CN115120513A - MXene anti-aging and anti-oxidation skin care product and preparation method thereof - Google Patents
MXene anti-aging and anti-oxidation skin care product and preparation method thereof Download PDFInfo
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- CN115120513A CN115120513A CN202110329965.5A CN202110329965A CN115120513A CN 115120513 A CN115120513 A CN 115120513A CN 202110329965 A CN202110329965 A CN 202110329965A CN 115120513 A CN115120513 A CN 115120513A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Public Health (AREA)
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- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
Abstract
The invention provides an MXene anti-aging and anti-oxidation skin care product and a preparation method thereof. The research of the invention finds that MXene can generate Fenton-like reaction and reduce the generation of Reactive Oxygen Species (ROS). Provides a new way for researching and developing novel antioxidant products. The invention applies MXene to the skin care product for the first time, and is the re-expansion of the application field of MXene. After MXene is used as an additive, the MXene can effectively remove excessive oxygen radicals in human skin, improve the effects of skin aging resistance, oxidation resistance, beauty and skin care products, has the effects of whitening, inhibiting bacteria, diminishing inflammation, removing acnes and the like, and can be widely used in most of products needing oxidation resistance, such as daily chemical products and the like.
Description
Technical Field
The invention relates to the technical field of skin care products, in particular to an MXene anti-aging and anti-oxidation skin care product and a preparation method thereof.
Background
The skin of the human body is continuously contacted with the outside, ultraviolet rays, radiation and air pollution are continuously infiltrated, free radicals are generated, collagen and elastic fibers of the skin are damaged, wrinkles are generated, and pigmentation and the like are caused. Skin aging is mainly started from the attack of free radicals on healthy cells, and for a long time, the symptoms of cell continuous damage, skin elasticity loss, dark skin color and the like can be caused. Although there are many anti-aging products on the market, the raw materials used are commonly used, such as antioxidant raw materials like nicotinamide, ascorbic acid, astaxanthin and the like, and the compounding of different skin care components is selected, and the compounding of different skin care components is an additive effect under general conditions, so that the skin care product has little real synergistic effect, and particularly has obvious synergistic effect. How to achieve zero addition and no allergy of the product, and the effect and nutrition combination has the extreme effects of soothing and nourishing the skin, repairing and resisting aging of the face skin, is a problem to be solved urgently in the research of the current MXene anti-aging anti-oxidation beauty and skin care cosmetic. Fenton-like effect of MXene materials, especially Ti 3 C 2 In the presence of Ti 3+ Such a reaction may occur: ti 3+ +H 2 O 2 =Ti 4+ +(OH) - +OH; Ti 4+ +H 2 O 2 +4H 2 O=H 2 TiO 4 +4H + It is equivalent to the action of catalase and is used for eliminating free radicals. Anti-oxidation is a process that acts directly on free radicals or indirectly consumes substances that readily generate free radicals, preventing further reactions from occurring. Therefore, anti-aging and anti-oxidation products are just needed in the current market.
Disclosure of Invention
The invention aims to provide an MXene anti-aging and anti-oxidation skin care product, and experimental researches of the invention find that MXene can not only remove free radicals and resist skin aging through a Fenton-like reaction, but also has the function of eliminating the free radicals and generating Ti due to the fact that MXene is equivalent to catalase 3+ +H 2 O 2 =Ti 4+ +(OH) - +OH; Ti 4+ +H 2 O 2 +4H 2 O=H 2 TiO 4 +4H + The experimental results show that MXeneThe material has the function of eliminating active oxygen, namely resisting oxidation. Cell experiments show that MXene can kill deep bacteria by physically inserting and contacting MXene to destroy a biofilm structure, the sterilization effect of the TiVC on escherichia coli can reach 100%, and the effects of absorbing grease and preserving moisture are achieved, and the effects are not achieved by similar cosmetics.
In order to realize the purpose of the invention, the invention adopts the following technical scheme:
the MXene anti-aging and anti-oxidation skin care product is characterized by comprising the following components:
(A)5-25 wt% of an anti-aging and anti-oxidant nutritional composition;
(B) optionally, 95-75 wt% of ingredients commonly used in skin care cosmetics;
wherein the percentage contents are calculated based on the total weight of the cosmetic;
preferably, the anti-aging and anti-oxidation nutritional composition comprises: MXene, chitosan amine, nicotinamide, palmitoyl pentapeptide-4, and herba Centellae extract;
preferably, the other common ingredients of the cosmetics are common cosmetic ingredients in the production of emulsion, cream, facial mask, toner or essence, and the skin care cosmetics can be emulsion, cream, facial mask, toner or essence according to different common ingredients.
The preparation method of the MXene anti-aging antioxidant skin care product is characterized by comprising the following steps:
1) respectively dissolving the water-soluble substance and the oil-soluble substance, and homogenizing and emulsifying for 5-15 minutes;
2) adding MXene antiaging and antioxidant nutrition composition, and stirring for dispersing;
3) adding auxiliary materials, and uniformly stirring and dispersing;
4) adjusting pH, stirring for 10-20 min, dispersing uniformly,
5) supplementing the evaporated water, stirring, filtering, and discharging.
The invention has the beneficial effects that: the skin care product has the capability of efficiently removing excessive oxygen free radicals in human skin, greatly reduces the damage of the free radicals to the human skin, reduces the generation of fine wrinkles, effectively delays the early aging of the skin, improves the skin moistening capability and enhances the skin elasticity; the skin care product has the effects of improving skin anti-aging, anti-oxidation, beautifying and skin care, whitening, bacteriostasis, diminishing inflammation, removing acne and the like. Meanwhile, MXene has good biocompatibility and almost no influence on the activity of cells, and can be widely used in most products needing antioxidation, such as health-care products or daily chemical products and the like.
Detailed Description
In order to facilitate the understanding of the present invention, the technical solutions of the present patent will be described in further detail with reference to the following embodiments.
The invention provides an MXene anti-aging and anti-oxidation skin care product and a preparation method thereof, and the invention is further described in detail below in order to make the purpose, technical scheme and effect of the invention clearer and more clear. It is to be understood that the specific embodiments described herein are for purposes of illustration only and are not to be construed as limiting the invention, which can be embodied in many different forms.
The MXene has excellent sterilization performance, is a physical 'antibiotic' without drug resistance, and can kill deep bacteria by destroying the structure of a mycoderm and quickly remove the mycoderm formed by MRSA. MXene and near infrared laser mainly kill bacteria through physical MXene insertion and contact and photothermal effect, thereby remarkably reducing the generation of bacterial drug resistance. The MXene has excellent antibacterial property, can completely remove bacteria from deep pores of the face, and has an anti-acne effect superior to that of similar cosmetics.
The MXene has excellent performance of eliminating free radicals, can eliminate the free radicals generated in the photoaging process, can prevent capsaicin receptor type I (TRPV 1) receptors, can reduce the expression of various inflammatory factors such as IL-1b, IL-6, IL-8, MMPs and the like, can effectively exert the photodynamic effect, can prevent the formation of photoaging, and has the effects of resisting aging and smoothing fine wrinkles superior to the similar cosmetics.
The chitosan glucosamine has a certain repairing effect on skin, and can effectively brighten skin color when being added into skin care products, so as to achieve the effects of brightening skin and repairing.
The nicotinamide of the invention can relieve and prevent the dullness of skin color generated in the early aging process of the skin, improve the resistance of the skin, repair the cuticle and strengthen the self defense capability of the skin, and has extremely strong effects of locking water and preserving moisture.
The palmitoyl pentapeptide-4 disclosed by the invention can effectively promote the hyperplasia of collagen, hyaluronic acid and elastic fibers in skin, improve the water content of the skin, increase the thickness of the skin, eliminate static lines and enhance the skin tightness and glossiness.
The centella asiatica extract component of the present invention has calming and stabilizing effects, and also removes brittle stratum corneum thinness, promotes basal metabolism of the skin, supplements the skin with the necessary nutrient elements, and assists the skin in resisting air oxidation.
Detailed description of the preferred embodiment 1
The invention provides an MXene anti-aging antioxidant skin care product and a preparation method thereof, wherein the anti-aging antioxidant nutrition composition is prepared by scientifically and organically matching and combining MXene, chitosan, nicotinamide, palmitoyl pentapeptide-4 and centella asiatica extract according to weight percentage and then placing the mixture into a known formula system of cosmetics for refining. The key components playing a role in anti-aging care on facial skin are embodied in MXene nutrition combination, MXene materials in the anti-aging and anti-oxidation effect combination, free radicals generated in a photoaging process are eliminated, capsaicin receptor I (TRPV 1) receptors are prevented, the expression of various inflammatory factors such as IL-1b, IL-6, IL-8 and MMPs is reduced, the photodynamic function is effectively played, the formation of photoaging is prevented, and the effects of anti-aging and fine grain smoothing are achieved.
The MXene anti-aging and anti-oxidation skin care product composition optionally comprises a component (B) which is a component commonly used in skin care cosmetics and comprises a medium, an active ingredient, an auxiliary material and the like. The content of component (B) in the composition of the invention is from 95 to 75% by weight, calculated on the total weight percentage of the composition, the type and amount being specifically chosen as required;
the vehicle is, for example, a diluent, a dispersant or a carrier, etc., and the type and the amount thereof are specifically selected as required;
the active ingredients comprise, for example, emollients, moisturizers, skin conditioners and the like, the type and amount of which are specifically selected as required;
the adjuvants include, for example, preservatives, fragrances, colorants, chelating agents, pH adjusters, the type and amount of which are specifically selected as desired.
The invention provides MXene anti-aging and anti-oxidation cream, which is prepared by firstly putting water-soluble substances into a water phase pot and putting oil-soluble substances into an oil phase pot according to the proportion of a formula (shown in table 1) and heating until the water-soluble substances are dissolved. Then homogenizing and emulsifying the oil phase and the water phase by using a vacuum homogenizing and emulsifying pot; adding MXene antiaging and antioxidant nutrition composition after emulsification, optionally adding essence, antiseptic, etc., adjusting pH of the product as required, stirring, cooling to room temperature, supplementing evaporated water, stirring, filtering, and packaging to obtain MXene antiaging and antioxidant cream.
Watch 1
| Composition (I) | Content (wt%) |
| Ti 3 C 2 MXene material | 0.5 |
| Water (W) | To 100 |
| EDTA disodium salt | 1 |
| Glycerol | 3 |
| Hyaluronic acid sodium salt | 0.2 |
| Acetyl chitosan glucosamine | 1 |
| Nicotinamide | 2 |
| Palmitoyl pentapeptide-4 | 1.5 |
| Centella asiatica extract | 2 |
| Butanediol | 2 |
| Carbomer | 1 |
The MXene anti-aging and anti-oxidation cream prepared in the embodiment adopts a sensory evaluation method, and the specific implementation mode is as follows: 40 office workers (female 30, age 35-50, male 10, age 30-50) were selected and divided into 4 groups for testing, and MXene antiaging and antioxidant cream prepared as described in example 1 was used for testing 40 subjects. The subjects are smeared with MXene anti-aging and anti-oxidation cream once in the morning and at night every day and are massaged by hands until the cream is completely absorbed; after the skin-care powder is continuously used for four weeks, the skin-care powder is graded according to the feeling of the testee, the grading adopts 10 grades, 1 grade is the worst, 5 grades are moderate, 10 grades are the best, and the evaluation results of the effects of moistening, allergy, elasticity, skin tenderness, wrinkle resistance and the like of 40 testees after the skin-care powder is used are shown in a table 2.
Watch two
| Group of | Moistening | Allergy (S) | Elasticity | Skin rejuvenation | Anti-wrinkle | Overall evaluation |
| A group of | 9 | 10 | 8.5 | 8.5 | 8.5 | 8.9 |
| Two groups are | 8.5 | 10 | 8 | 8.5 | 8 | 8.6 |
| Three groups | 8.5 | 10 | 8 | 8 | 9 | 8.7 |
| Four groups | 9 | 10 | 8 | 9 | 8 | 8.8 |
The MXene anti-aging and anti-oxidation cream provided by the invention is prepared by adding mild and safe anti-aging and anti-oxidation nutrition combinations into an essence formula, can effectively relieve and repair skin, reduce the generation of free radicals on the surface of the skin, resist the skin aging process and enhance the skin elasticity, has no anaphylactic reaction proved by example tests, has quite good skin care effect, and is popular among tested users and willing to continue to use the cream.
In light of the foregoing description of the preferred embodiment of the present invention, many modifications and variations will be apparent to those skilled in the art without departing from the spirit and scope of the invention. The technical scope of the present invention is not limited to the content of the specification, and must be determined according to the scope of the claims.
Claims (5)
1. An MXene anti-aging and anti-oxidation skin care product and a preparation method thereof are characterized by comprising the following components:
5-25 wt% of an anti-aging and anti-oxidant nutritional composition;
optionally, 95-75 wt% of ingredients commonly used in skin care cosmetics.
2. The MXene antiaging antioxidant skin care product of claim 1, wherein said antiaging antioxidant nutritional composition comprises: MXene, chitosan amine, nicotinamide, palmitoyl pentapeptide-4, and herba Centellae extract.
3. The MXene antiaging and antioxidant skin care preparation as claimed in claim 1, wherein said (B) optionally other ingredients commonly used in skin care cosmetics are cosmetic ingredients commonly used in production of milky lotion, cream, pack, toner or essence.
The preparation method of the MXene anti-aging and anti-oxidation skin care product is characterized by comprising the following steps:
1) respectively dissolving the water-soluble substance and the oil-soluble substance, and homogenizing and emulsifying for 5-15 minutes;
2) adding MXene antiaging and antioxidant nutrition composition, and stirring for dispersing;
3) adding auxiliary materials, and uniformly stirring and dispersing;
4) adjusting the pH value, stirring for 10-20 minutes, and uniformly dispersing;
5) supplementing the evaporated water, stirring, filtering, and discharging.
5. The MXene antiaging and antioxidant skin care product of claims 1-4, comprising eye cream, facial cream, essence, skin lotion, emulsion, and sunscreen cream.
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| CN111166683A (en) * | 2019-12-28 | 2020-05-19 | 嘉汶化妆品(东莞)有限公司 | Fullerene anti-aging antioxidant beauty and skin care cosmetic and preparation method thereof |
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| CN111166683A (en) * | 2019-12-28 | 2020-05-19 | 嘉汶化妆品(东莞)有限公司 | Fullerene anti-aging antioxidant beauty and skin care cosmetic and preparation method thereof |
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Application publication date: 20220930 |