CN100998774A - External use medicine liquid for treating alopecia - Google Patents

External use medicine liquid for treating alopecia Download PDF

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Publication number
CN100998774A
CN100998774A CNA2007100538512A CN200710053851A CN100998774A CN 100998774 A CN100998774 A CN 100998774A CN A2007100538512 A CNA2007100538512 A CN A2007100538512A CN 200710053851 A CN200710053851 A CN 200710053851A CN 100998774 A CN100998774 A CN 100998774A
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rhizoma
alopecia
radix
poria
polygoni multiflori
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CN100534501C (en
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付小珍
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Abstract

An exterior-applied Chinese medicine in the form of liquid for treating alopecia is prepared from 12 Chinese-medicinal materials including fleece flower root, black sesame, tuckahoe, saffron, etc through steaming, drying in the air, superfine pulverizing, immersing in grains liquor, and filtering.

Description

A kind of external medicinal liquid for the treatment of alopecia
One, technical field
The present invention relates to field of medicaments, particularly a kind of external medicinal liquid for the treatment of alopecia.
Two, background technology
Alopecia is a kind of common frdquently encountered disease, have a strong impact on patient's physical and mental health, particularly aspect spiritual, bring very big misery and worried, for this reason, people are concerned about how effectively treating alopecia very much, and the corresponding medicine that many treatment alopecias also occurred, but because the change of people's living environment and the quickening of rhythm of life, particularly a large amount of automobiles along with industrialized fast development and urban transportation are used, tackle natural environment mutually and also caused artificial environmental pollution, add work, study, have a rest, unreasonable domination on the diet nutritional, present various forms of alopecias are on the rise, and this has to cause the attention of people's height, and wish to have new drug to occur, timely and effectively alopecia is treated, it is painful and worried to reduce people, builds a Harmonious Society.
Three, summary of the invention
At above-mentioned situation; the present invention's purpose just provides a kind of external medicinal liquid for the treatment of alopecia; can effectively solve the treatment problem of alopecia, the technical scheme of its solution is that the traditional Chinese medical science is thought; alopecia is to be obstructed because of its blood circulation; insufficiency of vital energy and blood, normally hair growth promoting of hair follicle is due to human body can not normally be taken care of hair; its treatment should be according to Chinese medicine and pharmacy treating both the principal and secondary aspects of a disease principle; with blood circulation promoting and blood stasis dispelling; expanding the Tibetan household slave sends out; mend lean blood; crow palpus hair color; debris removal is antipruritic; the control alopecia promotes that hair growth is basic, utilization Chinese materia medica principle; adopt Radix Polygoni Multiflori; Semen Sesami Nigrum; Poria; Stigma Croci; Rhizoma Chuanxiong; the Rhizoma Pinelliae; Radix Angelicae Sinensis; Radix Ginseng; Cornu Cervi Pantotrichum; Rhizoma Gastrodiae; Pupa bombycis and brown iron oxide and grain wine are made; wherein earlier 12 flavor Chinese medicine water steam are steamed, dry micronizing again, add grain wine and soak; getting yeast for brewing rice wine liquid after the filtration gets final product; prescription science of the present invention, simple, easily produce; easily use; remarkably productive, hair growth promoting is fast, and cost is low; economic and social benefit is huge, is the creative contribution to Chinese medicine and pharmacy.
Four, the specific embodiment
Below in conjunction with practical situation the specific embodiment of the present invention is elaborated.
Provide by technical scheme, the present invention adopts Radix Polygoni Multiflori 17-20g, Semen Sesami Nigrum 13-16g, Poria 13-16g, Stigma Croci 11-13g, Rhizoma Chuanxiong 12-14g, Rhizoma Pinelliae 11-13g, Radix Angelicae Sinensis 8-10g, Radix Ginseng 5-7g, Cornu Cervi Pantotrichum 3-5g, Rhizoma Gastrodiae 6-8g, Pupa bombycis 10-12g and brown iron oxide 14-18g and grain wine 450-600ml make, Radix Polygoni Multiflori wherein, Semen Sesami Nigrum, Poria, Stigma Croci, Rhizoma Chuanxiong, the Rhizoma Pinelliae, Radix Angelicae Sinensis, Radix Ginseng, Cornu Cervi Pantotrichum, Rhizoma Gastrodiae, Pupa bombycis and brown iron oxide steam 10-20 minute with steam earlier, dry the back micronizing, add the grain wine sealing again, soaked 5-10 days down at 20-28 ℃, filter to such an extent that yeast for brewing rice wine liquid gets final product.
The present invention preferably adopts Radix Polygoni Multiflori 18g aborning, Semen Sesami Nigrum 14g, Poria 14g, Stigma Croci 12g, Rhizoma Chuanxiong 13g, Rhizoma Pinelliae 12g, Radix Angelicae Sinensis 9g, Radix Ginseng 6g, Cornu Cervi Pantotrichum 4g, Rhizoma Gastrodiae 7g, the mass concentration of Pupa bombycis 11g and brown iron oxide 16g and 500ml is that 65% grain wine is made, Radix Polygoni Multiflori wherein, Semen Sesami Nigrum, Poria, Stigma Croci, Rhizoma Chuanxiong, the Rhizoma Pinelliae, Radix Angelicae Sinensis, Radix Ginseng, Cornu Cervi Pantotrichum, Rhizoma Gastrodiae, Pupa bombycis and brown iron oxide steam 15 minutes with steam earlier, dry the back micronizing and cross the above sieve of 120 orders, adding mass concentration again and be 65% grain wine is sealed in the medicinal cupping, soaked 7 days down at 25 ℃, get yeast for brewing rice wine liquid with filtered through gauze, be sub-packed in the bottle and can use.
In said medicine, wherein:
Radix Polygoni Multiflori: the tuber for Polygonaceae liana Radix Polygoni Multiflori, remove stem and leaf, to clean, section is dried or the low baking temperature oven dry, or adds Semen sojae atricolor and steam and shine quality and become Radix Polygoni Multiflori Preparata, adopts Semen sojae atricolor to steam the Radix Polygoni Multiflori Preparata that shines among the present invention, has invigorating the liver and kidney, beneficial marrow, effect that black beard and hair is black;
Semen Sesami Nigrum: be the seed of Pedaliaceae plant Semen Sesami, it is dry to have an invigorating the liver and kidney, benefiting essence-blood, intestine moistening, is used for dizziness and blurred vision, Hiccough and deaf, early whitening of beard and hair, post disease alopecia etc.;
Poria: be the truffle of Polyporaceae parasitic plant Poria fungus, remove its earth, dry, section has the function of promoting diuresis to eliminate damp pathogen, spleen invigorating invigorating middle warmer, mind tranquilizing and the heart calming;
Stigma Croci: get over year tubular flower of this plant of SHENGCAO Flos Carthami for Compositae, all there is product Chinese many provinces and regions, and the medicinal Flos Carthami in Tibet claims Stigma Croci, dries after the harvesting, and decontamination is gone into the heart, Liver Channel, has the function of promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing;
Rhizoma Chuanxiong: be Umbelliferae herbaceos perennial Rhizoma Chuanxiong rhizome, dig and to remove earth after adopting, dry or dry, section, have invigorate blood circulation, the function of circulation of qi promoting, wind-expelling pain-stopping;
The Rhizoma Pinelliae: be the dried root of the aroid Rhizoma Pinelliae, remove earth after adopting, put into cylinder, add Alumen and handle, remove crust, the reuse fresh ginger juice is mixed thoroughly to dry and is made Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), has dampness disease, stopping nausea and vomiting by lowering the adverse flow of QI function;
Radix Angelicae Sinensis: be the root of Umbelliferae herbaceos perennial Radix Angelicae Sinensis, remove earth after excavating, smoke-dried beancurd, section, wine is fried, and has the function of benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation;
Radix Ginseng: be the dry root of Araliaceae Radix Ginseng, remove earth after adopting control, dry, the time spent section has strongly invigorating primordial QI, and spleen reinforcing is promoted the production of body fluid and the function of the mind calming and mentality promoting;
Cornu Cervi Pantotrichum: be the still unossified young horn of stag, boil processing with boiling water in the back down from the stag saw, natural air drying is scraped remove floss, coats wine, sets fire and goes up soft section of baking or pulverize, has warming the stomach, the kidney invigorating arteries and veins, and spermatogenesis is mended the function of marrow;
Rhizoma Gastrodiae: for the tuber of orchid Rhizoma Gastrodiae, excavate afterwash, remove rough bark, section is dried, and has the wind dispelling spasmolytic, ends the dizzy function of the head;
Pupa bombycis: be the worm pupa dry product of Bombycidae insecticide silkworm, kidney invigorating and YANG supporting, arresting seminal emission, hemostasis, removing toxic substances and promoting subsidence of swelling;
Brown iron oxide (Fe 2O 3): claiming pig iron rust again, is a kind of redness or black amorphous powder, has the function of polishing, catalysis, as polish, catalyst, coordinates component, promotes the active component of medicine to play one's part to the full, and has physics and chemical double effects etc.;
Grain wine: be the wine made from Sorghum vulgare Pers. or other grain (corn, Fructus Hordei Vulgaris, rice), main component is ethanol (CH 3CH 2OH), can sterilize, invigorate blood circulation, blood vessel dilating is again good solvent, and fully wash rice goes out the active component of Chinese medicine, improves curative effect, is effective to medication preparation.The white grain fermented wine of the 50-65 degree of selling on the market among the present invention all can adopt, and is convenient, aboundresources.
By the function of above component as can be seen, its compatibility is supported each other on function, is effectively played a role, nourishing the liver and kidney, the spermatogenesis that nourishes blood, blood circulation promoting and blood stasis dispelling, dispelling toxicity, detoxicating, beauty care, the removing heat from blood hair growth promoting, thus realize treatment to alopecia, be effective to diseases such as alopecia areata, speckle are taken off, taken off entirely, alopecia totalis, seborrheic alopecia, nervous alopecia, wound alopecia, its clinical data also fully proves the effect that it is unique, and interrelated data is as follows:
(1) standard of selection case
Everyly have that speckle takes off, alopecia areata, take off alopecia totalis, seborrheic alopecia, nervous alopecia, traumatic alopecia, unknown cause entirely alopecia, only a few because the alopecia that collapse, breast feeding in puerperal anemia cause behind the high pressure disorders of blood of alopecia, puerperal and antenatal a variety of causes that anemia causes, all in the standard of selecting treatment.
(2) diagnostic criteria
Standard by national regulation is diagnosed.
1, speckle takes off: be to meet " mood " internal injury again because deficiency of the kidney blood is given birth to wind, or overwork (physical work, mental work), or diseases caused by exogenous pathogenic factor, due to " six climate exopathogens " ailment said due to cold or exposure invasion and attack, skin nutrition out of balance, take off as fruit spot and can not get treatment in time and development is helped taken off, become alopecia totalis, few person's some months, many persons two, three years, and also whole human body whole persons of coming off such as hair, eye, eyebrow, beard, fine hair occur and takes off for speckle.
2, seborrheic alopecia: pilosity is born in the male, the women is quite a few to be seen, most of people be because overwork, endocrine disturbance, scalp portion exudate increase, body intracellular metabolite system disorders, the Inheritance history is arranged, add the strange land of going out, being not acclimatized etc., this state of an illness is slow, belongs to the obstinate alopecia that not obvious reason causes.
3, take off entirely: geneogenous alopecia and acquired disposition alopecia are arranged, give birth to the alopecia that skin ulcer causes as head, all affected part hairs are not all sloughed the person for taking off entirely.
4, nervous alopecia: pathogenic factor is a deficiency of the kidney, and the patient is often itched, is worried to excess, sleeps bad with dizziness, headache, scalp before alopecia, and caused thus alopecia is diagnosed as nervous alopecia.
(3) efficacy assessment standard
Pressing national regulation carries out
Outstanding (healing): transference cure, hair grows, but normal development, and keep.
Well (effectively): symptom has improvement, and the part hair grows, and the trend that develops toward the good aspect is arranged.
Relatively poor (invalid): symptom does not have improvement substantially, even further degradating trend is arranged, or do not have obvious therapeutic effect.
(4) therapeutic scheme
Smear outside affected part with medicinal liquid of the present invention, every day early, evening each once, 20-30 days is a course of treatment, alopecia history 2 years is arranged with interior person, needs 1-2 the course of treatment, the interior person of course of disease 3-5,3 courses of treatment, the course of disease is the person more than 8 years, 3-6 the course of treatment.
(5) statistical procedures situation
Through to hair loss patient 986 people statistics, male's 616 examples wherein, women's 370 examples, oldest 68 years old, minimum 16 years old, its therapeutic effect was divided into outstanding, good, relatively poor three groups, and by the therapeutic scheme treatment of aforementioned (four), the result is as follows:
Alopecia kind therapeutic effect catalog
The alopecia kind Sex Number Outstanding Percentage ratio Well Percentage ratio Relatively poor Percentage ratio
Speckle takes off The man 169 128 75.7% 35 20.7% 6 3.6%
The woman 98 74 75.5% 21 21.4% 3 3.1%
Take off entirely The man 142 99 69.7% 29 20.4% 14 9.9%
The woman 83 55 66% 20 24% 8 10%
Seborrhea The man 126 82 65% 30 24% 14 11%
The woman 68 46 67.5% 14 20% 8 12.5%
Nerve The man 98 57 58% 25 29% 16 16%
The woman 75 40 54% 20 26% 15 20%
Traumatic The man 68 54 79% 9 13% 5 8%
The woman 59 44 74.6% 8 13.6% 7 11.8%
As can be seen from the above table, medicinal liquid of the present invention all has significant curative effect to treating various types of alopecias, and curative effect is minimum also 80%, and up to having more than 96%, existing treatment alopecia medicine can't be compared.
Six, toxicity test
Safe in utilization in order to guarantee, the spy has done zoopery (by the animal experiment of family's regulation) to it:
Test method: 18-24h before the test, be equipped with 4 (being numbered 1,2,3,4) unhairing districts in Cavia porcellus spinal column both sides, every unhairing area is about 2cm * 2cm, and 1,3 are positioned at the left side, and 2,4 are positioned at the right side.During experiment, animal is fixed on the special plank, to be tried the about 0.2g of thing is applied in the unhairing district 1,2,3,4 be not coated with and tried thing, be coated with and tried thing and after 30 minutes 1,3 districts are covered with aluminium-foil paper, adhesive tape is fixed, and 2,4 districts are shone with the UVA line source, irradiation finishes the back and observes dermoreaction respectively at 1h, 24h, 48h and 72h, judges every animal skin reaction scoring according to " skin Phototoxicity experiment " table 2 in " cosmetics health standard ".
The positive controls experimental procedure only is coated with positive thing 0.005%5-MOP with trying the thing group in the unhairing district.
Result of the test is as follows:
Tried thing skin light poison result of the test
Number of animals Sex Body weight (g) The dermoreaction integration
1h 24h 48h 72h
1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4
1 245.1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 238.0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
3 290.4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
4 296.9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
5 318.2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
6 315.9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Conclusion: according to above result, estimate, do not see that animal subject has the skin phototoxic reaction by the skin irritation response strength.
Seven, conclusion
Can clearly show by above situation, the present invention is the good medicine of the treatment baldness of no side effects, clinical meaning is outstanding, can be effective to all types of baldness, prescription science of the present invention, cost is low, the effective percentage height, easily Chinese medicine and ferrum oxide (Fe have been adopted in production and popularization and application, particularly the present invention 2O 3) and grain wine three bonded prescriptions, both guaranteed the physical action of medicine, impel the generation chemical action again, effectively enhance metabolism, the generation of new cell, thereby promotion hair growth, beard and hair is pitch-black, is that other drug can't be compared, of the present invention succeeding in developing, for the treatment alopecia provides good condition, bring benefit to the mankind.

Claims (2)

1, a kind of external medicinal liquid for the treatment of alopecia, it is characterized in that, be to adopt Radix Polygoni Multiflori 17-20g, Semen Sesami Nigrum 13-16g, Poria 13-16g, Stigma Croci 11-13g, Rhizoma Chuanxiong 12-14g, Rhizoma Pinelliae 11-13g, Radix Angelicae Sinensis 8-10g, Radix Ginseng 5-7g, Cornu Cervi Pantotrichum 3-5g, Rhizoma Gastrodiae 6-8g, Pupa bombycis 10-12g and brown iron oxide 14-18g and grain wine 450-600ml make, Radix Polygoni Multiflori wherein, Semen Sesami Nigrum, Poria, Stigma Croci, Rhizoma Chuanxiong, the Rhizoma Pinelliae, Radix Angelicae Sinensis, Radix Ginseng, Cornu Cervi Pantotrichum, Rhizoma Gastrodiae, Pupa bombycis and brown iron oxide steam 10-20 minute with steam earlier, dry the back micronizing, add the grain wine sealing again, soaked 5-10 days down at 20-28 ℃, filter yeast for brewing rice wine liquid.
2, a kind of external medicinal liquid for the treatment of alopecia according to claim 1, it is characterized in that, be to adopt Radix Polygoni Multiflori 18g, Semen Sesami Nigrum 14g, Poria 14g, Stigma Croci 12g, Rhizoma Chuanxiong 13g, Rhizoma Pinelliae 12g, Radix Angelicae Sinensis 9g, Radix Ginseng 6g, Cornu Cervi Pantotrichum 4g, Rhizoma Gastrodiae 7g, the mass concentration of Pupa bombycis 11g and brown iron oxide 16g and 500ml is that 65% grain wine is made, Radix Polygoni Multiflori wherein, Semen Sesami Nigrum, Poria, Stigma Croci, Rhizoma Chuanxiong, the Rhizoma Pinelliae, Radix Angelicae Sinensis, Radix Ginseng, Cornu Cervi Pantotrichum, Rhizoma Gastrodiae, Pupa bombycis and brown iron oxide steam 15 minutes with steam earlier, dry the back micronizing and cross the above sieve of 120 orders, adding mass concentration again and be 65% grain wine is sealed in the medicinal cupping, soaked 7 days down at 25 ℃, get yeast for brewing rice wine liquid with filtered through gauze.
CNB2007100538512A 2007-01-16 2007-01-16 External use medicine liquid for treating alopecia Expired - Fee Related CN100534501C (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101574480B (en) * 2009-06-16 2010-12-29 罗家恒 Chinese medicinal preparation for treating alopecia and preparation method thereof
CN104225269A (en) * 2013-06-22 2014-12-24 肖慈勇 Hair regrowth liniment and preparation method thereof
CN111110585A (en) * 2019-12-31 2020-05-08 武汉华肽生物科技有限公司 Hair-blacking composition based on gene recombinant protein Tat-hMsrA and application thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101574480B (en) * 2009-06-16 2010-12-29 罗家恒 Chinese medicinal preparation for treating alopecia and preparation method thereof
CN104225269A (en) * 2013-06-22 2014-12-24 肖慈勇 Hair regrowth liniment and preparation method thereof
CN111110585A (en) * 2019-12-31 2020-05-08 武汉华肽生物科技有限公司 Hair-blacking composition based on gene recombinant protein Tat-hMsrA and application thereof

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Publication number Publication date
CN100534501C (en) 2009-09-02

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