CN113117039A

CN113117039A - Method for preparing Guilong Kechuanning tablet

Info

Publication number: CN113117039A
Application number: CN202010034234.3A
Authority: CN
Inventors: 潘民儒; 谭秋; 戚火珍; 郑伟刚; 张耀月; 覃素霞
Original assignee: Guangxi Tainuo Pharmaceutical Co ltd
Current assignee: Guangxi Tainuo Pharmaceutical Co ltd
Priority date: 2020-01-13
Filing date: 2020-01-13
Publication date: 2021-07-16

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a preparation method of Guilong Kechuanning tablets. The preparation method of the Guilong Kechuanning tablet is characterized by comprising the following components in parts by weight: 8.6% of cassia twig, 17.2% of dragon bone, 8.6% of white peony root, 8.6% of ginger, 8.6% of Chinese date, 5.2% of honey-fried licorice root, 17.2% of oyster, 1.8% of coptis root, 7.8% of rhizoma pinellinae praeparata, 8.6% of trichosanthes peel and 7.8% of bitter almond (fried); a proper amount of water; the preparation method comprises the following steps: firstly, preprocessing and weighing for later use; secondly, powdering; thirdly, extracting; fourthly, concentrating; fifthly, preparation; the invention has the beneficial effects that: the cassia twig and the white paeony root are pretreated, and the cassia twig is pretreated and dried for three times, so that the medicinal materials are loose, porous and easy to crush, and the preparation is more convenient; the white paeony root is dried for a plurality of times, so that the medicinal materials are easier to crush, therefore, the preparation of the medicine is improved through the improvement of the process, and the white paeony root medicinal powder has good popularization value.

Description

Method for preparing Guilong Kechuanning tablet

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a preparation method of Guilong Kechuanning tablets.

Background

The Guilong Kechuanning tablet is prepared by extracting and concentrating a plurality of traditional Chinese medicines such as cassia twig, white paeony root and the like, the cassia twig is pungent, sweet and warm in nature, enters lung, heart and bladder channels, is a commonly used interior warming medicine for mainly treating interior cold, and has the effects of tonifying primordial yang, promoting blood circulation and warming spleen and stomach; the keel has sweet taste, is mild, can calm the nerves, can arrest sweating and control nocturnal emission, can stop bleeding and astringe intestines, and can promote tissue regeneration and heal wound; the white peony root is bitter and sour in taste and slightly cold, and has the effects of nourishing blood, regulating menstruation, astringing yin, suppressing sweating, calming liver yang and the like; ginger is pungent in flavor and slightly warm in nature, has the effects of relieving exterior syndrome, dispelling cold, warming middle-jiao to relieve cough, and eliminating phlegm to relieve cough; the Chinese dates are sweet in taste and warm, and have the effects of tonifying middle-jiao and Qi, nourishing blood and soothing nerves; the honey-fried licorice root is sweet and neutral in taste, and has the effects of tonifying spleen and stomach, and tonifying qi and recovering pulse; oyster is salty in taste and slightly cold in nature, has the effects of tranquilizing mind, suppressing yang, tonifying yin, softening hardness and dissipating stagnation; coptis root, rhizoma Coptidis, being bitter and cold in flavor, has the effects of clearing heat and eliminating dampness, purging fire and removing toxicity; rhizoma Pinelliae Preparata is pungent in flavor, warm in nature, and can eliminate dampness and phlegm; the snakegourd peel is sweet and cold in taste, can clear heat and reduce phlegm, promote qi circulation and relieve chest stuffiness, and the bitter apricot kernels are bitter in taste and slightly cold in nature, can lower qi, relieve cough and asthma, and moisten intestines to relieve constipation; the medicines are combined, have the main effects of stopping cough and reducing phlegm, and lowering qi and relieving asthma, and are used for treating cough, asthma and other symptoms caused by wind cold or phlegm-damp and qi obstruction of lung; and acute and chronic bronchitis.

Pulverizing ramulus Cinnamomi and radix Paeoniae alba (1/2), grinding fructus Amomi, grinding the rest radix Paeoniae alba (1/2), rhizoma Zingiberis recens, Os Draconis, fructus Jujubae, radix Glycyrrhizae Preparata, Concha Ostreae, Coptidis rhizoma, rhizoma Pinelliae Preparata, pericarpium Trichosanthis, and semen Armeniacae amarum (parched), decocting in water, concentrating to appropriate amount, mixing with above powder, sucking into concentrated solution, and drying. The effective components in the cassia twig can not be fully utilized by directly crushing the cassia twig, and the cassia twig in some medicines is directly and commonly dried at the temperature of below 80 ℃ and is not greatly helpful for preparing the medicines. The effective components of medicines with poor water extraction effect, such as white paeony root, can not be fully dissolved out only by decocting with water, the utilization degree is not high, and the white paeony root has heat sensitivity, and the effective components are easily decomposed after drying at high temperature, so that the research on the processes, such as strengthening the pretreatment, is necessary for the components, particularly the main components of cassia twig and white paeony root, so as to better release the effective components, and the whole preparation process flow is modified so as to prepare the high-quality Guilong Kechuanning tablet, thereby creating higher market value.

Related patents are applied for technical schemes of Guilong Kechuanning tablets at present.

The invention discloses a preparation process of Guilong Kechuanning tablets, which is applied to the fields of application numbers 201610743233.X, application number 2016.08.28 and the like in China.

The invention discloses an analysis method of Guilong Kechuanning tablets, which is disclosed by the Chinese patent of the invention, the patent number CN200910148338.0, application No. 2009.06.16.

The invention discloses a nano Guilong Kechuanning preparation medicine and a preparation method thereof, application No. CN01100113.5, application No. 2001.01.05, and discloses a technical scheme of a nano Guilong Kechuanning preparation medicine and a preparation method thereof.

And the national food and drug administration headquarters drug standard YBZ19442005-2014Z-1 also discloses related prescriptions.

Disclosure of Invention

In order to solve the technical problems, the invention aims to provide a preparation process of Guilong Kechuanning tablets,

the technical scheme adopted by the invention is as follows:

the preparation method of the Guilong Kechuanning tablet is characterized by comprising the following components in parts by weight: 8.6% of cassia twig, 17.2% of dragon bone, 8.6% of white peony root, 8.6% of ginger, 8.6% of Chinese date, 5.2% of honey-fried licorice root, 17.2% of oyster, 1.8% of coptis root, 7.8% of rhizoma pinellinae praeparata, 8.6% of trichosanthes peel and 7.8% of bitter almond (fried); a proper amount of water;

the preparation method comprises the following steps:

firstly, pretreatment and weighing for later use: the components are pretreated for standby;

1. cassia twig:

picking: removing impurities;

cleaning: cleaning with flowing drinking water until the medicinal materials are free of sludge and the water quality is clear, so that the medicinal materials are clean and thoroughly moistened;

cutting: cutting the thoroughly moistened medicinal materials into thick pieces (2-4 mm) for later use;

and fourthly, drying: cutting the medicinal materials, and drying:

primary drying: placing the cut medicinal materials in a hot air circulation oven for oven drying for 1 hour, and controlling the drying temperature to be 70-80 ℃; then naturally cooling to normal temperature;

secondary drying: drying the cassia twig subjected to primary drying in a vacuum drying oven for 1 hour under reduced pressure, wherein the drying temperature is controlled to be 50-60 ℃; the vacuum degree is-0.9 mPa-0.8 mPa; then naturally cooling to normal temperature;

and (3) drying for the third time: drying the secondarily dried cassia twig in a freeze dryer for 1 hour at the drying temperature of 0-5 ℃; naturally cooling to normal temperature; standby;

crushing: pulverizing the cassia twig decoction pieces into fine powder for later use;

sixthly, sterilization: sterilizing the fine powder of ramulus Cinnamomi in vacuum sterilizing cabinet at 115 deg.C for 30 min, and taking out;

2. keel: taking qualified medicinal materials, screening out impurities, washing with water, and feeding;

picking: removing impurities;

cleaning: cleaning with flowing drinking water until the medicinal materials are free of sludge and the water quality is clear, so that the medicinal materials are clean;

smashing the blocks: smashing the medicinal materials into small pieces (8-12 mm) for later use;

3. white peony root:

picking: removing impurities;

and fourthly, drying: cutting the medicinal materials, and drying part of the medicinal materials:

1. primary drying: drying in a hot air circulation oven for 1 hr at a temperature below 80 deg.C;

2. secondary drying: drying in a vacuum freeze dryer for 1 hour at 0-5 deg.C; naturally cooling to normal temperature; standby;

crushing: pulverizing radix Paeoniae alba decoction pieces into fine powder, and weighing;

sixthly, sterilization: sterilizing the fine powder of radix Paeoniae alba in a vacuum sterilizing cabinet at 115 deg.C for 30 min, and taking out;

4. ginger:

picking: removing impurities;

5. chinese date:

picking: removing impurities;

cutting: breaking the medicinal materials for use;

6. honey-fried licorice root:

picking: removing impurities;

cleaning: cleaning with flowing drinking water, and moistening;

cutting: cutting the thoroughly moistened medicinal materials into thick pieces (2-4 mm);

and fourthly, drying: cutting the medicinal materials, drying in a hot air circulation oven at a temperature below 80 deg.C;

fifthly, radix glycyrrhizae preparata: weighing clean liquorice tablets, adding honey accounting for 25 percent of the medicinal material, and processing for later use;

7. oyster shell:

drying: drying the medicinal materials in a hot air circulation oven at a temperature below 80 deg.C;

③ grinding: grinding and crushing the medicinal materials for later use;

8. coptis chinensis:

picking: removing impurities;

cleaning: washing with water until the mixture is thoroughly moistened;

cutting: cutting the thoroughly moistened medicinal materials into slices (1-2 mm) for later use;

9. rhizoma pinelliae preparata:

cleaning and selecting;

cutting the decoction pieces;

thirdly, frying for later use;

10. pericarpium trichosanthis:

cleaning: washing with water, and slightly drying;

cutting: cutting the thoroughly moistened medicinal materials into wide threads (5-10 mm) for later use;

11. frying bitter almonds:

picking: removing impurities;

cleaning: washing with water;

thirdly, drying: drying clean medicinal materials in a hot air circulation oven at a temperature below 60 deg.C; standby;

stir-frying bitter apricot seeds: weighing bitter apricot seeds, processing and weighing for later use;

grinding: grinding and crushing the medicinal materials for later use;

secondly, powdering: pulverizing ramulus Cinnamomi and radix Paeoniae alba 48.8 wt% into fine powder, sieving with 80 mesh sieve, and mixing;

thirdly, extraction:

putting the keel, the white paeony root, the ginger, the Chinese date, the honey-fried licorice root, the oyster, the coptis chinensis, the rhizoma pinellinae praeparata, the pericarpium trichosanthis and the bitter apricot kernel (fried) decoction pieces in parts by weight into a multifunctional extraction tank, adding 8 times of water, soaking for 1-2 hours, decocting for 2 hours, boiling for a specified time, closing steam, extracting liquid medicine, filtering by using a 200-mesh sieve to obtain primary filtrate for later use, and taking residual medicine dregs in the multifunctional extraction tank as a primary processing raw material;

adding 6 times of water into the primary processed raw material obtained by processing for the second time, decocting for 1 hour, turning off steam after the specified time, extracting liquid medicine, and filtering by a 200-mesh sieve to obtain secondary filtrate for later use; the residual dregs in the multifunctional extraction tank are used as the secondary processing raw material;

thirdly, adding 6 times of water into the secondary processing raw materials obtained by processing in the second step, decocting for 30 minutes, turning off steam after boiling for a specified time, extracting liquid medicine, filtering by a 200-mesh sieve to obtain third filtrate for later use, and using the residual dregs in the multifunctional extraction tank as fuel or fertilizer for farmers;

fourthly, combining the primary filtrate, the secondary filtrate and the tertiary filtrate to be used as water extraction liquid medicine, and placing the liquid medicine in a liquid storage tank for standby;

in the processing steps, the steam pressure of an extraction tank is 0.1-0.2 Mpa, and the pressure in the extraction tank is 0.05 Mpa;

fourthly, concentration:

fourthly, the water extraction liquid medicine for standby in the liquid storage tank in the third step enters the I-effect evaporator and the II-effect evaporator in the double-effect concentrator from the liquid storage tank until the sight glass 2/3 stops, the heating is carried out under the condition that the steam pressure is preferably 0.1Mpa, and the material is supplemented to the normal liquid level in time;

secondly, in order to maintain a higher heat transfer coefficient, the I-effect evaporator and the II-effect evaporator discharge condensed water once in 15 minutes and discharge condensed steam of the heater once every two hours;

③ after the feed liquid is concentrated to a certain concentration, the feed liquid in the II-effect evaporator is transferred into the I-effect evaporator to be merged and concentrated, and the discharge (namely the paste collection) is carried out according to the process requirement of the paste concentration to obtain the relative density of 1.25 to 1.28 (measured at 60 ℃) kg/m³The paste with the solid content of 46 to 51 percent is sieved by a 100-mesh sieve to obtain clear paste for later use;

in the steps, the steam pressure of the double-effect concentrator is 0.1-0.2 Mpa; the vacuum degree is-0.03 to-0.04 Mpa for the I effect and-0.06 to-0.08 Mpa for the II effect;

fifthly, preparation:

the components used were: fluid extract, cassia twig fine powder, white paeony root fine powder, starch, povidone K30 and magnesium stearate;

proportioning: weighing 47.6 percent of clear paste of the Guilong Kechuanning tablet, 21.5 percent of fine powder of cassia twig, 10.5 percent of fine powder of white paeony root, 19 percent of starch, 1 percent of polyvidone K30 and the like in sequence according to the following weight components for later use;

② the cassia twig fine powder, the white paeony root fine powder, the starch and the povidone K30 are put into a mixer and dry-mixed for 15 minutes;

preparing soft materials: after the materials are dry-mixed for 15 minutes, the clear paste is uniformly added under stirring, and the soft materials prepared by continuously stirring for 10 minutes have uniform and consistent color and luster;

preparing wet particles: placing the soft material in a swing type granulation machine, and preparing into wet granules by using a 16-mesh nylon sieve;

drying: drying the wet granules in a high-efficiency boiling dryer, gradually raising the temperature, controlling the drying temperature to be 55-60 ℃, controlling the moisture to be 2.0-5.0%, taking out, and cooling;

sixthly, straightening the grains: placing the prepared particles in a swing type granulator, and granulating by using a 16-mesh nylon sieve (treating coarse particles as tailings);

and (c) mixing: adding magnesium stearate, mixing for 25 min, and mixing; then placing the mixture in a clean container;

eighthly, tabletting: formally tabletting the mixture by a tabletting machine; the obtained tablet is ready for use;

ninthly, coating: coating the tablets in the eight Chinese medicinal herbs by using a high-efficiency coating machine, then transferring the coated film-coated tablets into a clean and dry cloth bag, and transferring the cloth bag into a coating and drying chamber for drying for 14 to 20 hours; standby;

and (3) subpackaging in the R: the sub-packaging machine carries out sub-packaging on the tablet subjected to the ninthly treatment by using an inner packaging material;

packaging: carrying out outer packaging on the tablets subjected to the wave front processing by using an automatic packaging machine;

warehousing: and putting the packaged tablets into a warehouse for sale.

The relative density of the clear paste is 1.28(60 ℃) kg/m³The solid content of the clear paste is 51 percent.

The relative density of the clear paste is 1.27(60 ℃) kg/m³The solid content of the clear paste is 50 percent.

the preparation method comprises the following steps:

1. cassia twig:

picking: removing impurities;

and fourthly, drying: cutting the medicinal materials, and drying:

primary drying: placing the cut medicinal materials in a hot air circulation oven for oven drying for 1 hour, and controlling the drying temperature at 75 ℃; then naturally cooling to normal temperature;

secondary drying: drying ramulus Cinnamomi dried once in vacuum oven under reduced pressure for 1 hr, and controlling drying temperature at 55 deg.C; the vacuum degree is-0.9 mPa-0.8 mPa; then naturally cooling to normal temperature;

and (3) drying for the third time: drying the secondarily dried cassia twig in a freeze dryer for 1 hour, wherein the drying temperature is controlled at 0 ℃; naturally cooling to normal temperature; standby;

picking: removing impurities;

3. white peony root:

picking: removing impurities;

1. primary drying: drying in a hot air circulation oven for 1 hr at temperature below 75 deg.C;

2. secondary drying: drying in a vacuum freeze dryer for 1 hr at 1 deg.C; naturally cooling to normal temperature; standby;

4. ginger:

picking: removing impurities;

5. chinese date:

picking: removing impurities;

cutting: breaking the medicinal materials for use;

6. honey-fried licorice root:

picking: removing impurities;

cleaning: cleaning with flowing drinking water, and moistening;

7. oyster shell:

③ grinding: grinding and crushing the medicinal materials for later use;

8. coptis chinensis:

picking: removing impurities;

cleaning: washing with water until the mixture is thoroughly moistened;

9. rhizoma pinelliae preparata:

cleaning and selecting;

cutting the decoction pieces;

thirdly, frying for later use;

10. pericarpium trichosanthis:

cleaning: washing with water, and slightly drying;

11. frying bitter almonds:

picking: removing impurities;

cleaning: washing with water;

grinding: grinding and crushing the medicinal materials for later use;

thirdly, extraction:

fourthly, concentration:

firstly, the water extraction liquid medicine for standby in the liquid storage tank in the third step enters the I-effect evaporator and the II-effect evaporator in the double-effect concentrator from the liquid storage tank until the time of observing the sight glass 2/3, the heating is carried out under the condition that the steam pressure is 0.1Mpa, and the material is supplemented to the normal liquid level in time;

③ after the feed liquid is concentrated to a certain concentration, the feed liquid in the II-effect evaporator is transferred into the I-effect evaporator to be merged and concentrated, and the discharge (namely the paste collection) is carried out according to the process requirement of the paste concentration to obtain the relative density of 1.26 (at 60 ℃) kg/m³Sieving solid substance of paste 48% with 100 mesh sieve to obtain fluid extract;

fifthly, preparation:

sixthly, packaging: carrying out outer packaging on the tablets subjected to the wave front processing by using an automatic packaging machine;

warehousing: and putting the packaged tablets into a warehouse for sale.

The invention has the beneficial effects that: the pretreatment of the components, particularly the cassia twig and the white paeony root, is carried out, and the three times of drying is carried out on the pretreatment of the cassia twig, so that the medicinal material is dried uniformly inside and outside, is loose and porous, is easy to crush, and is more convenient to manufacture; the white paeony root is dried for a plurality of times, so that the medicinal materials are easier to crush, therefore, the preparation of the medicine is improved through the improvement of the process, and the white paeony root medicinal powder has good popularization value.

Drawings

FIG. 1 is a flow chart of the manufacturing process of the present invention

FIG. 2 is a flow chart of the addition process of each component

FIG. 3 is a process flow diagram of the formulation

Detailed Description

Cassia twig, name of traditional Chinese medicine. Belonging to Camphor order, Lauraceae family, middle arbors; the annual branch is cylindrical, the terminal bud scales are wide and oval, green leaves grow mutually, and the annual branch is oblong to be nearly acicular; flower white, about 4.5mm long; oval fruit, black purple at maturity, hairless; the flowering period is 6-8 months, and the fruit period is 10-12 months. Mainly produced in Guangxi, Guangdong and Yunnan provinces. Cutting off twig in spring and summer, drying in the sun or in the shade, and cutting into slices or small sections. Pungent, sweet and warm. It enters heart, lung and bladder meridians. Has effects of inducing sweat, expelling pathogenic factors from muscles, warming and dredging channels, supporting yang, regulating qi, and lowering qi. It is commonly used for wind-cold type common cold, abdominal cold pain, amenorrhea due to blood cold, arthralgia, phlegm and fluid retention, edema, palpitation, etc.; it is combined with Bai Shao for wind-cold, exterior deficiency with sweating.

Dragon bone, name of Chinese medicine. Is skeleton fossil of ancient mammal elephant, rhinoceros, three-toe horse, cattle, deer, etc. Consists of Apatite Apatite, Calcite Calcite and a small amount of clay minerals. Produced in inner Mongolia, Hebei, Shanxi, Gansu, Henan, Hubei, Sichuan and other places. Has the effects of calming the heart, soothing the nerves, calming the liver, suppressing yang hyperactivity, inducing astringency and astringing. It is commonly used for palpitation, insomnia, amnesia, fright epilepsy, mania, dizziness, night sweat, spermatorrhea, enuresis, metrorrhagia, leukorrhagia, chronic diarrhea, chronic dysentery, ulcer, and eczema.

White peony root, name of traditional Chinese medicine. Is dried root of Paeonia lactiflora pall. of Ranunculaceae. Collected in summer and autumn, cleaned, removed head, tail and fine root, boiled in boiling water, peeled or boiled again, and dried in the sun. Has the functions of nourishing blood, regulating menstruation, astringing yin, arresting sweating, softening liver, relieving pain and suppressing liver yang. It is commonly used for blood deficiency and chlorosis, irregular menstruation, spontaneous perspiration, night sweat, hypochondriac pain, abdominal pain, limb spasm and pain, headache and vertigo.

Fresh ginger, named as traditional Chinese medicine. Is fresh rhizome of Zingiber officinale Roscoe of Zingiberaceae, and is also named as rhizoma Zingiberis recens root, BAIYANYUN, collutory finger, DIXIN, YANLIANGZI, and fresh rhizoma Zingiberis recens. The rhizome (dried ginger), the bark (ginger peel) and the leaf (ginger leaf) of Zingiber officinale can be used as the raw materials. Ginger is pungent in flavor and slightly warm in nature. It enters lung, spleen and stomach meridians. Has effects of relieving exterior syndrome, dispelling cold, warming spleen and stomach, relieving vomit, warming lung, relieving cough, and removing toxic substance, and can be used for treating wind-cold type common cold, spleen and stomach cold syndrome, stomach cold type emesis, lung cold type cough, and fish and crab toxin.

Jujube, name of Chinese medicinal material. The product is mature fruit of Zizyphi fructus of Rhamnaceae. Collected in autumn when the fruit is ripe. Impurities are removed and dried in the sun. Or baking to soft skin, and sun drying. Or boiling with water, taking out when the pulp is soft and the skin is not shrunk, and drying in the sun. The main functional indications are as follows: invigorating spleen and regulating stomach function, benefiting qi and promoting fluid production, regulating yingfen and weifen, and removing drug toxicity. It is indicated for deficiency of stomach and food, spleen weakness, loose stool, qi, blood and body fluids deficiency, disharmony between ying and wei, palpitation. The women are dirty and manic.

Taking radix Glycyrrhizae Preparata, parching with honey until it is yellow to dark yellow, taking out when it is not sticky, and cooling; warm in nature and sweet in taste. They enter heart, lung, stomach and spleen meridians. Tonify spleen and stomach, replenish qi and recover pulse. They belong to qi tonics classified under deficiency tonics.

Oyster shell, name of Chinese medicinal material. The product is the shell of Ostrea gigas Thunb, Ostrea gigas Thunb or Ostrea gigas Thunb of Ostreidae. Collected all year round. After the product is obtained, the meat is removed, the shell is taken out, cleaned and dried in the sun. The main functional indications are as follows: astringe yin, subdue yang, check sweating, astringe essence, resolve phlegm and soften hard masses. It is indicated for fright epilepsy, vertigo, spontaneous perspiration, night sweat, seminal emission, stranguria with turbid urine, metrorrhagia, leukorrhagia, scrofula and goiter. Can be used for treating palpitation, insomnia, vertigo, tinnitus, scrofula, subcutaneous nodule, lump in the abdomen, spontaneous perspiration, night sweat, nocturnal emission, metrorrhagia, gastralgia, and pantothenic acid. Calcined oyster shell astringes and astringes. Can be used for treating spontaneous perspiration, night sweat, spermatorrhea, metrorrhagia, gastralgia, and acid regurgitation.

Coptis root, Chinese medicine name. Alias: coptis chinensis Franch, Coptis chinensis Franch and Coptis chinensis Franch of Ranunculaceae, which are perennial herb plants of Coptis, are based and confounded in leaves, are hard and paper, are in an oval triangle shape, are full-cracked, are in an oval rhombus shape with a central lobe, are deep-cracked in a pinnate shape, have sharp sawteeth on the edge, and have 2 deep-cracked lateral lobes; the petiole is 5-300px long. Wild or cultivated in valley cool and wet shading forest with elevation of 1000-1900 m. Has the effects of clearing heat, eliminating dampness, purging fire and removing toxicity.

Rhizoma pinellinae praeparata, rhizoma pinellinae praeparata and Chinese medicinal material names. The product is processed product of rhizoma Pinelliae. The main functional indications are as follows: dry dampness and resolve phlegm. Can be used for treating cough and asthma due to excessive phlegm, dizziness and palpitation due to phlegm and fluid retention, dizziness due to wind-phlegm, phlegm syncope and headache.

Pericarpium trichosanthis, name of Chinese medicinal material. The product is dried mature pericarp of Trichosanthes kirilowii Maxim, Cucurbitaceae, or Trichosanthes rosthornii Harms. Picking mature fruits in autumn, cutting open, removing pulp and seeds, and drying in the shade. The main functional indications are as follows: clear and resolve heat-phlegm, promote qi circulation and relieve chest stuffiness. Can be used for treating cough due to phlegm-heat, chest distress, and hypochondriac pain.

Bitter apricot seed (fried), named as Chinese medicinal material. Warm in nature and bitter in taste; has little toxicity. It enters lung and large intestine meridians. The product is seed of Prunus Armeniaca L of Rosaceae. Collecting mature fruits in summer, removing pulp and nucleocapsid, taking seeds, and drying in the sun. The main functional indications are as follows: direct qi downward to relieve cough and dyspnea, moisten intestines to relieve constipation.

The role starch can play in tablets is: diluent, absorbent, disintegrating agent and adhesive

Since the povidone k30 has the characteristics of dissolution aiding, film forming, adhesion, thickening, dispersion and the like, the povidone k30 plays an important role in medicines such as tablets, capsules, injections, even eye drops and the like, has extremely wide application and is an important pharmaceutic adjuvant.

Magnesium stearate is an auxiliary material added in pharmacy, is mainly used for lubrication, anti-adhesion and flow aid, is beneficial to fully mixing medicinal components and keeps a certain shape.

The invention is explained in detail below with reference to fig. 1 to 3:

example 1:

the preparation method of the Guilong Kechuanning tablet comprises the following components by weight: 8.6% of cassia twig, 17.2% of dragon bone, 8.6% of white peony root, 8.6% of ginger, 8.6% of Chinese date, 5.2% of honey-fried licorice root, 17.2% of oyster, 1.8% of coptis root, 7.8% of rhizoma pinellinae praeparata, 8.6% of trichosanthes peel and 7.8% of bitter almond (fried); a proper amount of water;

the preparation method comprises the following steps:

1. cassia twig:

picking: removing impurities;

and fourthly, drying: cutting the medicinal materials, and drying:

the cassia twig is pretreated and dried for three times, so that the medicinal materials are loose, porous and easy to crush, and the preparation is more convenient; the cassia twig is directly and commonly dried and is normally dried or dried at the temperature of below 80 ℃, and the direct bad effect is that the internal and external drying is uneven, so that the drug effect is reduced and even the deterioration occurs;

crushing: pulverizing the cassia twig decoction pieces into fine powder for later use; because the processing steps in the fourth step are in place, the crushed cassia twig powder is yellow brown to brown powder, has special fragrance, sweet taste and slight pungent taste. The fineness of the microbial inoculum is that the microbial inoculum completely passes through an 80-mesh sieve and can pass through a 100-mesh sieve by not less than 95 percent, and the limit of the microbes is that the total number of aerobic bacteria is not more than 8000 cfu/g; the total number of the mould and the microzyme is less than or equal to 100 cfu/g; escherichia coli cannot be detected every 1 g; no salmonella can be detected every 10 g; every 1g of the gram-negative bacteria resistant to the cholate should be less than 100 cfu/g;

picking: removing impurities;

3. white peony root:

picking: removing impurities;

the radix paeoniae alba is dried for many times, so that the medicinal materials are easier to crush, and are easier to extract and prepare. The primary drying in the hot air circulation drying oven is mainly to remove partial moisture, and the secondary drying in the vacuum freeze dryer is mainly to ensure that the medicinal materials have low moisture and high quality fraction, are loose and porous, and are convenient for the next treatment.

Crushing: pulverizing radix Paeoniae alba decoction pieces into fine powder, and weighing; because the processing steps in the fourth step are in place, the crushed white paeony root is yellowish white powder, slight smell, slightly bitter and sour taste and no foreign matters. The fineness index can pass through 80 meshes and can pass through not less than 95 percent of 100 meshes. The limit of the microorganisms is that the total number of aerobic bacteria is less than or equal to 8000 cfu/g; the total number of the mould and the microzyme is less than or equal to 100 cfu/g; escherichia coli cannot be detected every 1 g; no salmonella can be detected every 10 g; every 1g of the gram-negative bacteria with cholate resistance is less than 100 cfu/g.

4. ginger:

picking: removing impurities;

5. chinese date:

picking: removing impurities;

cutting: breaking the medicinal materials for use;

6. honey-fried licorice root:

picking: removing impurities;

cleaning: cleaning with flowing drinking water, and moistening;

7. oyster shell:

③ grinding: grinding and crushing the medicinal materials for later use;

8. coptis chinensis:

picking: removing impurities;

cleaning: washing with water until the mixture is thoroughly moistened;

9. rhizoma pinelliae preparata:

cleaning and selecting;

cutting the decoction pieces;

thirdly, frying for later use;

10. pericarpium trichosanthis:

cleaning: washing with water, and slightly drying;

11. frying bitter almonds:

picking: removing impurities;

cleaning: washing with water;

grinding: grinding and crushing the medicinal materials for later use;

secondly, powdering: pulverizing ramulus Cinnamomi and radix Paeoniae alba 48.8 wt% into fine powder, sieving with 80 mesh sieve, and mixing; thirdly, extraction:

fourthly, concentration:

fifthly, preparation:

warehousing: and putting the packaged tablets into a warehouse for sale.

Compared with the clear paste prepared by the traditional process, the method has the advantages that the process steps are optimized, and the improvement is not small.

Example 2:

the quality of the components is the same as that of the component in the embodiment 1, when the steam pressure of the double-effect concentrator is 0.16 Mpa; the relative density of the obtained fluid extract is 1.28(60 deg.C) kg/m when the vacuum degree is-0.038 Mpa (I effect) and-0.068 Mpa (II effect)³The solid content of the clear paste is 51 percent.

Example (b): 3:

the quality of the components is the same as that of the components in the embodiment 1, when the steam pressure of the double-effect concentrator is 0.15 Mpa; when the vacuum degree is I effect-0.036 Mpa and II effect-0.068 Mpa, the relative density of the fluid extract is 1.27(60 deg.C) kg/m³The solid content of the clear paste is 50 percent.

Example 4:

the following components by weight are adopted: 8.6% of cassia twig, 17.2% of dragon bone, 8.6% of white peony root, 8.6% of ginger, 8.6% of Chinese date, 5.2% of honey-fried licorice root, 17.2% of oyster, 1.8% of coptis root, 7.8% of rhizoma pinellinae praeparata, 8.6% of trichosanthes peel and 7.8% of bitter almond (fried); a proper amount of water;

the preparation method comprises the following steps:

1. cassia twig:

picking: removing impurities;

and fourthly, drying: cutting the medicinal materials, and drying:

picking: removing impurities;

3. white peony root:

picking: removing impurities;

4. ginger:

picking: removing impurities;

5. chinese date:

picking: removing impurities;

cutting: breaking the medicinal materials for use;

6. honey-fried licorice root:

picking: removing impurities;

cleaning: cleaning with flowing drinking water, and moistening;

7. oyster shell:

③ grinding: grinding and crushing the medicinal materials for later use;

8. coptis chinensis:

picking: removing impurities;

cleaning: washing with water until the mixture is thoroughly moistened;

9. rhizoma pinelliae preparata:

cleaning and selecting;

cutting the decoction pieces;

thirdly, frying for later use;

10. pericarpium trichosanthis:

cleaning: washing with water, and slightly drying;

11. frying bitter almonds:

picking: removing impurities; cleaning: washing with water; thirdly, drying: drying clean medicinal materials in a hot air circulation oven at a temperature below 60 deg.C; standby; stir-frying bitter apricot seeds: weighing bitter apricot seeds, processing and weighing for later use; grinding: grinding and crushing the medicinal materials for later use;

thirdly, extraction: putting the keel, the white paeony root, the ginger, the Chinese date, the honey-fried licorice root, the oyster, the coptis chinensis, the rhizoma pinellinae praeparata, the pericarpium trichosanthis and the bitter apricot kernel (fried) decoction pieces in parts by weight into a multifunctional extraction tank, adding 8 times of water, soaking for 1-2 hours, decocting for 2 hours, boiling for a specified time, closing steam, extracting liquid medicine, filtering by using a 200-mesh sieve to obtain primary filtrate for later use, and taking residual medicine dregs in the multifunctional extraction tank as a primary processing raw material; adding 6 times of water into the primary processed raw material obtained by processing for the second time, decocting for 1 hour, turning off steam after the specified time, extracting liquid medicine, and filtering by a 200-mesh sieve to obtain secondary filtrate for later use; the residual dregs in the multifunctional extraction tank are used as the secondary processing raw material; thirdly, adding 6 times of water into the secondary processing raw materials obtained by processing in the second step, decocting for 30 minutes, turning off steam after boiling for a specified time, extracting liquid medicine, filtering by a 200-mesh sieve to obtain third filtrate for later use, and using the residual dregs in the multifunctional extraction tank as fuel or fertilizer for farmers; fourthly, combining the primary filtrate, the secondary filtrate and the tertiary filtrate to be used as water extraction liquid medicine, and placing the liquid medicine in a liquid storage tank for standby; in the processing steps, the steam pressure of an extraction tank is 0.1-0.2 Mpa, and the pressure in the extraction tank is 0.05 Mpa;

fourthly, concentration: firstly, the water extraction liquid medicine for standby in the liquid storage tank in the third step enters the I-effect evaporator and the II-effect evaporator in the double-effect concentrator from the liquid storage tank until the time of observing the sight glass 2/3, the heating is carried out under the condition that the steam pressure is 0.1Mpa, and the material is supplemented to the normal liquid level in time; secondly, in order to maintain a higher heat transfer coefficient, the I-effect evaporator and the II-effect evaporator discharge condensed water once in 15 minutes and discharge condensed steam of the heater once every two hours; ③ after the feed liquid is concentrated to a certain concentration, the feed liquid in the II-effect evaporator is transferred into the I-effect evaporator to be merged and concentrated, and the discharge (namely the paste collection) is carried out according to the process requirement of the paste concentration to obtain the relative density of 1.26 (at 60 ℃) kg/m³Sieving solid substance of paste 48% with 100 mesh sieve to obtain fluid extract; in the steps, the steam pressure of the double-effect concentrator is 0.1-0.2 Mpa; the vacuum degree is-0.03 to-0.04 Mpa for the I effect and-0.06 to-0.08 Mpa for the II effect; fifthly, preparation:

proportioning: weighing 47.6 percent of clear paste of the Guilong Kechuanning tablet, 21.5 percent of fine powder of cassia twig, 10.5 percent of fine powder of white paeony root, 19 percent of starch, 1 percent of polyvidone K30 and the like in sequence according to the following weight components for later use; ② the cassia twig fine powder, the white paeony root fine powder, the starch and the povidone K30 are put into a mixer and dry-mixed for 15 minutes; preparing soft materials: after the materials are dry-mixed for 15 minutes, the clear paste is uniformly added under stirring, and the soft materials prepared by continuously stirring for 10 minutes have uniform and consistent color and luster; preparing wet particles: placing the soft material in a swing type granulation machine, and preparing into wet granules by using a 16-mesh nylon sieve; drying: drying the wet granules in a high-efficiency boiling dryer, gradually raising the temperature, controlling the drying temperature to be 55-60 ℃, controlling the moisture to be 2.0-5.0%, taking out, and cooling; sixthly, straightening the grains: placing the prepared particles in a swing type granulator, and granulating by using a 16-mesh nylon sieve (treating coarse particles as tailings); and (c) mixing: adding magnesium stearate, mixing for 25 min, and mixing; then placing the mixture in a clean container;eighthly, tabletting: formally tabletting the mixture by a tabletting machine; the obtained tablet is ready for use; ninthly, coating: coating the tablets in the eight Chinese medicinal herbs by using a high-efficiency coating machine, then transferring the coated film-coated tablets into a clean and dry cloth bag, and transferring the cloth bag into a coating and drying chamber for drying for 14 to 20 hours; standby; and (3) subpackaging in the R: the sub-packaging machine carries out sub-packaging on the tablet subjected to the ninthly treatment by using an inner packaging material;

warehousing: and putting the packaged tablets into a warehouse for sale.

The method of the invention produces the Guilong Kechuanning tablets with high quality and better market popularization value after multiple trial production of the testing machine.

Claims

1. The preparation method of the Guilong Kechuanning tablet is characterized by comprising the following components in parts by weight: 8.6% of cassia twig, 17.2% of dragon bone, 8.6% of white peony root, 8.6% of ginger, 8.6% of Chinese date, 5.2% of honey-fried licorice root, 17.2% of oyster, 1.8% of coptis root, 7.8% of rhizoma pinellinae praeparata, 8.6% of trichosanthes peel and 7.8% of bitter almond (fried); a proper amount of water;

the preparation method comprises the following steps:

1. cassia twig:

picking: removing impurities;

and fourthly, drying: cutting the medicinal materials, and drying:

picking: removing impurities;

3. white peony root:

picking: removing impurities;

4. ginger:

picking: removing impurities;

5. chinese date:

picking: removing impurities;

cutting: breaking the medicinal materials for use;

6. honey-fried licorice root:

picking: removing impurities;

cleaning: cleaning with flowing drinking water, and moistening;

7. oyster shell:

③ grinding: grinding and crushing the medicinal materials for later use;

8. coptis chinensis:

picking: removing impurities;

cleaning: washing with water until the mixture is thoroughly moistened;

9. rhizoma pinelliae preparata:

cleaning and selecting;

cutting the decoction pieces;

thirdly, frying for later use;

10. pericarpium trichosanthis:

cleaning: washing with water, and slightly drying;

11. frying bitter almonds:

picking: removing impurities;

cleaning: washing with water;

grinding: grinding and crushing the medicinal materials for later use;

thirdly, extraction:

fourthly, concentration:

fifthly, preparation:

warehousing: and putting the packaged tablets into a warehouse for sale.

2. The method for preparing Guilong Kechuanning tablet according to claim 1, wherein the relative density of the clear paste is 1.28(60 ℃) kg/m³The solid content of the clear paste is 51 percent.

3. The method for preparing Guilong Kechuanning tablet according to claim 1, wherein the relative density of the clear paste is 1.27(60 ℃) kg/m³The solid content of the clear paste is 50 percent.

4. The preparation method of the Guilong Kechuanning tablet is characterized by comprising the following components in parts by weight: 8.6% of cassia twig, 17.2% of dragon bone, 8.6% of white peony root, 8.6% of ginger, 8.6% of Chinese date, 5.2% of honey-fried licorice root, 17.2% of oyster, 1.8% of coptis root, 7.8% of rhizoma pinellinae praeparata, 8.6% of trichosanthes peel and 7.8% of bitter almond (fried); a proper amount of water;

the preparation method comprises the following steps:

1. cassia twig:

picking: removing impurities;

and fourthly, drying: cutting the medicinal materials, and drying:

picking: removing impurities;

3. white peony root:

picking: removing impurities;

4. ginger:

picking: removing impurities;

5. chinese date:

picking: removing impurities;

cutting: breaking the medicinal materials for use;

6. honey-fried licorice root:

picking: removing impurities;

cleaning: cleaning with flowing drinking water, and moistening;

7. oyster shell:

③ grinding: grinding and crushing the medicinal materials for later use;

8. coptis chinensis:

picking: removing impurities;

cleaning: washing with water until the mixture is thoroughly moistened;

9. rhizoma pinelliae preparata:

cleaning and selecting;

cutting the decoction pieces;

thirdly, frying for later use;

10. pericarpium trichosanthis:

cleaning: washing with water, and slightly drying;

11. frying bitter almonds:

picking: removing impurities;

cleaning: washing with water;

grinding: grinding and crushing the medicinal materials for later use;

thirdly, extraction:

fourthly, concentration:

fifthly, preparation:

warehousing: and putting the packaged tablets into a warehouse for sale.