CN101972133A - Multifunctional fluorescence diagnosis and photodynamic therapy endoscopic diagnosis and treatment system - Google Patents
Multifunctional fluorescence diagnosis and photodynamic therapy endoscopic diagnosis and treatment system Download PDFInfo
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- CN101972133A CN101972133A CN 201010538806 CN201010538806A CN101972133A CN 101972133 A CN101972133 A CN 101972133A CN 201010538806 CN201010538806 CN 201010538806 CN 201010538806 A CN201010538806 A CN 201010538806A CN 101972133 A CN101972133 A CN 101972133A
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Abstract
The invention relates to a multifunctional fluorescence diagnosis and photodynamic therapy endoscopic diagnosis and treatment system which is characterized by comprising a computer, a light source control device, an endoscope and an imaging device, wherein the computer is connected with the light source control device; the light source control device comprises a red-ray semiconductor laser, a blue-ray semiconductor laser and a white-ray light source; the red-ray semiconductor laser and the blue-ray semiconductor laser output laser respectively through a two-in-one fiber coupling module; the endoscope is connected with the computer through the imaging device; and the main body of the endoscope is connected with the light source control device. The invention has the advantages that the system integrates the three functions of ordinary celiac diagnosis, a tumor fluorescence diagnosis image system and tumor photodynamic therapy into a whole; the system not only can be used for ordinary diagnosis by adopting a white-ray light source, but also can be used for carrying out fluorescence diagnosis by adopting a blue-ray light source, and also can be used for carrying out photodynamic therapy by adopting a red-ray light source; and the three light sources can be simply and conveniently switched.
Description
Technical field
The invention belongs to medical apparatus and instruments, relate in particular to a kind of multi-functional fluorescence diagnosis and optical dynamic therapy endoscope diagnosis system.
Background technology
Traditional endoscope can enter tissue to carrying out visual inspection in the body, has improved the diagnostic level to the in-vivo tumour tissue, but because the restriction of technical specifications such as resolution can't be accomplished examination for the minute lesion tissue that naked eyes can not be discerned.At present, the endoscope of fluorescence diagnosis function has appearred having in the world, the laser fluorescence diagnosis is to adopt affine fluorescent agent in the laser deexcitation tumor cell, produce the fluorescent effect different with normal surrounding tissue, can clearly show tumor tissues shape and position, make the doctor be easy to distinguish and diagnose the small tumor tissues that is invisible to the naked eye.The domestic bibliographical information of having seen the peritoneoscope system, as: Zhang Wenjie, Deng (No.1 Hospital Affiliated to Zhongshan Univ.'s department of obstetrics and gynecology) " photodynamic therapy application in the recurrent ovarian carcinoma diagnosis and treatment under the peritoneoscope " Chinese laser medical journal, 2006 (6): the 395-398 photosensitizer can be absorbed and retention by tumor tissues by selectivity, sends the diagnosis that characteristic fluorescence can be used for tumor focus through the specific wavelength laser irradiation; Simultaneously, photosensitizer brings out photochemical reaction under the specific wavelength laser irradiation, produces cytotoxicity, can kill tumor cell, and 5-aminolevulinic acid photodynamic therapy can improve the positive diagnosing rate of recurrent ovarian carcinoma under the peritoneoscope; Crouse's Abraham-Fuchs (Siemens Company) " with abdominal cavity mechanical hand laser therapy the time, locating the method for gastrointestinal tract inner disease foci automatically " CN 1654011, when being used to for one kind adopt abdominal cavity mechanical hand laser therapy, 2005-08-17 in gastrointestinal tract, locatees the method for focus automatically, utilize the camera of abdominal cavity mechanical hand to take the gastrointestinal surface image, surface image is transferred to computer, analyze described surface image in concrete focus characteristic according to the focus that will shine by this computer based, calculate the adjustment signal by this computer based in the focus of being discerned, described adjustment signal is transferred to the abdominal cavity manipulator controller and/or is on the laser system in the abdominal cavity mechanical hand, and the orientation of the laser beam that calculates by the abdominal cavity manipulator controller and/or by the laser system adjustment based on this adjustment signal and size of laser irradiation area etc.Although but the endoscope that has fluorescence diagnosis has better visuality, does not also have treatment of diseases functions such as tumors.Therefore, demand urgently clinically researching and developing a kind of have the diagnosis and the treatment function synthesized in the multi-functional endoscope of one.
Summary of the invention
The present invention is in order to overcome deficiency of the prior art, a kind of multi-functional fluorescence diagnosis and optical dynamic therapy endoscope diagnosis system to be provided, and it has the common diagnosis in abdominal cavity, tumor fluorescence diagnosis image system and three kinds of functions of photodynamic tumor treatment in one; Not only can adopt white light source to carry out common diagnosis, but also can adopt blue light source to carry out fluorescence diagnosis and still can adopt red-light source to carry out optical dynamic therapy, three light sources can carry out easy switching.
The present invention for achieving the above object, be achieved through the following technical solutions, a kind of multi-functional fluorescence diagnosis and optical dynamic therapy endoscope diagnosis system, it is characterized in that: mainly by computer, light source control device, endoscope and imaging device constitute, described computer is connected with light source control device, described light source control device comprises red light semiconductor laser, blue-light semiconductor laser instrument and white light source, described red light semiconductor laser, the blue-light semiconductor laser instrument is respectively by two-in-one fiber coupling module output laser, described endoscope is connected with computer by imaging device, and endoscope main body is connected with light source control device.
Described endoscope mainly constitutes optical system by object lens, post mirror system and eyepiece, and imaging device is made of endoscope and CCD photographic head, and imaging device is connected with display with main frame.
Conduct the optical fiber of common white radiant in described endoscope main body is provided with and set up an optical fiber and an optical fiber coupling interface that is used to conduct blue laser, red laser.
Beneficial effect: have the common diagnosis in abdominal cavity, tumor fluorescence diagnosis image system and three kinds of functions of photodynamic tumor treatment in one; Not only can adopt white light source to carry out common diagnosis, but also can adopt blue light source to carry out fluorescence diagnosis and still can adopt red-light source to carry out optical dynamic therapy, three light sources can carry out easy switching.In establish endoscope, fluorescence diagnosis image system and laser therapeutic system, function is complete, cost is low, have good cost performance, help the popularization of multi-functional fluorescence diagnosis and optical dynamic therapy endoscope diagnosis system, the medical level that promotes China is had facilitation energetically.
Description of drawings
Fig. 1 is a syndeton schematic diagram of the present invention;
Fig. 2 is an endoscope diagnosis system syndeton sketch map;
Fig. 3 is the endoscope structure sketch map;
Fig. 4 is the mirror body section figure of endoscope;
Fig. 5 is the light source control device sketch map;
Fig. 6 is the operating process block diagram.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention: see accompanying drawing for details, a kind of multi-functional fluorescence diagnosis and optical dynamic therapy endoscope diagnosis system, mainly by computer, light source control device, endoscope and imaging device constitute, described computer is connected with light source control device, described light source control device comprises red light semiconductor laser, blue-light semiconductor laser instrument and white light source, described red light semiconductor laser, the blue-light semiconductor laser instrument is respectively by two-in-one fiber coupling module output laser, described endoscope is connected with computer by imaging device, and endoscope main body is connected with light source control device.Described endoscope mainly constitutes optical system by object lens 1, post mirror system 2 and eyepiece 3, and imaging device is made of endoscope and CCD photographic head 4, and imaging device is connected with display with main frame.Conduct the optical fiber 5 of common white radiant in described endoscope main body is provided with and set up an optical fiber 6 and an optical fiber coupling interface 7 that is used to conduct blue laser, red laser.
Operation principle: light power tumor laser therapeutic system part, the red light semiconductor laser module, configuration corresponding driving power supply and control system, be connected with endoscope main body, laser irradiation by specific wavelength makes it to produce corresponding cell toxicant to reach the purpose of kill tumor cell attached to the photosensitizer on the tumor cell.
When this system of use, when adopting white light, can carry out the common diagnosis of endoscope to the patient; When adopting the blue light input, can carry out the tumor fluorescence diagnosis; When using HONGGUANG, shine accumulating in tumor tissues photosensitizer on every side by HONGGUANG, make it to carry out photochemical reflection with the tissue macromole, produce cell toxicant, kill cancer cell reaches the purpose for the treatment of tumor.
Multi-functional fluorescence diagnosis and optical dynamic therapy endoscope diagnosis system are opened white light source by the computer control light source control device and are illuminated when injected organism tissue, carry out common diagnosis via endoscopic imaging to computer; The computer control light source control device is opened blue light source, carries out fluorescence diagnosis, and image is presented on the computer screen through endoscope and imaging system; The computer control light source control device is opened red-light source, carries out optical dynamic therapy.
Work process: start-up system at first, endoscope is imported in the body, open white light source the patient is carried out common diagnosis; When suspecting that there is tumor in human body, close white light, open blue light and carry out fluorescence diagnosis, determine the position and the shape of tumor by fluorescence diagnosis, close blue light, open HONGGUANG, tumor tissues is carried out optical dynamic therapy, treatment finishes the back shutdown system.
The above only is preferred embodiment of the present invention, is not structure of the present invention is done any pro forma restriction.Every foundation technical spirit of the present invention all still belongs in the scope of technical scheme of the present invention any simple modification, equivalent variations and modification that above embodiment did.
Claims (3)
1. multi-functional fluorescence diagnosis and optical dynamic therapy endoscope diagnosis system, it is characterized in that: mainly constitute by computer, light source control device, endoscope and imaging device, described computer is connected with light source control device, described light source control device comprises red light semiconductor laser, blue-light semiconductor laser instrument and white light source, described red light semiconductor laser, blue-light semiconductor laser instrument are respectively by two-in-one fiber coupling module output laser, described endoscope is connected with computer by imaging device, and endoscope main body is connected with light source control device.
2. according to described multi-functional fluorescence diagnosis of claim 1 and optical dynamic therapy endoscope diagnosis system, it is characterized in that: described endoscope mainly constitutes optical system by object lens, post mirror system and eyepiece, imaging device is made of endoscope and CCD photographic head, and imaging device is connected with display with main frame.
3. according to claim 1 or 2 described multi-functional fluorescence diagnosis and optical dynamic therapy endoscope diagnosis systems, it is characterized in that: conduct the optical fiber of common white radiant in described endoscope main body is provided with and set up an optical fiber and an optical fiber coupling interface that is used to conduct blue laser, red laser.
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Cited By (11)
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| CN102871634A (en) * | 2012-09-28 | 2013-01-16 | 中国科学院深圳先进技术研究院 | Laser endoscope system and diagnosis and therapy method thereof |
| CN104740789A (en) * | 2015-01-23 | 2015-07-01 | 国医华科（苏州）医疗科技发展有限公司 | Bed type treatment device for tumor treatment with laser |
| CN105769127A (en) * | 2016-05-05 | 2016-07-20 | 中国科学院苏州生物医学工程技术研究所 | Diagnosis and treatment equipment based on confocal technology and control method thereof |
| CN106308731A (en) * | 2016-08-31 | 2017-01-11 | 北京数字精准医疗科技有限公司 | Endoscopic multi-spectrum excited imaging system |
| CN107449736A (en) * | 2017-09-29 | 2017-12-08 | 南京科兴新材料科技有限公司 | A kind of Pharmaceutical Analysis instrument for being used to treat tumour |
| CN107485359A (en) * | 2017-09-21 | 2017-12-19 | 王俊铎 | Diagnostor is peeped in a kind of clinical medicine |
| CN107510431A (en) * | 2016-06-17 | 2017-12-26 | 奥斯奥鹏外科产品股份公司 | A kind of macromolecule medical endoscopes |
| CN107677641A (en) * | 2017-09-29 | 2018-02-09 | 南京科兴新材料科技有限公司 | A kind of helicobacter pylori diagnostor |
| CN113164007A (en) * | 2018-12-10 | 2021-07-23 | 奥林巴斯株式会社 | Image recording apparatus |
| CN113648547A (en) * | 2021-09-01 | 2021-11-16 | 北京理工大学 | Photodynamic accurate diagnosis and treatment device under guidance of multimode image and working method thereof |
| CN116548899A (en) * | 2023-04-19 | 2023-08-08 | 之江实验室 | Optical endoscopic diagnosis and treatment system and electronic device |
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| CN102871634A (en) * | 2012-09-28 | 2013-01-16 | 中国科学院深圳先进技术研究院 | Laser endoscope system and diagnosis and therapy method thereof |
| CN104740789A (en) * | 2015-01-23 | 2015-07-01 | 国医华科（苏州）医疗科技发展有限公司 | Bed type treatment device for tumor treatment with laser |
| CN105769127A (en) * | 2016-05-05 | 2016-07-20 | 中国科学院苏州生物医学工程技术研究所 | Diagnosis and treatment equipment based on confocal technology and control method thereof |
| CN105769127B (en) * | 2016-05-05 | 2019-03-29 | 中国科学院苏州生物医学工程技术研究所 | A kind of diagnostic equipment and its control method burnt based on copolymerization |
| CN107510431A (en) * | 2016-06-17 | 2017-12-26 | 奥斯奥鹏外科产品股份公司 | A kind of macromolecule medical endoscopes |
| CN106308731A (en) * | 2016-08-31 | 2017-01-11 | 北京数字精准医疗科技有限公司 | Endoscopic multi-spectrum excited imaging system |
| CN107485359A (en) * | 2017-09-21 | 2017-12-19 | 王俊铎 | Diagnostor is peeped in a kind of clinical medicine |
| CN107677641A (en) * | 2017-09-29 | 2018-02-09 | 南京科兴新材料科技有限公司 | A kind of helicobacter pylori diagnostor |
| CN107449736A (en) * | 2017-09-29 | 2017-12-08 | 南京科兴新材料科技有限公司 | A kind of Pharmaceutical Analysis instrument for being used to treat tumour |
| CN113164007A (en) * | 2018-12-10 | 2021-07-23 | 奥林巴斯株式会社 | Image recording apparatus |
| CN113648547A (en) * | 2021-09-01 | 2021-11-16 | 北京理工大学 | Photodynamic accurate diagnosis and treatment device under guidance of multimode image and working method thereof |
| CN113648547B (en) * | 2021-09-01 | 2022-11-22 | 北京理工大学 | Photodynamic accurate diagnosis and treatment device under guidance of multimode images |
| CN116548899A (en) * | 2023-04-19 | 2023-08-08 | 之江实验室 | Optical endoscopic diagnosis and treatment system and electronic device |
| CN116548899B (en) * | 2023-04-19 | 2024-02-06 | 之江实验室 | Optical endoscopic diagnosis and treatment system and electronic device |
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Application publication date: 20110216 |