CN107088266A - Photodynamic therapy system with visualization function - Google Patents
Photodynamic therapy system with visualization function Download PDFInfo
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- CN107088266A CN107088266A CN201710219703.7A CN201710219703A CN107088266A CN 107088266 A CN107088266 A CN 107088266A CN 201710219703 A CN201710219703 A CN 201710219703A CN 107088266 A CN107088266 A CN 107088266A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/067—Radiation therapy using light using laser light
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/063—Radiation therapy using light comprising light transmitting means, e.g. optical fibres
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
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Abstract
The present invention is applied to optical dynamic therapy technical field, there is provided a kind of photodynamic therapy system with visualization function, exposure and readout sequence signal that the electronic CCD or CMOS optical systems are exported are loaded into the chopper of phototiming module by the triggering port, so as to control the chopper to separate light path or momentary connection light path in electronic CCD or CMOS optical system exposure stages, and light path is continuously turned in the reading stage, so as to produce lock-out pulse treatment laser；If electronic CCD or CMOS optical systems are in exposure stage because light path is separated without receiving reflection or being scattered back the treatment laser come, organization chart picture is visual during optical dynamic therapy can be achieved；If receiving reflection in exposure stage or being scattered back the transient therapy laser come, also real-time display treatment hot spot border in organization chart picture, and organization chart picture can be not only provided in real time for doctor, so as to realize that image fidelity is visual during optical dynamic therapy.
Description
Technical field
The invention belongs to optical dynamic therapy technical field, more particularly to a kind of optical dynamic therapy system with visualization function
System.
Background technology
China is one of global cancer district occurred frequently.The World Health Organization delivers on the 3rd in this year 2 month《Global cancer report
Accuse》, study and claim Cancer in China new cases in 2012 to occupy first of the whole world, nearly 50% new cases occur in China.Moreover, oesophagus
Cancer, stomach cancer, liver cancer and the big malignant tumour of lung cancer 4 occupy first place in the world in the new cases and death toll of China.With the cancer of the esophagus
Exemplified by, the data that the World Health Organization announces is shown, China increases the cancer of the esophagus about 260,000 newly every year, and the incidence of disease is 16.7/10 ten thousand
People, the death rate is 13.4/10 ten thousand people, no matter falls ill or the death toll Jun Zhan worlds are more than half.
It is middle and advanced stage during more than 80% Finding case due to there is no effective early stage non-invasive diagnosis method.If taking hand
Art is treated, and because operation need to open chest, can there is larger wound to patient's body；If chemicotherapy treatment method is taken, due to putting
Treat whole body toxic side effect strong, body normal immunological function, poor life quality after patient's treatment can be reduced, and long term survival rate is still not
It is preferable.Optical dynamic therapy (Photodynamic therapy, PDT) is that one kind meets 21 century oncotherapy developing direction (target
To, part, individuation) new technology, there is targeting, local treatment, personalized treatment, with operation, chemotherapy, radiotherapy
Four kinds of main methods of oncotherapy are listed as, the treatment of the diseases such as the tumour of a variety of Microendoscopics has been successfully applied to.
But, optical dynamic therapy LASER Light Source power output is higher, can make endoscope CCD (Charge-coupled
Device, charge coupled cell) or CMOS (Complementary Metal Oxide Semiconductor, complementary metal oxygen
Compound semiconductor) detector saturation, display screen is in that brilliant white is a piece of.Doctor is in blind regarding state in whole therapeutic process, it is impossible to
Organization chart picture is intuitively seen from display screen, this is the common problem that PDT faces under current all fujinon electronic video endoscopes.It is blind to regard lower carry out
Optical dynamic therapy operation difficulty is big, technical requirements are high, greatly reduces the accuracy and security for the treatment of, adds operation wind
Danger；Also increase research optical dynamic therapy dose-effect relationship, the difficulty of therapeutic dose optimization, limit related new photosensitive drug,
The development in the basic research fields such as dosage real-time monitoring and regulating technology, seriously hinders Microendoscopic optical dynamic therapy basic research
Expansion and clinical practice promote.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of photodynamic therapy system with visualization function, purport
Solving, because photodynamic therapy light source power output is higher, to cause display screen a piece of in brilliant white, so as to cause doctor whole
Organization chart picture can not be intuitively seen in therapeutic process, the accuracy and security for the treatment of is greatly reduced, adds operation risk
The problem of.
The invention provides a kind of photodynamic therapy system with visualization function, the photodynamic therapy system bag
Include：Video image dendoscope system, optical dynamic therapy laser system and phototiming module；
The video image dendoscope system includes video image dendoscope and scope monitor, and the video image dendoscope includes soft scope end
Portion, the front end of the soft scope end includes electronic CCD or CMOS optical systems；
The optical dynamic therapy laser system includes optical dynamic therapy LASER Light Source and output optical fibre, the phototiming module
Including collimation transmitting light path, chopper, collimation receiving light path and triggering port, the triggering port is connected with the chopper,
And be connected with the video image dendoscope, for the exposure for exporting the electronic CCD or CMOS optical systems and readout sequence signal
It is transferred to the chopper；The collimation receiving light path is used for the treatment laser for exporting the optical dynamic therapy LASER Light Source
The chopper is defeated by, and the chopper is used to the treatment laser is synchronized according to the exposure and readout sequence signal
Chopping modulation, separates light path or momentary connection light path in electronic CCD or CMOS optical system exposure stages, continues in the stage of reading
Light path is connected, and obtained lock-out pulse is treated into Laser Transmission to the collimation and launches light path, and it is defeated from the output optical fibre
Go out；The output optical fibre is used to via the video image dendoscope export lock-out pulse treatment laser to human lesion tissue,
So that the electronic CCD or CMOS optical systems are in exposure stage, the output optical fibre does not export treatment laser or output wink
When treat laser, and treatment laser is persistently exported at the stage of reading, to obtain the first tissue view data or minor microstructure
View data；
The scope monitor is used to show the first tissue image formed by the first tissue view data, or is used for
The minor microstructure image formed by the minor microstructure view data is shown, the first tissue image is without treatment hot spot
The organization chart picture on border, the minor microstructure image is the organization chart picture with treatment hot spot border.
Further, the collimation receiving light path includes input, the first optical fiber and the first lens being sequentially connected, described
Input is connected with optical dynamic therapy LASER Light Source, and first optical fiber swashs for transmitting the treatment inputted by the input
Light；First lens are for by the treatment laser alignment is into directional light and inputs to the chopper.
Further, the collimation transmitting light path includes the second lens, the second optical fiber and the connector being sequentially connected, described
Connector is connected with the output optical fibre, and second lens are used for the pulse therapy laser coupled for exporting the chopper simultaneously
Output inputs the output optical fibre to second optical fiber via second optical fiber and the connector.
Further, the video image dendoscope also includes：Operation handle and instrument channel, the front end of the soft scope end
Also include instrument channel to export；
The output optical fibre is penetrated from the entrance of the instrument channel and passed from instrument channel outlet, so that described
Lock-out pulse treatment laser is exported to human lesion tissue via the video image dendoscope.
Further, the front end of the soft scope end also includes illumination light exit, and the video image dendoscope system is also wrapped
Cold light source host is included, the video image dendoscope also includes data connector；
The cold light source host is connected by the data connector with the video image dendoscope, for providing lighting source, with
Just from the illumination light exit output illumination light.
Further, the video image dendoscope system also includes shooting main frame, and the shooting main frame passes through the data connector
It is connected with the video image dendoscope, the shooting main frame is also connected with the scope monitor, for according in the video image dendoscope
Electronic CCD or obtained the first tissue figure of the first tissue view data formation without treatment hot spot border of CMOS optical systems
Picture, or formed for the minor microstructure view data that the electronic CCD in the video image dendoscope or CMOS optical systems are obtained
Minor microstructure image with treatment hot spot border, and the first tissue image or minor microstructure image are sent in described
Mirror monitor is shown.
Further, time for exposure and light of the CCD or CMOS of the electronic CCD or CMOS optical systems in exposure stage
The overlapping time △ t of the optical circuit time of dynamic therapy laser system meets △ t=t0-t2, t0For the electronic CCD or
The CCD or CMOS of CMOS optical systems are in the time for exposure of exposure stage, t2For the light path of the optical dynamic therapy laser system
The cut-off time；
Wherein, as △ t≤0, expression separates light path, the output in electronic CCD or CMOS optical system exposure stages
Optical fiber does not export treatment laser in exposure stage；
As 0 ＜ △ t≤0.5t0When, represent in electronic CCD or last △ t winks time in CMOS optical system exposure stages
When connect light path, the output optical fibre exports transient therapy laser in exposure stage.
Further, the output power range of the treatment laser of the optical dynamic therapy LASER Light Source output is 0W-3W；Institute
Output optical fibre is stated for end face output optical fibre or side output optical fibre, the light extraction zone length of the side output optical fibre is 10mm-
200mm。
Further, the diameter of the electronic CCD or CMOS optical systems is not more than 5.0mm, the core of the CCD or CMOS
Chip size≤1/4 ", the valid pixel of the CCD or CMOS is not less than 480,000, and the angle of view of the CCD or CMOS is not small
In 100 °.
Further, the material of the soft scope end is flexible material, its bendable front end；The instrument channel
Diameter is not more than 5mm.
Compared with prior art, beneficial effect is the present invention：The invention provides a kind of light with visualization function
Dynamic therapy system, the system introduces optical synchronization technology, the exposure and reading that the electronic CCD or CMOS optical systems are exported
Go out clock signal and be loaded into the chopper of phototiming module by triggering port, thus control the chopper in electronic CCD or
The CMOS optical system exposure stages separate light path or momentary connection light path, and are continuously turned on light path in the reading stage, so as to produce
Lock-out pulse treats laser；If electronic CCD or CMOS optical systems are in exposure stage because light path is separated without receiving reflection
Or being scattered back the treatment laser come, then organization chart picture is visual during optical dynamic therapy can be achieved；If being received in exposure stage
The transient therapy laser come is reflected or is scattered back, then the image information that electronic CCD or CMOS optical systems are obtained both has treatment
Laser intelligence, but it is unsaturated, also real-time display in organization chart picture, and organization chart picture so not only can be in real time provided for doctor and controlled
Hot spot border is treated, so as to realize that image fidelity is visual during optical dynamic therapy, and enables the clinician to intuitively see treatment hot spot position
Put the position relationship with pathological tissues, it is to avoid the blind operation of doctor by rule of thumb, improve therapeutic effect, and avoid excessive radiation, photograph
The problems such as penetrating not enough or inaccurate irradiation.
Brief description of the drawings
Fig. 1 is a kind of structural representation of photodynamic therapy system with visualization function provided in an embodiment of the present invention
Figure；
Fig. 2 is the schematic diagram of phototiming module provided in an embodiment of the present invention；
Fig. 3 is that the annexation of optical dynamic therapy laser system provided in an embodiment of the present invention and phototiming module is illustrated
Figure；
Fig. 4 is the structural representation of video image dendoscope provided in an embodiment of the present invention；
Fig. 5 is the structural representation of the front end of the soft scope end of video image dendoscope provided in an embodiment of the present invention；
Fig. 6 a be the CCD or CMOS chip of electronic CCD provided in an embodiment of the present invention or CMOS optical systems exposure and
Readout sequence signal；
Fig. 6 b are choppers provided in an embodiment of the present invention to treating the blocking of laser output light path and connecting clock signal
Schematic diagram；
Fig. 6 c are that treatment laser output light path provided in an embodiment of the present invention has a light output and unglazed output timing signal
Schematic diagram；
Fig. 7 is the schematic diagram provided in an embodiment of the present invention for stomach detect treatment using video image dendoscope；
Fig. 8 a be the CCD or CMOS chip of electronic CCD provided in an embodiment of the present invention or CMOS optical systems exposure and
Readout sequence signal；
Fig. 8 b are choppers provided in an embodiment of the present invention to treating the blocking of laser output light path and connecting clock signal
Schematic diagram；
Fig. 8 c are that treatment laser output light path provided in an embodiment of the present invention has a light output and unglazed output timing signal
Schematic diagram；
Fig. 9 a are that the video image dendoscope of traditional photodynamic therapy system provided in an embodiment of the present invention carries out treatment laser irradiation
Preceding image；
Fig. 9 b are that the video image dendoscope of traditional photodynamic therapy system provided in an embodiment of the present invention carries out treatment laser irradiation
Image；
Fig. 9 c are that the video image dendoscope of photodynamic therapy system provided in an embodiment of the present invention carries out the figure for the treatment of laser irradiation
Picture.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, it is right below in conjunction with drawings and Examples
The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and
It is not used in the restriction present invention.
The realization principle of the technical scheme in the embodiment of the present invention is first introduced below, it is as follows：
Exposure and reading electronic CCD or CMOS optical systems include exposure stage and reading stage, wherein, exposure stage is
Refer to the exposure image stage, and it is due to that the power height for treating laser in exposure stage causes that a piece of situation of brilliant white, which occurs, in display screen
Detector saturation in electronic CCD or CMOS optical systems.In order to avoid there is the situation that display screen brilliant white is a piece of, it may be considered that
Treatment laser is not exported in the exposure stage of electronic CCD or CMOS optical systems, and treats laser to human body in order to utilize
Pathological tissues are treated, then can read the stage output treatment laser, therefore, it can consider by treat laser output with
The exposure stage and the stage holding of reading of electronic CCD or CMOS optical systems are synchronously.Further, since an exposure stage and one
The cycle in reading stage is very short, is not in the problem of organization chart picture flashes, this hair for the human eye viewing of doctor
Bright technical scheme is, by above-mentioned principle, to increase phototiming module in photodynamic therapy system so that can not only realize
Utilize the purpose for treating laser therapy, additionally it is possible to realize the visualization of organization chart picture.
In addition, doctor determines treatment hot spot border from organization chart picture for convenience, technical solution of the present invention can also be examined
The exposure stage considered in electronic CCD or CMOS optical systems exports transient therapy laser, and treatment is persistently exported in the reading stage and is swashed
Light；Due to being output transient therapy laser in exposure stage, the detector in electronic CCD or CMOS optical systems will not be caused
Saturation, so being not in a piece of situation of display screen brilliant white；It can not only so realize using the purpose for treating laser therapy,
It can also realize in organization chart picture comprising treatment hot spot border.
Lower mask body introduces this photodynamic therapy system with visualization function, as Figure 1-3, the smooth power
Treatment system includes：Optical dynamic therapy laser system, phototiming module and video image dendoscope system；
The optical dynamic therapy laser system includes optical dynamic therapy LASER Light Source 1 and output optical fibre 2, the phototiming mould
Block includes collimation transmitting light path, chopper 304, collimation receiving light path and triggering port 305；The triggering port 305 with it is described
Chopper 304 is connected, and the exposure and readout sequence signal for electronic CCD or CMOS optical systems 4013 to be exported are transferred to and cut
Ripple device 304；Collimation receiving light path is used for the treatment Laser Transmission for exporting optical dynamic therapy LASER Light Source 1 to chopper 304, cuts
Ripple device 304 is used to synchronize chopping modulation to treatment laser according to exposure and readout sequence signal, and by obtained synchronous arteries and veins
Punching treatment Laser Transmission is exported to collimation transmitting light path from the output optical fibre 2.
Further, input 301, the first optical fiber 302 and first that the collimation receiving light path includes being sequentially connected are saturating
Mirror 303, input 301 is connected with optical dynamic therapy LASER Light Source 1, and the first optical fiber 302 is used to transmit what is inputted by input 301
Treat laser；First lens 303 are used to that laser alignment will to be treated into directional light and inputted to chopper 304.
Further, the collimation transmitting light path includes the second lens 306, the second optical fiber 307 and connection being sequentially connected
Device 308, the lens 306 of connector 308 second are used for the pulse therapy laser coupled for exporting chopper 304 and exported to the second light
Fibre 307, the output optical fibre 2 is inputted via the second optical fiber 307 and connector 308, wherein, the connector 308 passes through optical fiber
Connection end 201 is connected with the output optical fibre 2.
Specifically, the treatment laser output power scope that the optical dynamic therapy LASER Light Source 1 is exported is 0W-3W；It is described
Output optical fibre 2 is end face output optical fibre or side output optical fibre, and the light extraction zone length of the side output optical fibre is 10mm-
200mm。
The video image dendoscope system includes video image dendoscope 4, cold light source host 5, shooting main frame 6 and scope monitor 7；It is described
Video image dendoscope 4 is applied to 532nm, and the treatment laser of a variety of wave bands such as 630nm, the video image dendoscope 4 includes soft scope end
401st, instrument channel 402, operation handle 403 and data connector 404, it is specific as shown in Figure 4；As shown in figure 5, the soft scope
The front end of end 401 includes illumination light exit 4011 and instrument channel outlet 4012, is also equipped with electronic CCD or CMOS optical systems
System 4013；The output optical fibre 2 is penetrated by the instrument channel 402 and passed from instrument channel outlet 4012, for inciting somebody to action
Lock-out pulse treatment laser is exported to human lesion tissue via the video image dendoscope.
Specifically, the diameter of instrument channel 402 is not more than 5mm, and the material of the soft scope end 401 is soft material
Material, its bendable front end；It is that the front end of the soft scope end 401 is imported into human body when carrying out optical dynamic therapy, it is synchronous
Pulse therapy laser is exported from the output optical fibre 2.
Specifically, the cold light source host 5 is connected by the data connector 404 with the video image dendoscope 4, for providing
Lighting source；More specifically, the lighting source that the cold light source host 5 is provided inputs institute from illumination light entrance (not shown)
State after video image dendoscope 4, export, pass through between the illumination light entrance and illumination light exit 4011 from the illumination light exit 4011
Optical fiber transmits illumination light.
Specifically, video image dendoscope 4 provided in an embodiment of the present invention has two illumination light exits 4011.
Further, the electronic CCD or CMOS optical systems 4013 in the video image dendoscope by data connector with it is described
Triggering port connection in phototiming module, for the exposure and reading for exporting the electronic CCD or CMOS optical systems 4013
Go out clock signal and be loaded into chopper by triggering port, so as to control the chopper in electronic CCD or CMOS optical systems
4013 exposure stages separate light path or momentary connection light path, are continuously turned on light path in the reading stage, are controlled so as to produce lock-out pulse
Treat laser.
Further, if chopper 304 is being read in electronic CCD or the exposure stage of CMOS optical systems 4013 cut-off light path
Going out the stage is continuously turned on light path, then the electronic CCD or CMOS optical systems 4013 receive reflection in exposure stage or be scattered back
The illumination light come, and the first tissue view data is recorded, in the stage of reading, there are treatment laser, illumination light output to human lesion
Tissue, yet with the process in the reading stage being view data reading, is not directed to Imagery Data Recording, even if treatment swashs
The power of light is big, does not also result in electronic CCD or electronic CCD or cmos detector saturation in CMOS optical systems 4013, and
In the stage of reading, the organization chart picture data that exposure stage is recorded are sent to shooting main frame formation organization chart picture, not had
There is the first tissue image on treatment hot spot border；By above-mentioned exposure stage and read the stage and alternate, utilize treatment
On the basis of laser is treated, it is possible to achieve the visualization of organization chart picture.
If chopper 304 is in electronic CCD or the exposure stage momentary connection light path of CMOS optical systems 4013, in the stage of reading
Light path is continuously turned on, then the electronic CCD or CMOS optical systems 4013 receive reflection in exposure stage or be scattered back the photograph come
Mingguang City and transient therapy laser, and minor microstructure view data is recorded, swash yet with the transient therapy received in exposure stage
Light is very low in the mean power of whole exposure stage, e insufficient to cause the electronics in electronic CCD or CMOS optical systems 4013
CCD or cmos detector saturation；In the stage of reading, there are treatment laser, illumination light output to read the stage to human lesion tissue
It is the process that view data is read, is not directed to Imagery Data Recording, even if the power for the treatment of laser is big, does not also result in electricity
Electronic CCD or cmos detector saturation in sub- CCD or CMOS optical systems 4013, and in the stage of reading, exposure stage is remembered
The organization chart picture data of record are sent to shooting main frame formation organization chart picture, and the transient therapy laser reality received according to exposure stage
When extract treatment hot spot border, to obtain the minor microstructure image with treatment hot spot border.Pass through above-mentioned exposure stage and reading
Go out alternateing for stage, using treating on the basis of laser treated, can not only realize the visualization of organization chart picture,
And the organization chart picture with treatment hot spot border can be obtained.
The video image dendoscope system also includes scope monitor 7, and the scope monitor 7 is used to show without treatment hot spot side
The first tissue image on boundary, or for showing the minor microstructure image with treatment hot spot border.
Specifically, the diameter of electronic CCD or CMOS optical systems 4013 is not more than 5mm, the chip chi of the CCD or CMOS
Very little≤1/4 ", the valid pixel of the CCD or CMOS are not less than 480,000, and the angle of view of the CCD or CMOS are not less than
100°。
Specifically, it is described shooting main frame 6 be connected with the scope monitor 7, and by the data connector 404 with it is described
Video image dendoscope 4 is connected；More specifically, the shooting main frame 6 passes through the data connector 404 and the electronics of the video image dendoscope 4
CCD or CMOS optical systems 4013 are connected；The shooting main frame 6 is used for according to the electronic CCD or CMOS optical systems 4013
The first tissue image of the first tissue view data generation without treatment hot spot border of acquisition, and by described without treatment hot spot border
The first tissue image be sent to the scope monitor 7；Or the shooting main frame 6 is used for according to the electronic CCD or CMOS
Minor microstructure image of the minor microstructure view data generation with treatment hot spot border that optical system 4013 is obtained, and will be described
Minor microstructure image with treatment hot spot border is sent to the scope monitor；The scope monitor 7 is used to show nothing
Treat the first tissue image on hot spot border or for showing the minor microstructure image with treatment hot spot border.
Further, in embodiments of the present invention, the photodynamic therapy system can also include mode selection switch, be used for
Switch non-optical dynamic therapy pattern and optical dynamic therapy pattern, wherein, non-optical dynamic therapy pattern refers to that not starting light power controls
The electronic CCD or CMOS optical systems 4013 treated in laser system and the work of phototiming module, video image dendoscope system receive reflection
Or be scattered back the illumination light come and be imaged, it is only capable of obtaining organization chart picture, and the organization chart picture does not treat hot spot border, leads to
Normal this kind of pattern is checked for doctor to human lesion tissue.Wherein, optical dynamic therapy pattern refers to that optical dynamic therapy swashs
Photosystem and the work of phototiming module, export to human lesion tissue and include pulse therapy laser and illumination light, and this
In the case of, and comprising two kinds of situations, on the premise of it can carry out laser therapy, show the first tissue figure without treatment hot spot border
The minor microstructure image of picture or display with treatment hot spot border.
The two kinds of situations existed under optical dynamic therapy pattern are described below：Display does not have the first for the treatment of hot spot border
The minor microstructure image of organization chart picture or display with treatment hot spot border.
The situation that the first tissue image without treatment hot spot border is shown under optical dynamic therapy pattern is first introduced below：This
In the case of kind, optical dynamic therapy LASER Light Source and output optical fibre are connected by phototiming module, provide same using phototiming module
The pulse therapy laser of step；Specifically, the treatment laser of the optical dynamic therapy LASER Light Source output is defeated by collimation receiving light path
Enter and be collimated into directional light, the runner of chopped device synchronizes chopping modulation, produce synchronous light pulse, then collimated transmitting light
Road enters output optical fibre, and treats laser from output optical fibre output lock-out pulse.Fig. 6 a show electronic CCD or CMOS light
The CCD or CMOS chip of system exposure and readout sequence signal, wherein, high level correspondence exposure stage, low level correspondence
Reading stage, the clock signal is loaded into phototiming module 3 by triggering port 305, controls the runner of chopper 304 synchronously to hinder
Disconnected or connection light path；Such as Fig. 6 b show chopper to treating the blocking of laser output light path and connecting clock signal, wherein, it is low
The light path of level correspondence chopper is blocked, the optical circuit of high level correspondence chopper, produces synchronism output light pulse；Such as Fig. 6 c
Show that treatment laser output light path has light output and unglazed output timing signal, wherein, high level is to that should have light output, low electricity
Flat correspondence is without light output.Output optical fibre 2 is penetrated by instrument channel 402 and passed from instrument channel outlet 4012, so that synchronous
Pulse therapy laser is exported to human lesion tissue via video image dendoscope 4.It is illustrated in figure 7 and stomach 8 is entered using video image dendoscope
The schematic diagram of row detection treatment, video image dendoscope uses electronic CCD or CMOS optical systems 4013, electronic CCD or CMOS optical systems
System is received reflects or is scattered back the illumination light come in exposure stage, and obtained in real time according to the illumination light in therapeutic process the
One organization chart picture data, scope monitor shows the first tissue image without treatment hot spot border.This CCD or CMOS chip expose
Light irradiates alternate mode of operation with treatment laser, can reach visual effect during optical dynamic therapy, and in the absence of filter
The colour cast problem that light technology is introduced, meanwhile, the technology is all suitable for for the treatment laser of any wavelength, unlike optical filtering technique, pin
Different treatment laser is needed to change the electronic CCD of different spectrum parameters or CMOS optical systems.
Introducing the display under optical dynamic therapy pattern again below has a case that the minor microstructure image for treating hot spot border：
In this case, as shown by figures 8 a-8 c, in order to during optical dynamic therapy organization chart picture it is visual on the basis of, it is further real
Now treatment laser facula border is visible, and the present invention proposes △ t parameter methods, △ t=t0-t2,t0It is electronic CCD or CMOS light
The CCD of system or the time for exposure of CMOS chip, t2It is the light path Xining of optical dynamic therapy laser system, △ t are to expose
With the overlapping time of optical circuit time between light time.Work as 0.5t0≥△t>When 0, represent to expose in electronic CCD or CMOS optical systems
The last △ t time momentary connections light path of photophase, the output optical fibre exports transient therapy laser in exposure stage；CCD or
The image information that CMOS chip is obtained both had included treatment laser intelligence, and unsaturated, by controlling △ t size, can control
The energy of the treatment laser recorded in each image, by treating the intensity distribution of laser, recognizes hot spot irradiation area, and utilize
Pseudo- colour display screen shows treatment laser facula boundary line, and can show the three-dimensional curve for the treatment of laser intensity simultaneously, for intuitively aobvious
Show the intensity distribution for the treatment of laser organizationally, be conducive to control to improve treatment laser dosage, improve curative effect.In addition, when △ t≤
When 0, represent to show the situation of the first tissue image without treatment hot spot border under optical dynamic therapy pattern.
As shown in figures 9 a-9 c, Fig. 9 a carry out treating prelaser for the video image dendoscope of traditional photodynamic therapy system
Image, Fig. 9 b are that the video image dendoscope of traditional photodynamic therapy system carries out the image for the treatment of laser irradiation, and Fig. 9 c carry for this patent
The chopper of confession is in the case of exposure stage momentary connection light path, and the video image dendoscope of photodynamic therapy system carries out treatment laser
The image of irradiation.
A kind of photodynamic therapy system with visualization function that the present invention is provided, if electronic CCD or CMOS optical systems
Unite when exposure stage separates without receiving reflection or being scattered back the treatment laser come because of light path, optical dynamic therapy can be achieved
During organization chart picture it is visual；If when exposure stage receives reflection or is scattered back the transient therapy laser come, electronic CCD
Or the image information that CMOS optical systems are obtained both had included treatment laser intelligence, but it is unsaturated, so not only can be real-time for doctor
There is provided and also show treatment hot spot border in organization chart picture, and organization chart picture in real time, so as to scheme during realizing optical dynamic therapy
As true to nature visual, and enable the clinician to intuitively see the position relationship for the treatment of facula position and pathological tissues, it is to avoid doctor is by rule of thumb
Blind operation, improve therapeutic effect, and avoid the problems such as excessive radiation, underexposure or irradiation inaccurate.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
Any modifications, equivalent substitutions and improvements made within refreshing and principle etc., should be included in the scope of the protection.
Claims (10)
1. a kind of photodynamic therapy system with visualization function, it is characterised in that the photodynamic therapy system includes：Electricity
Sub- endoscope system, optical dynamic therapy laser system and phototiming module；
The video image dendoscope system includes video image dendoscope and scope monitor, and the video image dendoscope includes soft scope end, institute
Stating the front end of soft scope end includes electronic CCD or CMOS optical systems；
The optical dynamic therapy laser system includes optical dynamic therapy LASER Light Source and output optical fibre, and the phototiming module includes
Collimation transmitting light path, chopper, collimation receiving light path and triggering port, the triggering port are connected with the chopper, and with
The video image dendoscope connection, for the exposure and readout sequence signal of the electronic CCD or the output of CMOS optical systems to be transmitted
To the chopper；The collimation receiving light path be used for the treatment Laser Transmission that exports the optical dynamic therapy LASER Light Source to
The chopper, the chopper is used to synchronize copped wave to the treatment laser according to the exposure and readout sequence signal
Modulation, separates light path or momentary connection light path in electronic CCD or CMOS optical system exposure stages, is continuously turned in the reading stage
Light path, and obtained lock-out pulse is treated into Laser Transmission to the collimation transmitting light path, and exported from the output optical fibre；Institute
Stating output optical fibre is used to via the video image dendoscope export lock-out pulse treatment laser to human lesion tissue, so that institute
Electronic CCD or CMOS optical systems are stated in exposure stage, the output optical fibre does not export treatment laser or output transient therapy
Laser, and treatment laser is persistently exported at the stage of reading, to obtain the first tissue view data or minor microstructure picture number
According to；
The scope monitor is used to show the first tissue image formed by the first tissue view data, or for showing
The minor microstructure image formed by the minor microstructure view data, the first tissue image is without treatment hot spot border
Organization chart picture, the minor microstructure image is the organization chart picture with treatment hot spot border.
2. photodynamic therapy system according to claim 1, it is characterised in that the collimation receiving light path includes connecting successively
Input, the first optical fiber and the first lens connect, the input is connected with optical dynamic therapy LASER Light Source, first optical fiber
For transmitting the treatment laser inputted by the input；First lens are used for the laser alignment for the treatment of into directional light
And input to the chopper.
3. photodynamic therapy system according to claim 1, it is characterised in that the collimation transmitting light path includes connecting successively
The second lens, the second optical fiber and the connector connect, the connector is connected with the output optical fibre, and second lens are used for will
The pulse therapy laser coupled of the chopper output is simultaneously exported to second optical fiber, via second optical fiber and the company
Connect device and input the output optical fibre.
4. photodynamic therapy system according to claim 1, it is characterised in that the video image dendoscope also includes：Manipulator
Handle and instrument channel, the front end of the soft scope end also include instrument channel and exported；
The output optical fibre is penetrated from the entrance of the instrument channel and passed from instrument channel outlet, so that the synchronization
Pulse therapy laser is exported to human lesion tissue via the video image dendoscope.
5. photodynamic therapy system according to claim 4, it is characterised in that also wrap the front end of the soft scope end
Illumination light exit is included, the video image dendoscope system also includes cold light source host, and the video image dendoscope also includes data connector；
The cold light source host is connected by the data connector with the video image dendoscope, for providing lighting source, so as to from
The illumination light exit output illumination light.
6. photodynamic therapy system according to claim 5, it is characterised in that the video image dendoscope system also includes shooting
Main frame, the shooting main frame is connected by the data connector with the video image dendoscope, it is described shooting main frame also with the scope
Monitor is connected, the first tissue picture number obtained for the electronic CCD in the video image dendoscope or CMOS optical systems
According to the first tissue image of the formation without treatment hot spot border, or for the electronic CCD in the video image dendoscope or CMOS light
Minor microstructure image of the minor microstructure view data formation with treatment hot spot border that system is obtained, and by described first group
Knit image or minor microstructure image is sent to the scope monitor and shown.
7. photodynamic therapy system as claimed in claim 1, it is characterised in that the electronic CCD or CMOS optical systems
Overlapping time △ ts of the CCD or CMOS in the time for exposure and the optical circuit time of optical dynamic therapy laser system of exposure stage
Meet △ t=t0-t2, t0For the electronic CCD or CMOS optical systems CCD or CMOS in the time for exposure of exposure stage, t2
Separate the time for the light path of the optical dynamic therapy laser system；
Wherein, as △ t≤0, expression separates light path, the output optical fibre in electronic CCD or CMOS optical system exposure stages
Treatment laser is not exported in exposure stage；
As 0 ＜ △ t≤0.5t0When, represent the last △ t time momentary connections in electronic CCD or CMOS optical system exposure stages
Light path, the output optical fibre exports transient therapy laser in exposure stage.
8. photodynamic therapy system as claimed in claim 1, it is characterised in that the optical dynamic therapy LASER Light Source output
The output power range for treating laser is 0W-3W；The output optical fibre is end face output optical fibre or side output optical fibre, the side
The light extraction zone length of face output optical fibre is 10mm-200mm.
9. photodynamic therapy system as claimed in claim 1, it is characterised in that the electronic CCD or CMOS optical systems
Diameter is not more than 5.0mm, chip size≤1/4 of the CCD or CMOS ", and the valid pixel of the CCD or CMOS are not less than 48
Ten thousand, the angle of view of the CCD or CMOS are not less than 100 °.
10. photodynamic therapy system as claimed in claim 1, it is characterised in that the material of the soft scope end is soft
Property material, its bendable front end；The diameter of the instrument channel is not more than 5mm.
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