CN115066235A - 包含泛素特异性加工蛋白酶1(usp1)抑制剂和多聚(adp-核糖)聚合酶(parp)抑制剂的治疗组合 - Google Patents

包含泛素特异性加工蛋白酶1(usp1)抑制剂和多聚(adp-核糖)聚合酶(parp)抑制剂的治疗组合 Download PDF

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Publication number
CN115066235A
CN115066235A CN202180013564.7A CN202180013564A CN115066235A CN 115066235 A CN115066235 A CN 115066235A CN 202180013564 A CN202180013564 A CN 202180013564A CN 115066235 A CN115066235 A CN 115066235A
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cancer
inhibitor
usp1
parp
pharmaceutically acceptable
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Chinese (zh)
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安德鲁·阿利斯泰尔·维利
所罗门·马丁·申克
帕梅拉·吉恩·沙利文
弗兰克·斯特格迈尔
安妮·路易丝·卡佐
刘涵兰
克斯廷·沃尔夫·辛克维丘斯
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Ksq Treatment Co
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Ksq Treatment Co
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN202180013564.7A 2020-02-14 2021-02-12 包含泛素特异性加工蛋白酶1(usp1)抑制剂和多聚(adp-核糖)聚合酶(parp)抑制剂的治疗组合 Pending CN115066235A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202062976864P 2020-02-14 2020-02-14
US62/976,864 2020-02-14
US202063032245P 2020-05-29 2020-05-29
US63/032,245 2020-05-29
US202163146937P 2021-02-08 2021-02-08
US63/146,937 2021-02-08
PCT/US2021/017912 WO2021163530A1 (en) 2020-02-14 2021-02-12 Therapeutic combinations comprising ubiquitin-specific-processing protease 1 (usp1) inhibitors and poly (adp-ribose) polymerase (parp) inhibitors

Publications (1)

Publication Number Publication Date
CN115066235A true CN115066235A (zh) 2022-09-16

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CN202180013564.7A Pending CN115066235A (zh) 2020-02-14 2021-02-12 包含泛素特异性加工蛋白酶1(usp1)抑制剂和多聚(adp-核糖)聚合酶(parp)抑制剂的治疗组合

Country Status (11)

Country Link
US (1) US20230277533A1 (enExample)
EP (1) EP4103165A4 (enExample)
JP (1) JP2023514568A (enExample)
KR (1) KR20220140732A (enExample)
CN (1) CN115066235A (enExample)
AU (1) AU2021218805A1 (enExample)
CA (1) CA3168009A1 (enExample)
IL (1) IL295149A (enExample)
MX (1) MX2022009818A (enExample)
TW (1) TW202140026A (enExample)
WO (1) WO2021163530A1 (enExample)

Cited By (4)

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CN117384187A (zh) * 2022-09-30 2024-01-12 轩竹生物科技股份有限公司 泛素特异性蛋白酶1抑制剂
WO2025087460A1 (zh) * 2023-10-25 2025-05-01 海思科医药集团股份有限公司 一种吡啶并吡唑衍生物药物组合物及其应用
WO2025153067A1 (zh) * 2024-01-19 2025-07-24 江苏亚虹医药科技股份有限公司 Usp1抑制剂及其医药用途
WO2025180502A1 (zh) * 2024-03-01 2025-09-04 上海齐鲁制药研究中心有限公司 一种联合用药物组合物及其用途

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EP4236958A4 (en) 2020-10-30 2024-09-11 KSQ Therapeutics, Inc. SOLID STATE FORMS OF SUBSTITUTED PYRAZOLOPYRIMIDINES AND THEIR USES
JP2024540921A (ja) * 2021-10-19 2024-11-06 上海瑛派▲薬▼▲業▼有限公司 Ｕｓｐ１阻害剤としての置換トリアゾロヘテロアリール化合物及びその応用
KR20240117556A (ko) * 2021-11-12 2024-08-01 인실리코 메디신 아이피 리미티드 유비퀴틴 특이적 프로테아제 1(usp1)의 소분자 억제제 및 이의 용도
CR20240190A (es) * 2021-11-12 2024-09-13 Insilico Medicine Ip Ltd Inhibidores de moléculas pequeñas de la proteasa específica de ubiquitina 1 (usp1) y sus usos
JP2025503139A (ja) * 2022-01-25 2025-01-30 ケーエスキュー セラピューティクス， インコーポレイテッド 固形腫瘍の治療のためのユビキチン特異的プロセシングプロテアーゼ１（ｕｓｐ１）阻害剤
JP2025531133A (ja) * 2022-09-20 2025-09-19 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド ユビキチン特異的プロテアーゼ阻害剤としてのカルボニル縮合複素環誘導体
AU2023347293A1 (en) * 2022-09-23 2025-04-10 KSQ Therapeutics, Inc. Therapeutic combinations comprising ubiquitin-specific-processing protease 1 (usp1) inhibitors and parp1-selective inhibitors
EP4605391A1 (en) 2022-10-21 2025-08-27 Exelixis, Inc. 4,5,6,7-tetrahydro-1-pyrazolo[4,3-c]pyridine compounds and derivatives as usp1 inhibitors
KR20260019479A (ko) 2023-05-04 2026-02-10 레볼루션 메디슨즈, 인크. Ras 관련 질환 또는 장애를 위한 병용 요법
TW202509030A (zh) 2023-05-08 2025-03-01 美商譚格醫療公司 化合物及使用方法
WO2024233665A1 (en) 2023-05-08 2024-11-14 Tango Therapeutics, Inc. Compounds and their use against cancer
JP2026521192A (ja) * 2023-06-16 2026-06-26 コリア・インスティテュート・オブ・サイエンス・アンド・テクノロジー ＢＲＣＡ特異的ｓｉＲＮＡを有効成分として含む標的癌予防又は治療用医薬組成物
EP4739397A1 (en) 2023-07-06 2026-05-13 Exelixis, Inc. Fused pyrazole derivatives as usp1 inhibitors
CN121889155A (zh) 2023-08-07 2026-04-17 锐新医药公司 用于治疗ras蛋白相关疾病或病症的rmc-6291
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AU2024378865A1 (en) 2023-11-10 2026-06-25 Vrise Therapeutics, Inc. Novel molecules as inhibitors of dna damage repair pathway
WO2025151705A1 (en) 2024-01-10 2025-07-17 Vrise Therapeutics, Inc. Novel inhibitors of dna damage repair pathway
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
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US20250375445A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
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Cited By (4)

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Publication number Priority date Publication date Assignee Title
CN117384187A (zh) * 2022-09-30 2024-01-12 轩竹生物科技股份有限公司 泛素特异性蛋白酶1抑制剂
WO2025087460A1 (zh) * 2023-10-25 2025-05-01 海思科医药集团股份有限公司 一种吡啶并吡唑衍生物药物组合物及其应用
WO2025153067A1 (zh) * 2024-01-19 2025-07-24 江苏亚虹医药科技股份有限公司 Usp1抑制剂及其医药用途
WO2025180502A1 (zh) * 2024-03-01 2025-09-04 上海齐鲁制药研究中心有限公司 一种联合用药物组合物及其用途

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TW202140026A (zh) 2021-11-01
WO2021163530A1 (en) 2021-08-19
KR20220140732A (ko) 2022-10-18
CA3168009A1 (en) 2021-08-19
US20230277533A1 (en) 2023-09-07
EP4103165A4 (en) 2024-02-28
EP4103165A1 (en) 2022-12-21
JP2023514568A (ja) 2023-04-06
AU2021218805A1 (en) 2022-09-01
MX2022009818A (es) 2022-09-05
IL295149A (en) 2022-09-01

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