CN115105587B - 一种防治心、脑、肺血管疾病的药物组合物 - Google Patents
一种防治心、脑、肺血管疾病的药物组合物 Download PDFInfo
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Abstract
本发明公开了一种防治心、脑、肺血管疾病的药物组合物,其由丹参、水蛭素、西洋参、当归、三七、玉竹、山药、纳豆激酶、瓜蒌、桑葚、肉苁蓉、地龙、人参、山楂、红花、甘草组成,本发明各药合理配伍,不仅具有溶解血栓,活血化瘀,通经活络,促进血液微循环,增强新陈代谢等功能,且还具有气血双补,益气补血,温脾阳,化痰饮,预防痰湿、湿热及血瘀的形成,从而可更好地对包括冠心病在内的心脑血管疾病进行有效的治疗。
Description
技术领域
本发明属于药物技术领域,具体涉及一种防治心、脑、肺血管疾病的药物组合物。
背景技术
心脑血管疾病是心脏血管和脑血管疾病的统称,泛指由于高脂血症、血液黏稠、动脉粥样硬化、高血压等所导致的心脏、大脑及全身组织发生的缺血性或出血性疾病。心脑血管疾病严重影响人类健康,血液循环和经络畅通是保证心脑健康的基本前提。人类血液循环是封闭式的,由体循环和肺循环两条途径构成的双循环。血液由左心室射出经主动脉及其各级分支流到全身的毛细血管,在此与组织液进行物质交换,供给组织细胞氧和营养物质,运走二氧化碳和代谢产物,动脉血变为静脉血;再经各级表肪汇合成上、下腔静脉流回右心房,这一循环为体循环。血液循环遇到阻碍就会出现血淤,时间久了严重影响人体健康。
中医经典著作《黄帝内经》中说:“人之所有者血与气耳”,“血气不和,百病乃变化而生”。人体内气血运行状况,决定了人体生理、病理特征,形成千变万化的症状。气血运行乃是经络系统最主要的功能,以此实现人体整体的物质能量交换。心包经不通容易导致失眠多梦易醒难入睡,心烦健忘,神经衰弱,甚至出现心脑血管疾病和心肌梗塞等病症。因此要预防和防治心脑血管疾病就要保证经络和血气畅通。冠心病医学上称冠状动脉性心脏病,系指由于冠状动脉循环发生功能的或器质性的改变而引起冠状动脉血流和心肌需求之间的不平衡导致的心肌缺血性损害的一种心脏病。冠心病的中医辨证,可归纳为如下:(1)心阳亏虚,气滞痰阻气机:表现为胸闷、头痛、心悸、气短、面色苍白或黯滞、肢冷畏寒、自汗、小便清长、大便稀薄、舌胖嫩苔白润、脉缓滑或结代。(2)心阴虚损,痰阻气机:表现为心悸、心痛、憋气、口干、耳鸣、眩晕、盗汗、夜睡不宁,夜尿多、腰酸腿软、舌嫩红苔薄白或无苔、脉细数而促或细湿而结。
现有心脑血管疾病的治疗手段主要包括:药物治疗、介入治疗和外科治疗等,其中药物治疗主要通过内服方式,如血管紧张素转换酶抑制剂(ACEI)类、血管紧张素受体拮抗剂(ARB)类、β-阻滞剂、硝酸酯类、利尿剂、α-阻滞剂、强心药及洋地黄类、调血脂药物、抗心律失常药、钙通道阻滞剂、心肌营养药等。这些药物不仅仅要求医生,患者本人以及家属也要熟悉常用的心血管疾病用药的知识,如药理作用、适应症、禁忌症、毒副作用及应用注意事项等。
发明内容
因此基于以上背景,本发明提供一种合理配伍,可多靶点防治心、脑、肺血管疾病的药物组合物。
本发明的技术方案为:
一种防治心、脑、肺血管疾病的药物组合物,其由其由丹参、西洋参、水蛭素、三七、当归、玉竹、瓜蒌、山药、白术、桑葚、肉苁蓉、地龙(地龙体内含有纤溶酶,胶原酶,蚓激酶,纤溶酶原激活物,核酸等)、人参、山楂、纳豆激酶、红花、甘草组成。
进一步地,所用原料药用量比为:丹参10~15份,西洋参5~15份,水蛭素0.3~0.5份,三七3~9份,当归6~12份,玉竹12~15份,瓜蒌10~15份,山药10~30份,白术10~15份,桑葚20~50份,肉苁蓉10~30份,地龙5~15份,人参3~10份,山楂10~30份,纳豆激酶0.3-0.8份,红花3~10份,甘草5~15份。
进一步地,其可制成口服剂。
进一步地,其剂型可为汤剂或丸剂或片剂或粉剂或丹剂或膏剂或酒剂。
本发明的原料药的药理如下:
丹参性微寒,味苦,归心、心包、肝经,具有活血化瘀,调经止血,养血安神,凉血消痈的功效。
地龙性寒,味咸,肝、脾、膀胱经,可通经络,活血化瘀,又能平肝泻火,故对瘀血阻于络脉者多奇效,经现代科学研究证明,地龙体内含有纤溶酶,胶原酶,蚓激酶,纤溶酶原激活物,核酸等。
纳豆激酶具有:促进人体排毒代谢溶解血栓降低血脂血糖的功效。
水蛭素对凝血酶有很强的抑制作用,能够溶解陈旧血栓,有极强的抑制凝血作用和抗血栓形成作用。
三七性温,味甘,微苦,归肝经,胃经,具有化瘀止血,活血定痛,解毒消肿的功效。
当归性温,辛,味甘,归肝,心,脾经,具有补血活血,润肠通便之功效。
玉竹性微寒,味甘,归肺,胃经,具有养阴润燥,生津止咳等功效。
瓜篓性寒,归肺,胃,大肠经,能清热涤痰,宽胸散结,润肠通便之功效。
白术性温,味甘,微辛带苦,入脾经,胃经,具有利尿消肿,固表止汗,润湿健脾,抗氧化等作用。
山药性凉润,味甘,入肺,脾,肾经,有健脾养胃,益肺止咳,滋肾益精等功效。
肉苁蓉性温,味甘咸,归肾经,大肠经具有补肾阳,益精血,润肠通便之功效。
桑葚性寒,味甘,入肾经,肝经,具有补肾益肝的作用。
人参性温,味甘,微苦,入脾,肺,心,肾经,具有大补元气,复脉固脱,补脾益肺,生津养血,安神益智之功效。
山楂性微温,味酸,甘,有健脾消食,扩张血管,改善心脏活力之功效。
西洋参有养阴生精津,养心益肺,提神滋肾之功。
红花性温,味辛,归心经,肝经,具有活血,通经,散瘀止痛之功效。甘草能补脾益气,清热解毒,祛痰止咳,缓急止痛,并有调和诸药之功效。
中医经典著作《黄帝内经》中《素问.调经论》说:“人之所有者血与气耳”,“血气不和,百病乃变化而生”。人体内气血运行状况,决定了人体生理、病理特征,形成千变万化的症状。气血运行乃是经络系统最主要的功能,以此实现人体整体的物质能量交换。心包经不通容易导致失眠多梦易醒难入睡,心烦健忘,神经衰弱,甚至出现心脑血管疾病和心肌梗塞等病症。预防和防治心脑血管疾病需保证经络和血气畅通,本发明以水蛭素为君药,以溶血栓之功;纳豆激酶、丹参为臣药,与水蛭素配伍以加强陈旧血栓溶解,以三七、丹参、地龙、红花、玉竹、瓜蒌、白术、山药、肉苁蓉、桑葚、山楂、当归、人参、西洋参为臣药,其中三七、丹参、地龙、红花活血化瘀,通经活络,散瘀止痛与水蛭素、纳豆激酶配伍促进血液微循环,增强新陈代谢,利于将血液中所溶血栓、瘀血滞气等排出,降低血压、血脂,且辅以当归、人参、西洋参以气血双补,益气补血,以调整气血,更进气血调畅,血脉通达;玉竹、瓜蒌、白术、山药、肉苁蓉、桑葚、山楂配伍,以温脾阳,化痰饮,以通心脉;补脾胃,益气血,以养心脉,以预防痰湿、湿热及血瘀的形成;甘草为使药,调和诸药,因此本发明以中医的“君臣佐使”理论为依据,合理配伍,共达对心、脑、肺血管疾病进行防治的目的。
具体实施方式
应该指出,以下详细说明都是示例性的,旨在对本发明提供进一步的说明。除非另有指明,本文使用的所有技术和科学术语具有与本发明所属技术领域的普通技术人员通常理解的相同含义。
需要注意的是,这里所使用的术语仅是为了描述具体实施方式,而非意图限制根据本发明的示例性实施方式。如在这里所使用的,除非上下文另外明确指出,否则单数形式也意图包括复数形式,此外,还应当理解的是,当在本说明书中使用术语“包含”和/或“包括”时,其指明存在特征、步骤、操作和/或它们的组合。
实施例1:一种防治心、脑、肺血管疾病的药物组合物,所用原料药用量比为:丹参10~15份,西洋参5~15份,水蛭素0.3-0.5份,三七3~9份,当归6~12份,玉竹12~15份,瓜蒌10~15份,山药10~30份,白术10~15份,桑葚20~50份,肉苁蓉10~30份,地龙5~15份,人参3~10份,山楂10~30份,纳豆激酶0.3-0.8份,红花3~10份,甘草5~15份。
本实施例可加入常用的辅剂制成丸剂,每丸1g。
建议服用剂量为:一日三次,一次5-8丸。
归属心脑血管疾病的冠心病的发病虽涉及多个脏腑,但鉴于心胃之间关系密切,故又尤以中焦脾胃为著。冠心病属于中医的“胸痹”“心痛”范畴。脾胃为仓廪之官,胃主受纳腐熟水谷,脾主运化输布水谷精微,升清降浊,为气血生化之源,但脾胃功能有赖于心的主宰,脾胃虚弱又可影响心的功能。若脾气虚弱,运化无权,可使心气推动无力,心血化源不足,化源不足则致血虚,血虚则心失所养;脾不统血,失血过多,亦会导致心血不足,出现胸闷心悸、失眠多梦、纳呆食少、腹胀便溏等心脾两虚症状。心主血脉,脾主统血,心脾两脏的功能正常,保证了血液生成。且脾为生痰之源,脾虚水谷精微不能得以输布,则易留滞成湿,气滞郁而化热,湿热则易成。脾运化失调导致气虚,无力推动血行而致血瘀。故痰湿、湿热、血瘀之邪均归因于脾胃功能受损,因此本发明药物还从脾胃着手,采用玉竹、瓜蒌、白术、山药、肉苁蓉、桑葚、山楂配伍,以温脾阳,化痰饮,以通心脉;补脾胃,益气血,以养心脉,以预防痰湿、湿热及血瘀的形成。
人体五脏六腑息息相关,相护相承,本发明组方诸药合理配伍,可对患者心慌,心悸,心痛等临床症状进行有效的治疗,以及组药还对人体五脏六腑以调和调养,提高人体免疫力,从源头上解决了致病的根源,进而达到了标本兼治的显著疗效。
实施例2:典型案例
案例1:患者李先生,男,57岁,患有严重冠心病,做过支架手术,但从2022年开春以来还是经常出现胸闷,胸痛,半夜睡觉暂停呼吸等症状。
治疗:在连续服用本发明药剂7天后,心慌,心悸,胸闷气短等症状有明显缓解,继续服用一个月后,所有症状都消失。
上述实施例为本发明较佳的实施方式,但本发明的实施方式并不受上述实施例的限制,其他的任何未背离本发明的精神实质与原理下所作的改变、修饰、替代、组合、简化,均应为等效的置换方式,都包含在本发明的保护范围之内。
Claims (3)
1.一种防治心脑血管疾病的中药组合物,其特征在于,其由丹参、西洋参、水蛭素、三七、当归、玉竹、瓜蒌、山药、白术、桑葚、肉苁蓉、地龙、人参、山楂、纳豆激酶、红花、甘草组成;
所用原料药用量比为:丹参10~15份,西洋参5~15份,水蛭素0.3-0.5份,三七3~9份,当归6~12份,玉竹12~15份,瓜蒌10~15份,山药10~30份,白术10~15份,桑葚20~50份,肉苁蓉10~30份,地龙5~15份,人参3~10份,山楂10~30份,纳豆激酶0.3-0.8份,红花3~10份,甘草5~15份。
2.根据权利要求1所述的一种防治心脑血管疾病的中药组合物,其特征在于,其制成口服剂。
3.根据权利要求1所述的一种防治心脑血管疾病的中药组合物,其特征在于,其剂型做成汤剂或丸剂或片剂或粉剂或膏剂。
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