CN106308731A - Endoscopic multi-spectrum excited imaging system - Google Patents
Endoscopic multi-spectrum excited imaging system Download PDFInfo
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- CN106308731A CN106308731A CN201610794405.6A CN201610794405A CN106308731A CN 106308731 A CN106308731 A CN 106308731A CN 201610794405 A CN201610794405 A CN 201610794405A CN 106308731 A CN106308731 A CN 106308731A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00163—Optical arrangements
- A61B1/00165—Optical arrangements with light-conductive means, e.g. fibre optics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/043—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
- A61B1/063—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements for monochromatic or narrow-band illumination
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
- A61B1/0646—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements with illumination filters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
- A61B1/0661—Endoscope light sources
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
- A61B1/07—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
- A61B5/0035—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
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Abstract
The invention provides an endoscopic multi-spectrum excited imaging system which comprises a laser source part, a white light source part, a light coupling part and an endoscopic imaging part. The laser source part and the white light source part are respectively connected with the light coupling part, the light coupling part is connected with the endoscopic imaging part, and the laser source part comprises at least one laser source. One of at least one laser source emits laser, the white light source part emits white light, and the laser and the white light are fused through the light coupling part and then enter the endoscopic imaging part so as to achieve multi-spectrum excited imaging. The endoscopic multi-spectrum excited imaging system can select laser spectra of the laser source part according to the imaging demands and adjusts the light source powers of the laser source part and the white light source part, the laser source is high in power, a spectral band is narrow, the imaging contrast ratio is high, spectral bands are flexible and convenient to select, and the imaging demand of a multi-spectrum endoscope is met.
Description
Technical field
The present invention relates to endoscope illuminator and technical field of imaging, particularly relating to the multispectral picture that is excited into of a kind of inner peeping type is
System.
Background technology
White light endoscopic is a kind of common checking tool, has the advantages such as invasive is low, wound is little.White light endoscopic leads to
Clear high-quality coloured image often can be provided, conveniently check diseased region and need not out abdomen, but due to some pathological changes
Position or important structure have similar shape, color etc. with normal portions, distinguish pathological changes portion only by coloured image
There is certain difficulty in position and normal portions.
In recent years, optical molecular image technology is increasingly becoming study hotspot, and it can observe cell knot on a molecular scale
Structure makes a variation, and wherein fluorescent molecules imaging technology is as an important branch of optical molecular iconography, by high specific, height
Spatial resolution, high time resolution, the advantage such as fast and convenient, achieve good development, in recent years fluorescent molecules imaging skill
Art is applied in pathological tissues identification also achieve preferably progress.
Fluorescent molecules imaging technology is applied in endoscopic imaging, can improve image contrast, fluorescent specific labelling
Position can help to identify specific position.And in order to not lose color image information, white light becomes with the fluorescence dual pathways simultaneously
Picture, demarcation specific part that can be real-time in coloured image, it is provided that more imaging region information.
For existing white fluorescence dual pathways imaging, multispectral excitation source typically uses the illumination of full spectral coverage to add optical filter
The mode of switching produces multiple excitation spectrum light source, and this mode exists that excitation source power is little, spectral band width, imaging pair
The problem higher than degree.
Summary of the invention
(1) to solve the technical problem that
In order to solve the problem that prior art exists, the invention provides that a kind of inner peeping type is multispectral excites imaging system.
(2) technical scheme
The invention provides that a kind of inner peeping type is multispectral excites imaging system, including: laser light source unit 200, white light source
Portion 100, optical coupling portion 400 and based endoscopic imaging portion 500；Wherein, described laser light source unit 200 and white light source portion 100 connect respectively
Meeting described optical coupling portion 400, described optical coupling portion 400 connects described based endoscopic imaging portion 500, and described laser light source unit 200 includes
At least one LASER Light Source；One of them LASER Light Source at least one LASER Light Source described sends laser, described white light light
Source portion 100 sends white light, described laser and white light and enters described based endoscopic imaging portion 500 after described optical coupling portion 400 merges, real
Existing the most multispectral it is excited into picture.
(3) beneficial effect
Imaging system is excited to have following useful effect from technique scheme it can be seen that the inner peeping type of the present invention is multispectral
Really:
Control portion can select the laser spectrum of laser light source unit according to imaging demand, and regulates laser light source unit with white
The light source power in radiant portion, excitation source power is big, spectral band is narrow, and image contrast is high, and the selection of spectral band is flexible
Convenient, meet the imaging demand of multi-spectrum endoscopic.
Accompanying drawing explanation
Fig. 1 is the multispectral overall schematic exciting imaging system of inner peeping type of the embodiment of the present invention；
Fig. 2 be the embodiment of the present invention the structure chart in optical coupling portion；
Fig. 3 is the multispectral structure chart exciting imaging system of inner peeping type of the embodiment of the present invention.
[symbol description]
100-white light source portion；200-laser light source unit；300-control portion；400-optical coupling portion；500 based endoscopic imaging portions；
600-image processing part；
201-LASER Light Source one；202-LASER Light Source two；203-LASER Light Source three；401-white light source interface；402-swashs
Radiant interface；403-white light optical fiber；404-laser fiber；405-fiber coupler；406-multimode fibre；407-optical tunnel；
408-endoscope illuminator interface；501-imaging section；502-endoscopic portion；503-search coverage.
Detailed description of the invention
The present invention is that a kind of inner peeping type is multispectral excites imaging system, and this system includes: white light source portion, is provided that three
The excitation source portion of spectral coverage laser, optical coupling portion, its by white light and laser fusion to together with, be simultaneously fed into endoscopic portion, control
Portion, it controls white light source and the output of excitation source and regulation light source power；Endoscopic imaging portion, carries out multispectral imaging.
Multiple spectral coverage light are merged by the present invention by light path fusion method, can produce the exciting light of multiple single spectral coverage simultaneously, meet many
The imaging demand of spectrum endoscope.
For making the object, technical solutions and advantages of the present invention clearer, below in conjunction with specific embodiment, and reference
Accompanying drawing, the present invention is described in more detail.
In embodiments of the present invention, as shown in Figure 1, it is provided that a kind of inner peeping type is multispectral excites imaging system, including: swash
Radiant portion 200, white light source portion 100, optical coupling portion 400, control portion 300, based endoscopic imaging portion 500 and image processing part 600.
Wherein,
The most referring also to Fig. 3, laser light source unit 200 includes LASER Light Source 1, LASER Light Source 2 202 and LASER Light Source
3 203, LASER Light Source 1 sends the first laser that wave band is 785 ± 10nm, is used for exciting indocyanine green and IRDye800CW
Deng fluorescence imaging reagent, LASER Light Source 2 202 sends the second laser that wave band is 685 ± 10nm, is used for exciting IRDye680CW
Deng fluorescence imaging reagent；LASER Light Source 3 203 sends the 3rd laser that wave band is 390-440nm, for auto-fluorescence imaging；In vain
Radiant portion 100 sends the white light of 400-650nm wave band, for providing illumination to search coverage 503, and carries out visible ray one-tenth
Picture.
Referring to Fig. 2, optical coupling portion 400 sends for the white light and laser light source unit 200 merging white light source portion 100
Laser.Wherein, optical coupling portion 400 includes: white light optical fiber 403, laser fiber 404, fiber coupler 405, multimode fibre 406 and
Optical tunnel 407, optical coupling portion 400 is connected with white light source portion 100 by white light source interface 401, white light source interface 401
Connecting fiber coupler 405 through white light optical fiber 403, optical coupling portion 400 is by LASER Light Source interface 402 and laser light source unit 200
Being connected, LASER Light Source interface 402 connects fiber coupler 405 through laser fiber 404, and fiber coupler 405 is through multimode fibre
406 connect optical tunnel 407, and optical tunnel 407 connects endoscopic imaging portion 500 through endoscope illuminator interface 408.
Wherein, white light optical fiber 403 and laser fiber 404 are coupled as multimode fibre 406 by fiber coupler 405, and it passes through
By white light optical fiber 403 and laser fiber 404 and together with burn and melt stretching, optical fiber nuclear core condenses together formation multimode fibre 406.
Optical tunnel 407 can be polygon glass column, it is also possible to be inwall be the ducted body of reflecting surface, incide even light
The light of rod inwall reaches the purpose of uniform light after multiple reflections.
Control portion 300 connects white light source portion 100 and laser light source unit 200, and it selects LASER Light Source according to imaging demand
The laser spectrum in portion 200, and regulate laser light source unit 200 and the light source power in white light source portion 100.
Control portion 300 can use the controller such as computer, single-chip microcomputer.
Based endoscopic imaging portion 500 includes imaging section 501 and endoscopic portion 502, and is connected with image processing part 600, wherein, becomes
As portion 501 includes that white light camera and fluorescence camera, endoscopic portion 502 include endoscope illuminator introducing port, imaging light guide bundles and swash
Issue permit bright light guide bundles.Endoscope illuminator introducing port mates with the endoscope illuminator interface 408 in optical coupling portion 400, endoscope illuminator
Interface 408 can thread directly into endoscope illuminator introducing port, convenient operation, it is easy to dismounting by screw socket.Fluorescence camera can include
Near-infrared fluorescent camera and Cerenkov fluorescence camera.
The multispectral imaging system that excites of the inner peeping type of the embodiment of the present invention, laser light source unit 200 and 100, white light source portion
Going out laser and white light, white light enters optical coupling portion 400 by white light source interface 401, and enters optical fiber coupling through white light optical fiber 403
Clutch 405；Laser enters optical coupling portion 400 by LASER Light Source interface 402, and enters fiber coupler through laser fiber 404
405；
Fiber coupler 405 by white light together with laser fusion, and in multimode fibre 406 sends into optical tunnel 407, warp
After the uniformly collimation of optical tunnel 407, send into based endoscopic imaging portion by endoscope illuminator interface 408 and endoscope illuminator introducing port
500, and through exciting illumination light guide bundles to irradiate search coverage 503, the imaged light guide bundles of light reflecting from search coverage 503 or sending
Enter imaging section 501, by white light camera and fluorescence camera imaging, and image is sent into image processing part 600 process, thus
Obtain colour-fluorescent fusion image.Wherein, control portion 300 can select the laser light of laser light source unit 200 according to imaging demand
Spectrum, specifically, control portion 300 controls LASER Light Source 1, LASER Light Source 2 202 and LASER Light Source 3 203, select wherein it
One sends laser, during for example, it is desired to excite the fluorescence imaging reagent such as indocyanine green and IRDye800CW, selects LASER Light Source one
201 send the first laser, when needing to excite the fluorescence imaging reagent such as IRDye680CW, select LASER Light Source 2 202 to send
Second laser, when needing auto-fluorescence imaging, selects LASER Light Source 3 203 to send the 3rd laser；And laser light can be regulated
Source 1, LASER Light Source 2 202, LASER Light Source 3 203 and the light source power in white light source portion 100, to realize multispectral exciting
Imaging.
As can be seen here, the multispectral imaging system that excites of the inner peeping type of the present invention, control portion can select according to imaging demand
The laser spectrum of laser light source unit, and regulate laser light source unit and the light source power in white light source portion, relative to prior art
Multispectral excitation source use full spectral coverage illumination add optical filter switching mode produce multiple excitation spectrum light source, excitation source
Power is big, and spectral band is narrow, and the selection of spectral band is flexible, meets the imaging demand of multi-spectrum endoscopic.
So far, already in connection with accompanying drawing, the present embodiment has been described in detail.According to above description, those skilled in the art
Imaging system should be excited to have had clearly recognize to the inner peeping type of the present invention is multispectral.
It should be noted that in accompanying drawing or description text, the implementation not illustrating or describing, it is affiliated technology
In field, form known to a person of ordinary skill in the art, is not described in detail.Additionally, the above-mentioned definition to each element not only limiting
Various concrete structures, shape or the mode mentioned in embodiment, it can be carried out the most more by those of ordinary skill in the art
Change or replace, such as:
(1) the direction term mentioned in embodiment, such as " on ", D score, "front", "rear", "left", "right" etc., be only ginseng
Examine the direction of accompanying drawing, be not used for limiting the scope of the invention；
(2) above-described embodiment can based on design and the consideration of reliability, being mixed with each other collocation use or with other embodiments
Mix and match uses, and the technical characteristic in i.e. different embodiments can freely form more embodiment.
In sum, the multispectral imaging system that excites of the inner peeping type of the present invention, control portion can select according to imaging demand
The laser spectrum of laser light source unit, and regulate laser light source unit and the light source power in white light source portion, relative to prior art
Multispectral excitation source use full spectral coverage illumination add optical filter switching mode produce multiple excitation spectrum light source, excitation source
Power is big, and spectral band is narrow, and the selection of spectral band is flexible, meets the imaging demand of multi-spectrum endoscopic.
Particular embodiments described above, has been carried out the purpose of the present invention, technical scheme and beneficial effect the most in detail
Describe in detail bright, be it should be understood that the specific embodiment that the foregoing is only the present invention, be not limited to the present invention, all
Within the spirit and principles in the present invention, any modification, equivalent substitution and improvement etc. done, should be included in the guarantor of the present invention
Within the scope of protecting.
Claims (10)
1. an inner peeping type is multispectral excites imaging system, it is characterised in that including: laser light source unit (200), white light source portion
(100), optical coupling portion (400) and based endoscopic imaging portion (500)；Wherein,
Described laser light source unit (200) and white light source portion (100) connect described optical coupling portion (400), described optical coupling respectively
Portion (400) connects described based endoscopic imaging portion (500), and described laser light source unit (200) includes at least one LASER Light Source；
One of them LASER Light Source at least one LASER Light Source described sends laser, and described white light source portion (100) sends
White light, described laser and white light enter described based endoscopic imaging portion (500) after described optical coupling portion (400) is merged, it is achieved how light
Spectrum is excited into picture.
2. inner peeping type is multispectral as claimed in claim 1 excites imaging system, it is characterised in that also include: control portion
(300)；
Described control portion (300) connects described white light source portion (100) and laser light source unit (200), and it selects according to imaging demand
One of them LASER Light Source selected at least one LASER Light Source described sends laser, and regulates described LASER Light Source and white light light
The light source power in source portion (100).
3. inner peeping type is multispectral as claimed in claim 1 excites imaging system, it is characterised in that
Described optical coupling portion (400) including: white light source interface (401), LASER Light Source interface (402), white light optical fiber (403),
Laser fiber (404), fiber coupler (405), multimode fibre (406), optical tunnel (407) and endoscope illuminator interface (408)；
Wherein,
Described white light source interface (401) is connected with white light source portion (100), and described white light source interface (401) is through white light light
Fine (403) connect fiber coupler (405), and described LASER Light Source interface (402) is connected with laser light source unit (200), described sharp
Radiant interface (402) connects fiber coupler (405) through laser fiber (404), and described fiber coupler (405) is through multimode light
Fine (406) connect optical tunnel (407), and described optical tunnel (407) connects endoscopic imaging portion through endoscope illuminator interface (408)
(500)。
4. inner peeping type is multispectral as claimed in claim 3 excites imaging system, it is characterised in that
Described white light enters optical coupling portion (400) by white light source interface (401), and enters through described white light optical fiber (403)
Fiber coupler (405)；Described laser enters optical coupling portion (400) by LASER Light Source interface (402), and through laser fiber
(404) fiber coupler (405) is entered；
Described fiber coupler (405) by white light together with laser fusion, and through described multimode fibre (406) send into optical tunnel
(407), in, after described optical tunnel (407) uniformly collimation, based endoscopic imaging portion is sent into by described endoscope illuminator interface (408)
(500)。
5. inner peeping type is multispectral as claimed in claim 3 excites imaging system, it is characterised in that described based endoscopic imaging portion
(500) endoscopic portion (502) is included；
Described endoscopic portion (502) including: endoscope illuminator introducing port, and described endoscope illuminator introducing port is interior with optical coupling portion
Endoscope light source interface (408) mates, and described endoscope illuminator interface (408) threads directly into endoscope illuminator by screw socket and imports
Mouthful.
6. inner peeping type is multispectral as claimed in claim 3 excites imaging system, it is characterised in that described optical tunnel (407) is
Polygon glass column, or inwall is the ducted body of reflecting surface.
7. inner peeping type is multispectral as claimed in claim 5 excites imaging system, it is characterised in that also include: image processing part
(600)；Described based endoscopic imaging portion (500) also includes: imaging section (501), and is connected with described image processing part (600)；Described
Endoscopic portion (502) also includes: imaging light guide bundles and excite illumination light guide bundles；
Illumination light guide bundles is excited to irradiate search coverage (503) by described in the laser after optical coupling portion (400) fusion and white light warp, from
Described search coverage (503) reflects or the light that sends enters imaging section (501), described imaging section through described imaging light guide bundles
(501) image is sent into image processing part (600) to process, obtain colour-fluorescent fusion image.
8. inner peeping type is multispectral as claimed in claim 1 excites imaging system, it is characterised in that at least one laser light described
Source includes: LASER Light Source one (201), LASER Light Source two (202) and LASER Light Source three (203)；Wherein,
Described LASER Light Source one (201) is the laser instrument of 785 ± 10nm wave band, is used for exciting indocyanine green and IRDye800CW glimmering
Photoimaging reagent；
Described LASER Light Source two (202) is the laser instrument of 685 ± 10nm wave band, is used for exciting IRDye680CW fluorescence imaging to try
Agent；
Described LASER Light Source three (203) is the laser instrument of 390-440nm wave band, for auto-fluorescence imaging；
Described white light source portion (100) is the white light source of 400-650nm wave band, for providing illumination to search coverage (503), and
Carry out visual light imaging.
9. inner peeping type is multispectral as claimed in claim 7 excites imaging system, it is characterised in that described imaging section (501) is wrapped
Include: white light camera and fluorescence camera.
10. inner peeping type is multispectral as claimed in claim 2 excites imaging system, it is characterised in that described control portion (300) is
Computer or single-chip microcomputer.
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| CN107149461A (en) * | 2017-04-26 | 2017-09-12 | 上海成运医疗器械股份有限公司 | The LED/light source and means of illumination of illumination are dyed for Medical endoscope spectrum |
| CN107174215A (en) * | 2017-06-28 | 2017-09-19 | 上海凯利泰医疗科技股份有限公司 | A kind of spy fluorescence monitoring apparatus |
| CN109222858A (en) * | 2018-11-19 | 2019-01-18 | 苏州新光维医疗科技有限公司 | Endoscope structure with various light sources |
| CN109270636A (en) * | 2018-10-26 | 2019-01-25 | 洪小苗 | The method and fixed device of a kind of fiber coupling into light balancing device |
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| CN111970953A (en) * | 2018-03-30 | 2020-11-20 | 光明之火生物科学公司 | System and method for simultaneous near-infrared and visible light imaging |
| CN113116302A (en) * | 2021-04-02 | 2021-07-16 | 中国科学院苏州生物医学工程技术研究所 | Endoscopic Raman spectrum detection system for early cancer screening |
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