CN115244179A - 用于治疗和预防前激肽释放酶相关疾患的组合物和方法 - Google Patents

用于治疗和预防前激肽释放酶相关疾患的组合物和方法 Download PDF

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CN115244179A
CN115244179A CN202180020558.4A CN202180020558A CN115244179A CN 115244179 A CN115244179 A CN 115244179A CN 202180020558 A CN202180020558 A CN 202180020558A CN 115244179 A CN115244179 A CN 115244179A
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human subject
oligomeric compound
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E·施耐德
N·J·瓦伊尼
V·J·亚历山大
L·博尔多
K·纽曼
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Ionis Pharmaceuticals Inc
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Ionis Pharmaceuticals Inc
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    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21034—Plasma kallikrein (3.4.21.34)

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CN202180020558.4A 2020-03-13 2021-03-12 用于治疗和预防前激肽释放酶相关疾患的组合物和方法 Pending CN115244179A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062989427P 2020-03-13 2020-03-13
US62/989,427 2020-03-13
PCT/US2021/022069 WO2021183857A1 (en) 2020-03-13 2021-03-12 Compositions and methods for treating and preventing prekallikrein-associated conditions

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CN115244179A true CN115244179A (zh) 2022-10-25

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CN202180020558.4A Pending CN115244179A (zh) 2020-03-13 2021-03-12 用于治疗和预防前激肽释放酶相关疾患的组合物和方法

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US (2) US20230149438A1 (enExample)
EP (1) EP4118208A4 (enExample)
JP (2) JP7795467B2 (enExample)
KR (1) KR20220152569A (enExample)
CN (1) CN115244179A (enExample)
AU (2) AU2021233914B2 (enExample)
BR (1) BR112022016167A2 (enExample)
IL (1) IL295631B1 (enExample)
MX (1) MX2022011205A (enExample)
WO (1) WO2021183857A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9670492B2 (en) 2013-08-28 2017-06-06 Ionis Pharmaceuticals, Inc. Modulation of prekallikrein (PKK) expression

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105517556A (zh) * 2013-08-28 2016-04-20 Ionis制药公司 前激肽释放酶(pkk)表达的调节
US20170183661A1 (en) * 2014-05-01 2017-06-29 Ionis Pharmaceuticals, Inc. Compositions and methods for modulating pkk expression
WO2018148449A1 (en) * 2017-02-08 2018-08-16 Ionis Pharmaceuticals, Inc. Modulation of kallikrein b1 (klkb1) for treatment of headache
CN108602893A (zh) * 2015-12-11 2018-09-28 戴埃克斯有限公司 血浆激肽释放酶抑制剂及其治疗遗传性血管性水肿发作的用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2982752T3 (es) * 2015-10-22 2024-10-17 Iltoo Pharma Composiciones farmacéuticas de il-2
LT4119569T (lt) * 2015-11-06 2024-09-25 Ionis Pharmaceuticals, Inc. Konjuguoti priešprasmiai junginiai, skirti panaudoti terapijoje

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105517556A (zh) * 2013-08-28 2016-04-20 Ionis制药公司 前激肽释放酶(pkk)表达的调节
US20170183661A1 (en) * 2014-05-01 2017-06-29 Ionis Pharmaceuticals, Inc. Compositions and methods for modulating pkk expression
CN108602893A (zh) * 2015-12-11 2018-09-28 戴埃克斯有限公司 血浆激肽释放酶抑制剂及其治疗遗传性血管性水肿发作的用途
WO2018148449A1 (en) * 2017-02-08 2018-08-16 Ionis Pharmaceuticals, Inc. Modulation of kallikrein b1 (klkb1) for treatment of headache

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Publication number Publication date
BR112022016167A2 (pt) 2022-10-04
IL295631B1 (en) 2026-08-01
AU2026203664A1 (en) 2026-05-28
WO2021183857A1 (en) 2021-09-16
EP4118208A1 (en) 2023-01-18
AU2021233914A1 (en) 2022-09-08
JP2026048915A (ja) 2026-03-17
MX2022011205A (es) 2022-09-19
US20230149438A1 (en) 2023-05-18
IL295631A (en) 2022-10-01
JP7795467B2 (ja) 2026-01-07
AU2021233914B2 (en) 2026-04-30
US20260158051A1 (en) 2026-06-11
EP4118208A4 (en) 2025-03-12
KR20220152569A (ko) 2022-11-16
JP2023519501A (ja) 2023-05-11

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