CN115089534A - Soothing and moisturizing essence and preparation method thereof - Google Patents
Soothing and moisturizing essence and preparation method thereof Download PDFInfo
- Publication number
- CN115089534A CN115089534A CN202210760450.5A CN202210760450A CN115089534A CN 115089534 A CN115089534 A CN 115089534A CN 202210760450 A CN202210760450 A CN 202210760450A CN 115089534 A CN115089534 A CN 115089534A
- Authority
- CN
- China
- Prior art keywords
- parts
- skin
- skin care
- extract
- moisturizing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 33
- 238000002360 preparation method Methods 0.000 title claims description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 72
- 239000000284 extract Substances 0.000 claims abstract description 65
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims abstract description 38
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims abstract description 26
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229960003471 retinol Drugs 0.000 claims abstract description 19
- 235000020944 retinol Nutrition 0.000 claims abstract description 19
- 239000011607 retinol Substances 0.000 claims abstract description 19
- 235000013500 Melia azadirachta Nutrition 0.000 claims abstract description 17
- 229930182478 glucoside Natural products 0.000 claims abstract description 16
- -1 glycerol glucoside Chemical class 0.000 claims abstract description 16
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims abstract description 13
- 229920002498 Beta-glucan Polymers 0.000 claims abstract description 13
- 239000003755 preservative agent Substances 0.000 claims abstract description 11
- 239000000203 mixture Substances 0.000 claims abstract description 10
- 230000002335 preservative effect Effects 0.000 claims abstract description 10
- 239000000419 plant extract Substances 0.000 claims abstract description 8
- 239000003906 humectant Substances 0.000 claims abstract description 5
- 239000002904 solvent Substances 0.000 claims abstract description 5
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 46
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 46
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 46
- 235000011187 glycerol Nutrition 0.000 claims description 28
- 239000011259 mixed solution Substances 0.000 claims description 28
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 26
- 229920002674 hyaluronan Polymers 0.000 claims description 26
- 229960003160 hyaluronic acid Drugs 0.000 claims description 26
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 22
- 238000002156 mixing Methods 0.000 claims description 21
- 244000237986 Melia azadirachta Species 0.000 claims description 15
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 14
- 235000003130 Arctium lappa Nutrition 0.000 claims description 14
- 235000008078 Arctium minus Nutrition 0.000 claims description 14
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 14
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims description 14
- 238000003756 stirring Methods 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- BNMGUJRJUUDLHW-HCZMHFOYSA-N Madecassoside Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(C[C@@H](O)[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O BNMGUJRJUUDLHW-HCZMHFOYSA-N 0.000 claims description 13
- BNMGUJRJUUDLHW-HLUHVYOBSA-N Madecassoside Natural products C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5[C@H](O)C[C@@]34C)[C@@H]2[C@H]1C)C(=O)O[C@@H]6O[C@H](CO[C@@H]7O[C@H](CO)[C@@H](O[C@@H]8O[C@H](C)[C@H](O)[C@@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@@H](O)[C@H](O)[C@H]6O BNMGUJRJUUDLHW-HLUHVYOBSA-N 0.000 claims description 13
- QCYLIQBVLZBPNK-UHFFFAOYSA-N asiaticoside A Natural products O1C(C(=O)C(C)C)=CC(C)C(C2(C(OC(C)=O)CC34C5)C)C1CC2(C)C3CCC(C1(C)C)C45CCC1OC1OCC(O)C(O)C1O QCYLIQBVLZBPNK-UHFFFAOYSA-N 0.000 claims description 13
- 229940090813 madecassoside Drugs 0.000 claims description 13
- VFKZECOCJCGZQK-UHFFFAOYSA-M 3-hydroxypropyl(trimethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CCCO VFKZECOCJCGZQK-UHFFFAOYSA-M 0.000 claims description 12
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 12
- 229920006037 cross link polymer Polymers 0.000 claims description 12
- 229940101267 panthenol Drugs 0.000 claims description 12
- 239000011619 pantothenol Substances 0.000 claims description 12
- 235000020957 pantothenol Nutrition 0.000 claims description 12
- 244000025254 Cannabis sativa Species 0.000 claims description 9
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 7
- 229940100524 ethylhexylglycerin Drugs 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 7
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 claims description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 2
- 229940035437 1,3-propanediol Drugs 0.000 claims description 2
- 229960005150 glycerol Drugs 0.000 claims description 2
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims description 2
- 239000004909 Moisturizer Substances 0.000 claims 2
- 230000001333 moisturizer Effects 0.000 claims 2
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 claims 1
- 240000004246 Agave americana Species 0.000 claims 1
- 240000005528 Arctium lappa Species 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 229940014041 hyaluronate Drugs 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 210000003491 skin Anatomy 0.000 abstract description 51
- 244000193174 agave Species 0.000 abstract description 19
- 230000000694 effects Effects 0.000 abstract description 17
- 230000002087 whitening effect Effects 0.000 abstract description 15
- 230000037303 wrinkles Effects 0.000 abstract description 9
- 210000004927 skin cell Anatomy 0.000 abstract description 7
- 150000003254 radicals Chemical class 0.000 abstract description 5
- 208000002874 Acne Vulgaris Diseases 0.000 abstract description 3
- 206010000496 acne Diseases 0.000 abstract description 3
- 230000003078 antioxidant effect Effects 0.000 abstract description 3
- 230000036619 pore blockages Effects 0.000 abstract description 3
- 229940045997 vitamin a Drugs 0.000 abstract description 3
- 240000005343 Azadirachta indica Species 0.000 abstract 2
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 235000006708 antioxidants Nutrition 0.000 abstract 1
- 230000037319 collagen production Effects 0.000 abstract 1
- 239000000686 essence Substances 0.000 description 38
- 241000208843 Arctium Species 0.000 description 13
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 10
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 description 6
- 230000002401 inhibitory effect Effects 0.000 description 6
- 230000009286 beneficial effect Effects 0.000 description 5
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 4
- 230000003110 anti-inflammatory effect Effects 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 239000006071 cream Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 102000029816 Collagenase Human genes 0.000 description 2
- 108060005980 Collagenase Proteins 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 108010003272 Hyaluronate lyase Proteins 0.000 description 2
- 102000001974 Hyaluronidases Human genes 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 2
- 102000016387 Pancreatic elastase Human genes 0.000 description 2
- 108010067372 Pancreatic elastase Proteins 0.000 description 2
- 229930182558 Sterol Natural products 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000001153 anti-wrinkle effect Effects 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 229940106189 ceramide Drugs 0.000 description 2
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 229960002424 collagenase Drugs 0.000 description 2
- 238000005536 corrosion prevention Methods 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 229960002773 hyaluronidase Drugs 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 230000009759 skin aging Effects 0.000 description 2
- 150000003432 sterols Chemical class 0.000 description 2
- 235000003702 sterols Nutrition 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000036564 melanin content Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000004126 nerve fiber Anatomy 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to a skin care essence which comprises the following components in percentage by mass: agave leaf extract, neem leaf extract, glycerol glucoside, plant extract, p-hydroxyacetophenone, beta-glucan, humectant, moisturizing preservative and solvent. The neem leaf extract and the agave leaf extract are added into the composition, so that the moisture-keeping and health-care effect is achieved on the skin, and in addition, the added glycerol glucoside also has the moisture-keeping and antioxidant functions. And retinol, which is essentially a derivative of vitamin a, helps to cope with free radical damage, can promote skin cell renewal, brighten skin color, reduce acne, promote collagen production, and also can remove dead skin cells, prevent pore blockage and skin darkness. In conclusion, the skin care essence disclosed by the application is improved in the aspects of moisturizing, wrinkle resisting and whitening, provides the essence with the effects of basic moisturizing, whitening and wrinkle resisting, and can better activate the skin.
Description
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to a soothing and moisturizing essence and a preparation method thereof.
Background
Currently, the skin of people is sensitive and rough due to the living environment and the working pressure. Poor and rich sensitivity is caused by the fact that skin cells are damaged to reduce the immunity of the skin, the skin is not moistened enough due to the fact that the horny layer is thinned, and finally the barrier function of the skin is too weak to resist external stimulation. Then, the nerve fibers of the skin are often stimulated and excited too much, so that the phenomena of redness, fever, itching, stabbing pain, red rash and the like are easily caused.
The essence is one of skin care products for face, and contains precious functional components. The essence is usually applied after the skin lotion, before the lotion or cream. The essence is rich in various functional components and has higher concentration, so the price is generally more expensive than other cosmetics. The existing essence mostly focuses on the effects of quickly whitening, resisting wrinkles, removing spots and the like for users, but ignores the most important effects of relieving skin sensitivity and moisturizing, but is difficult to improve the skin in a short time to realize more effects.
Disclosure of Invention
In order to improve the effects of the essence on moisturizing and soothing the skin and lay a good foundation for subsequent skin care, the invention provides the soothing and moisturizing essence and the preparation method thereof.
In a first aspect, the invention provides a skin care essence, which comprises the following components in percentage by mass:
further, the liquid crystal composition also comprises retinol, wherein the retinol accounts for 4-8 parts by weight.
Further, the plant extract also comprises 3-8 parts by weight of madecassoside.
Further, the plant extract comprises one or a mixture of more than two of burdock extract and grass-containing extract.
Further, the humectant comprises 5-15 parts by weight of sodium hyaluronate.
Further, the humectant also comprises one or a mixture of more than two of hydroxypropyl trimethyl ammonium chloride hyaluronic acid, sodium hyaluronate cross-linked polymer, hydrolyzed sodium hyaluronate and hyaluronic acid.
Further, the moisture preserving preservative comprises one or a mixture of more than two of 1, 2-hexanediol and 1, 2-pentanediol.
Further, the moisture-preserving preservative also comprises ethylhexyl glycerin, and the mass portion of the ethylhexyl glycerin is 1-2.
Further, the solvent includes water, butylene glycol, glycerin, 1, 3-propanediol, and panthenol.
In a second aspect, the application provides a method for preparing a soothing and moisturizing essence, comprising the following steps:
(1) mixing the agave leaf extract, the neem leaf extract, the plant extract, the p-hydroxyacetophenone and the moisturizing preservative, heating to 80-85 ℃, preserving heat for 15-20 min, and uniformly stirring to obtain a mixed solution A;
(2) uniformly mixing glycerol glucoside, beta-glucan, a humectant and a solvent to obtain a mixed solution B;
(3) and mixing the mixed solution A and the mixed solution B at 80-85 ℃, uniformly stirring and homogenizing for 5min at the speed of 60r/min, preserving heat for 30-40 min, cooling to below 35 ℃, and filtering to obtain the soothing and moisturizing essence.
In conclusion, the invention has the following beneficial effects:
1. the neem leaf extract is added, and the plant extract can eliminate free radicals and has an antioxidant effect; has strong inhibiting effect on various fungi and bacteria, can absorb moisture under low humidity, and has moisture keeping effect; meanwhile, the whitening cream also has a certain whitening effect. Meanwhile, the added agave leaf extract has an inhibition effect on hyaluronidase, which shows that the added agave leaf extract can effectively inhibit the decomposition of hyaluronic acid in use, thereby having a skin moisturizing effect, and in addition, the added agave leaf extract can be used as an allergy inhibitor for inhibiting free histamine; inhibition of elastase and collagenase activity indicates anti-wrinkle effect. Finally, active ingredients capable of stimulating the skin to secrete ceramide, sterol and the like are added, so that an endogenous moisturizing green grass-containing extract and a burdock extract capable of inhibiting the growth of microorganisms and keeping the microecological balance on the surface of the skin are realized.
2. The application also adds glycerol glucoside, which is a substance formed by combining glycerol and glucose molecules by glycosidic bonds and has the functions of moisture retention and oxidation resistance.
3. The added 1, 2-hexanediol and 1, 2-pentanediol have the moisturizing effect and a good antibacterial function, and therefore the moisture-preserving preservative can be used as a moisture-preserving preservative for water locking and corrosion prevention.
4. Retinol, which is essentially a derivative of vitamin a, is also added. The skin care product is beneficial to dealing with free radical damage, can promote the renewal of skin cells, brighten the skin color, reduce acne, promote the generation of collagen, and can also clear dead skin cells and prevent pore blockage and skin darkness; also can reduce wrinkles, even skin color and repair color spots, can effectively resist skin aging and is beneficial to delaying aging.
In conclusion, the skin care essence provided by the application is improved in moisturizing, wrinkle resisting and whitening aspects, provides the essence with basic moisturizing, whitening and wrinkle resisting effects, and can well activate the skin.
Detailed Description
The present invention will be described in further detail with reference to examples.
Example 1
The skin care essence comprises the following components in percentage by mass:
3 parts of agave leaf extract;
3 parts of neem leaf extract;
6 parts of glycerol glucoside;
4 parts of retinol;
3 parts of madecassoside;
4 parts of burdock extract;
contains 3 parts of raw grass extract;
1 part of p-hydroxyacetophenone;
3 parts of beta-glucan;
5 parts of sodium hyaluronate;
4 parts of acetylated sodium hyaluronate;
1 part of hydroxypropyl trimethyl ammonium chloride hyaluronic acid;
1 part of sodium hyaluronate cross-linked polymer;
1 part of hydrolyzed sodium hyaluronate;
1 part of hyaluronic acid;
1 part of 1, 2-hexanediol;
1 part of 1, 2-pentanediol;
1 part of ethylhexyl glycerol;
25 parts of water;
5 parts of glycerol;
5 parts of butanediol;
5 parts of 1, 3-propylene glycol;
5 parts of panthenol.
The preparation method of the skin care essence in the embodiment comprises the following steps:
(1) mixing folium agaves Variegatae extract, folium Azadirachta indica extract, madecassoside, Burdock extract, extract containing herba Hyperici Japonici, p-hydroxyacetophenone, 1, 2-hexanediol, 1, 2-pentanediol, and ethylhexyl glycerin, heating to 80 deg.C, keeping the temperature for 15min, and stirring to obtain mixed solution A;
(2) uniformly mixing glycerol glucoside, beta-glucan, retinol, sodium hyaluronate, acetylated sodium hyaluronate, hydroxypropyl trimethyl ammonium chloride hyaluronic acid, sodium hyaluronate cross-linked polymer, hydrolyzed sodium hyaluronate, hyaluronic acid, water, butanediol, glycerol, 1, 3-propylene glycol and panthenol to obtain a mixed solution B;
(3) and mixing the mixed solution A and the mixed solution B at 80 ℃, uniformly stirring and homogenizing for 5min at the speed of 60r/min, preserving heat for 30min, cooling to below 35 ℃, and filtering to obtain the soothing and moisturizing essence.
Example 2
The skin care essence comprises the following components in percentage by mass:
8 parts of agave leaf extract;
8 parts of neem leaf extract;
12 parts of glycerol glucoside;
8 parts of retinol;
8 parts of madecassoside;
6 parts of burdock extract;
6 parts of raw grass extract;
2 parts of p-hydroxyacetophenone;
5 parts of beta-glucan;
15 parts of sodium hyaluronate;
10 parts of acetylated sodium hyaluronate;
3 parts of hydroxypropyl trimethyl ammonium chloride hyaluronic acid;
3 parts of sodium hyaluronate cross-linked polymer;
2 parts of hydrolyzed sodium hyaluronate;
2 parts of hyaluronic acid;
3 parts of 1, 2-hexanediol;
3 parts of 1, 2-pentanediol;
2 parts of ethylhexyl glycerol;
30 parts of water;
10 parts of glycerol;
10 parts of butanediol;
10 parts of 1, 3-propylene glycol;
10 parts of panthenol.
The preparation method of the skin care essence in the embodiment comprises the following steps:
(1) mixing the agave leaf extract, the neem leaf extract, the madecassoside, the burdock extract, the raw grass-containing extract, the p-hydroxyacetophenone, the 1, 2-hexanediol, the 1, 2-pentanediol and the ethylhexyl glycerin, heating to 80-85 ℃, preserving heat for 20min, and uniformly stirring to obtain a mixed solution A;
(2) uniformly mixing glycerol glucoside, beta-glucan, retinol, sodium hyaluronate, acetylated sodium hyaluronate, hydroxypropyl trimethyl ammonium chloride hyaluronic acid, sodium hyaluronate cross-linked polymer, hydrolyzed sodium hyaluronate, hyaluronic acid, water, butanediol, glycerol, 1, 3-propylene glycol and panthenol to obtain a mixed solution B;
(3) and mixing the mixed solution A and the mixed solution B at 85 ℃, uniformly stirring and homogenizing for 5min at the speed of 60r/min, preserving heat for 40min, cooling to below 35 ℃, and filtering to obtain the soothing and moisturizing essence.
Example 3
The skin care essence comprises the following components in percentage by mass:
5 parts of agave leaf extract;
5 parts of neem leaf extract;
8 parts of glycerol glucoside;
6 parts of retinol;
5 parts of madecassoside;
5 parts of burdock extract;
5 parts of raw grass extract;
1 part of p-hydroxyacetophenone;
4 parts of beta-glucan;
10 parts of sodium hyaluronate;
6 parts of acetylated sodium hyaluronate;
2 parts of hydroxypropyl trimethyl ammonium chloride hyaluronic acid;
2 parts of sodium hyaluronate cross-linked polymer;
2 parts of hydrolyzed sodium hyaluronate;
2 parts of hyaluronic acid;
2 parts of 1, 2-hexanediol;
2 parts of 1, 2-pentanediol;
2 parts of ethylhexyl glycerol;
27 parts of water;
7 parts of glycerol;
7 parts of butanediol;
7 parts of 1, 3-propylene glycol;
7 parts of panthenol.
The preparation method of the skin care essence in the embodiment comprises the following steps:
(1) mixing folium agaves Variegatae extract, folium Azadirachta indica extract, madecassoside, Burdock extract, extract containing herba Hyperici Japonici, p-hydroxyacetophenone, 1, 2-hexanediol, 1, 2-pentanediol, and ethylhexyl glycerin, heating to 83 deg.C, keeping the temperature for 17min, and stirring to obtain mixed solution A;
(2) uniformly mixing glycerol glucoside, beta-glucan, retinol, sodium hyaluronate, acetylated sodium hyaluronate, hydroxypropyl trimethyl ammonium chloride hyaluronic acid, sodium hyaluronate cross-linked polymer, hydrolyzed sodium hyaluronate, hyaluronic acid, water, butanediol, glycerol, 1, 3-propylene glycol and panthenol to obtain a mixed solution B;
(3) and mixing the mixed solution A and the mixed solution B at 83 ℃, uniformly stirring and homogenizing for 5min at the speed of 60r/min, preserving heat for 35min, cooling to below 35 ℃, and filtering to obtain the soothing and moisturizing essence.
Example 4
The skin care essence comprises the following components in percentage by mass:
6 parts of agave leaf extract;
6 parts of neem leaf extract;
9 parts of glycerol glucoside;
7 parts of retinol;
6 parts of madecassoside;
5 parts of burdock extract;
5 parts of raw grass extract;
1 part of p-hydroxyacetophenone;
4 parts of beta-glucan;
12 parts of sodium hyaluronate;
8 parts of acetylated sodium hyaluronate;
2 parts of hydroxypropyl trimethyl ammonium chloride hyaluronic acid;
2 parts of sodium hyaluronate cross-linked polymer;
2 parts of hydrolyzed sodium hyaluronate;
2 parts of hyaluronic acid;
2 parts of 1, 2-hexanediol;
2 parts of 1, 2-pentanediol;
2 parts of ethylhexyl glycerol;
27 parts of water;
8 parts of glycerol;
8 parts of butanediol;
8 parts of 1, 3-propylene glycol;
8 parts of panthenol.
The preparation method of the skin care essence in the embodiment comprises the following steps:
(1) mixing folium agaves Variegatae extract, folium Azadirachta indica extract, madecassoside, Burdock extract, extract containing herba Hyperici Japonici, p-hydroxyacetophenone, 1, 2-hexanediol, 1, 2-pentanediol, and ethylhexyl glycerin, heating to 83 deg.C, keeping the temperature for 17min, and stirring to obtain mixed solution A;
(2) uniformly mixing glycerol glucoside, beta-glucan, retinol, sodium hyaluronate, acetylated sodium hyaluronate, hydroxypropyl trimethyl ammonium chloride hyaluronic acid, sodium hyaluronate cross-linked polymer, hydrolyzed sodium hyaluronate, hyaluronic acid, water, butanediol, glycerol, 1, 3-propylene glycol and panthenol to obtain a mixed solution B;
(3) and mixing the mixed solution A and the mixed solution B at 83 ℃, uniformly stirring and homogenizing for 5min at the speed of 60r/min, keeping the temperature for 35min, cooling to below 35 ℃, and filtering to obtain the soothing and moisturizing essence.
Example 5
The skin care essence comprises the following components in percentage by mass:
7 parts of agave leaf extract;
7 parts of neem leaf extract;
10 parts of glycerol glucoside;
7 parts of retinol;
7 parts of madecassoside;
5 parts of burdock extract;
5 parts of raw grass extract;
1 part of p-hydroxyacetophenone;
4 parts of beta-glucan;
13 parts of sodium hyaluronate;
8 parts of acetylated sodium hyaluronate;
2 parts of hydroxypropyl trimethyl ammonium chloride hyaluronic acid;
2 parts of sodium hyaluronate cross-linked polymer;
2 parts of hydrolyzed sodium hyaluronate;
2 parts of hyaluronic acid;
2 parts of 1, 2-hexanediol;
2 parts of 1, 2-pentanediol;
2 parts of ethylhexyl glycerol;
27 parts of water;
8 parts of glycerol;
8 parts of butanediol;
8 parts of 1, 3-propylene glycol;
8 parts of panthenol.
The preparation method of the skin care essence in the embodiment comprises the following steps:
(1) mixing folium agaves Variegatae extract, folium Azadirachta indica extract, madecassoside, Burdock extract, extract containing herba Hyperici Japonici, p-hydroxyacetophenone, 1, 2-hexanediol, 1, 2-pentanediol, and ethylhexyl glycerol, heating to 83 deg.C, maintaining the temperature for 17min, and stirring to obtain mixed solution A;
(2) uniformly mixing glycerol glucoside, beta-glucan, retinol, sodium hyaluronate, acetylated sodium hyaluronate, hydroxypropyl trimethyl ammonium chloride hyaluronic acid, sodium hyaluronate cross-linked polymer, hydrolyzed sodium hyaluronate, hyaluronic acid, water, butanediol, glycerol, 1, 3-propylene glycol and panthenol to obtain a mixed solution B;
(3) and mixing the mixed solution A and the mixed solution B at 83 ℃, uniformly stirring and homogenizing for 5min at the speed of 60r/min, keeping the temperature for 35min, cooling to below 35 ℃, and filtering to obtain the soothing and moisturizing essence.
Comparative example 1
A certain commercially available skin care essence.
Performance test
1. Evaluation of moisturizing efficacy
Experiments are carried out according to the standard of QB-T4526-. The essences of examples 1 to 5 were used for the second group to the sixth group, respectively. The results of the measurements were obtained every three hours and four times for each person and are shown in Table 1.
2. Evaluation of anti-inflammatory Effect
60 volunteers of 20-60 years old are recruited, all the volunteers are randomly divided into six groups of 10 persons in each group, the first group uses the existing product, and the existing product is skin care essence purchased in the market. The essences of examples 1 to 5 were used for the second group to the sixth group, respectively. The anti-inflammatory effect is shown in Table 1 when the composition is taken once a day for 30 days.
3. Evaluation of elastic Effect
60 20-60-year-old volunteers are recruited, all the volunteers are randomly divided into six groups of 10 persons each, the first group uses the existing product, and the existing product is skin care essence purchased on the market. The essences of examples 1 to 5 were used for the second group to the sixth group, respectively. The skin elasticity tester is used by each person once a day for 30 days continuously, and the elasticity effect results are shown in table 1.
4. Evaluation of whitening Effect
60 volunteers of 20-60 years old are recruited, all the volunteers are randomly divided into six groups of 10 persons in each group, the first group uses the existing product, and the existing product is skin care essence purchased in the market. The essences of examples 1 to 5 were used for the second group to the sixth group, respectively. The skin melanin content before and on day 30 was measured by a melanin measuring instrument once a day for 30 consecutive days, and the result is expressed as a melanin reduction amount Δ MI, and the result is shown in table 1.
TABLE 1
As can be seen from table 1, the moisturizing effect and the anti-inflammatory effect of the first group were general, and the improvement of the elasticity and the whitening was also poor. The second group to the sixth group are improved significantly. The sixth group was particularly evident, indicating that the anti-inflammatory and whitening effects of several extracts such as neem leaf extract are more significant; and secondly, the whitening effect of the added retinol is remarkably improved on the basis of better moisturizing performance. The above results effectively show that the products using the present invention have outstanding effects and advantages with the existing products on the market.
In summary, the present application adds neem leaf extract, which is capable of scavenging free radicals and has antioxidant effect; has strong inhibiting effect on various fungi and bacteria, can absorb moisture under low humidity, and has moisture keeping effect; meanwhile, the whitening cream also has a certain whitening effect. Meanwhile, the added agave leaf extract has an inhibition effect on hyaluronidase, which shows that the added agave leaf extract can effectively inhibit the decomposition of hyaluronic acid in use, thereby having a skin moisturizing effect, and in addition, the added agave leaf extract can be used as an allergy inhibitor for inhibiting free histamine; inhibition of elastase and collagenase activity indicates anti-wrinkle effect. Finally, active ingredients capable of stimulating the skin to secrete ceramide, sterol and the like are added, so that endogenous moisturizing is achieved, and the burdock extract capable of inhibiting microbial growth and keeping the microecological balance on the surface of the skin is also added. The application also adds glycerol glucoside, which is a substance formed by combining glycerol and glucose molecules by glycosidic bonds and has the functions of moisture retention and oxidation resistance. The added 1, 2-hexanediol and 1, 2-pentanediol have the moisturizing effect and a good antibacterial function, and therefore the moisture-preserving preservative can be used as a moisture-preserving preservative for water locking and corrosion prevention. Retinol, which is essentially a derivative of vitamin a, is also added. The skin care product is beneficial to dealing with free radical damage, can promote the renewal of skin cells, brighten the skin color, reduce acne, promote the generation of collagen, and can also clear dead skin cells and prevent pore blockage and skin darkness; also can reduce wrinkles, even skin color and repair color spots, can effectively resist skin aging and is beneficial to delaying aging. In conclusion, the skin care essence disclosed by the application is improved in the aspects of moisturizing, wrinkle resisting and whitening, provides the essence with the effects of basic moisturizing, whitening and wrinkle resisting, and can better activate the skin.
The present embodiment is only for explaining the present invention, and it is not limited to the present invention, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present invention.
Claims (10)
1. The skin care essence is characterized by comprising the following components in percentage by mass:
2. the skin care essence according to claim 1, further comprising retinol, wherein the retinol is 4-8 parts by weight.
3. The skin care essence according to claim 1, wherein the plant extract further comprises madecassoside, and the madecassoside accounts for 3-8 parts by mass.
4. The skin care essence according to claim 1, wherein the plant extract comprises one or a mixture of more than two of burdock extract and grass-containing extract.
5. The skin care essence according to claim 1, wherein the moisturizer comprises one or a mixture of two or more of sodium hyaluronate and sodium acetylated hyaluronate.
6. The skin care essence according to claim 1, wherein the moisturizer further comprises one or a mixture of more than two of hydroxypropyl trimethyl ammonium chloride hyaluronic acid, a sodium hyaluronate crosspolymer, hydrolyzed sodium hyaluronate and hyaluronic acid.
7. The skin care essence according to claim 1, wherein the moisture preserving agent comprises one or a mixture of two or more of 1, 2-hexanediol and 1, 2-pentanediol.
8. The skin care essence according to claim 1, wherein the moisturizing preservative further comprises 1-2 parts by weight of ethylhexyl glycerin.
9. The skin care essence according to claim 1, wherein the solvent comprises water, butylene glycol, glycerin, 1, 3-propanediol and panthenol.
10. The preparation method of the skin care essence according to any one of claims 1 to 9, characterized by comprising the following steps:
(1) mixing the agave leaf extract, the neem leaf extract, the plant extract, the p-hydroxyacetophenone and the moisturizing preservative, heating to 80-85 ℃, preserving heat for 15-20 min, and uniformly stirring to obtain a mixed solution A;
(2) uniformly mixing glycerol glucoside, beta-glucan, retinol, a humectant and a solvent to obtain a mixed solution B;
(3) and mixing the mixed solution A and the mixed solution B at 80-85 ℃, uniformly stirring and homogenizing for 5min at the speed of 60r/min, preserving heat for 30-40 min, cooling to below 35 ℃, and filtering to obtain the soothing and moisturizing essence.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112190509A (en) * | 2020-09-11 | 2021-01-08 | 广州优理氏生物科技有限公司 | Composite plant extract and preparation method and application thereof |
| WO2021088399A1 (en) * | 2019-11-05 | 2021-05-14 | 湖北创界生物科技有限公司 | Moisturizing and hydrating facial mask composition, facial mask, and preparation method for facial mask composition |
| CN113332207A (en) * | 2021-05-26 | 2021-09-03 | 上海琦成化妆品有限公司 | Whitening face cleaning cream and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021088399A1 (en) * | 2019-11-05 | 2021-05-14 | 湖北创界生物科技有限公司 | Moisturizing and hydrating facial mask composition, facial mask, and preparation method for facial mask composition |
| CN112190509A (en) * | 2020-09-11 | 2021-01-08 | 广州优理氏生物科技有限公司 | Composite plant extract and preparation method and application thereof |
| CN113332207A (en) * | 2021-05-26 | 2021-09-03 | 上海琦成化妆品有限公司 | Whitening face cleaning cream and preparation method thereof |
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