CN205795645U - A kind of wide viewing angle optical molecular tomographic navigation system - Google Patents
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Abstract
The utility model discloses a kind of wide viewing angle optical molecular tomographic navigation system, including: system support module (101), for the equipment used in system is provided a supporting role；Synchronize trigger module (201), gather optical imagery and the rotation of filter wheel for synchronizing to trigger CCD camera in optical signalling acquisition module；Optical signalling detecting module (401), the optical signalling in detection imaging region；Data processing module (501), for carrying out parameter setting and processing described optical image data and show to this system.This system and method efficiently solves the method that wide viewing angle optical molecular tomographic airmanship provides navigation for biomedical applications experiment.This system structure is reasonable, practical, can be widely used for research and the research and development of medicine of optical molecular image experiment, has vast potential for future development.
Description
Technical field
This utility model relates to optical molecular image technology field, particularly relates to a kind of wide viewing angle optical molecular tomographic
Navigation system.
Background technology
Molecular image is one of 21 century the most dazzling science and technology, and it refers to detect the most on a molecular scale
Molecule in organism, and provide the Medical Imaging Technology of internal molecular distribution information.And to be proved be that one can be at body
Visualization molecule, gene, the imaging tool of cellular level organism physiological and pathological change.As the molecule shadow that one of which is important
As image mode, optical molecular image relies on self low cost, high flux, non-intruding, noncontact, Non-ionizing radiation, sensitivity
The advantages such as height, high specificity have had been applied to the fields such as the research and development of the early stage detection of tumor, medicine.
Optical molecular image technology, compared to traditional image technology, has a following advantage: one, optical molecular image
The process that gene expression, bio signal transmission etc. are complicated can be become image intuitively by technology, allows one to preferably at molecule
The generation of disease, development mechanism and process is understood in level；They are two years old, it is possible to find molecular variant and the pathological change of disease early stage
Process；Its three, can on live body Continuous Observation medicine or the mechanism of gene therapy and effect.Generally, detection biological tissue molecule
Method chorista detection method and body detection method two kinds, optical molecular image technology as one at body detection method,
It is advantageous that can quickly, at a distance, obtain the image of biological tissue molecule with no damage.It can reveal that the early stage of pathological changes
Molecular biological characteristics, thus the early diagnosis and therapy for disease provides possible, also introduces new concept for clinical diagnosis.
Optical molecular tomographic technology is a kind of optical molecular image technology, and this technology utilizes light in biological tissues
Propagation principle founding mathematical models, and reversely solve, obtain light three-dimension disclocation distributed intelligence in biological tissues, for postgraduate
The physiological and pathological phenomenon of fabric texture provides good technical support.Exciting tomography fluorescence imaging technology is that a kind of optical molecular breaks
Layer imaging technique, its principle can be described as: first to biological internal injection fluorescent molecular probe, fluorescent molecular probe is being given birth to
Object intracellular metabolite can converge at pathological tissues, then by the excitation source of in vitro, irradiates the fluorescence in organism and visits
Pin group so that it is reach higher-energy state, fluorophor absorbs luminous energy and makes electron transition arrive excited state, and electronics is from excited state
Can discharge fluorescence during returning to ground state, this fluorescence relatively exciting light moves to red end, and the wavelength ratio of the fluorescence i.e. launched swashs
The wavelength fluoresced to be grown, and fluorescence is propagated in organizer and some reaches body surface, and the fluorescence sent from body surface is by Gao Ling
The detector of sensitivity receives, thus forms fluoroscopic image.Generally, the fluorescence that fluorophor produces is through organism inner tissue
After absorption, scattering, the when of arriving surface, intensity is the most weak, at this time, it is necessary to utilize highly sensitive CCD camera to capture
Arriving the fluorescent photon on surface, the signal then captured by computer disposal also carries out imaging.Wide viewing angle optical molecular tomography
On the one hand imaging based navigation technology is captured by the fluorescence CCD camera in multispectral optical signalling harvester and sends from organism surface
Fluorescence information, it is thus achieved that fluoroscopic image, recycle white light CCD camera in multispectral optical signalling harvester and capture from biology
The visible ray information that tissue surface sends, it is thus achieved that White-light image, and utilize light optical parametric in biological tissues and propagate former
Reason, reconstructs the 3 D anatomy structure information of imageable target organism, and rebuilds the fluorescent probe of luminescence in birth fabric texture
Particular location and volume size, so, just rebuild except the size of pathological tissues and particular location in biological tissue, raw for analyzing
The physiological and pathological phenomenon of fabric texture provides foundation.
Utility model content
(1) to solve the technical problem that
In view of this, this utility model is according to the feature of optical molecular image technology, and based on long-term at optical molecular shadow
Research experience as technical field, it is provided that a kind of wide viewing angle optical molecular tomographic navigation system and method, uses system
Support the functional modules such as module, synchronization trigger module, optical signalling detecting module and data processing module and realize wide viewing angle light
Learn molecular tomographic and the function of navigation.
(2) technical scheme
According to an aspect of the present utility model, this utility model provides a kind of wide viewing angle optical molecular tomographic and leads
Boat system, this system includes:
System support module 101, for providing a supporting role the equipment used in system；
Synchronize trigger module 201, be used for synchronizing to trigger CCD camera in optical signalling acquisition module and gather optical imagery and filter
The rotation of mating plate rotating disk；
Optical signalling detecting module 401, the optical signalling in detection imaging region；
Data processing module 501, for carrying out parameter setting and processing described optical image data to this system
With display.
(3) beneficial effect
According to above scheme it can be seen that this utility model has the advantages that
1. utilize this utility model, it is possible to use the multispectral signal pickup assembly of multiple stage 601 and light supply apparatus 602, obtain
Multispectral signal in imaging region 301, and utilize the data processing module 501 multispectral signal of the wide viewing angle to collecting to carry out
Three-dimensional reconstruction and display, it is provided that navigation information, efficiently solve wide viewing angle optical molecular tomographic navigation problem.Therefore, it is
Unite multiple functional, and equipment is easy to use.
2. utilize this utility model, can be controlled easily by the software control module 502 in data processing module 501
Optical signalling detecting module 401 and synchronization trigger module 201, make optical signalling detecting module 401 gather multispectral fluorescence data
With white light data.Meanwhile, carried out effectively by the data to collecting of the image processing module 503 in data processing module 501
Process, make the navigation picture after the reconstruction finally given clear and feature highlight.Function is notable, simple and convenient.
3. utilize this utility model, by the convenient design of system support module 101, can the operation such as easy of rise, movement.
Utilize the wide viewing angle multispectral imaging of optical signalling detecting module 401, it is possible to obtain the glimmering of imaging region all angles rapidly
Light image and White-light image information, quickly reconstruct imageable target surface profile information and the information of Internal Fluorescent light source, energy
Enough detect deeper fluorescence information, it is possible to the lowest optical information remained with.
4. by this utility model, owing to needing to carry out lucifuge process in experimentation, meanwhile, by multispectral light
In signal pickup assembly 601 and light supply apparatus 602 place filtering apparatus so that be irradiated to imaging region 301 fluorescence signal and
White light signal has different spectral regions, and meanwhile, multispectral light signal acquisition device 601 also is able to multispectral collect
Signal is successfully separated and comes.Separation due to spectrum so that white light signal and fluorescence signal will not influence each other.Solve reality
In the spectrum mixed questions that faces.
Accompanying drawing explanation
Fig. 1 is the structural representation according to a kind of wide viewing angle optical molecular tomographic navigation system in this utility model
Figure；
Fig. 2 is the structural representation according to the optical signalling detecting module in this utility model；
Fig. 3 is the structural representation according to the system frame module in this utility model.
Detailed description of the invention
For making the purpose of this utility model, technical scheme and advantage clearer, below in conjunction with specific embodiment, and
Referring to the drawings, the utility model is described in further detail.
Fig. 1 is a kind of wide viewing angle optical molecular tomographic navigation system structural representation implemented according to this utility model
Figure, as it is shown in figure 1, this system includes:
System support module (101), for providing a supporting role the equipment used in system；
Synchronize trigger module (201), be used for synchronizing triggering CCD camera in optical signalling acquisition module gather optical imagery and
The rotation of filter wheel；
Optical signalling detecting module (301), the optical signalling in detection imaging region；
Data processing module (501), is arranged and to described optical image data for this system carries out the parameter of necessity
Process and show.
Wherein, as it is shown on figure 3, described system support module (101) includes that system frame (102), data processing module prop up
Frame (103), synchronous triggering device support (104), image display support (105), optical table support (106)；
Wherein: system frame (102), it is used for supporting data processing module support (103), synchronous triggering device support
(104), image display support (105) and optical table support (106), and ensure that system frame self may move, be
System support (102) is longitudinally adjustable, and altitude range overall after regulation is 1 meter～2 meters；Data processing module support (103) is used
In supporting data processing module (501).Synchronous triggering device support (104) is used for supporting synchronization trigger module (202)；Image
Display module support (105) is used for supporting image display (504)；Optical table support (106) is used for supporting optical signalling
Detecting module (401)；Resistance is coupling in system frame (102).
Synchronize trigger module (201) and include synchronous triggering device (202).By synchronous triggering device (202) side, there is one
Signal input interface, is connected with the software control module (502) of data processing module (501) by data wire, receives software control
The input signal of molding block (502)；Meanwhile, its side is other also has signal output interface, is visited with optical signalling by data wire respectively
Survey the fluorescence light source (402) in module (401), white light source (403), fluorescent collecting device (404), white light harvester
(405) it is connected, for defeated to fluorescence light source (402), white light source (403), fluorescent collecting device (404), white light harvester
Go out synchronous triggering signal.
As in figure 2 it is shown, optical signalling detecting module (401) includes that fluorescence light source (402), white light source (403), fluorescence are adopted
Acquisition means (404), white light harvester (405), multiple optical filter (406), optical lens (407).Fluorescence light source (402) is used for
Offer excites fluorescence signal, and the internal front of fluorescence light source is coupled with optical filter (406), and exciting that fluorescence light source (402) provides is glimmering
Optical signal is irradiated to imaging region (301) by after optical filter (406).White light source (403) is used for providing visible light signal, in vain
The internal front of radiant (403) is coupled with optical filter (406), and the visible light signal that white light source (403) provides passes through optical filter
(406) imaging region (301) it is irradiated to after.White light source (403) and fluorescence light source (402) are referred to as light source (602), uniformly divide
Cloth is on optical table support 106.Described light source 602 can carry out wide viewing angle irradiation to imaging region (301).Fluorescent collecting fills
Putting (404) and be used for gathering the fluorescence signal in imaging region (301), the internal front of fluorescent collecting device (404) has optical filter
And optical lens (407) (406).White light harvester (405) is used for gathering the white light signal in imaging region (301), white light
The internal front of harvester (405) has optical filter (406) and optical lens (407).Fluorescent collecting device 404 and white light collection
Device 405 is referred to as multispectral light signal acquisition device (601), and each multispectral light signal acquisition device 601 is evenly distributed on
On optical table support 106.Imaging region (301) can carry out entirely regarding wide viewing angle light signal collection.
Data processing module (501) includes software control module (502), image processing module (503) and image display mould
Block (504).Software control module (502) is responsible for fluorescence light source (402), the white light controlling in optical signalling detecting module (401)
Light source (403), fluorescent collecting device (404), the open and close of white light harvester (405) equipment, parameter are arranged, and control
Make the synchronization of they and Tong Bu trigger module (201) so that fluorescence light source (402), white light source (403), fluorescent collecting device
(404), white light harvester (405) can harmoniously work in order.Software control module makes optical signalling acquisition module
(401) smoothly complete the synchronous data collection of the wide viewing angle of optical signalling in imaging region (301).Image processing module
(503) fluoroscopic image and the White-light image each fluorescent collecting device (404) and white light harvester (405) collected is carried out
Data process, and are largely divided into two aspects, first, fluoroscopic image carry out feature extraction, and feature strengthens and obtains strengthening specific light
The fluoroscopic image of spectrum signal, then carries out Pseudo Col ored Image to the fluoroscopic image strengthened and obtains pseudo-colours fluoroscopic image；And will be white
Light image carries out brightness regulation；Then fluoroscopic image and White-light image sequence are registrated, finally, then by the image after registration
Sequence merges, and forms continuous print fluoroscopic image and the fusion image of White-light image.Secondly, image processing module can enter
Row fluorescence light source three-dimensional reconstruction, is positioned at, according to this system, the imaging area that the multispectral light signal acquisition device of all angles collects
The surface two-dimensional image information of imageable target in territory (301), in conjunction with all angles information of multispectral light signal acquisition device, then
Utilize specific mice surface three dimension structural remodeling algorithm, reconstruct the 3 D anatomy structure information of imageable target.Meanwhile, this reality
Wide viewing angle exciting tomography fluorescence imaging light source can be carried out by the wide viewing angle optical molecular tomographic navigation system of novel proposition
Rebuild.System utilizes all angles that (1) rebuilds the 3 D anatomy structure information of imageable target that obtains, (2) collect many
The mathematical model that spectrum fluoroscopic image and (3) light transmit at organism surface: the diffusion equation (diffusion of light
Equation) model, (4) combine finite element processing method and exciting tomography fluorescence imaging technology, and (5) just can pass through imaging thing
The fluorescence distribution information of surface, reverse derivation goes out out the physical bit in the three dimensional structure information of imageable target Internal Fluorescent light source
Confidence breath and intensity signal, and show in image display (504), utilize reconstructed results to provide interior lights for related personnel
The three-dimensional navigation information in source.Data after image processing module (503) is processed by image display (503) show in real time aobvious
Show on device, navigate for staff.The design of system structure design of the present utility model, especially light source and harvester, and
Specific image sequence processing method ensure that and need not obtain imageable target body by other feature optical imaging device such as CT etc.
Anatomical information, complete the process of three-dimensional fluorescence light source reconstruction.Meanwhile, for carrying out three-dimensional fluorescence light source reconstruction, adopting
The when of collection multispectral data, also need not move the position of imageable target.Ensure that navigation information is efficient, obtain smoothly.
This utility model also proposed a kind of wide viewing angle optical molecular tomographic air navigation aid, comprises the steps:
Step S1: system frame 102 and optical table support 106 are adjusted to suitably by system support module 101
Highly.Open the fluorescent collecting device 404 in optical signalling detecting module 401 and white light harvester 405, open fluorescence simultaneously
Imaging region 301 is irradiated by light source 402 and white light source 403.
Step S2: open the synchronous triggering device 202 in synchronous triggering device 201.Open in data processing module 501
Software control module 502, the synchronization arranging synchronous triggering device 202 in software control module 502 triggers frequency, arranges simultaneously
Fluorescent collecting device 404 and the parameter such as the time of exposure of white light harvester 405, frame speed, arrange fluorescence light source 402 and white light light
The parameters such as the spectral region in source 403, make optical signalling detecting module 401 that imaging region 301 is carried out data acquisition.Open image
Processing module 503, image display 504.
Step S3: trigger frequency according to the synchronization that software control module 502 is arranged, synchronous triggering device 202 synchronizes to trigger
Fluorescence light source 402, white light source 403 carry out the wide viewing angle of predetermined angular and irradiate imaging region 301, synchronize to trigger fluorescence simultaneously
Harvester 402 and white light harvester 405 carry out wide viewing angle data acquisition to imaging region 301.Fluorescence light source 402 and white light
Light source 403 is referred to as light source 602, and they synchronously can carry out 180 degree of wide viewing angles and irradiate imaging region 301, and fluorescence is adopted
Acquisition means 404 and white light harvester 405 are referred to as multispectral light signal acquisition device 601, multicomponent the equipment opened is constituted,
Imaging region can be carried out wide viewing angle data acquisition.
Step S4: the optical signal collected is passed through data line transfer by fluorescent collecting device 404 and white light harvester 405
To data processing module 501, the image processing module 503 in data processing module 501 processes the optical signal data transmitted,
The optical signal transmitted in fluorescent collecting device 404 and white light harvester 405 is carried out by imaging angle and time series
Packet, converts optical signals to digital picture, obtains a series of fluoroscopic image and White-light image, and fluoroscopic image is made feature
Extract, feature strengthens the fluoroscopic image obtaining strengthening special spectrum signal, then carries out the fluoroscopic image strengthened at pseudo-colours
Reason obtains pseudo-colours fluoroscopic image.White-light image is carried out the operation such as brightness adjustment, feature extraction, then by fluoroscopic image with white
Light pattern sequence registrates, and finally, then by the image sequences fusion after registration together, forms continuous print fluoroscopic image with white
The fusion image of light image..
Step S5: it follows that carry out three-dimensional reconstruction, according to the two-dimentional White-light image sequence after processing, and corresponding angle
Information and spectral information, reconstruct the three dimensional structure information on the surface of imageable target body, thus obtain the surface of imageable target body
Structure.And according to fluorescence spectrum and the optical characteristics of white-light spectrum and parameter, reconstruct the optical parametric of the inside of imageable target
Information.Furthermore, the know-why rebuild according to exciting tomography fluorescence imaging, imageable target body is carried out internal illumination fluorescence light source
Three-dimensional reconstruction, reconstruct imageable target internal illumination fluorescence light source physical location in three dimensional structure structural information and fluorescence
Intensity, and show in image display 504, the three-dimensional navigation information of internal light source is provided for related personnel.
Step S6: in data disaply moudle 504, has multiple option, according to the respective option, can show fluoroscopic image,
Display fluoroscopy image sequence (fluorescence video), display White-light image, display White-light image sequence (white light video), display is merged
Figure, display fusion image sequence (fusion image video), the three-dimensional image sequence that the 3-D view of display reconstruction, display are rebuild
(dynamic 3 D image).User of service can be according to the three-dimensional tomographic image data navigation shown in data disaply moudle 504
Information specifically operates.
Particular embodiments described above, has carried out entering one to the purpose of this utility model, technical scheme and beneficial effect
Step describes in detail it should be understood that the foregoing is only specific embodiment of the utility model, is not limited to this reality
With novel, all within spirit of the present utility model and principle, any modification, equivalent substitution and improvement etc. done, all should comprise
Within protection domain of the present utility model.
Claims (5)
1. a wide viewing angle optical molecular tomographic navigation system, it is characterised in that including:
System support module (101), for providing a supporting role the equipment used in system；
Synchronize trigger module (201), be used for synchronizing to trigger CCD camera in optical signalling acquisition module and gather optical imagery and optical filtering
The rotation of sheet rotating disk；
Optical signalling detecting module (401), the optical signalling in detection imaging region；
Described optical signalling detecting module (401) includes fluorescence light source (402), white light source (403), fluorescent collecting device
(404), white light harvester (405), multiple optical filter (406) and multiple optical lens (407)；
Described fluorescence light source (402) is used for providing fluorescence signal, and the internal front of fluorescence light source is coupled with the first optical filter (406),
What fluorescence light source (402) provided excites fluorescence by being irradiated to imaging region (301) after this first optical filter (406)
Described white light source (403) is used for providing visible light signal, and the internal front of white light source (403) is coupled with the second optical filter
(406) visible light signal that, white light source (403) provides is by being irradiated to imaging region after this second optical filter (406)
(301)；
Described white light source (403) and fluorescence light source (402) include multiple, are evenly distributed on optical table support 106, are used for
Imaging region (301) is carried out wide viewing angle irradiation.
A kind of wide viewing angle optical molecular tomographic navigation system the most according to claim 1, it is characterised in that described
System support module (101) includes system frame (102), data processing module support (103), synchronous triggering device support
(104), image display support (105), optical table support (106)；Wherein:
System frame (102), is used for supporting data processing module support (103), synchronous triggering device support (104), image show
Showing module carrier (105) and optical table support (106), described system frame (102) can move, and longitudinally can regulate；
Data processing module support (103) is used for supporting data processing module (501)；Synchronous triggering device support (104) is used for supporting
Synchronize trigger module (202)；The image that image display support (105) is used for supporting in data processing module (501) shows
Module (504)；Optical table support (106) is used for supporting optical signalling detecting module (401).
A kind of wide viewing angle optical molecular tomographic navigation system the most according to claim 2, it is characterised in that:
Described synchronization trigger module (201) includes synchronous triggering device (202)；
Described synchronous triggering device support (104), is used for supporting the synchronous triggering device (202) synchronized in trigger module (201),
Described synchronous triggering device (202) is placed on the front end of synchronous triggering device support (104)；
Described optical detection module (401) is articulated on optical table support (106).
A kind of wide viewing angle optical molecular tomographic navigation system the most according to claim 3, it is characterised in that described same
Step triggers has a signal input interface, by the software control of data wire Yu data processing module (501) by device (202) side
Molding block (502) is connected, and receives the input signal of software control module (502)；Meanwhile, its side is other also has signal output interface,
It is connected with optical signalling detecting module (401) by data wire respectively, synchronizes to trigger to optical signalling detecting module (401) output
Signal.
A kind of wide viewing angle optical molecular tomographic navigation system the most according to claim 1, it is characterised in that fluorescence is adopted
Acquisition means (404) is used for gathering the fluorescence signal in imaging region (301), and the internal front of fluorescent collecting device (404) has the
Two optical filters (406) and the first optical lens (407)；It is white that white light harvester (405) is used for gathering in imaging region (301)
Optical signal, the internal front of white light harvester (405) has the second optical filter (406) and the second optical lens (407)；Fluorescence is adopted
Acquisition means 404 and white light harvester 405 include multiple, are evenly distributed on optical table support 106, for imaging region
(301) carry out entirely regarding wide viewing angle light signal collection.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108187241A (en) * | 2017-12-20 | 2018-06-22 | 西安交通大学医学院第附属医院 | Radiotherapy multi-angle spinning multispectral imaging device |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108187241A (en) * | 2017-12-20 | 2018-06-22 | 西安交通大学医学院第附属医院 | Radiotherapy multi-angle spinning multispectral imaging device |
| CN108187241B (en) * | 2017-12-20 | 2019-12-17 | 西安交通大学医学院第一附属医院 | multi-angle self-rotating multispectral imaging device for radiotherapy |
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