CN115120654B - Traditional Chinese medicine composition for nourishing liver and protecting eyes of children and preparation method thereof - Google Patents
Traditional Chinese medicine composition for nourishing liver and protecting eyes of children and preparation method thereof Download PDFInfo
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- CN115120654B CN115120654B CN202210748093.0A CN202210748093A CN115120654B CN 115120654 B CN115120654 B CN 115120654B CN 202210748093 A CN202210748093 A CN 202210748093A CN 115120654 B CN115120654 B CN 115120654B
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Classifications
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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Abstract
The invention relates to a traditional Chinese medicine composition for nourishing liver and protecting eyes of children and a preparation method of instant granules thereof. The traditional Chinese medicine composition for children liver nourishing and eye protecting is prepared from the following raw materials in parts by weight: 10-30 parts of kudzuvine root, 3-20 parts of five-finger wild peach, 1-15 parts of liquorice, 1-13 parts of hovenia dulcis thunb, 0.5-10 parts of medlar, 0.5-8 parts of ginseng and 0.5-5 parts of chrysanthemum. The invention has the advantages of high bioavailability, high safety, good stability, definite efficacy and the like.
Description
Technical Field
The invention relates to the technical field of foods, in particular to a traditional Chinese medicine composition for nourishing liver and protecting eyes of children and a preparation method thereof.
Background
At present, the eye-protecting food for children mainly contains vitamins A, vitamin B, zinc, anthocyanin, lutein and other nutrients with eye-protecting effects, and has the advantages of general product effects and serious homogenization. The traditional Chinese medicine-containing products in the existing products are mainly prepared by traditional water decoction and extraction, the extraction rate of active ingredients is low, the bioavailability is low, and the efficacy of the products is not obvious. The products are sold on the market in the forms of health-care tea, beverage and decoction, the acceptance of children is low, and the stability of the products is poor. The efficacy evaluation of the existing product mostly takes a human body as a subject, the evaluation index and the safety are not clear, and the efficacy evaluation result is too subjective and has no statistical significance. Meanwhile, related researches show that the nutrient supplement is not required to be supplemented in a supplement form, but is easier to be absorbed by human bodies in a dietotherapy form of fruits and vegetables, foods and the like with homology of medicine and food.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for children liver nourishing and eye protection and a preparation method thereof, and the traditional Chinese medicine composition is matched with a unique preparation method and has the advantages of high bioavailability, high safety, good stability, definite efficacy and the like. .
In order to achieve the above purpose, the technical scheme of the invention is as follows:
the traditional Chinese medicine composition for children liver nourishing and eye protecting is prepared from the following raw materials in parts by weight:
10-30 parts of kudzuvine root, 3-20 parts of five-finger wild peach, 1-15 parts of liquorice, 1-13 parts of hovenia dulcis thunb, 0.5-10 parts of medlar, 0.5-8 parts of ginseng and 0.5-5 parts of chrysanthemum.
Preferably, the material is prepared from the following raw materials in parts by weight:
12-20 parts of kudzuvine root, 8-15 parts of five-finger wild peach, 3-8 parts of liquorice, 2-5 parts of hovenia dulcis thunb, 2-5 parts of medlar, 1-3 parts of ginseng and 1-3 parts of chrysanthemum.
The preparation method of the active ingredients of the traditional Chinese medicine composition for children liver nourishing and eye protecting comprises the following steps:
A. taking all the traditional Chinese medicinal materials, cleaning and drying, pulverizing into coarse powder, performing enzymolysis, filtering to obtain traditional Chinese medicine enzymolysis liquid, and filtering residues for later use;
B. and C, mixing the residues obtained in the step A according to a feed liquid ratio of 1: 8-10, adding 45-80% ethanol at 18-30 ℃ for leaching for 6-10 h, and filtering to obtain a low Wen Chundi liquid of the traditional Chinese medicine;
C. vacuum concentrating the Chinese medicine enzymolysis liquid and the Chinese medicine low Wen Chundi liquid respectively to the relative density of 1.10-1.40 to obtain Chinese medicine enzymolysis concentrated liquid and Chinese medicine low Wen Chundi concentrated liquid;
D. mixing the Chinese medicinal enzymolysis concentrated solution and the Chinese medicinal low Wen Chundi concentrated solution, and spray drying to obtain dry extract powder.
In the step A, all the traditional Chinese medicinal materials are washed and dried, and then crushed into coarse powder with 10-24 meshes.
In the step A, the enzymolysis comprises the following steps:
adding 5-10 times of water in the total amount of the medicinal materials, regulating the pH to 3.0-7.0 by using citric acid or edible alkali solution, heating to 35-80 ℃, respectively adding cellulase and pectase according to the amount of 5-40 ten thousand U/g of medicinal materials, and carrying out enzymolysis for 3-8 hours at the constant temperature of 35-80 ℃, heating and boiling to inactivate the enzymes.
In the step D, the spray drying conditions are as follows: the air inlet temperature is 180-220 ℃, and the air outlet temperature is 90-100 ℃.
The preparation method of the instant granule also comprises the following steps:
E. and D, placing the dry extract powder prepared in the step D, the flavoring agent and the diluent at the bottom of a one-step granulator, uniformly mixing, and spraying a water-soluble starch solution with the relative density of 1.10-1.30 at the temperature of 45-65 ℃ at the spraying speed of 40-70 ml/min and the air inlet temperature of 70-90 ℃ under the atomizing pressure of 0.1-0.3 MPa to prepare instant granules.
The invention starts from the screening of traditional Chinese medicine classical prescriptions, and optimizes prescriptions based on the decoction of the traditional Chinese medicine classical prescriptions for replenishing qi and improving intelligence. The Yi Qi-Smart decoction is a classical prescription of one of four members Li Donghuan of the famous medical doctor of traditional Chinese medicine, and is received in Ji Wu from Dong Yuan Yi Fang, and the decoction is composed of astragalus root, ginseng, licorice, kudzu vine root, peony root, phellodendron bark, cimicifuga rhizome and fructus viticis. Has effects of invigorating qi, invigorating yang, improving hearing and improving eyesight. The main indications are improper diet, spleen and stomach deficiency, tinnitus or years of dark eyes, and inability to see the object. Modern researches have proved that the recipe has the effect of treating ophthalmic diseases such as optic atrophy, central serous chorioretinitis and achromatopsia.
On the basis of following the principle of using the original prescription, the invention selects the medicine-food homologous traditional Chinese medicine to reform, consists of kudzuvine root, fiveleaf fissistigma herb, ginseng, chrysanthemum, liquorice, hovenia dulcis thunb and medlar, and uses kudzuvine root and fiveleaf fissistigma herb to enhance the efficacy of rising clear yang.
The invention is innovated in the production process, and is intended to be combined with the modern technologies of safe and efficient biological enzymolysis method, one-step granulating, boiling drying, instant forming process and the like to prepare the instant granules.
The invention has the advantages of high bioavailability, high safety, good stability and definite efficacy.
Drawings
FIG. 1 is a graph of the ratio of iris bandwidth to pupil diameter of a treated zebra fish;
FIG. 2 is a comparison of liver injury improvement effects of zebra fish after treatment;
Detailed Description
The invention is further illustrated by the following examples. It should be understood that the examples of the present invention are intended to illustrate the present invention and not to limit the present invention. Simple modifications of the invention in accordance with the essence of the invention are all within the scope of the invention as claimed. Unless otherwise indicated, percentages of ethanol amounts in the present invention are volume percentages.
Example 1
The traditional Chinese medicine composition for children liver nourishing and eye protecting is prepared from the following raw materials in parts by weight:
10kg of kudzuvine root, 3kg of five-finger wild peach, 1kg of liquorice, 1kg of hovenia dulcis thunb, 0.5kg of medlar, 0.5kg of ginseng and 0.5kg of chrysanthemum.
The preparation method of the active ingredient and the instant granule comprises the following steps:
A. taking all the traditional Chinese medicinal materials, cleaning and drying, pulverizing into coarse powder of 10 meshes, carrying out enzymolysis, filtering to obtain traditional Chinese medicine enzymolysis liquid, and filtering residues for later use;
the enzymolysis process is as follows: adding 5 times of water, adjusting pH to 3.0 with citric acid or edible alkali solution, heating to 35, adding cellulase and pectase respectively according to 5U/g of medicinal materials, performing enzymolysis at 35deg.C for 3 hr, heating to boil, and inactivating enzyme;
B. and C, mixing the residues obtained in the step A according to a feed liquid ratio of 1:8, adding 45% ethanol, leaching at 18 ℃ for 6 hours, and filtering to obtain a low Wen Chundi liquid of the traditional Chinese medicine;
C. vacuum concentrating the Chinese medicinal enzymolysis liquid and Chinese medicinal low Wen Chundi liquid respectively to relative density of 1.10 to obtain Chinese medicinal enzymolysis concentrated liquid and Chinese medicinal low Wen Chundi concentrated liquid;
D. mixing the Chinese medicinal enzymolysis concentrated solution and the Chinese medicinal low Wen Chundi concentrated solution, and spray drying to obtain dry extract powder;
the spray drying conditions were: the inlet air temperature is 180 ℃ and the outlet air temperature is 90 DEG C
E. And D, placing the dry extract powder prepared in the step D, the flavoring agent and the diluent at the bottom of a one-step granulator, uniformly mixing, spraying a water-soluble starch solution with the relative density of 1.10 at the spraying speed of 40ml/min and the air inlet temperature of 70 ℃ under the atomizing pressure of 0.1MPa, and preparing instant granules.
Example 2
The traditional Chinese medicine composition for children liver nourishing and eye protecting is prepared from the following raw materials in parts by weight:
30kg of kudzuvine root, 20kg of five-finger wild peach, 15kg of liquorice, 13kg of hovenia dulcis thunb, 10kg of medlar, 8kg of ginseng and 5kg of chrysanthemum.
The preparation method of the active ingredient and the instant granule comprises the following steps:
A. taking all the traditional Chinese medicinal materials, cleaning and drying, pulverizing into 24-mesh coarse powder, performing enzymolysis, filtering to obtain traditional Chinese medicinal enzymolysis liquid, and filtering residues for later use;
the enzymolysis process is as follows: adding water 10 times of the total amount of the medicinal materials, regulating pH to 7.0 with citric acid or edible alkali solution, heating to 80deg.C, adding cellulase and pectase respectively according to the amount of 40U/g medicinal materials, performing enzymolysis at 80deg.C for 8 hr, heating to boil, and inactivating enzyme;
B. and C, mixing the residues obtained in the step A according to a feed liquid ratio of 1:10, adding 80% ethanol, leaching at 30deg.C for 10h, filtering to obtain a low Wen Chundi liquid;
C. vacuum concentrating the Chinese medicinal enzymolysis liquid and Chinese medicinal low Wen Chundi liquid respectively to relative density of 1.40 to obtain Chinese medicinal enzymolysis concentrated liquid and Chinese medicinal low Wen Chundi concentrated liquid;
D. mixing the Chinese medicinal enzymolysis concentrated solution and the Chinese medicinal low Wen Chundi concentrated solution, and spray drying to obtain dry extract powder;
the spray drying conditions were: the air inlet temperature is 220 ℃ and the air outlet temperature is 100 DEG C
E. And D, placing the dry extract powder prepared in the step D, the flavoring agent and the diluent at the bottom of a one-step granulator, uniformly mixing, spraying a 65 ℃ water-soluble starch solution with the relative density of 1.30 at the spraying speed of 70ml/min and the air inlet temperature of 90 ℃ under the atomizing pressure of 0.3MPa, and preparing instant granules.
Example 3
The traditional Chinese medicine composition for children liver nourishing and eye protecting is prepared from the following raw materials in parts by weight:
12kg of kudzuvine root, 8kg of five-finger wild peach, 3kg of liquorice, 2kg of hovenia dulcis thunb, 2kg of medlar, 1kg of ginseng and 1kg of chrysanthemum.
The preparation method of the active ingredient and the instant granule comprises the following steps:
A. taking all the traditional Chinese medicinal materials, cleaning and drying, pulverizing into coarse powder of 15 meshes, carrying out enzymolysis, filtering to obtain traditional Chinese medicine enzymolysis liquid, and filtering residues for later use;
the enzymolysis process is as follows: adding water 6 times of the total amount of the medicinal materials, regulating pH to 5.0 with citric acid or edible alkali solution, heating to 50deg.C, adding cellulase and pectase respectively according to the amount of 20U/g medicinal materials, performing enzymolysis at 50deg.C for 5 hr, heating to boil, and inactivating enzyme;
B. and C, mixing the residues obtained in the step A according to a feed liquid ratio of 1:9, adding 60% ethanol, leaching for 8 hours at 23 ℃, and filtering to obtain a low Wen Chundi liquid of the traditional Chinese medicine;
C. vacuum concentrating the Chinese medicinal enzymolysis liquid and Chinese medicinal low Wen Chundi liquid respectively to relative density of 1.30 to obtain Chinese medicinal enzymolysis concentrated liquid and Chinese medicinal low Wen Chundi concentrated liquid;
D. mixing the Chinese medicinal enzymolysis concentrated solution and the Chinese medicinal low Wen Chundi concentrated solution, and spray drying to obtain dry extract powder;
the spray drying conditions were: the air inlet temperature is 200 ℃, and the air outlet temperature is 95 DEG C
E. And D, placing the dry extract powder prepared in the step D, the flavoring agent and the diluent at the bottom of a one-step granulator, uniformly mixing, spraying a water-soluble starch solution with the relative density of 1.20 at the air inlet temperature of 80 ℃ at the atomizing pressure of 0.2MPa and the atomizing speed of 50ml/min, and preparing instant granules.
Example 4
The traditional Chinese medicine composition for children liver nourishing and eye protecting is prepared from the following raw materials in parts by weight:
20kg of kudzuvine root, 15kg of five-finger wild peach, 8kg of liquorice, 5kg of hovenia dulcis thunb, 5kg of medlar, 3kg of ginseng and 3kg of chrysanthemum.
The preparation method of the active ingredient and the instant granule comprises the following steps:
A. taking all the traditional Chinese medicinal materials, cleaning and drying, pulverizing into coarse powder of 18 meshes, carrying out enzymolysis, filtering to obtain traditional Chinese medicine enzymolysis liquid, and filtering residues for later use;
the enzymolysis process is as follows: adding 8 times of water, adjusting pH to 6.0 with citric acid or edible alkali solution, heating to 7deg.C, adding cellulase and pectase respectively according to 30U/g of medicinal materials, performing enzymolysis at 60deg.C for 4 hr, heating to boil, and inactivating enzyme;
B. and C, mixing the residues obtained in the step A according to a feed liquid ratio of 1:8, adding 50% ethanol, leaching at 27 ℃ for 7h, and filtering to obtain a low Wen Chundi liquid of the traditional Chinese medicine;
C. vacuum concentrating the Chinese medicinal enzymolysis liquid and Chinese medicinal low Wen Chundi liquid respectively to relative density of 1.20 to obtain Chinese medicinal enzymolysis concentrated solution and Chinese medicinal low Wen Chundi concentrated solution;
D. mixing the Chinese medicinal enzymolysis concentrated solution and the Chinese medicinal low Wen Chundi concentrated solution, and spray drying to obtain dry extract powder;
the spray drying conditions were: the air inlet temperature is 190 ℃, and the air outlet temperature is 93 DEG C
E. And D, placing the dry extract powder prepared in the step D, the flavoring agent and the diluent at the bottom of a one-step granulator, uniformly mixing, spraying a 50 ℃ water-soluble starch solution with the relative density of 1.22 at the atomizing pressure of 0.3MPa, the spraying speed of 60ml/min and the air inlet temperature of 75 ℃, and preparing instant granules.
Example 5
The traditional Chinese medicine composition for children liver nourishing and eye protecting is prepared from the following raw materials in parts by weight:
16kg of kudzuvine root, 12kg of five-finger wild peach, 5kg of liquorice, 4kg of hovenia dulcis thunb, 4kg of medlar, 2kg of ginseng and 2kg of chrysanthemum.
The preparation method of the active ingredient and the instant granule comprises the following steps:
A. taking all the traditional Chinese medicinal materials, cleaning and drying, pulverizing into coarse powder of 0 mesh, performing enzymolysis, filtering to obtain traditional Chinese medicine enzymolysis liquid, and filtering residues for later use;
the enzymolysis process is as follows: adding 8 times of water, adjusting pH to 4.0 with citric acid or edible alkali solution, heating to 50deg.C, adding cellulase and pectase respectively according to the amount of 25U/g of the medicinal materials, performing enzymolysis at 50deg.C for 6 hr, heating to boil, and inactivating enzyme;
B. and C, mixing the residues obtained in the step A according to a feed liquid ratio of 1:9, adding 55% ethanol, leaching at 25 ℃ for 8 hours, and filtering to obtain a traditional Chinese medicine low Wen Chundi liquid;
C. vacuum concentrating the Chinese medicinal enzymolysis liquid and Chinese medicinal low Wen Chundi liquid respectively to relative density of 1.22 to obtain Chinese medicinal enzymolysis concentrated liquid and Chinese medicinal low Wen Chundi concentrated liquid;
D. mixing the Chinese medicinal enzymolysis concentrated solution and the Chinese medicinal low Wen Chundi concentrated solution, and spray drying to obtain dry extract powder;
the spray drying conditions were: the air inlet temperature is 200 ℃, and the air outlet temperature is 92 DEG C
E. And D, placing the dry extract powder prepared in the step D, the flavoring agent and the diluent at the bottom of a one-step granulator, uniformly mixing, spraying a 60 ℃ water-soluble starch solution with the relative density of 1.23 at the spraying speed of 50ml/min and the air inlet temperature of 80 ℃ under the atomizing pressure of 0.23MPa, and preparing instant granules.
Example 6
Efficacy evaluation method and results:
(1) Method for evaluating protection effect of product on zebra fish drug-induced eye injury by using zebra fish disease model
Benzalkonium bromide and ethylparaben are preservatives widely used in ophthalmic formulations, and their accumulation on the ocular surface is an important factor causing drug toxicity of ophthalmic formulations. Experiments randomly select 150-tail 3dpf zebra fish with normal development in six-hole plates, 30-tail each hole is treated by taking 0.1% DMSO as a control group, and the model group is placed in a mixed liquid medicine of benzalkonium bromide (5 mug/ml) and ethyl hydroxy benzoate (20 mug/ml) to induce zebra fish eye injury. Administration group example 5 was given instant granule concentrations of 10, 20 and 40 μg/mL with a 3mL per well capacity. Culturing at 28.5deg.C for 72 hr, changing liquid once every 24 hr, and observing the eye morphology change of the young zebra fish under a microscope. Iris bandwidth and pupil diameter were measured using Image J software and the ratio of the two was calculated.
As shown in fig. 1, compared with the normal control group, the control group of the eye injury model has the advantages that the ratio of the iris bandwidth to the pupil diameter of the zebra fish is obviously reduced, the iris edge is irregular, and the result is similar to the tearing or fracture symptoms of the human iris sphincter, so that the model is successfully established; the instant particles 10, 20 and 40 mug/mL mass concentration groups of the embodiment 5 have an improvement effect on the iris bandwidth and pupil diameter of the zebra fish, namely the low dose group, the medium dose group and the high dose group in the figure, wherein the ratio of the low dose group to the medium dose group to the high dose group is 4.65, 5.53 to 7.62, and the p is less than 0.01. The instant granules for nourishing the liver and protecting the eyes of children are proved to have the effect of repairing the damage of the eyes of the young zebra fish induced by benzalkonium bromide and ethyl hydroxybenzoate.
(2) Evaluation of product's protective action on zebra fish liver using zebra fish disease model
180 3d zebra fish were randomly selected in six well plates, 30 tails per well, and acetaminophen was used to induce liver damage in the zebra fish. The instant particle concentrations of example 5 were given at 10, 20 and 40. Mu.g/mL, respectively, with a positive control N-acetylcysteine (NAC) concentration of 1.5. Mu.g/mL, while setting the normal control and model control at 3mL per well. Example 5 after 48h of co-treatment of instant particles with acetaminophen, 10 zebra fish were randomly selected from each experimental group, photographed under a microscope and data were collected, and zebra fish liver area (a), liver brightness average (S) and yolk sac absorption delay area (a) were calculated for quantitative analysis, and statistics were performed, and the statistical treatment results were expressed in mean±se. Example 5 the calculation formula for the instant granule liver injury protection is as follows:
wherein A1 to A3, S1 to S3 and A4 to A6 are respectively the liver area, liver brightness and yolk sac absorption delay area of the normal control group, the model control group and the instant granule experimental group of example 5. The experimental results are shown in table 1 below and fig. 2.
As shown in table 1 and fig. 2, the significant differences of the liver area, the liver brightness average value and the yolk sac absorption delay area of the zebra fish are p < 0.01 compared with the normal control group, which indicates that the model establishment is successful; the positive control drug NAC1.5 mug/mL mass concentration group has an improvement effect (the improvement effect is 40 percent, and p is less than 0.01) on the liver degeneration of the zebra fish, but has no obvious improvement effect on the liver atrophy of the zebra fish and the absorption delay of the yolk sac; example 5 instant particles 10, 20 and 40. Mu.g/mL mass concentration groups all had an improvement in liver degeneration in zebra fish (low, medium and high dose groups improved by 37%, 52%, respectively),
Table 1 liver protection of zebra fish after treatment (n=30)
Note that: in comparison with the control group of the model, * p＜0.01。
74%, p < 0.01). The instant granules for children to nourish liver and protect eyes are proved to have the effect of protecting liver.
Claims (6)
1. The traditional Chinese medicine composition for protecting the eyes of children is characterized by being prepared from the following raw materials in parts by weight:
12-20 parts of kudzuvine root, 8-15 parts of five-finger wild peach, 3-8 parts of liquorice, 2-5 parts of hovenia dulcis thunb, 2-5 parts of medlar, 1-3 parts of ginseng and 1-3 parts of chrysanthemum.
2. The traditional Chinese medicine composition for protecting eyes of children according to claim 1, wherein the preparation method of the active ingredients comprises the following steps:
A. taking all the traditional Chinese medicinal materials, cleaning and drying, pulverizing into coarse powder, performing enzymolysis, filtering to obtain traditional Chinese medicine enzymolysis liquid, and filtering residues for later use;
B. and C, mixing the residues obtained in the step A according to a feed liquid ratio of 1: 8-10, adding 45-80% ethanol at 18-30 ℃ for leaching for 6-10 h, and filtering to obtain a low Wen Chundi liquid of the traditional Chinese medicine;
C. vacuum concentrating the Chinese medicine enzymolysis liquid and the Chinese medicine low Wen Chundi liquid respectively to the relative density of 1.10-1.40 to obtain Chinese medicine enzymolysis concentrated liquid and Chinese medicine low Wen Chundi concentrated liquid;
D. mixing the Chinese medicinal enzymolysis concentrated solution and the Chinese medicinal low Wen Chundi concentrated solution, and spray drying to obtain dry extract powder.
3. The traditional Chinese medicine composition for child eye protection according to claim 2, wherein: in the step A, all the traditional Chinese medicinal materials are washed and dried, and then crushed into coarse powder with 10-24 meshes.
4. The traditional Chinese medicine composition for child eye protection according to claim 2, wherein:
in the step A, the enzymolysis comprises the following steps:
adding 5-10 times of water in the total amount of the medicinal materials, regulating the pH to 3.0-7.0 by using citric acid or edible alkali solution, heating to 35-80 ℃, respectively adding cellulase and pectase according to the amount of 5-40 ten thousand U/g of medicinal materials, and carrying out enzymolysis for 3-8 hours at the constant temperature of 35-80 ℃, heating and boiling to inactivate the enzymes.
5. The traditional Chinese medicine composition for child eye protection according to claim 2, wherein: in the step D, the spray drying conditions are as follows: the air inlet temperature is 180-220 ℃, and the air outlet temperature is 90-100 ℃.
6. The traditional Chinese medicine composition for protecting eyes of children according to claim 2, wherein the preparation method for further preparing instant granules further comprises the following steps:
E. and D, placing the dry extract powder prepared in the step D, the flavoring agent and the diluent at the bottom of a one-step granulator, uniformly mixing, and spraying a water-soluble starch solution with the relative density of 1.10-1.30 at the temperature of 45-65 ℃ at the spraying speed of 40-70 ml/min and the air inlet temperature of 70-90 ℃ under the atomizing pressure of 0.1-0.3 MPa to prepare instant granules.
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| CN111406814A (en) * | 2020-05-03 | 2020-07-14 | 桃源县万羊山生态农业科技发展有限公司 | Production method of selenium-rich Huang chrysanthemum and wolfberry tea |
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| CN111406814A (en) * | 2020-05-03 | 2020-07-14 | 桃源县万羊山生态农业科技发展有限公司 | Production method of selenium-rich Huang chrysanthemum and wolfberry tea |
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