CN115038701A - Jak抑制剂的晶型及其应用 - Google Patents

Jak抑制剂的晶型及其应用 Download PDF

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Publication number
CN115038701A
CN115038701A CN202180010731.2A CN202180010731A CN115038701A CN 115038701 A CN115038701 A CN 115038701A CN 202180010731 A CN202180010731 A CN 202180010731A CN 115038701 A CN115038701 A CN 115038701A
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degrees
compound
angles
ray powder
formula
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CN115038701B (zh
Inventor
毛魏魏
钱文远
韦昌青
方亮
穆利伟
陈曙辉
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Zhuhai United Laboratories Co Ltd
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Zhuhai United Laboratories Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

一种作为JAK抑制剂的晶型，以及在制备治疗JAK1或/和TYK2相关疾病的药物中的应用。

Description

PCT国内申请，说明书已公开。

Claims (26)

  1. PCT国内申请，权利要求书已公开。
CN202180010731.2A 2020-02-21 2021-02-22 Jak抑制剂的晶型及其应用 Active CN115038701B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2020101105307 2020-02-21
CN202010110530 2020-02-21
PCT/CN2021/077228 WO2021164786A1 (zh) 2020-02-21 2021-02-22 Jak抑制剂的晶型及其应用

Publications (2)

Publication Number Publication Date
CN115038701A true CN115038701A (zh) 2022-09-09
CN115038701B CN115038701B (zh) 2023-06-16

Family

ID=77391871

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180010731.2A Active CN115038701B (zh) 2020-02-21 2021-02-22 Jak抑制剂的晶型及其应用

Country Status (8)

Country Link
US (1) US20230091250A1 (zh)
EP (1) EP4108664A4 (zh)
JP (1) JP2023514291A (zh)
KR (1) KR20220157398A (zh)
CN (1) CN115038701B (zh)
AU (1) AU2021222686B2 (zh)
CA (1) CA3166743A1 (zh)
WO (1) WO2021164786A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240033255A1 (en) * 2021-01-29 2024-02-01 Zhuhai United Laboratories Co., Ltd. Oral preparation containing jak inhibitor or salt thereof or crystal form thereof, preparation method therefor, and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102105471A (zh) * 2008-07-25 2011-06-22 加拉帕戈斯股份有限公司 用于治疗变性和炎性疾病的新化合物
WO2018019223A1 (zh) * 2016-07-26 2018-02-01 张文燕 作为选择性jak抑制剂化合物，该化合物的盐类及其治疗用途
CN108341814A (zh) * 2017-01-23 2018-07-31 上海翔锦生物科技有限公司 Jak激酶抑制剂及其应用
CN110088105A (zh) * 2016-12-16 2019-08-02 詹森药业有限公司 Jak家族激酶的小分子抑制剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090220688A1 (en) 2005-07-27 2009-09-03 Buddy Tools, Llc Drywall tape and joint compound dispenser
WO2010010187A1 (en) * 2008-07-25 2010-01-28 Galapagos Nv Novel compounds useful for the treatment of degenerative and inflammatory diseases
AU2019326647B2 (en) * 2018-08-23 2022-02-10 Zhuhai United Laboratories Co., Ltd. (1,2,4)triazolo(1,5-a)pyridine compound as JAK inhibitor and application thereof
KR20220127900A (ko) * 2020-02-13 2022-09-20 주하이 유나이티드 라보라토리즈 컴퍼니 리미티드 Jak 키나아제 관련 질병의 치료를 위한 약물의 제조에 있어서 jak 억제제의 용도
US20240033255A1 (en) * 2021-01-29 2024-02-01 Zhuhai United Laboratories Co., Ltd. Oral preparation containing jak inhibitor or salt thereof or crystal form thereof, preparation method therefor, and application thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102105471A (zh) * 2008-07-25 2011-06-22 加拉帕戈斯股份有限公司 用于治疗变性和炎性疾病的新化合物
WO2018019223A1 (zh) * 2016-07-26 2018-02-01 张文燕 作为选择性jak抑制剂化合物，该化合物的盐类及其治疗用途
CN110088105A (zh) * 2016-12-16 2019-08-02 詹森药业有限公司 Jak家族激酶的小分子抑制剂
CN108341814A (zh) * 2017-01-23 2018-07-31 上海翔锦生物科技有限公司 Jak激酶抑制剂及其应用

Also Published As

Publication number Publication date
CA3166743A1 (en) 2021-08-26
KR20220157398A (ko) 2022-11-29
EP4108664A1 (en) 2022-12-28
WO2021164786A1 (zh) 2021-08-26
CN115038701B (zh) 2023-06-16
AU2021222686B2 (en) 2023-06-29
US20230091250A1 (en) 2023-03-23
EP4108664A4 (en) 2024-03-06
AU2021222686A1 (en) 2022-09-01
JP2023514291A (ja) 2023-04-05

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