CN109481670A - A kind of composition that can be relieved insomnia and improve sleep quality - Google Patents
A kind of composition that can be relieved insomnia and improve sleep quality Download PDFInfo
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- CN109481670A CN109481670A CN201811526572.8A CN201811526572A CN109481670A CN 109481670 A CN109481670 A CN 109481670A CN 201811526572 A CN201811526572 A CN 201811526572A CN 109481670 A CN109481670 A CN 109481670A
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- 230000003860 sleep quality Effects 0.000 title claims abstract description 38
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 title claims abstract description 33
- 206010022437 insomnia Diseases 0.000 title claims abstract description 32
- 239000000284 extract Substances 0.000 claims abstract description 120
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- 238000000034 method Methods 0.000 claims description 28
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Classifications
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- Proteomics, Peptides & Aminoacids (AREA)
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Abstract
The invention discloses a kind of compositions that can be relieved insomnia and improve sleep quality, active principle comprising following parts by weight: 20-150 parts of freeze-dried royal jelly powder, 10-120 parts of Herba Hyperici perforati extract, 20-80 parts of red yeast rice, 60-120 parts of albumin polypeptide, 30-70 parts of rich magnesium yeast, seed extract 40-80 parts of Ghana, 60-100 parts of Wild jujube seeds extract, 80-140 parts of cherry fruit extract.The plant extracts and raw-food material composition components of the invention is simple, without any side effects to human body, has the function of adjusting circadian clock body clock, mitigates depression, improves sleep quality, has highly important actual promotional value.
Description
Technical field
The invention belongs to drugs and field of health care products, and in particular to a kind of combination that can be relieved insomnia and improve sleep quality
Object.
Background technique
It is led with the improvement of people ' s living standards with the accelerating rhythm of life, dietary structure and the unreasonable of living habit
The sleeping problems of cause are got worse.
" Chinese netizen's insomnia map in 2017 " finding shows that nearly 80% participation investigator once has insomnia to undergo,
The area most concentrated of insomniac is a line city such as Shanghai, Guangzhou and Beijing in insomnia map, this and the huge life in above-mentioned city
Operating pressure living is inseparable.
According to the Capital University of Medical Sciences to the diagnostic criteria of insomnia, appearance is one of 4 following, while hindering with daytime function
Hinder, can be diagnosed as having a sleepless night, four conditions are respectively: time for falling asleep is more than 30 minutes, and number of awakening whole night is more than 2 times, early awakening,
Sleep quality declines and total sleep time is less than 6 hours.It investigates while finding, insomnia can make diabetes, hypertension or obesity
Etc. risks increase, even result in the psychic problems such as depression.
Therefore, it for sleep disturbance crowd there is an urgent need to find a kind of sleep Adjusted Option of efficient and healthful, is given birth to adjusting
Object clock mitigates depression while improving sleep quality.Existing sleep regulation class product main composition takes off black for synthesis class
Element or other nerves stabilize ingredient, with the above-mentioned hormone product for representative there are certain dependence and deactivate after repeatedly
Property.
Therefore, the current health food be badly in need of exploitation and develop a kind of food source that suitable insomnia crowd takes, alleviates
Their insomnia, while ensureing their sleep quality, and then improve their quality of life.
Summary of the invention
The purpose of the present invention is overcome the deficiencies of the prior art and provide a kind of group that can be relieved insomnia and improve sleep quality
Close object.
The present invention adopts the following technical scheme:
A kind of composition that can be relieved insomnia and improve sleep quality, the active principle comprising following parts by weight:
20-150 parts of freeze-dried royal jelly powder, 10-120 parts of Herba Hyperici perforati extract, 20-80 parts of red yeast rice, albumin polypeptide 60-
120 parts, 30-70 parts of rich magnesium yeast, seed extract 40-80 parts of Ghana, 60-100 parts of Wild jujube seeds extract, cherry fruit extract
80-140 parts.
Preferably, the composition provided by the present invention that can be relieved insomnia and improve sleep quality, includes following parts by weight
Active principle:
80-150 parts of freeze-dried royal jelly powder, 70-120 parts of Herba Hyperici perforati extract, 70-80 parts of red yeast rice, albumin polypeptide 70-
80 parts, 40-70 parts of rich magnesium yeast, seed extract 50-80 parts of Ghana, 70-100 parts of Wild jujube seeds extract, cherry fruit extract
80-120 parts.
It is further preferred that in the composition provided by the present invention that can be relieved insomnia and improve sleep quality, it is described
Freeze-dried royal jelly powder is prepared by the following method:
The bee milk filtering and impurity removing of fresh acquisition is placed in the vacuum freeze drier that temperature is -42 DEG C, it is fast quick-frozen
The vacuum degree control of vacuum freeze drier is then 10 ± 0.2mmHg, the material temperature of royal jelly is made to be maintained at -25~-23 by knot
DEG C, the temperature of condenser is controlled at -52~-48 DEG C, forms biggish steam pressure difference to promote vapor to be discharged, while to freezing
Hothouse heating promotes the water sublimed of royal jelly, the moisture content of royal jelly is reduced to 1-3wt%, finally by roral jelly powder
It sieves with 100 mesh sieve after broken to get freeze-dried royal jelly powder.
It is further preferred that in the composition provided by the present invention that can be relieved insomnia and improve sleep quality, it is described
In Herba Hyperici perforati extract, the content of hyperforine is 2.6-3.4wt%.
Specifically, the Herba Hyperici perforati extract is prepared by the following method:
30 meshes, as St. john's wort powder will be crossed after St. john's wort vanes pulverizer smashing and grinding, to St. john's wort
The ethanol solution that the volume fraction of 22-28 times of weight is 65% is added in powder, extracts 2 times, extracts 25-40min every time, merges
Extracting solution, recycles ethyl alcohol, and vacuum concentration is spray-dried to get Herba Hyperici perforati extract.
It is further preferred that in the composition provided by the present invention that can be relieved insomnia and improve sleep quality, it is described
Ghana's seed extract is prepared by the following method:
The seed of African Ghana is crossed into 30 meshes, as Ghana's powder of seeds, Xiang Jiana seed powder after pulverizer is smashed and ground
The ethanol solution that the volume fraction of 18-25 times of weight is 60% is added in end, extracts 2 times, each 25-35min, merges and extracts
Liquid, recycles ethyl alcohol, and vacuum concentration is spray-dried to get Ghana's seed extract.
It is further preferred that in the composition provided by the present invention that can be relieved insomnia and improve sleep quality, it is described
Wild jujube seeds extract is prepared by the following method:
The dry seed of wild jujube is crossed into 30 meshes, as Spine Date Seed after pulverizer is smashed and ground, to spiny jujuba seed powder
The ethanol solution that the volume fraction of 18-24 times of weight is 60% is added in end, extracts 2 times, each 25-35min, merges and extracts
Liquid, recycles ethyl alcohol, and vacuum concentration is spray-dried to get Wild jujube seeds extract.
It is further preferred that in the composition provided by the present invention that can be relieved insomnia and improve sleep quality, it is described
In cherry fruit extract, melatonin content is more than or equal to 12.3ng/g.
Specifically, the cherry fruit extract is prepared by the following method:
Cherry fruit is smashed it through into filter, as cherry fruit liquid, the body of 8-12 times of weight is added into cherry fruit liquid
Fraction is 50% ethanol solution, is extracted 3 times, each 25-35min, combined extract, and ethyl alcohol is recycled, and vacuum concentration is spraying dry
It is dry to get cherry fruit extract.
It is further preferred that in the composition provided by the present invention that can be relieved insomnia and improve sleep quality, it is described
Red yeast rice is to be obtained by red kojic rice powder by distillation.
Still further preferably, in the composition provided by the present invention that can be relieved insomnia and improve sleep quality, institute
Stating red yeast rice is to be prepared by the following method: being that 70% ethyl alcohol carries out hot submersion by red kojic rice powder and volume fraction, takes maceration extract
It is evaporated under reduced pressure, gained distilled and concentrated solution is filtered, and finally filtrate is spray-dried to get red yeast rice.
It is further preferred that in the composition provided by the present invention that can be relieved insomnia and improve sleep quality, it is described
Albumin polypeptide is the active constituent extracted from ovalbumin.
Still further preferably, in the composition provided by the present invention that can be relieved insomnia and improve sleep quality, institute
Stating albumin polypeptide is to be prepared by the following method: by warm plain white through filter sterilization, then passing sequentially through complex enzyme gradient
Digestion and multi-stage separation after purification, are spray-dried to get albumin polypeptide.
It is further preferred that in the composition provided by the present invention that can be relieved insomnia and improve sleep quality, it is described
Rich magnesium yeast is to win peptide carrier technique by albumen, decomposes the surface protein on yeast cells and cell wall using ferment method,
And after eliminating anaphylactogen, the natural magnesium fortified yeast of the food form produced.
Still further preferably, in the composition provided by the present invention that can be relieved insomnia and improve sleep quality, also
Including 180-220 parts of D-sorbite, 180-220 parts of white granulated sugar, 0.3-0.8 parts of steviol glycoside, 0.4-0.6 parts of magnesium stearate.With
Upper raw material is as auxiliary material.
As optimal case, the composition provided by the present invention that can be relieved insomnia and improve sleep quality, comprising following
The active principle of parts by weight:
130-150 parts of freeze-dried royal jelly powder, 100-120 parts of Herba Hyperici perforati extract, 70-80 parts of red yeast rice, albumin polypeptide
70-80 parts, 40-70 parts of rich magnesium yeast, seed extract 50-80 parts of Ghana, 80-100 parts of Wild jujube seeds extract, cherry fruit extracts
80-112 parts of object.
Each raw material in the application is powdery, during use, is directly mixed each raw material.
Another object of the present invention is the food or health-care preparation that protection composition described herein is prepared into, example
It such as can be prepared into pulvis, capsule, gelatin candy, pressed candy form.It, can be as needed during preparing above-mentioned preparation
Customary adjuvant needed for addition.
The composition that can be relieved insomnia and improve sleep quality of the invention can increase in production according to corresponding ratio
Or reduce, as large-scale production can by kilogram or as unit of ton, small-scale production can also in grams, and weight can be with
It increases or reduces, but the raw material weight proportioning of soup processed constant rate between each composition.
The present invention can be relieved insomnia and the composition of improvement sleep quality has the advantages that
Plant extracts and raw-food material composition components according to the present invention are simple, to human body without any secondary work
With, have the function of adjust circadian clock body clock, mitigate depression, improve sleep quality.
Specific embodiment
With reference to embodiment, the embodiment of the present invention is furthur described in detail.
The following examples are intended to illustrate the invention, but is not limited to protection scope of the present invention, protection model of the invention
It encloses and is subject to claims.
Unless otherwise specified, experiment reagent used in the embodiment of the present invention and material etc. are commercially available, if not having
Body indicates, the conventional means that technological means used in the embodiment of the present invention is well known to the skilled person.
Raw materials used source in the embodiment of the present invention:
Freeze-dried royal jelly powder is made by oneself obtain by the following method:
The bee milk filtering and impurity removing of fresh acquisition is placed in the vacuum freeze drier that temperature is -42 DEG C, it is fast quick-frozen
The vacuum degree control of vacuum freeze drier is then 10mmHg, so that the material temperature of royal jelly is maintained at -24 DEG C, condenser by knot
Temperature control at -50 DEG C, form biggish steam pressure difference to promote vapor to be discharged, at the same give freeze drying chamber heating promote
The moisture content of royal jelly is reduced to 2wt%, sieved with 100 mesh sieve after finally crushing royal jelly, i.e., by the water sublimed of royal jelly
Obtain freeze-dried royal jelly powder.
Herba Hyperici perforati extract is made by oneself obtain by the following method:
30 meshes, as St. john's wort powder will be crossed after St. john's wort vanes pulverizer smashing and grinding, to St. john's wort
The ethanol solution that the volume fraction of 25 times of weight is 65% is added in powder, extracts 2 times, extracts 30min every time, merges and extracts
Liquid, recycles ethyl alcohol, and vacuum concentration is spray-dried to get Herba Hyperici perforati extract, wherein the content of hyperforine is
3.2wt%.
Red yeast rice is to be obtained by red kojic rice powder by distillation, and specifically self-control obtains by the following method: by red kojic rice powder and body
Fraction is that 70% ethyl alcohol carries out hot submersion, and maceration extract is taken to be evaporated under reduced pressure, and gained distilled and concentrated solution is filtered, and finally will
Filtrate is spray-dried to get red yeast rice.
Albumin polypeptide is the active constituent extracted from ovalbumin, and specifically self-control obtains by the following method: will warm up
Plain white is through filter sterilization, then passes sequentially through the digestion of complex enzyme gradient and multi-stage separation after purification, is spray-dried to get clear egg
White polypeptide.
Rich magnesium yeast is to win peptide carrier technique by albumen, decomposes the surface on yeast cells and cell wall using ferment method
Protein, and after eliminating anaphylactogen, the natural magnesium fortified yeast of the food form produced.
Ghana's seed extract is made by oneself obtain by the following method:
The seed of African Ghana is crossed into 30 meshes, as Ghana's powder of seeds, Xiang Jiana seed powder after pulverizer is smashed and ground
The ethanol solution that the volume fraction of 20 times of weight is 60% is added in end, extracts 2 times, each 30min, combined extract, recycling
Ethyl alcohol, vacuum concentration are spray-dried to get Ghana's seed extract.
Wild jujube seeds extract is made by oneself obtain by the following method:
The dry seed of wild jujube is crossed into 30 meshes, as Spine Date Seed after pulverizer is smashed and ground, to spiny jujuba seed powder
The ethanol solution that the volume fraction of 20 times of weight is 60% is added in end, extracts 2 times, each 30min, combined extract, recycling
Ethyl alcohol, vacuum concentration are spray-dried to get Wild jujube seeds extract.
Cherry fruit extract is made by oneself obtain by the following method:
Cherry fruit is smashed it through into filter, as cherry fruit liquid, the volume of 10 times of weight is added into cherry fruit liquid
Score is 50% ethanol solution, is extracted 3 times, each 30min, combined extract, and ethyl alcohol is recycled, and is concentrated in vacuo, spray drying, i.e.,
Obtain cherry fruit extract, wherein melatonin content 13.1ng/g.
D-sorbite, white granulated sugar, steviol glycoside and magnesium stearate auxiliary material are commercial product.
In preparation process of the present invention, unless otherwise specified, used means are this field conventional technology.
Embodiment 1
The present embodiments relate to the pressed candies being prepared by the composition of the application.
Each component in composition are as follows:
138 parts of freeze-dried royal jelly powder, 105 parts of Herba Hyperici perforati extract, 72 parts of red yeast rice, 76 parts of albumin polypeptide, rich magnesium ferment
It is 50 parts female, it is 75 parts of Ghana's seed extract, 96 parts of Wild jujube seeds extract, 108 parts of cherry fruit extract, 200 parts of D-sorbite, white
200 parts of granulated sugar, 0.5 part of steviol glycoside, 0.5 part of magnesium stearate.
The preparation method comprises the following steps:
1) freeze-dried royal jelly powder, Herba Hyperici perforati extract, red yeast rice, albumin polypeptide, rich magnesium yeast, Ghana's seed are extracted
40 meshes are crossed after object, Wild jujube seeds extract, cherry fruit extract, white granulated sugar, D-sorbite, steviol glycoside mixing, it will be described
Mixture investment stirrer for mixing is uniform, obtains mixture；
2) 20 parts of purified waters are added in the mixture, puts into oscillating granulator and is granulated, obtain wet granular, grain
14 mesh are spent, is then placed in dry to pellet moisture in 55 DEG C of drying box by the wet granular and is down to the 3% of gross weight, then will dry
Particle afterwards carries out whole grain, and the granularity of whole grain is 14 mesh；
3) magnesium stearate that 0.5 part is added in particle again after the drying, is uniformly mixed, and is sent into tabletting in tablet press machine, pressure
Sheet weight is 500mg, finally sterilizes the tablet after tabletting, and finished product is made in packaging.
Embodiment 2
The present embodiments relate to the sleep regulation capsules being prepared by the composition of the application.
Each component in composition are as follows:
136 parts of freeze-dried royal jelly powder, 100 parts of Herba Hyperici perforati extract, 72 parts of red yeast rice, 70 parts of albumin polypeptide, rich magnesium ferment
It is 70 parts female, 68 parts of Ghana's seed extract, 100 parts of Wild jujube seeds extract, 105 parts of cherry fruit extract, 200 parts of D-sorbite,
200 parts of white granulated sugar, 0.5 part of steviol glycoside, 0.5 part of magnesium stearate.
The preparation method comprises the following steps:
By freeze-dried royal jelly powder, Herba Hyperici perforati extract, red yeast rice, albumin polypeptide, rich magnesium yeast, Ghana's seed extract,
Wild jujube seeds extract, cherry fruit extract, white granulated sugar, steviol glycoside and magnesium stearate carry out uniformly mixed, 40 meshes excessively, will
500mg be packed into gelatine capsule be made finished product to get.
Embodiment 3
The present embodiments relate to the sleep regulation compound powders being prepared by the composition of the application.
Each component in composition are as follows:
150 parts of freeze-dried royal jelly powder, 80 parts of Herba Hyperici perforati extract, 60 parts of red yeast rice, 70 parts of albumin polypeptide, rich magnesium yeast
60 parts, 40 parts of Ghana's seed extract, 70 parts of Wild jujube seeds extract, 120 parts of cherry fruit extract, 200 parts of D-sorbite, white sand
200 parts, 0.5 part of steviol glycoside, 0.5 part of magnesium stearate of sugar.
The preparation method comprises the following steps:
By freeze-dried royal jelly powder, Herba Hyperici perforati extract, red yeast rice, albumin polypeptide, rich magnesium yeast, Ghana's seed extract,
Wild jujube seeds extract, cherry fruit extract, white granulated sugar, steviol glycoside and magnesium stearate are granulated after mixing, cross 40 meshes,
Gained mixture is finished product, is packed into 500mg inner wrapping.
Embodiment 4
The present embodiments relate to the sleep regulation compound powders being prepared by the composition of the application.
Each component in composition are as follows:
150 parts of freeze-dried royal jelly powder, 120 parts of Herba Hyperici perforati extract, 80 parts of red yeast rice, 80 parts of albumin polypeptide, rich magnesium ferment
It is 30 parts female, 40 parts of Ghana's seed extract, 100 parts of Wild jujube seeds extract, 80 parts of cherry fruit extract, 200 parts of white granulated sugar, sorb
200 parts of sugar alcohol, 0.5 part of steviol glycoside, 0.5 part of magnesium stearate.
The preparation method comprises the following steps:
By freeze-dried royal jelly powder, Herba Hyperici perforati extract, red yeast rice, albumin polypeptide, rich magnesium yeast, Ghana's seed extract,
Wild jujube seeds extract, cherry fruit extract, white granulated sugar, D-sorbite, steviol glycoside and magnesium stearate are granulated after mixing,
40 meshes are crossed, gained mixture is finished product, is packed into 500mg inner wrapping.
Comparative example 1
The present embodiments relate to the sleep regulation capsules being prepared by the composition of the application.
Each component in composition are as follows:
140 parts of freeze-dried royal jelly powder, 110 parts of Herba Hyperici perforati extract, 75 parts of red yeast rice, 72 parts of albumin polypeptide, rich magnesium ferment
It is 30 parts female, 82 parts of Wild jujube seeds extract, 96 parts of cherry fruit extract, 200 parts of D-sorbite, 200 parts of white granulated sugar, steviol glycoside
0.5 part, 0.5 part of magnesium stearate, gelatine capsule shell.
The preparation method comprises the following steps:
By freeze-dried royal jelly powder, Herba Hyperici perforati extract, red yeast rice, albumin polypeptide, rich magnesium yeast, Ghana's seed extract,
Wild jujube seeds extract, cherry fruit extract, white granulated sugar, D-sorbite, steviol glycoside and magnesium stearate carry out uniformly mixed, mistake
40 meshes, by 500mg loading gelatine capsule be made finished product to get.
Experimental example
The effect of adjusting circadian clock body clock, relieving insomnia, improvement sleep quality is tested
Experiment purpose: the sleeping time of subject, fall asleep required time, Pittsburgh Sleep are studied after taking product of the present invention
The variation of performance figure, cortisol index, serotonin index.
Experimental subjects and mode
2.1 experimental subjects: 300 have insomnia, sleep disturbance, sleep quality poor are collected by Beijing Sport University
Life is screened, and subject does not take antidepression or stable class drug within 1 year, does not carry out mental disorder correlation
Treatment.By " Pittsburgh Sleep Quality Index " questionnaire, (the index total score range is 0-2l, and score is higher, indicates sleep quality
It is poorer), screening score is grouped the subject of not (sleep quality is very poor) in 16-21；Final 60 schoolgirls and 60 boy students meet
Condition, and voluntary participation this experiment, sign informed consent form before experiment.
2.2 test method
2.2.1 experiment test specifically include that subject's sleeping time, fall asleep required time, Pittsburgh Sleep Quality Index,
Cortisol index, serotonin index.
2.2.2 experimental group is as follows:
20 people of A group, sleeps take within first 30 minutes sleep regulation pressed candy 1 in embodiment 1 daily by men and women each 10, even
It is continuous to take 6 weeks.
20 people of B group, sleeps first 30 minutes daily and takes sleep regulation capsule 1 in embodiment 2 by men and women each 10, continuous to take
With 6 weeks.
20 people of C group, sleeps take within first 30 minutes the packet of sleep regulation compound powder 1 in embodiment 3 daily, even by men and women each 10
It is continuous to take 6 weeks.
20 people of D group, sleeps take within first 30 minutes the packet of sleep regulation compound powder 1 in embodiment 4 daily, even by men and women each 10
It is continuous to take 6 weeks.
20 people of E group, sleeps first 30 minutes daily and takes placebo and D-sorbite, white granulated sugar, stevioside by men and women each 10
Glycosides, magnesium stearate mixture are a (500mg/ parts), continuously take 6 weeks.
20 people of F group, sleeps first 30 minutes daily and takes sleep regulation capsule 1 in comparative example 1 by men and women each 10, continuous to take
With 6 weeks.
2.2.3 all subjects take previous evening sleep before and take 6 weeks latter evenings sleep before carry out Pittsburgh
Index test the time required to next morning counts subject's sleeping time, falls asleep, and acquires subject's blood examination skin
Matter alcohol index, serotonin index.
2.2.4 result counts
All data measureds use mean ± standard deviation (X ± SD) to indicate, are counted and are divided using SPSS22.0 software
Analysis.Indices variation uses independent samples t test between group, organizes interior indices variation and uses paired-sample t test.
2.2.5 experimental result
It is respectively that 6 weeks sleep regulations intervene forward and backward subject's sleep state and body index situation of change shown in table 1.
The result of analytical table 1 it can be concluded that, take the subject of A group and B group after taking product, Pittsburgh
Index, fall asleep required time, cortisol index have conspicuousness decline, and sleeping time and serotonin index have conspicuousness rising,
Illustrate that this product has achieved the effect that improving sleep quality especially increases sleeping time and reduce time for falling asleep；Take C group and D
The subject of group is after taking product, only Pittsburgh Sleep Quality Index and the more apparent decline of cortisol index；Take placebo E
Subject's items body index of group and comparative example F group is without significant change.
Comprehensive analysis above data result, which can be seen that, has taken the best part of functional component again than for freeze-dried royal jelly powder
138 parts, 105 parts of Herba Hyperici perforati extract, 72 parts of red yeast rice, 76 parts of albumin polypeptide, 50 parts of rich magnesium yeast, Ghana's seed extract 75
Part, 96 parts of Wild jujube seeds extract, 108 parts of cherry fruit extract of A group subject's sleep quality improves situation and is better than B, also bright
The aobvious subject better than C group and D group, while being also significantly better than the subject of placebo E group and comparative example F group.
Conclusion
In terms of whole experiment process, after subject quantitatively takes product of the invention for a long time, Pittsburgh Sleep Quality Index,
The time required to falling asleep, cortisol index there is conspicuousness decline to have and decline significantly, and sleeping time and serotonin index have
Conspicuousness rises.This shows to take the effect of this product can achieve relieving insomnia and improve sleep quality.In addition, being helped with tradition
Sleep assistant health product is compared, and this product raw material is mainly raw-food material or from food, so that it is guaranteed that the sleep regulation scheme
Health and sustainability.
Although above having used general explanation, specific embodiment and test, the present invention is made to retouch in detail
It states, but on the basis of the present invention, it can be made some modifications or improvements, this is apparent to those skilled in the art
's.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to claimed
Range.
Claims (10)
1. a kind of composition that can be relieved insomnia and improve sleep quality, which is characterized in that effective group comprising following parts by weight
Point:
20-150 parts of freeze-dried royal jelly powder, 10-120 parts of Herba Hyperici perforati extract, 20-80 parts of red yeast rice, albumin polypeptide 60-120
Part, 30-70 parts of rich magnesium yeast, seed extract 40-80 parts of Ghana, 60-100 parts of Wild jujube seeds extract, cherry fruit extract 80-
140 parts.
2. composition according to claim 1, which is characterized in that the active principle comprising following parts by weight:
80-150 parts of freeze-dried royal jelly powder, 70-120 parts of Herba Hyperici perforati extract, 70-80 parts of red yeast rice, albumin polypeptide 70-80
Part, 40-70 parts of rich magnesium yeast, seed extract 50-80 parts of Ghana, 70-100 parts of Wild jujube seeds extract, cherry fruit extract 80-
120 parts.
3. composition according to claim 1 or 2, which is characterized in that the freeze-dried royal jelly powder is prepared by the following method
It obtains:
The bee milk filtering and impurity removing of fresh acquisition is placed in the vacuum freeze drier that temperature is -42 DEG C, quick freezing, with
It is afterwards 9.8-10.2mmHg by the vacuum degree control of vacuum freeze drier, the material temperature of royal jelly is made to be maintained at -25~-23 DEG C,
The temperature of condenser is controlled at -52~-48 DEG C, forms biggish steam pressure difference to promote vapor to be discharged, while dry to freezing
Dry room heating promotes the water sublimed of royal jelly, and the moisture content of royal jelly is reduced to 1-3wt%, finally crushes royal jelly
After sieve with 100 mesh sieve to get freeze-dried royal jelly powder.
4. composition according to claim 1 or 2, which is characterized in that
In the Herba Hyperici perforati extract, the content of hyperforine is 2.6-3.4wt%,
Preferably, the Herba Hyperici perforati extract is prepared by the following method:
30 meshes, as St. john's wort powder will be crossed after St. john's wort vanes pulverizer smashing and grinding, to St. john's wort powder
The ethanol solution that the middle volume fraction that 22-28 times of weight is added is 65%, is extracted 2 times, extracts 25-40min every time, is merged and is extracted
Liquid, recycles ethyl alcohol, and vacuum concentration is spray-dried to get Herba Hyperici perforati extract；
And/or Ghana's seed extract is prepared by the following method:
The seed of African Ghana is crossed into 30 meshes after pulverizer is smashed and ground, as Ghana's powder of seeds, in Xiang Jiana powder of seeds
The ethanol solution that the volume fraction of 18-25 times of weight is 60% is added, extracts 2 times, each 25-35min, combined extract, returns
Ethyl alcohol is received, vacuum concentration is spray-dried to get Ghana's seed extract；
And/or the Wild jujube seeds extract is prepared by the following method:
The dry seed of wild jujube is crossed into 30 meshes, as Spine Date Seed after pulverizer is smashed and ground, into Spine Date Seed
The ethanol solution that the volume fraction of 18-24 times of weight is 60% is added, extracts 2 times, each 25-35min, combined extract, returns
Ethyl alcohol is received, vacuum concentration is spray-dried to get Wild jujube seeds extract；
And/or in the cherry fruit extract, melatonin content is more than or equal to 12.3ng/g,
Preferably, the cherry fruit extract is prepared by the following method:
Cherry fruit is smashed it through into filter, as cherry fruit liquid, the volume point of 8-12 times of weight is added into cherry fruit liquid
Number is 50% ethanol solution, is extracted 3 times, each 25-35min, combined extract, and ethyl alcohol is recycled, and is concentrated in vacuo, spray drying,
Up to cherry fruit extract.
5. composition according to claim 1 or 2, which is characterized in that the red yeast rice is to be obtained by red kojic rice powder by distillation
?；
Preferably, it is prepared by the following method: being that 70% ethyl alcohol carries out hot submersion by red kojic rice powder and volume fraction, take dipping
Liquid is evaporated under reduced pressure, and gained distilled and concentrated solution is filtered, and finally filtrate is spray-dried to get red yeast rice.
6. composition according to claim 1 or 2, which is characterized in that the albumin polypeptide is mentioned from ovalbumin
The active constituent taken；
Preferably, it is prepared by the following method: by warm plain white through filter sterilization, then passing sequentially through complex enzyme gradient digestion
After purification with multi-stage separation, spray drying is to get albumin polypeptide.
7. composition according to claim 1 or 2, which is characterized in that the rich magnesium yeast is to win peptide carrier by albumen
Technology decomposes the surface protein on yeast cells and cell wall using ferment method, and after eliminating anaphylactogen, the food produced
The natural magnesium fortified yeast of form.
8. composition according to claim 1-7, which is characterized in that it further include 180-220 parts of D-sorbite, it is white
180-220 parts of granulated sugar, 0.3-0.8 parts of steviol glycoside, 0.4-0.6 parts of magnesium stearate.
9. composition according to claim 1-8, which is characterized in that the active principle comprising following parts by weight:
130-150 parts of freeze-dried royal jelly powder, 100-120 parts of Herba Hyperici perforati extract, 70-80 parts of red yeast rice, albumin polypeptide 70-80
Part, 40-70 parts of rich magnesium yeast, seed extract 50-80 parts of Ghana, 80-100 parts of Wild jujube seeds extract, cherry fruit extract 80-
112 parts.
10. food or health-care preparation that the described in any item compositions of claim 1-9 are prepared into.
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| CN112869162A (en) * | 2021-02-08 | 2021-06-01 | 宁波御坊堂生物科技有限公司 | Composition with functions of resisting fatigue and improving sleep and preparation method thereof |
| CN113367341A (en) * | 2021-06-29 | 2021-09-10 | 华纳盛世(武汉)生物科技有限公司 | Composition for soothing nerves and improving sleep and preparation method thereof |
| CN116686990A (en) * | 2023-08-09 | 2023-09-05 | 内蒙古蒙牛乳业（集团）股份有限公司 | Functional composition, functional beverage and preparation method thereof |
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| CN116686990A (en) * | 2023-08-09 | 2023-09-05 | 内蒙古蒙牛乳业（集团）股份有限公司 | Functional composition, functional beverage and preparation method thereof |
| CN116686990B (en) * | 2023-08-09 | 2023-10-31 | 内蒙古蒙牛乳业（集团）股份有限公司 | Functional composition, functional beverage and preparation method thereof |
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