CN115052899A - Pcsk9的单域抗体及其应用 - Google Patents
Pcsk9的单域抗体及其应用 Download PDFInfo
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- CN115052899A CN115052899A CN202080095724.2A CN202080095724A CN115052899A CN 115052899 A CN115052899 A CN 115052899A CN 202080095724 A CN202080095724 A CN 202080095724A CN 115052899 A CN115052899 A CN 115052899A
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Abstract
一种能够特异性识别PCSK9的抗体或其抗原结合片段。该抗体包括如SEQ ID NO:1、2和3或者与SEQ ID NO:1、2和3具有至少95％同一性的氨基酸序列所示的重链可变区CDR1、CDR2、CDR3序列。该抗体能够特异性结合PCSK9，抑制PCSK9的活性。
Description
PCT国内申请，说明书已公开。
Claims (27)
- PCT国内申请，权利要求书已公开。
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2020/074624 WO2021159235A1 (zh) | 2020-02-10 | 2020-02-10 | Pcsk9的单域抗体及其应用 |
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| CN115052899A true CN115052899A (zh) | 2022-09-13 |
| CN115052899B CN115052899B (zh) | 2024-04-19 |
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| CN116813781B (zh) * | 2023-07-29 | 2024-01-12 | 十堰市太和医院（湖北医药学院附属医院） | 一种靶向β2AR的纳米抗体及其制备方法和应用 |
| CN117843797A (zh) * | 2023-12-04 | 2024-04-09 | 康维众和(中山)生物药业有限公司 | 一组抗pcsk9的纳米抗体及其应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109897110A (zh) * | 2017-12-08 | 2019-06-18 | 深圳华大生命科学研究院 | 纳米抗体及其制备方法 |
| US20190233542A1 (en) * | 2016-09-20 | 2019-08-01 | WuXi Biologics Ireland Limited | Novel Anti-PCSK9 Antibodies |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013091103A1 (en) * | 2011-12-20 | 2013-06-27 | Adaerata, Limited Partnership | Single domain antibodies as inhibitors of pcsk9 |
| US20200165354A1 (en) * | 2016-09-20 | 2020-05-28 | WuXi Biologics Ireland Limited | Novel Anti-PCSK9 Antibodies |
| CN107840892A (zh) * | 2016-09-20 | 2018-03-27 | 上海药明生物技术有限公司 | 新型抗‑pcsk9抗体 |
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- 2020-02-10 CN CN202080095724.2A patent/CN115052899B/zh active Active
- 2020-02-10 WO PCT/CN2020/074624 patent/WO2021159235A1/zh active Application Filing
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- 2022-08-09 US US17/818,631 patent/US20230091895A1/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190233542A1 (en) * | 2016-09-20 | 2019-08-01 | WuXi Biologics Ireland Limited | Novel Anti-PCSK9 Antibodies |
| CN109897110A (zh) * | 2017-12-08 | 2019-06-18 | 深圳华大生命科学研究院 | 纳米抗体及其制备方法 |
Non-Patent Citations (2)
| Title |
|---|
| ELODIE WEIDER 等: "Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Single Domain Antibodies Are Potent Inhibitors of Low Density Lipoprotein Receptor Degradation" * |
| 张长江: "重组人前蛋白转化酶溶菌素9纳米抗体制备" * |
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| Publication number | Publication date |
|---|---|
| US20230091895A1 (en) | 2023-03-23 |
| CN115052899B (zh) | 2024-04-19 |
| WO2021159235A1 (zh) | 2021-08-19 |
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