CN113367341A - Composition for soothing nerves and improving sleep and preparation method thereof - Google Patents
Composition for soothing nerves and improving sleep and preparation method thereof Download PDFInfo
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- CN113367341A CN113367341A CN202110732365.3A CN202110732365A CN113367341A CN 113367341 A CN113367341 A CN 113367341A CN 202110732365 A CN202110732365 A CN 202110732365A CN 113367341 A CN113367341 A CN 113367341A
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- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Botany (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to the field of medicinal and edible foods, and discloses a composition for soothing nerves and improving sleep and a preparation method thereof, wherein the composition comprises passion fruit extract, spina date seed concentrated powder, lily extract, gardnerella seed extract, chamomile extract and spearmint extract, and the preparation method comprises the following steps: weighing passion fruit extract, spina date seed concentrated powder, lily extract, Griffonia simplicifolia seed extract, chamomile extract and spearmint extract according to the formula amount, uniformly mixing to obtain a mixture, adding deionized water, and uniformly stirring to obtain a mixed solution; refining the mixed solution by a colloid mill and a homogenizer in sequence, and spray drying the homogenized solution to obtain the composition. The composition has the effects of soothing nerves, stabilizing emotion, mildly resisting anxiety and treating sleep disorder, and raw materials of the composition are extracted from natural herbaceous plants, so that the composition has no harm to human bodies.
Description
Technical Field
The invention relates to the field of medicinal and edible foods, in particular to a composition for soothing nerves and improving sleep and a preparation method thereof.
Background
The clinical manifestations of sleep disorders are most common with insomnia. Almost everyone experiences insomnia, generally speaking, the insomnia is seldom life-threatening, but the treatment is difficult, so that the patient is anxious and uneasy, and the daily life, work and physical and psychological health of people are seriously affected. Sleep disorder is one of the complicated series of diseases in neurology, and has the disadvantages of complicated and extensive classification, various clinical manifestations and close relation with etiology and pathogenesis. The sleep disorder has a plurality of etiologies, and physiological-psychological factors, genetic genes, body qualities, environmental conditions, social interpersonal relationship, mental stimulation, physical diseases, mental diseases, adverse drug reactions and the like can cause the sleep disorder. These causes can lead to abnormal sleep central parts and functions in the brain, or nerve biochemical changes caused by the abnormal sleep central parts and functions, and promote the disorder of sleep structure and process.
At present, sedative hypnotic drugs are commonly used as chemical drugs for improving sleep, and the sedative hypnotic drugs mainly comprise barbiturates such as phenobarbital, amobarbital and the like, benzodiazepines such as diazepam, estazolam and the like, and non-benzodiazepines such as zaleplon, zolpidem and the like. The action mechanism is mostly GABA receptor agonist, the side effect is large, the adverse reactions such as insomnia rebound, addiction, tolerance and the like are common, and the damage to the human body is large.
Disclosure of Invention
The first object of the present invention is to provide a composition for soothing the nerves and improving sleep, which has the effects of soothing the nerves, stabilizing the mood, mildly resisting anxiety, treating sleep disorder, and is harmless to the human body.
In order to achieve the above purpose, the basic scheme of the invention is as follows: the composition for soothing the nerves and improving the sleep comprises active components, wherein the active components comprise the following component substances in parts by weight:
furthermore, the coating also comprises auxiliary materials, wherein the auxiliary materials are hydroxypropyl methyl cellulose, magnesium stearate and microcrystalline cellulose.
Furthermore, the hydroxypropyl methyl cellulose is 1.5-2.5 parts by weight, the magnesium stearate is 0.2-1.0 part by weight, and the microcrystalline cellulose is 0.5-2.0 parts by weight.
Further, the passion fruit extract is prepared by the following method:
crushing and grinding passion fruit by a crusher, sieving by a 30-mesh sieve, adding an extraction solvent, and soaking for 1-2 h; adding the soaked passion fruit and a solvent into an ultrasonic oscillator for ultrasonic wall breaking, soaking the passion fruit subjected to ultrasonic wall breaking for 30-40min in warm water, centrifuging and filtering the passion fruit subjected to the warm water soaking treatment to obtain a supernatant; concentrating the obtained supernatant, and treating the filtrate to obtain the passion fruit extract.
Further, the griffonia simplicifolia seed extract is prepared by the following method:
pulverizing and grinding seeds of African gardner by a pulverizer, sieving with a 50-mesh sieve to obtain gardner seed powder, adding 15-20 times by weight of 60% ethanol solution by volume fraction into the gardner seed powder, extracting for 2-3 times, each time for 20-30min, mixing extractive solutions, recovering ethanol, vacuum concentrating, and spray drying to obtain the gardner seed extract.
Further, the chamomile extract is prepared by the following method:
crushing a chamomile raw material, adding deionized water with the weight of 2-5 times of that of the chamomile raw material, and mixing to obtain chamomile slurry; filtering, precipitating, centrifuging and concentrating the chamomile slurry to obtain the chamomile extract.
Further, the microcapsule also comprises a membrane component, wherein the membrane component comprises chitosan and sodium alginate, and the membrane component is coated outside the active component to form the microcapsule.
Compared with the prior art, the scheme has the beneficial effects that:
the passion fruit has neuroleptic effect, including mild sedative and anxiolytic effects; the wild jujube can nourish the five internal organs, invigorate the stomach and activate the spleen, calm and tranquilize the heart; spearmint extract is useful in the treatment of headache, migraine, nervous tension, fatigue and stress symptoms; the chamomile has the effect of helping sleep, relieving inflammation and pain symptoms of a patient and relieving insomnia caused by neuropathic skin pruritus; chamomile can relieve anxiety, tension, anger and fear, relax people, and make people feel patience and auspicious. Alleviate anxiety, calm the mind, and help insomnia. The Griffonia simplicifolia seed extract contains 5-hydroxytryptophan, and 5-hydroxytryptophan is a hormone secreted by brain, and can affect emotion, sleep and appetite, and 5-hydroxytryptophan is needed to maintain the body in a normal state when serotonin in the brain is unbalanced. Gardnia seed extract contains 5-hydroxytryptophan, and can be used for treating sleep disorder.
A second object of the present invention is to provide a method for preparing a composition for soothing nerves and improving sleep, which comprises the steps of:
1) mixing materials:
weighing passion fruit extract, spina date seed concentrated powder, lily extract, Griffonia simplicifolia seed extract, chamomile extract and spearmint extract according to the formula amount, uniformly mixing to obtain a mixture, adding deionized water, and uniformly stirring to obtain a mixed solution;
2) refining and homogenizing:
refining the mixed solution by a colloid mill;
homogenizing and refining the refined mixed solution by a homogenizer;
spray drying the homogenized solution to obtain an active component;
3) microencapsulation: mixing the active component with chitosan, sodium alginate, water and edible surfactant, and spray drying to obtain microcapsule for improving bone health.
Further, in the microencapsulation step, chitosan, sodium alginate and active ingredients are added and mixed evenly, and then the mixture is kept stand for 20-40min and then spray-dried.
Further, in the microencapsulation step, the particle size of the microcapsule obtained by spray drying is 40-60 meshes.
Detailed Description
The invention will be described in more detail by means of specific embodiments and with reference to the following description:
the raw material sources used in the embodiments and comparative examples of the present invention are:
the passion fruit extract is prepared by the following method:
crushing and grinding passion fruit by a crusher, sieving by a 30-mesh sieve, adding an extraction solvent, and soaking for 1 h; adding the soaked passion fruit and a solvent into an ultrasonic oscillator for ultrasonic wall breaking, soaking the passion fruit subjected to ultrasonic wall breaking for 30min in warm water, centrifuging and filtering the passion fruit subjected to the warm water soaking treatment to obtain a supernatant; concentrating the obtained supernatant, and treating the filtrate to obtain the passion fruit extract.
The griffonia simplicifolia seed extract is prepared by the following method:
pulverizing and grinding seeds of African Jiana by a pulverizer, sieving with a 50-mesh sieve to obtain Jiana seed powder, adding 15 times by weight of 60% ethanol solution, extracting for 3 times, each time for 30min, mixing extractive solutions, recovering ethanol, vacuum concentrating, and spray drying to obtain Jiana seed extract.
The wild jujube seed concentrated powder is prepared by the following method:
crushing spina date seeds, adding water according to the material-liquid ratio of 1:10, soaking at 90 ℃ for 2 hours, and filtering to obtain supernatant; adding water into the filtered filter residue according to the material-liquid ratio of 1:15, leaching and soaking for 1h at 100 ℃, and filtering to obtain a supernatant; mixing the supernatants, concentrating to obtain semen Ziziphi Spinosae extract 10%, adding starch 5%, drying, making into powder, and sieving with 60 mesh sieve to obtain semen Ziziphi Spinosae concentrated powder.
The lily extract is prepared by the following method:
extracting dried lily with 4 times of 60% methanol for 3 times, each time for 1 hr; mixing the extractive solutions, vacuum concentrating, and drying to obtain ethanol extract; adding 15 times of water into the alcohol extract to dissolve the alcohol extract into suspension, and extracting for 2 times by using 2 times of petroleum ether to obtain extract A; adding 1.5 times of ethyl acetate into the extract A to extract for 3 times to obtain an extract B; and concentrating the extract B, and drying to obtain the lily extract.
The chamomile extract is prepared by the following method:
crushing a chamomile raw material, adding deionized water with the weight being 5 times that of the chamomile raw material, and mixing to obtain chamomile slurry; filtering, precipitating, centrifuging and concentrating the chamomile slurry to obtain the chamomile extract.
The spearmint extract is prepared by the following method:
pulverizing dried herba Menthae Rotundifoliae whole plant, wrapping with filter paper, placing into Soxhlet extractor, soaking with 75% ethanol overnight, continuously reflux extracting for 6 hr, collecting ethanol extractive solution, drying under reduced pressure until black precipitate appears, extracting with petroleum ether for 3 times, and removing petroleum ether extraction layer; extracted again with ethyl acetate for 3 times, concentrated under reduced pressure and dried to give the spearmint extract of the present application.
The saffron extract is prepared by the following method:
grinding stigma croci to 60 mesh to obtain stigma croci powder; adding saffron crocus powder into 10 times of ethanol solution with volume fraction of 60% by weight, performing ultrasonic treatment, filtering, and removing filter residue to obtain filtrate A; placing the filtrate A in a water bath at 50 ℃, centrifuging after the water bath, and obtaining supernatant; adding the supernatant into 70% ethanol, further extracting in microwave extraction equipment, filtering, and removing the filter residue to obtain filtrate B; and (4) concentrating the filtrate B under reduced pressure, adjusting the pH value to 6.4, and drying in vacuum to obtain the saffron extract.
Example 1:
a composition for soothing nerves and improving sleep comprises the following component substances (g) in parts by weight:
the preparation method comprises the following steps:
1) mixing materials:
weighing passion fruit extract, spina date seed concentrated powder, lily extract, griffonia seed extract, chamomile extract, spearmint extract, saffron extract, hydroxypropyl methyl cellulose, magnesium stearate and microcrystalline cellulose according to the formula amount, uniformly mixing to obtain a mixture, adding water, and uniformly stirring to obtain a mixed solution, wherein the weight ratio of the mixture to the water is 1: 2;
2) refining and homogenizing:
refining the mixed solution by a colloid mill, wherein the clearance between a stator and a rotor of the colloid mill is 20 microns, and the time is 20 min;
homogenizing and refining the refined mixed solution by a homogenizer at the homogenizing pressure of 40 MPa;
spray drying the homogenized solution at an atomization pressure of 0.3MPa to obtain an active component;
3) microencapsulation: mixing the active component, chitosan, sodium alginate, water and edible surfactant at a ratio of 1:1: 2: 2, standing for 40min after uniformly mixing, and then carrying out spray drying to obtain the composition with the microcapsule particle size of 40 meshes for soothing the nerves and improving the sleep.
Example 2:
a composition for soothing nerves and improving sleep comprises the following component substances (g) in parts by weight:
the preparation method comprises the following steps:
1) mixing materials:
weighing passion fruit extract, spina date seed concentrated powder, lily extract, griffonia seed extract, chamomile extract, spearmint extract, saffron extract, hydroxypropyl methyl cellulose, magnesium stearate and microcrystalline cellulose according to the formula amount, uniformly mixing to obtain a mixture, adding water, and uniformly stirring to obtain a mixed solution, wherein the weight ratio of the mixture to the water is 1: 2;
2) refining and homogenizing:
refining the mixed solution by a colloid mill, wherein the clearance between a stator and a rotor of the colloid mill is 20 microns, and the time is 20 min;
homogenizing and refining the refined mixed solution by a homogenizer at the homogenizing pressure of 40 MPa;
spray drying the homogenized solution at an atomization pressure of 0.3MPa to obtain an active component;
3) microencapsulation: mixing the active component, chitosan, sodium alginate, water and edible surfactant at a ratio of 1:1: 2: 2, standing for 40min after uniformly mixing, and then carrying out spray drying to obtain the composition with the microcapsule particle size of 40 meshes for soothing the nerves and improving the sleep.
Example 3:
a composition for soothing nerves and improving sleep comprises the following component substances (g) in parts by weight:
the preparation method comprises the following steps:
1) mixing materials:
weighing passion fruit extract, spina date seed concentrated powder, lily extract, griffonia seed extract, chamomile extract, spearmint extract, saffron extract, hydroxypropyl methyl cellulose, magnesium stearate and microcrystalline cellulose according to the formula amount, uniformly mixing to obtain a mixture, adding water, and uniformly stirring to obtain a mixed solution, wherein the weight ratio of the mixture to the water is 1: 2;
2) refining and homogenizing:
refining the mixed solution by a colloid mill, wherein the clearance between a stator and a rotor of the colloid mill is 20 microns, and the time is 20 min;
homogenizing and refining the refined mixed solution by a homogenizer at the homogenizing pressure of 40 MPa;
spray drying the homogenized solution at an atomization pressure of 0.3MPa to obtain an active component;
3) microencapsulation: mixing the active component, chitosan, sodium alginate, water and edible surfactant at a ratio of 1:1: 2: 2, standing for 40min after uniformly mixing, and then carrying out spray drying to obtain the composition with the microcapsule particle size of 40 meshes for soothing the nerves and improving the sleep.
Example 4:
a composition for soothing nerves and improving sleep comprises the following component substances (g) in parts by weight:
the preparation method comprises the following steps:
1) mixing materials:
weighing passion fruit extract, spina date seed concentrated powder, lily extract, griffonia seed extract, chamomile extract, spearmint extract, saffron extract, hydroxypropyl methyl cellulose, magnesium stearate and microcrystalline cellulose according to the formula amount, uniformly mixing to obtain a mixture, adding water, and uniformly stirring to obtain a mixed solution, wherein the weight ratio of the mixture to the water is 1: 2;
2) refining and homogenizing:
refining the mixed solution by a colloid mill, wherein the clearance between a stator and a rotor of the colloid mill is 20 microns, and the time is 20 min;
homogenizing and refining the refined mixed solution by a homogenizer at the homogenizing pressure of 40 MPa;
spray drying the homogenized solution at an atomization pressure of 0.3MPa to obtain an active component;
3) microencapsulation: mixing the active component, chitosan, sodium alginate, water and edible surfactant at a ratio of 1:1: 2: 2, standing for 40min after uniformly mixing, and then carrying out spray drying to obtain the composition with the microcapsule particle size of 40 meshes for soothing the nerves and improving the sleep.
Example 5:
a composition for soothing nerves and improving sleep comprises the following component substances (g) in parts by weight:
the preparation method comprises the following steps:
1) mixing materials:
weighing passion fruit extract, spina date seed concentrated powder, lily extract, griffonia seed extract, chamomile extract, spearmint extract, saffron extract, hydroxypropyl methyl cellulose, magnesium stearate and microcrystalline cellulose according to the formula amount, uniformly mixing to obtain a mixture, adding water, and uniformly stirring to obtain a mixed solution, wherein the weight ratio of the mixture to the water is 1: 2;
2) refining and homogenizing:
refining the mixed solution by a colloid mill, wherein the clearance between a stator and a rotor of the colloid mill is 20 microns, and the time is 20 min;
homogenizing and refining the refined mixed solution by a homogenizer at the homogenizing pressure of 40 MPa;
spray drying the homogenized solution at an atomization pressure of 0.3MPa to obtain an active component;
3) microencapsulation: mixing the active component, chitosan, sodium alginate, water and edible surfactant at a ratio of 1:1: 2: 2, standing for 40min after uniformly mixing, and then carrying out spray drying to obtain the composition with the microcapsule particle size of 40 meshes for soothing the nerves and improving the sleep.
Comparative example 1:
a composition for soothing nerves and improving sleep comprises the following component substances (g) in parts by weight:
the preparation method comprises the following steps:
1) mixing materials:
weighing passion fruit extract, spina date seed concentrated powder, lily extract, chamomile extract, spearmint extract, saffron extract, hydroxypropyl methyl cellulose, magnesium stearate and microcrystalline cellulose according to the formula amount, uniformly mixing to obtain a mixture, adding water, and uniformly stirring to obtain a mixed solution, wherein the weight ratio of the mixture to the water is 1: 2;
2) refining and homogenizing:
refining the mixed solution by a colloid mill, wherein the clearance between a stator and a rotor of the colloid mill is 20 microns, and the time is 20 min;
homogenizing and refining the refined mixed solution by a homogenizer at the homogenizing pressure of 40 MPa;
spray drying the homogenized solution at an atomization pressure of 0.3MPa to obtain an active component;
3) microencapsulation: mixing the active component, chitosan, sodium alginate, water and edible surfactant at a ratio of 1:1: 2: 2, standing for 40min after even mixing, and spray drying to obtain the composition with the microcapsule particle size of 40 meshes.
Comparative example 2:
a composition for soothing nerves and improving sleep comprises the following component substances (g) in parts by weight:
the preparation method comprises the following steps:
1) mixing materials:
weighing passion fruit extract, spina date seed concentrated powder, lily extract, griffonia seed extract, spearmint extract, saffron extract, hydroxypropyl methyl cellulose, magnesium stearate and microcrystalline cellulose according to the formula amount, uniformly mixing to obtain a mixture, adding water, and uniformly stirring to obtain a mixed solution, wherein the weight ratio of the mixture to the water is 1: 2;
2) refining and homogenizing:
refining the mixed solution by a colloid mill, wherein the clearance between a stator and a rotor of the colloid mill is 20 microns, and the time is 20 min;
homogenizing and refining the refined mixed solution by a homogenizer at the homogenizing pressure of 40 MPa;
spray drying the homogenized solution at an atomization pressure of 0.3MPa to obtain an active component;
3) microencapsulation: mixing the active component, chitosan, sodium alginate, water and edible surfactant at a ratio of 1:1: 2: 2, standing for 40min after even mixing, and spray drying to obtain the composition with the microcapsule particle size of 40 meshes.
Comparative example 3:
a composition for soothing nerves and improving sleep comprises the following component substances (g) in parts by weight:
the preparation method comprises the following steps:
1) mixing materials:
weighing passion fruit extract, spina date seed concentrated powder, lily extract, griffonia seed extract, chamomile extract, saffron extract, hydroxypropyl methyl cellulose, magnesium stearate and microcrystalline cellulose according to the formula amount, uniformly mixing to obtain a mixture, adding water, and uniformly stirring to obtain a mixed solution, wherein the weight ratio of the mixture to the water is 1: 2;
2) refining and homogenizing:
refining the mixed solution by a colloid mill, wherein the clearance between a stator and a rotor of the colloid mill is 20 microns, and the time is 20 min;
homogenizing and refining the refined mixed solution by a homogenizer at the homogenizing pressure of 40 MPa;
spray drying the homogenized solution at an atomization pressure of 0.3MPa to obtain an active component;
3) microencapsulation: mixing the active component, chitosan, sodium alginate, water and edible surfactant at a ratio of 1:1: 2: 2, standing for 40min after even mixing, and spray drying to obtain the composition with the microcapsule particle size of 40 meshes.
Experimental example:
purpose of the experiment: the changes of the sleeping time, the time required for falling asleep and the 5-hydroxytryptamine index of the testee after taking the product of the invention are researched.
Experimental samples: the compositions obtained in examples 1 to 5 and comparative examples 1 to 3.
Subject and mode:
48 volunteers with insomnia symptom, sleep disorder and poor sleep quality are collected for screening, and the subjects do not take antidepressant or tranquilizer within 1 year, and do not perform treatment related to mental diseases. 3 males and 3 females were selected as 1 group, and 2 microcapsules of the compositions obtained in examples 1 to 5 and comparative examples 1 to 3 were administered to each group for 6 weeks.
All subjects were tested before taking a sleep night before taking the test and after taking the test before taking a sleep night after 6 weeks, the sleep time and the time required for falling asleep of the subjects were counted in the next morning, and blood samples of the subjects were collected to detect the 5-hydroxytryptamine index.
The test results are shown in Table 1
TABLE 1
As can be seen from the results in Table 1, the time required for a subject to fall asleep was significantly reduced and the sleep time and 5-hydroxytryptamine index were significantly increased in the compositions of examples 1 to 6 and comparative examples 1 to 3 after administration of the compositions of examples 1 to 6, as compared to before the test; the time required to fall asleep was also reduced in subjects taking the compositions of comparative examples 1-3, but the effect was not significant; the sleeping time and the 5-hydroxytryptamine index are also increased, but the effect is not obvious.
And (4) conclusion: the composition has the effects of relieving anxiety and tension, calming nerves and helping sleep.
The foregoing is merely an example of the present invention and common general knowledge of known specific structures and features of the embodiments is not described herein in any greater detail. It should be noted that, for those skilled in the art, without departing from the structure of the present invention, several changes and modifications can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicability of the patent. The scope of the claims of the present application shall be determined by the contents of the claims, and the description of the embodiments and the like in the specification shall be used to explain the contents of the claims.
Claims (10)
1. A composition for soothing nerves and improving sleep is characterized in that: the active component comprises the following components in parts by weight:
2. the composition for soothing the nerves and improving sleep as claimed in claim 1, wherein: the magnesium stearate health care product also comprises auxiliary materials, wherein the auxiliary materials are hydroxypropyl methyl cellulose, magnesium stearate and microcrystalline cellulose.
3. The composition for soothing the nerves and improving sleep as claimed in claim 2, wherein: the hydroxypropyl methyl cellulose is 1.5-2.5 parts by weight, the magnesium stearate is 0.2-1.0 part by weight, and the microcrystalline cellulose is 0.5-2.0 parts by weight.
4. The composition for soothing the nerves and improving sleep as claimed in claim 1, wherein: the passion fruit extract is prepared by the following method:
crushing and grinding passion fruit by a crusher, sieving by a 30-mesh sieve, adding an extraction solvent, and soaking for 1-2 h; adding the soaked passion fruit and a solvent into an ultrasonic oscillator for ultrasonic wall breaking, soaking the passion fruit subjected to ultrasonic wall breaking for 30-40min in warm water, centrifuging and filtering the passion fruit subjected to the warm water soaking treatment to obtain a supernatant; concentrating the obtained supernatant, and treating the filtrate to obtain the passion fruit extract.
5. The composition for soothing the nerves and improving sleep as claimed in claim 1, wherein: the griffonia simplicifolia seed extract is prepared by the following method:
pulverizing and grinding seeds of African gardner by a pulverizer, sieving with a 50-mesh sieve to obtain gardner seed powder, adding 15-20 times by weight of 60% ethanol solution by volume fraction into the gardner seed powder, extracting for 2-3 times, each time for 20-30min, mixing extractive solutions, recovering ethanol, vacuum concentrating, and spray drying to obtain the gardner seed extract.
6. The composition for soothing the nerves and improving sleep as claimed in claim 1, wherein: the chamomile extract is prepared by the following method:
crushing a chamomile raw material, adding deionized water with the weight of 2-5 times of that of the chamomile raw material, and mixing to obtain chamomile slurry; filtering, precipitating, centrifuging and concentrating the chamomile slurry to obtain the chamomile extract.
7. The composition for soothing the nerves and improving sleep as claimed in claim 1, wherein: the microcapsule also comprises a membrane component, wherein the membrane component comprises chitosan and sodium alginate, and the membrane component is coated outside the active component to form the microcapsule.
8. A preparation method of a composition for soothing nerves and improving sleep is characterized by comprising the following steps:
1) mixing materials:
weighing passion fruit extract, spina date seed concentrated powder, lily extract, Griffonia simplicifolia seed extract, chamomile extract and spearmint extract according to the formula amount, uniformly mixing to obtain a mixture, adding deionized water, and uniformly stirring to obtain a mixed solution;
2) refining and homogenizing:
refining the mixed solution by a colloid mill;
homogenizing and refining the refined mixed solution by a homogenizer;
spray drying the homogenized solution to obtain an active component;
3) microencapsulation: mixing the active component with chitosan, sodium alginate, water and edible surfactant, and spray drying to obtain microcapsule for improving bone health.
9. The preparation method of the composition for soothing the nerves and improving sleep according to claim 8, wherein the composition comprises the following components: in the microencapsulation step, chitosan, sodium alginate and active components are added and mixed evenly, and then the mixture is stood for 20 to 40min and then spray-dried.
10. The preparation method of the composition for soothing the nerves and improving sleep according to claim 8, wherein the composition comprises the following components: in the microencapsulation step, the particle size of the microcapsule obtained by spray drying is 40-60 meshes.
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