CN115154509B - Foot bath and comfort slow-release powder and preparation method thereof - Google Patents
Foot bath and comfort slow-release powder and preparation method thereof Download PDFInfo
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Abstract
The invention discloses foot bath relaxing slow-release powder. The invention discloses a preparation method of the foot bath Shutong slow release powder, which comprises the following steps: (1) Mixing Saviae Miltiorrhizae radix, fructus Gardeniae, fructus Piperis Longi, carthami flos, and semen plantaginis, lyophilizing, pulverizing at low temperature, adding dispersant into oil, and stirring for 10-30min to obtain superfine Chinese medicinal powder dispersion; (2) Adding zein and water-dispersible carbon microspheres into ethanol water solution, adding superfine Chinese medicinal powder dispersion into the water solution under stirring, stirring at room temperature for 10-30min, heating to 50-70deg.C, removing ethanol in the system under stirring, washing, and vacuum drying to obtain foot bath sustained release powder. The invention not only can slowly release the traditional Chinese medicine powder in hot water, but also has good slow release effect, the slow release effect of the traditional Chinese medicine powder is long, and the external application is carried out for 2-3 courses of treatment, so that the foot fungus infection is cured, and the effect of thoroughly radically curing the foot fungus is achieved by consolidating and removing the medicine without rebound.
Description
Technical Field
The invention relates to the technical field of foot baths, in particular to foot bath relaxing slow release powder and a preparation method thereof.
Background
Currently, foot bath therapy is a unique way for people to perform health care or special treatment. The cold water foot bath can excite nerves, stimulate cardiovascular functions, strengthen physique and improve the adaptability of the body to the external environment. The hot water foot bath has the effects of dilating blood vessel, promoting blood circulation, enhancing metabolism, diminishing inflammation, relieving pain, relieving itching, etc. The medicated bath method has the effects of cold bath and hot bath, and can make water-soluble medicine be absorbed by skin pores to act on human body.
The medicated bath principle is to exert therapeutic effect on organism by means of water temperature, mechanical stimulation of water and drug action. When the hot liquid medicine is used for fumigation and washing on skin or affected parts, the warm stimulation causes the blood vessel expansion of the skin, can promote the blood and lymph circulation of local and whole body, make metabolism vigorous, improve the nutrition of local tissues and the whole body function, dredge the channels and collaterals and promote the function of regulating the activities of the channels and collaterals. The liquid medicine can stimulate nerve peripheral receptors of the skin, and form new reflex through a nervous system, so that the original pathological reflex connection is destroyed, and the aim of curing diseases is fulfilled.
The Chinese medicinal external washing decoction is widely applied to clinic by doctors nowadays due to the characteristics of simple and convenient preparation, small skin irritation, high mass acceptance and the like. The traditional Chinese medicine preparation has obvious advantages in the field and has particularly obvious effect in the aspect of treating foot fungal infection.
However, at present, mycosis of feet occurs frequently on the epidermis around toes, and patients often show severe itching and are difficult to treat, and for patients suffering from mycotic infection of feet, because of more wrinkles and cracks of foot skin, the foot is only by means of disinfection, the curative effect is poor, strict foot cleaning operation steps are complicated, the patients are difficult to master, the ideal curative effect is difficult to achieve, and in the prior art, the traditional Chinese medicine prescription for mycosis of feet is many, but the curative effect is good and bad, and the illness state is easy to rebound.
Disclosure of Invention
The invention aims to solve the defects in the prior art, and provides foot bath relaxing slow-release powder and a preparation method thereof.
A preparation method of foot bath Shutong slow release powder comprises the following steps:
(1) Mixing Saviae Miltiorrhizae radix, fructus Gardeniae, fructus Piperis Longi, carthami flos, and semen plantaginis, lyophilizing, pulverizing at low temperature, adding dispersant into oil, and stirring for 10-30min to obtain superfine Chinese medicinal powder dispersion;
(2) Adding zein and water-dispersible carbon microspheres into ethanol water solution, adding superfine Chinese medicinal powder dispersion into the solution under stirring, stirring at room temperature for 10-30min, heating to 50-70deg.C, removing ethanol in the system under stirring, evaporating ethanol to remove part of water, solidifying zein, coating on superfine Chinese medicinal powder surface, washing, and vacuum drying to obtain foot bath sustained release powder.
Preferably, in the step (1), the mass ratio of the red sage root, the cape jasmine fruit, the long pepper, the safflower and the plantain seed is 5-15:5-15:5-15:2-8:2-8.
The Saviae Miltiorrhizae radix is dry root and rhizome of Saviae Miltiorrhizae radix of Labiatae. Bitter taste and slightly cold nature. It enters heart and liver meridians. Has effects of promoting blood circulation, regulating menstruation, removing blood stasis, relieving pain, cooling blood, resolving carbuncle, clearing heart fire, relieving restlessness, nourishing blood, and tranquilizing mind. Is mainly used for treating irregular menstruation, amenorrhea and dysmenorrhea, obstruction and accumulation of mass, thoracoabdominal stabbing pain, pyretic arthralgia pain, sore pain, vexation and insomnia; hepatosplenomegaly and angina pectoris.
Gardenia jasminoides ellis, yellow gardenia jasminoides ellis, yellow fruit trees, gardenia jasminoides ellis and red branches are named as gardenia jasminoides ellis. Is dry mature fruit of Gardenia jasminoides Ellis of Rubiaceae of dicotyledon, and its root can also be used as medicine. Bitter in flavor and cold in nature. It enters heart, lung and triple energizer meridians.
The fruit is as follows: purging pathogenic fire, relieving restlessness, clearing heat, promoting urination, cooling blood and removing toxic substances. Can be used for treating febrile vexation, jaundice, dark urine, stranguria with blood, hematemesis, conjunctival congestion, swelling and pain, and pyocutaneous disease due to pathogenic fire; it is indicated for sprain, contusion and pain.
The root of the Chinese herbal medicine comprises the following parts: purging fire and removing toxin, clearing heat and promoting diuresis, cooling blood and removing blood stasis. Can be used for treating infectious hepatitis, traumatic injury, toothache due to pathogenic wind-fire.
Fructus Piperis Longi is used as medicine for drying near-ripe or ripe fruit cluster. Pungent taste and warm nature, and can be used for treating abdominal pain, emesis, diarrhea, coronary heart disease, angina pectoris, nervous headache, toothache, etc. caused by stomach cold. Is an essential herb for easing pain and strengthening stomach.
Safflower is a dried flower of Carthamus tinctorius L of Compositae. Pungent and warm in nature. Has effects in promoting blood circulation, removing blood stasis, and relieving pain. Can be used for treating amenorrhea, dysmenorrhea, lochia, mass, and traumatic injury.
Semen plantaginis is dry mature seed of Plantago asiatica (L.) DC. Ex Fr.) karst of Plantaginaceae. Harvesting the ears when the seeds are ripe in summer and autumn, sun-drying, rubbing out the seeds, and removing impurities. Sweet in flavor and slightly cold in nature. Enter liver, kidney, lung and small intestine meridians. Has effects in clearing away heat, promoting urination, removing dampness, relieving stranguria, improving eyesight, and eliminating phlegm. Can be used for treating swelling and pain of water, stranguria due to heat, summer-heat, diarrhea, conjunctival congestion, swelling and pain, and cough due to phlegm-heat.
Preferably, in the step (1), the mass ratio of the salvia miltiorrhiza to the dispersant to the grease is 5-15:1-2:40-60.
Preferably, in the step (1), the dispersing agent is at least one of polyethylene glycol 200, polyethylene glycol 400 and microcrystalline paraffin.
Preferably, in the step (1), the grease is at least one of maize germ oil, soybean oil and peanut oil.
Preferably, in the step (2), the mass ratio of zein to water-dispersible carbon microspheres to superfine Chinese medicine powder dispersion is 1-5:1-4:80-120.
Preferably, in the step (2), the water-dispersible carbon microsphere is prepared by the following steps: adding polyvinyl alcohol microspheres into water for uniform dispersion, adding silica sol into the mixture under stirring, filtering, washing a filter cake, drying, calcining at 400-500 ℃ for 1-2h under the protection of nitrogen, cooling to room temperature, then soaking the product into sodium hydroxide aqueous solution, washing, and drying to obtain the water-dispersible carbon microspheres.
The silica sol is added into the aqueous dispersion of the polyvinyl alcohol microsphere, the nano silica in the silica sol has active hydroxyl groups, and the surface of the polyvinyl alcohol microsphere contains a large amount of hydroxyl groups, the nano silica is adsorbed on the surface of the polyvinyl alcohol microsphere through electrostatic action and is precipitated, after high-temperature calcination, the polyvinyl alcohol microsphere is decomposed and is deposited on the surface of the silica with good thermal stability to form a carbon microsphere structure, and due to the existence of the silica microsphere, the agglomeration and sintering of adjacent carbon spheres during calcination can be effectively avoided, the adjacent carbon spheres are further soaked in a sodium hydroxide solution, the silica on the surface of the microsphere is removed, and the formed water-dispersible carbon microsphere has good water dispersibility, has a rough surface and can expose more adsorption sites.
Preferably, in the preparation step of the water-dispersible carbon microsphere, the mass ratio of the polyvinyl alcohol microsphere to the silica sol is 1-5:1-3.
Preferably, in the step of preparing the water-dispersible carbon microsphere, the particle size of the polyvinyl alcohol microsphere is 1-10 μm.
Preferably, in the preparation step of the water-dispersible carbon microsphere, the filter cake is washed for 1 to 3 times by hydrochloric acid with the concentration of 0.5 to 1.2mol/L after filtration.
Preferably, in the preparation step of the water-dispersible carbon microsphere, the concentration of the sodium hydroxide aqueous solution is 1-2mol/L.
Preferably, in step (2), the vacuum drying temperature is 40-60 ℃.
Preferably, in the step (2), the mass fraction of the ethanol aqueous solution is 60-80%.
According to the invention, the crushed traditional Chinese medicine powder is added into grease through the dispersing agent, then the grease is added into the ethanol water solution of zein, and the zein is solidified and coated on the crushed traditional Chinese medicine powder to be settled through removing ethanol and part of water, so that the obtained foot bath comfort slow release powder not only can protect and resist oxidation of sensitive active ingredients in the traditional Chinese medicine powder, but also is added into a foot bath barrel, in the foot soaking process, the surface solidified zein can be dissolved by matching with hot water, and the active ingredients can slowly permeate through feet to the channels and collaterals of the whole body, thereby having the functions of dredging and adjusting viscera, and also having excellent treatment effects on foot fungi.
The zein is coated in a microencapsulation way, the dissolution speed in hot water is high, the slow release effect is poor, therefore, the water-dispersible carbon microsphere and zein are further added for compounding, the water-dispersible carbon microsphere has good adsorption performance and rich open mesopores, the zein can fully enter the structure of the water-dispersible carbon microsphere in ethanol water solution due to the unique dissolution performance of the zein, a large amount of hydrophobic amino acid on the surface of the zein can effectively promote the dispersion of the superfine Chinese medicinal powder into the pore structure in the water-dispersible carbon microsphere, the dispersion uniformity among the zein is extremely high, after the zein is solidified at high temperature, the obtained microencapsulation shell has double slow release effect, the zein can slowly release the Chinese medicinal powder in hot water, the slow release effect is good, the slow release continuous effect of the Chinese medicinal powder is long, the external use is 2-3 courses of treatment, the foot fungus infection is recovered to be normal, the medicines are consolidated and are not rebounded, and the effect of thoroughly radically curing the foot fungus is achieved.
The foot bath relaxing slow release powder is prepared by adopting the preparation method of the foot bath relaxing slow release powder.
Drawings
FIG. 1 is a surface potential diagram of the water-dispersible carbon microsphere obtained in example 5.
FIG. 2 is a graph showing the comparison of the instant antibacterial rate, the tested foot-increasing rate and the 12-hour practical antibacterial rate of the foot-bath sultong slow-release powder obtained in the example 5 and the comparative examples 1-2.
Detailed Description
The invention is further illustrated below in connection with specific embodiments.
Example 1
A preparation method of foot bath Shutong slow release powder comprises the following steps:
(1) Uniformly mixing 5kg of red sage root, 5kg of cape jasmine, 5kg of long pepper, 2kg of safflower and 2kg of plantain seed, freeze-drying, adding into a grinding machine, grinding, sieving with a 12-mesh traditional Chinese medicine sieve, adding the medicinal powder into a low-temperature grinder, grinding, adding into 40kg of soybean oil with 1kg of microcrystalline paraffin, and stirring at a speed of 100r/min for 10min to obtain superfine traditional Chinese medicine powder dispersoid;
(2) Adding 1kg of polyvinyl alcohol microspheres with the particle size of 1-10 mu m into 20kg of water, dispersing uniformly, adding 1kg of silica sol into the mixture under stirring, stirring for 20min at the speed of 2000r/min, filtering, washing a filter cake 1 time by adopting hydrochloric acid with the concentration of 0.5mol/L, drying, calcining for 1h at the temperature of 400 ℃ under the protection of nitrogen, cooling to room temperature, then soaking the product into sodium hydroxide aqueous solution with the concentration of 1mol/L, washing until the washing liquid is neutral, and drying to obtain water-dispersed carbon microspheres;
adding 1kg of zein and 1kg of water-dispersible carbon microspheres into 100kg of ethanol aqueous solution with the mass fraction of 60%, adding 80kg of superfine Chinese medicinal powder dispersion into the solution under stirring, stirring at room temperature for 10min at high speed, heating to 50 ℃ under stirring at the stirring speed of 1000r/min, removing ethanol in the system under stirring, evaporating the ethanol to remove part of water, solidifying and separating out zein, coating the zein on the surface of superfine Chinese medicinal powder, washing, and vacuum drying at 40 ℃ to obtain the foot bath sultone slow-release powder.
Example 2
A preparation method of foot bath Shutong slow release powder comprises the following steps:
(1) Uniformly mixing 15kg of red sage root, 15kg of cape jasmine, 15kg of long pepper, 8kg of safflower and 8kg of plantain seed, freeze-drying, adding into a grinding machine, grinding, sieving with a 12-mesh traditional Chinese medicine sieve, adding the medicinal powder into a low-temperature grinder, grinding, adding 2kg of polyethylene glycol 400 into 60kg of peanut oil, and stirring at a speed of 500r/min for 30min to obtain superfine traditional Chinese medicine powder dispersoid;
(2) Adding 5kg of polyvinyl alcohol microspheres with the particle size of 1-10 mu m into 40kg of water, dispersing uniformly, adding 3kg of silica sol into the mixture under stirring, stirring at the speed of 4000r/min for 40min, filtering, washing a filter cake 3 times by adopting hydrochloric acid with the concentration of 1.2mol/L, drying, calcining for 2 hours at the temperature of 500 ℃ under the protection of nitrogen, cooling to room temperature, then soaking the product into sodium hydroxide aqueous solution with the concentration of 2mol/L, washing until the washing liquid is neutral, and drying to obtain water-dispersed carbon microspheres;
adding 5kg of zein and 4kg of water-dispersible carbon microspheres into 200kg of 80% ethanol water solution, adding 120kg of superfine Chinese medicinal powder dispersion into the solution under stirring, stirring at room temperature for 30min at high speed, heating to 70 ℃ under stirring, removing ethanol in the system under stirring, evaporating ethanol to remove part of water, solidifying zein, separating out, coating on the surface of superfine Chinese medicinal powder, washing, and vacuum drying at 60 ℃ to obtain the foot bath sultone sustained release powder.
Example 3
A preparation method of foot bath Shutong slow release powder comprises the following steps:
(1) Uniformly mixing 8kg of red sage root, 12kg of cape jasmine, 7kg of long pepper, 6kg of safflower and 3kg of plantain seed, freeze-drying, adding into a grinding machine, grinding, sieving with a 12-mesh traditional Chinese medicine sieve, adding the medicinal powder into a low-temperature grinder, grinding, adding 1.7kg of polyethylene glycol 200 into 45kg of corn germ oil, and stirring at a speed of 400r/min for 15min to obtain superfine traditional Chinese medicine powder dispersoids;
(2) Adding 4kg of polyvinyl alcohol microspheres with the particle size of 1-10 mu m into 25kg of water, dispersing uniformly, adding 2.5kg of silica sol into the mixture under stirring, stirring at 2500r/min for 35min, filtering, washing a filter cake with hydrochloric acid with the concentration of 0.8mol/L for 2 times, drying, calcining at 470 ℃ for 1.3 hours under the protection of nitrogen, cooling to room temperature, soaking the product into sodium hydroxide aqueous solution with the concentration of 1.8mol/L, washing until the washing liquid is neutral, and drying to obtain water-dispersed carbon microspheres;
adding 2kg of zein and 3kg of water-dispersible carbon microspheres into 140kg of ethanol water solution with the mass fraction of 75%, adding 90kg of superfine Chinese medicinal powder dispersion into the solution under stirring, stirring at room temperature for 25min at a high speed, heating to 65 ℃ at a stirring speed of 2000r/min, removing ethanol in the system under stirring, evaporating the ethanol to remove part of water, solidifying and separating out zein, coating the zein on the surface of superfine Chinese medicinal powder, washing, and vacuum drying at 45 ℃ to obtain the foot bath sultone slow-release powder.
Example 4
A preparation method of foot bath Shutong slow release powder comprises the following steps:
(1) Uniformly mixing 12kg of red sage root, 8kg of cape jasmine, 13kg of long pepper, 4kg of safflower and 7kg of plantain seed, freeze-drying, adding into a grinding machine, grinding, sieving with a 12-mesh traditional Chinese medicine sieve, adding the medicinal powder into a low-temperature grinder, grinding, adding 1.3kg of polyethylene glycol 200 into 55kg of maize germ oil, and stirring at a speed of 200r/min for 25min to obtain superfine traditional Chinese medicine powder dispersoids;
(2) Adding 2kg of polyvinyl alcohol microspheres with the particle size of 1-10 mu m into 35kg of water, dispersing uniformly, adding 1.5kg of silica sol into the mixture under stirring, stirring at 3500r/min for 25min, filtering, washing a filter cake with hydrochloric acid with the concentration of 1mol/L for 2 times, drying, calcining at 430 ℃ under nitrogen protection for 1.7h, cooling to room temperature, soaking the product into sodium hydroxide aqueous solution with the concentration of 1.2mol/L, washing until the washing liquid is neutral, and drying to obtain water-dispersed carbon microspheres;
adding 4kg of zein and 2kg of water-dispersible carbon microspheres into 160kg of ethanol water solution with the mass fraction of 65%, adding 110kg of superfine Chinese medicinal powder dispersion into the solution under stirring, stirring at room temperature for 15min at high speed, heating to 55 ℃ at the stirring speed of 4000r/min, removing ethanol in the system under stirring, evaporating the ethanol to remove part of water, solidifying and separating out zein, coating the zein on the surface of superfine Chinese medicinal powder, washing, and vacuum drying at 55 ℃ to obtain the foot bath sultone slow-release powder.
Example 5
A preparation method of foot bath Shutong slow release powder comprises the following steps:
(1) Uniformly mixing 10kg of red sage root, 10kg of cape jasmine, 10kg of long pepper, 5kg of safflower and 5kg of plantain seed, freeze-drying, adding into a grinding machine, grinding, sieving with a 12-mesh traditional Chinese medicine sieve, adding the medicinal powder into a low-temperature grinder, grinding, adding 1.5kg of polyethylene glycol 200 into 50kg of maize germ oil, and stirring at a speed of 300r/min for 20min to obtain superfine traditional Chinese medicine powder dispersoids;
(2) Adding 3kg of polyvinyl alcohol microspheres with the particle size of 1-10 mu m into 30kg of water, dispersing uniformly, adding 2kg of silica sol into the mixture under stirring, stirring for 30min at a speed of 3000r/min, filtering, washing a filter cake with hydrochloric acid with the concentration of 0.9mol/L for 2 times, drying, calcining for 1.5h at the temperature of 450 ℃ under the protection of nitrogen, cooling to room temperature, soaking the product into sodium hydroxide aqueous solution with the concentration of 1.5mol/L, washing until the washing liquid is neutral, and drying to obtain water-dispersed carbon microspheres;
adding 3kg of zein and 2.5kg of water-dispersible carbon microspheres into 150kg of ethanol aqueous solution with the mass fraction of 70%, adding 100kg of superfine Chinese medicine powder dispersion into the solution under stirring, stirring at room temperature for 20min at high speed, heating to 60 ℃ under stirring at a stirring speed of 3000r/min, removing ethanol in the system under stirring, evaporating the ethanol to remove part of water, solidifying and separating out zein, coating the zein on the surface of superfine Chinese medicine powder, washing, and drying at 50 ℃ under vacuum to obtain the foot bath sultone slow-release powder.
The surface potential of the water-dispersible carbon microsphere obtained in example 5 was measured and as shown in fig. 1, in the environment of ph=7, the surface potential of the water-dispersible carbon microsphere obtained in example 5 could reach-39.78 mV, and not only the surface was negatively charged, but also the water-dispersible carbon microsphere could be stably dispersed in an aqueous solution.
Comparative example 1
A preparation method of foot bath Shutong slow release powder comprises the following steps:
(1) Uniformly mixing 10kg of red sage root, 10kg of cape jasmine, 10kg of long pepper, 5kg of safflower and 5kg of plantain seed, freeze-drying, adding into a grinding machine, grinding, sieving with a 12-mesh traditional Chinese medicine sieve, adding the medicinal powder into a low-temperature grinder, grinding, adding 1.5kg of polyethylene glycol 200 into 50kg of maize germ oil, and stirring at a speed of 300r/min for 20min to obtain superfine traditional Chinese medicine powder dispersoids;
(2) Adding 3kg of zein into 150kg of ethanol water solution with the mass fraction of 70%, adding 100kg of superfine Chinese medicinal powder dispersion into the solution under stirring, stirring at room temperature for 20min at high speed, heating to 60 ℃ under stirring, removing ethanol in the system under stirring, evaporating the ethanol to remove part of water, solidifying and separating out zein, coating the zein on the surface of the superfine Chinese medicinal powder, washing, and drying at 50 ℃ under vacuum to obtain the foot bath sultone slow-release powder.
Comparative example 2
A preparation method of foot bath Shutong slow release powder comprises the following steps:
(1) Uniformly mixing 10kg of red sage root, 10kg of cape jasmine, 10kg of long pepper, 5kg of safflower and 5kg of plantain seed, freeze-drying, adding into a grinding machine, grinding, sieving with a 12-mesh traditional Chinese medicine sieve, adding the medicinal powder into a low-temperature grinder, grinding, adding 1.5kg of polyethylene glycol 200 into 50kg of maize germ oil, and stirring at a speed of 300r/min for 20min to obtain superfine traditional Chinese medicine powder dispersoids;
(2) Drying polyvinyl alcohol microspheres with the particle size of 1-10 mu m, calcining for 1.5 hours at the temperature of 450 ℃ under the protection of nitrogen, cooling to room temperature, then soaking the product into 1.5mol/L sodium hydroxide aqueous solution, washing until washing liquor is neutral, and drying to obtain pretreated polyvinyl alcohol microspheres;
adding 3kg of zein and 2.5kg of pretreated polyvinyl alcohol microspheres into 150kg of ethanol aqueous solution with the mass fraction of 70%, adding 100kg of superfine Chinese medicine powder dispersoid into the solution under stirring, stirring at room temperature for 20min at high speed, heating to 60 ℃ under stirring at a stirring speed of 3000r/min, removing ethanol in the system under stirring, evaporating the ethanol to remove part of water, solidifying and separating out zein, coating the zein on the surface of the superfine Chinese medicine powder, washing, and drying at 50 ℃ under vacuum to obtain the foot bath sultone slow-release powder.
The corresponding instrument was wiped with 75% alcohol and irradiated with ultraviolet light for 2 hours. Taking a disposable sterile plastic bag to be sleeved in a foot bath basin, respectively adding the foot bath soft-release powder obtained in the example 5 and the comparative examples 1-2 into the foot bath basin, adding 1L of sterile warm water (50 ℃), standing until the water temperature is 40+/-1 ℃, immersing the test foot in the medicinal liquid, so that the sampling part is completely immersed in the medicinal liquid, and soaking and washing for 20 minutes. The subject properly moves the foot and toe joints for 30 seconds every 5 minutes during the soak. And finally, wiping the skin with a sterile dressing, and sleeving a sterile foot sleeve by an operator according to a sterile principle after sampling.
The operator takes a cotton swab containing the sampling liquid, holds the cap end, and smears the swab 2 times at the webbings (each webbings has an area of about 2 cm) 2 Totaling 16cm 2 ) Taking sterile standard plate (3×4 cm) and respectively placing at instep and plantar metatarsal bones, respectively, and repeatedly rubbing with swab cotton head for 2 times, about 48cm 2 The subjects were then instructed to apply the ankle dorsal extension to the posterior lateral skin fold of the heel (around the near achilles tendon stop) for 2 passes over an area of about 6cm 2 In the process of smearing, the swab is continuously rotated to ensure that the cotton swab head is fully contacted with the skin, and the total sampling area is about 70cm 2 . The alcohol burner is inserted into the swab for sealing after burning the nozzle, and the code is sent to inspection.
1. Sensitization evaluation
After foot bath, the patient was asked for skin feel, and the local skin reaction was observed for 48 hours, and the sensitization response rate was calculated. The sensitization rate of example 5 was 0, the sensitization rate of comparative example 1 was 10%, and the sensitization rate of comparative example 2 was 3.33%.
The applicant believes that: the reason is that the comparative example 1 adopts zein to carry out microencapsulation coating on the traditional Chinese medicine powder, the dissolution speed in hot water is high, the slow release effect is poor, the concentration of the superfine traditional Chinese medicine powder dispersoid in water is rapidly increased to the highest, and the superfine traditional Chinese medicine powder dispersoid contains partial sensitization components, so that skin allergy of sensitive people is caused. The slow release powder of the foot bath sultong obtained in the comparative example 2 adopts the pretreated polyvinyl alcohol microsphere to form the slow release effect on the superfine Chinese medicine powder dispersion, so that the sensitization response rate of the slow release powder of the foot bath sultong obtained in the comparative example 2 is lower than that of the slow release powder of the foot bath sultong obtained in the comparative example 1. In the preparation process of the embodiment 5, the water-dispersible carbon microspheres are adopted as slow release components, so that part of the traditional Chinese medicine extract is slowly released, the initial concentration of the foot bath sultong slow release powder added into water is inferior to that of the comparative example, and the allergic reaction of a subject is avoided.
2. Immediate bacteriostasis rate
And calculating the instant bacteriostasis rate according to the data before and after soaking and washing of each group, and reflecting the instant bacteriostasis effect.
Immediate antibacterial ratio = (number of colonies before soaking-number of colonies after soaking)/(number of colonies before soaking ×100%)
3. Test foot enrichment rate
According to the colony number after soaking and washing and the colony number after soaking and washing for 12 hours, the bacterial increment rate of the tested foot is calculated, and the delay antibacterial effect is reflected.
Test foot enrichment ratio= (number of colonies after soaking and washing 12 h-number of colonies after soaking and washing)/(number of colonies after soaking and washing×100%)
4. 12h actual antibacterial rate
According to the colony number of each group of the bacteria after soaking and washing and the colony number before soaking and washing, calculating the actual antibacterial rate of 12 hours, and reflecting the antibacterial effect of the time interval of the medication.
12h actual antibacterial ratio= (number of colonies before washing by bubbling-number of colonies after washing by bubbling)/(number of colonies before washing by bubbling ×100%)
The instant antibacterial rate, the tested foot bacterial increasing rate and the 12-hour practical antibacterial rate are shown in figure 2, the instant antibacterial rate of the foot bath Shutong slow release powder obtained in the example 5 is slightly lower than that of the comparative example, but the tested foot bacterial increasing rate and the 12-hour practical antibacterial rate are far better than those of the comparative example. The applicant believes that: the preparation process of the embodiment 5 adopts the water-dispersed carbon microspheres as a slow release component, so that part of traditional Chinese medicine extract is slowly released, the initial concentration of the foot bath sultong slow release powder added into water is inferior to that of the comparative example, but along with the extension of the soaking and washing process, the water-dispersed carbon microspheres containing superfine traditional Chinese medicine powder dispersion can be partially adhered to feet, thereby being capable of slowly releasing for a long time, improving the antibacterial effect, reducing the tested foot enrichment rate and improving the 12-hour practical antibacterial rate.
The foregoing is only a preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art, who is within the scope of the present invention, should make equivalent substitutions or modifications according to the technical scheme of the present invention and the inventive concept thereof, and should be covered by the scope of the present invention.
Claims (6)
1. The preparation method of the foot bath Shutong slow release powder is characterized by comprising the following steps:
(1) Mixing Saviae Miltiorrhizae radix, fructus Gardeniae, fructus Piperis Longi, carthami flos, and semen plantaginis, lyophilizing, pulverizing at low temperature, adding dispersant into oil, and stirring for 10-30min to obtain superfine Chinese medicinal powder dispersion;
in the step (1), the mass ratio of the red sage root, the cape jasmine, the long pepper, the safflower and the plantain seed is 5-15:5-15:5-15:2-8:2-8;
in the step (1), the mass ratio of the salvia miltiorrhiza to the dispersant to the grease is 5-15:1-2:40-60;
(2) Adding zein and water-dispersible carbon microspheres into ethanol water solution, adding superfine Chinese medicinal powder dispersion into the solution under stirring, stirring at room temperature for 10-30min, heating to 50-70deg.C, removing ethanol in the system under stirring, washing, and vacuum drying to obtain foot bath sustained release powder;
in the step (2), the mass ratio of zein to water-dispersible carbon microspheres to superfine Chinese medicinal powder dispersion is 1-5:1-4:80-120 parts;
in the step (2), the water-dispersible carbon microsphere is prepared by the following steps: adding polyvinyl alcohol microspheres into water for uniform dispersion, adding silica sol into the mixture under stirring, filtering, washing a filter cake, drying, calcining at 400-500 ℃ for 1-2h under the protection of nitrogen, cooling to room temperature, then soaking the product into sodium hydroxide aqueous solution, washing, and drying to obtain the water-dispersible carbon microspheres.
2. The method for preparing the slow release powder for foot bath according to claim 1, wherein in the step (1), the dispersing agent is selected from polyethylene glycol 200, polyethylene glycol 400 and microcrystalline paraffin.
3. The method for preparing the slow release powder for foot bath and comfort according to claim 1, wherein in the step (1), the grease is selected from corn germ oil, soybean oil and peanut oil.
4. The method for preparing the slow release powder for foot bath according to claim 1, wherein in the step (2), the vacuum drying temperature is 40-60 ℃.
5. The method for preparing the slow release powder for foot bath and comfort according to claim 1, wherein in the step (2), the mass fraction of the ethanol aqueous solution is 60-80%.
6. A foot bath Shutong slow release powder, which is characterized by being prepared by adopting the preparation method of the foot bath Shutong slow release powder as claimed in any one of claims 1 to 5.
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| KR20150060212A (en) * | 2013-11-26 | 2015-06-03 | 김구환 | The method of manufacturing foot bath additives using traditional Korean medicine |
| KR20210100986A (en) * | 2020-02-07 | 2021-08-18 | 동국제약 주식회사 | Method for preparing microspheres with high density and sustained release |
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| CN104397828B (en) * | 2014-11-19 | 2017-05-10 | 渤海大学 | Preparation method of modified zein composite slow-release antibacterial liquid membrane |
| CN107050154A (en) * | 2017-04-18 | 2017-08-18 | 奥乌力吉 | It is a kind of to treat outer bath anaesthetic of gout and preparation method thereof |
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| KR20210100986A (en) * | 2020-02-07 | 2021-08-18 | 동국제약 주식회사 | Method for preparing microspheres with high density and sustained release |
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