracting
Between 30min, solid-liquid ratio 1:20,60 DEG C of Extracting temperature.
3. sample recovery rate is tested
15 sample recovery rate experimental result of table
Medicinal material 3.0041g is weighed, as shown in Table 15, sample recovery rate shows that method measurement is yellow between 95%~105%
The content of ketone is accurate, reliable.
4. stability test
16 stability experiment result of table
By Optimized extraction techniques A1B1C2, 3 batches are verified, general flavone content is respectively 4.63mgg in extract-1、
4.31mg·g-1、4.61mg·g-1, show that the process stabilizing is feasible.
4 leaf of Moringa Study on extraction of embodiment
4.1 extraction process by water orthogonal tests
The experiment of single factor mentioned according to water determines and investigates Extracting temperature A, extraction time B, solid-liquid ratio C, extraction time D tetra-
A factor designs L9(3)4Orthogonal test factor level table.
17 quadrature factor water-glass of table
The detection of 4.2 dry extracts
It is carried out according to orthogonal test table, extracting solution concentration takes 40mL sample liquid in 75mL evaporating dish, is placed in baking oven and evaporates
To doing, in weighing on electronic balance, data are recorded.Remaining sample liquid keeps sample preservation.
18 dry cream measurement result of table
4.3 sample determination of total flavonoids
4.3.1 rutin standard curve is established
Serial solution is prepared in " preparations of 1. rutin standard curves " identical method in embodiment 1, under 510nm wavelength
Measure absorbance value.
19 standard curve data record of table
By measurement result, cast out improper data (0.8,0.729), and scatter plot (Fig. 9) is done with this, linear fit obtains: Y
=0.8709X, R2=0.9994.
4.3.2 determination of total flavonoids result
Sample liquid respectively takes 0.1mL in test tube, adds distilled water to 5mL, 5%NaNO is similarly added2Solution 0.5mL is stood
5min, 10%AlCl3Solution 0.5mL stands 5min, 4%NaOH solution 4mL, stands 10min, measures and inhales under 510nm wavelength
Shading value is received, and general flavone percentage composition is calculated by standard curve.
According to weight distribution, calculated just according to general flavone content (accounting for weight 0.6) and dry extract yield (accounting for weight 0.4)
Hand over the comprehensive score of test, it is alternatively that one of basis of optimal experimental program.
Comprehensive score=dry extract yield/(highest dry extract yield × 0.4 × 10)+flavones content/(highest flavones content
×0.6×10)
20 orthogonal experiments of table and intuitive analytical table
21 orthogonal test analysis of variance table of table
By range analysis result it is found that the influence power sequence of each factor are as follows: D extraction time > B extraction time > C solid-liquid ratio > A
Extracting temperature.On the other hand, by intuitively analyzing it is found that optimum combination is: 60 DEG C of Extracting temperature, 1h, solid-liquid ratio 1:20 are extracted,
It extracts 3 times.
Purifying, concentration and the drying process of 5 extracting solution of embodiment
1. purifying process
(1) method one: by obtained leaf of Moringa, roselle, the filtration of Brazilian certain kind of berries Aqueous extracts, filtrate is sieved with 100 mesh sieve, then in
2~4 DEG C (should not freeze) standing 48h, take supernatant, 1.1~1.12 be with density it is best, be collected in receiver, it is spare.
(2) method two: by obtained leaf of Moringa, roselle, Brazilian certain kind of berries Aqueous extracts with 8000~16000rpm centrifugation 10~
30min takes supernatant, 1.1~1.12 be with the density of extracting solution it is best, be collected in receiver, it is spare.
2 concentration technologies
In being concentrated in external circulation evaporator.Concentration technology parameter: being -0.03~0.08MPa, temperature 70 in vacuum
DEG C~92 DEG C in the state of, being concentrated under reduced pressure into relative density to be at 20 DEG C is 1.300~1.350, collects medicinal extract and holds in cleaning
In device, material label is sticked, it is spare.
3 drying process
(1) method one: in drying room, moving to -10 DEG C~-80 DEG C pre-freezes for 24 hours for medicinal extract, and it is dry to be then transferred to vacuum refrigeration
In dry machine, freeze-drying is vacuumized for 24 hours to moisture≤5.0%, receives dry cream, storage.By load weighted dry cream pulverizer by its
80 mesh powder are ground into, are collected spare.
(2) method two: taking medicinal extract to be laid in vacuum oven in right amount, in 55 DEG C~70 DEG C dryings of temperature to moisture≤
5.0%, collect dry cream, storage.Load weighted dry cream is ground into 80 mesh powder with pulverizer, is collected spare.
By purifying, being concentrated above and corresponding medicinal extract is made in leaf of Moringa, roselle, Brazilian certain kind of berries Aqueous extracts by drying process
Powder carries out follow-up study.
6 composite formula screening study of embodiment
1. recipe determination
The formula combination of table 22 different auxiliary material and extract powder
The taste of prescription 8 by taste screening is best.Specified amount leaf of Moringa, the Brazilian certain kind of berries, rose are taken by prescription 8 in table 22
Total auxiliary material amount 1:2 in mass ratio such as the total medicinal extract amount of eggplant and Icing Sugar, mannitol, stevioside, starch is mixed, using 70% ethyl alcohol conduct
Solvent, according to amount of alcohol: total medicinal extract amount (leaf of Moringa+Brazil's certain kind of berries+roselle)=(1~1.5) L:(3~4.5) Kg, using wet process
Granulation obtains composition granule.The product of wet granulation is relatively strong with good appearance, good fluidity, wearability, is compressed into
The advantages that shape is good.According to auxiliary material and extract powder be mixed evenly to prepare the hygroscopicity of particle, mouldability, melting, heap density and
Angle of repose selects appropriate auxiliary material.
Take prescription content of starting materials to extract by the optimum extraction process preferably gone out, removal of impurities, after concentration, dry dry extract is pressed
22 prescription of table takes specified amount extract powder and auxiliary materials and mixing, measures mouldability, heap density, angle of repose and the suction of composition granule
It is moist, and using mouldability, heap density, angle of repose and hygroscopicity as index comprehensive evaluation, as a result preferably best auxiliary material is tested
Standard is carried out according to shown in formula (2).
Overall target=(20 ÷ maximum mouldability value) × mouldability value+(20 ÷ most raft density value) × heap density value+
(minimum angle value of stopping × 20) ÷ angle value of stopping+(minimum hydroscopicity value × 40) ÷ hydroscopicity value ... formula (2)
The design of the prescription compatibility of medicines of 23 different auxiliary material of table and extract powder
2. the measurement of mouldability
The particle prepared is weighed, No.1 sieve (10 mesh) is first crossed, after No. four sieves (65 mesh), one can be passed through by collecting
Number sieve but cannot pass through No. four sieve particles, weighing.Mouldability is calculated according to formula (3) and (4), and measurement result is shown in Table 24.
Granular mass × 100% ... formula (3) before granular mass ÷ is sieved after ratio of briquetting=sieving
Mouldability score value=(20 ÷ maximum mouldability value) × mouldability value ... formula (4)
The measurement of the mouldability of 24 composition granule of table
3. the measurement of heap density
Heap density is also known as apparent density or bulk density, means the quality of unit volume particle.Volume used in heap density is
Refer to the total volume between particle and itself gap and particle and particle including gap.The heap density of particle is heap volume greatly
It is small, can indicate the close degree of particle and determine volume divided dose number.Particle after sieving is put into dry graduated cylinder
In, it gently vibrates, reads the mL number (V) at its nearly scale；Using the quality after sieving as M (g), the ratio of the two is that heap is close
Degree.The calculating of heap density score value is carried out according to formula (5), and the result is shown in tables 25.
Heap density score value=(20 ÷ most raft density value) × heap density value ... formula (5)
Wherein,
The measurement of the heap density of the Brazilian certain kind of berries leaf of Moringa composition granule of table 25
4. the measurement at angle of repose
Mobility is one of critical nature of granule, the accuracy of the quality and the quality, divided dose of particle of mobility
Related, turnover rate and angle of repose are commonly used in pharmacy to be indicated.Angle of repose is smaller, and mobility is better.Usual partial size is smaller or granularity
It is distributed wide particle, it is bigger that body stops angle；And partial size is round, big and uniform particle easily flows, angle of repose is small.
Using fixed funnel method, 3 funnels are connected and are fixed on horizontal positioned graph paper at the height of 1cm, it is small
Heart is poured into particle along hopper walls in the funnel on most until the particle cone tips formed on graph paper touch funnel
Until mouthful, the diameter (2R) of conical base is measured by graph paper, calculates angle of repose tga=H/R, is done 3 times, calculate average value.
Angle of repose score value is calculated according to formula (6), and result is as shown in table 26.
Angle of repose score value=(minimum angle of repose × 20) angle of repose ... ÷ formula (6)
Wherein, angle of repose
The angle of repose measurement result of the Brazilian certain kind of berries leaf of Moringa composition granule of table 26
5. hygroscopic measurement
A certain amount of granule is taken, constant weight in 40 DEG C of baking ovens is set, bottom is placed with to the glass desicator of NaCl saturated solution
Middle timing is put into NaCl until forming NaCl supersaturated solution, and the relative humidity in drier is 75% at this time.In constant weight
Flat weighing bottle bottom is put into the granule of 2mm, and correct amount is placed in above-mentioned drier (flat weighing bottle opening).Claim after 48h
Amount calculates moisture absorption percentage.Two groups are done altogether, calculate average value.Hygroscopicity is calculated according to formula (7) and (8), test result
As shown in table 27.
Weight × 100% ... formula (7) before Moisture percentage %=(weight before weight-moisture absorption after moisture absorption) ÷ moisture absorption
Hydroscopicity score value=(minimum hydroscopicity value × 40) ÷ hydroscopicity value ... formula (8)
The hygroscopicity measurement result of the Brazilian certain kind of berries leaf of Moringa composition granule of table 27
The overall merit of the Brazilian certain kind of berries leaf of Moringa composition grain of table 28
For the overall merit of preparations shaping technique according to formula (2), result is as shown in table 28.As can be known from Table 28, optimal
Ratio of adjuvant scheme is prescription 3, it is, leaf of Moringa extract powder: roselle extract powder: Brazilian certain kind of berries extract powder: Icing Sugar: sweet dew
Alcohol: stevioside: soluble starch=10:2.5:5:5:20:1:7.5.
The preparation of 7 composition granule of embodiment
1 granulation, dry, whole grain
(1) method one, wet granulation: take suitable auxiliary material (auxiliary material can be referred to as Icing Sugar, stevioside, mannitol, lactose,
It is a variety of in beta-cyclodextrin, soluble starch, be best with Icing Sugar, mannitol, stevioside, soluble starch), 80 meshes are crossed,
It collects.Leaf of Moringa, roselle after taking above-mentioned sieving, Brazilian certain kind of berries extract powder, Icing Sugar, mannitol, stevioside, soluble starch by
Mass ratio 10:2.5:5:5:20:1:7.5 recipe quantity, accurately weighs, pours into trough type mixing machine, is uniformly mixed, by per kilogram plus
Enter the ethyl alcohol 1.5L softwood of percent by volume 70~80%, softwood is placed in oscillating granulator and crosses the granulation of 14 meshes, and setting is suitable
Suitable inlet air temperature makes temperature of charge keep 50 DEG C~60 DEG C dryings, makes material to moisture≤5.0%, collects, dry particl whirlpool
Vibration sieve 10 mesh/65 mesh sieves, are collected to get particle.
(2) method two, spray-drying process: first controlling concentrate precooling temperature 2~4 DEG C or so (not freezing), quiet
48h is set, supernatant is taken, the auxiliary material of recipe quantity is added, carries out spray-drying process.Drying process with atomizing parameter: inlet temperature
170 DEG C~190 DEG C, 80 DEG C~90 DEG C of outlet temperature.
2 inner packings
Between packing, granule after the assay was approved is taken, is dispensed, is collected.The finished product dispensed is packed into vacuum bag and puts in storage.
The preparation of 8 composition granule of embodiment
It takes and suitable auxiliary material is claimed to cross 80 meshes, collect.Leaf of Moringa, roselle after taking above-mentioned sieving, Brazilian certain kind of berries extract powder,
Icing Sugar, stevioside, mannitol, starch 8:2:2:2:1:8:4 in mass ratio are accurately weighed, and are poured into trough type mixing machine, and mixing is equal
It is even, ethyl alcohol 2.5L, 2L, 1L softwood of percent by volume 65%, 70%, 75% is separately added by per kilogram, softwood, which is placed in, to be shaken
Pendulum-type granulator crosses the granulation of 14 meshes, sets suitable inlet air temperature, so that temperature of charge is kept 50 DEG C~60 DEG C dryings, makes material
It to moisture≤5.0%, collects, dry particl is shaken with whirlpool sieves 10 mesh/65 mesh sieves, collects to get particle.
The present embodiment, as solvent, can obtain satisfactory granule, particle using the ethanol solution of various concentration
Agent color masks the brown of leaf of Moringa itself well, shows reddish violet；Mouthfeel also masks the bitterness of leaf of Moringa itself
Taste, mouthfeel are the sour-sweet taste for being easier to be accepted.Wherein, the ethanol solution that concentration is 70% is more preferably.
The preparation of 9 composition granule of embodiment
It takes and suitable auxiliary material is claimed to cross 80 meshes, collect.Leaf of Moringa, roselle after taking above-mentioned sieving, Brazilian certain kind of berries extract powder,
Icing Sugar, stevioside, mannitol, starch 8:2:4:2:1:(16~20 in mass ratio): 4 accurately weigh, and pour into trough type mixing machine,
It is uniformly mixed, is separately added into ethyl alcohol 2.5L, 2L, 1L softwood that percent by volume is 65%, 70%, 75% by per kilogram, it is soft
Material is placed in oscillating granulator and crosses the granulation of 14 meshes, sets suitable inlet air temperature, and temperature of charge is made to be kept for 50 DEG C~60 DEG C do
It is dry, make material to moisture≤5.0%, collects, dry particl is shaken with whirlpool sieves 10 mesh/65 mesh sieves, collects to get particle.
In the formula, good granule can be made in the ethanol solution of various concentration, wherein the second that concentration is 70%
Alcoholic solution is more preferably.The dosage for increasing Brazilian certain kind of berries extract powder, since its density is smaller, hygroscopicity becomes smaller, while can not be well
Lyosoption and other substances are bonded, therefore starch used in amounts will increase.Granule color made from the present embodiment becomes
Pink colour more highlights the color of Brazilian certain kind of berries dry cream.
The preparation of 10 composition pressed candy of embodiment
1. extraction purification: learning from else's experience and examine qualified drying leaf of Moringa, Roselle calyx, weighing passes through throwing by a certain percentage
Material mouth is put into multi-function extractor, and is added into extractor by the solid-liquid ratio of 1kg ︰ (6~20) L (quality and volume ratio) pure
Change water, distilled water or qualified drinking water, 60 DEG C~100 DEG C heating extraction 1~3 time, extract 1~1.5h every time (with Extracting temperature
It is raised to set temperature and starts timing), extracting solution is filtered through 100 meshes, then in 2~4 DEG C (not freezing) standing 48h, takes supernatant
Liquid, merges supernatant, the relative density of extract 1.1~1.12 be it is best, obtained leaf of Moringa roselle extract is collected in
It is spare in receiver.Leaf of Moringa and roselle can extract respectively according to process above, also combinable to extract simultaneously.
Brazilian certain kind of berries fruit powder is individually extracted, and is added by the solid-liquid ratio (quality and volume ratio) of 1kg ︰ (6~20) L into extractor
Purified water, distilled water or qualified drinking water, 60 DEG C~80 DEG C heating extraction 1 time, extract 0.3~1h every time (with Extracting temperature liter
Start timing to set temperature), remaining operation is the same.
2. concentration: extracting solution, which is transferred in multiple-effect external circulation evaporator, in extraction receiver is concentrated.Concentration technology ginseng
Number: in the state that vacuum is -0.03MPa~-0.06MPa, temperature is 70~92 DEG C, being concentrated under reduced pressure into relative density is
1.300~1.350 (20 DEG C), obtain medicinal extract, collect medicinal extract in clean container, sticking material label, spare.
3. dry: medicinal extract being moved to -10 DEG C~-80 DEG C freezings for 24 hours, is then transferred in vacuum drier, vacuumizes cold
Be lyophilized it is dry obtain dry cream for 24 hours, receive dry cream.Load weighted leaf of Moringa, roselle, Brazilian certain kind of berries dry cream are crushed with pulverizer
At 80 mesh dried cream powders, collect spare.
4. moulding process
(1) pelletize, be dry, whole grain: using wet granulation, take the auxiliary material after weighing (auxiliary material can for Icing Sugar, stevioside,
It is mannitol, lactose, beta-cyclodextrin, a variety of in soluble starch), 80 meshes are crossed, are collected.Leaf of Moringa after taking above-mentioned sieving,
Roselle, Brazilian certain kind of berries extract powder, Icing Sugar, mannitol, stevioside, soluble starch are 10:5:5:2.5:12.5:1 with mass ratio:
5 amount mixing, accurately weighs, pours into trough type mixing machine, be uniformly mixed, and 70~80% concentration of 1.5L volume is added by per kilogram
Ethyl alcohol softwood, softwood be placed in oscillating granulator cross 14 meshes granulation, set suitable inlet air temperature, protect temperature of charge
Hold 50 DEG C~60 DEG C dryings, until moisture≤5.0%, collect, dry particl whirlpool shakes sieve 10 mesh/60 mesh sieves, collect to get bar
Western certain kind of berries leaf of Moringa composition grain.
(2) tabletting: taking above-mentioned particle to cross 14 meshes, in 50~60 DEG C of dryings, 12 mesh sieves is crossed, by 0.3% (w/ of dosage
W)~1% magnesium stearate is added in (w/w), is first uniformly sprinkled into appropriate, mixing, remaining afterwards to be all added, and mixes well, weighs, counts
Calculate slice weight, tabletting, every 0.5~0.8g.Particle water content is not higher than 6% in piece, and tablet weight variation limit is ± 5.0%,
Disintegration time limited is no more than 30min, and Brazil's certain kind of berries Moringa leaf composition pressed candy is made.
5. inner packing: between packing, taking the qualified tablet after polishing, dispense, collect.The finished product dispensed is packed into leatheroid cylinder
It puts in storage.
Comparative example 1
It takes and suitable auxiliary material is claimed to cross 80 meshes, collect spare.Leaf of Moringa, roselle, Brazilian certain kind of berries leaching after taking above-mentioned sieving
Cream powder, stevioside, microcrystalline cellulose 4:1:1:2:4 in mass ratio are accurately weighed, and are poured into trough type mixing machine, are uniformly mixed, point
Not Jia Ru concentration of volume percent be 70%, 75%, 80% ethyl alcohol 1.5L, 1.0L, 0.8L softwood, softwood is placed in swing
Granulator crosses the granulation of 14 meshes, sets suitable inlet air temperature, so that temperature of charge is kept 50 DEG C~60 DEG C dryings, makes material to water
Divide≤5.0%, collect, dry particl is shaken with whirlpool sieves 10 mesh/65 mesh sieves, collects to get particle.
Test result shows, uses 80% ethyl alcohol for solvent it can be concluded that the preferable granule of dosage form, but microcrystalline cellulose
Plain poorly water-soluble, when later period grain dissolution, generate a large amount of floccules, do not meet requirement of the National Pharmacopeia to granule.
Since the bitter taste that leaf of Moringa itself has is heavier, roselle is only added, the Brazilian certain kind of berries can only cover the face of leaf of Moringa
Color but its taste can not be covered, the present embodiment selects the very strong stevioside of sugariness (sugariness be about sucrose 300 times) to cover
The bitter taste of leaf of Moringa, but since stevioside sugariness is big, mouthfeel (the stevioside mistake for the change particle that lesser dosage will be very big
Bitter taste can mostly be generated), it is unable to get have both taste flavor superior, sour-sweet middle band nature fragrance, the granule of product colour beauty.
Comparative example 2
It takes and suitable auxiliary material is claimed to cross 80 meshes, collect spare.Leaf of Moringa, roselle, Brazilian certain kind of berries leaching after taking above-mentioned sieving
Cream powder, Icing Sugar: stevioside: mannitol 8:2:2:2:1:16 in mass ratio is accurately weighed, and is poured into trough type mixing machine, and mixing is equal
It is even, by per kilogram be separately added into concentration of volume percent be 65%, 70%, 75%, 80% ethyl alcohol be respectively 2.5L, 2.0L,
1.5L, 1.0L softwood, softwood are placed in oscillating granulator and cross the granulation of 14 meshes, set suitable inlet air temperature, make material temperature
Degree keeps 50 DEG C~60 DEG C dryings, makes material to moisture≤5.0%, collects.
The study found that bonding excessively can not seriously pelletize, but 70% second when the ethyl alcohol using 65% is as solvent
Adhesiveness is poor when alcohol is as solvent, is unable to get the particle of standard dosage forms.
Comparative example 3
It takes and suitable auxiliary material is claimed to cross 80 meshes, collect spare.Leaf of Moringa, roselle, Brazilian certain kind of berries leaching after taking above-mentioned sieving
Cream powder, Icing Sugar, stevioside, mannitol, starch 8:4:2:2:1:(16~20 in mass ratio): 4 accurately weigh, and pour into groove profile mixing
In machine, it is uniformly mixed, the ethyl alcohol of 65%, 70%, 75%, 80% concentration of concentration of volume percent is separately added by per kilogram
2.0L, 1.5L, 1.0L softwood, softwood are placed in oscillating granulator and cross the granulation of 14 meshes, set suitable inlet air temperature, make object
Material temperature degree keeps 50 DEG C~60 DEG C dryings, makes material to moisture≤5.0%, collects.
In this comparative example, attempted the ethyl alcohol of various concentration as solvent, but the ethyl alcohol of all concentration be all so that
Adhesiveness can not pelletize greatly very much；It can not alleviate the amount by increasing mannitol.The study found that this is because roselle is soaked
The hygroscopicity of cream powder is excessive, even increasing a small amount of dosage, will lead to particle can not form very well.
By above embodiments, preparation process through the invention is illustrated, stable and controllable for quality, taste flavor can be obtained
Superior, sour-sweet middle band nature fragrance, product colour is beautiful, and convenient granule and pressed candy is administered orally；It can be largely
Retain its efficacy active component, and favorable solubility, absorbs fast and complete, human bioavailability height, smaller dosage
Reach efficacy effect, there is tabletting after milling, Ultramicro-powder (fecula) or milling the incomparable advantage of application methods such as to swallow.
Innovative combination has been carried out to leaf of Moringa, roselle, acai berry extract in formula of the invention, has not masked Moringa only effectively
The heavier bitter taste of leaf, and product colour is made to be adjusted to more audiences'perception and the rose liked from the yellowish-brown of moringa oleifera leaf extractive
Rare red, color is beautiful.Meanwhile being paid by a large amount of creativeness, successfully solve mentioning for roselle, leaf of Moringa and the Brazilian certain kind of berries
Take the apparent hygroscopicity of object to the numerous technological challenges of the brings such as granulation, tabletting.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (10)
1. a kind of Moringa composition, it is characterised in that:
Comprising moringa oleifera leaf extractive, roselle extract, acai berry extract,
The moringa oleifera leaf extractive, roselle extract, acai berry extract (4~8) in mass ratio: (1~2): (1~4)
Proportion,
The moringa oleifera leaf extractive, roselle extract, acai berry extract extract obtain by the following method: drying is peppery
The wooden leaf, Roselle calyx or Brazilian certain kind of berries fruit powder press solid-liquid ratio 1kg ︰ (5~25) L extracting in water, in 50 DEG C~100 DEG C heating extractions
1~3 time, 0.3~2h is extracted every time.
2. a kind of preparation method of Moringa composite particles agent, which comprises the steps of:
(1) it extracts
Take dry leaf of Moringa, Roselle calyx by solid-liquid ratio 1kg ︰ (6~25) L extracting in water, in 50 DEG C~100 DEG C heating extractions
1~3 time, 0.5~2h is extracted every time, obtains leaf of Moringa, roselle extract；Leaf of Moringa can also be prepared respectively by above-mentioned steps to mention
Take liquid or roselle extract；
Take Brazilian certain kind of berries fruit powder by solid-liquid ratio 1kg ︰ (5~25) L extracting in water, in 50 DEG C~100 DEG C heating extractions, extract 0.3~
2h obtains Brazilian certain kind of berries extracting solution；
(2) Moringa leaf extract, roselle extract, Brazilian certain kind of berries extracting solution is obtained to step (1) to be purified, be concentrated, dry,
Obtain leaf of Moringa extract powder, roselle extract powder, Brazilian certain kind of berries extract powder；
(3) the Moringa composite particles agent is prepared by following either method:
1. the leaf of Moringa extract powder that step (2) is obtained, roselle extract powder, Brazilian certain kind of berries extract powder and auxiliary materials and mixing, use are wet
Method, which is pelletized, is made the agent of Moringa composite particles；
2. by step (1) obtain Moringa leaf extract, roselle extract, Brazilian certain kind of berries extracting solution are purified, are concentrated, be added
Moringa composite particles agent is made using spray-drying process in auxiliary material.
3. the preparation method of Moringa composite particles agent according to claim 2, it is characterised in that:
Leaf of Moringa extract powder described in step (3), roselle extract powder, Brazilian certain kind of berries extract powder be in mass ratio (4~8): (1~
2): (1~4) proportion；
Auxiliary material described in step (3) be Icing Sugar, stevioside, mannitol, lactose, beta-cyclodextrin and soluble starch at least
Two kinds；
Leaf of Moringa extract powder described in step (3), roselle extract powder, the gross mass of Brazilian certain kind of berries extract powder and auxiliary material press quality
Than 1:(1~2.2) proportion.
4. the preparation method of Moringa composite particles agent according to claim 2, it is characterised in that:
Leaf of Moringa described in step (1) or the solid-liquid ratio of roselle are 1kg ︰ (10~25) L；
The solid-liquid ratio of the Brazilian certain kind of berries described in step (1) is 1kg ︰ (10~25) L；
The Extracting temperature of leaf of Moringa described in step (1), roselle or the Brazilian certain kind of berries is 50 DEG C~80 DEG C；
The concrete operations of purifying described in step (2) be it is following any one:
1. filtering Moringa leaf extract, roselle extract, Brazilian certain kind of berries extracting solution take supernatant in 2~4 DEG C of 36~60h of standing
Liquid；
2. it will be centrifuged 10~30min with Moringa leaf extract, roselle extract, Brazil 8000~16000rpm of certain kind of berries extracting solution,
Supernatant is taken,
Up to the Moringa leaf extract after purification, roselle extract, Brazilian certain kind of berries extracting solution；
The step of wet granulation described in step (3) specifically: by leaf of Moringa extract powder, roselle extract powder, Brazilian certain kind of berries leaching
Cream powder and auxiliary materials and mixing are added solvent and softwood, granulation, drying are made；
Auxiliary material described in step (3) is Icing Sugar, mannitol, stevioside, soluble starch.
5. the preparation method of Moringa composite particles agent according to claim 4, it is characterised in that:
Moringa leaf extract after purification, roselle extract, Brazilian certain kind of berries extracting solution density be 1.1~1.12；
The Icing Sugar, mannitol, stevioside, soluble starch (0.5~2) in mass ratio: (3.5~10): (0.15~
0.5): (1~2) is matched；
The solvent is the ethanol solution that concentration is percent by volume 65~80%；
The dosage of the solvent is by solvent and total extract powder amount=(1~2.5) L:(1~4.5) Kg matched；
Leaf of Moringa described in step (1) or the solid-liquid ratio of roselle are 1kg ︰ (15~25) L；
The solid-liquid ratio of the Brazilian certain kind of berries described in step (1) is 1kg ︰ (20~25) L；
The Extracting temperature of leaf of Moringa described in step (1), roselle or the Brazilian certain kind of berries is 60 DEG C~70 DEG C.
6. the preparation method of Moringa composite particles agent according to claim 4, it is characterised in that:
The solvent is that concentration is the ethanol solution that percent by volume is 65%~75%；
The dosage of the solvent is by solvent and total extract powder amount=(1~1.5) L:(3~4.5) Kg matched；
The time of the extraction of leaf of Moringa or roselle described in step (1) is 1~1.5h；
The extraction time of the Brazilian certain kind of berries described in step (1) is 1~2h；
Drying described in step (2) is to be dried under reduced pressure.
7. the preparation method of Moringa composite particles agent according to claim 2, it is characterised in that:
The concrete operations of concentration described in step (2) are as follows:
In the state that vacuum degree is -0.03~0.08MPa, temperature is 70 DEG C~92 DEG C, be concentrated under reduced pressure into relative density be
For 1.3~1.35 to get the extract after concentration at 20 DEG C；
Drying described in step (2) is following any operation:
1. by the extract after concentration -10 DEG C~-80 DEG C pre-freezes for 24 hours, then vacuumize freeze-drying to moisture≤5.0%；
2. being dried under reduced pressure at 55 DEG C~70 DEG C of temperature to moisture≤5.0%.
8. a kind of compound pressed candy of Moringa, it is characterised in that:
Include Moringa composition described in claim 1 and auxiliary material.
9. the preparation method of the compound pressed candy of Moringa according to any one of claims 8, it is characterised in that:
It is made by Moringa composition described in claim 1 with tabletting after auxiliary materials and mixing.
10. Moringa composition described in claim 1 is in preparation prevention or the food of adjuvant treatment hyperlipidemia and atherosclerosis
Application in product or health food.
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| CN109362935A (en) * | 2018-10-09 | 2019-02-22 | 河南九九生物科技有限公司 | A kind of pressed candy and preparation method thereof containing leaf of Moringa and spirulina |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104256814A (en) * | 2014-09-12 | 2015-01-07 | 南华新世纪生物工程有限公司 | Preparation and production method of moringa oleifera health drink |
| CN104435257A (en) * | 2014-12-12 | 2015-03-25 | 云南云药医药研究有限公司 | Composition conducive to lowering of cholesterol, and preparation method, preparation and application of composition |
| CN104547045A (en) * | 2014-12-25 | 2015-04-29 | 福州嘉佑化学科技有限公司 | Compound moringa oleifera instant granules and preparation method thereof |
| KR101694758B1 (en) * | 2016-08-23 | 2017-01-11 | 김대현 | Extraction method of moringa oleifera leaf |
| CN107233366A (en) * | 2017-05-17 | 2017-10-10 | 华南农业大学 | A kind of leaf of Moringa granule and preparation method and application |
-
2018
- 2018-08-28 CN CN201810991084.8A patent/CN109123672A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104256814A (en) * | 2014-09-12 | 2015-01-07 | 南华新世纪生物工程有限公司 | Preparation and production method of moringa oleifera health drink |
| CN104435257A (en) * | 2014-12-12 | 2015-03-25 | 云南云药医药研究有限公司 | Composition conducive to lowering of cholesterol, and preparation method, preparation and application of composition |
| CN104547045A (en) * | 2014-12-25 | 2015-04-29 | 福州嘉佑化学科技有限公司 | Compound moringa oleifera instant granules and preparation method thereof |
| KR101694758B1 (en) * | 2016-08-23 | 2017-01-11 | 김대현 | Extraction method of moringa oleifera leaf |
| CN107233366A (en) * | 2017-05-17 | 2017-10-10 | 华南农业大学 | A kind of leaf of Moringa granule and preparation method and application |
Non-Patent Citations (2)
| Title |
|---|
| 深圳市金版文化发展有限公司: "《蔬菜养生大全》", 28 February 2007 * |
| 缪剑华等: "《南药与大南药》", 31 August 2014 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109362935A (en) * | 2018-10-09 | 2019-02-22 | 河南九九生物科技有限公司 | A kind of pressed candy and preparation method thereof containing leaf of Moringa and spirulina |
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