CN115087731A - 用小化合物增强iPSC衍生的效应免疫细胞 - Google Patents

用小化合物增强iPSC衍生的效应免疫细胞 Download PDF

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CN115087731A
CN115087731A CN202080095636.2A CN202080095636A CN115087731A CN 115087731 A CN115087731 A CN 115087731A CN 202080095636 A CN202080095636 A CN 202080095636A CN 115087731 A CN115087731 A CN 115087731A
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cells
cell
derived
receptor
car
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B·瓦拉莫河
R·比乔戴尔
J·古德里奇
M·曼达尔
C·W·常
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Fate Therapeutics Inc
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Fate Therapeutics Inc
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CN202080095636.2A 2019-12-06 2020-12-04 用小化合物增强iPSC衍生的效应免疫细胞 Pending CN115087731A (zh)

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US201962945040P 2019-12-06 2019-12-06
US62/945,040 2019-12-06
PCT/US2020/063457 WO2021113744A1 (en) 2019-12-06 2020-12-04 Enhancement of ipsc-derived effector immune cell using small compounds

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US (1) US20230016034A1 (https=)
EP (1) EP4069827A4 (https=)
JP (1) JP2023505206A (https=)
KR (1) KR20220124179A (https=)
CN (1) CN115087731A (https=)
AU (1) AU2020395239A1 (https=)
BR (1) BR112022011072A2 (https=)
CA (1) CA3160423A1 (https=)
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Cited By (2)

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CN119220607A (zh) * 2024-12-03 2024-12-31 星奕昂(上海)生物科技有限公司 编辑tim3基因获得功能强化的car-nk细胞的方法与应用
CN121472143A (zh) * 2026-01-06 2026-02-06 南京医拓生物科技有限公司 高活化状态nk细胞富集型淋巴细胞的培养方法

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US11629340B2 (en) 2017-03-03 2023-04-18 Obsidian Therapeutics, Inc. DHFR tunable protein regulation
WO2022011065A1 (en) * 2020-07-07 2022-01-13 The Nemours Foundation Tumor-activated alloreactive and xenoreactive t cells and their use in immunotherapy against cancer
AR125851A1 (es) * 2021-05-12 2023-08-16 Crispr Therapeutics Ag Células inmunes modificadas genéticamente que se focalizan en cd70 para su uso en el tratamiento de neoplasias malignas hematopoyéticas
WO2022269393A1 (en) * 2021-06-23 2022-12-29 Crispr Therapeutics Ag Engineered cells with improved protection from natural killer cell killing
AU2022304599A1 (en) * 2021-07-02 2024-01-18 Fate Therapeutics, Inc. Protected effector cells and use thereof for allogeneic adoptive cell therapies
KR20240102994A (ko) * 2021-11-08 2024-07-03 페이트 세러퓨틱스, 인코포레이티드 고형 종양의 유비쿼터스 표적화를 향상시키는 조작된 이펙터 세포 및 방법
TW202340453A (zh) * 2022-01-28 2023-10-16 中國大陸商杭州啟函生物科技有限公司 用於基於細胞的免疫療法的方法和組合物
US20250222029A1 (en) 2022-04-08 2025-07-10 Fate Therapeutics, Inc. Chimeric antigen receptor for tumor targeting
US20250228943A1 (en) * 2022-04-08 2025-07-17 Fate Therapeutics, Inc. Cells having solid tumor targeting backbone and use thereof
WO2024097911A1 (en) * 2022-11-02 2024-05-10 Fate Therapeutics, Inc. Off-the-shelf therapeutic cells with multiplex genomic engineering for targeting gprc5d
WO2024102704A2 (en) * 2022-11-07 2024-05-16 Fate Therapeutics, Inc. Ipsc-derived nk cell targeting mica/b for solid tumor treatment
WO2025104248A1 (en) * 2023-11-17 2025-05-22 Repairon Immuno Gmbh Method of producing an immune cell devoid of endogenous effector functions from pluripotent stem cells
CN117305241B (zh) * 2023-11-28 2024-03-19 上海兴瑞一达生物科技有限公司 一种hiPSCs诱导分化为NK细胞的方法
WO2025217183A1 (en) * 2024-04-09 2025-10-16 Board Of Regents, The University Of Texas System Prepared natural killer cells and uses thereof

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CN108495641A (zh) * 2015-08-11 2018-09-04 塞勒克提斯公司 用于靶向cd38抗原和用于cd38基因失活的工程化的用于免疫疗法的细胞
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CN108368520A (zh) * 2015-11-04 2018-08-03 菲特治疗公司 多能细胞的基因组工程改造
WO2019018603A2 (en) * 2017-07-19 2019-01-24 Fate Therapeutics, Inc. COMPOSITIONS AND METHODS FOR MODULATION OF IMMUNE CELLS IN ADOPTIVE IMMUNOTHERAPIES
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119220607A (zh) * 2024-12-03 2024-12-31 星奕昂(上海)生物科技有限公司 编辑tim3基因获得功能强化的car-nk细胞的方法与应用
CN119220607B (zh) * 2024-12-03 2025-03-07 星奕昂(上海)生物科技有限公司 编辑tim3基因获得功能强化的car-nk细胞的方法与应用
CN121472143A (zh) * 2026-01-06 2026-02-06 南京医拓生物科技有限公司 高活化状态nk细胞富集型淋巴细胞的培养方法

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JP2023505206A (ja) 2023-02-08
KR20220124179A (ko) 2022-09-13
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CA3160423A1 (en) 2021-06-10
EP4069827A1 (en) 2022-10-12
BR112022011072A2 (pt) 2022-08-23
US20230016034A1 (en) 2023-01-19
WO2021113744A1 (en) 2021-06-10
MX2022006725A (es) 2022-08-22
IL293564A (en) 2022-08-01

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