CN114984462B - Cerenkov light dose monitoring method and device based on multichannel imaging - Google Patents
Cerenkov light dose monitoring method and device based on multichannel imaging Download PDFInfo
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- 238000003384 imaging method Methods 0.000 title claims abstract description 28
- 238000000034 method Methods 0.000 title abstract description 10
- 238000012544 monitoring process Methods 0.000 title abstract description 9
- 230000003287 optical effect Effects 0.000 claims description 7
- 238000012806 monitoring device Methods 0.000 claims description 6
- 230000035945 sensitivity Effects 0.000 claims description 4
- 238000012937 correction Methods 0.000 claims description 3
- 238000001514 detection method Methods 0.000 claims description 3
- 239000003623 enhancer Substances 0.000 claims description 3
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- 238000009499 grossing Methods 0.000 claims description 3
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- 230000009466 transformation Effects 0.000 claims description 3
- 230000008054 signal transmission Effects 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 2
- 230000000007 visual effect Effects 0.000 abstract description 2
- 230000001360 synchronised effect Effects 0.000 abstract 1
- 230000001960 triggered effect Effects 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 230000005466 cherenkov radiation Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- 238000006213 oxygenation reaction Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000004456 color vision Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000004980 dosimetry Methods 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 230000036541 health Effects 0.000 description 1
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- 230000003595 spectral effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1064—Monitoring, verifying, controlling systems and methods for adjusting radiation treatment in response to monitoring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1071—Monitoring, verifying, controlling systems and methods for verifying the dose delivered by the treatment plan
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Abstract
The invention provides a cerenkov light dose monitoring method and device based on multichannel imaging. Wherein the device includes: a multi-channel camera beam splitter assembly that splits the cerenkov light, the beam splitter assembly consisting of an RGB dichroic beam splitter and a bandpass filter, allows cerenkov light signals incident from the zoom lens to be redirected to the appropriate camera channel according to wavelength. And three independent ibcd modules packaged in a three-tube color camera assembly, the red, green, and blue channels being equipped with red, green, and blue sensitive ibcd modules, respectively. The camera is remotely triggered by stray X-rays, synchronized with the linac pulses and gated. The multi-channel processed image is finally combined into an RGB color image. The invention has the characteristics of visual imaging, large image information quantity, high positioning precision and the like, and can effectively improve the dose monitoring effect in radiotherapy.
Description
Technical Field
The invention relates to the field of radiotherapy and radiation imaging, in particular to a cerenkov light dose monitoring method and device based on multichannel imaging.
Background
Cancer has become the first killer threatening human life and health, and radiation therapy is one of the main means for treating malignant tumors, and has increasingly prominent roles and roles in tumor therapy. Photon therapy is the most mature radiation therapy technology at present, but is limited by the mechanical characteristics of radiotherapy equipment, the execution process of a treatment plan and the change of beam parameters, and the treatment beam can inevitably produce dose deposition on organs at the periphery of a target area, so that the radiotherapy effect is affected. Thus, further development of new real-time dose detection systems is needed.
Cerenkov radiation is a phenomenon of super-optical velocity movement of charged particles in a medium, where when the velocity of high velocity charged particles in the medium is greater than the traveling velocity of light in the medium, localized polarization is created in the direction of the path of movement and visible and near-infrared photons are released during return to equilibrium. Robertson et al for the first time applied Cerenkov radiation in the biomedical imaging field and proposed the concept of Cerenkov photoperiod imaging. The cerenkov light-emitting imaging has the characteristics of noninvasive, repeatable, real-time imaging and the like, and can be particularly used for monitoring the dosage in tissues in the radiotherapy process.
At present, a cerenkov light imaging dosimetry system mainly adopts a monochromatic enhanced camera, and living cerenkov light imaging in other wave bands is hardly paid attention to due to red light and near infrared weighted emission of tissues. However, changes in blood content and oxygenation within tissue have a large impact on the light emission, and the spectral changes associated therewith are believed to be diagnostic. Although cerenkov imaging systems have existed for many years, the advantages of multi-wavelength imaging in the context of radiation therapy have not been explored in depth. Therefore, developing a cerenkov light dose detection method and device based on multichannel imaging is a key technical problem to be solved.
Disclosure of Invention
In order to solve the technical problems, the invention aims to provide a cerenkov light dose monitoring method and device based on multichannel imaging, which have the characteristics of visual imaging and high positioning accuracy.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
a cerenkov light dose monitoring device based on multichannel imaging, comprising: a multi-channel camera beam splitter assembly for splitting cerenkov light, the beam splitter assembly comprising an RGB dichroic beam splitter (2) and a bandpass filter, allows cerenkov light signals incident from a zoom lens (1) to be redirected to appropriate camera channels according to wavelength, and three independent iCCD modules packaged in a three-tube color camera assembly, the red, green and blue channels being provided with red, green and blue sensitive iCCD modules, respectively, to spatially register three channel images and fuse the three channel images to obtain a color cerenkov light image.
The lens is a 10-100 mm f/1.6 zoom lens (1).
The beam splitter device comprises two dichroic beam splitters (2) which respectively separate blue wave bands and red wave bands from the Cerenkov optical signals, and the blue wave bands and the red wave bands and the filtered green wave bands are respectively transmitted to the iCCD module through band-pass filters.
The iCCD module consists of red, green and blue sensitivity enhancers (3, 4, 5) and a CCD module (6).
The image synthesis is to generate an RGB color image by registering and correcting a plurality of gray images obtained by multiple channels.
A cerenkov light dose monitoring method based on multichannel imaging comprises the following steps:
the multichannel camera was mounted on a tripod in a treatment room to acquire images, which were obtained in a 16-bit raw format using C-Dose research software. The FPGA of each camera is respectively subjected to time domain and space domain median filtering by adopting 5 frames and 5 multiplied by 5 pixel motion windows, so that additional denoising or smoothing in post-processing is eliminated;
a 120 frame dark field image stack is acquired and the average dark field frame number is calculated. For a given acquired dataset, each of the three image stacks takes a frame average and subtracts each average dark field frame;
performing two-dimensional polynomial transformation on green, red and blue images by using checkerboard-based geometric correction to spatially align three channels, thereby obtaining a three-channel image;
color cerenkov light images are obtained by combining the RGB three color channels.
The beneficial effects of the invention include:
(1) In the image obtained by imaging through the multichannel camera, various tissue characteristics not only show different intensities, but also have unique spectrum characteristics;
(2) The sensitivity of the images obtained through the imaging of the multichannel camera to the body surface features is beneficial to more accurately tracking the daily body position of a patient, and the acquisition of biological information such as blood volume and oxygenation saturation can help a clinician to grasp the physiological response of the patient to treatment such as the development of erythema;
(3) The technology of the invention presents the natural superposition of the cerenkov light and the background signal through simultaneous collection and accumulation, and more truly visualizes the interaction of radiation and tissues;
(4) The invention enables a useful image to be obtained without background subtraction, since the contrast between the cerenkov signal and the background is achieved by color perception.
Drawings
Fig. 1 is a schematic diagram of a multi-channel camera according to the present invention.
Fig. 2 is a flowchart of a multi-channel imaging method according to the present invention.
Detailed Description
The present invention will be described in further detail with reference to examples.
As shown in fig. 1: a cerenkov light dose monitoring device based on multichannel imaging, comprising: a multi-channel camera beam splitter assembly for splitting cerenkov light, the beam splitter assembly comprising an RGB dichroic beam splitter (2) and a bandpass filter, allows cerenkov light signals incident from a zoom lens (1) to be redirected to appropriate camera channels according to wavelength, and three independent iCCD modules packaged in a three-tube color camera assembly, the red, green and blue channels being provided with red, green and blue sensitive iCCD modules, respectively, to spatially register three channel images and fuse the three channel images to obtain a color cerenkov light image.
The lens is a 10-100 mm f/1.6 zoom lens (1).
The beam splitter device comprises two dichroic beam splitters (2) which respectively separate blue wave bands and red wave bands from the Cerenkov optical signals, and the blue wave bands and the red wave bands and the filtered green wave bands are respectively transmitted to the iCCD module through band-pass filters.
The iCCD module consists of red, green and blue sensitivity enhancers (3, 4, 5) and a CCD module (6).
The image synthesis is to generate an RGB color image by registering and correcting a plurality of gray images obtained by multiple channels.
As shown in fig. 2: a method and a device for monitoring the optical dose of Cerenkov based on multichannel imaging are used, and the method comprises the following steps:
the patient is treated in a right supine position so that the multichannel cerenkov light camera is mounted on a tripod against the left wall of the treatment room to prevent the head occlusion caused by the left anterior oblique and right posterior oblique line areas. The patient received 6MV X-ray treatment, and the illumination condition of the treatment room was the same as the standard illumination level.
The multichannel camera is mounted on a tripod of a treatment room to acquire an image, and a 16-bit original-format cerenkov light image is acquired. The FPGA of each camera is respectively subjected to time domain and space domain median filtering by adopting 5 frames and 5 multiplied by 5 pixel motion windows, so that additional denoising or smoothing in post-processing is eliminated;
a 120 frame dark field image stack was acquired and the average dark field frame number was calculated. For a given acquired dataset, each of the three image stacks is a frame average and subtracted from each average dark field frame;
performing two-dimensional polynomial transformation on the green and blue images by using checkerboard-based geometric correction, and spatially aligning three channels to obtain a three-channel image;
color cerenkov light images are obtained by combining the RGB three color channels.
Claims (4)
1. A cerenkov light dose monitoring device based on multichannel imaging, comprising: a multi-channel camera beam splitter assembly for splitting cerenkov light, the beam splitter assembly comprising an RGB dichroic beam splitter (2) and a bandpass filter, allowing cerenkov light signals incident from a zoom lens (1) to be redirected to appropriate camera channels according to wavelength, and three independent iCCD modules packaged in a three-tube color camera assembly, the red, green and blue channels being respectively equipped with red, green and blue sensitive iCCD modules, the three-channel images being spatially registered and fused to obtain color cerenkov light images; the operation steps comprise:
the multichannel cameras are arranged on a tripod of a treatment room to acquire images, a three-channel Cerenkov light data set and a 120-frame dark field image stack are acquired, and time domain and space domain median filtering is adopted on an FPGA of each camera, so that additional denoising or smoothing in post-processing is avoided;
the cerenkov optical signals detected by the optical detection equipment in real time are wirelessly transmitted to the processor through the signal transmission system;
calculating average frames of dark field image stacks in a processor, calculating respective average frames from the red, green and blue three-channel image stacks, and subtracting corresponding average dark field frames;
performing two-dimensional polynomial transformation on the three-channel image by using geometric correction based on a checkerboard, and spatially aligning three channels to obtain the three-channel image;
color cerenkov light images are obtained by combining the RGB three color channels.
2. The cerenkov light dose monitoring device based on multi-channel imaging of claim 1, wherein the zoom lens is a 10-100 mm f/1.6 zoom lens (1).
3. A cerenkov optical dose monitoring device based on multi-channel imaging as claimed in claim 1, wherein the beam splitter assembly comprises two dichroic beam splitters (2) to separate the blue and red bands from the cerenkov optical signal respectively.
4. The cerenkov light dose monitoring device based on multi-channel imaging according to claim 1, wherein the ibcd module consists of red, green and blue sensitivity enhancers (3, 4, 5) and a CCD module (6).
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