CN115068364A - Low-irritation color-changing whitening and moisturizing essence and preparation method thereof - Google Patents
Low-irritation color-changing whitening and moisturizing essence and preparation method thereof Download PDFInfo
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- CN115068364A CN115068364A CN202210452329.6A CN202210452329A CN115068364A CN 115068364 A CN115068364 A CN 115068364A CN 202210452329 A CN202210452329 A CN 202210452329A CN 115068364 A CN115068364 A CN 115068364A
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- 230000002087 whitening effect Effects 0.000 title claims abstract description 50
- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 49
- 238000002360 preparation method Methods 0.000 title claims abstract description 26
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 88
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 55
- 239000000203 mixture Substances 0.000 claims abstract description 27
- 235000010323 ascorbic acid Nutrition 0.000 claims abstract description 20
- 239000011668 ascorbic acid Substances 0.000 claims abstract description 20
- 229960005070 ascorbic acid Drugs 0.000 claims abstract description 20
- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical compound [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 claims abstract description 19
- 229940108925 copper gluconate Drugs 0.000 claims abstract description 19
- 238000001816 cooling Methods 0.000 claims abstract description 10
- 230000003750 conditioning effect Effects 0.000 claims abstract description 5
- 238000002156 mixing Methods 0.000 claims abstract description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 26
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 25
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 25
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 25
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 24
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 22
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 20
- 238000003756 stirring Methods 0.000 claims description 15
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 10
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 10
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 10
- 229910052708 sodium Inorganic materials 0.000 claims description 10
- 239000011734 sodium Substances 0.000 claims description 10
- 229940104261 taurate Drugs 0.000 claims description 10
- FCGXLCNBWYIEAA-UHFFFAOYSA-N 1,3-benzothiazol-6-ylmethanamine Chemical compound NCC1=CC=C2N=CSC2=C1 FCGXLCNBWYIEAA-UHFFFAOYSA-N 0.000 claims description 8
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 claims description 8
- SWQUTKGVXGTROS-UHFFFAOYSA-N bis(2-ethoxyethyl) butanedioate Chemical compound CCOCCOC(=O)CCC(=O)OCCOCC SWQUTKGVXGTROS-UHFFFAOYSA-N 0.000 claims description 8
- 229940119676 diethoxyethyl succinate Drugs 0.000 claims description 8
- -1 dimethyl taurate Chemical compound 0.000 claims description 8
- 235000011187 glycerol Nutrition 0.000 claims description 8
- 229940089468 hydroxyethylpiperazine ethane sulfonic acid Drugs 0.000 claims description 8
- 239000001509 sodium citrate Substances 0.000 claims description 8
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 238000002845 discoloration Methods 0.000 claims description 4
- 239000003906 humectant Substances 0.000 claims description 4
- 230000000149 penetrating effect Effects 0.000 claims description 4
- 239000003755 preservative agent Substances 0.000 claims description 4
- 230000002335 preservative effect Effects 0.000 claims description 4
- 239000002562 thickening agent Substances 0.000 claims description 4
- 238000007599 discharging Methods 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 230000014759 maintenance of location Effects 0.000 claims description 2
- 230000036961 partial effect Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 9
- 230000007794 irritation Effects 0.000 abstract description 9
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract description 3
- 238000005282 brightening Methods 0.000 abstract description 3
- 229910052802 copper Inorganic materials 0.000 abstract description 3
- 239000010949 copper Substances 0.000 abstract description 3
- MLSJBGYKDYSOAE-DCWMUDTNSA-N L-Ascorbic acid-2-glucoside Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1O MLSJBGYKDYSOAE-DCWMUDTNSA-N 0.000 abstract description 2
- 229940067599 ascorbyl glucoside Drugs 0.000 abstract description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 8
- 229930003268 Vitamin C Natural products 0.000 description 8
- 235000019154 vitamin C Nutrition 0.000 description 8
- 239000011718 vitamin C Substances 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 6
- 239000002537 cosmetic Substances 0.000 description 6
- 239000008367 deionised water Substances 0.000 description 6
- 229910021641 deionized water Inorganic materials 0.000 description 6
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 6
- 230000001804 emulsifying effect Effects 0.000 description 5
- 230000000638 stimulation Effects 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000012496 blank sample Substances 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 150000003700 vitamin C derivatives Chemical class 0.000 description 2
- DBSABEYSGXPBTA-RXSVEWSESA-N (2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;phosphoric acid Chemical compound OP(O)(O)=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O DBSABEYSGXPBTA-RXSVEWSESA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Natural products CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 1
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 1
- 102000005348 Neuraminidase Human genes 0.000 description 1
- 108010006232 Neuraminidase Proteins 0.000 description 1
- 206010042496 Sunburn Diseases 0.000 description 1
- 102000003425 Tyrosinase Human genes 0.000 description 1
- 108060008724 Tyrosinase Proteins 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 235000010385 ascorbyl palmitate Nutrition 0.000 description 1
- 229940071097 ascorbyl phosphate Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000003711 chorioallantoic membrane Anatomy 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000002433 hydrophilic molecules Chemical class 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/88—Two- or multipart kits
- A61K2800/882—Mixing prior to application
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a low-irritation color-changing whitening and moisturizing essence and a preparation method thereof, and belongs to the technical field of skin care products. The essence is formed by mixing and reacting a first component and a second component which are separately placed, wherein the first component comprises copper gluconate, an agent A containing a moisturizing component, an agent B containing a conditioning component and a pH adjusting component D, and the second component is ascorbic acid; when the first component is prepared, the agent A, the agent B, the copper gluconate and the agent D are sequentially added according to the cooling sequence to form a mixture, and finally the mixture is uniformly mixed with the second component which is independently placed before use, and the nano copper and the ascorbyl glucoside are formed by the reaction of the copper gluconate and the ascorbic acid, so that the finally formed essence is convenient to use, small in irritation, and remarkable in whitening and skin color brightening effects.
Description
Technical Field
The invention relates to an essence and a preparation method thereof, in particular to a low-irritation color-changing essence and a preparation method thereof, and belongs to the technical field of skin care products.
Background
With the development of the times, more and more women do not choose cosmetics with a covering effect to achieve the whitening effect, but more and more select proper skin care products and combine healthy work and rest in daily life to achieve natural, healthy, uniform, white and pure skin color. The common skin care products generally comprise whitening and moisturizing cream and/or milk, whitening and moisturizing essence and the like, wherein the essence is favored by skin care enthusiasts due to the unique characteristics of high concentration and quick penetration.
Ascorbic acid is also commonly known as vitamin C, has the effects of capturing free oxygen radicals, reducing melanin, inhibiting the formation of tyrosinase and promoting the synthesis of collagen in the cosmetic industry, and can effectively strengthen the capability of skin on resisting sunburn so as to achieve the effects of whitening, lightening spots and resisting aging, so that the ascorbic acid is an important raw material in the cosmetic industry all the time, is added and applied to a plurality of products, and is a preferred raw material of a plurality of brands.
However, pure vitamin C is not suitable for being directly added into cosmetics because its strong oxidation resistance easily causes oxygen to be oxidized when contacting air; in addition, the hydrophilic molecules of the pure vitamin C added into the liquid cosmetic are difficult to be absorbed by the skin of a human body, can only stay outside the skin, and can be oxidized after long-time stay, so that the pure vitamin C does not play a due role; in addition, the pure vitamin C has large irritation to human skin, and the phenomenon of red swelling, stabbing pain and the like of facial skin caused by uncomfortable arrangement when the pure vitamin C is used, and particularly, the problem is easily caused by the use of high-concentration pure vitamin C. In the prior art, derivatives of vitamin C, such as ascorbyl phosphate, ascorbyl palmitate, ascorbyl ethyl ether, etc., are used as whitening components, and although the stability of these vitamin C derivatives is higher than that of pure vitamin C, the use effect after long-term storage may be poor.
Disclosure of Invention
In order to solve the technical problems, the invention provides the low-irritation color-changing whitening and moisturizing essence and the preparation method thereof, and the prepared essence can be used immediately and has low irritation.
The technical scheme of the invention is as follows:
the invention discloses a low-irritation discoloring whitening and moisturizing essence which is formed by mixing and reacting a first component and a second component which are separately placed, wherein the first component comprises copper gluconate (agent C), an agent A containing a moisturizing component, an agent B containing a conditioning component and a pH adjusting component agent D; wherein the second component is ascorbic acid (agent E).
The further technical scheme is as follows:
the copper gluconate accounts for 0.3-5.0 wt% of the total amount of the low-irritation, color-changing, whitening and moisturizing essence, and the ascorbic acid accounts for 1.0-5.0 wt% of the total amount of the low-irritation, color-changing, whitening and moisturizing essence.
The further technical scheme is as follows:
the agent A in the first component comprises hydrolyzed sodium hyaluronate, an alcohol humectant, a penetrating agent, a thickening agent, a preservative and water, wherein the hydrolyzed sodium hyaluronate and the sodium hyaluronate respectively account for 0.01-0.2 wt.% and 0.05-0.2 wt.% of the total amount of the low-irritation discoloring, whitening and moisturizing essence. Preferably, the sodium hyaluronate has a weight average molecular weight of 130w-150 w.
The further technical scheme is as follows:
the alcohol humectant comprises 1, 3-butanediol and 1, 2-hexanediol, the penetrating agent comprises isosorbide dimethyl ether, the thickening agent comprises sodium polyacryl dimethyl taurate, and the preservative comprises p-hydroxyacetophenone.
The further technical scheme is as follows:
the 1, 3-butanediol is used in an amount of 2.0-8.0 wt.%; 1, 2-hexanediol in an amount of 0.5-1.5 wt.%; the dimethyl isosorbide anhydride is used in an amount of 1.0-5.0 wt.%; the usage amount of sodium polyacryloyl dimethyl taurate is 0.3-0.8 wt.%; the usage amount of the p-hydroxyacetophenone is 0.2-0.4 wt.%, the usage amount of the water is 70.4-93.0 wt.%, and the usage amounts of the components are the mass percentages of the components respectively accounting for the total amount of the low-irritation discoloration, whitening and moisturizing essence.
The further technical scheme is as follows:
the conditioning component of the agent B in the first component comprises 0.5-1.0 wt.% of PEG/PPG/polytetramethylene glycol-8/5/3 glycerin, 0.2-0.5 wt.% of diethoxyethyl succinate and 0.3-1.0 wt.% of hydroxyethyl piperazine ethane sulfonic acid, and the dosage of each component is the mass percentage of the total amount of the low-irritation discoloring, whitening and moisturizing essence respectively.
The further technical scheme is as follows:
the pH adjusting component of the agent D in the first component comprises citric acid with the dosage of 0.00001-0.01 wt.% and sodium citrate with the dosage of 0.5-1.0 wt.%, and the dosages of the components are the mass percentages of the components respectively accounting for the total amount of the low-irritation discoloration, whitening and moisturizing essence.
The further technical scheme is as follows:
the second component accounts for 1.0-5.0 wt% of the total amount of the low-irritation, color-changing, whitening and moisturizing essence.
The further technical scheme is as follows:
the low-irritation discoloring whitening and moisturizing essence comprises the following components in percentage by mass:
an agent A: deionized water 70.4-93.0 wt.%, isosorbide dimethyl ether 1-5 wt.%, 1, 3-butanediol 2-8 wt.%, hydrolyzed sodium hyaluronate 0.01-0.2 wt.%, p-hydroxyacetophenone 0.2-0.4 wt.%, 1, 2-hexanediol 0.5-1.5 wt.%, sodium hyaluronate 0.05-0.2 wt.% having a weight average molecular weight of 130w-150w, and sodium polyacryloyldimethyl taurate 0.3-0.8 wt.%.
And (2) agent B: PEG/PPG/polytetramethylene glycol-8/5/3 glycerol 0.5-1.0 wt.%; diethoxyethyl succinate 0.2-0.5 wt.%; 0.3-1.0 wt.% of hydroxyethylpiperazine ethanesulfonic acid.
C, agent C: copper gluconate 0.3-5.0 wt.%.
And (2) agent D: citric acid 0.00001-0.01 wt.%; sodium citrate 0.5-1.0 wt.%.
E, an agent: ascorbic acid 1.0-5.0 wt.%.
The invention also discloses a preparation method of the low-irritation discoloring whitening and moisturizing essence, which mainly comprises the following steps:
preparation of agent A mixture: premixing partial moisture retention components in the agent A, adding the rest agent A, heating at 75-85 deg.C while stirring to form agent A mixture, and keeping the temperature for use;
preparation of the mixture of agents B: heating all the raw materials of the agent B at 30-40 ℃ and stirring uniformly to form an agent B mixture, and keeping the temperature for later use;
preparation of the first type of component: cooling the mixture of the agent A to 55-65 ℃, slowly adding the mixture of the agent B, and uniformly stirring; continuously cooling to 40-50 ℃, slowly adding copper gluconate, and keeping the temperature and stirring uniformly; then cooling to 35-40 ℃, slowly adding the agent D, preserving heat, uniformly stirring, and discharging to form a first type of component;
preparation of the second type of component: shaking ascorbic acid separately to form a second component;
and (3) preparing a finished product: the first component and the second component are separately placed according to a certain proportion, and are uniformly mixed until the blue color is changed into yellow mixed liquid before use, so that the low-irritation color-changing, whitening and moisturizing essence is formed.
The further technical scheme is as follows:
in the preparation step of the agent A mixture, part of the moisturizing components in the agent A are 1, 3-butanediol, hydrolyzed sodium hyaluronate and sodium hyaluronate.
The beneficial technical effects of the invention are as follows:
the copper gluconate and the ascorbic acid which are separately placed are mixed for reduction reaction before use, so that the nano copper and the ascorbic acid glucoside which are uniformly dispersed in an essence system can be generated. Wherein the generated ascorbyl glucoside has whitening and anti-oxidation effects, and simultaneously, the irritation to the skin is greatly reduced; the produced nano copper has the functions of inhibiting the activity of the neuraminidase, eliminating oxidation substances, blocking the formation of melanin and brightening the skin, and also has the functions of resisting bacteria and diminishing inflammation. The prepared essence is convenient to use, has small irritation, and has remarkable effects of whitening and brightening skin.
Detailed Description
In order to clearly understand the technical means of the present invention and to implement the technical means according to the content of the specification, the following embodiments and comparative examples are further described in detail, and the following examples and comparative examples are only used to illustrate the technical solution of the present invention, but not to limit the scope of the present invention.
The formulation of the essence of the present invention was performed according to the following formulation described in specific examples 1 to 5.
Detailed description of the preferred embodiment 1
An agent A: 88.48 wt.% deionized water; isosorbide dimethyl ether 2.0 wt.%; 1, 3-butanediol 4.0 wt.%; 0.05 wt.% hydrolyzed sodium hyaluronate; 0.3 wt.% p-hydroxyacetophenone; 1, 2-hexanediol, 1.0 wt.%; 0.1 wt.% sodium hyaluronate (weight average molecular weight 130w-150 w); sodium polyacryloyldimethyl taurate 0.5 wt.%.
And (2) agent B: PEG/PPG/polytetramethylene glycol-8/5/3 glycerol 0.8 wt.%; diethoxyethyl succinate 0.3 wt.%; 0.5 wt.% of hydroxyethylpiperazine ethanesulfonic acid.
And (C) agent: copper gluconate 0.3 wt.%.
And (3) agent D: citric acid 0.00001 wt.%; sodium citrate 0.67 wt.%.
E, an agent: ascorbic acid 1 wt.%.
Specific example 2
An agent A: 84.195 wt.% deionized water; isosorbide dimethyl ether 3.0 wt.%; 6.0 wt.% 1, 3-butanediol; 0.1 wt.% hydrolyzed sodium hyaluronate; 0.4 wt.% p-hydroxyacetophenone; 1, 2-hexanediol, 1.5 wt.%; 0.2 wt.% sodium hyaluronate (weight average molecular weight 130w-150 w); sodium polyacryloyldimethyl taurate 0.53 wt.%.
And (2) agent B: PEG/PPG/polytetramethylene glycol-8/5/3 glycerol 1.0 wt.%; diethoxyethyl succinate 0.5 wt.%; 0.8 wt.% of hydroxyethylpiperazine ethanesulfonic acid.
C, agent C: copper gluconate 1.0 wt.%.
And (2) agent D: citric acid 0.005 wt.%; sodium citrate 0.5 wt.%.
E, an agent: ascorbic acid 1.5 wt.%.
Specific example 3
An agent A: 82.93 wt.% deionized water; isosorbide dimethyl ether 5.0 wt.%; 1, 3-butanediol 2.0 wt.%; 0.01 wt.% hydrolyzed sodium hyaluronate; 0.2 percent of p-hydroxyacetophenone; 1, 2-hexanediol, 1.5 wt.%; sodium hyaluronate (weight average molecular weight 130w-150w)0.05 wt.%; sodium polyacryloyldimethyl taurate 0.8 wt.%.
And (2) agent B: PEG/PPG/polytetramethylene glycol-8/5/3 glycerol 0.5 wt.%; diethoxyethyl succinate 0.2 wt.%; 1.0 wt.% of hydroxyethylpiperazine ethanesulfonic acid.
And (C) agent: copper gluconate 3.0 wt.%.
And (3) agent D: citric acid 0.01 wt.%; sodium citrate 0.8 wt.%.
E, an agent: ascorbic acid 2.0 wt.%.
Specific example 4
A, an agent: 79.547 wt.% deionized water; isosorbide dimethyl ether 1.0 wt.%; 8.0 wt.% 1, 3-butanediol; 0.2 wt.% hydrolyzed sodium hyaluronate; 0.3 wt.% p-hydroxyacetophenone; 1, 2-hexanediol, 1.2 wt.%; 0.15 wt.% sodium hyaluronate (weight average molecular weight 130w-150 w); sodium polyacryloyldimethyl taurate 0.6 wt.%.
And (2) agent B: PEG/PPG/polytetramethylene glycol-8/5/3 glycerol 0.8 wt.%; diethoxyethyl succinate 0.4 wt.%; 0.3 wt.% of hydroxyethylpiperazine ethanesulfonic acid.
C, agent C: copper gluconate 5.0 wt.%.
And (3) agent D: citric acid 0.003 wt.%; sodium citrate 1.0 wt.%.
E, an agent: ascorbic acid 1.5 wt.%.
Specific example 5
An agent A: 79.398 wt.% deionized water; isosorbide dimethyl ether 3.0 wt.%; 1, 3-butanediol 4.0 wt.%; 0.05 wt.% hydrolyzed sodium hyaluronate; 0.3 wt.% p-hydroxyacetophenone; 1, 2-hexanediol, 1.0 wt.%; 0.15 wt.% sodium hyaluronate (weight average molecular weight 130w-150 w); sodium polyacryloyldimethyl taurate 0.6 wt.%.
And (2) agent B: PEG/PPG/polytetramethylene glycol-8/5/3 glycerol 0.7 wt.%; diethoxyethyl succinate 0.3 wt.%; 0.5 wt.% of hydroxyethylpiperazine ethanesulfonic acid.
C, agent C: copper gluconate 4.5 wt.%.
And (3) agent D: citric acid 0.002 wt.%; sodium citrate 0.5 wt.%.
E, an agent: ascorbic acid 5.0 wt.%.
The components of the essence described in the above specific examples 1 to 5 were prepared according to the following preparation methods, respectively, which mainly included the following steps:
a preparation method of low-irritation discoloring whitening moisturizing essence mainly comprises the following steps:
preparation of agent A mixture: premixing 1, 3-butanediol, hydrolyzed sodium hyaluronate and sodium hyaluronate in the agent A uniformly in an emulsifying pot, adding the rest agent A component into the emulsifying pot, heating at 75-85 ℃, uniformly stirring to form an agent A mixture, and keeping the temperature for later use;
preparation of the mixture of agents B: heating all the raw materials of the agent B at 30-40 ℃ and stirring uniformly to form an agent B mixture, and keeping the temperature for later use;
preparation of the first type of component: cooling the mixture of the agent A in the emulsifying pot to 55-65 ℃, slowly adding the mixture of the agent B, and uniformly stirring; continuously cooling the materials in the emulsifying pot to 40-50 ℃, slowly adding copper gluconate, and uniformly stirring while keeping the temperature; then cooling the materials in the emulsifying pot to 35-40 ℃, slowly adding the agent D, preserving heat, uniformly stirring, and discharging to form a first type of component;
preparation of the second type of component: shaking ascorbic acid separately to form a second component;
and (3) preparing a finished product: the first component is filled in the lower half layer of the double-layer bottle, the second component is separately filled in the upper half layer of the double-layer bottle, the first component and the second component are uniformly mixed through external force action such as up-and-down shaking and the like before use, at the moment, the color of the material is changed from blue of the first component to yellow of the mixture of the first component and the second component, and the low-irritation color-changing whitening moisturizing essence A, B, C, D and E are formed.
Meanwhile, the comparative essence is prepared according to the following material proportion and preparation method respectively.
Comparative example 1
The formulation is as in example 1, but without the use of agent C (copper gluconate). The resulting serum was prepared as blank 1. The blank is prepared according to the preparation method, and the steps related to the copper gluconate are removed or omitted.
The essence A-E prepared in the specific examples and the blank sample 1 prepared in the comparative example are subjected to a irritation test, the test method is carried out in the national standard SN/T2329-chick embryo chorioallantoic membrane test for irritation/corrosiveness of cosmetic eyes 2009, and the ES endpoint evaluation method is adopted for evaluation. The test results are described in the following table.
TABLE 1 results of irritation tests of specific examples and comparative examples
As can be seen from the test results shown in table 1 above, when only ascorbic acid was used as a main ingredient for whitening in the same formulation system, although the stimulation level was mild stimulation, the total ES score was 11 points, almost reaching the boundary of moderate stimulation, and the average score was as high as 1.83 points. The essence prepared by the preparation method has the stimulation grade of slight stimulation, but the total ES score is 6-8, the average ES score is 1-1.33, and the irritation is lower than that of a blank sample.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, it should be noted that, for those skilled in the art, many modifications and variations can be made without departing from the technical principle of the present invention, and these modifications and variations should also be regarded as the protection scope of the present invention.
Claims (10)
1. The low-irritation color-changing whitening moisturizing essence is characterized in that: the water-based moisturizing agent is formed by mixing and reacting a first component and a second component which are separately placed, wherein the first component comprises copper gluconate, an agent A containing a moisturizing component, an agent B containing a conditioning component and a pH adjusting component D; wherein the second component is ascorbic acid.
2. The low-irritation discoloring whitening and moisturizing essence as claimed in claim 1, wherein the low-irritation discoloring whitening and moisturizing essence comprises: the copper gluconate accounts for 0.3-5.0 wt% of the total amount of the low-irritation, color-changing, whitening and moisturizing essence, and the ascorbic acid accounts for 1.0-5.0 wt% of the total amount of the low-irritation, color-changing, whitening and moisturizing essence.
3. The low-irritation discoloring whitening and moisturizing essence as claimed in claim 1, wherein the low-irritation discoloring whitening and moisturizing essence comprises: the agent A in the first component comprises hydrolyzed sodium hyaluronate, an alcohol humectant, a penetrating agent, a thickening agent, a preservative and water, wherein the hydrolyzed sodium hyaluronate and the sodium hyaluronate respectively account for 0.01-0.2 wt.% and 0.05-0.2 wt.% of the total amount of the low-irritation discoloring whitening and moisturizing essence.
4. The low-irritation discoloring whitening and moisturizing essence as claimed in claim 3, wherein the low-irritation discoloring whitening and moisturizing essence comprises the following components in percentage by weight: the alcohol humectant comprises 1, 3-butanediol and 1, 2-hexanediol, the penetrating agent comprises isosorbide dimethyl ether, the thickening agent comprises sodium polyacryl dimethyl taurate, and the preservative comprises p-hydroxyacetophenone.
5. The low-irritation discoloring whitening and moisturizing essence as claimed in claim 4, wherein the low-irritation discoloring whitening and moisturizing essence comprises the following components in percentage by weight: the 1, 3-butanediol is used in an amount of 2.0-8.0 wt.%; 1, 2-hexanediol in an amount of 0.5-1.5 wt.%; the dimethyl isosorbide anhydride is used in an amount of 1.0-5.0 wt.%; sodium polyacryl dimethyl taurate is used in an amount of 0.3 to 0.8 wt.%; the usage amount of the p-hydroxyacetophenone is 0.2-0.4 wt.%, the usage amount of the water is 70.4-93.0 wt.%, and the usage amounts of the components are the mass percentages of the components respectively accounting for the total amount of the low-irritation discoloration, whitening and moisturizing essence.
6. The low-irritation discoloring whitening and moisturizing essence as claimed in claim 1, wherein the low-irritation discoloring whitening and moisturizing essence comprises: the conditioning component of the agent B in the first component comprises 0.5-1.0 wt.% of PEG/PPG/polytetramethylene glycol-8/5/3 glycerin, 0.2-0.5 wt.% of diethoxyethyl succinate and 0.3-1.0 wt.% of hydroxyethyl piperazine ethane sulfonic acid, and the using amounts of the components are mass percentages of the total amount of the low-irritation discoloring, whitening and moisturizing essence respectively.
7. The low-irritation discoloring whitening and moisturizing essence as claimed in claim 1, wherein the low-irritation discoloring whitening and moisturizing essence comprises: the pH adjusting component of the agent D in the first component comprises citric acid with the dosage of 0.00001-0.01 wt.% and sodium citrate with the dosage of 0.5-1.0 wt.%, and the dosages of the components are the mass percentages of the components respectively accounting for the total amount of the low-irritation discoloration, whitening and moisturizing essence.
8. The low-irritation discoloring whitening and moisturizing essence as claimed in claim 1, wherein the low-irritation discoloring whitening and moisturizing essence comprises: the second component accounts for 1.0-5.0 wt% of the total amount of the low-irritation color-changing, whitening and moisturizing essence.
9. The preparation method of the low-irritation discoloring whitening and moisturizing essence as claimed in any one of claims 1 to 8, which is characterized by mainly comprising the following steps of:
preparation of agent A mixture: premixing partial moisture retention components in the agent A, adding the rest agent A, heating at 75-85 deg.C while stirring to form agent A mixture, and keeping the temperature for use;
preparation of the mixture of agents B: heating all the raw materials of the agent B at 30-40 ℃ and stirring uniformly to form an agent B mixture, and keeping the temperature for later use;
preparation of the first type of component: cooling the mixture of the agent A to 55-65 ℃, slowly adding the mixture of the agent B, and uniformly stirring; continuously cooling to 40-50 ℃, slowly adding copper gluconate, and keeping the temperature and stirring uniformly; then cooling to 35-40 ℃, slowly adding the agent D, preserving heat, uniformly stirring, and discharging to form a first type of component;
preparation of the second type of component: shaking ascorbic acid separately to form a second component;
preparing a finished product: the first component and the second component are separately placed according to a proportion, and are uniformly mixed until the blue color is changed into yellow mixed liquid before use, so that the low-irritation color-changing whitening and moisturizing essence is formed.
10. The method of claim 9, wherein in the step of preparing the mixture of the agent A, the moisturizing components of the agent A are 1, 3-butanediol, hydrolyzed sodium hyaluronate and sodium hyaluronate.
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| CN103923136A (en) * | 2014-04-20 | 2014-07-16 | 厦门世达膜科技有限公司 | Production method of ascorbyl glucoside |
| KR20150121409A (en) * | 2014-04-21 | 2015-10-29 | (주)아모레퍼시픽 | Method for stabilizing ascorbic acid 2-glucoside and a cosmetic composition containing the stabilized ascorbic acid 2-glucoside |
| CN111671716A (en) * | 2020-07-22 | 2020-09-18 | 广州蛋壳网络科技有限公司 | Antioxidant skin color brightening composition and application thereof in cosmetics |
| CN112618466A (en) * | 2021-02-15 | 2021-04-09 | 广州小兔科技有限公司 | Whitening and moisturizing emulsion and preparation method thereof |
| CN113398000A (en) * | 2021-06-21 | 2021-09-17 | 广州易和生物科技有限公司 | Dual-agent color-changing whitening essence and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103923136A (en) * | 2014-04-20 | 2014-07-16 | 厦门世达膜科技有限公司 | Production method of ascorbyl glucoside |
| KR20150121409A (en) * | 2014-04-21 | 2015-10-29 | (주)아모레퍼시픽 | Method for stabilizing ascorbic acid 2-glucoside and a cosmetic composition containing the stabilized ascorbic acid 2-glucoside |
| CN111671716A (en) * | 2020-07-22 | 2020-09-18 | 广州蛋壳网络科技有限公司 | Antioxidant skin color brightening composition and application thereof in cosmetics |
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