CN115252500A - 含有牡丹提取物的护肤组合物及其应用 - Google Patents
含有牡丹提取物的护肤组合物及其应用 Download PDFInfo
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- CN115252500A CN115252500A CN202211027972.0A CN202211027972A CN115252500A CN 115252500 A CN115252500 A CN 115252500A CN 202211027972 A CN202211027972 A CN 202211027972A CN 115252500 A CN115252500 A CN 115252500A
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- peony
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Abstract
本发明属于医药化妆品领域，具体涉及一种包含牡丹提取物的护肤组合物及其用途。所述的护肤组合物包括下述重量份的原料：牡丹肽1‑5份、牡丹黄酮1‑5份、牡丹籽油20‑200份，进一步还可以包含其他辅料。本发明的组合物可用于化妆品、护发香波、沐浴液、洗手液中，其能够抑制酪胺酸酶的活性和细胞黑色素的生成，可获得较好的美白效果，也可用于化妆品原料使用，明显改善皮肤表皮细胞循环功能，促进皮肤毛细血管的微循环作用，抑制脂质过氧化作用的进行，改善新陈代谢，牡丹肽、牡丹黄酮和牡丹籽油三者的协同作用下，对黄褐斑、皮肤老化皱纹、皮肤角质硬化脱皮、皮肤皱裂有很好的效果。
Description
技术领域
本发明属于植物提取物技术领域，具体涉及一种含有牡丹提取物的护肤组合物及其应用。
背景技术
牡丹是我国特有的木本名贵花卉，有数千年的自然生长和1500多年的人工栽培历史。牡丹花，花大型美，花朵雍容华贵，被誉为花中之王。牡丹浑身是宝，但仅根和花做为中药材在中国古医书中记载。牡丹美容相对于玫瑰美容来说仍处于相对落后水平。
皮肤白皙水嫩被越来越多的东方女性所推崇，目前上市的皮肤美白剂类产品，越来越多的消费者倾向于有美白功效的含天然植物提取物的化妆品。发明人本着“国花”养国人的理念，希望研制出美白效果明显，作用温和，安全可靠的含国花牡丹提取物的护肤组合物。
CN103027863A公开了一种含有牡丹提取物的微乳液的制备方法，包括如下步骤：将牡丹提取物与水、氢化卵磷脂和油相混合，剪切混合。这种含有牡丹提取物的微乳液与其他物质复配，可调节与黑色素形成有关基因、与皮肤保湿能力有关基因、与改善皮肤衰老程度有关基因和与舒缓皮肤刺激有关基因的表达水平，稳定性好，使用方便，用于制备化妆品和护肤品，可有效保湿、减少黑色素、改善皮肤衰老和舒缓皮肤刺激。
但其牡丹提取物并未量化各类物质的含量，简单的一步提取无法使各类有效物质的协同配合达到最佳效果，且根据不同的牡丹花品种或部位，提取的物质含量不稳定，无法实现产业化应用。
CN105078875A公开了一种含牡丹提取物的化妆品及其制备方法。本发明的含牡丹提取物的化妆品，其特征在于，所述的化妆品包括牡丹籽油；还包括牡丹籽提取物和牡丹根提取物。本发明的有益效果在于，采用本发明的方法及原料制得的化妆品，将牡丹提取物、牡丹籽油与其它的原料如月见草油、红花籽油、金缕梅提取物、珍珠粉提取物等联合作用于皮肤，其消炎抗过敏效果较好，而且对于增加皮肤的细腻度及提升皮肤的美白度和收缩毛孔具有良好的效果。
但其牡丹提取物同样存在未量化牡丹提取物各类物质的含量，且其化妆品不能含其他植物提取物，无单因素试验证明牡丹提取物和牡丹籽油的效果，且根据不同的牡丹花品种或部位，提取的物质含量不稳定，无法实现产业化应用。
因此，如何发挥牡丹提取物在护肤应用方面的最大效用是丞待解决的问题。
发明内容
为了解决上述的技术问题，本发明提供了一种含有牡丹提取物的护肤组合物，采用牡丹肽、牡丹黄酮、牡丹籽油护肤组合物，利用牡丹籽油中的抗氧化功效，能够预防及治疗多种皮肤问题，配合牡丹黄酮强渗透力、强溶解性等特点，经皮肤、经络、穴位渗透吸收，协同牡丹肽的营养滋补作用，实现了多种护肤效果。
本发明的目的之一在于解决牡丹籽油单一使用护肤效果差的技术问题；
本发明的第二个目的在于，提供一种美白效果明显，作用温和，安全可靠的含国花牡丹提取物的护肤组合物，也可作为化妆品原料使用。
本发明的技术方案如下：
一种含有牡丹提取物的护肤组合物，包括下述重量份数的组分：牡丹籽油50～200份、牡丹黄酮1～5份、牡丹肽1～5份，还包括组分A，所述组分A包括媒介物、活性成分和辅料，组分A为11～420份。
优选的，牡丹肽1～4份、牡丹黄酮1～4份、牡丹籽油50～100份；
优选的，牡丹肽1～3份、牡丹黄酮1～3份、牡丹籽油60～100份；
优选的，牡丹肽1～2份、牡丹黄酮1～2份、牡丹籽油70～100份；
优选的，牡丹肽1～2份、牡丹黄酮1～2份、牡丹籽油80～120份；
优选的，牡丹肽1～2份、牡丹黄酮1～2份、牡丹籽油100～150份；
优选的，牡丹肽1～2份、牡丹黄酮1～2份、牡丹籽油100～200份；
优选的，牡丹肽1份、牡丹黄酮2份、牡丹籽油51份；
优选的，牡丹肽1份、牡丹黄酮2份、牡丹籽油52份；
优选的，牡丹肽1份、牡丹黄酮2份、牡丹籽油53份；
优选的，牡丹肽1份、牡丹黄酮2份、牡丹籽油54份；
优选的，牡丹肽1份、牡丹黄酮2份、牡丹籽油55份；
优选的，牡丹肽1份、牡丹黄酮2份、牡丹籽油56份；
优选的，牡丹肽1份、牡丹黄酮2份、牡丹籽油57份；
优选的，牡丹肽1份、牡丹黄酮2份、牡丹籽油58份；
优选的，牡丹肽1份、牡丹黄酮2份、牡丹籽油59份；
优选的，牡丹肽1份、牡丹黄酮2份、牡丹籽油60份；
优选的，牡丹肽1份、牡丹黄酮4份、牡丹籽油70份；
优选的，牡丹肽1份、牡丹黄酮4份、牡丹籽油80份；
优选的，牡丹肽1份、牡丹黄酮4份、牡丹籽油90份；
优选的，牡丹肽1份、牡丹黄酮4份、牡丹籽油100份；
优选的，牡丹肽1份、牡丹黄酮4份、牡丹籽油105份；
优选的，牡丹肽1份、牡丹黄酮4份、牡丹籽油110份；
优选的，牡丹肽1份、牡丹黄酮4份、牡丹籽油120份；
优选的，牡丹肽1份、牡丹黄酮4份、牡丹籽油130份；
优选的，牡丹肽1份、牡丹黄酮4份、牡丹籽油150份；
优选的，牡丹肽1份、牡丹黄酮5份、牡丹籽油100份；
优选的，牡丹肽1份、牡丹黄酮5份、牡丹籽油110份；
优选的，牡丹肽1份、牡丹黄酮5份、牡丹籽油120份；
优选的，牡丹肽1份、牡丹黄酮5份、牡丹籽油130份；
优选的，牡丹肽1份、牡丹黄酮5份、牡丹籽油140份；
优选的，牡丹肽1份、牡丹黄酮5份、牡丹籽油150份；
优选的，牡丹肽1份、牡丹黄酮5份、牡丹籽油160份；
优选的，牡丹肽1份、牡丹黄酮5份、牡丹籽油170份；
优选的，牡丹肽1份、牡丹黄酮5份、牡丹籽油180份；
优选的，牡丹肽1份、牡丹黄酮5份、牡丹籽油190份；
优选的，牡丹肽1份、牡丹黄酮5份、牡丹籽油200份。
本发明还提供所述护肤组合物在护肤化妆品中的应用，本发明的护肤化妆品组合物还包含组分A护肤化妆品中常用的成分，其中包括媒介物、活性成分和辅料等，组分A是本领域已知的，本领域技术人员可根据需要具体选择其类型和用量。通常，组分A在本发明组合物中的含量为50-90％重量。
其中，所述媒介物为稀释剂、分散剂或载体等，所述媒介物都是本领域已知的，本领域技术人员可根据需要具体选择其类型和用量。例如，所述媒介物包括但不限于乙醇、双丙甘醇、丁二醇等。通常，在本发明组合物中，所述媒介物占组分A总重量的5-30％。
其中，所述活性成分包括但不限于润肤剂、保湿剂、皮肤调理剂等。所有这些活性成分都是本领域已知的，本领域技术人员可根据需要具体选择其类型和用量。
其中，所述润肤剂包括但不限于橄榄油、澳洲坚果油、甜杏仁油、葡萄籽油、鳄梨油、玉米油、芝麻油、大豆油、花生油、白池花籽油、红花籽油、狗牙蔷薇果油、刺阿干树仁油、霍霍巴籽油、向日葵籽油、毛瑞榈果油、角鲨烷、棕榈酸乙基己酯、肉豆蔻酸异丙酯、氢化聚异丁烯、异十六烷、异十二烷、碳酸二乙基己酯、碳酸二辛酯、月桂酰肌氨酸异丙酯、异壬酸异王酯、氢化聚癸烯、辛基聚甲基硅氧烷、鲸蜡基聚二甲基硅氧烷、环五聚二甲基硅氧烷、甘油三(乙基己酸)酯、鲸蜡醇乙基己酸酯、双-二乙氧基二甘醇环己烷1,4-二羧酸酯、辛酸/癸酸甘油三酯、油醇芥酸酯、辛基十二醇肉豆蔻酸酯、辛基十二醇、聚二甲基硅氧烷、等的一种或多种。本发明所述的固体润肤剂包括但不限于鲸蜡醇、硬脂醇、鲸蜡硬脂醇、山嵛醇、鲨肝醇、月桂酸、肉豆蔻酸、棕榈酸、硬脂酸、蜂蜡、小烛树蜡、巴西棕榈蜡、羊毛脂、地蜡、霍霍巴籽蜡、石蜡、微晶蜡、氢化米糠蜡、氢化椰油甘油酯类、甘油山嵛酸酯/二十酸酯、肉豆蔻醇肉豆蔻酸酯、双-二甘油多酰基己二酸酯-2、牛油果树果脂、木鲁星果棕籽脂等中的一种或多种，同样的，所述润肤剂在所述组合物中的含量是本领域已知的。通常，在本发明组合物中，所述润肤剂占组分A总重量的0.5-50％重量。
所述保湿剂包括但不限于甘油、双甘油、聚乙二醇-8、聚乙二醇-32、甲基葡糖醇聚醚-10、甲基葡糖醇聚醚-20、PEG/PPG-17/6共聚物、丁二醇、丙二醇、1,3-丙二醇、双丙甘醇、1,2-戊二醇、甘油聚醚-7、甘油聚醚-26、甘油葡糖苷、海藻糖、鼠李糖、甘露糖、棉子糖、PPG-10甲基葡糖醚、PPG-20甲基葡糖醚、PEG/PPG/聚丁二醇-8/5/3甘油、蔗糖、甜菜碱、赤藓醇、木糖醇、尿素、甘油聚醚-5乳酸酯、透明质酸钠、聚谷氨酸钠、水解小核菌胶、出芽短梗酶多糖、银耳多糖、酸豆籽多糖等中的一种或多种。所述保湿剂在所述组合物中的含量是本领域已知的。通常，在本发明组合物中，所述保湿剂占组分A总重量的1-30％重量。
所述皮肤调理剂可包括用于具有保湿、抗皱、祛斑、祛痘、控油等功效的活性成分，包括但不限于曲酸、抗坏血酸、抗坏血酸葡糖苷、熊果苷、传明酸、烟酰胺、植物甾醇、植物甾醇/山嵛醇/辛基癸醇月桂酰谷氨酸酯、苯乙基间苯二酚、姜黄根提取物、白桦树皮提取物、神经酰胺2、神经酰胺3、乙酰植物鞘氨醇、白藜芦醇、花榈木树皮提取物、毛喉鞘蕊花根提取物、胡椒籽提取物、泛醌、胆甾醇、胆甾醇硬脂酸酯、抗坏血酸二棕榈酸酯、生育酚(维生素E)、生育酚乙酸酯、红没药醇、抗坏血酸四异棕榈酸酯、吡哆素二辛酸酯、吡哆素二棕榈酸酯、视黄醇棕榈酸酯、植物甾醇/辛基十二醇月桂酰谷氨酸酯、双-山嵛醇/异硬脂醇/植物甾醇二聚亚油醇二聚亚油酸酯、植物甾醇澳洲坚果油酸酯、各种肽类、各种植物提取物等中的一种或多种。所述皮肤调理剂在所述组合物中的含量是本领域已知的。通常，在本发明组合物中，所述皮肤调理剂占组分A总重量的0-50％重量。
所述辅料包括但不限于乳化剂、增稠剂、防腐剂、香料等。所有这些辅料成分都是本领域已知的，本领域技术人员可根据需要具体选择其类型和用量。
所述乳化剂包括但不限于鲸蜡硬脂醇橄榄油酸酯、山梨坦橄榄油酸酯、聚山梨醇酯-60、聚山梨醇酯-80、甲基葡糖倍半硬脂酸酯、PEG-20甲基葡糖倍半硬脂酸酯、PEG-40氢化蓖麻油、PPG-26-丁醇聚醚-26、PEG-4聚甘油-2硬脂酸酯、PEG-60氢化蓖麻油、硬脂醇聚醚-2、硬脂醇聚醚-21、PPG13-癸基十四醇聚醚-24、鲸蜡硬脂基葡糖苷、PEG100硬脂酸酯、甘油硬脂酸酯、甘油硬脂酸酯SE、椰油基葡糖苷、鲸蜡硬脂醇聚醚-25、PEG-40硬脂酸酯、聚甘油-3甲基葡糖二硬脂酸酯、甘油硬脂酸酯柠檬酸酯、聚甘油-10硬脂酸酯、聚甘油-10肉豆蔻酸酯、聚甘油-10二油酸酯、聚甘油-10月桂酸酯、聚甘油-10异硬脂酸酯、聚甘油-10油酸酯、聚甘油-10二异硬脂酸酯、聚甘油-6月桂酸酯、聚甘油-6肉豆蔻酸酯、蔗糖硬脂酸酯、蔗糖多硬脂酸酯等中的一种或多种。所述乳化剂在所述组合物中的含量是本领域已知的。通常，在本发明组合物中，所述乳化剂占组分A总重量的0.5-10％。
所述增稠剂包括但不限于卡波姆类、丙烯酸(酯)类及其衍生物、黄原胶、阿拉伯胶、聚乙二醇-14M、聚乙二醇-90M、琥珀酰聚糖、羟乙基纤维素、羟丙基纤维素、羟丙基甲基纤维素等高分子聚合物中的一种或多种。所述增稠剂在所述组合物中的含量是本领域已知的。通常，在本发明组合物中，所述增稠剂占组分A总重量的0.1～10％重量。
例如，所述防腐剂包括但不限于羟苯甲酯、羟苯丙酯、苯氧乙醇、苯甲醇、苯乙醇、双(羟甲基)咪唑烷基脲、山梨酸钾、苯甲酸钠、氯苯甘醚、脱氢乙酸钠等中的一种或多种。所述防腐剂在所述组合物中的含量是本领域已知的。通常，在本发明组合物中，所述防腐剂占组分(C)总重量的0.01-2％重量。
例如，所述防腐剂包括但不限于羟苯甲酯、羟苯丙酯、苯氧乙醇、苯甲醇、苯乙醇、双(羟甲基)咪唑烷基脲、山梨酸钾、苯甲酸钠、氯苯甘醚、脱氢乙酸钠等中的一种或多种。所述防腐剂在所述组合物中的含量是本领域已知的。通常，在本发明组合物中，所述防腐剂占组分(C)总重量的0.01-2％重量。
本发明的护肤化妆品组合物可以通过本领域已知的任何合适的方法制备。例如，使用化妆品领域中常用的溶解槽、乳化锅、分散器、输送泵等设备制备。制备时先将水溶性物质投入水相溶解釜，将油溶性物质投入油相溶解釜，将两个釜的温度加热至约80℃，其中对于易结块的原料，可先用分散器将其预分散。待溶解完成后将油相和水相输送至乳化锅中，均质乳化约5-15分钟。乳化完成后将料体温度降至常温，加入任选的香精、防腐剂等，并视需要调节产物的pH。相关检测指标都合格后方可灌装出货。以上制备方法可进行删减或调整，可根据需要制备膏霜、乳液、精华、洁面等剂型。
本发明中，牡丹籽油中，VA、VE、尼克酸、胡萝卜素、不饱和脂肪酸含量丰富，在一个优选的实施方案中，本发明提供一种具有下述配方的护肤组合物，对皮肤具有极好的营养护理作用，可明显改善皮肤表皮细胞循环功能，促进皮肤毛细血管的微循环作用，抑制脂质过氧化作用的进行，改善新陈代谢，延缓皮肤衰老过程，有抗皱、保湿美白作用，使用后皮肤光滑轻松，对黄褐斑、皮肤老化皱纹、皮肤角质硬化脱皮、皮肤皱裂有很好的效果，具体如下：
表1优选成分方案
其中，经分析，各类主要物质功效如下(常用物质不再赘述)：
1.牡丹籽油可有效抑制黑色素形成，淡化已生斑点；
2.具抗辐射作用，改善皮肤过敏状况；
3.防止妊娠纹产生；
4.延缓皱纹发展进程：对于面部表情肌运动减少或消失，出现额头纵横褶纹时，使用后能逐渐得到恢复；
5.促进血液循环、加速新陈代谢；
6.美容养颜：富含维他命a/d(α-胡萝卜素)等多种营养元素；
7.滋润皮肤、祛痘控油。
本发明利用牡丹黄酮的强渗透力、强溶解性等特点，经皮肤、经络、穴位渗透吸收产生作用：①抑制酪氨酸酶的活性；②阻碍黑素细胞的生长；③刺激细胞产生溶酶体吞噬黑色素，美白疗效显著，且安全无刺激，无毒副作用，适宜长期使用。本发明的牡丹黄酮主要有黄酮、黄酮醇及花色苷类：其提取方法包括但不限于溶剂提取法，超声辅助提取法，酶解法，闪式提取法。
本发明中的牡丹肽具有镇痛、抗炎、解热和抑制黑色素的作用，相关研究表明：
(1)添加0.25％于美容霜中作为面膜调液，能促进面部皮肤血液循环，活化衰老的表皮细胞，消除皱纹，去斑，润肤美容，增强皮肤光洁度，有效补给肌肤营养并防止老化及皱纹产生等功能，在日常护理的基础上使用可收获更佳的护肤效果；特别适合干性、敏感性或脆弱易红肿部位(例如眼部)使用；
(2)添加0.3％于香波中，能去屑，止痒，调理头发，保湿，柔软，光亮，促进头发生长。
(3)添加0.25％于面膜液中，能使皮肤白嫩，防老，对青春痘效果尤佳。
(4)添加0.3％于香浴液、香皂中，能促进皮肤新陈代谢，改善肤色，去粉刺。
(5)添加0.3％于牙膏、含漱液中，能消肿止痛，防治龋齿，掩盖口臭，清洁口腔等作用。
具体实施方式
实施例1
一种含有牡丹提取物的护肤组合物，包括下述重量份数的组分：牡丹肽1份、牡丹黄酮5份、牡丹籽油100份。
通过添加本发明的提取物，制备了一种具有美白效果的护肤品及使用该产品所制得的护肤组合物，它是由牡丹萃取物(牡丹肽、牡丹黄酮)与牡丹籽油一起调配制备而形成，也可以根据需要加入不同的功能因子或者植物色素、维生素c和抗氧化剂进行复方精华添加而成；并且经过对比实验证明:牡丹萃取物+芦荟凝胶(包括玫瑰花水)均可抑制酪胺酸酶活性和黑色素的形成从而达到高效美白效果，在此基础上又增加了紫外线吸收剂和防晒剂，这样就构成了美白类护理品，适应各种肌肤人群使用，更好地保持皮肤原来的光泽。
其中，牡丹肽以水酶解法制备，牡丹黄酮以水醇法萃取；牡丹籽油则是以精炼牡丹籽经压榨后制得。本发明产品具有美白效果，可抑制酪氨酸酶活性、减少黑色素生成及分解已形成的黑斑。适用于面部皮肤，亦可作眼睑等处使用。
表2实施例1护肤品的具体成分
实施例2
一种含有牡丹提取物的护肤组合物，包括下述重量份数的组分：牡丹肽1份、牡丹黄酮3份、牡丹籽油100份。
本发明的牡丹黄酮含有多种黄烷酮、黄酮醇、花色苷等，现对其进行理化性质检测，牡丹花中黄酮类化合物的分析测定方法主要有紫外分光光度法，高效液相色谱法，薄层层析法等：牡丹花提取液具有良好的抗氧化活性和清除自由基的能力，研究表明其抗氧化能力与多酚、黄酮的含量具有一定的相关性。
本品为深红色的澄明溶液；气特异，味微苦而甜后稍带涩。
(1)取本品约10mg加水5ml稀释后，依次置试管中，各加等量盐酸2ml，再依法制成每1ml各加0.5mg氯化铁试液2ml及2％三羟甲基丙烷胺盐酸盐缓冲液(pH9.5)10ml作供试品溶液，另精密称定该溶液与对照品溶液相差不得超过3-4倍。如果两者均显绿色，则证明该提取物中还含有黄酮类成分，可以确定其检出限。
(2)在紫外光灯下观察：
①反应产生荧光蓝色斑点或荧光白色斑点；
②同一吸收池内，将样品滴加上述硫代乙醛处理的醋酸锌溶液至无限淡。
在70％的乙醇中，料液比为1:20，水浴温度为30℃加热至沸后5分钟，在频率为22kHz的超声波下处理10min，牡丹花中总黄酮提取率可达90.5％，然后取2-3ml样液滴于滤纸上或者干燥的薄膜片上，置紫外光灯下观察荧光斑点和颜色变化情况，每个试样应不少于3处，同时记录各种黄酮类成分的染料吸收波长(λ值)及其相对强度随浓度增大而减小的程度。
经检测，黄酮物质含量为1.03mg/g，以HPLC-DAD-ESI-MS联用检测，分析芍药-3-0-葡萄糖苷、矢车菊-3,5-0-二葡萄糖苷、天竺葵-3,5-0-二葡萄糖苷、矢车菊-3-0-葡萄糖苷、芍药-3,5-0-二葡萄糖苷等其余物质峰形较多，不再一一分析。
实施例3
一种含有牡丹提取物的护肤组合物，包括下述重量份数的组分：牡丹肽1份、牡丹黄酮5份、牡丹籽油50份。
实施例4
一种含有牡丹提取物的护肤组合物，包括下述重量份数的组分：牡丹肽1份、牡丹黄酮5份、牡丹籽油200份。
实施例5
发明人参考文献雷铁池在中华皮肤科杂志上发表的《8-甲氧补骨脂素对小鼠黑素瘤细胞黑素生成的调节及相关信号转导研究》，针对实施例和甘草黄酮、对B16F10细胞酪胺酸酶的活性和黑色素含量进行了实验，实验结果见表3。
表3实施例1和2的酪胺酸酶的活性和黑色素含量对照表
| 样品浓度 | 酪胺酸酶的活性％ | 黑色素含量％ |
| 空白对照 | 100.0(3) | 100.0(3) |
| 甘草黄酮(125μg/ml) | 47.84±5.05(3) | 41.52±8.18(3) |
| 实施例1(125μg/ml) | 42.84±4.85(3) | 38.82±6.15(3) |
| 实施例2(125μg/ml) | 46.64±3.67(3) | 40.38±5.18(3) |
实施例6
发明人根据实施例3添加10％的护肤组合物制作护肤产品，对使用产品后皮肤颜色含量进行测试
选取50名志愿者对产品使用前、产品使用4周和8周后，对面部色斑区、非色斑区及左右前臂外侧进行皮肤颜色测试，结果见表4。
表4产品使用前、产品使用4周及8周后皮肤颜色(L*值和ITAo值)统计结果
统计方法：t检验显著性："+":显著性差异(p≤0.05)；"--":非显著性差异(p>0.05)
由表4看出，与初始值比较，在产品使用4周及8周后，面部斑区L*值分别显著增加2.54和3.88，ITAo值显著增加3.03和4.9；在产品使用8周后面部非斑区L*值和ITAo值分别显著增加4.66和3.03。与非斑区比较，在产品使用4周后，面部斑区L*值和ITAo值呈显著性改善。
与初始值比较，在产品使用4周及8周后，手臂产品区L*值分别显著增加2.18和4.34，ITAo值分别显著增加3.89和6.65，手臂空白区L*值分别未显著增加-0.15和0.39，ITAo值分别未显著增加0.33和0.29；与空白区相比，手臂产品区L*值和ITAo值在产品使用4周和8周后均呈显著性改善。
实施例7
发明人根据实施例1添加10％制作护肤产品，对使用产品后皮肤水分含量进行测试
选取50名志愿者对产品使用前、产品使用4周和8周后，对随机一侧面颊及左右前臂内侧进行皮肤水分含量测试，结果见表3。
表5产品使用前，产品使用4周及8周后皮肤水分统计结果
统计方法：t检验显著性：“+”:显著性差异(p≤0.05)；“--”；非显著性差异(p>0.05)
由表5可见，与初始值相比，使用产品4周和8周后后面颊水分含量显著性增加；使用产品4周和8周后手臂产品区皮肤水分含量均显著性增加，空白区皮肤水分含量均显著性降低；与空白区比较，使用产品4周和8周后面颊、手臂产品区水分含量均呈显著性改善。
实施例8
对实施例3的样品进行抗衰老实验，具体如下：
MMP-1是降解I型和III型胶原最主要的酶，皮肤细胞过量表达MMP-1会导致真皮层细胞外基质被破坏，尤其是胶原纤维和弹力纤维的正常结构，因此MMP-1是导致皮肤出现皱纹、细纹等衰老症状最主要的酶，Procollagen-1的含量同样是反映细胞老化情况的重要指标；通过检测二者的含量，评估受试物的抗衰老作用。
表6样品对细胞MMP-1水平的影响
由表6中的数据可知，模型组(M)与阴性对照组(NT)相比，MMP-1相对含量明显升高(P<0.05)；阳性对照组与模型组相比，MMP-1相对含量明显降低(P<0.05)，提示造模成功；在3号样本组(TA)实施例3牡丹护肤组合物0.85％的浓度下，样品组的MMP-1相对含量与模型组相比显著降低(P<0.05)。
表7样品对细胞Procollagen-1水平的影响
由表7中的数据可知，模型组(M)与阴性对照组(NT)相比，Procollagen-1相对含量明显降低(P<0.05)；阳性对照组与模型组相比，Procollagen-1相对含量明显升高(P<0.05)，提示造模成功；在3号样本组(TA)实施例3牡丹护肤组合物0.85％的浓度下，样品组的Procollagen-1相对含量与模型组相比显著升高(P<0.05)。
实施例3牡丹护肤组合物样品在此次测试中表现出抗衰老活性。通过抑制MMP-1和提高Procollagen-1相对含量，可以起到皮肤出现皱纹、细纹等衰老问题。
Claims (10)
1.一种含有牡丹提取物的护肤组合物，其特征在于，包括下述重量份数的组分：牡丹籽油50~200份、牡丹黄酮1~5份、牡丹肽1~5份。
2.如权利要求1所述的一种含有牡丹提取物的护肤组合物，其特征在于，所述牡丹肽的分子量为500~10000道尔顿。
3.如权利要求1所述的一种含有牡丹提取物的护肤组合物，其特征在于，所述牡丹黄酮由水或乙醇提取。
4.如权利要求1所述的一种含有牡丹提取物的护肤组合物，其特征在于，所述护肤组合物还包括组分A，所述组分A包括媒介物、活性成分和辅料，所述辅料包括水、乳化剂、增稠剂、防腐剂和香料中的至少一种，所述媒介物为稀释剂、分散剂或载体中的至少一种，所述活性成分选自润肤剂、保湿剂、皮肤调理剂。
5.如权利要求1所述的一种含有牡丹提取物的护肤组合物，其特征在于，所述的护肤组合物包括下述重量份的原料：牡丹肽1~2份、牡丹黄酮3~5份、牡丹籽油100~200份。
6.如权利要求1所述的一种含有牡丹提取物的护肤组合物，其特征在于，所述的护肤组合物包括下述重量份的原料：牡丹肽1~2份、牡丹黄酮3~5份、牡丹籽油150~200份。
7.如权利要求1所述的一种含有牡丹提取物的护肤组合物，其特征在于，所述的护肤组合物包括下述重量份的原料：牡丹肽1份、牡丹黄酮3份、牡丹籽油200份。
8.权利要求1所述的一种含有牡丹提取物的护肤组合物在制备护肤化妆品中的应用。
9.如权利要求8所述的应用，其特征在于，所述护肤组合物在护肤化妆品中的质量比为1%-50%。
10.一种护肤化妆品，其特征在于，所述护肤化妆品由如权利要求1所述的护肤组合物和辅料10-20份组成；所述化妆品选自美容霜、面膜液、乳液。
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| CN117224445B (zh) * | 2023-10-20 | 2024-03-29 | 妆莱(广州)生化科技有限公司 | 含牡丹根皮提取物的香水柠檬型精油及制备工艺与应用 |
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