CN115252454A - Sunscreen cream and preparation method thereof - Google Patents

Abstract

The application relates to the technical field of cosmetics, in particular to sunscreen cream and a preparation method thereof, wherein the sunscreen cream is prepared from the following raw materials in percentage by weight: 1 to 2 percent of shea butter, 0.6 to 1 percent of glyceryl oleate citrate, 2.1 to 3.1 percent of olive oil emulsified wax, 3.7 to 4.1 percent of glycerol, 3.7 to 4.1 percent of tuckahoe extract, 3.1 to 3.5 percent of seabuckthorn fruit extract, 2.4 to 2.8 percent of honeysuckle extract, 3.7 to 4.1 percent of purslane extract, 3.7 to 4.1 percent of angelica extract, 3.7 to 4.1 percent of radix scutellariae extract, 0.03 to 0.05 percent of sodium dehydroacetate, 37.1 to 41.1 percent of carbomer, 0.5 to 5 percent of tetrahydropyrimidine and/or hydroxyl tetrahydropyrimidine, and the balance of deionized water. The product has effects of resisting ultraviolet, reducing skin injury, and keeping moisture.

Description

Sunscreen cream and preparation method thereof

Technical Field

The invention belongs to the technical field of cosmetics, and particularly relates to sunscreen cream and a preparation method thereof.

Background

The skin is a protective layer of the human body and, with age, is subject to aging by certain extrinsic (e.g., chemicals, toxins, pollutants and ultraviolet radiation) and intrinsic factors (e.g., genetic mutations, cellular metabolism and hormonal changes). Research shows that ultraviolet radiation comprises three wavelength ranges of UVA, UVB and UVC, wherein the UVC is absorbed by an ozone layer in the atmosphere and mainly produces the UVA and the UVB which damage human skin. UVA can penetrate into tissues below dermis to destroy the fine structures in the skin such as collagen, elastic fiber tissues and the like, so that the skin is loosened to generate wrinkles; in addition, UVA oxidizes the reduced melanin pigment in the epidermis to directly tan the skin, which over time causes photoaging of the skin, sagging of the skin and wrinkles. UVB has erythematous effects on the human body, and can promote mineral metabolism and vitamin D formation in the body, but also can cause immediate skin damage, and in the mild case, can cause red swelling of the skin, and in the severe case, can produce erythema and blisters, causing phenomena such as skin tanning and sunburn. In addition, UVB can cause cellular DNA damage and skin tumors, immunosuppression and even skin cancer, and thus effective uv protection is essential. Sunscreen creams are products that combine ingredients to protect the skin by absorbing, blocking, or scattering ultraviolet radiation.

Currently, sunscreen creams used in sunscreen cosmetics on the market are roughly classified into physical sunscreens, chemical sunscreens and pure natural/botanical sunscreens. Most conventional physical sunblocks work with UVB but are not effective against the longer wavelengths of UVA ultraviolet light, which is increasingly believed to be associated with premature skin aging and skin cancer. And the preparation mainly based on the physical sunscreen cream is greasy, is easy to block pores, and influences the secretion of sweat glands and sebaceous glands of the skin. The chemical sun cream can absorb ultraviolet rays with specific wavelengths and convert light energy into other harmless energy such as heat energy and the like, thereby playing a role in preventing ultraviolet rays; the chemical sun cream is easy to be absorbed by human body, generates toxic and side effect when entering into human body, is easy to be degraded by light and has poor stability. Furthermore, long-term use of chemical sunscreens can cause skin dependency and damage to skin cells and skin structures. The existing part of sunscreen cream in the current market is added with a physical sunscreen agent and a chemical sunscreen agent in order to ensure the sunscreen effect, so that the sunscreen cream is not stable, and has the potential safety hazard of secondarily damaging skin. For example, chinese patent publication No. CN113332197A discloses a plant sunscreen cream and a preparation method thereof, wherein the plant sunscreen cream contains angelica sinensis and radix paeoniae alba as main active ingredients and is free of preservatives, and has no skin irritation and allergy. For another example, chinese patent publication No. CN113351210A discloses a waterproof sunscreen skin care product and a preparation method thereof, wherein the sunscreen skin care product prepared by the invention of chemical sunscreen agent, physical sunscreen agent, anti-inflammatory agent, film-forming agent and other ingredients has the advantages of good sunscreen effect, stable product property, excellent waterproof effect, difficult skin sensitization and the like. For another example, chinese patent publication No. CN110279613B discloses a light-colored melanin sunscreen cream and a preparation method thereof, which is a cross-linked product of polydopamine oligomer and a hydrophilic polymer with thiol, amino or boric acid, and has good biological stability and free radical scavenging ability, and no skin permeation. The various sunscreen creams have certain sunscreen effects due to the addition of physical and/or chemical sunscreen agents, but the long-term use of the sunscreen creams not only affects the secretion of sweat glands and sebaceous glands of the skin, but also has poor stability (physical sunscreen agents). Furthermore, if the skin care composition is used for a long time, the skin is dependent on the composition, and skin cells and skin structures are damaged (chemical sunscreen agents). The pure natural/vegetal sunscreen cream takes no added chemical components as the primary target, takes natural extracts of Chinese prescriptions or plant series as main components, compensates the impermeability of physical sunscreen on the basis of reducing the stimulation of the chemical components, and not only can achieve good sunscreen effect, but also is green and safe.

Disclosure of Invention

Aiming at the problems, the invention provides a sunscreen cream taking tetrahydropyrimidine and/or hydroxyl tetrahydropyrimidine as main components, and a natural sunscreen cream matched with pure natural/botanical extracts, mainly relates to the use of components such as an emulsifier, the sunscreen cream, a humectant, a natural preservative and the like, makes up the impermeability of physical sunscreen on the basis of reducing the stimulation of chemical components, can effectively resist the damage of ultraviolet rays to the skin of a human body, reduces the skin damage, and is green and safe. Meanwhile, the invention also provides a preparation method of the sunscreen cream, which is prepared by mixing and emulsifying water-phase and oil-phase raw materials and adding other auxiliary materials.

In order to achieve the purpose, the invention adopts the following technical scheme:

tetrahydropyrimidine (Ectoine) and hydroxyl tetrahydropyrimidine (5-hydroxyectoine) are compatible solutes which are synthesized intracellularly by halophilic or halotolerant bacteria and can resist external high-salt stress. Both are neutral, nonionic, low molecular weight, water-binding cyclic amino acid derivatives. They can stabilize cell structure and maintain the activity of biological macromolecules (biomembranes, proteins, enzymes and nucleic acids) under adverse conditions of salt, alkali, heat, freezing, drying, etc. In addition, the abundant C and N contents enable the tetrahydropyrimidines and/or hydroxyl tetrahydropyrimidines to be used as storage energy sources and provide carbon sources or nitrogen sources for cell growth. Experiments prove that Ectoine and 5-hydroxyectoine can prevent the skin from being damaged by ultraviolet UVA and UVB, prevent the loss of water in the skin through the protection effect on protein, and have obvious effects on moisturizing and preventing allergic skin dryness. The mechanism comprises the following steps: forming a protective layer on the cell surface to resist the damage of rays; the effects of protecting, preventing degeneration and repairing proteins and nucleic acids prevent the replication disorder and error of double helix structure caused by intracellular protein degeneration and DNA damage caused by ray radiation, and prevent canceration; combine water molecules to form a water film to play a role in moisturizing. Foreign studies have shown that UVA radiation-induced Reactive Oxygen Species (ROS) production mediates excessive melanin production in skin cells, resulting in pigmentation. Tetrahydropyrimidines may function to decolorize and resist melanogenesis by down-regulating Reactive Oxygen Species (ROS), alpha-melanocyte stimulating hormone (alpha-MSH) production, and pro-opiomelanocortin (POMC) expression in UVA-irradiated human keratinocytes (HaCaT).

And (3) poria cocos extract: the Poria extract has obvious effect in inhibiting tyrosinase, and can inhibit tyrosinase monophenol enzyme and diphenolase activity. The poria cocos extract contains a large amount of pachymaran and poria cocos triterpenes, the existence of a large amount of hydrophilic hydroxyl groups enables the pachymaran to have strong water absorption, emulsibility, high viscosity and good film forming property, and the poria cocos triterpenes can inhibit MDA (malondialdehyde) generation, reduce erythrocyte oxidative damage, eliminate free radicals, inhibit tyrosine monophenolase and diphenolase activities, reduce melanin generation and achieve whitening and freckle removing effects.

And (3) extracting the sea buckthorn fruit: the fructus Hippophae is vinegar Salix fruit and sour fructus Rosae Davuricae. Sea buckthorn is a precious economic forest species containing most natural vitamins in the world at present, the content of vitamin C of the sea buckthorn is far higher than that of fresh jujube and kiwi fruit, so that the sea buckthorn is known as a treasure house of natural vitamins, the sea buckthorn is rich in nutrition and has a good inhibition effect on metalloproteinase, the activation of the metalloproteinase is an index of skin aging, and the inhibition effect is shown by combining the elimination capability of superoxide radical; it also has antibacterial and anti-inflammatory effects.

And (3) honeysuckle extract: the honeysuckle contains a large amount of flavonoid compounds, and the flavonoid compounds can absorb ultraviolet rays with the wavelength of 200-400 nm, particularly UVA and UVB. The flavonoids compounds added in sunscreen cosmetics not only absorb ultraviolet rays, but also have the effects of resisting photoaging, regulating signal pathways of sunburn and the like.

And (3) purslane extract: the purslane has complex components, and the components mainly comprise alkaloid, coumarin compounds, flavonoid, phenols, mushrooms, sterol and other compounds. The herba Portulacae extract has broad-spectrum antibacterial and antiinflammatory effects, and can be used for preventing and treating dermatoses such as skin eczema, allergic dermatitis, and contact dermatitis; the product has good oxygen free radical scavenging ability, which shows that the product has obvious antioxidation function; has good skin moisture keeping effect.

And (3) Chinese angelica extract: the angelica extract contains vitamin A, vitamin B, various organic acids, B-sitosterol and other components, has the functions of resisting ultraviolet rays and whitening skin, and has obvious curative effect on pigmented spots of skin such as faces. When the angelica sinensis also contains high-content ferulic acid, the ferulic acid can reduce UVB-induced lipid peroxidation of human lymphocytes and inhibit UVB-induced generation of glutathione peroxide, oxidative glutathione and the like.

Extract of scutellaria baicalensis georgi: the radix Scutellariae extract can inhibit elastase and eliminate free radicals, thereby accelerating skin metabolism to achieve the effects of increasing skin elasticity and wrinkle resistance; can inhibit dermatitis, enhance skin resistance, and has anti-inflammatory effect; can neutralize released histamine, and has antiallergic effect.

Compared with the prior art, the invention has the following advantages and beneficial effects:

the natural sunscreen cream containing the tetrahydropyrimidine and/or the hydroxyl tetrahydropyrimidine is developed by taking the tetrahydropyrimidine and/or the hydroxyl tetrahydropyrimidine with good moisturizing and ultraviolet-proof functions as main components and matching with natural plant extracting agents such as poria cocos extracting solution and honeysuckle extracting solution, so that the effects of resisting ultraviolet rays, reducing skin damage and moisturizing are achieved, the components are all natural, and secondary damage of some chemical components to skin is effectively avoided.

Detailed Description

In order to make the technical scheme of the invention better understood by those skilled in the art, the invention is further illustrated by the following examples.

A sunscreen cream containing tetrahydropyrimidine and/or hydroxyl tetrahydropyrimidine as main components comprises the following raw materials in percentage by weight: 1 to 2 percent of shea butter, 0.6 to 1 percent of glyceryl oleate citrate, 2.1 to 3.1 percent of olive oil emulsified wax, 3.7 to 4.1 percent of glycerol, 3.7 to 4.1 percent of tuckahoe extract, 3.1 to 3.5 percent of seabuckthorn fruit extract, 2.4 to 2.8 percent of honeysuckle extract, 3.7 to 4.1 percent of purslane extract, 3.7 to 4.1 percent of angelica extract, 3.7 to 4.1 percent of radix scutellariae extract, 0.03 to 0.05 percent of sodium dehydroacetate, 37.1 to 41.1 percent of swollen carbomer and 0.5 to 5 percent of tetrahydropyrimidine and/or hydroxyl tetrahydropyrimidine.

Example 1

The embodiment provides sunscreen cream which is prepared from the following raw materials in percentage by weight: 1.47% of shea butter, 0.73% of glyceryl oleate citrate, 2.44% of olive oil emulsified wax, 2.44% of glycerol, 3.67% of poria cocos extract, 3.06% of sea buckthorn fruit extract, 2.44% of honeysuckle extract, 3.67% of purslane extract, 2.44% of angelica sinensis extract, 2.44% of radix scutellariae extract, 0.037% of sodium dehydroacetate, 73.32% of swollen carbomer and 1.83% of tetrahydropyrimidine.

The emulsifier adopted in the formula of the sunscreen cream is mainly derived from natural plants, and has the advantages of excellent emulsifying effect, high safety, excellent skin feel and good absorption effect.

Example 2

The difference from example 1 is that the formulation of this example is different. Specifically, in this example, 0.915% of tetrahydropyrimidine and 0.915% of hydroxytetrahydropyrimidine were added, respectively.

A sunscreen cream is composed of the following raw materials in percentage by weight: 1.47% of shea butter, 0.73% of glyceryl oleate citrate, 2.44% of olive oil emulsified wax, 2.44% of glycerol, 3.67% of poria extract, 3.06% of seabuckthorn fruit extract, 2.44% of honeysuckle extract, 3.67% of purslane extract, 2.44% of angelica extract, 2.44% of radix scutellariae extract, 0.037% of sodium dehydroacetate, 73.32% of swollen carbomer, 0.915% of tetrahydropyrimidine and 0.915% of hydroxytetrahydropyrimidine.

The tetrahydropyrimidine and/or hydroxyl tetrahydropyrimidine added in the sunscreen cream formula greatly enhances the sunscreen effect of the sunscreen cream, and plant extracting solutions such as honeysuckle extracting solution and poria cocos extracting solution are added, so that the sunscreen cream has a good sunscreen effect, is harmless to human skin and can be used for a long time.

Example 3

The difference compared to example 1 is that the formulation of this example is different.

A sunscreen cream comprises the following components in percentage by weight: 1.47% of shea butter, 0.73% of glyceryl oleate citrate, 2.44% of olive oil emulsified wax, 2.44% of glycerol, 3.67% of poria extract, 3.06% of seabuckthorn fruit extract, 2.44% of honeysuckle extract, 3.67% of purslane extract, 2.44% of angelica extract, 2.44% of radix scutellariae extract, 0.037% of sodium dehydroacetate, 73.32% of swollen carbomer and 1.83% of hydroxytetrahydropyrimidine.

Example 4

The embodiment provides a preparation method of sunscreen cream, which comprises the following steps:

(1) Preparation of the aqueous phase: according to the raw material formula proportion in the embodiment 1, putting glycerol, tuckahoe extract, sea buckthorn fruit extract, honeysuckle extract, purslane extract, angelica extract, radix scutellariae extract, sodium dehydroacetate, swollen carbomer and water deionized water into a super constant temperature water bath box with the temperature of 80 ℃ to be stirred until the materials are dissolved;

(2) Preparation of oil phase: weighing shea butter, glyceryl oleate citrate and olive oil emulsified wax according to the proportion of the raw material formula in the embodiment 1, and placing the mixture in a super constant temperature water bath box at 80 ℃ to stir until the mixture is dissolved;

(3) Respectively slowly adding the water phase to the oil phase along the glass rod, uniformly stirring to obtain a mixture of the oil phase and the water phase, and cooling to room temperature;

(4) Adding appropriate amount of essence into the mixture, homogenizing at 15000r/min for 10min to obtain emulsified mixture, sterilizing, and canning.

Example 5

Compared with example 4, the difference is that the preparation is carried out according to the raw material formula in example 2, and the specific preparation method is as follows:

(1) Preparation of an aqueous phase: according to the raw material formula proportion, putting glycerol, poria cocos extracting solution, sea buckthorn fruit extracting solution, honeysuckle extracting solution, purslane extracting solution, chinese angelica extracting solution, radix scutellariae extracting solution, sodium dehydroacetate, swollen carbomer and water deionized water into a super constant temperature water bath at 85 ℃ and stirring until the materials are dissolved;

(2) Preparation of an oil phase: weighing shea butter, glyceryl oleate citrate and olive oil emulsified wax according to the proportion of the raw material formula, placing the materials in a super constant temperature water bath tank at 85 ℃, and stirring until the materials are dissolved;

(3) Respectively slowly adding the water phase to the oil phase along the glass rod, uniformly stirring to obtain a mixture of the oil phase and the water phase, and cooling to room temperature;

(4) Adding appropriate amount of essence into the mixture, homogenizing at 13000r/min for 20min to obtain emulsified mixture, sterilizing, and canning.

Example 6

Compared with example 4, the difference is that the preparation is carried out according to the raw material formula in example 3, and the specific preparation method is as follows:

(1) Preparation of the aqueous phase: according to the raw material formula proportion, putting glycerol, poria cocos extracting solution, sea buckthorn fruit extracting solution, honeysuckle extracting solution, purslane extracting solution, angelica extracting solution, radix scutellariae extracting solution, sodium dehydroacetate, swollen carbomer and water deionized water into a super constant temperature water bath box with the temperature of 90 ℃ to be stirred until the materials are dissolved;

(2) Preparation of oil phase: weighing shea butter, glyceryl oleate citrate and olive oil emulsified wax according to the proportion of the raw material formula, and placing the materials in a super constant temperature water bath box at 90 ℃ to stir until the materials are dissolved;

(3) Respectively slowly adding the water phase to the oil phase along the glass rod, uniformly stirring to obtain a mixture of the oil phase and the water phase, and cooling to room temperature;

(4) Adding appropriate amount of essence into the mixture, homogenizing at 11000r/min for 30min to obtain emulsified mixture, sterilizing, and canning.

Test example 1

The safety and irritation test results show (table 1): the skin of the applied part of the test guinea pigs coated with the sunscreen cream tested in examples 1 to 3 did not have any reaction after 1 hour, 24 hours, 48 hours, 72 hours, and 96 hours, respectively, and the total score was 0, indicating that the mask was mild, non-irritating, and good in safety.

Population testing (patch test): 20 trial volunteers with healthy skin, with a male-female ratio of 50% and an age of 22-25 years, were selected for the following tests (glucocorticoid and antihistamine medication was avoided 2 weeks before the test). Several layers of gauze were folded to a certain size (1 cm on each side of the square, 1cm diameter of the circle), the test article (sunscreen in examples 1 to 3) was wetted with the gauze, then applied to the inner skin of the forearm, covered with a plastic film, and fixed with a bandage. The skin changes of the applied part were observed after 24h and 48h, respectively. The absence of any reaction at the test site is (-); the skin of the tested part has slight pruritus and redness (+); the skin of the tested part has simple erythema and pruritus (+/-); edema erythema and pimple (++) appear on the skin of the tested part; the skin of the tested part has obvious erythema, pimple and blister (+++), and the results are all negative.

The reference basis of the sensory and physicochemical indexes is ' light industry standard QB/T2872-2017 of the people's republic of China ', and the results are shown in the following table (Table 2). The hygiene index test was performed by the Shanghai Engell test technical service, inc. (Table 3). Analysis shows that the total number of microorganisms (such as bacteria, mold and yeast), representative bacteria (such as faecal coliform, staphylococcus aureus and pseudomonas aeruginosa) and heavy metal concentration (such as arsenic, lead and mercury) are all lower than the national cosmetic specified standard and detection limit, and the method can be used for subsequent application production.

TABLE 1 sunscreen safety and irritation test results

TABLE 2 sensory and physicochemical index test results of sunscreen cream

TABLE 3 requirement of hygienic indexes of sunscreen cream and inspection method

In conclusion, the sunscreen cream provided by the invention has the advantages of stable system of emulsifier and moisturizing, whitening and other functional components, mild property and no stimulation. After the volunteer people use the sunscreen cream, the sunscreen SPF is improved by at least 10 percent, and the effect is good.

The preferred embodiments of the present invention have been described in detail, however, the present invention is not limited to the specific details of the above embodiments, and various changes may be made to the technical solution of the present invention within the technical idea of the present invention, and these simple modifications are included in the protective scope of the present invention.

It should be noted that, in the foregoing embodiments, various specific technical features and steps described in the above embodiments can be combined in any suitable manner, and in order to avoid unnecessary repetition, various possible combinations of the features and steps are not described separately.

In addition, any combination of the various embodiments of the present invention is also possible, and the same should be considered as the disclosure of the present invention as long as it does not depart from the spirit of the present invention.

Claims (3)

1. The sunscreen cream is characterized by comprising the following raw materials in percentage by weight: 1 to 2 percent of shea butter, 0.6 to 1 percent of glyceryl oleate citrate, 2.1 to 3.1 percent of olive oil emulsified wax, 3.7 to 4.1 percent of glycerol, 3.7 to 4.1 percent of tuckahoe extract, 3.1 to 3.5 percent of seabuckthorn fruit extract, 2.4 to 2.8 percent of honeysuckle extract, 3.7 to 4.1 percent of purslane extract, 3.7 to 4.1 percent of angelica extract, 3.7 to 4.1 percent of radix scutellariae extract, 0.03 to 0.05 percent of sodium dehydroacetate, 37.1 to 41.1 percent of carbomer, 0.5 to 5 percent of tetrahydropyrimidine and/or hydroxyl tetrahydropyrimidine, and the balance of deionized water.

2. The sunscreen cream as claimed in claim 1, wherein: the sunscreen cream comprises the following raw materials in percentage by weight: 1.47% of shea butter, 0.73% of glyceryl oleate citrate, 2.44% of olive oil emulsified wax, 2.44% of glycerol, 3.67% of poria cocos extracting solution, 3.06% of sea buckthorn fruit extracting solution, 2.44% of honeysuckle extracting solution, 3.67% of purslane extracting solution, 2.44% of angelica sinensis extracting solution, 2.44% of radix scutellariae extracting solution, 0.037% of sodium dehydroacetate, 73.32% of swollen carbomer, 1.83% of tetrahydropyrimidine and the balance of deionized water.

3. A process for the preparation of a sunscreen as claimed in claim 1 or 2, comprising the steps of:

(1) Preparation of an aqueous phase: according to the formula proportion, putting glycerol, poria cocos extracting solution, sea buckthorn fruit extracting solution, honeysuckle extracting solution, purslane extracting solution, angelica extracting solution, radix scutellariae extracting solution, sodium dehydroacetate, swollen carbomer and deionized water into a super constant temperature water bath box at 80-90 ℃ and stirring until the materials are dissolved;

(2) Preparation of an oil phase: weighing shea butter, glyceryl oleate citrate and olive oil emulsified wax according to the proportion of the formula, placing the mixture in a super constant temperature water bath box at the temperature of 80-90 ℃, and stirring until the mixture is dissolved;

(3) Respectively slowly adding the water phase to the oil phase along the glass rod, uniformly stirring to obtain a mixture of the oil phase and the water phase, and cooling to 40 ℃;

(4) Adding a proper amount of essence into the mixture, homogenizing for 10-30 min at the rotating speed of 11000-15000 r/min to obtain a uniformly emulsified mixture, sterilizing and canning.