CN115137787A - Intestine moistening and bowel relaxing aloe composition, aloe capsule and preparation method thereof - Google Patents
Intestine moistening and bowel relaxing aloe composition, aloe capsule and preparation method thereof Download PDFInfo
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Abstract
The application relates to the field of food with the effects of relaxing bowel, and particularly discloses an aloe composition and an aloe capsule for relaxing bowel and a preparation method thereof, wherein the aloe composition is prepared from the following raw materials in parts by weight: 180-220 parts of aloe whole leaf dry powder, 30-40 parts of fructus cannabis extract, 30-40 parts of folium sennae extract, 15-20 parts of angelica sinensis extract and 100-110 parts of polydextrose. The aloe capsule comprises a core particle and a shell, the core particle comprising an aloe composition; the preparation method comprises the following steps: mixing Aloe whole leaf dry powder, fructus Cannabis extract, folium Psidii Guajavae extract, radix Angelicae sinensis extract and polydextrose, and making into raw material mixture; filling the raw material mixture into capsule shell to obtain primary aloe capsule; polishing the primary aloe capsule to obtain the aloe capsule product. The aloe product has the characteristics that the aloe content of the obtained aloe product is lower, and meanwhile, the excellent effect of relaxing bowel is achieved.
Description
Technical Field
The application relates to the technical field of food with effects of relaxing bowel, in particular to an aloe composition and an aloe capsule for relaxing bowel and a preparation method thereof.
Background
Constipation is a common symptom of the digestive system, which is caused by the fact that feces stay in the colon for too long time, the moisture content is reduced, the feces are dry and hard, the quantity is small, and the feces are not easy to be discharged, so that the constipation is a very common clinical symptom, the incidence rate of the constipation occurs in people of different ages, particularly the elderly is higher, and the age of patients with constipation is gradually growing to be younger. Long-term constipation can bring certain harm to health, and as waste cannot be discharged out of the body in time, protein putrefaction can cause toxic reaction after being absorbed into the body from intestinal tracts, and symptoms such as inappetence, abdominal distension, fatigue and the like are generated, thus being unfavorable for health.
The use of different aloe preparations for treating constipation is accepted by patients. For example, the chinese patent with application publication number CN107801997a discloses an aloe capsule with bowel relaxing and bowel relaxing functions and a preparation method thereof, wherein the active ingredient of the aloe capsule is aloe dry powder. Preferably, the aloe dry powder is aloe vera whole leaf dry powder.
Although aloe can relieve constipation, intestinal pseudo-black skin disease can be caused by long-term taking of aloe, and colonic black stool disease is also reported to be caused by long-term taking of aloe and has adverse effects on human bodies, so that the dosage of aloe is limited afterwards, and in order to achieve effective bowel relaxing effect, a new aloe composition needs to be developed.
Disclosure of Invention
In order to achieve excellent bowel relaxing effect while the content of aloe is lower, the application provides a bowel relaxing aloe composition, an aloe capsule and a preparation method thereof.
In a first aspect, the application provides an aloe composition for relaxing bowel, which adopts the following technical scheme:
the aloe composition for relaxing bowel is prepared from the following raw materials in parts by weight:
180-220 parts of aloe whole leaf dry powder, 30-40 parts of fructus cannabis extract, 30-40 parts of folium sennae extract, 15-20 parts of angelica sinensis extract and 100-110 parts of polydextrose.
By adopting the technical scheme, the aloe composition takes aloe whole-leaf dry powder, folium sennae extract and polydextrose as main raw materials, the aloe whole-leaf dry powder is obtained by extracting fresh leaves of aloe vera, and contains active ingredients with various effects on human bodies, such as barbaloin, aloe polysaccharide and the like. The aloin is hydroxy anthraquinone derivative, and when the aloin enters the intestinal tract, under the action of bile, anthraquinone derivatives such as aloe-emodin glycoside and isoaloe-emodin glycoside contained in the aloin derivative release emodin and the like in the intestinal tract, stimulate the large intestine to produce purgation effect, and play a role in loosening the bowel to relieve constipation;
the fructus cannabis extract can stimulate the mucosa of the gastrointestinal tract, and the gastrointestinal tract can secrete a large amount of gastric juice after being stimulated, so that the peristalsis is accelerated, and the effect of reducing the water absorption of the large intestine and then the diarrhea is achieved; the senna leaf is a dianthracene compound comprising sennoside A-sennoside F, the sennoside is absorbed by small intestine and then is converted into rhein anthrone by microorganisms, and the sennoside has beneficial effect on stimulating colon activity, can accelerate intestinal peristalsis, improve digestion, increase fluid secretion, and inhibit absorption of water and electrolyte by large intestine, so that volume and pressure of intestinal contents are increased, and the senna leaf can stimulate push-type contraction movement of colon and is beneficial to discharge of substances in vivo. In addition, the folium sennae also has antibacterial effect on microorganisms such as Escherichia coli, shigella dysenteriae and Proteus.
The aloe whole leaf dry powder, the fructus cannabis extract and the folium sennae extract are matched with each other, the aloe whole leaf dry powder and the folium sennae extract are particularly used as the main materials to play a role in relaxing bowel, and particularly compared with a traditional aloe capsule, the fructus cannabis extract and the folium sennae extract replace partial barbaloin functional components, so that the aloe capsule can play a good role in relaxing bowel, even compared with a single aloe component, the effect of relaxing bowel is better, the adverse effect of overlarge aloe content on a human body is greatly reduced, and the aloe composition can play a better role in relaxing bowel under the condition of containing a lower aloe component.
In addition, the fructus cannabis extract and the senna leaf extract have strong effects and have certain irritation to a human body, so the angelica sinensis extract and the polydextrose are added, the angelica sinensis is mild, and have a certain effect of relaxing bowel, and the polydextrose serving as water-soluble dietary fiber cannot be degraded by intestinal digestive enzymes and can only be partially fermented by intestinal microorganisms to generate short-chain fatty acids to stimulate intestinal peristalsis and increase the water retention of feces, so that the effect of preventing constipation is achieved.
Finally, the aloe composition taking the aloe whole leaf dry powder, the senna leaf extract and the polydextrose as main raw materials can effectively generate a large intestine peristalsis stimulant to play a role in relaxing bowel, in addition, the addition of the angelica sinensis extract can reduce the irritation of the senna leaf extract, the fructus cannabis extract and the aloe whole leaf dry powder to a human body, and the polydextrose as a water-soluble extract can also play a role in reducing the irritation and relieving constipation, can regulate the balance of intestinal flora, promote the proliferation of beneficial bacteria such as bifidobacterium, inhibit the proliferation of harmful bacteria such as clostridium perfringens, and reduce carcinogens and putrefactive substances generated by bacterial fermentation.
Optionally, the aloe composition contains barbaloin 0.1-0.2g/100g, and total sennoside 0.6-0.8g/100g.
By adopting the technical scheme, when the contents of the effective functional components of the aloe composition, namely the barbaloin and the total sennoside, meet the content requirements, the obtained aloe composition has a better effect of relaxing bowel.
Optionally, the barbaloin in the whole leaf dry powder of aloe is more than or equal to 2500mg/kg.
Optionally, the content of total sennoside in the senna leaf extract is more than or equal to 8%.
By adopting the technical scheme, the contents of the barbaloin and the total sennoside of the final product aloe composition can meet the requirements by controlling the raw materials of the aloe whole-leaf dry powder and the senna leaf extract, and the excellent effect of relaxing bowel can be achieved.
Optionally, the aloe composition product is in the form of tablets, capsules or granules.
In a second aspect, the application provides an aloe capsule for relaxing bowel, which adopts the following technical scheme:
an aloe capsule for loosening bowel to relieve constipation comprises core material particles and a capsule shell, wherein the core material particles comprise the aloe composition.
By adopting the technical scheme, the aloe composition adopts a packaging form of capsules, relieves the irritation of the senna leaf extract and the like to digestive organs and respiratory tracts, protects the medicine property from being damaged, protects the digestive organs and the respiratory tracts and is also beneficial to taking.
Optionally, the capsule shell is gelatin capsule shell.
In a second aspect, the application provides a preparation method of an aloe capsule for relaxing bowel, which adopts the following technical scheme:
a preparation method of an aloe capsule for relaxing bowel comprises the following steps:
mixing raw materials: mixing Aloe whole leaf dry powder, fructus Cannabis extract, folium Psidii Guajavae extract, radix Angelicae sinensis extract and polydextrose, and making into raw material mixture;
filling: filling the raw material mixture into a capsule shell to obtain a primary aloe capsule;
polishing: polishing the primary aloe capsule to obtain the aloe capsule product.
By adopting the technical scheme, the method is simple and convenient, and industrialization is easy to realize.
Optionally, in the raw material mixing step, the aloe whole leaf dry powder, the fructus cannabis extract, the folium sennae extract and the angelica sinensis extract are mixed after being sieved by a 80-mesh sieve;
and (3) crushing the polydextrose, sieving the crushed polydextrose with a 80-mesh sieve, and mixing the polydextrose and the sieved polydextrose.
In summary, the present application has the following beneficial effects:
1. the aloe whole leaf dry powder, the fructus cannabis extract and the folium sennae extract are matched with each other, the aloe whole leaf dry powder and the folium sennae extract are particularly taken as main materials to play a role in relaxing bowel, and particularly compared with a traditional aloe capsule, the fructus cannabis extract and the folium sennae extract in the aloe whole leaf capsule replace partial barbadensis glucoside functional components, so that the aloe whole leaf dry powder, the fructus cannabis extract and the folium sennae extract can play a good role in relaxing bowel, even compared with a single aloe component, the effect of relaxing bowel is better, the adverse effect of overhigh aloe content on a human body is greatly reduced, and finally the aloe composition can play a better role in relaxing bowel under the condition of containing a lower aloe component;
2. the radix angelicae sinensis extract and the polydextrose are added, the radix angelicae sinensis is mild and has a certain effect of relaxing bowels, and meanwhile, the polydextrose added is used as water-soluble dietary fibers, cannot be degraded by intestinal digestive enzymes and only can be partially fermented by intestinal microorganisms to generate short-chain fatty acids, so that intestinal peristalsis is stimulated, water retention of excrement is improved, and the effect of preventing constipation is achieved.
Detailed Description
The present application is further described in detail with reference to the following examples, which are specifically illustrated by the following: the following examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer, and the starting materials used in the following examples are available from ordinary commercial sources unless otherwise specified.
In the following examples, the aloe whole leaf dry powder with the barbaloin content of more than or equal to 2500mg/kg is selected;
the folium sennae extract contains more than 8wt% of total sennoside.
Example 1
A preparation method of an aloe capsule for relaxing bowel comprises the following steps:
mixing raw materials: weighing aloe whole leaf dry powder, fructus cannabis extract, folium sennae extract, angelica sinensis extract and polydextrose, sieving the aloe whole leaf dry powder, fructus cannabis extract, folium sennae extract and angelica sinensis extract with a 80-mesh sieve, pulverizing the polydextrose to obtain polydextrose powder, and sieving with the 80-mesh sieve;
to prepare 1000 aloe capsules, 0.4g per capsule:
mixing aloe whole leaf dry powder 180g, fructus Cannabis extract 30g, folium sennae extract 30g, radix Angelicae sinensis extract 15g and polydextrose powder 100g, granulating to obtain raw material mixture;
filling: filling the raw material mixture into gelatin capsule shells to obtain primary aloe capsules;
polishing: polishing the primary aloe capsule to obtain the aloe capsule.
Example 2
A preparation method of an aloe capsule for relaxing bowel is carried out according to the method in the embodiment 1, and is characterized in that in the raw material mixing step, 200g of whole aloe leaf dry powder, 35g of fructus cannabis extract, 35g of folium sennae extract, 18g of angelica sinensis extract and 105g of polydextrose powder are mixed and granulated to obtain a raw material mixture.
Example 3
A preparation method of an aloe capsule capable of relaxing bowels is carried out according to the method in the embodiment 1, and the difference is that in the raw material mixing step, 220g of whole aloe leaf dry powder, 40g of fructus cannabis extract, 40g of folium sennae extract, 20g of angelica sinensis extract and 110g of polydextrose powder are mixed and granulated to obtain a raw material mixture.
Comparative example
Comparative example 1
A preparation method of aloe capsules for relaxing bowel is carried out according to the method in the embodiment 2, and is characterized in that the preparation method comprises the following steps of calculating by 1000 aloe capsules and 0.35g per capsule:
the raw materials are added with 227.5g of aloe concentrated powder, 70g of polydextrose and 52.5g of aloe whole leaf dry powder, the preparation method is the same as that in example 2, the raw materials are sieved by a sieve of 80 meshes, mixed, granulated, filled and polished to obtain the aloe capsule.
Comparative example 2
A preparation method of an aloe capsule for relaxing bowel is carried out according to the method in the embodiment 2, and is characterized in that fructus cannabis extract is not added in raw materials.
Comparative example 3
A preparation method of an aloe capsule for relaxing bowel is carried out according to the method in the embodiment 2, and is characterized in that no senna leaf extract is added in the raw materials.
Comparative example 4
A preparation method of an aloe capsule for relaxing bowel is carried out according to the method in the embodiment 2, and is characterized in that angelica sinensis extract is not added in raw materials.
Comparative example 5
A preparation method of an aloe capsule for relaxing bowel is carried out according to the method in the embodiment 2, and is characterized in that the angelica sinensis extract is equivalently replaced by polydextrose.
Comparative example 6
A preparation method of an aloe capsule for relaxing bowel is carried out according to the method in the embodiment 2, and is characterized in that a hemp seed extract is replaced by a cassia seed extract in equal amount.
Comparative example 7
A preparation method of an aloe capsule for relaxing bowel is carried out according to the method in the embodiment 2, and is characterized in that stachyose is replaced by polydextrose in equal amount.
Performance detection
1. Safety toxicology test
The specification of the aloe capsule prepared in the embodiment of the application is 0.4 g/granule, and the recommended dosage of a human body is as follows: 2 times daily, 3 granules each time.
The aloe capsule prepared in the example 2 of the application is entrusted to the disease prevention and control center of shanxi province for safety toxicology detection, and rat acute oral toxicity tests, three genetic toxicity tests and 28-day oral toxicity tests are respectively carried out, and the test results are as follows:
oral acute toxicity test in rats: aloe capsule for oral administration of LD to male and female rats 50 The dosage is more than 15.4g/kg.bw (385 times of the recommended amount of human body), and the acute oral toxicity of the rat belongs to non-toxic level;
the mouse bone marrow cell chromosome aberration test result is negative: the aloe capsule has no damage to the bone marrow cells of the test mice within the dosage range of 1.2g/kg.bw-4.8 g/kg.bw;
the mouse sperm aberration test result is negative: the aloe capsule has no mutagenic effect on germ cells of a test mouse within the dosage range of 1.2g/kg.bw to 4.8 g/kg.bw.
The result of the mouse sperm aberration test is negative. The result shows that the 'Si Jiang Paiqing Kang Luhui capsule' has no mutagenic effect on germ cells of experimental mice in the dosage range of 1.2-4.8 g/kg.
Rat 28-day oral toxicity test: the aloe capsule is in the dosage range of 1.2g/kg.bw to 4.8g/kg.bw, and has no obvious adverse effect on the growth and development, hematology, blood biochemistry, viscera and body ratio, pathological histology and the like of a test rat.
2. Bowel relaxing test
2.1 animal experiments
The test substance is a healthy adult second-grade Kunming female white mouse;
selecting the aloe capsule prepared in example 2, designing the aloe capsule into a high dose (1.2 g/kg.bw), a medium dose (0.6 g/kg.bw) and a low dose (0.3 g/kg.bw), additionally setting a constipation model control group (compound diphenoxylate 40 mg/kg.bw) and a negative control group (distilled water equal volume), orally intragastrically administering the test substance to the three dose groups once a day, continuously intragastrically administering the control group with distilled water equal volume for 10 days, and performing a small intestine propulsion test and a mouse defecation test, wherein the specific method is performed according to a defecation function test method in health food test and evaluation technical specification (2003 edition), and the results are as follows:
1. establishing a mouse constipation-causing model:
the indexes of the constipation model control group and the negative control group are compared as the following table 1:
table 1:
group of | Ink advancement rate/%) | First defecation time/min | 12h Total defecation volume/g | Number of defecation granules/granule for 12h |
Model comparison | 33.10±4.76 | 108.9±11.2 | 0.940±0.050 | 89.2±8.2 |
Negative control | 64.70±5.29 | 71.4±7.5 | 1.216±0.122 | 117.0±7.0 |
Value of T | 14.044 | 8.803 | 6.619 | 8.152 |
P value | <0.01 | <0.01 | <0.01 | <0.01 |
As can be seen from the above table 1, the propulsion rate of the ink for the small intestine of the mouse in the constipation model control group is obviously lower than that of the ink for the negative control group, the first defecation time is obviously prolonged, the total defecation amount in 12 hours and the defecation particle number in 12 hours are obviously reduced, the difference among all indexes is highly significant (P is less than 0.01), and the establishment of the constipation-causing model of the mouse is successful.
(2) The effect of aloe capsules on the rate of propulsion of ink in the small intestine of mice is shown in table 2 below:
table 2:
as can be seen from Table 2, the intestinal ink propulsion rate of mice was significantly increased in each dose group compared to the constipation model control group. The mouse intestinal propulsion test is a positive result. The aloe capsule can obviously promote the propulsion rate of the ink in the small intestine.
(3) The effect of aloe capsules on the initial defecation time of mice as well as the total defecation amount and number of defecation granules after 12h is shown in the following table 3:
table 3:
group of | First defecation time/min | 12h Total defecation volume/g | Number of defecation granules/granule for 12h |
High dose group | 76.1±7.8 | 1.120±0.142 | 105.6±16.0 |
Middle dose group | 80.0±10.0 | 1.090±0.144 | 97.4±12.1 |
Low dose group | 92.0±12.5 | 1.052±0.161 | 96.6±13.4 |
Model control group | 108.9±11.2 | 0.940±0.050 | 89.2±8.2 |
As can be seen from the above Table 3, the first defecation time of each dose group is obviously shortened compared with that of the constipation model group, and the defecation test of the mouse is a positive result.
In conclusion, the aloe capsule prepared in the application can obviously promote the propulsion rate of the small intestine ink and obviously shorten the first defecation time of a constipation-causing mouse, and the two tests are positive results, so that the aloe capsule can be judged to have the effect of relaxing bowel.
In order to consider the influence of the raw materials in the scheme of the application on the effect of relaxing bowel, the defecation test is performed according to the method in the example 2 on the aloe capsules obtained in the above examples and comparative examples, medium doses are selected for the aloe capsules in the other examples and comparative examples, the influence on the first defecation time of the mice after the doses are adopted is considered, and the statistical results are shown in the following table 4.
Table 4:
from the above table 4, it can be seen that when the aloe capsule product in the embodiment of the present application is adopted, compared with a constipation model group, the first defecation time of a mouse is obviously shortened, and the effect of relaxing bowel is achieved; referring to the detection results of the example 2 and the comparative example 1, it can be seen that the aloe capsule in the present application has better effect compared to the traditional aloe product with only aloe concentrated powder, polydextrose and aloe whole leaf dry powder, and the content of barbaloin in the aloe capsule prepared in the example of the present application is 0.1-0.2g/100g, and the content of abrotanin is 0.6-0.8g/100g, while the content of barbaloin in the aloe capsule with only aloe concentrated powder, polydextrose and aloe whole leaf dry powder in the comparative example 1 is 20g/100g, and the content of barbaloin in the example of the present application is greatly reduced, so that the influence on human body can be reduced, and the requirement of the current product on barbaloin content can be satisfied.
Referring to the detection results of the example 2 and the comparative examples 2 and 3, it can be seen that when the fructus cannabis extract or the folium sennae extract is not added to the raw materials, the first defecation time is much longer than that of the example 2, and the bowel relaxing effect is reduced; and by combining the detection result in the comparative example 6, when the fructus cannabis extract is replaced by other extracts in an equal amount, the first defecation time is longer, and the result is similar to the result in the comparative example 2, so that when the aloe whole leaf dry powder, the fructus cannabis extract and the folium sennae extract are used as the effective components and added with the three extracts, the bowel relaxing effect is better.
Combining the detection results of example 2, comparative example 4 and comparative example 5, it can be seen that the effect of relaxing bowel is reduced when the angelica extract is not added to the raw materials, and combining the detection result of comparative example 7, it can be seen that the effect is reduced when the same amount of polydextrose is replaced by other water-soluble dietary fibers. Moreover, no obvious diarrhea was observed in the mice during the aloe capsule test in the examples of the present application, while the mice in comparative examples 4-5 had slight diarrhea during the test, and the products in comparative examples 4 and 5 produced some irritation to the mice.
2.2 human feeding trial test
The aloe capsule prepared in example 2 is selected and tested according to a human body eating trial test in a defecation function test method in the technical specification for health food test and evaluation (2003), so that the defecation times of a food trial group are obviously increased and the defecation state integral is obviously reduced before and after eating the food trial, the difference is significant, the defecation times and the defecation state of the food trial group are obviously improved and the difference is significant, and the aloe capsule has a defecation function.
The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.
Claims (9)
1. The aloe composition for relaxing bowel is characterized by being prepared from the following raw materials in parts by weight:
180-220 parts of aloe whole leaf dry powder, 30-40 parts of fructus cannabis extract, 30-40 parts of folium sennae extract, 15-20 parts of angelica sinensis extract and 100-110 parts of polydextrose.
2. The aloe composition for relaxing bowel according to claim 1, wherein: the aloe composition contains barbaloin 0.1-0.2g/100g, and total sennoside 0.6-0.8g/100g.
3. The aloe composition for relaxing bowel according to claim 1, wherein: the aloin in the aloe whole leaf dry powder is more than or equal to 2500mg/kg.
4. The aloe composition for relaxing bowel according to claim 1, wherein: the content of total sennoside in the senna leaf extract is more than or equal to 8 percent.
5. The aloe composition for relaxing bowel according to claim 1, wherein: the aloe composition product is in the dosage form of tablets, capsules or granules.
6. An aloe capsule for relaxing bowel is characterized in that: comprising a core particle comprising an aloe composition according to any one of claims 1 to 5 and a shell.
7. The aloe capsule for relaxing bowel according to claim 6, wherein: the capsule shell is a bright capsule shell.
8. A method for preparing the aloe capsule for relaxing bowel according to claim 6 or 7, which is characterized by comprising the following steps: the method comprises the following steps:
mixing raw materials: mixing Aloe whole leaf dry powder, fructus Cannabis extract, folium Psidii Guajavae extract, radix Angelicae sinensis extract and polydextrose, and making into raw material mixture;
filling: filling the raw material mixture into a capsule shell to obtain a primary aloe capsule;
polishing: polishing the primary aloe capsule to obtain the aloe capsule product.
9. The preparation method of the aloe capsule for relaxing bowel according to claim 8, wherein the preparation method comprises the following steps: in the raw material mixing step, the aloe whole leaf dry powder, the fructus cannabis extract, the senna leaf extract and the angelica sinensis extract are sieved by a sieve of 80 meshes and then mixed;
and (3) crushing the polydextrose, sieving by a 80-mesh sieve, and mixing.
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张雷红等: "《天然药物化学》", vol. 4, 中国医药科技出版社, pages: 90 * |
陈秀锦: ""芦荟通便胶囊的人体试食试验评价"", 《海峡预防医学杂志》, vol. 21, no. 2, pages 62 - 63 * |
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