CN115058289A - 高性能、高冲击强度的香味喷发谐香剂 - Google Patents
高性能、高冲击强度的香味喷发谐香剂 Download PDFInfo
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- CN115058289A CN115058289A CN202210864474.5A CN202210864474A CN115058289A CN 115058289 A CN115058289 A CN 115058289A CN 202210864474 A CN202210864474 A CN 202210864474A CN 115058289 A CN115058289 A CN 115058289A
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- 235000008210 xanthophylls Nutrition 0.000 description 1
- 150000003735 xanthophylls Chemical class 0.000 description 1
- ZFNVDHOSLNRHNN-UHFFFAOYSA-N xi-3-(4-Isopropylphenyl)-2-methylpropanal Chemical compound O=CC(C)CC1=CC=C(C(C)C)C=C1 ZFNVDHOSLNRHNN-UHFFFAOYSA-N 0.000 description 1
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- 201000009482 yaws Diseases 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 229960001939 zinc chloride Drugs 0.000 description 1
- 239000011746 zinc citrate Substances 0.000 description 1
- 235000006076 zinc citrate Nutrition 0.000 description 1
- 229940068475 zinc citrate Drugs 0.000 description 1
- 229940118827 zinc phenolsulfonate Drugs 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
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- 235000009529 zinc sulphate Nutrition 0.000 description 1
- BOVNWDGXGNVNQD-UHFFFAOYSA-L zinc;2-hydroxybenzenesulfonate Chemical compound [Zn+2].OC1=CC=CC=C1S([O-])(=O)=O.OC1=CC=CC=C1S([O-])(=O)=O BOVNWDGXGNVNQD-UHFFFAOYSA-L 0.000 description 1
- HZRFVTRTTXBHSE-AYJHFOLZSA-N α-cedrene epoxide Chemical compound C1[C@]23[C@H](C)CC[C@H]3C(C)(C)[C@@H]1C1(C)OC1C2 HZRFVTRTTXBHSE-AYJHFOLZSA-N 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- 229930007850 β-damascenone Natural products 0.000 description 1
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Abstract
本发明公开了各自含有以下成分的香精谐香剂:(i)至少7重量%的一种或多种1类香精成分,(ii)5至85重量%的一种或多种2类香精成分,和(iii)0至80重量%的一种或多种3类香精成分。所述1类、2类和3类香精成分通过实验速度限定。还公开了含有这样的香精谐香剂的递送系统和消费品。
Description
本申请是申请日为2017年10月16日、发明名称为“高性能、高冲击强度的香味喷发谐香剂”的中国专利申请No.201780062793.1的分案申请。
相关申请的交叉引用
本申请要求2016年10月14日提交的美国申请号62/408,350的优先权,该优先权申请的内容通过引用整体结合于此。
背景技术
所有已知的香精组合物包括至少一种香精谐香剂(其是香精化学品的特定组合),以及如果适用的话,用于产生不能由单一香精成分或精油产生的特定嗅觉气味的其他类型的原料。
香精组合物用于各种消费品中,以递送多种益处,其范围包括掩蔽令人不愉快的基质或恶臭、提供令人愉快的嗅觉美学益处、诱导消费者感觉(例如,快乐、刺激、放松等)和暗示产品属性和功能(例如,新鲜度、清洁度等)的信号。
已经尝试设计适合于特定产品应用的香精谐香剂和香精组合物,其具有优异或增强的性能,产生消费者利益。有许多出版物教导了基于它们的物理、化学、生物或感官特性选择这些香精成分。例如,WO 1999/065458将两类香精成分定义为基于沸点、分配系数(ClogP)和测量的气味检测阈值的组合配制成高冲击强度谐香剂。这些谐香剂可以任选地囊封在淀粉中,以在分散于水中时从洗涤剂粉末中提供增香。US 9,222,055提供了一种高强度香精,其包含75%至100%的至少两种关键香精成分,它们的沸点在760mmHg的压力下为100℃至300℃,分子量的范围为70原子质量单位至175原子质量单位,并且ClogP值为0至4。US 2005/0003975还公开了由高冲击强度谐香剂香料成分构成的香料组合物,所述成分通过沸点、计算的CLogP和气味检测阈值分类。EP 1 964 54描述了用于消费品中以减少过敏反应的香精组合物。WO 1997/034987公开了用于自动碗碟清洗洗涤剂组合物的香味喷发(blooming)香料组合物。
尽管进行了如上所述的许多尝试,但是仍需要设计高性能和高冲击强度的香味喷发香精谐香剂。
发明概述
本发明的一个方面提供了一种用于消费品(例如织物护理产品)的高强度香味喷发香精谐香剂,其含有:(i)至少7重量%(例如,7至95重量%)的1类香精成分,(ii)5至95重量%(例如,5至80重量%、10至80重量%和10至70重量%)的2类香精成分,和(iii)0至80重量%的3类香精成分,其中1类香精成分各自具有8.5cm/秒以上的实验速度,2类香精成分各自具有小于8.5cm/秒且大于5cm/秒的实验速度,并且3级香精成分各自具有5cm/秒以下的实验速度。
在一些实施方案中,高强度香味喷发香精谐香剂还含有有效中和恶臭的量的恶臭中和剂。在其他实施方案中,高强度香味喷发香精谐香剂不含选自1类、2类和3类成分的成分以外的成分。即,1类香精成分、2类香精成分和3类香精成分的总和为100%。
典型地,香精谐香剂包含至少两种(例如,至少三种、至少五种和至少七种)1类香精成分。
在一些实施方案中,香精谐香剂含有20至100重量%的1类和2类香精成分。
本发明的另一个方面涉及包含一种或多种上述香精谐香剂的递送系统。
含有按香味喷发香精组合物重量计5%以上(例如,6%以上、7%以上、10%以上和20%以上)的上述任何香精谐香剂的香味喷发香精组合物也在本发明的范围内。这些香精组合物典型地含有至少3%(例如,至少4%、至少5%和至少7%)的两种以上1类成分。本发明的香味喷发香精谐香剂出乎意料地改善了香精组合物的性能(例如,香味喷发速度和香味强度)。
本发明的范围内还涉及优选以按消费品重量计0.05至20重量%的水平包含一种或多种本发明的香精谐香剂的消费品。所述消费品的实例包括洗发剂、护发剂、染发剂、头发清新剂、头发固定或定型助剂、头发漂白剂、头发染料或着色剂、肥皂如条皂、沐浴液、化妆品制备物、通用清洁剂、浴厕清洁剂、地板清洁剂、窗户清洁剂、浴巾(bath tissue)、纸巾、一次性擦拭巾、尿布疹乳膏或护臀膏、婴儿爽身粉、尿不湿、围嘴、婴儿擦拭巾、口腔护理产品、牙膏、漱口水、牙齿增白剂、义齿粘附剂、洗手液、抗炎香油、抗炎软膏、抗炎喷雾剂、漂白剂、保健设备、牙线、牙刷、卫生棉塞、卫生巾、个人护理产品、防晒露、防晒喷雾剂、基于蜡的除臭剂、二醇型除臭剂、皂型除臭剂、面部乳液、身体乳液、手部乳液、爽身粉、剃须膏、浸浴用品、去角质磨砂膏、足霜、面巾、清洁擦拭巾、织物护理产品、织物柔顺剂、织物清新剂、熨烫水、液体衣物洗涤剂、粉末衣物洗涤剂、液体碗碟洗涤剂、自动碗碟洗涤剂、单位剂量片剂或胶囊、增味剂、干衣机片板(drier sheet)、精制香精(fine fragrance)、固体香料、粉末粉底、液体粉底、眼影、唇膏或润唇膏、淡香水产品(Eau De Toilette product)、除臭剂、地毯除臭剂、蜡烛、房间除臭剂、消毒剂、气溶胶止汗剂、棒式止汗剂(stickantiperspirant)、滚抹式止汗剂、乳液喷雾止汗剂、透明乳液棒式止汗剂、软固体止汗剂、乳液滚抹式止汗剂、透明乳液棒式止汗剂、不透明乳液棒式止汗剂、透明凝胶止汗剂、透明棒式除臭剂、喷雾除臭剂、香料凝胶(perfume gel)、香料乳液(perfume emulsion)、香料乳膏(perfume cream)、香料油(perfume oil)、蜡、头发香料(hair perfume)、布香料(clothperfume)、除臭剂香料(deodorant perfume)、起泡浴液(foaming bath)、沐浴油、沐浴盐、沐浴囊(bath sachet)、沐浴香料晶(bath crystal)、沐浴香料片(bath tablet)、香料宝石(perfume jewel)、香味聚合物(fragranced polymer)和用于数字装置的香精组合物。
本发明的一个或多个实施方案的细节在以下描述中说明。本发明的其他特征、目的和优点根据说明书和权利要求书将是明显的。
发明详述
当将清洁产品如粉末洗涤剂倒入水中时,开始起泡并且消费者在其蒸发时开始体验香味。常规的香味喷发分析并不关注这个阶段。
申请人已经发现,具有高实验速度(扩散速度的指示)的香精成分出乎意料地提高了香精谐香剂在起泡和香味喷发阶段的性能。因此,单独地测试香精成分它们的实验速度并且将其分成三类。
1类香精成分各自具有8.5cm/秒以上的实验速度。这些香精成分中的每一个都典型地具有:(i)选自由以下组成的组的至少八个原子:碳原子、氢原子、氧原子和氮原子;(ii)选自由以下组成的组的官能团:醛(-CHO)、羟基(-OH)、烯烃(C=C)、醚(-O-)、酯(-C(O)O-)、苯基、呋喃基和吡嗪基基团;(iii)室温下0.0003至20mmHg(例如0.003至7mmHg)的蒸汽压;(iv)范围在100至280原子质量单位内的分子量(例如100和200原子质量单位);以及(v)1至5.5的logP值(例如,1.5至4.5)。其他合适的官能团包括酮(R-CO-R)、芳族如芳族仲胺(Ar-NH-R)、羧酸(R-COOH)、内酯和环氧化物官能团。在特别的实施方案中,官能团是醛、芳族或酯官能团。参见Poling等人(2000)The Properties of Gases and Liquids(气体和液体的性质),第5版,McGraw-Hill。还参见US 6,143,707、US 6,601,789、US 2004/0138078和EP 0888440f或者涉及香精成分的一般物理性质的其他细节。
2类香精成分各自具有小于8.5cm/秒且大于5cm/秒的实验速度。3类香精成分各自具有5cm/秒以下的实验速度。
实验速度计算为香精行进的距离(60cm)除以扩散速度。术语“扩散速度”是指在室温(即25℃)温和搅拌2升水和10g的含有嗅觉有效量的香料成分(以0.005-0.1重量%配料)的模型粉末洗涤剂)的情况下,从混合的那一刻起在距离60cm处测量的香精成分嗅觉检测所需的时间。除了被测量的香精成分以外,模型粉末洗涤剂不含有任何其他香精。
实验速度提供了香精成分在起泡阶段如何表现的指示,并且产生了用于消费品(包括织物护理产品、个人护理产品和家庭护理产品)的香味喷发技术指导。实验速度测量了香精成分从水中蒸发并且行进至鼻子是有多快。香精成分的几种物理性质影响扩散速度,诸如蒸汽压,分子量,LogP等。
出乎意料地,在成分水平、谐香剂水平和总产品制剂水平上的性能与先前的成分性能研究或已知的心理-物理化学性质和它们之间的关系没有相关性。相反,香精成分的扩散速度在香味强度和空间填充能力方面直接影响消费品性能。
术语“空间填充能力”是指在25℃温和搅拌的情况下,从混合2升水与10g的含有嗅觉有效量的香精成分(按模型粉末洗涤剂的重量计以0.005至0.1%配料)的模型粉末洗涤剂那时起10分钟后的香味强度。
因此,本发明提供了用于消费品的高强度香味喷发香精谐香剂,其具有增强的扩散速度、香味强度和香味喷发/空间填充,增加的恶臭覆盖/减少,清新和清洁的香味感官属性,优异的卫生和增加的持续性。
如本领域惯用的,“香精谐香剂”是指两种以上香精原料或香精成分的混合物或掺合物。本领域已知各种各样的化学品作为香精成分,包括诸如醛、酮和酯的化合物。更常见的是,已知由各种化学组分的复杂混合物组成的天然存在的植物油和动物油以及渗出物用作香精成分。在这方面,本文中的香精成分在其组成方面可以是相对简单的,由单一化学品组成,或者可以包括天然和合成化学组分的高度复杂的复杂混合物,所有这些都选择用于提供任何所需气味。
在一些实施方案中,本发明的香精谐香剂由至少2种(例如,至少3种、至少4种、至少5种、至少6种和至少7种)1类香精成分构成。在其他实施方案中,香精谐香剂包括至少10种选自1类和2类香精成分的香精成分,例如,至少15种、至少20种、至少25种、至少30种、至少35种、至少40种、至少45种和/或至少50种1类和2类香精成分。构成香精谐香剂的香精原料越多,香精谐香剂就被认为越复杂。例如,更简单的香精谐香剂包括数量相对较少的香精原料,诸如少于10种、少于8种和/或少于5种香精原料。相比之下,更复杂的香精谐香剂包括数量相对较多的香精原料,例如,至少25种、至少30种和/或至少40种或更多种香精原料。
“净(neat)”或“净油(neat oil)”是指不含外来物质的香精谐香剂。净香精谐香剂仅包括香精成分,并且未囊封和/或未与将导致香精成分释放延迟的其他化合物结合。在某些实施方案中,香精谐香剂是“净香精谐香剂”。
香精谐香剂的“香味喷发”是指在使用中溶解产品时经历的香味强度和体积的积累。这可以是香料的瞬间“爆发”或扩散的长期香味喷发。根据本发明,可以通过实验速度、气味性能(例如,在开始起泡阶段后25秒的香味强度)和/或空间填充能力(例如,在开始起泡阶段后10分钟在封闭室中的香味强度)来评价“香味喷发”。具有“高强度香味喷发”的香精谐香剂具有8.5cm/秒以上的实验速度,至少2.5的气味性能和/或至少2.5的空间填充能力(感官等级从0到5,0表示没有气味而5表示非常强的气味)。
本发明的香精谐香剂典型地具有至少0.1(例如,至少0.5、至少1、0.1至5、0.2至4、0.5至3以及1.5)的香味喷发香味强度指数。香味喷发香味强度指数是(i)香精谐香剂或成分的感官强度评分与(ii)作为标准的戊基乙醇酸烯丙酯(AAG)的感官强度评分之间的比率。当AAG以0.015%的浓度溶解在适当的溶剂(例如邻苯二甲酸二乙酯)中时,通过感官小组评价AAG的感官强度评分等级(在0至100的范围内)。在浓度为0.015%的情况下,也由同一小组评价香精谐香剂或成分。评分为5意指香精或成分具有中等气味。评分为15表明香精或成分具有中等气味。评分为35表明强的气味。
如下评价香味喷发香味强度评分:在评价开始之前,将一条洗过的毛巾放置在小室中,以便给出足够的时间以饱和并达到容积中的平衡浓度。小组从用于空间填充的窗来评价强度。AAG被评价作为标准。然后将香味喷发香味强度指数计算为:香精谐香剂或成分的感官强度评分/AAG的感官强度评分。
1类和2类成分中的每一种具有至少0.1(例如,至少0.2、至少0.5、0.1至5、0.2至4和0.5至3)的香味喷发香味强度。
香精成分、标准、谐香剂、香精组合物和消费品各自可以如上所述进行评价,并且还可以按照本领域熟知的方案使用不同的等级进行评价,其可以标准化为0-100的等级用于计算香味强度指数。
每个1类成分典型地具有大于5000焦耳(例如,5001至50000焦耳和5500至25000焦耳)的动能。每个2类成分具有1400至5000焦耳的动能。
根据以下等式使用其质量和速度计算分子的动能(KE):KE=1/2X质量X速度2。速度是分子在理想气体中行进的速度,其分子占据可不计的空间并且不具有相互作用,因此完全地遵守气体定律。动力学理论假设所有处于气态的分子表现理想,这对于在空气中高度稀释的香精分子是合理的。不受任何理论束缚,当在消费品中使用时,具有高动能的香精分子可以容易地蒸发并且以高速行进到达鼻子。
香精成分的蒸汽压可以使用压力计容易地测量,或者根据参考程序EPI suitev4.00,2000-2008 U.S.Environmental Protection Agency)计算。1类香精成分在室温可以具有0.0002mmHg至20mmHg的蒸汽压,其中在室温(即,25℃),蒸汽压的下限可以是0.0002、0.0005、0.001或0.005mmHg,并且其量的上限可以是20、15、10、15、10、8和7mmHg。在文献中获得许多香精成分的蒸汽压数据。参见例如Yaws’Handbook of Thermodynamic andPhysical Properties of Chemical Compounds(Norwich,NY,2003)。
1类或2类香精成分的分子量可以变化,但是优选地在100至280道尔顿的范围内,其中分子量的下限可以是100、110、120、130、140、150、160、170、180或190道尔顿,并且分子量的上限可以是280、270、260、250、240、230、220、210或200道尔顿。在一些实施方案中,1类或2类香精成分各自的分子量在120至200道尔顿的范围内。
作为疏水性和水溶性的量度,材料的辛醇-水分配系数(P)(即材料在辛醇和水中的平衡浓度的比率)在文献中是众所周知的(参见Leo等人(1971)Chem.Rev.71:526-616;Hansch等人(1968)J.Org.Chem.33:347-350)。高分配系数值更方便地以它们对基数10的对数形式(logP)给出。虽然logP值可以通过实验测量(即直接测量),并且测量的logP数据可用于许多香料,但是最方便地使用数学算法计算或近似估算logP值。存在若干公认的计算或估算方法,其可商购获得和/或描述于文献中(参见例如Leo(1993)Chem.Rev.93(4):1281-1306)。通常这些模型高度相关,但是对于特定材料可能产生绝对项不同(高达0.5个对数单位或甚至更多)的logP值。已经报道了许多香精成分的logP值。例如,Pomona92数据库(可从Daylight Chemical Information Systems,Inc.(Irvine,CA)获得)含有许多,连同原始文献的引用。根据本发明的香精谐香剂,1类或2类香精成分的logP值为至少1.5个单位。更具体地,1类或2类香精成分的logP值为1.5至5.5个单位,其中下限可以是1.5、1.6、1.7、1.8、1.9或2,并且上限可以是5.5、5、4.8、4.6、4.5或4.4。在一些实施方案中,1类香精成分各自具有1.5至5.5、或者更优选1.7至4.4的logP值。
如本文中所述,基于其实验速度、扩散速度、气味性能和/或空间填充能力,发现香精谐香剂具有高冲击强度香味喷发。在一些实施方案中,本发明的香精谐香剂具有一种或多种(例如,至少四种、至少5种和至少6种)1类香精成分,其扩散速度为7秒以下,如通过在距离来源60cm处的嗅觉检测时间所确定的。另外,香精谐香剂可以具有一种或多种(例如,至少四种、至少5种和至少6种)2类香精成分,其扩散速度为大于7秒且小于12秒。因此,本发明的香精谐香剂具有0至12秒(例如,0至8秒、0至6秒和0至5秒)的扩散速度,其中下限可以是约0、0.5、1、1.5、2、2.5、3、3.5或4秒,并且上限可以是约12、11、10、9、8、7.5、7、6.5或6秒。
表1中提供了1类香精成分的非限制性实例及其各自特性。
表1
注:EV:实验速度;KE:动能;MW:分子量
表2中提供了2类香精成分的非限制性实例及其各自特性。
表2
表1和2中列出的香精成分可容易地从商业来源诸如IFF(New York,NY)、GivaudanFragrances Corp.(East Hanover,NJ)、Symrise(Branchburg,NJ)和Firmenich(Princeton,NJ)获得。
香精谐香剂的1类香精成分(即组分(i))的总量占按香精谐香剂重量计的至少7%(例如,至少8%、至少9%、至少10%、至少15%、至少20%、7至95%、7至75%和8至75%),其中下限可以是7、8、9、10、15、20、25、30或35重量%,并且上限可以是100、95、90、80、75、70、65、60、55、50、45或40重量%。
香精谐香剂的2类香精成分(即组分(ii))的总量占按香精谐香剂重量计的至少5%(例如,5至95%、5至90%、5至85%、5至80%和5至70%),其中下限可以是5、10、15、20、25、30或35重量%,并且上限可以是95、90、85、80、75、70、65、60、55、50、45或40重量%。
当组分(i)由多于一种1类香精成分组成时,每种1类香精成分可以以基于组分(i)的重量计0.02至99%(例如,0.02至90%、0.02至80%、0.02至70%、0.02至50%、0.02至40%、0.02至30%、0.02至20%和0.02至10%)的水平存在。在一些实施方案中,1类香精成分中的每一者占香精谐香剂重量计的小于40%(例如,小于20%、小于12%)、0.0001至10%和0.001至5%)。
同样地,当组分(ii)由多于一种2类香精成分组成时,每种2类香精成分可以以基于组分(ii)的重量计0.01至99%(例如,0.02至90%、0.02至80%、0.02至70%、0.02至50%、0.02至40%、0.02至30%、0.02至20%和0.02至10%)的水平存在。在一些实施方案中,2类香精成分中的每一者占香精谐香剂重量计的小于40%(例如,小于30%、小于20%、小于12%)、0.0001至10%和0.001至5%)。
除了组分(i)和(ii)以外,香精谐香剂还可以任选地包括0至80重量%的3类香精成分,其中下限可以是0、5、10、15、20、25、30、35、40、45或50重量%,并且上限可以是80、75、70、65、60或55重量%。
此外,香精谐香剂中可以以0至30重量%(例如,0至20重量%和0至15重量%)的量包含精油。本发明合适的精油的实例包括但不限于:动物香精,诸如麝香油、灵猫香(civet)、海狸香和龙涎香;和植物香精,诸如肉豆蔻提取物、白豆蔻(cardomon)提取物、姜提取物、肉桂提取物、广藿香油、天竺葵油、橙油、柑橘油、橙花提取物、柏木(cedarwood)、香根草、杂薰衣草(lavandin)、依兰提取物、晚香玉提取物、檀香油、香柠檬油、迷迭香油、留兰香油、薄荷油、柠檬油、薰衣草油、香茅油、洋甘菊油(德国、摩洛哥或罗马)、丁香油、鼠尾草油、橙花油、岩蔷薇油、桉树油、马鞭草油、含羞草提取物、水仙提取物、胡萝卜籽提取物、茉莉提取物、小茴香提取物、海索草提取物、杜松提取物、柠檬草提取物、乳香提取物、玫瑰提取物迷迭香提取物、玫瑰天竺葵提取物及其混合物。
香精谐香剂典型地含有:(i)10至75%的前调(top note)(例如,15至70%和20至65%),(ii)10至75%的中调(middle note)(例如,15至70%、20至65%和25至65%),和(iii)1至20基调(base note)(例如,1.5至15%和2至10%)。
本发明的香精谐香剂还可以以基于香精谐香剂总重量计0至93重量%的量包括一种或多种无气味溶剂或氧化抑制剂或其混合物,其中下限可以是0、5、10、15、20、25、30、35、40、45或50重量%,并且上限可以是93、90、85、80、75、70、65、60或55重量%。
用于制备香精谐香剂的成分(1类、2类和3类成分以及其他辅剂)的实例包括:
i)烃,如,例如,3-蒈烯、α-蒎烯、β-蒎烯、α-松油烯、γ-松油烯、p-伞花烃、甜没药烯、莰烯、石竹烯、柏木烯、法呢烯、柠檬烯、长叶烯、香叶烯、罗勒烯、朱栾倍半萜、(E,Z)-1,3,5-十一烷三烯、苯乙烯和二苯基甲烷;
ii)脂族醇,如,例如,己醇、辛醇、3-辛醇、2,6-二甲基-庚醇、2-甲基-2-庚醇、2-甲基-2-辛醇、(E)-2-己烯醇、(E)-和(Z)-3-己烯醇、1-辛烯-3-醇、3,4,5,6,6-五甲基-3/4-庚烯-2-醇和3,5,6,6-四甲基-4-亚甲基庚-2-醇的混合物、(E,Z)-2,6-壬二烯醇、3,7-二甲基-7-甲氧基辛-2-醇、9-癸烯醇、10-十一烯醇、4-甲基-3-癸烯-5-醇、脂族醛及其缩醛如例如己醛、庚醛、辛醛、壬醛、癸醛、十一醛、十二醛、十三醛、2-甲基辛醛、2-甲基壬醛、(E)-2-己烯醛、(Z)-4-庚烯醛、2,6-二甲基-5-庚烯醛、10-十一碳烯醛、(E)-4-癸烯醛、2-十二烯醛、2,6,10-三甲基-5,9-十一碳二烯醛、庚醛-二乙缩醛、1,1-二甲氧基-2,2,5-三甲基-4-己烯和香茅基氧基乙醛;
iii)脂族酮及其肟,如,例如,2-庚酮、2-辛酮、3-辛酮、2-壬酮、5-甲基-3-庚酮、5-甲基-3-庚酮肟、2,4,4,7-四-甲基-6-辛烯-3-酮、脂族含硫化合物如例如3-甲硫基-己醇、乙酸3-甲硫基己酯、3-巯基己醇、乙酸3-巯基己酯、丁酸3-巯基-己酯、乙酸3-乙酰基硫代己酯、1-薄荷烯-8-硫醇和脂族腈(例如,2-壬烯腈、2-十三碳烯腈、2,12-十三碳烯腈、3,7-二甲基-2,6-辛二烯腈和3,7-二甲基-6-辛烯腈);
iv)脂族羧酸及其酯,如,例如,(E)-和(Z)-3-己烯基甲酸酯、乙酰乙酸乙酯、乙酸异戊酯、乙酸己酯、乙酸3,5,5-三甲基己酯、乙酸3-甲基-2-丁烯酯、(E)-2-己烯基乙酸酯、(E)-和(Z)-3-己烯基乙酸酯、乙酸辛酯、乙酸3-辛酯、1-辛烯-3-基乙酸酯、丁酸乙酯、丁酸丁酯、丁酸异戊酯、丁酸己酯、(E)-和(Z)-3-己烯基异丁酸酯、巴豆酸己酯、异戊酸乙酯、戊酸乙基-2-甲酯、己酸乙酯、己酸烯丙酯、庚酸乙酯、庚酸烯丙酯、辛酸乙酯、乙基-(E,Z)-2,4-癸二烯酸酯、甲基-2-辛炔酸酯、甲基-2-壬炔酸酯、氧乙酸烯丙基-2-异戊酯和甲基-3,7-二甲基-2,6-辛二烯酸酯;
v)非环萜烯醇,如,例如,香茅醇、香叶醇、橙花醇、芳樟醇、熏衣草醇、橙花叔醇、法呢醇、四氢芳樟醇、四氢香叶醇、2,6-二甲基-7-辛烯-2-醇、2,6-二甲基辛-2-醇、2-甲基-6-亚甲基-7-辛烯-2-醇、2,6-二甲基-5,7-辛二烯-2-醇、2,6-二甲基-3,5-辛二烯-2-醇、3,7-二甲基-4,6-辛二烯-3-醇、3,7-二甲基-1,5,7-辛三烯-3-醇、2,6-二甲基-2,5,7-辛三烯-1-醇以及它们的甲酸酯、乙酸酯、丙酸酯、异丁酸酯、丁酸酯、异戊酸酯、戊酸酯、己酸酯、巴豆酸酯、顺芷酸酯和3-甲基-2-丁烯酸酯;
vi)非环萜烯醛和酮,如,例如,香叶醛、橙花醛、香茅醛、7-羟基-3,7-二甲基辛醛、7-甲氧基-3,7-二甲基辛醛、2,6,10-三甲基-9-十一碳烯醛、α-甜橙醛、β-甜橙醛、香叶基丙酮以及香叶醛、橙花醛和7-羟基-3,7-二甲基辛醛的二甲基-和二乙基缩醛;
vii)环萜烯醇,如,例如,薄荷醇、异胡薄荷醇、α-松油醇、松油烯-4-醇、薄荷烷-8-醇、薄荷烷-1-醇、薄荷烷-7-醇、冰片、异冰片、氧化芳樟醇、诺卜醇、柏木醇、龙涎醇、岩兰烯醇、愈创醇以及α-松油醇、松油烯-4-醇、甲-8-醇、甲-1-醇、甲-7-醇、冰片、异冰片、氧化芳樟醇、诺卜醇、柏木醇、龙涎醇、岩兰烯醇和愈创醇的甲酸酯、乙酸酯、丙酸酯、异丁酸酯、丁酸酯、异戊酸酯、戊酸酯、己酸酯、巴豆酸酯、顺芷酸酯和3-甲基-2-丁烯酸酯;
viii)环萜烯醛和酮,如,例如,薄荷酮、异薄荷酮、8-巯基薄荷烷-3-酮、香芹酮、樟脑、小茴香酮、α-紫罗酮、β-紫罗酮、α-n-甲基紫罗酮、β-n-甲基紫罗酮、α-异甲基紫罗酮、β-异甲基紫罗酮、α-鸢尾酮、α-大马酮、β-大马酮、β-大马烯酮、δ-大马酮、γ-大马酮、1-(2,4,4-三甲基-2-环己烯-1-基)-2-丁烯-1-酮、1,3,4,6,7,8a-六氢-1,1,5,5-四甲基-2H-2,4a-亚甲基萘-8(5H-)-酮、诺卡酮、二氢诺卡酮;乙酰化柏木油(甲基柏木酮);
ix)环醇,如,例如,4-叔丁基环己醇、3,3,5-三甲基环己醇、3-异龙脑基环己醇、2,6,9-三甲基-Z2,Z5,E9-环十二烷三烯-1-醇、2-异丁基-4-甲基四氢-2H-吡喃-4-醇;
x)环脂族醇,如,例如,α,3,3-三甲基环-己基甲醇、2-甲基-4-(2,2,3-三甲基-3-环戊-1-基)丁醇、2-甲基-4-(2,2,3-三甲基-3-环戊-1-基)-2-丁烯-1-醇、2-乙基-4-(2,2,3-三甲基-3-环戊-1-基)-2-丁烯-1-醇、3-甲基-5-(2,2,3-三甲基-3-环戊-1-基)-戊-2-醇、3-甲基-5-(2,2,3-三甲基-3-环戊-1-基)-4-戊烯-2-醇、3,3-二甲基-5-(2,2,3-三甲基-3-环戊-1-基)-4-戊烯-2-醇、1-(2,2,6-三甲基环己基)戊-3-醇、1-(2,2,6-三甲基环己基)己-3-醇;
xi)环醚和环脂族醚,如,例如,桉树脑、甲基柏木醚、环十二烷基甲基醚;
xii)(乙氧基甲氧基)环十二烷;α-柏木烯环氧化物、3a,6,6,9a-四甲基-十二氢萘并[2,1-b]呋喃、3a-乙基-6,6,9a-三甲基十二氢萘并[2,1-b]呋喃、1,5,9-三甲基-13-氧杂二环[10.1.0]-十三碳-4,8-二烯、玫瑰醚、2-(2,4-二甲基-3-环己烯-1-基)-5-甲基-5-(1-甲基丙基)-1,3-二烷-;
xiii)环酮,如,例如,4-叔丁基环己酮、2,2,5-三甲基-5-戊基环戊酮、2-庚基环戊酮、2-戊基环戊酮、2-羟基-3-甲基-2-环戊烯-1-酮、3-甲基-顺-2-戊烯-1-基-2-环戊烯-1-酮、3-甲基-2-戊基-2-环戊烯-1-酮、3-甲基-4-环十五烯酮、3-甲基-5-环十五烯酮、3-甲基环十五烷酮、4-(1-乙氧基乙烯基)-3,3,5,5-四甲基环己酮、4-叔戊基环己酮、5-环十六烯-1-酮、6,7-二氢-1,1,2,3,3-五甲基-4(5H)-茚酮、5-环十六烯-1-酮、8-环十六烯-1-酮、9-环十七烯-1-酮、环十五烷酮、环脂族醛如例如2,4-二甲基-3-环己烯甲醛、2-甲基-4-(2,2,6-三甲基-环己烯-1-基)-2-丁烯醛、4-(4-羟基-4-甲基戊基)-3-环己烯甲醛、4-(4-甲基-3-戊烯-1-基)-3-环己烯甲醛;
xiv)环脂族酮,如,例如,1-(3,3-二甲基环己基)-4-戊烯-1-酮、1-(5,5-二甲基-1-环己烯-1-基)-4-戊烯-1-酮、2,3,8,8-四甲基-1,2,3,4,5,6,7,8-八氢-2-萘基甲基-酮、甲基-2,6,10-三甲基-2,5,9-环十二碳三烯酮、叔丁基-(2,4-二甲基-3-环己烯-1-基)酮;
xv)环醇的酯,如,例如,乙酸2-叔丁基环己酯、乙酸4-叔丁基环己酯、乙酸2-叔戊基环己酯、乙酸4-叔戊基环己酯、乙酸十氢-2-萘基酯、3-戊基四氢-2H-吡喃-4-基乙酸酯、十氢-2,5,5,8a-四甲基-2-萘基乙酸酯、4,7-亚甲基-3a,4,5,6,7,7a-六氢-5或6-茚基乙酸酯、4,7-亚甲基-3a,4,5,6,7,7a-六氢-5或6-茚基丙酸酯、4,7-亚甲基-3a,4,5,6,7,7a-六氢-5或6-茚基-异丁酸酯、4,7-亚甲基八氢-5或6-茚基乙酸酯;
xvi)环脂族羧酸的酯,如,例如,3-环己基-丙酸烯丙酯、环己基氧乙酸烯丙酯、二氢茉莉酸甲酯、茉莉酸甲酯、2-己基-3-氧代环戊烷甲酸甲酯、2-乙基-6,6-二甲基-2-环己烯甲酸乙酯、2,3,6,6-四甲基-2-环己烯甲酸乙酯、2-甲基-1,3-二氧戊环-2-乙酸乙酯;
xvii)芳族和脂族醇,如,例如,苄醇、1-苯基乙醇、2-苯基乙醇、3-苯基丙醇、2-苯基丙醇、2-苯氧基乙醇、2,2-二甲基-3-苯基丙醇、2,2-二甲基-3-(3-甲基苯基)丙醇、1,1-二甲基-2-苯基乙醇、1,1-二甲基-3-苯基丙醇、1-乙基-1-甲基-3-苯基丙醇、2-甲基-5-苯基戊醇、3-甲基-5-苯基戊醇、3-苯基-2-丙烯-1-醇、4-甲氧基苄醇、1-(4-异丙基苯基)乙醇;
xviii)脂族醇和脂族羧酸的酯,如,例如,乙酸苄酯、丙酸苄酯、异丁酸苄酯、异戊酸苄酯、乙酸2-苯基乙酯、丙酸2-苯基乙酯、异丁酸2-苯基乙酯、异戊酸2-苯基乙酯、乙酸1-苯基乙酯、乙酸α-三氯甲基苄酯、乙酸α,α-二甲基苯基乙酯、丁酸α,α-二甲基苯基乙酯、乙酸肉桂酯、异丁酸2-苯氧基乙酯、乙酸4-甲氧基苄酯、芳脂族醚如例如2-苯基乙基甲基醚、2-苯基乙基异戊基醚、2-苯基乙基-1-乙氧基乙基醚、苯基乙醛二甲基缩醛、苯基乙醛二乙基缩醛、氢化阿托醛二甲基缩醛、苯基乙醛甘油缩醛、2,4,6-三甲基-4-苯基-1,3-二烷、4,4a,5,9b-四氢茚并[1,2-d]-m-二英、4,4a,5,9b-四氢-2,4-二甲基茚并[1,2-d]-m-二英;
xix)芳族和脂族醛,如,例如,苯甲醛;苯乙醛、3-苯基丙醛、氢化阿托醛、4-甲基苯甲醛、4-甲基苯乙醛、3-(4-乙基苯基)-2,2-二甲基丙醛、2-甲基-3-(4-异丙基苯基)丙醛、2-甲基-3-(4-叔丁基苯基)丙醛、3-(4-叔丁基苯基)丙醛、肉桂醛、α-丁基肉桂醛、α-戊基肉桂醛、α-己基肉桂醛、3-甲基-5-苯基戊醛、4-甲氧基苯甲醛、4-羟基-3-甲氧基苯甲醛、4-羟基-3-乙氧基苯甲醛、3,4-亚甲基-二氧基苯甲醛、3,4-二甲氧基苯甲醛、2-甲基-3-(4-甲氧基苯基)丙醛、2-甲基-3-(4-亚甲基二氧基苯基)丙醛;
xx)芳族和脂族酮,如,例如,苯乙酮、4-甲基苯乙酮、4-甲氧基苯乙酮、4-叔丁基-2,6-二甲基苯乙酮、4-苯基-2-丁酮、4-(4-羟基苯基)-2-丁酮、1-(2-萘基)乙酮、二苯甲酮、1,1,2,3,3,6-六甲基-5-茚满基甲基酮、6-叔丁基-1,1-二甲基-4-茚满基甲基酮、1-[2,3-二氢-1,1,2,6-四甲基-3-(1-甲基-乙基)-1H-5-茚基]乙酮、5',6',7',8'-四氢-3',5',5',6',8',8'-六甲基-2-萘乙酮;
xxi)芳族和芳脂族羧酸及其酯,如,例如,苯甲酸、苯乙酸、苯甲酸甲酯、苯甲酸乙酯、苯甲酸己酯、苯甲酸苄酯、苯乙酸甲酯、苯乙酸乙酯、苯乙酸香叶酯、苯乙酸苯乙酯、肉桂酸甲酯、肉桂酸乙酯、肉桂酸苄酯、肉桂酸苯乙酯、肉桂酸肉桂酯、苯氧乙酸烯丙酯、水杨酸甲酯、水杨酸异戊酯、水杨酸己酯、水杨酸环己酯、水杨酸顺-3-己烯酯、水杨酸苄酯、水杨酸苯乙酯、2,4-二羟基-3,6-二甲基苯甲酸甲酯、3-苯基甘油酸乙酯、3-甲基-3-苯基甘油酸乙酯;
xxii)含氮芳族化合物,如,例如,2,4,6-三硝基-1,3-二甲基-5-叔丁基苯、3,5-二硝基-2,6-二甲基-4-叔丁基苯乙酮、肉桂腈、5-苯基-3-甲基-2-戊烯腈、5-苯基-3-甲基戊腈、邻氨基苯甲酸甲酯、甲基-N-甲基邻氨基苯甲酸酯、邻氨基苯甲酸甲酯与7-羟基-3,7-二甲基-辛醛的席夫碱、2-甲基-3-(4-叔丁基苯基)丙醛、或2,4-二甲基-3-环己烯甲醛、6-异丙基喹啉、6-异丁基喹啉、6-仲丁基喹啉、吲哚、粪臭素、2-甲氧基-3-异丙基吡嗪、2-异丁基-3-甲氧基吡嗪;
xxiii)苯酚、苯基醚和苯基酯,如,例如,草蒿脑、茴香脑、丁子香酚、丁子香酚甲基醚、异丁子香酚、异丁子香酚甲基醚、百里酚、香芹酚、二苯醚、β-萘基甲基醚、β-萘基乙基醚、β-萘基异丁基醚、1,4-二甲氧基苯、乙酸丁子香酚酯、2-甲氧基-4-甲基苯酚、2-乙氧基-5-(1-丙烯基)苯酚、苯乙酸对甲酚酯;
xxiv)杂环化合物,如,例如,2,5-二甲基-4-羟基-2H-呋喃-3-酮、2-乙基-4-羟基-5-甲基-2H-呋喃-3-酮、3-羟基-2-甲基-4H-吡喃-4-酮、2-乙基-3-羟基-4H-吡喃-4-酮;
xxv)内酯,如,例如,1,4-辛内酯、3-甲基-1,4-辛内酯、1,4-壬内酯、1,4-癸内酯、8-癸烯-1,4-内酯、1,4-十一内酯、1,4-十二内酯、1,5-癸内酯、1,5-十二内酯、1,15-十五内酯、顺式-和反式-11-十五碳烯-1,15-内酯、顺式-和反式-12-十五碳烯-1,15-内酯、1,16-十六内酯、9-十六烯-1,16-内酯、10-氧杂-1,16-十六内酯、11-氧杂-1,16-十六内酯、12-氧杂-1,16-十六内酯、亚乙基-1,12-十二烷二酸酯、亚乙基-1,13-十三烷二酸酯、香豆素、2,3-二氢香豆素和八氢香豆素;
xxvi)精油、凝结物(concrete)、净油(absolute)、树脂、树脂状物(resinoid)、香脂、酊剂,如例如,龙涎香酊、香树油、当归籽油、当归根油、大茴香油、缬草油、罗勒油、树苔净油、月桂油、艾蒿油、安息香树脂状物、香柠檬油、蜂蜡净油、桦木焦油、苦杏仁油、香旱芹油、布枯叶油、巴西檀木油、杜松油、菖蒲油、樟脑油、卡南迦油、小豆蔻油、卡藜油、肉桂油、金合欢净油、海狸香净油、香柏叶油、柏木油、岩蔷薇油、香茅油、柠檬油、苦配巴香脂、苦配巴香脂油、芫荽油、广木香根油、茴香油、柏树油、印蒿油、莳萝草油、莳萝子油、苦橙(eau debrouts)净油、橡苔净油、榄香油、龙蒿油、柠檬桉油、桉树油(桉树脑型)、小茴香油、冷杉针油、白松香油、白松香树脂、天竺葵油、葡萄柚油、愈创木油、古芸香脂、古芸香脂油、蜡菊净油、蜡菊油、姜油、鸢尾根净油、鸢尾根油、茉莉净油、菖蒲油、蓝甘菊油、罗马甘菊油、胡萝卜籽油、卡藜油、松针油、留兰香油、页蒿油、岩蔷薇油、岩蔷薇净油、岩蔷薇树脂、杂薰衣草净油、杂薰衣草油、薰衣草净油、薰衣草油、柠檬草油、圆叶当归油、蒸馏酸橙油、压榨酸橙油、沉香油、山苍子油、月桂叶油、肉豆蔻油、马郁兰油、橘子油、香厚壳桂(皮)油、含羞草净油、黄葵籽油、麝香酊、鼠尾草油、肉豆蔻油、没药净油、没药油、桃金娘油、丁香叶油、丁香花蕾油、橙花油、乳香净油、乳香油、红没药(opopanax)油、橙花净油、橙油、牛至油、玫瑰草油、广藿香油、紫苏油、秘鲁香脂油、欧芹叶油、欧芹籽油、橙叶油、薄荷油、胡椒油、甘椒油、松油、胡薄荷油、玫瑰净油、玫瑰木油、玫瑰油、迷迭香油、达尔马提亚鼠尾草油、西班牙鼠尾草油、檀木油、芹菜籽油:穗薰衣草油、八角茴香油、苏合油、万寿菊油、冷杉针油、茶树油、松脂油、百里香油、妥卢香脂、零陵香豆净油、晚香玉净油、香草提取物、紫罗兰叶净油、马鞭草油、香根草油、杜松子油、酒糟油、苦艾油、冬青油、依兰油、海索草油、灵猫净油、肉桂叶油、肉桂皮油、及其馏分或由其分离的成分;
(xxvii)香料,包括但不限于乙醛、二甲基硫醚、乙酸乙酯、丙酸乙酯、丁酸甲酯和丁酸乙酯。含有挥发醛或酯的香料包括例如乙酸肉桂酯、肉桂醛、柠檬醛、乙醛缩二乙醇、乙酸二氢香芹酯、甲酸丁子香酚酯和对甲基苯甲醚。在当前的香料油中可以存在的挥发性化合物的另外的实例包括:乙醛(苹果);苯甲醛(樱桃、杏仁);肉桂醛(肉桂醛);柠檬醛,即α柠檬醛(柠檬、酸橙);橙花醛,即β柠檬醛(柠檬、酸橙);癸醛(橙、柠檬);乙基香草醛(香草、奶油);天芥菜精,即胡椒醛(香草、奶油);香草醛(香草、奶油);α-戊基肉桂醛(香的果味香料);丁醛(黄油、奶酪);戊醛(黄油、奶酪);香茅醛(改性剂,许多类型);癸醛(柑橘类水果);醛C-8(柑橘类水果);醛C-9(柑橘类水果);醛C-12(柑橘类水果);2-乙基丁醛(浆果);己烯醛,即反式-2(浆果);甲苯醛(樱桃、杏仁);藜芦醛(香草);2,6-二甲基-5-庚烯醛,即甜瓜醛(甜瓜);2-6-二甲基辛醛(绿色水果);和2-十二烯醛(柑橘、橘子);樱桃;或葡萄,及其混合物。组合物还可以包含调味剂和人工甜味剂。如本文中使用的,香料理解为包括来源于多香果、罗勒、辣椒、肉桂、丁香、小茴香、莳萝、大蒜、马郁兰、肉豆蔻、红辣椒、黑胡椒、迷迭香和姜黄的香辛料油树脂;精油,大茴香油、页蒿油、丁香油、桉树油、小茴香油、大蒜油、姜油、薄荷油、洋葱油、胡椒油、迷迭香油、留兰香油、柑橘油、橙油、柠檬油、苦橙油、红柑油(tangerine oil);葱味香精,大蒜、韭葱、细香葱和洋葱;植物提取物,山金车花提取物、洋甘菊花提取物、啤酒花提取物、金盏花提取物;植物香料提取物,黑莓、菊苣根、可可、咖啡、可乐树、甘草根、玫瑰果、菝葜根、美洲檫木树皮;罗望子和香草提取物,蛋白质水解产物,水解的植物蛋白,肉蛋白水解物,奶蛋白水解产物,和天然和人工的复合香料,包括在S.Heath,Source Book of Flavors,Avi Publishing Co.,Westport Connecticut,1981,第149-277页中公开的那些。具体的优选香料辅料包括但不限于以下:大茴香油;丁酸乙基-2-甲酯;香草醛;顺式-3-庚烯醇;顺式-3-己烯醇;反式-2-庚烯醛;戊酸丁酯;2,3-二乙基吡嗪;甲基环戊烯醇酮;苯甲醛;缬草油;3,4-二甲氧基苯酚;乙酸戊酯;肉桂酸戊酯、y-丁内酯糠醛;三甲基吡嗪;苯乙酸;异戊醛;乙基麦芽酚;乙基香草醛;戊酸乙酯;丁酸乙酯;可可提取物;咖啡提取物;薄荷油;留兰香油;丁香油;茴香脑;小豆蔻油;冬青油;肉桂醛;戊酸乙基-2-甲酯;g-己烯内酯;2,4-癸二烯醛;2,4-庚二烯醛;甲基噻唑醇(4-甲基-5-b-羟基乙基噻唑);2-甲基丁硫醇;4-巯基-2-丁酮;3-巯基-2-戊酮;1-巯基-2-丙烷;苯甲醛;糠醛;糠醇;2-巯基丙酸;烷基吡嗪;甲基吡嗪;2-乙基-3-甲基吡嗪;四甲基吡嗪;多硫化物;二丙基二硫醚;甲基苄基二硫醚;烷基噻吩;2,3-二甲基噻吩;5-甲基糠醛;乙酰基呋喃;2,4-癸二烯醛;愈创木酚;苯基乙醛;b-癸内酯;d-柠檬烯;乙偶姻;乙酸戊酯;麦芽酚;丁酸乙酯;乙酰丙酸;胡椒醛;乙酸乙酯;正辛醛;正戊醛;正己醛;丁二酮;谷氨酸一钠;谷氨酸一钾;含硫氨基酸,例如半胱氨酸;水解的植物蛋白;2-甲基呋喃-3-硫醇;2-甲基二氢呋喃-3-硫醇;2,5-二甲基呋喃-3-硫醇;水解的鱼蛋白;四甲基吡嗪;丙基丙烯基二硫醚;丙基丙烯基三硫醚;二烯丙基二硫醚;二烯丙基三硫醚;二丙烯基二硫醚;二丙烯基三硫醚;4-甲基-2-[(甲硫基)-乙基]-1,3-二硫杂环戊烷;4,5-二甲基-2-(甲硫基甲基)-1,3-二硫杂环戊烷;4-甲基-2-(甲硫基甲基)-1,3-二硫杂环戊烷,以及美国专利号6,110,520和6,333,180中描述的香料成分;
(xxviii)恶臭中和剂,包括α,β-不饱和羰基化合物,包括但不限于US 6,610,648和EP 2,524,704中公开的那些,戊基肉桂醛,二苯甲酮,苯甲酸苄酯,苄基异丁子香酚,苯乙酸苄酯,水杨酸苄酯,肉桂酸丁酯,丁酸肉桂酯,异戊酸肉桂酯,丙酸肉桂酯,乙酸癸酯,肉豆蔻酸乙酯,肉桂酸异丁酯,水杨酸异戊酯,苯甲酸苯乙酯,苯乙酸苯乙酯,柠檬酸三乙酯,三丙二醇正丁醚,二环[2.2.1]庚-5-烯-2-羧酸的异构体,乙酯,纳米银,十一碳烯酸锌,β-萘基甲基醚,β-萘基酮,苄基丙酮。它们可以包括六氢-4,7-亚甲基茚-5-基丙酸酯和六氢-4,7-亚甲基茚-6-基丙酸酯的混合物;4-(2,6,6-三甲基-2-环己烯-1-基)-3-甲基-3-丁烯-2-酮;3,7-二甲基-2,6-壬二烯-1-腈;十二氢-3a,6,6,9a-四甲基萘并(2,1-b)呋喃;正十二烷二酸的乙二醇环酯;1-环十六碳烯-6-酮;1-环十七碳烯-10-酮;和玉米薄荷油。它们还可以包括1-环己基乙-1-基丁酸酯;1-环己基乙-1-基乙酸酯;1-环己基乙-1-醇;1-(4’-甲基乙基)环己基乙-1-基丙酸酯;和2’-羟基-1’-乙基(2-苯氧基)乙酸酯,其中每种化合物由国际香料和香精公司(International Flavors&Fragrances Inc)以商标VEILEX销售。更合适的恶臭中和剂是含有α-酮、苯甲醛或α,β-不饱和羰基部分的聚合物,诸如在美国申请公开2012/0294821、2013/0101544和2013/0101545中描述的那些;
(xxix)维生素,包括任何维生素、其衍生物及其盐。实例如下:维生素A及其类似物和衍生物(例如,视黄醇、视黄醛、棕榈酸视黄酯、视黄酸、维甲酸(tretinoin)和异维甲酸,其统称为类视色素(retinoids))、维生素E(生育酚及其衍生物)、维生素C(L-抗坏血酸及其酯和其他衍生物)、维生素B3(烟酰胺及其衍生物)、α羟基酸(诸如羟基乙酸、乳酸、酒石酸、苹果酸、柠檬酸等)和β羟基酸(诸如水杨酸等)。
(xxx)抗菌剂,包括氯苯呱哌嗪(bisguanidine)(例如,二葡萄糖酸氯己定)、二苯基化合物、苯甲醇、三卤代二苯脲、季铵化合物、乙氧基化苯酚以及苯酚化合物,诸如卤素取代的苯酚化合物,如PCMX(即,对氯-间二甲苯酚)、三氯生(即,2,4,4’-三氯-2’羟基-二苯醚)、百里酚和三氯卡班。
(xxxi)抗氧化剂,诸如β-胡罗卜素、维生素C(抗坏血酸)或其酯、维生素A或其酯、维生素E或其酯、叶黄素或其酯、木酚素、番茄红素、硒、类黄酮(flavonoid)、维生素状抗氧化剂如辅酶Q10(CoQ10)和谷胱甘肽、以及抗氧化酶如超氧化物歧化酶(SOD)、过氧化氢酶和谷胱甘肽过氧化物酶;
(xxxii)抗炎剂,包括例如水杨酸甲酯、阿司匹林(aspirin)、布洛芬(ibuprofen)和萘普生(naproxen)。可用于局部施用的另外的抗炎剂包括皮质类固醇,诸如但不限于,氟氢缩松(flurandrenolide)、丙酸氯倍他索(clobetasol propionate)、丙酸卤倍他索(halobetasol propionate)、丙酸氟替卡松(fluticasone propionate)、二丙酸倍他米松(betamethasone dipropionate)、苯甲酸倍他米松(betamethasone benzoate)、戊酸倍他米松(betamethasone valerate)、去羟米松(desoximethasone)、地塞米松(dexamethasone)、二醋酸二氟拉松(diflorasone diacetate)、糠酸莫米松(mometasonefuroate)、安西奈德(amcinodine)、哈西奈德(halcinonide)、氟轻松(fluocinolone)、醋酸氟轻松(fluocinonide acetonide)、地奈德(desonide)、曲安奈德(triamcinoloneacetonide)、氢化可的松(hydrocortisone)、醋酸氢化可的松(hydrocortisone acetate)、氟甲松龙(fluoromethalone)、甲泼尼龙(methylprednisolone)和氢化波尼松(predinicarbate);
(xxxiii)可以局部递送的麻醉剂,包括苯佐卡因(benzocaine)、氨苯丁酯(butamben)、苦味酸氨苯丁酯(butamben picrate)、可卡因(cocaine)、普鲁卡因(procaine)、丁卡因(tetracaine)、利多卡因(lidocaine)和盐酸普莫卡因(pramoxinehydrochloride);
(xxxiv)止痛剂,诸如布洛芬(ibuprofen)、双氯芬酸(diclofenac)、辣椒素(capsaicin)和利多卡因(lidocaine);
(xxxv)抗真菌剂。非限制性实例是咪康唑(micanazole)、克霉唑(clotrimazole)、布康唑(butoconazole)、芬替康唑(fenticonasole)、噻康唑(tioconazole)、特康唑(terconazole)、硫康唑(sulconazole)、氟康唑(fluconazole)、卤普罗近(haloprogin)、ketonazole、酮康唑(ketoconazole)、康唑(oxinazole)、益康唑(econazole)、伊曲康唑(itraconazole)、特比萘芬(torbinafine)、制霉菌素(nystatin)和灰黄霉素(griseofulvin);
(xxxvi)抗生素,诸如红霉素(erythromycin)、克林霉素(clindamycin)、合霉素(synthomycin)、四环素(tetracycline)、甲硝唑(metronidazole)等;
(xxxvii)抗病毒剂,包括泛昔洛韦(famcyclovir)、伐昔洛韦(valacyclovir)和阿昔洛韦(acyclovir)。
(xxxviii)抗寄生虫剂,诸如抗疥螨剂(scabicedes),如氯菊酯(permethrin)、克罗米通(crotamiton)、林丹(lindane)和伊维菌素(ivermectin);
(xil)抗感染剂和祛痘剂,包括过氧苯甲酰、硫磺、间苯二酚和水杨酸;
(xl)可用于局部施用的皮肤活性成分,包括例如霍霍巴油和芳香油,诸如水杨酸甲酯、冬青油、薄荷油、月桂油、桉树油和柑桔油,以及苯酚磺酸铵、碱式没食子酸铋、苯酚磺酸锌和水杨酸锌;
(xli)可用于局部施用的酶和辅酶,包括辅酶Q10、木瓜蛋白酶、脂酶、蛋白酶、超氧化物歧化酶、纤溶酶、脱氧核糖核酸酶、胰蛋白酶、胶原酶和舒替兰酶(sutilain);
(xlii)皮肤增白剂,诸如氢醌和莫诺苯宗(monobenzone);
(xliii)抗组胺剂,包括氯苯那敏(chlorpheniramine)、溴苯那敏(brompheniramine)、右氯苯那敏(dexchlorpheniramine)、曲普利啶(tripolidine)、氯马斯汀(clemastine)、苯海拉明(diphenhydramine)、异丙嗪(prometazine)、哌嗪、哌啶、阿司咪唑(astemizole)、氯雷他定(loratadine)和特非那定(terfonadine);
(xliv)化疗剂,诸如5-氟尿嘧啶(5-fluorouracil)、马索罗酚(masoprocol)、氮芥(mechlorethamine)、环磷酰胺(cyclophosphamide)、长春新碱(vincristine)、苯丁酸氮芥(chlorambucil)、链佐星(streptozocin)、甲氨蝶呤(methotrexate)、博来霉素(bleomycin)、更生霉素(dactinomycin)、柔红霉素(daunorubicin)、coxorubicin和他莫昔芬(tamoxifen);和
(xlv)驱昆虫剂,包括用于治疗虱子的杀虱剂,诸如除虫菊酯(pyrethrin)、氯菊酯、马拉硫磷(malathion)、林丹等。
除了以上列出的活性材料之外,本发明的产品还可以含有,例如以下染料、着色剂或颜料:乳黄素(lactoflavin)(核黄素(riboflavin))、β-胡萝卜素、核黄素-5’-磷酸酯、α-胡萝卜素、γ-胡萝卜素、角黄素(cantaxanthin)、赤藓红、姜黄素、喹啉黄、黄橙S、酒石黄、胭脂树素、降胭脂树素(胭脂树红、胭脂树橙(orlean))、辣椒红、辣椒红素、番茄红素、β-阿朴-8’-胡萝卜醛、β-阿朴-8’-胡萝卜素酸乙酯、叶黄素(xantophylls)(黄黄质、黄体素、隐黄质、玉红黄质、紫黄质、紫衫紫素(rodoxanthin))、坚牢洋红(fast carmine)(胭脂红酸、胭脂虫红)、偶氮玉红、胭脂虫红A(Ponceau 4R)、甜菜红、甜菜苷、花青素、苋菜红、专利蓝V、靛蓝I(靛蓝-胭脂红)、叶绿素、叶绿素的铜化合物、酸性亮绿BS(丽丝胺绿)、亮黑BN、植物碳、二氧化钛、铁氧化物和氢氧化物、碳酸钙、铝、银、金、颜料宝红BK(立索尔(lithol)宝红BK)、甲基紫B、维多利亚蓝R、维多利亚蓝B、阿西仑(acilan)亮蓝FFR(亮羊毛蓝FFR)、萘酚绿B、阿西仑坚牢绿10G(碱性坚牢绿10G)、ceres黄GRN、苏丹蓝II、群青、酞菁蓝、酞菁绿、坚牢酸性紫R。另外的天然获得的提取物(例如辣椒粉提取物、黑胡萝卜提取物、红球甘蓝提取物)可以用于着色目的。还利用以下命名的所谓铝色淀实现好的结果:FD&C黄5色淀、FD&C蓝2色淀、FD&C蓝1色淀、酒石黄色淀、喹啉黄色淀、FD&C黄6色淀、FD&C红40色淀、日落黄色淀、蓝光酸性红色淀、苋菜红色淀、Ponceau 4R色淀、赤藓红色淀、红2G色淀、诱惑红色淀(Allura Red Lake)、专利蓝V色淀、靛蓝胭脂红色淀、亮蓝色淀、棕HT色淀、黑PN色淀、绿S色淀及其混合物。
另外的香精成分描述于例如Arctander(2000)Perfume Flavors and Chemicals.卷I和II,Montclair,NJ;The Merck Index,第8版(1968)Merck&Co.,Inc.Rahway,NJ;Allured’s Flavor and Fragrance Materials(2015)Allured Publishing Corp.中。
香精谐香剂还可以以0.05至5重量%(0.05至2重量%、0.1至0.5重量%)的水平含有一种或多种抗菌剂。抗菌剂的实例包括,包括甲基甲酚、芳樟醇、松木超级精华(pinesuper extreme)、氯苯呱哌嗪(bisguanidine)(例如,二葡萄糖酸氯己定)、二苯基化合物、苯甲醇、三卤代二苯脲、季铵化合物、乙氧基化苯酚以及苯酚化合物,诸如卤素取代的苯酚化合物,如PCMX(即,对氯-间二甲苯酚)、三氯生(即,2,4,4’-三氯-2’羟基-二苯醚)、百里酚和三氯卡班。
香精谐香剂也可以含有0.05至20重量%(0.1至15重量%、0.2至10重量%和0.3至5重量%)的一种或多种恶臭中和剂,包括α,β-不饱和羰基化合物,包括但不限于US 6,610,648和EP 2,524,704中公开的那些,戊基肉桂醛,二苯甲酮,苯甲酸苄酯,苄基异丁子香酚,苯乙酸苄酯,水杨酸苄酯,肉桂酸丁酯,丁酸肉桂酯,异戊酸肉桂酯,丙酸肉桂酯,乙酸癸酯,肉豆蔻酸乙酯,肉桂酸异丁酯,水杨酸异戊酯,苯甲酸苯乙酯,苯乙酸苯乙酯,柠檬酸三乙酯,三丙二醇正丁醚,二环[2.2.1]庚-5-烯-2-羧酸的异构体,乙酯,纳米银,十一碳烯酸锌,β-萘基甲基醚,β-萘基酮,苄基丙酮。它们可以包括六氢-4,7-亚甲基茚-5-基丙酸酯和六氢-4,7-亚甲基茚-6-基丙酸酯的混合物;4-(2,6,6-三甲基-2-环己烯-1-基)-3-甲基-3-丁烯-2-酮;3,7-二甲基-2,6-壬二烯-1-腈;十二氢-3a,6,6,9a-四甲基萘并(2,1-b)呋喃;正十二烷二酸的乙二醇环酯;1-环十六碳烯-6-酮;1-环十七碳烯-10-酮;和玉米薄荷油。它们还可以包括1-环己基乙-1-基丁酸酯;1-环己基乙-1-基乙酸酯;1-环己基乙-1-醇;1-(4’-甲基乙基)环己基乙-1-基丙酸酯;和2’-羟基-1’-乙基(2-苯氧基)乙酸酯,其中每种化合物由国际香料和香精公司(International Flavors&Fragrances Inc)以商标VEILEX销售。更合适的恶臭中和剂是含有α-酮、苯甲醛或α,β-不饱和羰基部分的聚合物,诸如在美国申请公开2012/0294821、2013/0101544和2013/0101545中描述的那些。
本发明的香精谐香剂定义了一组香精成分,与常规的物理化学知识、香料专业知识和常规实践相反,其通过人类鼻子更快地被检测到,具有增强的初始香味喷发和香味喷发/空间填充感官性能。本发明的香精谐香剂还显示出诸如改善的恶臭覆盖率,卫生、抗菌、清新和/或清洁属性的益处。鉴于香精谐香剂获得的更高水平的性能,可以将更少量的香精(例如,10-30%的常规香精)配料到产品制剂中,从而减少环境负荷以及过敏原问题。另外,许多1类香精成分可从天然可再生资源(例如,来自发酵过程或通过植物材料的简单提取)获得。
本发明的高强度香味喷发香精谐香剂可以原样(即“净”)使用,或在香精配方中以0.1%至25%配料以产生完整的配方体系。有利地,单独的香精谐香剂和完整的配方体系两者在相同或更低剂量水平下都能够具有等同于或高于同类最佳配方的扩散速度、气味性能和/或香味喷发/空间填充强度。
备选地,本发明的高强度香味喷发香精谐香剂可以囊封在递送系统中。存在各种各样的囊封材料,所述囊封材料允许在清洁或调理过程中的不同时间输送香精。合适的囊封材料包括淀粉、低聚糖、环糊精、聚乙烯、聚酰胺、聚苯乙烯、聚异戊二烯、聚碳酸酯、聚酯、聚丙烯酸酯、乙烯基聚合物聚氨酯、无定形二氧化硅、沉淀二氧化硅、煅制氧化硅二氧化硅、硅铝酸盐如沸石和氧化铝,以及它们的混合物。在囊封材料包括无定形二氧化硅、沉淀二氧化硅、煅制二氧化硅或硅铝酸盐如沸石和氧化铝的情况下,孔体积为至少0.1ml/g并且包括直径为0.4-10nm的孔。合适的递送系统包括在WO 2015/023961、WO 2014/011860、US 7,196,049、US 2007/0138674、US 2014/0044760、US 2014/0044761、US 2014/0287008和US2013/0330292中描述的那些递送系统。
本发明的一个具体方面是提供高强度的、消费者可接受的香精,其适用于消费品,包括液体洗涤剂、粉末洗涤剂、条皂等。作为次要益处,香精谐香剂提供增强的恶臭覆盖,优异的卫生,清新和清洁的消费者属性,和/或由于本发明使用较低剂量的可能性而可能较少的环境和过敏原影响。因此,本发明还提供一种织物护理产品,其含有有效量的本文公开的高强度香味喷发香精谐香剂和未加香精的织物护理产品基料。在一些实施方案中,高强度香味喷发香精谐香剂提供了:对于扩散速度和香味喷发/空间填充的增强的香味喷发强度;增加的恶臭覆盖/减少;清新和清洁的香味感官特性和/或卫生/抗菌特性。
消费品可以以0.01至20重量%(例如,0.02至10重量%、0.05至5重量%、0.05至2重量%、0.1至0.5重量%)的水平含有上述任何香精谐香剂,其中下限可以是0.01、0.02、0.05、0.1、0.2或0.5重量%,并且上限可以是20、15、10、8、6、5、3、2、1、0.8或0.5重量%。
本发明的织物护理产品旨在包括粉末洗涤剂产品、液体洗涤剂产品或织物调理剂产品。例如,美国专利号5,840,668、5,227,084、6,080,711、5,443,751和5,500,153中描述了粉末衣物洗涤剂(机器和手洗)。液体衣物洗涤剂包括在美国专利号5,929,022、5,916,862、5,731,278、5,565,145、5,470,507、5,466,802、5,460,752、5,458,810、5,458,809、5,288,431、5,194,639、4,968,451、4,597,898、4,561,998、4,550,862、4,537,707、4,537,706、4,515,705、4,446,042和4,318,818中描述的那些系统。例如,美国专利号5,652,206、6,949,500、6,593,289、4,446,032和9,150,819中描述了织物柔顺剂和调理剂产品。
应用。本发明的香精谐香剂(作为净油或囊封于递送系统中)良好适合于但不限于在以下产品中使用:
a)家居产品
i.可以利用本发明的液体或粉末衣物洗涤剂包括在美国专利号5,929,022、5,916,862、5,731,278、5,565,145、5,470,507、5,466,802、5,460,752、5,458,810、5,458,809、5,288,431、5,194,639、4,968,451、4,597,898、4,561,998、4,550,862、4,537,707、4,537,706、4,515,705、4,446,042和4,318,818中描述的那些系统。
ii.单位剂量小袋、片剂和胶囊,如在EP 1 431 382 A1、US 2013/0219996 A1、US2013/0284637 A1和US 6,492,315中描述的那些。这些单位剂量制剂可以含有高浓度的功能材料(例如,5-100%织物柔软剂或洗涤剂活性成分)、香精(例如,0.5-100%、0.5-40%和0.5-15%)和香料(例如,0.1-100%、0.1-40%和1-20%)。它们可以不含有水以将水含量限制为低至小于30%(例如,小于20%,小于10%和小于5%)。
iii.增味剂(Scent Booster),如在US 7,867,968、US 7,871,976、US 8,333,289、US 2007/0269651 A1和US2014/0107010 A1中描述的那些。
iv.织物护理产品如漂洗调理剂(含有1至30重量%的织物调理活性成分),织物液体调理剂(含有1至30重量%的织物调理活性成分),滚筒式干衣机片板(Tumble DrierSheet),织物清新剂,织物清新剂喷雾剂,熨烫水和织物柔顺剂系统,如在美国专利号6,335,315、5,674,832、5,759,990、5,877,145、5,574,179、5,562,849、5,545,350、5,545,340、5,411,671、5,403,499、5,288,417、4,767,547和4,424,134中描述的那些。
液体织物柔顺剂/清新剂含有至少一种织物柔软剂,所述织物柔软剂优选以1至30%(例如,4至20%,4至10%和8至15%)的浓度存在。活性材料和织物柔软剂之间的比率可以为1:500至1:2(例如,1:250至1:4和1:100至1:8)。作为实例,当织物柔软剂按织物柔顺剂的重量计为5%时,活性材料为0.01至2.5%、优选0.02至1.25%并且更优选0.1至0.63%。作为另一个实例,当织物柔软剂按织物柔顺剂的重量计为20%时,活性材料为0.04至10%,优选0.08至5%并且更优选0.4至2.5%。活性材料是香精、恶臭中和剂或其混合物。液体织物柔顺剂可以具有0.15至15%的胶囊(例如,0.5至10%、0.7至5%和1至3%)。当以这些水平包括胶囊时,柔顺剂中的净油当量(NOE)为0.05至5%(例如,0.15至3.2%、0.25至2%和0.3至1%)。合适的织物柔软剂包括阳离子型表面活性剂。非限制性实例有季铵化合物如烷基化季铵化合物,环或环状季铵化合物,芳族季铵化合物,二季铵化合物,烷氧基化季铵化合物,酰氨基胺季铵化合物,酯季铵化合物,及其混合物。织物柔软组合物,及其组分,一般地描述于US 2004/0204337和US 2003/0060390中。合适的柔软剂包括酯季铵盐(esterquats),如可商购得自Evonik Industries的Rewoquat WE 18和可商购得自Stepan公司的Stepantex SP-90。
v.液体碗碟洗涤剂如在美国专利号6,069,122和5,990,065中描述的那些。
vi.自动碗碟洗涤剂如在美国专利号6,020,294、6,017,871、5,968,881、5,962,386、5,939,373、5,914,307、5,902,781、5,705,464、5,703,034、5,703,030、5,679,630、5,597,936、5,581,005、5,559,261、4,515,705、5,169,552和4,714,562中描述的那些。
vii.通用清洁剂,包括桶装可稀释清洁剂和卫生间清洁剂
viii.浴厕清洁剂
ix.浴巾(Bath Tissue)
x.地毯除臭剂
xi.蜡烛
xii.房间除臭剂
xiii.地板清洁剂
xiv.消毒剂
xv.窗户清洁剂
xvi.垃圾袋/垃圾桶内衬
xvii.空气清新剂,包括房间除臭剂和车辆除臭剂、香薰蜡烛、喷雾剂、香油空气清新剂、自动喷雾空气清新剂和中和凝胶珠xviii.水分吸收剂
xix.家用装置如纸巾和一次性擦拭巾
xx.蛾丸/诱捕剂/饼(Moth balls/traps/cakes)
b)婴儿护理产品
i.尿布疹乳膏/护臀膏
ii.婴儿爽身粉
c)婴儿护理装置
i.尿不湿
ii.围嘴
iii.擦拭巾
d)口腔护理产品。牙齿护理产品(作为用于口腔护理的根据本发明的制备物的实例)通常包括磨料体系(磨料或抛光剂),例如硅酸、碳酸钙、磷酸钙、铝氧化物和/或羟磷石灰,表面活性物质,例如月桂基硫酸酯钠、月桂基肌氨酸酯钠和/或椰油酰胺基丙基甜菜碱,润湿剂,例如甘油和/或山梨糖醇,增稠剂,例如羧甲基纤维素、聚乙二醇、角叉菜胶和/或LaponiteTM,甜味剂,例如糖精,用于令人不愉快的味道感觉的味觉矫正剂,用于另外的通常不是令人不愉快的味道感觉的味觉矫正剂,味觉调节物质(例如肌醇磷酸酯,核苷酸如单磷酸鸟苷、单磷酸腺苷,或者其他物质如谷氨酸钠或2-苯氧丙酸),凉爽活性成分,例如薄荷醇衍生物(例如L-乳酸薄荷酯、L-薄荷基烷基碳酸酯、薄荷酮缩酮、薄荷烷羧酸酰胺)、2,2,2-三烷基乙酸酰胺(例如2,2-二异丙基丙酸甲基酰胺)、icilin和icilin衍生物,稳定剂和活性成分,例如氟化钠、单氟磷酸钠、二氟化锡、季铵氟化物、柠檬酸锌、硫酸锌、焦磷酸锡、二氯化锡、多种焦磷酸盐的混合物、三氯生、鲸蜡基吡啶鎓盐氯化物、乳酸铝、柠檬酸钾、硝酸钾、氯化钾、氯化锶、过氧化氢、调味品和/或碳酸氢钠或味觉矫正剂。
i.牙膏。一种示例性制剂如下:
1.磷酸钙 40-55%
2.羧甲基纤维素 0.8-1.2%
3.月桂基硫酸酯钠 1.5-2.5%
4.甘油 20-30%
5.糖精 0.1-0.3%
6.香料油 1-2.5%
7.水,足量至100%
一种用于制备该制剂的典型方法包括以下步骤:(i)通过共混机混合根据前述的制剂以提供牙膏,和(ii)添加本发明的组合物并且将所得混合物共混直至均匀。
ii.牙粉
iii.漱口水
iv.牙齿增白剂
v.义齿粘附剂
e)保健设备
i.牙线
ii.牙刷
iii.呼吸器
iv.香薰/调味避孕套
f)妇女卫生保健品如卫生棉塞、卫生巾和擦拭巾,以及护垫
g)个人护理产品:美容或药物制剂,例如,“油包水”(W/O)型乳液,“水包油”(O/W)型乳液或作为例如水包油包水(W/O/W)型的多相乳液,作为PIT乳液、皮克林乳液(Pickering emulsion)、微乳液或纳米乳液;并且特别优选的乳液是“水包油”(O/W)型或水包油包水(W/O/W)型。更具体地,
i.个人清洁剂(条皂,沐浴液和沐浴露)
ii.沐浴护理剂(In-shower conditioner)
iii.防晒和纹身护色(Sunscreen ant tattoo color protection)(喷雾剂,洗剂和棒(sticks))
iv.驱昆虫剂
v.洗手液
vi.抗炎香油、软膏和喷雾剂
vii.抗菌软膏和乳膏
viii.感知剂(Sensates)
ix.除臭剂和止汗剂,包括气溶胶和泵喷止汗剂,棒式止汗剂(stickantiperspirant),滚抹式止汗剂、乳液喷雾止汗剂、透明乳液棒式止汗剂、软固体止汗剂、乳液滚抹式止汗剂、透明乳液棒式止汗剂、不透明乳液棒式止汗剂、透明凝胶止汗剂、透明棒式除臭剂、凝胶除臭剂、喷雾除臭剂、滚抹式和乳膏除臭剂。
x.基于蜡的除臭剂。一种示例性制剂如下:
1.石蜡(Parafin Wax)10-20%
2.烃蜡5-10%
3.白矿脂10-15%
4.乙酰化的羊毛脂醇2-4%
5.己二酸二异丙酯4-8%
6.矿物油40-60%
7.防腐剂(根据需要)
该制剂通过以下制备:(i)混合上述成分,(ii)将得到的组合物加热至75℃直至熔化,(iii)在搅拌下,添加4%低温研磨的包含香精的聚合物同时保持温度为75℃,和(iv)搅拌得到的混合物以确保均匀的悬浮液同时将本发明的组合物添加至制剂。
xi.二醇/皂型除臭剂。一种示例性制剂如下:
1.丙二醇60-70%
2.硬脂酸钠5-10%
3.蒸馏水20-30%
4. 2,4,4-三氯-2'-羟基二苯基醚,由Ciba-Geigy Chemical Company制造,并且商标是Ciba-Geigy Chemical Company)0.01-0.5%
将各成分合并,并在搅拌下加热至75℃直到硬脂酸钠溶解。
将得到的混合物冷却至40℃,然后添加本发明的组合物。
xii.乳液,包括身体乳液、面部乳液和手部乳液
xiii.爽身粉和足粉
xiv.洗漱用品
xv.身体喷雾剂
xvi.剃须膏和男性美容产品
xvii.浸浴用品
xviii.去角质磨砂膏
h)个人护理装置
i.面巾
ii.清洁擦拭巾
i)头发护理产品
i.洗发剂(液体和干粉)
ii.护发剂(洗去型护理剂,保留型护理剂和清洁型护理剂)
iii.染发剂
iv.头发清新剂
v.头发香料
vi.头发拉直产品
vii.头发造型产品、头发固定和定型助剂
viii.头发梳理乳膏
ix.发蜡
x.头发发泡剂、发胶、非气溶胶泵喷剂
xi.头发漂白剂、染料和着色剂
xii.烫发剂
xiii.头发擦拭巾
j)美容护理
i.精制香精-含酒精的。用于将香精胶囊掺入到含酒精的精制香精中的组合物和方法在US 4,428,869中描述。含酒精的精制香精可以含有以下:
1.乙醇(1-99%)
2.水(0-99%)
3.悬浮助剂,包括但不限于:羟丙基纤维素、乙基纤维素、二氧化硅、微晶纤维素、角叉菜胶、藻酸丙二醇酯、甲基纤维素、羧甲基纤维素钠或黄原胶(0.1-1%)
4.任选地,乳化剂或软化剂可以被包括到但不限于以上列出的那些
ii.固体香料
iii.唇膏/润唇膏
iv.化妆清洁剂
v.护肤化妆品如粉底、面膜、防晒霜、润肤乳液、乳状乳液、润肤霜、软化剂、皮肤美白剂
vi.美容化妆品,包括美甲、睫毛膏、眼线膏、眼影、液体粉底、粉末粉底、唇膏和腮红
k)消费品包装如香味盒、香味塑料瓶/箱
l)宠物护理产品
i.猫砂
ii.跳蚤和蜱处理产品
iii.宠物美容产品
iv.宠物洗发剂
v.宠物玩具、招待物(treats)和咀嚼物
vi.宠物训练垫
vii.宠物笼和箱
除非另外指明,则在本文和在权利要求中提到的所有份、百分比和比例都是以重量计的。
本文公开的值和尺寸不被理解为严格限于所记载的精确数值。而是,除非另外详细说明,每个这样的值都旨在意指所记载的值和在该值附近的功能等同范围两者。例如,作为“50%”公开的值旨在意指“约50%”。
香精成分的混合物是香精和香料领域的技术人员已知的“谐香剂”。如本文中使用的术语“谐香剂”定义为“两种以上‘香精成分’的混合物,其巧妙地组合以赋予令人愉悦的香味、气味、香气或香精特征。”
如本文中使用的术语香精成分或组合物被视为限定了天然和合成来源的多种香精材料。为了本发明的目的,“香精成分”在本文中被定义为分子量为至少为100g/mol并且可用于单独地或与其他“香精成分”组合地赋予气味、香精、香气或香味的化合物。它们包括单一化合物以及挥发性和有气味的混合物,呈液体或固体形式,为亲水性或疏水性的。具体的实例可以在当前的文献中找到,例如,S.Arctander的Perfume and Flavor Chemicals,Montclair N.J.(USA);M.B.Jacobs的Fenaroli’s Handbook of flavour Ingredients,CRC Press or Synthetic Food Adjuncts,van Nostrand Co.,Inc.;Steffen ArctanderAllured Pub.Co.(1994)和“Perfumes:Art,Science and Technology”;以及Muller,P.M.和Lamparsky,D.,Blackie Academic and Professional(1994)。
术语“g”、“mg”和“μg”分别是指“克”、“毫克”和“微克”。术语“L”和“mL”分别是指“升”和“毫升”。术语“cm”是指“厘米”。术语“cm/秒”和“cm/s”二者都是指“厘米/秒”。
通过以下非限制性实例更详细地描述本发明。在没有进一步阐释的情况下,据信基于本文中的描述,本领域技术人员可以利用本发明至其最充分程度。本文中引用的所有出版物以其整体通过引用并入。
实施例1-3
使用典型的香精探针作为比较香精谐香剂来进行测试。探针包括0.7重量%的1类香精成分(即,二苯醚、玫瑰醚、manzanate和galbascone),20.7重量%的2类香精成分(即,二苯醚、(2R,4S)-4-甲基-2-(2-甲基丙-1-烯-1-基)四氢-2H-吡喃、2-甲基戊酸乙酯和1-(5,5-二甲基环己-1-烯-1-基)戊-4-烯-1-酮)、20.7重量%的2类香精成分(即,2-甲氧基萘、3a,4,5,6,7,7a-六氢-1H-4,7-亚甲基茚-5-基丙酸酯、(E)-3-甲基-4-(2,6,6-三甲基环己-2-烯-1-基)丁-3-烯-2-酮、4-甲氧基苯甲醛、十二醛、(E)-4-甲基癸-3-烯-5-醇和(1S,2R)-2,4-二甲基环己-3-烯-1-甲醛),78.4%的3类香精成分,和0.2重量%精油。
按照本文定义的规格制备本发明的三种香精谐香剂(谐香剂A、B和C)。
谐香剂A含有9%的1类香精成分(即,1-(5,5-二甲基环己-1-烯-1-基)戊-4-烯-1-酮、二苯醚、苯甲酸甲酯、1,3,3-三甲基-2-氧杂二环[2.2.2]辛烷、2-甲基丁酸乙酯、2-氨基苯甲酸甲酯),13.95%的2类香精成分(即,2-甲氧基萘、(E)-十三碳-2-烯腈、3a,4,5,6,7,7a-六氢-1H-4,7-亚甲基茚-5-基丙酸酯、(E)-4-(2,6,6-三甲基环己-1-烯-1-基)丁-3-烯-2-酮、(E)-3-甲基-4-(2,6,6-三甲基环己-2-烯-1-基)丁-3-烯-2-酮、4-甲氧基苯甲醛、十二醛、(E)-4-甲基癸-3-烯-5-醇、(1R,2R,4R)-1,7,7-三甲基二环[2.2.1]庚-2-醇、(E)-1-甲氧基-4-(丙-1-烯-1-基)苯、3,7-二甲基辛-6-烯腈、(1S,2R)-2,4-二甲基环己-3-烯-1-甲醛、松木超级精华),70.55%的3类香精成分如4,7-亚甲基-1H-茚酚、3a,4,5,6,7,7a-六氢-,乙酸酯、1-2,6,6-三甲基-3-环己烯-1-基-2-丁烯-1-酮,和6.50%精油(即,罗勒油、紫罗兰叶净油、葡萄柚油)。
谐香剂B含有13.65%的1类香精成分(即,2-氨基苯甲酸甲酯、1-(5,5-二甲基环己-1-烯-1-基)戊-4-烯-1-酮、4-亚甲基-2-苯基四氢-2H-吡喃、二苯醚、苯甲酸甲酯、(2R,4S)-4-甲基-2-(2-甲基丙-1-烯-1-基)四氢-2H-吡喃、(2-甲氧基乙基)苯、二戊烯、1,3,3-三甲基-2-氧杂二环[2.2.2]辛烷、(1R,2R,4R)-二环[2.2.1]庚-5-烯-2-甲酸乙酯、2-异丁基-3-甲氧基吡嗪、1-甲氧基-4-甲苯、(3aR,8bS)-2,2,6,6,7,8,8-七甲基十氢-2H-茚并[4,5-b]呋喃),61.40%的2类香精成分(即,2-甲氧基萘、十三烯-2-腈、3a,4,5,6,7,7a-六氢-1H-4,7-亚甲基茚-5-基丙酸酯、(E)-4-(2,6,6-三甲基环己-1-烯-1-基)丁-3-烯-2-酮、(E)-3-甲基-4-(2,6,6-三甲基环己-2-烯-1-基)丁-3-烯-2-酮、4-甲氧基苯甲醛、十二醛、3-甲基-2-戊基环戊-2-烯-1-酮、(1R,2R,4R)-1,7,7-三甲基二环[2.2.1]庚-2-醇、(E)-十一碳-9-烯醛、(E)-1-甲氧基-4-(丙-1-烯-1-基)苯、3,7-二甲基辛-6-烯腈、3,7-二甲基辛-1,6-二烯-3-醇、(1S,2R)-2,4-二甲基环己-3-烯-1-甲醛、辛醛、松木超级精华),13.21%的3类香精成分如trisamber和ald c-12MNA,和11.74%精油(即,罗勒油、丁香叶油、橙叶油)。
谐香剂C含有71.58%的1类香精成分(即,1-(5,5-二甲基环己-1-烯-1-基)戊-4-烯-1-酮、4-亚甲基-2-苯基四氢-2H-吡喃、二苯醚、1,3,3-三甲基-2-氧杂二环[2.2.2]辛烷、己酸乙酯、2-甲基丁酸乙酯、(1R,2R,4R)-二环[2.2.1]庚-5-烯-2-甲酸乙酯、噻唑(2-异丙基4-甲基)、2-异丁基-3-甲氧基吡嗪),25.46%的2类香精成分(即,(E)-4-(2,6,6-三甲基环己-2-烯-1-基)丁-3-烯-2-酮、2-甲氧基萘、3a,4,5,6,7,7a-六氢-1H-4,7-亚甲基茚-5-基丙酸酯、(E)-4-(2,6,6-三甲基环己-1-烯-1-基)丁-3-烯-2-酮、十二醛、(E)-4-甲基癸-3-烯-5-醇、3,7-二甲基辛-6-烯腈、3-(4-甲基环己-3-烯-1-基)丁醛、3,7-二甲基辛-1,6-二烯-3-醇、(1S,2S)-2-(叔丁基)环己-1-醇、2,6-二甲基庚-5-烯醛、(1S,2R)-2,4-二甲基环己-3-烯-1-甲醛、辛醛、1-甲基-4-(亚丙-2-基)环己-1-烯、松木超级精华),0.06%的3类香精成分,和2.9%精油(即,甜橙醛油和紫罗兰叶净油)。
将标准香精探针用作比较,并且还用作稀释谐香剂A、B和C的基料。使用可商购获得的香精产品(即淀粉囊封的香精基准)作为比较。
香精谐香剂A、B和C中的每一种在标准香精探针中以25%配料以产生完整配方体系A、B和C(即,25%香精谐香剂A、B或C+75%标准香精探针)。三种完整配方体系中的每一种以0.3%和0.2%配料至未加香精的粉末洗涤剂基料中。由六名评判员的小组对加入香精的粉末洗涤剂(即,香精谐香剂+香精探针+未加香精的粉末基料)的扩散速度、香味强度进行评价。此外,将香精谐香剂(以0.1%配料)与淀粉囊封的香精基准和标准香精探针(净油)进行比较。经由培训过的感官小组筛选所述三种完整配方体系的扩散速度和香味强度。在香味强度筛选中,以0至100的标记量表等级(Labeled Magnitude Scale,LMS)评价每种香精谐香剂。评分为5表明香精谐香剂具有弱的气味,评分为17表明中等气味,并且评分高于35表明非常强的气味。将完整配方体系与总产品制剂基准(其含有净油(0.2%)加上淀粉囊封的香精基准(0.05%NOE))进行比较,并且还针对标准香精探针(0.1%的净油)进行比较。呈现的所有统计结果通过ANOVA评价,考虑95%的置信水平。
扩散速度。对老化样品(例如,老化2周)的该分析的结果显示,与参考香精探针和香精淀粉探针相比,所有三种香精谐香剂都具有增强的扩散速度性能。此外,出乎意料的是,所述三种香精谐香剂显示出比基准产品显著更好的扩散速度。谐香剂A、B和C的香味强度分别为29.13、22.91和28.39。相比之下,标准香精探针的香味强度为16.17,并且淀粉囊封的香精基准的香味强度为18.45。关于扩散速度,谐香剂A、B和C的扩散速度分别为3.79秒、4.44秒和4.18秒。作为比较,标准香精探针和淀粉囊封的香精基准的扩散速度分别为4.74秒和5.74秒。
就所述三种完整香精系统而言,当与香精探针和基准产品相比时,观察到同等水平的扩散速度(一种完整香精系统也具有更快的扩散速度)。
香味强度。结果显示,所有三种香精谐香剂都具有比参考香精探针显著更高的香味强度。
此外,观察到所有三种完整香精系统A、B和C具有比标准香精探针显著更高的香味强度,并且与含有香精净油和淀粉囊封香精的基准产品相比是等同的。
以0.3%配料粉末洗涤剂基料中时,完整香精系统A、B和C的香味强度分别为18.78、16.95和18.79,并且扩散速度为4.47、4.09和4.56秒。基准产品的香味强度为18.45并且扩散速度为5.74。
以0.2%配料粉末洗涤剂基料中时,完整香精系统A、B和C的香味强度分别为16.07、15.06和16.43。
该结果是出乎意料的,因为基准含有香精净油加上囊封技术(淀粉),本领域已知其在与水相接触时在浸泡/香味喷发阶段提供显著改善的香味性能(对于老化样品,由于香精成分对消费品基料的化学保护)。此外,观察到含有作为净油的香味喷发香精谐香剂的任何完整香精系统具有与基准产品等同的香味性能强度,所述基准产品是完全香精系统(含有净油加上囊封技术)。
分析顶空测量。通过标准化分析动态顶空方法测量香精探针+谐香剂(谐香剂25%,探针75%,以0.1%的总剂量)的顶空,并且显示出在将加入香精的粉末洗涤剂溶解在水中后的短时间和长时间都比单独的探针(以0.1%配料)具有显著更高量的顶空分子。此外,使用气味值概念(OV)由测量的峰面积计算气味强度。可以在文献中找到关于OV模型及其对香精制剂和感官知觉的适用性的细节。参见M.Teixeira等人,Perfume Engineering:Design,Performance&Classification,BH Elsevier,Oxford,UK,2013。通过这种方法,还观察到香精探针+谐香剂的气味的计算强度显著高于单独的探针,因此验证了分析测量。这显示出本文公开的谐香剂的增强的香味性能的方面的益处。
恶臭覆盖。也使用恶臭覆盖/抗菌性质数据库来设计香精谐香剂。在这方面,制剂中包括具有恶臭覆盖和抗菌性质的特定香精材料(例如,松木超级精华、3,7-二甲基辛-1,6-二烯-3-醇、3,7-二甲基辛-3-醇和3-乙氧基-4-羟基苯甲醛等)。例如,已经发现含有≥0.05%的至少一种US 6,495,512中公开的抗菌/香料组合物的香料组合物可以用于在具有泥土、霉味和生材底调时赋予有趣的草本、柑橘、芳香、花香、甜味和香草醛香气,同时具有抗菌性质。该分析的结果显示,相对于柑橘油基准,含有恶臭中和剂的两种香精谐香剂显著增强了对霉病和汗液的恶臭覆盖水平。
卫生/抗菌。香精谐香剂可以含有上述抗菌成分。对于合适的抗菌成分的列表,参见US 6,495,512。已经发现含有≥0.05%的至少一种抗菌剂的本发明香精谐香剂可以用于赋予吸引人的香气,同时具有抗菌性质。对于大肠杆菌(e.coli)、海氏肠球菌(e.hirae)、金黄色葡萄球菌(s.aureos)和其他细菌具有高抗菌活性的香料成分包括1-甲氧基-4-甲苯、3,7-二甲基辛-1,6-二烯-3-醇和松木超级精华等。
实施例4和5
通过使用(i)8.1%的四种1类成分:玫瑰醚、galbascone、tropicalia和丁酸乙基-2-甲酯,制备本发明的谐香剂D。
通过向75份香精Serena(可从International Flavors&Fragrances,UnionBeach,NJ商购获得)中加入5份谐香剂D,制备本发明的香精1。香精Serena仅含有0.375%的1类成分,并且用作对照。
通过将香精1以1%的水平配料到未加香精的模型洗发剂基料中,制备本发明的洗发剂组合物1。在评价之前,将洗发剂组合物在室温下浸渍至少24小时。
通过以与洗发剂组合物1相同的剂量混合香精Serena和无香味的洗发剂基料,制备比较洗发剂组合物。
洗发剂性能
将洗发剂组合物1和比较洗发剂组合物各自施加至湿发样品上,挤出过量的水。然后使头发样本起泡并且用水冲洗。
培训过的评判员小组以范围为0至100的等级对香味强度进行评价。数值5表明头发样本产生弱的强度,而值30表明头发样本产生非常强的气味。
出乎意料的是,用洗发剂组合物1处理的头发样品在香味喷发阶段具有13.6的香味强度,而用比较洗发剂组合物处理的头发样品具有12.6的香味强度。
实施例6-8
制备本发明的三种香精谐香剂,即谐香剂E、F和G。
谐香剂E含有9%的1类成分。
谐香剂F含有11%的1类成分。
谐香剂G含有13%的1类成分。
除了1类成分的量不同以外,谐香剂E、F和G含有相同的香精成分。参见下表3。
使用与谐香剂E相同的香精成分但是仅具有5%的1类成分,制备比较谐香剂2’。
表3
扩散速度
按照上述方案,测量谐香剂E、F、G和比较2’的扩散速度。
谐香剂E、F和G各自的扩散速度为2.88秒、2.72秒和2.81秒。比较2’的扩散速度为3.2秒。
实施例9和10
通过向模型香精Ariel Sunrise(可从IFF,Hilversum,荷兰,商购获得)中加入11%的谐香剂E,制备本发明的香精E。香精Ariel Sunrise含有4.2%的1类成分。香精E含有5%的1类成分。
通过向无香味的模型粉末洗涤剂中加入0.1%的香精E,制备本发明的粉末洗涤剂组合物E。通向加入0.1%的香精Ariel Sunrise来代替香精E,制备比较洗涤剂4’。
对香味强度和扩散速度进行评价。组合物E的香味强度为22.55并且扩散速度为2.33秒。比较洗涤剂4’的香味强度为17.87并且扩散速度为2.81秒。
实施例11
通过向Ariel Sunrise中加入7%的谐香剂F来制备本发明的香精F,其具有5.73%的1类成分。
将香精F和Ariel Sunrise中的每一种以1%加入至无香味的模型液体洗涤剂中。含有香精F的液体洗涤剂比含有Ariel Sunrise的液体洗涤剂具有更快的香味喷发香味。
还将香精F和Ariel Sunrise中的每一种以1%加入至无香味的织物调理剂中。与Ariel Sunrise相比,香精F显示出提高的香味喷发速度和强度。
实施例12
通过混合模型香精Thunder(可从IFF,Hilversum,荷兰,商购获得),制备本发明的香精FA。香精FA含有8.3%的1类成分。香精Thunder含有5.3%的1类成分。
使用香精FA,按照EP 1 797 946 B1中描述的程序,制备微胶囊FA。
除了使用香精Thunder以外,按照相同的程序制备比较微胶囊4’。
在液体洗涤剂衣物应用中评价这两个微胶囊。相比于比较微胶囊4’,微胶囊FA显示出提高的香味喷发速度以及香味强度。
实施例13-20
使用各种量的1类成分制备本发明的四种香精谐香剂,即谐香剂I、J、K和L。
谐香剂I含有10.2重量%的1类成分(例如,1,3,3-三甲基-2-氧杂二环[2.2.2]辛烷、2-甲基丁酸乙酯、2-氨基苯甲酸甲酯、1-甲基-4-(丙-1-烯-2-基)环己-1-烯、(2R,4S)-4-甲基-2-(2-甲基丙-1-烯-1-基)四氢-2H-吡喃、苯甲酸甲酯和1-甲氧基-4-甲苯)和9.8重量%的2类成分。
谐香剂J含有54重量%的1类成分(例如,2-甲基丁酸乙酯、1-(5,5-二甲基环己-1-烯-1-基)戊-4-烯-1-酮)和10重量%的2类成分。
谐香剂K含有10.2重量%的1类成分(例如,二苯醚、己酸乙酯、1-(5,5-二甲基环己-1-烯-1-基)戊-4-烯-1-酮、2-(3-苯基丙基)吡啶、(2R,4S)-4-甲基-2-(2-甲基丙-1-烯-1-基)四氢-2H-吡喃、2-氨基苯甲酸甲酯、(1R,2R,4R)-二环[2.2.1]庚-5-烯-2-甲酸乙酯、4-亚甲基-2-苯基四氢-2H-吡喃)和10重量%的2类成分。
谐香剂L含有46重量%的1类成分(例如,二苯醚、(2R,4S)-4-甲基-2-(2-甲基丙-1-烯-1-基)四氢-2H-吡喃、4-亚甲基-2-苯基四氢-2H-吡喃)和22.2重量%的2类成分。
使用香精Happy Luxury或Healthy Life(可从International Flavors&Fragrances,Union Beach,New Jersey商购获得的两种香精)制备本发明的四种香精,即香精I-L。香精Happy Luxury含有0.1重量%的1类成分和12.95重量%的2类成分。香精Healthy Life含有2.6重量%的1类成分和6.1重量%的2类成分。
通过混合80重量%的Happy Luxury与20重量%的谐香剂I或谐香剂J,分别制备香精I和J。
通过混合80重量%的Healthy Life与20重量%的谐香剂K或谐香剂L,分别制备香精K和L。
将香精I-L中的每一种以1重量%净油分别地加入至IFF棕榈基料条皂中。在感官测试之前,将条皂老化7天。
将两种香精Happy Luxury和Healthy Life用作对照。
由培训过的评判员的小组以0-100的等级评价条皂的香味喷发香味强度。评分为5以下表明香精或成分具有弱的气味。评分为15表明中等气味。评分为35表明强的气味。
下表4中示出了香味喷发香味强度结果。
表4
香精 | 香味喷发评分 |
香精I | 24.59 |
香精J | 25.54 |
Happy Luxury | 19.33 |
香精I | 23.99 |
香精J | 24.44 |
Happy Luxury | 19.46 |
实施例21-24
使用香精Solitaire(可从International Flavors&Fragrances,Union Beach,New Jersey商购获得)制备本发明的四种香精,即香精M、N、O和P。香精Solitaire含有0.14重量%的1类成分和16.8重量%的2类成分。
通过混合95重量%的Solitaire与5重量%的谐香剂I、J、K或L,分别制备香精M-P中的每一种。将香精Solitaire用作对照。
将四种香精中的每一种以1.5重量%的水平加入至模型沐浴露中,由培训过的评判员的小组以0-100的等级评价沐浴露的香味喷发香味强度。评分为15以下表明香精或成分具有弱的气味。评分为20至40表明中等气味。评分高于40表明强的气味。
下表5中示出了香味喷发香味强度结果。
表5
其他实施方案
本说明书中公开的所有特征都可以以任意组合合并。本说明书中公开的每个特征都可以被用作相同、等同或相似目的的备选特征替换。因此,除非另外明确说明,公开的每个特征都仅是等同或相似特征的通用系列的实例。
实际上,为了达到设计高性能的香味喷发谐香剂或组合物的目的,本领域技术人员可以选择不同的成分并且改变它们的浓度。
根据以上描述,技术人员可以容易地确定本发明的必要特征,并且在不脱离其实质和范围的情况下,可以对本发明进行多种变化和改变以使其适合于多种使用和条件。
Claims (15)
1.一种高强度香味喷发香精谐香剂,其包含:
(i)至少7重量%的一种或多种1类香精成分,
(ii)5至93重量%的一种或多种2类香精成分,
其中
所述1类香精成分各自具有8.5cm/秒以上的实验速度,并且其中所述1类香精成分各自具有:(i)选自由以下组成的组的至少八个原子:碳原子、氢原子、氧原子和氮原子;(ii)选自由以下组成的组的官能团:醛(-CHO)、羟基(-OH)、烯烃(C=C)、醚(-O-)、酯(-C(O)O-)、苯基、呋喃基和吡嗪基基团;(iii)室温下0.0003至20mmHg的蒸汽压;(iv)范围在100至280原子质量单位内的分子量;以及(v)1至5.5的logP值,
所述2类香精成分各自具有小于8.5cm/秒且大于5cm/秒的实验速度,并且
所述香精谐香剂具有0.5至5的香味喷发香味强度指数。
2.根据权利要求1所述的香精谐香剂,其中所述1类香精成分各自具有大于5000焦耳的动能并且所述2类香精成分各自具有1400至5000焦耳的动能。
3.根据权利要求1所述的香精谐香剂,其还包含一种或多种恶臭中和剂,或者一种或多种抗菌剂。
4.根据权利要求1所述的香精谐香剂,其中所述1类香精成分、所述2类香精成分和所述3类香精成分的总和为100%。
5.根据权利要求1所述的香精谐香剂,其还包含精油。
6.根据权利要求1所述的香精谐香剂,其中所述香精谐香剂包含至少8重量%的两种以上1类香精成分。
7.根据权利要求1所述的香精谐香剂,其中所述香精谐香剂包含至少五种1类香精成分。
8.根据权利要求1所述的香精谐香剂,其中所述香精谐香剂包含5至70重量%的所述2类香精成分。
9.根据权利要求1所述的香精谐香剂,其中所述香精谐香剂包含20至100重量%的所述1类香精成分和2类香精成分。
10.一种递送系统,所述递送系统包含根据权利要求1所述的香精谐香剂。
11.一种消费品,所述消费品包含根据权利要求1所述的香精谐香剂。
12.根据权利要求11所述的消费品,其中所述香精谐香剂以按所述消费品的重量计0.005至10%的水平配料。
13.根据权利要求11所述的消费品,其中所述消费品是洗发剂、护发剂、染发剂、头发清新剂、头发固定或定型助剂、头发漂白剂、头发染料或着色剂、条皂、沐浴液、化妆品制备物、通用清洁剂、浴厕清洁剂、地板清洁剂、窗户清洁剂、浴巾、纸巾、一次性擦拭巾、尿布疹乳膏或护臀膏、婴儿爽身粉、尿不湿、围嘴、婴儿擦拭巾、口腔护理产品、牙膏、漱口水、牙齿增白剂、义齿粘附剂、洗手液、抗炎香油、抗炎软膏、抗炎喷雾剂、保健设备、牙线、牙刷、卫生棉塞、卫生巾、个人护理产品、防晒露、防晒喷雾剂、基于蜡的除臭剂、二醇型除臭剂、皂型除臭剂、面部乳液、身体乳液、手部乳液、爽身粉、剃须膏、浸浴用品、去角质磨砂膏、足霜、面巾、清洁擦拭巾、织物护理产品、织物柔顺剂、织物清新剂、熨烫水、液体衣物洗涤剂、粉末衣物洗涤剂、液体碗碟洗涤剂、自动碗碟洗涤剂、单位剂量片剂或胶囊、增味剂、干衣机片板、精制香精、固体香料、淡香水、香水、古龙水、无醇香料、香料粉末、香料蜡、香料乳液、粉末粉底、液体粉底、眼影、唇膏或润唇膏、淡香水产品、除臭剂、地毯除臭剂、蜡烛、房间除臭剂、消毒剂、漂白剂、气溶胶止汗剂、棒式止汗剂、滚抹式止汗剂、乳液喷雾止汗剂、透明乳液棒式止汗剂、软固体止汗剂、乳液滚抹式止汗剂、透明乳液棒式止汗剂、不透明乳液棒式止汗剂、透明凝胶止汗剂、透明棒式除臭剂、喷雾除臭剂、香料凝胶、香料乳液、香料乳膏、香料油、蜡、头发香料、布香料、除臭剂香料、起泡浴液、沐浴油、沐浴盐、沐浴囊、沐浴香料晶、沐浴香料片、香料宝石、香味聚合物或用于数字装置的香精组合物。
14.根据权利要求11所述的消费品,其中所述香精谐香剂以按所述消费品的重量计0.01至0.5%的水平配料,并且所述消费品是洗发剂、护发剂、条皂、沐浴液、通用清洁剂、织物调理剂、液体衣物洗涤剂或粉末衣物洗涤剂。
15.一种香精组合物,所述香精组合物包含5重量%以上的根据权利要求1所述的香精谐香剂。
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- 2017-10-16 MX MX2019004319A patent/MX2019004319A/es unknown
- 2017-10-16 EP EP17859463.6A patent/EP3525751A4/en active Pending
- 2017-10-16 CN CN201780062793.1A patent/CN109803632B/zh active Active
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WO2018071897A1 (en) | 2018-04-19 |
BR112019007090A2 (pt) | 2019-07-02 |
JP2020500227A (ja) | 2020-01-09 |
EP3525751A4 (en) | 2020-09-16 |
MX2019004319A (es) | 2019-06-12 |
CN109803632A (zh) | 2019-05-24 |
US20210207058A1 (en) | 2021-07-08 |
JP7069139B2 (ja) | 2022-05-17 |
EP3525751A1 (en) | 2019-08-21 |
CN109803632B (zh) | 2022-08-09 |
US10975327B2 (en) | 2021-04-13 |
US20190367837A1 (en) | 2019-12-05 |
BR112019007090B1 (pt) | 2022-08-16 |
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