CN115135650A - 作为kras抑制剂的吡啶并嘧啶衍生物 - Google Patents

作为kras抑制剂的吡啶并嘧啶衍生物 Download PDF

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Publication number
CN115135650A
CN115135650A CN202180016066.8A CN202180016066A CN115135650A CN 115135650 A CN115135650 A CN 115135650A CN 202180016066 A CN202180016066 A CN 202180016066A CN 115135650 A CN115135650 A CN 115135650A
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CN
China
Prior art keywords
alkyl
compound
disease
patient
kras
Prior art date
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Pending
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CN202180016066.8A
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English (en)
Chinese (zh)
Inventor
张顿
彭继荣
迈克尔·约翰·科斯坦佐
迈克尔·艾伦·格林
迈克尔·尼古拉斯·格雷科
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Beta Pharma Inc
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Beta Pharma Inc
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Publication of CN115135650A publication Critical patent/CN115135650A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202180016066.8A 2020-02-20 2021-02-19 作为kras抑制剂的吡啶并嘧啶衍生物 Pending CN115135650A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062978954P 2020-02-20 2020-02-20
US62/978,954 2020-02-20
PCT/US2021/018703 WO2021168193A1 (en) 2020-02-20 2021-02-19 Pyridopyrimidine derivatives as kras inhibitors

Publications (1)

Publication Number Publication Date
CN115135650A true CN115135650A (zh) 2022-09-30

Family

ID=77391707

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180016066.8A Pending CN115135650A (zh) 2020-02-20 2021-02-19 作为kras抑制剂的吡啶并嘧啶衍生物

Country Status (6)

Country Link
US (1) US20230099858A1 (https=)
EP (1) EP4077328A4 (https=)
JP (1) JP2023515479A (https=)
CN (1) CN115135650A (https=)
AU (1) AU2021224733A1 (https=)
WO (1) WO2021168193A1 (https=)

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MX2022002465A (es) 2019-08-29 2022-05-19 Mirati Therapeutics Inc Inhibidores de kras g12d.
WO2021061749A1 (en) 2019-09-24 2021-04-01 Mirati Therapeutics, Inc. Combination therapies
PH12022551513A1 (en) 2019-12-20 2023-04-24 Mirati Therapeutics Inc Sos1 inhibitors
US20250195521A1 (en) 2020-09-03 2025-06-19 Revolution Medicines, Inc. Use of sos1 inhibitors to treat malignancies with shp2 mutations
EP4210833A4 (en) 2020-09-11 2024-09-11 Mirati Therapeutics, Inc. CRYSTALLINE FORMS OF A KRAS G12C INHIBITOR
CA3194067A1 (en) 2020-09-15 2022-03-24 Revolution Medicines, Inc. Ras inhibitors
WO2022061251A1 (en) * 2020-09-18 2022-03-24 Plexxikon Inc. Compounds and methods for kras modulation and indications therefor
JP2023544450A (ja) 2020-09-23 2023-10-23 エラスカ・インコーポレイテッド 三環式ピリドン及びピリミドン
JP2023553492A (ja) 2020-12-15 2023-12-21 ミラティ セラピューティクス， インコーポレイテッド アザキナゾリン汎ＫＲａｓ阻害剤
EP4262803A4 (en) 2020-12-16 2025-03-12 Mirati Therapeutics, Inc. Tetrahydropyridopyrimidine pan-kras inhibitors
WO2022133345A1 (en) 2020-12-18 2022-06-23 Erasca, Inc. Tricyclic pyridones and pyrimidones
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WO2022171191A1 (en) * 2021-02-11 2022-08-18 Jingrui Biopharma Co., Ltd. Compounds as anticancer agents
TWI810803B (zh) * 2021-03-15 2023-08-01 大陸商藥雅科技（上海）有限公司 突變蛋白抑制劑的製備及其應用
TWI814234B (zh) * 2021-03-15 2023-09-01 大陸商藥雅科技（上海）有限公司 突變蛋白抑制劑的製備及其應用
KR20240017811A (ko) 2021-05-05 2024-02-08 레볼루션 메디슨즈, 인크. 암의 치료를 위한 ras 억제제
TW202309052A (zh) 2021-05-05 2023-03-01 美商銳新醫藥公司 Ｒａｓ抑制劑
US20240300980A1 (en) * 2021-05-22 2024-09-12 Shanghai Kechow Pharma, Inc. Heterocyclic compounds as kras inhibitor, and preparation therefor and use thereof in treatment
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US20250250286A1 (en) * 2021-11-30 2025-08-07 Beta Pharma, Inc. Fused pyrimidine derivatives as kras oncoprotein inhibitors
CN119212994A (zh) 2021-12-17 2024-12-27 建新公司 作为shp2抑制剂的吡唑并吡嗪化合物
EP4227307A1 (en) 2022-02-11 2023-08-16 Genzyme Corporation Pyrazolopyrazine compounds as shp2 inhibitors
JP2025510572A (ja) 2022-03-08 2025-04-15 レボリューション メディシンズ インコーポレイテッド 免疫不応性肺癌を治療するための方法
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JP2026503866A (ja) * 2022-10-31 2026-02-02 ベータ・ファーマ・インコーポレイテッド Ｋｒａｓオンコプロテイン阻害剤としての１，５－ナフチリジン誘導体
CN120659773A (zh) 2022-11-09 2025-09-16 锐新医药公司 化合物、复合物以及其制备方法和用途
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TW202508595A (zh) 2023-05-04 2025-03-01 美商銳新醫藥公司 用於ｒａｓ相關疾病或病症之組合療法
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116120315A (zh) * 2023-04-19 2023-05-16 山东绿叶制药有限公司 一种kras g12c抑制剂及其应用
CN116120315B (zh) * 2023-04-19 2023-06-09 山东绿叶制药有限公司 一种kras g12c抑制剂及其应用

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US20230099858A1 (en) 2023-03-30
WO2021168193A1 (en) 2021-08-26
JP2023515479A (ja) 2023-04-13
EP4077328A1 (en) 2022-10-26
EP4077328A4 (en) 2023-11-29
AU2021224733A1 (en) 2022-09-01

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