CN115103667A - 用于治疗性用途的充气微囊泡 - Google Patents

用于治疗性用途的充气微囊泡 Download PDF

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Publication number
CN115103667A
CN115103667A CN202180013722.9A CN202180013722A CN115103667A CN 115103667 A CN115103667 A CN 115103667A CN 202180013722 A CN202180013722 A CN 202180013722A CN 115103667 A CN115103667 A CN 115103667A
Authority
CN
China
Prior art keywords
suspension
gas
microvesicles
filled
administered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180013722.9A
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English (en)
Chinese (zh)
Inventor
V·珍诺特
A·赫尔伯特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Suisse SA
Original Assignee
Bracco Suisse SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Suisse SA filed Critical Bracco Suisse SA
Publication of CN115103667A publication Critical patent/CN115103667A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/16—Fluorine compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202180013722.9A 2020-02-11 2021-02-10 用于治疗性用途的充气微囊泡 Pending CN115103667A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062975005P 2020-02-11 2020-02-11
US62/975,005 2020-02-11
PCT/EP2021/053183 WO2021160659A1 (en) 2020-02-11 2021-02-10 Gas-filled microvesicles for therapeutic use

Publications (1)

Publication Number Publication Date
CN115103667A true CN115103667A (zh) 2022-09-23

Family

ID=74625954

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180013722.9A Pending CN115103667A (zh) 2020-02-11 2021-02-10 用于治疗性用途的充气微囊泡

Country Status (7)

Country Link
US (1) US20230057224A1 (https=)
EP (1) EP4103152B1 (https=)
JP (1) JP7743415B2 (https=)
KR (1) KR20220140527A (https=)
CN (1) CN115103667A (https=)
CA (1) CA3165200A1 (https=)
WO (1) WO2021160659A1 (https=)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5445813A (en) 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
JP4670083B2 (ja) 2003-02-04 2011-04-13 ブラッコ・シュイス・ソシエテ・アノニム 超音波造影剤およびその製造方法
CA2748995C (en) * 2008-10-07 2018-01-16 Bracco Suisse Sa Targeting construct comprising anti-polymer antibody and liposomes or microvesicles binding to the same
EP2934740B1 (en) * 2012-12-21 2019-12-11 Bracco Suisse SA Gas-filled microvesicles
EP3233136B8 (en) * 2014-12-18 2019-04-10 Bracco Suisse SA Targeted gas-filled microvesicles formulation
CN107206065A (zh) * 2014-12-22 2017-09-26 博莱科瑞士股份有限公司 用作疫苗的气体填充的微囊

Also Published As

Publication number Publication date
EP4103152B1 (en) 2025-07-23
KR20220140527A (ko) 2022-10-18
WO2021160659A1 (en) 2021-08-19
US20230057224A1 (en) 2023-02-23
JP2023512943A (ja) 2023-03-30
EP4103152A1 (en) 2022-12-21
JP7743415B2 (ja) 2025-09-24
CA3165200A1 (en) 2021-08-19
EP4103152C0 (en) 2025-07-23

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