CN206434300U - A kind of spy is multispectral to excite imaging system - Google Patents
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- CN206434300U CN206434300U CN201621028445.1U CN201621028445U CN206434300U CN 206434300 U CN206434300 U CN 206434300U CN 201621028445 U CN201621028445 U CN 201621028445U CN 206434300 U CN206434300 U CN 206434300U
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- 238000003384 imaging method Methods 0.000 title claims abstract description 97
- 230000005284 excitation Effects 0.000 claims abstract description 38
- 230000003287 optical effect Effects 0.000 claims abstract description 34
- 230000008878 coupling Effects 0.000 claims abstract description 33
- 238000010168 coupling process Methods 0.000 claims abstract description 33
- 238000005859 coupling reaction Methods 0.000 claims abstract description 33
- 239000013307 optical fiber Substances 0.000 claims description 39
- 239000000835 fiber Substances 0.000 claims description 21
- 238000012545 processing Methods 0.000 claims description 12
- 238000005286 illumination Methods 0.000 claims description 10
- 238000001514 detection method Methods 0.000 claims description 9
- 239000003153 chemical reaction reagent Substances 0.000 claims description 8
- 238000012632 fluorescent imaging Methods 0.000 claims description 8
- MOFVSTNWEDAEEK-UHFFFAOYSA-M indocyanine green Chemical compound [Na+].[O-]S(=O)(=O)CCCCN1C2=CC=C3C=CC=CC3=C2C(C)(C)C1=CC=CC=CC=CC1=[N+](CCCCS([O-])(=O)=O)C2=CC=C(C=CC=C3)C3=C2C1(C)C MOFVSTNWEDAEEK-UHFFFAOYSA-M 0.000 claims description 4
- 229960004657 indocyanine green Drugs 0.000 claims description 4
- 239000011521 glass Substances 0.000 claims description 3
- 238000001228 spectrum Methods 0.000 abstract description 12
- 230000003595 spectral effect Effects 0.000 abstract description 11
- 238000005516 engineering process Methods 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 5
- 238000000701 chemical imaging Methods 0.000 description 4
- 244000144985 peep Species 0.000 description 4
- 230000003902 lesion Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000004927 fusion Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000695 excitation spectrum Methods 0.000 description 1
- 238000002350 laparotomy Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
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Abstract
The utility model provides that a kind of spy is multispectral to excite imaging system, including：Laser light source unit, white light source portion, optical coupling portion and based endoscopic imaging portion, laser light source unit and white light source portion connect optical coupling portion respectively, and optical coupling portion connection based endoscopic imaging portion, laser light source unit includes at least one LASER Light Source；One of LASER Light Source at least one LASER Light Source sends laser, and white light source portion sends white light, and laser and white light enter based endoscopic imaging portion after being merged through optical coupling portion, realizes and multispectral is excited into picture.The multispectral laser spectrum for exciting imaging system to select laser light source unit according to imaging demand of spy of the present utility model, and adjust the light source power in laser light source unit and white light source portion, excitation source power is big, spectral band is narrow, image contrast is high, the selection of spectral band is flexible, meets the imaging demand of multi-spectrum endoscopic.
Description
Technical Field
The utility model relates to an endoscope light source and imaging technology field especially relate to an peep multispectral imaging system that arouses of formula.
Background
The white light endoscope is a common examination tool and has the advantages of low invasiveness, small wound and the like. The white light endoscope can generally provide a clear and high-quality color image, facilitate examination of a lesion site and do not require laparotomy, but since some lesion sites or important structures and normal sites have similar shapes, colors and the like, there is a certain difficulty in distinguishing the lesion site from the normal site only by the color image.
In recent years, optical molecular imaging technology has gradually become a research focus, which can observe the cell structure variation at the molecular level, wherein fluorescent molecular imaging technology is an important branch of optical molecular imaging, and has been well developed by virtue of the advantages of high specificity, high spatial resolution, high temporal resolution, rapidness, simplicity and convenience, and the like, and in recent years, the fluorescent molecular imaging technology has also been well developed for the identification of diseased tissues.
The fluorescent molecular imaging technology is applied to endoscope imaging, the imaging contrast can be improved, and the specific part can be identified by the fluorescent specific marked part. In addition, in order to avoid losing color image information, the white light and the fluorescence are imaged simultaneously, a specific part can be calibrated in real time in a color image, and more imaging area information is provided.
For the existing white light fluorescence dual-channel imaging, a multispectral excitation light source generally adopts a full-spectral-band illumination and filter switching mode to generate a plurality of excitation spectral light sources, and the mode has the problems of small excitation light source power, wide spectral band and low imaging contrast.
SUMMERY OF THE UTILITY MODEL
Technical problem to be solved
In order to solve the problems existing in the prior art, the utility model provides an endoscopic multispectral excitation imaging system.
(II) technical scheme
The utility model provides an peep multispectral imaging system that arouses of formula in, include: a laser light source part 200, a white light source part 100, an optical coupling part 400 and an endoscopic imaging part 500; the laser light source part 200 and the white light source part 100 are respectively connected with the optical coupling part 400, the optical coupling part 400 is connected with the endoscopic imaging part 500, and the laser light source part 200 comprises at least one laser light source; one of the at least one laser light source emits laser, the white light source portion 100 emits white light, and the laser and the white light enter the endoscopic imaging portion 500 after being fused by the optical coupling portion 400, so that multispectral excitation imaging is realized.
Preferably, the method further comprises the following steps: a control unit 300; the control part 300 is connected to the white light source part 100 and the laser light source part 200, and selects one of the at least one laser light source to emit laser light according to the imaging requirement, and adjusts the light source power of the laser light source and the white light source part 100.
Preferably, the optical coupling part 400 includes: a white light source interface 401, a laser light source interface 402, a white light fiber 403, a laser fiber 404, a fiber coupler 405, a multimode fiber 406, a light homogenizing rod 407 and an endoscope light source interface 408; the white light source interface 401 is connected to the white light source section 100, the white light source interface 401 is connected to the optical fiber coupler 405 through a white light fiber 403, the laser light source interface 402 is connected to the laser light source section 200, the laser light source interface 402 is connected to the optical fiber coupler 405 through a laser fiber 404, the optical fiber coupler 405 is connected to the light homogenizing rod 407 through a multimode fiber 406, and the light homogenizing rod 407 is connected to the endoscope imaging section 500 through an endoscope light source interface 408.
Preferably, the white light enters the optical coupling portion 400 through the white light source interface 401, and enters the optical fiber coupler 405 through the white light optical fiber 403; the laser enters the optical coupling portion 400 through the laser source interface 402 and enters the optical fiber coupler 405 through the laser fiber 404; the optical fiber coupler 405 fuses white light and laser together, and the fused white light and laser are sent into the light homogenizing rod 407 through the multimode optical fiber 406, and after being uniformly collimated by the light homogenizing rod 407, the fused white light and laser are sent into the endoscopic imaging part 500 through the endoscope light source interface 408.
Preferably, the endoscopic imaging portion 500 comprises an endoscopic portion 502; the endoscopic portion 502 includes: an endoscope light source introduction port which is matched with the endoscope light source interface 408 of the optical coupling section, and the endoscope light source interface 408 is directly screwed into the endoscope light source introduction port through a screw.
Preferably, the light homogenizing rod 407 is a polygonal glass cylinder, or a hollow body with a reflective surface on the inner wall.
Preferably, the method further comprises the following steps: an image processing unit 600; the endoscopic imaging portion 500 further comprises: an imaging part 501 connected to the image processing part 600; the endoscopic portion 502 further comprises: an imaging light guide beam and an excitation illumination light guide beam; the laser light and the white light fused by the optical coupling portion 400 irradiate the detection region 503 through the excitation illumination light guide beam, the light reflected or emitted from the detection region 503 enters the imaging portion 501 through the imaging light guide beam, and the imaging portion 501 sends the image to the image processing portion 600 for processing, so as to obtain a color-fluorescence fusion image.
Preferably, the at least one laser light source comprises: a first laser source 201, a second laser source 202 and a third laser source 203; the first laser source 201 is a laser with a wave band of 785 +/-10 nm and is used for exciting indocyanine green and IRDye800CW fluorescent imaging reagents; the second laser source 202 is a laser with a wave band of 685 +/-10 nm and is used for exciting IRDye680CW fluorescent imaging reagents; the third laser light source 203 is a laser with a wave band of 390-440nm and is used for autofluorescence imaging; the white light source part 100 is a white light source with a wavelength band of 400-650nm, and is used for illuminating the detection region 503 and performing visible light imaging.
Preferably, the imaging section 501 includes: white light cameras and fluorescence cameras.
Preferably, the control part 300 is a computer or a single chip microcomputer.
(III) advantageous effects
According to the above technical scheme, the utility model discloses an peep multispectral excitation imaging system of formula has following beneficial effect:
the control part can select the laser spectrum of the laser light source part according to the imaging requirement and adjust the light source power of the laser light source part and the white light source part, the excitation light source power is large, the spectrum wave band is narrow, the imaging contrast is high, the selection of the spectrum wave band is flexible and convenient, and the imaging requirement of the multispectral endoscope is met.
Drawings
Fig. 1 is an overall schematic view of an endoscopic multispectral excitation imaging system according to an embodiment of the present invention;
FIG. 2 is a view showing a structure of an optical coupling section according to an embodiment of the present invention;
fig. 3 is a structural diagram of an endoscopic multispectral excitation imaging system according to an embodiment of the present invention.
[ notation ] to show
100-a white light source section; 200-laser light source part; 300-a control section; 400-an optical coupling section; 500 endoscopic imaging part; 600-an image processing section;
201-laser light source I; 202-laser light source two; 203-laser light source three; 401-white light source interface; 402-laser light source interface; 403-white light fiber; 404-laser fiber; 405-a fiber coupler; 406 — a multimode optical fiber; 407-dodging rod; 408-endoscope light source interface; 501-an imaging part; 502-an endoscopic portion; 503-detection zone.
Detailed Description
The utility model relates to an peep multispectral imaging system that arouses of formula in, this system includes: a white light source part, an excitation light source part which can provide three spectral band laser, an optical coupling part which fuses the white light and the laser together and sends the fused white light and the laser into the endoscope part, and a control part which controls the output of the white light source and the excitation light source and adjusts the power of the light source; and an endoscope imaging unit for performing multispectral imaging. The utility model discloses a light path fuses the method with a plurality of spectral bands light fusion, can produce the exciting light of a plurality of single spectral bands simultaneously, satisfies multispectral endoscope's formation of image demand.
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in detail with reference to the accompanying drawings.
In an embodiment of the present invention, as shown in fig. 1, there is provided an endoscopic multispectral excitation imaging system, including: the endoscope comprises a laser light source part 200, a white light source part 100, an optical coupling part 400, a control part 300, an endoscopic imaging part 500 and an image processing part 600. Wherein,
referring to fig. 3, the laser light source section 200 includes a first laser light source 201, a second laser light source 202 and a third laser light source 203, the first laser light source 201 emits a first laser light with a wavelength band of 785 ± 10nm for exciting fluorescent imaging reagents such as indocyanine green and IRDye800CW, the second laser light source 202 emits a second laser light with a wavelength band of 685 ± 10nm for exciting fluorescent imaging reagents such as IRDye680 CW; the laser light source III 203 emits a third laser with the wave band of 390-440nm for autofluorescence imaging; the white light source part 100 emits white light of 400-650nm wavelength band for illuminating the detection region 503 and performing visible light imaging.
Referring to fig. 2, the optical coupling portion 400 is used to combine the white light of the white light source portion 100 and the laser light emitted from the laser light source portion 200. Wherein, the optical coupling part 400 includes: the endoscope imaging system comprises a white light optical fiber 403, a laser optical fiber 404, an optical fiber coupler 405, a multimode optical fiber 406 and a light homogenizing rod 407, wherein the optical coupling part 400 is connected with the white light source part 100 through a white light source interface 401, the white light source interface 401 is connected with the optical fiber coupler 405 through the white light optical fiber 403, the optical coupling part 400 is connected with the laser light source part 200 through a laser light source interface 402, the laser light source interface 402 is connected with the optical fiber coupler 405 through the laser optical fiber 404, the optical fiber coupler 405 is connected with the light homogenizing rod 407 through the multimode optical fiber 406, and the light homogenizing rod 407 is connected with the endoscope imaging part 500 through an.
The optical fiber coupler 405 couples the white light fiber 403 and the laser fiber 404 into a multimode optical fiber 406, and the optical fiber cores are fused together to form the multimode optical fiber 406 by fusing and stretching the white light fiber 403 and the laser fiber 404 together.
The light homogenizing rod 407 may be a polygonal glass cylinder, or may be a hollow body with an inner wall as a reflecting surface, and the light incident on the inner wall of the light homogenizing rod is reflected for multiple times to achieve the purpose of homogenizing the light.
The control part 300 connects the white light source part 100 and the laser light source part 200, selects a laser spectrum of the laser light source part 200 according to an imaging requirement, and adjusts light source powers of the laser light source part 200 and the white light source part 100.
The control unit 300 may be a computer, a single chip microcomputer, or other controller.
The endoscopic imaging part 500 comprises an imaging part 501 and an endoscopic part 502, and is connected with the image processing part 600, wherein the imaging part 501 comprises a white light camera and a fluorescence camera, and the endoscopic part 502 comprises an endoscope light source introducing port, an imaging light guide beam and an excitation illumination light guide beam. The endoscope light source introduction port is matched with the endoscope light source interface 408 of the optical coupling section 400, and the endoscope light source interface 408 can be directly screwed into the endoscope light source introduction port through a screw port, so that the operation is convenient and the detachment is easy. The fluorescence camera may include a near infrared fluorescence camera and a Cerenkov fluorescence camera.
In the endoscopic multispectral excitation imaging system of the embodiment of the present invention, the laser light source 200 and the white light source 100 emit laser light and white light, and the white light enters the optical coupling portion 400 through the white light source interface 401 and enters the optical fiber coupler 405 through the white light fiber 403; laser enters the optical coupling portion 400 through the laser source interface 402 and enters the optical fiber coupler 405 through the laser fiber 404;
the optical fiber coupler 405 fuses white light and laser together, the fused white light and laser are sent into the light homogenizing rod 407 through the multimode optical fiber 406, the fused white light and laser are sent into the endoscopic imaging part 500 through the endoscope light source interface 408 and the endoscope light source inlet after being uniformly collimated by the light homogenizing rod 407, the fused white light and laser are further sent into the endoscopic imaging part 503 through exciting the illumination light guide beam, light reflected or emitted from the detection region 503 enters the imaging part 501 through the imaging light guide beam, the imaging is carried out through the white light camera and the fluorescence camera, and the image is sent into the image processing part 600 to be processed, so that a color-fluorescence fused image is. The control unit 300 may select the laser spectrum of the laser light source unit 200 according to the imaging requirement, and specifically, the control unit 300 controls the first laser light source 201, the second laser light source 202, and the third laser light source 203 to select one of them to emit laser light, for example, when a fluorescent imaging reagent such as indocyanine green and IRDye800CW needs to be excited, the first laser light source 201 is selected to emit first laser light, when a fluorescent imaging reagent such as IRDye680CW needs to be excited, the second laser light source 202 is selected to emit second laser light, and when autofluorescence imaging is needed, the third laser light source 203 is selected to emit third laser light; and the light source power of the first laser source 201, the second laser source 202, the third laser source 203 and the white light source part 100 can be adjusted to realize multispectral excitation imaging.
Therefore, the utility model discloses an endoscopic multispectral arouses imaging system, the control part can select the laser spectrum of laser light source portion according to the formation of image demand to adjust the light source power of laser light source portion and white light source portion, adopt full spectral band illumination to add the mode of filter switching to produce a plurality of excitation spectral light sources for prior art's multispectral excitation light source, excitation light source power is big, the spectral band is narrow, and the selection of spectral band is nimble convenient, satisfies multispectral endoscope's formation of image demand.
Up to this point, the present embodiment has been described in detail with reference to the accompanying drawings. From the above description, those skilled in the art should clearly recognize the endoscopic multi-spectral excitation imaging system of the present invention.
It is to be noted that, in the attached drawings or in the description, the implementation modes not shown or described are all the modes known by the ordinary skilled person in the field of technology, and are not described in detail. In addition, the above definitions of the various elements are not limited to the specific structures, shapes or modes mentioned in the embodiments, and those skilled in the art may easily modify or replace them, for example:
(1) directional phrases used in the embodiments, such as "upper", "lower", "front", "rear", "left", "right", etc., refer only to the orientation of the drawings and are not intended to limit the scope of the present invention;
(2) the embodiments described above may be mixed and matched with each other or with other embodiments based on design and reliability considerations, i.e. technical features in different embodiments may be freely combined to form further embodiments.
To sum up, the utility model discloses an endoscopic multispectral arouses imaging system, the control part can select the laser spectrum of laser light source portion according to the formation of image demand to adjust the light source power of laser light source portion and white light source portion, adopt the full spectrum section illumination to add the mode that the filter switches and produce a plurality of excitation spectrum light sources for prior art's multispectral excitation light source, excitation light source power is big, and the spectrum wave band is narrow, and the selection of spectrum wave band is nimble convenient, satisfies multispectral endoscope's formation of image demand.
The above-mentioned embodiments, further detailed description of the objects, technical solutions and advantages of the present invention, it should be understood that the above-mentioned embodiments are only specific embodiments of the present invention, and are not intended to limit the present invention, and any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (10)
1. An endoscopic multi-spectral excitation imaging system, comprising: a laser light source part (200), a white light source part (100), an optical coupling part (400) and an endoscopic imaging part (500); wherein,
the laser light source part (200) and the white light source part (100) are respectively connected with the optical coupling part (400), the optical coupling part (400) is connected with the endoscopic imaging part (500), and the laser light source part (200) comprises at least one laser light source;
one of the at least one laser light source emits laser, the white light source part (100) emits white light, and the laser and the white light are fused by the optical coupling part (400) and then enter the endoscopic imaging part (500) to realize multispectral excitation imaging.
2. The endoscopic multispectral excitation imaging system according to claim 1, further comprising: a control unit (300);
the control part (300) is connected with the white light source part (100) and the laser light source part (200), selects one of the at least one laser light source to emit laser according to imaging requirements, and adjusts the light source power of the laser light source and the white light source part (100).
3. The endoscopic multi-spectral excitation imaging system according to claim 1,
the optical coupling section (400) includes: the system comprises a white light source interface (401), a laser light source interface (402), a white light fiber (403), a laser fiber (404), a fiber coupler (405), a multimode fiber (406), a light homogenizing rod (407) and an endoscope light source interface (408); wherein,
the white light source interface (401) is connected with the white light source part (100), the white light source interface (401) is connected with the optical fiber coupler (405) through a white light optical fiber (403), the laser light source interface (402) is connected with the laser light source part (200), the laser light source interface (402) is connected with the optical fiber coupler (405) through a laser optical fiber (404), the optical fiber coupler (405) is connected with the light homogenizing rod (407) through a multimode optical fiber (406), and the light homogenizing rod (407) is connected with the endoscope imaging part (500) through the endoscope light source interface (408).
4. The endoscopic multi-spectral excitation imaging system according to claim 3,
the white light enters the light coupling part (400) through the white light source interface (401) and enters the optical fiber coupler (405) through the white light optical fiber (403); the laser enters the optical coupling part (400) through the laser source interface (402) and enters the optical fiber coupler (405) through the laser optical fiber (404);
the optical fiber coupler (405) fuses white light and laser together, the white light and the laser are sent into a light homogenizing rod (407) through the multimode optical fiber (406), and the white light and the laser are sent into the endoscopic imaging part (500) through the endoscope light source interface (408) after being uniformly collimated by the light homogenizing rod (407).
5. The endoscopic multispectral excitation imaging system according to claim 3, wherein the endoscopic imaging portion (500) comprises an endoscopic portion (502);
the endoscopic portion (502) includes: an endoscope light source introduction port which is matched with an endoscope light source interface (408) of the optical coupling section, wherein the endoscope light source interface (408) is directly screwed into the endoscope light source introduction port through a screw port.
6. The endoscopic multispectral excitation imaging system according to claim 3, wherein the homogenizing rod (407) is a polygonal glass cylinder or a hollow body with reflective surfaces on its inner wall.
7. The endoscopic multispectral excitation imaging system according to claim 5, further comprising: an image processing unit (600); the endoscopic imaging portion (500) further comprises: an imaging unit (501) connected to the image processing unit (600); the endoscopic portion (502) further comprises: an imaging light guide beam and an excitation illumination light guide beam;
the laser light and the white light fused by the optical coupling part (400) irradiate the detection region (503) through the excitation illumination light guide beam, the light reflected or emitted from the detection region (503) enters the imaging part (501) through the imaging light guide beam, and the imaging part (501) sends the image to the image processing part (600) for processing to obtain a color-fluorescence fused image.
8. The endoscopic multispectral excitation imaging system according to claim 1, wherein the at least one laser light source comprises: a first laser source (201), a second laser source (202) and a third laser source (203); wherein,
the first laser source (201) is a laser with a 785 +/-10 nm waveband and is used for exciting indocyanine green and IRDye800CW fluorescent imaging reagents;
the second laser source (202) is a laser with a wave band of 685 +/-10 nm and is used for exciting IRDye680CW fluorescent imaging reagents;
the laser light source III (203) is a laser with a wave band of 390-440nm and is used for autofluorescence imaging;
the white light source part (100) is a white light source with the wave band of 400-650nm, and is used for providing illumination for the detection area (503) and performing visible light imaging.
9. The endoscopic multispectral excitation imaging system according to claim 7, wherein the imaging portion (501) comprises: white light cameras and fluorescence cameras.
10. The endoscopic multispectral excitation imaging system according to claim 2, wherein the control unit (300) is a computer or a single-chip microcomputer.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109945971A (en) * | 2019-04-11 | 2019-06-28 | 福州大学 | Visualization fluorescent optical sensor and preparation method thereof for UV detection |
| CN111974753A (en) * | 2020-08-05 | 2020-11-24 | 中国人民解放军陆军装甲兵学院 | Laser cleaning cleanliness online monitoring device, system and method |
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2016
- 2016-08-31 CN CN201621028445.1U patent/CN206434300U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109945971A (en) * | 2019-04-11 | 2019-06-28 | 福州大学 | Visualization fluorescent optical sensor and preparation method thereof for UV detection |
| CN111974753A (en) * | 2020-08-05 | 2020-11-24 | 中国人民解放军陆军装甲兵学院 | Laser cleaning cleanliness online monitoring device, system and method |
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